Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60.

J Biol Chem. 1997 Dec 5;272(49):30595-8. Unique Identifier : AIDSLINE MED/98049511
Yamamoto T; Horikoshi M; Laboratory of Developmental Biology, Department of Cellular Biology,; Institute of Molecular and Cellular Biosciences, The University of; Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113, Japan.

Abstract: Tip60, originally isolated as an HIV-1-Tat interactive protein, contains an evolutionarily conserved domain with yeast silencing factors. We demonstrate here direct biochemical evidence that this domain of Tip60 has histone acetyltransferase activity. The purified recombinant effectively acetylates H2A, H3, and H4 but not H2B of core histone mixtures. This substrate specificity has not been observed among histone acetyltransferases analyzed to date. These results indicate that Tip60 is a histone acetyltransferase with a novel property, suggesting that Tip60 and its related factors may introduce a distinct alteration on chromatin.
Keywords: *Acetyltransferases/METABOLISM *Proteins/METABOLISMKWDacetyltransferases/metabolismKWDproteins/metabolism
980330
M9830979

Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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