1998

Organizational factors related to AIDS/HIV education in outpatient substance abuse treatment units.: J Health Soc Policy. 1998;9(3):1-13. Unique Identifier : AIDSLINE MED/98063622; Clapp JD; School of Social Work, University of Nevada, Las Vegas 89154, USA.; The association of HIV and AIDS with intravenous drug use is well documented. Given this, substance abuse treatment providers must figure prominently in any effective national response to HIV/AIDS. The strategies employed by human service managers to address AIDS may be important in explaining how substance abuse trea
The media and AIDS: health elite perspectives of coverage.: J Health Soc Policy. 1998;9(3):45-69. Unique Identifier : AIDSLINE MED/98063625; Backstrom CH; Robins LS; Department of Political Science, University of Minnesota, USA.; Most writers assessing AIDS have been critical of the media s coverage of this epidemic. To ascertain the views of key elites on media coverage of AIDS, the authors surveyed chief state public health officers, chairs of legislative health committees, and directors of hospital associations. In general, these groups ten
The odds grow longer. Doctors had hoped by now to have eliminated the AIDS virus from some patients. No such luck.: Time. 1997 Nov 24;150(22):84. Unique Identifier : AIDSLINE MED/98077150; Gorman C
AIDS drugs fail a test. New studies show they don't eliminate all HIV.: Newsweek. 1997 Nov 24;130(21):61. Unique Identifier : AIDSLINE MED/98077123; Cowley G
AIDS comes to small-town America.: US News World Rep. 1997 Nov 10;123(18):52-5. Unique Identifier : AIDSLINE MED/98063565; Brownlee S; McDonald M; Ackerman E
A typological approach to the study of rural HIV service delivery networks [see comments]: J Rural Health. 1997 Summer;13(3):216-25. Unique Identifier : AIDSLINE MED/98072136; Berry DE; McKinney MM; Marconi KM; Community Health Solutions Inc., Richmond, KY 40475, USA.; Despite the rapid growth of AIDS cases in nonmetropolitan areas, little is known about the characteristics and needs of HIV-positive rural residents or how rural areas are responding to the epidemic. This paper proposes a typology for distinguishing among rural environments and examining variations in HIV service netw
Delivering care to rural HIV/AIDS patients [see comments]: J Rural Health. 1997 Summer;13(3):226-36. Unique Identifier : AIDSLINE MED/98072137; Topping S; Hartwig LC; Cecil G. Sheps Center for Health Services Research, Chapel Hill, NC; 27599, USA.; With HIV/AIDS on the rise in rural areas, health care providers must find ways of delivering care with little or no increase in resource support. This paper examines the evolution of a rural HIV/AIDS alliance using a life cycle model to identify each stage of the alliance development and the specific issues associated
AIDS in rural America [comment]: J Rural Health. 1997 Summer;13(3):237-9. Unique Identifier : AIDSLINE MED/98072138; Cohn SE; University of Rochester Medical Center, NY 14642, USA.
HIV and blood transfusion in sub-Saharan Africa.: Transfus Sci. 1997 Jun;18(2):167-79. Unique Identifier : AIDSLINE MED/98052799; Fleming AF; University Teaching Hospital, Lusaka, Zambia.; Blood transfusion services were poorly developed until the mid 1980s in most of sub-Saharan Africa, and were unable to provide adequate supplies of blood with acceptable safety. The pandemic of HIV was recognized seroepidemiologically from 1985 onwards. Blood transfusion was contributing from 10 to 15% to transmission
Gene therapy for AIDS.: Transfus Sci. 1997 Jun;18(2):277-89. Unique Identifier : AIDSLINE MED/98052812; Sorg T; Methali M; Department of Gene Therapy, Transgene, Strasbourg, France.; The absence of effective treatments makes AIDS one obvious candidate among the infectious diseases which might be treated by somatic gene therapy. Since HIV1 predominantly infects cells of the haematopoietic system, multipotent stem cells or more mature CD4+ cells constitute potential targets for the introduction of a
Therapeutic options for HIV-associated bodyweight loss. A risk-benefit analysis.: Drug Saf. 1997 Nov;17(5):290-302. Unique Identifier : AIDSLINE MED/98053261; Stosor V; Roenn JV; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois, USA.; Involuntary bodyweight loss, a common complication of infection with HIV, is an indicator of poor prognosis and decreased survival. Because of the multifactorial pathogenesis of HIV-related wasting, emerging therapies are directed at the multiple proposed mechanisms of involuntary bodyweight loss. The initial evaluati
Abdominal CT features and survival in acquired immunodeficiency.: Acta Radiol. 1997 Nov;38(6):970-7. Unique Identifier : AIDSLINE MED/98056633; Knollmann FD; Maurer J; Grunewald T; Schedel H; Vogl TJ; Pohle HD; Felix R; Department of Radiology, Virchow Hospital, Faculty of Medicine,; Humboldt University of Berlin, Germany.; PURPOSE: HIV-infected patients show a high incidence of abdominal disease. This investigation was made to determine whether abdominal CT provided prognostically relevant information in these patients. MATERIAL AND METHODS: Images from 533 abdominal CT examinations in 339 HIV-infected patients were retrospectively revi
Role of viral infection in porphyria cutanea tarda.: Photodermatol Photoimmunol Photomed. 1997 Jun;13(3):75-7. Unique Identifier : AIDSLINE MED/98039787; Lim HW; Department of Dermatology, Henry Ford Hospital, Detroit, MI; 48202-2689, USA.; HIV infection is associated with abnormal porphyrin metabolism. While HCV infection alone is thus far not associated with significant abnormal porphyrin levels, it does contribute to further elevation of porphyrin levels in patients already infected with HIV. These infections alone are not sufficient to induce the dev
UVB and PUVA therapies in HIV patients: are they safe?: Photodermatol Photoimmunol Photomed. 1997 Jun;13(3):91-2. Unique Identifier : AIDSLINE MED/98039793; Beer JZ; Zmudzka BZ; Food and Drug Administration, Rockville, Maryland 20857, USA.
Intracellular immunization of rhesus CD34+ hematopoietic progenitor cells with a hairpin ribozyme protects T cells and macrophages from simian immunodeficiency virus infection.: Blood. 1997 Dec 15;90(12):4822-31. Unique Identifier : AIDSLINE MED/98052537; Rosenzweig M; Marks DF; Hempel D; Heusch M; Kraus G; Wong-Staal F; Johnson RP; New England Regional Primate Research Center, Harvard Medical School,; Southborough, MA 01772, USA.; Evaluation of candidate genes for stem cell gene therapy for acquired immunodeficiency syndrome (AIDS) has been limited by the difficulty of supporting in vitro T-cell differentiation of genetically modified hematopoietic progenitor cells. Using a novel thymic stromal culture technique, we evaluated the ability of a h
Robust, but transient expression of adeno-associated virus-transduced genes during human T lymphopoiesis.: Blood. 1997 Dec 15;90(12):4854-64. Unique Identifier : AIDSLINE MED/98052540; Gardner JP; Zhu H; Colosi PC; Kurtzman GJ; Scadden DT; Division of Experimental Hematology, AIDS Research Center, MGH Cancer; Center, Massachusetts General Hospital, Harvard Medical School,; Boston, MA 02129, USA.; Recombinant adeno-associated viruses (rAAV) have been proposed to be gene transfer vehicles for hematopoietic stem cells with advantages over other virus-based systems due to their high titers and relative lack of dependence on cell cycle for target cell integration. We evaluated rAAV vector containing a LacZ reporter
Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen.: Blood. 1997 Dec 15;90(12):4894-900. Unique Identifier : AIDSLINE MED/98052544; Gaidano G; Gloghini A; Gattei V; Rossi MF; Cilia AM; Godeas C; Degan M; Perin T; Canzonieri V; Aldinucci D; Saglio G; Carbone A; Pinto A; Division of Internal Medicine, Department of Medical Sciences,; University of Torino at Novara, Novara, Italy.; Primary effusion lymphoma (PEL) represents a novel B-cell non-Hodgkin s lymphoma (NHL) type associated with Kaposi s sarcoma-associated herpesvirus infection and typically growing as lymphomatous effusions in the body cavities. The precise B-cell subset from which PEL originates as
Repression of transcription from the human T-cell leukemia virus type I long terminal repeat and cellular gene promoters by wild-type p53.: Blood. 1997 Dec 15;90(12):4924-32. Unique Identifier : AIDSLINE MED/98052548; Mori N; Kashanchi F; Prager D; Division of Hematology/Oncology, University of California at Los; Angeles School of Medicine, Los Angeles, CA, USA.; Human T-cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells both in vivo and in vitro. However, the long latency period between infection and development of ATL, as well as the small fraction of the infected population that actually develops this disease, su
Idiopathic CD4+ T-lymphocytopenia [editorial; comment]: Intern Med. 1997 Nov;36(11):759. Unique Identifier : AIDSLINE MED/98052237; Torikai K
Idiopathic CD4+ T-lymphocytopenia with Bowen's disease [see comments]: Intern Med. 1997 Nov;36(11):822-4. Unique Identifier : AIDSLINE MED/98052251; Hayashi T; Hinoda Y; Takahashi T; Adachi M; Miura S; Izumi T; Kojima H; Yano S; Imai K; First Department of Internal Medicine, Sapporo Medical University; School of Medicine.; A 39-year-old man with Bowen s disease was troubled with multiple molluscum contagiosum over the trunk and lower extremities. Subsequently oral candidiasis was complicated. Laboratory examination revealed lymphocytopenia and a decrease in the CD4/CD8 ratio. His CD4+ T-lymphocyte count was only 187 cells/microl one tim
[Serological diagnosis in HIV infection]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jul-Sep;42(3):125-30. Unique Identifier : AIDSLINE MED/98030155; Negut EA; Usein CR; Institutul Cantacuzino.
[The pathogenesis of viral hepatitis C]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jul-Sep;42(3):167-72. Unique Identifier : AIDSLINE MED/98030164; Tecu C; Institutul Cantacuzino.
Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: prospective multicentre study. Swiss HIV Cohort Study.: BMJ. 1997 Nov 8;315(7117):1194-9. Unique Identifier : AIDSLINE MED/98054931; Egger M; Hirschel B; Francioli P; Sudre P; Wirz M; Flepp M; Rickenbach M; Malinverni R; Vernazza P; Battegay M; Department of Social and Preventive Medicine, University of Berne,; Switzerland.; OBJECTIVES: To examine trends in disease progression and survival among patients enrolled in the Swiss HIV cohort study during 1988-96 and to assess the influence of new antiretroviral combination therapies. DESIGN: Prospective multicentre study, with follow up visits planned at six monthly intervals. SETTING: Seven H
Is the clinical course of HIV infection changing? Finding is disheartening [letter]: BMJ. 1997 Nov 8;315(7117):1236. Unique Identifier : AIDSLINE MED/98054956; Porter K
Is the clinical course of HIV infection changing? Exclusion of people not followed up for 12 months may have biased results [letter]: BMJ. 1997 Nov 8;315(7117):1236-7. Unique Identifier : AIDSLINE MED/98054957; Law MG; Kaldor JM
Is the clinical course of HIV infection changing? Study's censoring strategy may be source of bias [letter]: BMJ. 1997 Nov 8;315(7117):1237. Unique Identifier : AIDSLINE MED/98054958; Cozzi Lepri A; Phillips AN; Pezzotti P; Rezza G
Sexually transmitted diseases among teenagers in England and Wales.: Commun Dis Rep CDR Rev. 1997 Nov 14;7(12):R173-8. Unique Identifier : AIDSLINE MED/98055854; Connor N; Catchpole M; Rogers PA; Macdonald N; Mc Garrigle C; Simms I; Radcliffe L; Gilbart V; Clarke SE; Webster J; Nicoll A; PHLS AIDS and STD Centre, PHLS Communicable Disease Surveillance; Centre, London. anicoll@phls.co.uk; A profile of sexually transmitted diseases (STDs) and HIV infections among teenagers in England and Wales was obtained from reports of newly diagnosed STDs among teenagers attending genitourinary medicine (GUM) clinics in 1995, laboratory reports of newly diagnosed HIV infections between 1985 when reporting began and
CD4 cell counts of 200 x 10(6)/1 or below in natural history studies and surveillance: is one enough or are two better?: Commun Dis Rep CDR Rev. 1997 Nov 14;7(12):R179-85. Unique Identifier : AIDSLINE MED/98055855; Easterbrook PJ; Yu LM; McLean K; Hawkins D; Gazzard B; HIV Epidemiology Unit, Department of HIV/Genitourinary Medicine,; Charing Cross Hospital.; A retrospective cohort study was performed to examine the extent and clinical significance of misclassification associated with using the current United States AIDS case defining category of an initial CD4 count
[Study by the Professional Organization of German Transfusion Physicians on epidemiology of HIV- and hepatitis infections in blood donors]: Beitr Infusionsther Transfusionsmed. 1997;34:1-4. Unique Identifier : AIDSLINE MED/98019468; Gluck D; Maurer C; Kubanek B; Studiensekretariat des Berufsverbands Deutscher Transfusionsmediziner; e. V., Ulm, Deutschland.; The frequency of the seromarkers of HIV, HCV, and HBV in the donor population from all donor centers in Germany became available from the multicenter study of the transfusion services. From these data the risk of virus transmission by blood products can be estimated at 1:1 million
[Routine PCR screening for HBV, HCV and HIV-I genome in a large blood donation services--experiences and initial results]: Beitr Infusionsther Transfusionsmed. 1997;34:21-5. Unique Identifier : AIDSLINE MED/98019472; Schottstedt V; Tuma W; Bunger G; Lakenberg P; DRK-Blutspendedienst Nordrhein-Westfalen, Institut Hagen, Deutschland.; We adapted the PCR method to screen up to 3,000 blood donations per day for HBV, HCV, and HIV-1 contamination. Concerning logistics: The first step is the generation of 3 identical microtiter plates (PT) by using the self-validated automatic sample processor with disposable tips. Using the first PT, we pooled up to 60
[Plasma donor screening and product safety]: Beitr Infusionsther Transfusionsmed. 1997;34:31-6. Unique Identifier : AIDSLINE MED/98019474; Storch H; Ponsel G; Igel H; Worofka R; IMMUNO GmbH Heidelberg.; In addition to the specific virus reduction and inactivation procedures during the manufacturing process, the thorough selection of the source material is an essential factor for the product safety of plasmaderivatives. Screening of donors, inventory hold, and plasma pool testing by PCR are important aspects in raisin
Efficient gene transfer into primary and immortalized human fetal glial cells using adeno-associated virus vectors: establishment of a glial cell line with a functional CD4 receptor.: J Neurovirol. 1997 Oct;3(5):322-30. Unique Identifier : AIDSLINE MED/98039722; Keir SD; Miller J; Yu G; Hamilton R; Samulski RJ; Xiao X; Tornatore C; Laboratory of Molecular Medicine and Neuroscience, National Institute; of Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, Maryland 20892, USA.; Adeno associated virus (AAV) is a non-pathogenic dependent parvovirus with a broad host range, capable of high levels of transduction and stable integration into the host cell genome. We have investigated the potential for using AAV as a vector for gene transfer into glial cells of the human fetal nervous system. Reco
HIV-1 LTR DNA sequence variation in brain-derived isolates.: J Neurovirol. 1997 Oct;3(5):331-41. Unique Identifier : AIDSLINE MED/98039723; Corboy JR; Garl PJ; University of Colorado Health Sciences Center, Department of; Neurology, Denver 80262, USA.; Isolates of human immunodeficiency virus (HIV-1) derived from the central nervous system (CNS) display properties distinctive from blood-derived isolates, including a high incidence of macrophage tropism in CNS isolates. Macrophage tropism is a result, in part, of DNA sequence variation in the HIV-1 envelope glycoprot
Regulation of glutathione and cell toxicity following exposure to neurotropic substances and human immunodeficiency virus-1 in vitro.: J Neurovirol. 1997 Oct;3(5):342-9. Unique Identifier : AIDSLINE MED/98039724; Koutsilieri E; Gotz ME; Sopper S; Sauer U; Demuth M; ter Meulen V; Riederer P; Department of Psychiatry, Clinical Neurochemistry, Julius Maximilians; University, Wurzburg, Germany.; The aim of the present study was to assess the toxic potential of drugs of abuse and other neuropharmacological agents in the pathogenesis of AIDS dementia complex (ADC), the neurological complication of AIDS. Neuroblastoma and glioblastoma cell lines expressing the dopamine transp
Semliki Forest virus infection leads to increased expression of adhesion molecules on splenic T-cells and on brain vascular endothelium.: J Neurovirol. 1997 Oct;3(5):350-60. Unique Identifier : AIDSLINE MED/98039725; Soilu-Hanninen M; Roytta M; Salmi AA; Salonen R; Turku Immunology Centre, University of Turku, Finland.; Semliki Forest virus A7 (SFV-A7) is a neurotropic alphavirus that leads to an asymptomatic encephalitis in adult immunocompetent mice. We studied the expression of leukocyte and endothelial cell adhesion molecules in the spleen and in the central nervous system (CNS) during SFV-A7 infection. Kinetics of the expression
Neuropathology in cats experimentally infected with feline immunodeficiency virus: a morphological, immunocytochemical and morphometric study.: J Neurovirol. 1997 Oct;3(5):361-8. Unique Identifier : AIDSLINE MED/98039726; Poli A; Abramo F; Di Iorio C; Cantile C; Carli MA; Pollera C; Vago L; Tosoni A; Costanzi G; Department of Animal Pathology, University of Pisa, Italy.; Neuropathological changes have been described associated with feline immunodeficiency virus (FIV) infection. The objective of our study was to characterize the lesions found in the brain and spinal cord of experimentally FIV-infected cats and to quantify, by morphometric analysis, the intensity of gliosis found in the
HIV-related interstitial lung disease.: Curr Opin Pulm Med. 1995 Sep;1(5):383-91. Unique Identifier : AIDSLINE MED/98029387; Semenzato G; Agostini C; Padua University School of Medicine, Italy.; The progressive breakdown of the cell-mediated immunity, which characterizes the natural history of HIV infection, invariably leads to the development of miscellaneous opportunistic infections or neoplasms involving a number of tissues, including the respiratory tract. In particular, given the extent and the severity
Methodological considerations in estimating speed of cognitive operations.: J Int Neuropsychol Soc. 1995 Jan;1(1):3-9. Unique Identifier : AIDSLINE MED/98042772; Becker JT; Caldararo R; Baddeley AD; Dew MA; Heindel WC; Banks G; Dorst SK; Lopez OL; Department of Psychiatry, University of Pittsburgh Medical Center, PA; 15213, USA.; Individuals infected with Human Immunodeficiency Virus (HIV) and having cognitive impairment have been described as having slow mentation. Data supporting this proposition come from a variety of sources, including Sternberg s (1966) item recognition memory task. The procedure nominally provides an index of speed of me
The HNRC 500--neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center.: J Int Neuropsychol Soc. 1995 May;1(3):231-51. Unique Identifier : AIDSLINE MED/98042788; Heaton RK; Grant I; Butters N; White DA; Kirson D; Atkinson JH; McCutchan JA; Taylor MJ; Kelly MD; Ellis RJ; et al; University of California at San Diego, Dept. of Psychiatry, La Jolla,; 92093, USA.; The present study examined neuropsychological (NP) functioning and associated medical, neurological, brain magnetic resonance imaging (MRI), and psychiatric findings in 389 nondemented males infected with Human Immunodeficiency Virus-Type 1 (HIV-1), and in 111 uninfected controls. Using a comprehensive NP test battery
Neuropsychological studies of asymptomatic human immunodeficiency virus-type-1 infected individuals. The HNRC Group. HIV Neurobehavioral Research Center.: J Int Neuropsychol Soc. 1995 May;1(3):304-15. Unique Identifier : AIDSLINE MED/98042795; White DA; Heaton RK; Monsch AU; Department of Psychiatry, University of California, San Diego, La; Jolla 92093, USA.; The current review was conducted to address the ongoing debate regarding the presence or absence of neuropsychological impairment in asymptomatic HIV-Type 1 (HIV-1) seropositive individuals. Results were summarized from 57 studies that compared the performances of seropositive asymptomatic and seronegative individuals
Delayed recognition memory span in HIV-1 infection.: J Int Neuropsychol Soc. 1995 Nov;1(6):575-80. Unique Identifier : AIDSLINE MED/98042815; Martin EM; Pitrak DL; Pursell KJ; Mullane KM; Novak RM; Department of Psychiatry, University of Illinois-Chicago 60612, USA.; eileen.m.martin@uic.edu; We administered a spatial version of the Delayed Recognition Span Test (DRST), a working memory task performed abnormally by patients with basal ganglia disease, to a group of 96 HIV-seropositive and 83 seronegative subjects with a high prevalence of substance abuse. For comparison purposes, we also administered the S
Relationship between psychiatric disease and neuropsychological impairment in HIV seropositive individuals.: J Int Neuropsychol Soc. 1995 Nov;1(6):581-8. Unique Identifier : AIDSLINE MED/98042816; Bix BC; Glosser G; Holmes W; Ballas C; Meritz M; Hutelmyer C; Turner J; Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania; 19146, USA.; Neuropsychological impairment and DSM-III-R Axis I psychiatric diagnoses were evaluated in a heterogenous group of HIV seropositive individuals and seronegative individuals with similar risk factors for HIV infection. Neuropsychological and psychiatric disorders were common in the HIV seropositive group, but there wer
Neuropsychological deficits in HIV-1 seropositive and seronegative intravenous drug users (IVDUs): a follow-up study.: J Int Neuropsychol Soc. 1996 Mar;2(2):126-33. Unique Identifier : AIDSLINE MED/98042766; Hestad K; Aukrust P; Ellertsen B; Klove H; Department of Biological and Medical Psychology, University of Bergen,; Norway.; Human immunodeficiency virus type 1 (HIV-1) seropositive AIDS free and HIV-1 seronegative intravenous drug users were tested twice with a comprehensive neuropsychological test battery. Only minor group differences were found. Memory difficulties were the most pronounced difference with lower scores in the HIV-1 seropo
Subjective complaints of cognitive symptoms are related to psychometric findings of memory deficits in patients with HIV-1 infection.: J Int Neuropsychol Soc. 1996 May;2(3):219-25. Unique Identifier : AIDSLINE MED/98042756; Poutiainen E; Elovaara I; Department of Neurology, University of Helsinki, Finland.; Eighty-five subjects at various stages of human immunodeficiency virus (HIV-1) infection and 39 seronegative controls underwent neurological and neuropsychological evaluation to assess the relationship between cognitive test results and subjective complaints (cognitive, affective, motor, and other). The effect of psyc
Comparison of hydroxychloroquine with zidovudine in asymptomatic patients infected with human immunodeficiency virus type 1.: Clin Ther. 1997 Sep-Oct;19(5):913-23. Unique Identifier : AIDSLINE MED/98046590; Sperber K; Chiang G; Chen H; Ross W; Chusid E; Gonchar M; Chow R; Liriano O; Division of Clinical Immunology, Mount Sinai Medical Center, New York,; New York, USA.; Hydroxychloroquine (HCQ), an antimalarial agent used to treat patients with autoimmune diseases, has been shown to suppress human immunodeficiency virus type 1 (HIV-1) replication in T cells and monocytes in vitro by inhibiting posttranscriptional modification of the virus. An initial randomized, placebo-controlled cl
Sendai virus-based expression of HIV-1 gp120: reinforcement by the V(-) version.: Genes Cells. 1997 Jul;2(7):457-66. Unique Identifier : AIDSLINE MED/98031879; Yu D; Shioda T; Kato A; Hasan MK; Sakai Y; Nagai Y; Department of Viral Infection, Institute of Medical Science,; University of Tokyo, Japan.; BACKGROUND: We have established a system for recovering Sendai virus (SeV), a nonsegmented negative strand RNA virus, entirely from cDNA at an extremely high rate, and have succeeded in creating a V(-) SeV whose gene expression was greatly enhanced by the deletion of the nonessential V gene. Because of its extreme med
Stigmatization, discrimination and fear of AIDS in Greece: implications for health policy.: Ethn Health. 1996 Dec;1(4):359-71. Unique Identifier : AIDSLINE MED/98051762; Chliaoutakis J; Trakas DJ; Department of Health Visiting, Technological Educational Institution; of Athens, Greece.; A prospective health-education research project about AIDS knowledge and attitudes towards AIDS was conducted in Athens and nine adjacent municipalities in west Attica, Greece . Socioeconomic and demographic data, AIDS knowledge, and
Differential survival in blacks and Hispanics with AIDS.: Ethn Health. 1996 Dec;1(4):373-82. Unique Identifier : AIDSLINE MED/98051763; Murrain M; School of Natural Science, Hampshire College, Amhurst, MA 01002, USA.; OBJECTIVE: The object of this study was to investigate whether there are differences in survival by ethnicity in people with AIDS. DESIGN: The CDC Public Access Dataset was analysed. To estimate survival more accurately, a cohort of individuals diagnosed in 1987 was chosen from the dataset. Using this analysis, probab
Evaluating the role of Th0 and Th1 clones in autoimmune thyroid disease by use of Hu-SCID chimeras.: Clin Immunol Immunopathol. 1997 Dec;85(3):253-64. Unique Identifier : AIDSLINE MED/98063345; Fisfalen ME; Soltani K; Kaplan E; Palmer EM; van Seventer GA; Straus FH; Diaz M; Ober C; DeGroot LJ; Department of Medicine, University of Chicago, Illinois 60637, USA.; To study the role of Th0 and Th1 cells in autoimmune thyroid disease, thyroid tissues from patients with Graves disease (GD), Hashimoto s thyroiditis (HT), and colloid nodular disease were xenografted into SCID mice, followed by ip injection of peripheral blood mononuclear cells (PBMC), T cell lines, and T cell clone
Lymphocyte phenotyping in infants: maturation of lymphocyte subpopulations and the effects of HIV infection.: Clin Immunol Immunopathol. 1997 Dec;85(3):273-81. Unique Identifier : AIDSLINE MED/98063347; Rich KC; Brambilla D; Pitt J; Moye J; Cooper E; Hillyer G; Mendez H; Fowler MG; Landay A; University of Illinois at Chicago, Illinois 60612, USA.; Changes in the distribution of lymphocyte subpopulations in infants with perinatally acquired HIV infection are confounded by the rapid changes that are the result of normal maturation of the immune system. We describe the changes in seven lymphocyte phenotypes (CD3+ CD4+, CD3+ CD8+, CD8+ HLA- DR+, CD8+ CD38+, CD8+ CD
Role of T-cell subsets in acute and persistent E-55+ murine leukemia virus infection in susceptible progressor and resistant long-term nonprogressor mouse strains. Women and Infants Transmission Study.: Clin Immunol Immunopathol. 1997 Dec;85(3):282-8. Unique Identifier : AIDSLINE MED/98063348; Avidan N; Sieck TG; Blank KJ; Department of Pathology and Laboratory Medicine, Allegheney University; of the Health Sciences, Philadelphia, Pennsylvania 19102, USA.; Previous studies from this laboratory have demonstrated that E-55+MuLV-infected BALB/c-H-2k (BALB.K) mice progress to develop thymic lymphoma about 7 months after infection whereas infected C57BL/10-H-2k (B10.BR) mice are long-term nonprogressors that fail to develop disease even after 2 years of infection. Both resis
Patterns of in vitro anti-human immunodeficiency virus type 1 antibody production in long-term nonprogressors.: Clin Immunol Immunopathol. 1997 Dec;85(3):320-3. Unique Identifier : AIDSLINE MED/98063352; Rusconi S; Berlusconi A; Papagno L; Colombo MC; De Maddalena C; Riva A; Bagnarelli P; Balotta C; Galli M; Istituto di Malattie Infettive, Universita di Milano, Ospedale Luigi; Sacco, Italy. rusconi@imiucca.csi.unimi.it; With the aim of evaluating the specific pattern of in vitro antibody production (IVAP) in human immunodeficiency virus type 1 HIV-1)-infected long-term non-progressors (LTNPs), we tested 20 subjects who had remained asymptomatic for more than 8 years with a CD4+ cell count higher than 500/microliter and 59 patients at
Expression of a newly identified phosphate transporter/retrovirus receptor in human SaOS-2 osteoblast-like cells and its regulation by insulin-like growth factor I.: Endocrinology. 1997 Dec;138(12):5202-9. Unique Identifier : AIDSLINE MED/98049370; Palmer G; Bonjour JP; Caverzasio J; Department of Medicine, University of Geneva, Switzerland.; The cell surface receptor for gibbon ape leukemia virus (Glvr-1) was recently demonstrated to serve normal cellular functions as a sodium-dependent phosphate (NaPi) transporter. This protein belongs to a newly identified phosphate transporter/retrovirus receptor gene family distinct from renal type I and II NaPi trans
Changes in 1,25-(OH)2D3 synthesis and its receptor expression in spleen cell subpopulations of mice infected with LPBM5 retrovirus.: Endocrinology. 1997 Dec;138(12):5505-10. Unique Identifier : AIDSLINE MED/98049405; Nguyen TM; Pavlovitch J; Papiernik M; Guillozo H; Walrant-Debray O; Pontoux C; Garabedian M; CNRS, URA 583, Universite Paris V, Hopital Saint-Vincent de Paul,; France.; This study examines the influence of chronic retroviral infection of mice with a LPBM5 virus mixture on the paracrine system involving immune cells and 1,25-(OH)2D3 in the spleen. Plasma ionized calcium, 25-(OH)D and 1,25-(OH)2D of infected mice were unchanged. In contrast, the specific binding of 1,25-(OH)2D3 to sple
[The clinical concept of spondyloarthropathies]: Fortschr Med. 1997 Sep 20;115(26):44-5. Unique Identifier : AIDSLINE MED/98011133; Braun J; Sieper J
Non-Hodgkin's lymphoma among people with AIDS: incidence, presentation and public health burden. AIDS/Cancer Study Group.: Int J Cancer. 1997 Nov 27;73(5):645-50. Unique Identifier : AIDSLINE MED/98058682; Cote TR; Biggar RJ; Rosenberg PS; Devesa SS; Percy C; Yellin FJ; Lemp G; Hardy C; Geodert JJ; Blattner WA; Viral Epidemiology Branch, Division of Cancer Etiology, National; Cancer Institute, Rockville, MD, USA.; We describe the anatomic and histologic presentation and prognosis of non-Hodgkin s lymphoma (NHL) among people with AIDS PWA) and determine their contribution to the NHL burden. We linked AIDS and cancer registries in selected areas of the United State
Adolescents with psychiatric disorders and the risk of HIV.: J Am Acad Child Adolesc Psychiatry. 1997 Nov;36(11):1609-17. Unique Identifier : AIDSLINE MED/98056957; Brown LK; Danovsky MB; Lourie KJ; DiClemente RJ; Ponton LE; Department of Child and Family Psychiatry, Rhode Island Hospital,; Providence 02903, USA.; OBJECTIVE: To review literature relevant to human immunodeficiency virus (HIV)-associated risk behaviors among adolescents with psychiatric disorders and psychological influences on risk behaviors. METHOD: This report is based on review of 66 articles, which comprise all of the relevant literature in the English langu
The infection control practices of general dental practitioners.: Infect Control Hosp Epidemiol. 1997 Oct;18(10):699-703. Unique Identifier : AIDSLINE MED/98011549; McCarthy GM; MacDonald JK; School of Dentistry, Faculty of Medicine and Dentistry, University of; Western Ontario, London, Canada.; OBJECTIVES: To investigate the infection control practices of general dentists in Ontario in 1994. DESIGN: Confidential coded questionnaires were mailed to all general dental practitioners in Ontario (n = 5,176), with three follow-up attempts. Data were analyzed using Pearson s chi-squared test and multiple logistic r
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas [see comments]: J Exp Med. 1997 Dec 1;186(11):1819-29. Unique Identifier : AIDSLINE MED/98044247; Sousa CR; Hieny S; Scharton-Kersten T; Jankovic D; Charest H; Germain RN; Sher A; Lymphocyte Biology Section, Laboratory of Immunology, National; Institute of Allergy and Infectious Diseases, National Institutes of; Health, Bethesda, Maryland 20892-1892, USA. caetano@nih.gov; The early induction of interleukin (IL)-12 is a critical event in determining the development of both innate resistance and adaptive immunity to many intracellular pathogens. Previous in vitro studies have suggested that the macrophage (MPhi) is a major source of the initial IL-12 produced upon microbial stimulation a
Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV CD26)-mediated cleavage.: J Exp Med. 1997 Dec 1;186(11):1865-72. Unique Identifier : AIDSLINE MED/98044251; Oravecz T; Pall M; Roderiquez G; Gorrell MD; Ditto M; Nguyen NY; Boykins R; Unsworth E; Norcross MA; Division of Hematologic Products, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.; tamas@helix.nih.gov; CD26 is a leukocyte activation marker that possesses dipeptidyl peptidase IV activity but whose natural substrates and immunological functions have not been clearly defined. Several chemo-kines, including RANTES (regulated on activation, normal T cell expressed and secreted), have now been shown to be substrates for r
Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses.: J Virol. 1997 Dec;71(12):8999-9007. Unique Identifier : AIDSLINE MED/98037607; Rucker J; Edinger AL; Sharron M; Samson M; Lee B; Berson JF; Yi Y; Margulies B; Collman RG; Doranz BJ; Parmentier M; Doms RW; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; Human immunodeficiency virus type 1 (HIV-1) requires both CD4 and a coreceptor to infect cells. Macrophage-tropic (M-tropic) HIV-1 strains utilize the chemokine receptor CCR5 in conjunction with CD4 to infect cells, while T-cell-tropic (T-tropic) strains generally utilize CXCR4 as a coreceptor. Some viruses can use bo
The roles of the human immunodeficiency virus type 1 Pol protein and the primer binding site in the placement of primer tRNA(3Lys) onto viral genomic RNA.: J Virol. 1997 Dec;71(12):9075-86. Unique Identifier : AIDSLINE MED/98037615; Liang C; Rong L; Morin N; Cherry E; Huang Y; Kleiman L; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute-Jewish General; Hospital, Montreal, Quebec, Canada.; Factors that modulate the placement of primer tRNA(3Lys) onto the viral RNA genome in human immunodeficiency virus type 1 (HIV-1) were investigated through analysis of reverse-transcribed products that are extended from the tRNA(3Lys) primer. Mutations were introduced into the HIV-1 pol gene to result in the appearanc
Astrocyte-specific expression of human T-cell lymphotropic virus type 1 (HTLV-1) Tax: induction of tumor necrosis factor alpha and susceptibility to lysis by CD8+ HTLV-1-specific cytotoxic T cells.: J Virol. 1997 Dec;71(12):9143-9. Unique Identifier : AIDSLINE MED/98037622; Mendez E; Kawanishi T; Clemens K; Siomi H; Soldan SS; Calabresi P; Brady J; Jacobson S; Neuroimmunology Branch, National Institute of Neurologic Diseases and; Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.; Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with a chronic neurological disease termed HTLV-1-associated myelopathy/tropical spastic paraperesis (HAM/TSP). Although the pathogenesis of this disease remains to be elucidated, the evidence suggests that immunopathological mechanisms are involved. Since
Rous sarcoma virus direct repeat cis elements exert effects at several points in the virus life cycle.: J Virol. 1997 Dec;71(12):9150-6. Unique Identifier : AIDSLINE MED/98037623; Simpson SB; Zhang L; Craven RC; Stoltzfus CM; Department of Microbiology, University of Iowa, Iowa City 52242, USA.; Two approximately 135-nucleotide (nt) direct repeats flank the Rous sarcoma virus (RSV) oncogene src and are composed of two smaller repeats, dr1 (approximately 100 nt) and dr2 approximately 36 nt). These sequences have been reported to contain cis-acting signals necessary for RNA packaging and elements that allow cyt
The V3-directed immune response in natural human immunodeficiency virus type 1 infection is predominantly directed against a variable, discontinuous epitope presented by the gp120 V3 domain.: J Virol. 1997 Dec;71(12):9198-205. Unique Identifier : AIDSLINE MED/98037629; Schreiber M; Wachsmuth C; Muller H; Odemuyiwa S; Schmitz H; Meyer S; Meyer B; Schneider-Mergener J; Medical Microbiology Section, Bernhard Nocht Institute for Tropical; Medicine, Hamburg, Germany. mschreib@sgi1.chemie.uni-hamburg.de; The specific binding of antibodies to the V3 loop in sera from human immunodeficiency type 1 (HIV-1)-infected individuals was investigated. Different V3 structures were analyzed as full-length loops or by pepscan. Our data show that on full-length V3 loops, both variable regions on either side of the tip of the loop (
Discontinuous plus-strand DNA synthesis in human immunodeficiency virus type 1-infected cells and in a partially reconstituted cell-free system.: J Virol. 1997 Dec;71(12):9259-69. Unique Identifier : AIDSLINE MED/98037635; Klarmann GJ; Yu H; Chen X; Dougherty JP; Preston BD; Department of Biochemistry, Eccles Institute of Human Genetics and the; Huntsman Cancer Institute, University of Utah, Salt Lake City; 84112-5330, USA.; Human immunodeficiency virus type 1 (HIV-1) replication requires conversion of viral RNA to double-stranded DNA. To better understand the molecular mechanisms of this process, we examined viral DNA synthesis in a simple cell-free system that uses the activities of HIV-1 reverse transcriptase to convert regions of sing
Distinct functions and requirements for the Cys-His boxes of the human immunodeficiency virus type 1 nucleocapsid protein during RNA encapsidation and replication.: J Virol. 1997 Dec;71(12):9295-305. Unique Identifier : AIDSLINE MED/98037639; Schwartz MD; Fiore D; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin; Medical School, Madison 53706, USA.; The process of retroviral RNA encapsidation involves interaction between trans-acting viral proteins and cis-acting RNA elements. The encapsidation signal on human immunodeficiency virus type 1 HIV-1) RNA is a multipartite structure composed of functional stem-loop structures. The nucleocapsid (NC) domain of the Gag p
Human immunodeficiency virus type 1 Vif protein binds to the Pr55Gag precursor.: J Virol. 1997 Dec;71(12):9358-65. Unique Identifier : AIDSLINE MED/98037646; Bouyac M; Courcoul M; Bertoia G; Baudat Y; Gabuzda D; Blanc D; Chazal N; Boulanger P; Sire J; Vigne R; Spire B; INSERM U372, Marseille, France.; The Vif protein of human immunodeficiency virus type 1 is required for productive replication in peripheral blood lymphocytes. Previous reports suggest that vif-deleted viruses are limited in replication because of a defect in the late steps of the virus life cycle. One of the remaining questions is to determine wheth
Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF.: J Virol. 1997 Dec;71(12):9375-82. Unique Identifier : AIDSLINE MED/98037648; Romerio F; Gabriel MN; Margolis DM; Institute of Human Virology, Medical Biotechnology Center, University; of Maryland Biotechnology Institute, Baltimore 21201, USA.; A subpopulation of stably infected CD4+ cells capable of producing virus upon stimulation has been identified in human immunodeficiency virus (HIV)-positive individuals (T.-W. Chun, D. Finzi, J. Margolick, K. Chadwick, D. Schwartz, and R. F. Siliciano, Nat. Med. 1:1284-1290, 1995). Few host factors that directly limit
Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus.: J Virol. 1997 Dec;71(12):9392-9. Unique Identifier : AIDSLINE MED/98037650; Moraleda G; Saputelli J; Aldrich CE; Averett D; Condreay L; Mason WS; Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.; The template for synthesis of hepadnaviral RNAs is a covalently closed circular (ccc) DNA located in the nucleus of the infected hepatocyte. Hepatocytes are normally long-lived and nondividing, and antiviral therapies in chronically infected individuals face the problem of eliminating not only the replicative forms of
Identification of the V1 region as a linear neutralizing epitope of the simian immunodeficiency virus SIVmac envelope glycoprotein.: J Virol. 1997 Dec;71(12):9475-81. Unique Identifier : AIDSLINE MED/98037660; Jurkiewicz E; Hunsmann G; Schaffner J; Nisslein T; Luke W; Petry H; Department of Virology and Immunology, German Primate Centre,; Gottingen.; The sequence variability of viral structure polypeptides has been associated with immune escape mechanisms. The V1 region of simian immunodeficiency virus (SIV) is a highly variable region of the SIVmac env gene. Here, we describe the V1 region as a linear neutralizing epitope. V1 region-specific neutralizing antibodi
The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection.: J Virol. 1997 Dec;71(12):9508-14. Unique Identifier : AIDSLINE MED/98037664; Lifson JD; Nowak MA; Goldstein S; Rossio JL; Kinter A; Vasquez G; Wiltrout TA; Brown C; Schneider D; Wahl L; Lloyd AL; Williams J; Elkins WR; Fauci AS; Hirsch VM; AIDS Vaccine Program, SAIC Frederick, National Cancer; Institute-Frederick Cancer Research and Development Center, Maryland; 21702, USA. lifson@avpvx1.ncifcrf.gov; Different patterns of viral replication correlate with the natural history of disease progression in humans and macaques infected with human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), respectively. However, the viral and host factors influencing these patterns of viral replication i
Infectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinase.: J Virol. 1997 Dec;71(12):9524-30. Unique Identifier : AIDSLINE MED/98037666; Luo T; Livingston RA; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38105, USA.; Nef proteins from human immunodeficiency virus type 1 isolate SF2 HIV-1SF2) and simian immunodeficiency virus isolate mac239 SIVmac239) have been found to associate with a cellular serine/threonine kinase designated NAK. We have recently shown that the association of Nef with NAK is isolate dependent. To identify the
Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus.: J Virol. 1997 Dec;71(12):9531-7. Unique Identifier : AIDSLINE MED/98037667; Luo W; Peterlin BM; Department of Medicine, Microbiology and Immunology, Howard Hughes; Medical Institute, University of California at San Francisco,; 94143-0703, USA.; The Nef from a highly virulent strain of simian immunodeficiency virus (SIV), SIVpbj14, and a Nef from the traditional strain SIVmac239 bearing the mutation from RQ to YE (YE-Nef) both induce an acute lethal disease in monkeys. The YE mutation and its surrounding sequence resemble the immunoreceptor tyrosine-based act
Novel and dynamic evolution of equine infectious anemia virus genomic quasispecies associated with sequential disease cycles in an experimentally infected pony.: J Virol. 1997 Dec;71(12):9627-39. Unique Identifier : AIDSLINE MED/98037678; Leroux C; Issel CJ; Montelaro RC; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.; We have investigated the genetic evolution of three functionally distinct regions of the equine infectious anemia virus (EIAV) genome (env, rev, and long terminal repeat) during recurring febrile episodes in a pony experimentally infected with a well-characterized reference biological clone designated EIAV(PV). Viral
Enhancement of feline immunodeficiency virus (FIV) infection after DNA vaccination with the FIV envelope.: J Virol. 1997 Dec;71(12):9640-9. Unique Identifier : AIDSLINE MED/98037679; Richardson J; Moraillon A; Baud S; Cuisinier AM; Sonigo P; Pancino G; Genetique des Virus et Immunopharmacologie Moleculaire, ICGM-CNRS; UPR415, Institut Cochin de Genetique Moleculaire, Paris, France.; Despite intensive experimentation to develop effective and safe vaccines against the human immunodeficiency viruses and other pathogenic lentiviruses, it remains unclear whether an immune response that does not afford protection may, on the contrary, produce adverse effects. In the present study, the effect of genetic
Direct demonstration of retroviral recombination in a rhesus monkey.: J Virol. 1997 Dec;71(12):9650-3. Unique Identifier : AIDSLINE MED/98037680; Wooley DP; Smith RA; Czajak S; Desrosiers RC; Department of Microbiology and Immunology, Wright State University; School of Medicine, Dayton, Ohio 45435, USA.; Recombination may be an important mechanism for increasing variation in retroviral populations. Retroviral recombination has been demonstrated in tissue culture systems by artificially creating doubly infected cells. Evidence for retroviral recombination in vivo is indirect and is based principally on the identificati
Promonocytic U937 subclones expressing CD4 and CXCR4 are resistant to infection with and cell-to-cell fusion by T-cell-tropic human immunodeficiency virus type 1.: J Virol. 1997 Dec;71(12):9664-71. Unique Identifier : AIDSLINE MED/98037682; Moriuchi H; Moriuchi M; Arthos J; Hoxie J; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-1576, USA.; Different strains of human immunodeficiency virus type 1 (HIV-1) vary markedly in the ability to infect cells of the monocyte/macrophage (M/M) lineage. M/M are generally resistant to infection with T-cell-tropic (T-tropic) strains of HIV-1. Recently, the chemokine receptors CCR5 and CXCR4 were identified as cofactors
Efficient expression by an alphavirus replicon of a functional ribozyme targeted to human immunodeficiency virus type 1.: J Virol. 1997 Dec;71(12):9713-21. Unique Identifier : AIDSLINE MED/98037688; Smith SM; Maldarelli F; Jeang KT; Laboratory of Molecular Microbiology, National Institute of Allergy; and Infectious Diseases, Bethesda, Maryland 20892-0460, USA.; Intracellular applications of ribozymes have been limited partly by the availability of suitable high-expression systems. For RNA effectors, consideration of an RNA virus vector system for delivery and expression is reasonable. We show that alphavirus replicons can be highly efficient nonintegrating ribozyme-expressin
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein.: J Virol. 1997 Dec;71(12):9722-31. Unique Identifier : AIDSLINE MED/98037689; Wyatt R; Desjardin E; Olshevsky U; Nixon C; Binley J; Olshevsky V; Sodroski J; Dana-Farber Cancer Institute, and Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115, USA.; The human immunodeficiency virus type 1 (HIV-1) gp120 exterior envelope glycoprotein interacts with the viral receptor (CD4) and with the gp41 transmembrane envelope glycoprotein. To study the interaction of the gp120 and gp41 envelope glycoproteins, we compared the abilities of anti-gp120 monoclonal antibodies to bin
Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.: J Virol. 1997 Dec;71(12):9732-42. Unique Identifier : AIDSLINE MED/98037690; Withers-Ward ES; Jowett JB; Stewart SA; Xie YM; Garfinkel A; Shibagaki Y; Chow SA; Shah N; Hanaoka F; Sawitz DG; Armstrong RW; Souza LM; Chen IS; Department of Microbiology and Immunology, UCLA School of Medicine,; Los Angeles, California 90095-1678, USA.; The human immunodeficiency virus type 1 (HIV-1) vpr gene is an evolutionarily conserved gene among the primate lentiviruses HIV-1, HIV-2, and simian immunodeficiency viruses. One of the unique functions attributed to the vpr gene product is the arrest of cells in the G2 phase of the cell cycle. Here we demonstrate tha
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.: J Virol. 1997 Dec;71(12):9753-63. Unique Identifier : AIDSLINE MED/98037692; Kolesnitchenko V; King L; Riva A; Tani Y; Korsmeyer SJ; Cohen DI; Division of Basic Sciences, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.; We have investigated the relative contribution of apoptosis or programmed cell death (PCD) to cell killing during acute infection with T-cell-tropic, cytopathic human immunodeficiency virus type 1 (HIV-1), by employing diverse strategies to inhibit PCD or to detect its common end-stage sequelae. When Bcl-2-transfected
A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.: J Virol. 1997 Dec;71(12):9764-9. Unique Identifier : AIDSLINE MED/98037693; Desrosiers RC; Sasseville VG; Czajak SC; Zhang X; Mansfield KG; Kaur A; Johnson RP; Lackner AA; Jung JU; New England Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9102, USA.; A herpesvirus that is related to but distinct from the Kaposi s sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) was isolated from rhesus monkeys. The sequence of 10.6 kbp from virion DNA revealed the presence of an interleukin-6 homolog similar to what is present in KSHV and a closer relatedness of the D
Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.: J Virol. 1997 Dec;71(12):9808-12. Unique Identifier : AIDSLINE MED/98037702; Cao J; Sullivan N; Desjardin E; Parolin C; Robinson J; Wyatt R; Sodroski J; Dana-Farber Cancer Institute, and Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115, USA.; A human immunodeficiency virus type 1 (HIV-1) mutant lacking the V1 and V2 variable loops in the gp120 exterior envelope glycoprotein replicated in Jurkat lymphocytes with only modest delays compared with the wild-type virus. Revertants that replicated with wild-type efficiency rapidly emerged and contained only a few
Reduced viral load and lack of CD4 depletion in SCID-hu mice infected with Rev-independent clones of human immunodeficiency virus type 1.: J Virol. 1997 Dec;71(12):9817-22. Unique Identifier : AIDSLINE MED/98037704; Valentin A; Aldrovandi G; Zolotukhin AS; Cole SW; Zack JA; Pavlakis GN; Felber BK; ABL-Basic Research Program, National Cancer Institute-Frederick Cancer; Research and Development Center, Frederick, Maryland 21702-1201, USA.; The posttranscriptional control element CTE of the simian type D retrovirus has been shown to support replication of Rev-Rev-responsive-element (RRE)-deficient molecular clones of human immunodeficiency virus type 1 (HIV-1). Upon infection of peripheral blood mononuclear cells in vitro, these CTE-containing Rev-indepe
Kaposi's sarcoma associated herpesvirus deoxyribonucleic acid sequences: lack of detection in prostatic tissue of human immunodeficiency virus-negative immunocompetent adults.: J Urol. 1998 Jan;159(1):146-8. Unique Identifier : AIDSLINE MED/98063105; Rubin MA; Parry JP; Singh B; Department of Pathology, College of Physicians and Surgeons of; Columbia University, New York, New York, USA.; PURPOSE: A recent study argued that Kaposi s sarcoma associated herpesvirus is ubiquitous, as reflected by the frequent detection of its deoxyribonucleic acid (DNA) sequences in the prostatic tissue of healthy Italian men. Because these findings are discordant with serological data, our objective was to reassess the p
Randomised, controlled, community-level HIV-prevention intervention for sexual-risk behaviour among homosexual men in US cities. Community HIV Prevention Research Collaborative.: Lancet. 1997 Nov 22;350(9090):1500-5. Unique Identifier : AIDSLINE MED/98049751; Kelly JA; Murphy DA; Sikkema KJ; McAuliffe TL; Roffman RA; Solomon LJ; Winett RA; Kalichman SC; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee 53226, USA.; BACKGROUND: Community-level interventions may be helpful in population-focused HIV prevention. If members of populations at risk of HIV infection who are popular with other members can be engaged to advocate the benefits of behaviour change to peers, decreases in risk behaviour may be possible. We assessed a community
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1546. Unique Identifier : AIDSLINE MED/98049767; Aaby P; Babiker A; Darbyshire J; Nunn A; Barreto S; Alonso P; Badaro R; Barros F; Victoria C; Binka F; Biryahwaho B; Byabamazima C; Sempala S; Tugume B; Kalebu P; Kengeya-Kayondo J; Whitworth J; Paxton L; Convit J; Corrah T; McAdam K; Datta M; Dowlati Y; Fine P; Tanner M; et al
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1546-7. Unique Identifier : AIDSLINE MED/98049768; DeCock K; Shaffer N; Wiktor S; Simonds RJ; Rogers M
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1547. Unique Identifier : AIDSLINE MED/98049770; Cooper PA
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1547. Unique Identifier : AIDSLINE MED/98049769; Semba RD
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1547. Unique Identifier : AIDSLINE MED/98049771; Vaughan W
HIV serophobia in the mortuary: an algorithm system for handling high-risk forensic cases.: Med Sci Law. 1997 Oct;37(4):296-302. Unique Identifier : AIDSLINE MED/98045238; Patel F; UMDS Guy's Hospital, University of London.; A serophobia of the human immunodeficiency virus type 1 (HIV-1) is very noticeable in mortuaries handling high-risk cases. The morbid anxiety about occupationally acquired HIV infection in the forensic practice has made mortuary workers unduly overcautious. Despite the availability of codes of practice and informed pr
Drugs for HIV infection.: Med Lett Drugs Ther. 1997 Dec 12;39(1015):111-6. Unique Identifier : AIDSLINE MED/98066632
Pityrosporum yeasts--what's new?: Mycoses. 1997;40 Suppl 1:29-32. Unique Identifier : AIDSLINE MED/98037226; Faergemann J; Department of Dermatology, Sahlgrenska University Hospital, Goteborg,; Schweden.; The lipophilic yeast Pityrosporum ovale is a member of the normal human cutaneous flora in adults but also associated with several skin diseases. In pityriasis versicolor, under the influence of predisposing factors, P. ovale changes from the round blastospore form to the mycelial form. A great problem in pityriasis v
[High-dose therapy with fluconazole > or = 800 mg/day. Review]: Mycoses. 1997;40 Suppl 1:33-42. Unique Identifier : AIDSLINE MED/98037227; Penk A; Pittrow L; Pfizer GmbH, Abt. Medizin, Karlsruhe, BR Deutschland.; The clinical use of fluconazole in dosages > or = 800 mg/day has been reported in about 900 patients against candidemia, oropharyngeal candidiasis and cryptococcal meningitis in HIV-infected patients as well as for initial therapy of endemic mycoses. Especially in patients with life-threatening infections caused by Ca
[Fluconazole-resistant Candida species from HIV infected patients with recurrent Candida stomatitis: cross resistance to itraconazole and ketoconazole]: Mycoses. 1997;40 Suppl 1:56-63. Unique Identifier : AIDSLINE MED/98037231; Metzger S; Hofmann H; Klinik und Poliklinik fur Dermatologie und Allergologie am; Biederstein, Technische Universitat Munchen, BR Deutschland.; In vitro susceptibility to fluconazole of Candida species isolated from 83 HIV-infected patients treated with fluconazole because of recurrent Candida stomatitis was monitored over a period of two years. A microdilution assay with high-resolution antifungal assay (HR) medium and RPMI 1640-medium were compared. In vitr
[Patterns of Candida esophagitis in cancer and AIDS patients: histopathological study of 23 patients]: Mycoses. 1997;40 Suppl 1:81-5. Unique Identifier : AIDSLINE MED/98037235; Gornig M; Emmert-Buck M; Walsh TJ; Klinik fur Hautkrankheiten, Friedrich-Schiller-Universitat, Jena.; Candida oesophagitis is a common concomitant disease in neutropenic cancer patients after chemotherapie as well as in HIV-patients. In order to characterize the features of oesophagitis in each population, we reviewed the medical history and pathology records of 23 patients (18 cancer-patients, 5 HIV-patients) with cu
Molecular epidemiology of bartonella infections in patients with bacillary angiomatosis-peliosis [see comments]: N Engl J Med. 1997 Dec 25;337(26):1876-83. Unique Identifier : AIDSLINE MED/98057268; Koehler JE; Sanchez MA; Garrido CS; Whitfeld MJ; Chen FM; Berger TG; Rodriguez-Barradas MC; LeBoit PE; Tappero JW; Department of Medicine, University of California, San Francisco; 94143-0654, USA.; BACKGROUND: Bacillary angiomatosis and bacillary peliosis are vascular proliferative manifestations of infection with species of the genus bartonella that occur predominantly in patients infected with the human immunodeficiency virus. Two species, B. henselae and B. quintana, have been associated with
Vaginitis.: N Engl J Med. 1997 Dec 25;337(26):1896-903. Unique Identifier : AIDSLINE MED/98057272; Sobel JD; Department of Internal Medicine, Wayne State University School of; Medicine and Detroit Medical Center, MI, USA.
Of cats, humans, and Bartonella [editorial; comment]: N Engl J Med. 1997 Dec 25;337(26):1916-7. Unique Identifier : AIDSLINE MED/98057275; Tompkins LS
[Cytomegalovirus pneumonia in patients with AIDS treated foscarnet. Our experience]: Minerva Med. 1997 Oct;88(10):411-3. Unique Identifier : AIDSLINE MED/98059226; Terra L; Pellicano S; Calzone R; Mandica D; Milano M; Ospedale S. Giovanni di Dio, Divisione Malattie Infettive, A.S.L. n. 5; Crotone (Regione Calabria).; A case of cytomegalovirus pneumonia occurring in a patient affected with AIDS is reported. The treatment of this disease is still difficult and remission of CHV-pneumonia after therapy with foscarnet is emphasized.
Nematode infection induces Th2 cell-associated immune responses in LEC mutant rats with helper T cell immunodeficiency.: Parasite Immunol. 1997 Oct;19(10):461-8. Unique Identifier : AIDSLINE MED/98039783; Uchikawa R; Matsuda S; Yamada M; Nishida M; Agui T; Arizono N; Department of Medical Zoology, Kyoto Prefectural University of; Medicine, Japan.; Long-Evans Cinnamon (LEC) rats have maturational arrest of CD4+8- T cells from CD4+8+ cells in the thymus. Despite this, CD4+8- T cells are always present in peripheral lymphoid organs of LEC rats, suggesting that these CD4+8- T cells are generated by an uncommon pathway. We investigated the role of LEC rat peripheral
[At the National Academy of Medicine. Desire for pregnancy in the couples with a HIV-seronegative woman and a seropositive partner. A report presented by R. Henrion]: Presse Med. 1997 Oct 4;26(29):1390-1. Unique Identifier : AIDSLINE MED/98068160
[Importance of the use of health protective measures for the prevention of hepatitis B, hepatitis C and HIV infections]: Prof Inferm. 1997 Jan-Mar;50(1):35-6. Unique Identifier : AIDSLINE MED/97391721; Crispo R; Varano A
Human immunodeficiency virus infection and hepatitis: biosafety in radiology.: Radiology. 1997 Dec;205(3):619-28. Unique Identifier : AIDSLINE MED/98055230; Wall SD; Howe JM; Sawhney R; Department of Radiology, University of California-San Francisco, USA.; Radiologists frequently perform invasive diagnostic and therapeutic procedures involving needles and/or vascular access, and often they do so in darkened rooms. Therefore, they are at risk of exposure to blood-borne pathogens. The risk of HIV infection with a single sharp injury is low (0.3%), and on average 99.7% of
[Heart pathology of extracardiac origin (I). Cardiac involvement in AIDS]: Rev Esp Cardiol. 1997 Oct;50(10):721-8. Unique Identifier : AIDSLINE MED/98024831; Guillamon Toran L; Romeu Fontanillas J; Forcada Sainz JM; Curos Abadal A; Larrousse Perez E; Valle Tudela V; Servicio de Cardiologia, Hospital Universitari Germans Trias i Pujol,; Badalona, Barcelona.; A great variety of cardiac disorders have been reported in HIV-infected patients: pericarditis, myocarditis, cardiomyopathies, endocarditis, cardiac involvement through malignancies, pulmonary hypertension, arrhythmias and thromboembolic disease. In general, these disorders are asymptomatic and often diagnosed in echo
Linomide enhances apoptosis in CD4+CD8+ thymocytes.: Scand J Immunol. 1997 Nov;46(5):488-94. Unique Identifier : AIDSLINE MED/98055369; Harring AC; Xu Z; Andersson G; Hedlund G; Pharmacia & Upjohn, Lund Research Center, Sweden.; Linomide, a quinoline-3-carboxamide, has a pleiotropic immune modulating capacity and inhibits development as well as progression of disease in animal models of autoimmunity. Linomide treatment of mice resulted in a dramatic, dose-dependent decrease of the thymic cell number shortly after the start of administration.
Interferon-gamma production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major.: Scand J Immunol. 1997 Nov;46(5):495-9. Unique Identifier : AIDSLINE MED/98055370; Kemp K; Hviid L; Kharazmi A; Kemp M; Centre for Medical Parasitology at RHIMA Centre, Copenhagen University; Hospital, Rigshospitalet, Denmark.; Acquired resistance to both mycobacteria and Leishmania is primarily mediated by interferon-gamma (IFN-gamma), which triggers mechanisms leading to the death of the microorganism in macrophages. In this study, cell activation and IFN-gamma production was investigated in human peripheral blood mononuclear cells (PBMC)
How to diagnose chronic rejection. A study in porcine intestinal allografts.: Scand J Immunol. 1997 Nov;46(5):514-9. Unique Identifier : AIDSLINE MED/98055373; Kuusanmaki P; Lauronen J; Paavonen T; Pakarinen M; Yilmaz S; Hayry P; Halttunen J; Second Department of Surgery, Helsinki University Central Hospital,; University of Helsinki, Helsinki, Finland.; Porcine small bowel allografts were followed for 18 weeks during immunosuppression with cyclosporine-A (CyA), azatioprine and prednisone. The mucosal alterations noted at the 12th week were epithelial vacuolation and loss of Goblet cells. Moderate infiltration of inflammatory cells, mainly lymphocytes, was found in th
T-cell receptor BJ gene segment expression in human umbilical cord blood CD4+ and CD8+ T-cell subsets.: Scand J Immunol. 1997 Nov;46(5):520-6. Unique Identifier : AIDSLINE MED/98055374; Jeddi-Tehrani M; Hodara V; Esin S; Torok C; Wigzell H; Andersson R; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.; By employing RT-PCR-based technology, followed by Southern-blot analysis, patterns of relative TRC BJ gene segment usage in human CD4+ and CD8+ umbilical cord blood T cells (UCT) from ten children were determined in relation to seven recombined TCR BV gene (sub) families (BV 3, 5S1, 6S1-3, 8, 9, 12 and 18). Normal fre
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1969-70; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072191; Parravicini C; Lauri E; Baldini L; Neri A; Poli F; Sirchia G; Moroni M; Galli M; Corbellino M
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1970-1; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072192; Masood R; Zheng T; Tupule A; Arora N; Chatlynne L; Handy M; Whitman J Jr
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1971-2; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072193; Whitby D; Boshoff C; Luppi M; Torelli G
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1972; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072194; Brousset P; Meggetto F; Attal M; Delsol G
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1972; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072195; Cottoni F; Uccini S
Persistent long-term changes in lymphocyte subsets induced by polyclonal antibodies.: Transplantation. 1997 Nov 27;64(10):1432-7. Unique Identifier : AIDSLINE MED/98052200; Muller TF; Grebe SO; Neumann MC; Heymanns J; Radsak K; Sprenger H; Lange H; Department of Nephrology, Philipps-University of Marburg, Germany.; BACKGROUND: Clinicians are well aware of the short-term effects of immunosuppression by mono- or polyclonal antibodies. Little is known about long-term changes induced by these therapies. METHODS: Forty-three renal allograft recipients were selected according to their initial postoperative immunosuppression: (1) BI gr
PGE2 regulation of B lymphocytes and T helper 1 and T helper 2 cells: induction of inflammatory versus allergic responses.: Adv Exp Med Biol. 1997;407:237-42. Unique Identifier : AIDSLINE MED/97463174; Fedyk ER; Brown DM; Phipps RP; Immunology Program, University of Rochester School of Medicine and; Dentistry, New York 14642, USA.
Murine AIDS cured by low dosage total body irradiation.: Adv Exp Med Biol. 1997;407:451-8. Unique Identifier : AIDSLINE MED/97463205; Shen RN; Lu L; Kaiser HE; Broxmeyer HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202-5121, USA.
The therapeutic effect of Naturin-2 on Lewis lung carcinoma and murine-AIDS.: Adv Exp Med Biol. 1997;407:541-9. Unique Identifier : AIDSLINE MED/97463221; Shen RN; Lu L; Jia XQ; Wong ML; Kaiser HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202-5121, USA.
Adolescent AIDS prevention in context: the impact of peer educator qualities and classroom environments on intervention efficacy.: Am J Community Psychol. 1997 Jun;25(3):289-323. Unique Identifier : AIDSLINE MED/97474123; Ozer EJ; Weinstein RS; Maslach C; Siegel D; Psychology Dept., University of California-Berkeley 94720-1650, USA.; emilyjun@socrates.berkeley.edu; Peer-led, school-based interventions show promise for preventing AIDS among adolescents, but little is known about the processes underlying effective peer education or the conditions that promote its efficacy. This study examined the implementation in one school of an effective, peer-led AIDS prevention program for in
Illness-related support and negative network interactions: effects on HIV-infected men's depressive symptomatology.: Am J Community Psychol. 1997 Jun;25(3):395-420. Unique Identifier : AIDSLINE MED/97474126; Siegel K; Raveis VH; Karus D; Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.; Data collected as part of a psychosocial study of gay and bisexual men s experiences of living with HIV infection as a chronic illness were examined to investigate the psychological impact of the perceived availability of illness-related support and negative illness-related network interactions in a sample of men from
Idiopathic colonic inflammation in AIDS: an open trial of prednisone.: Am J Gastroenterol. 1997 Dec;92(12):2237-40. Unique Identifier : AIDSLINE MED/98060682; Gopal DV; Hassaram S; Marcon NE; Kandel G; Department of Pathology, Wellesley Hospital and University of Toronto,; Ontario, Canada.; OBJECTIVES: Idiopathic colonic inflammation and ulceration have been described in HIV infection, but only as isolated case reports. We have been treating this condition with a uniform corticosteroid protocol and now report our results. METHODS: We describe the cases of eight patients with HIV infection who had diarrhe
Thalidomide for AIDS diarrhea?: Am J Gastroenterol. 1997 Dec;92(12):2312-3. Unique Identifier : AIDSLINE MED/98060704; Surawicz CM; University of Washington, Seattle, USA.
Detection of BCL-6 rearrangements and p53 mutations in Malt-lymphomas.: Am J Hematol. 1997 Dec;56(4):206-13. Unique Identifier : AIDSLINE MED/98055558; Gaidano G; Volpe G; Pastore C; Chiarle R; Capello D; Gloghini A; Perissinotto E; Savinelli F; Bosco M; Mazza U; Pileri S; Palestro G; Carbone A; Saglio G; Dipartimento di Scienze Mediche, Universita di Torino, Novara, Italy.; gaidano@med.no.unipmn.it; Twenty-seven lymphomas of mucosa-associated lymphoid tissue MALT) derived from distinct anatomical sites were tested for the presence of genetic lesions commonly involved in B-cell lymphomagenesis, including activation of proto-oncogenes (BCL-1, BCL-2, BCL-6, and c-MYC), disruption of tumor suppressor loci p53, 6q), a
Parvovirus B19 quiescence during the course of human immunodeficiency virus infection in persons with hemophilia.: Am J Hematol. 1997 Dec;56(4):248-51. Unique Identifier : AIDSLINE MED/98055565; Goedert JJ; Erdman DD; Konkle BA; Torok TJ; Lederman MM; Kleinert D; Mandalaki T; Kessler CM; Anderson LJ; Luban NL; Viral Epidemiology Branch, National Cancer Institute, Rockville,; Maryland, USA. jg8s@nih.gov; To detect and characterize parvovirus B19 infection during the course of progressive immune deficiency from human immunodeficiency virus (HIV), ten subjects enrolled in the Multicenter Hemophilia Cohort Study were followed for 6.4 to 15 years from HIV seroconversion through extreme immune deficiency. Four to five sera
Oncotic pressure and edema formation in hypoalbuminemic HIV-infected patients with proteinuria.: Am J Kidney Dis. 1997 Dec;30(6):822-8. Unique Identifier : AIDSLINE MED/98058875; Guardia JA; Ortiz-Butcher C; Bourgoignie JJ; Department of Medicine, University of Miami/Jackson Memorial Hospital,; FL 33101, USA.; Human immunodeficiency virus nephropathy (HIVN) continues to challenge nephrologic consultative services at major urban institutions. Although noted in the literature, the decreased incidence of peripheral edema in HIVN has been unexplained to date. In HIV patients, total proteins frequently are found to be elevated d
HIV & breastfeeding: a model for sensitive midwifery.: J Aust Coll Midwives. 1997 Sep;10(3):27-31. Unique Identifier : AIDSLINE MED/98045393; Comerford KM; The following article forms part of an overall submission which assisted the author in winning the 1996 Victorian Irving Buzzard Prize. It explores important present day issues of HIV and Breastfeeding and provides an overview of a developed Model designed to help the Midwife sensitively and informatively assist the H
Complement in human disease.: Immunol Today. 1997 Oct;18(10):460-3. Unique Identifier : AIDSLINE MED/98019984; Wurzner R; Dierich MP; Institut fur Hygiene, University of Innsbruck, Austria.
Th1-type immunity is incompatible with successful pregnancy.: Immunol Today. 1997 Oct;18(10):478-82. Unique Identifier : AIDSLINE MED/98019988; Raghupathy R; Dept. of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.; Raj@hscc.kuniv.edu.kw; Several years ago, the rather provocative question was raised: is successful pregnancy a T helper 2 (Th2) phenomenon? Implicit in this argument is the corollary that unsuccessful pregnancy is a Th1-type situation. Here, evidence from murine and human pregnancy is presented to show that, since Th1-type cytokines mediat
Blind T-cell homeostasis and HIV infection [letter]: Immunol Today. 1997 Oct;18(10):505-7. Unique Identifier : AIDSLINE MED/98019994; Cole S
Paternal leukocytes selectively increase secretion of IL-4 in peripheral blood during normal pregnancies: demonstrated by a novel one-way MLC measuring cytokine secretion.: Am J Reprod Immunol. 1997 Nov;38(5):320-6. Unique Identifier : AIDSLINE MED/98013277; Ekerfelt C; Matthiesen L; Berg G; Ernerudh J; Department of Neurology, University Hospital, Linkoping, Sweden.; PROBLEM: It has been proposed that immune responses in normal pregnancy are Th2-like, thereby protecting the fetus and placenta from being rejected. Some studies have shown Th2-deviated systemic responses to different antigens and mitogens. The aim of this study was to demonstrate the specific T cell cytokine response
Sequence variations between two Epstein-Barr virus LMP 1 variants have no effect on the activation of NF-kappaB activity.: DNA Cell Biol. 1997 Nov;16(11):1311-9. Unique Identifier : AIDSLINE MED/98068838; Yeh TS; Li SN; Wu CJ; Liu ST; Meng CL; Chang YS; Graduate Institute of Microbiology and Immunology, National Yang-Ming; University, Shih-pai, ROC.; Previously, we reported that the LMP 1 gene of Epstein-Barr virus EBV) derived from nasopharyngeal carcinoma (NPC) tissues (i.e., NLMP 1 gene) was able to transform BALB/c3T3 cells. On the other hand, LMP 1 gene of B95-8 strain (i.e., BLMP 1 gene) was not able to transform these cells (Chen et aL, 1992). Further studi
[Data-sets as flexible tool in nursing plans. Care of patients with HIV/AIDS benefited by clearness]: TVZ. 1997 May 3;107(9):262-5. Unique Identifier : AIDSLINE MED/98079826; van Zelm R; ten Napel H; Aids-afdeling van het AMC.
IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 mice.: Am J Respir Cell Mol Biol. 1997 Dec;17(6):733-9. Unique Identifier : AIDSLINE MED/98072218; Hoag KA; Lipscomb MF; Izzo AA; Street NE; Cancer Immunobiology Center and Department of Microbiology, University; of Texas Southwestern Medical Center, Dallas 75235-8576, USA.; A murine model was used to assess the role of cytokines in initiating protective T-cell-mediated immunity in the lung. A pulmonary infection was initiated by intratracheal inoculation of Cryptococcus neoformans (Cne). Previously, we had established that Cne lung clearance was mouse-strain-specific: C.B-17 mice were re
Spread of HIV from non-drug user to non-drug user [letter]: Br J Gen Pract. 1997 Sep;47(422):595. Unique Identifier : AIDSLINE MED/98069582; Wyld R; Robertson R; Gillon J
Use of a green fluorescent protein as a marker for human immunodeficiency virus type 1 infection.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1077-81. Unique Identifier : AIDSLINE MED/97426107; Page KA; Liegler T; Feinberg MB; Gladstone Institute of Virology and Immunology and the Department of; Microbiology and Immunology, University of California, San Francisco; 94141, USA.; We constructed a recombinant human immunodeficiency virus type 1 HIV-1) provirus called R7-GFP that expresses a modified form of a green fluorescent protein (GFP) from the jellyfish Aequorea victoria by substituting GFP-coding sequences for Nef-coding sequences. Alanine was substituted for serine at amino acid positio
Didanosine but not high doses of hydroxyurea rescue pigtail macaque from a lethal dose of SIV(smmpbj14).: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1083-8. Unique Identifier : AIDSLINE MED/97426108; Lori F; Gallo RC; Malykh A; Cara A; Romano J; Markham P; Franchini G; Basic Research Laboratory, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; It has been previously reported that hydroxyurea (HU) displays anti-HIV-1 activity and potentiates the antiviral effects of didanosine (ddI) in vitro. To assess the antiviral efficacy of HU in an animal model, the effects of HU and ddI, either individually or as combinatio
Decrease in phosphocreatine level in skeletal muscle of SIV-infected rhesus macaques correlates with decrease in intracellular glutathione.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1089-91. Unique Identifier : AIDSLINE MED/97426109; Hack V; Gross A; Bohme A; Stahl-Hennig C; Droge W; Department of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Loss of skeletal muscle tissue (cachexia) is one of the hallmarks of HIV infection. It has been found (1) that creatine kinase, i.e., an enzyme of pivotal importance in muscular mitochondrial energy metabolism, is inhibited by oxidative glutathiolation, and 2) that reduced glutathione (GSH) is decreased in skeletal mu
Antiretroviral effect of combined zidovudine and reduced glutathione therapy in murine AIDS.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1093-9. Unique Identifier : AIDSLINE MED/97426110; Magnani M; Fraternale A; Casabianca A; Schiavano GF; Chiarantini L; Palamara AT; Ciriolo MR; Rotilio G; Garaci E; Institute of Biological Chemistry Giorgio Fornaini, University of; Urbino, Italy. magnani@bib.uniurb.it; A combination of antiretroviral drugs acting at different points in the virus replication cycle was evaluated in a murine retrovirus-induced immunodeficiency model of AIDS (MAIDS). Intramuscular administration of high doses of reduced glutathione GSH, 100 mg/mouse/day) and
Structural and functional analysis of negatively charged milk proteins with anti-HIV activity.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1101-7. Unique Identifier : AIDSLINE MED/97426111; Berkhout B; Derksen GC; Back NK; Klaver B; de Kruif CG; Visser S; Department of Human Retrovirology, Academic Medical Center, University; of Amsterdam, The Netherlands. B.Berkhout@AMC.UVA.NL; Several polyanionic reagents such as dextran sulfates, heparin sulfates, and negatively charged proteins have been reported to exhibit anti-HIV activity in vitro. Particularly potent inhibition has been reported for the milk protein beta-lactoglobulin (betaLG) on modification by 3-hydroxyphthalic anhydride (3HP). The
Production and characterization of monoclonal antibodies to simian immunodeficiency virus envelope glycoproteins.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1109-19. Unique Identifier : AIDSLINE MED/97426112; Babas T; Le Grand R; Dormont D; Bahraoui E; Laboratoire d'Immunovirologie des Lentivirus des Primates, UFR SVT,; Universite Paul Sabatier, Toulouse, France.; Twelve monoclonal antibodies (MAbs), TB1 to TB12, were produced against a soluble vaccinia recombinant envelope glycoprotein gp140) from simian immunodeficiency virus SIVmac251. These MAbs recognized SIV gp140 with a relatively high affinity (K0.5 from 6.7 x 10(-8) to 4 x 10(-9) M). All the MAbs except TB9, TB11, and
Most potential linear B cell epitopes of Env glycoproteins of feline immunodeficiency virus are immunogenically silent in infected cats.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1121-9. Unique Identifier : AIDSLINE MED/97426113; Massi C; Lombardi S; Indino E; Matteucci D; La Rosa C; Esposito F; Garzelli C; Bendinelli M; Retrovirus Center, Department of Biomedicine, University of Pisa,; Italy.; A battery of sixty-six 20- to 23-amino acid synthetic peptides, partially overlapping by 10-12 amino acids, spanning the entire sequence of the envelope (Env) glycoproteins of the Petaluma isolate of feline immunodeficiency virus (FIV-Pet), has been used to map Env linear B cell epitopes. By screening FIV-infected cat
Cortical cell loss in asymptomatic cats experimentally infected with feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1131-40. Unique Identifier : AIDSLINE MED/97426114; Meeker RB; Thiede BA; Hall C; English R; Tompkins M; Department of Neurology, University of North Carolina, Chapel Hill; 27599, USA.; Specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) were used to evaluate the development of central nervous system changes during the asymptomatic stages of viral infection. The brains of asyptomatic cats were examined at postinoculation times ranging from 8 weeks to 3 years f
High prevalence of false-negative anti-HTLV type I/II enzyme-linked immunosorbent assay results in HIV type 1-positive patients.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1141-6. Unique Identifier : AIDSLINE MED/97426115; Zehender G; De Maddalena C; Gianotto M; Cavalli B; Santambrogio S; Orso M; Moroni M; Galli M; Clinica delle Malattie Infettive, Universita di Milano, Milan, Italy.; zehender@imiucca.csi.unimi.it; A high frequency of false-negative anti-HTLV-I/II ELISA results has been reported by several authors. To verify the possible underestimate of the prevalence of HTLV-II infection in subjects infected by HIV-1, we used the PCR to investigate the presence of HTLV DNA in peripheral blood mononuclear cells (PBMCs) collecte
Detection of simian T cell leukemia virus type I infection in seronegative macaques.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1147-53. Unique Identifier : AIDSLINE MED/97426116; Liska V; Fultz PN; Su L; Ruprecht RM; Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; Simian species of Asian and African origin are naturally infected with the simian T cell leukemia virus type I (STLV-I). Like the closely related human T cell leukemia virus type I (HTLV-I), STLV-I is primarily cell associated, and typical infections exhibit low viral burdens. Four macaques experimentally inoculated w
Genetic analysis of HIV type 1 group O p24gag sequences from Cameroon and Equatorial Guinea.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1155-8. Unique Identifier : AIDSLINE MED/97426117; Hackett J Jr; Zekeng L; Brennan CA; Lund JK; Vallari AS; Hickman RK; Gurtler L; Kaptue L; Devare SG; AIDS Research and Retrovirus Discovery, Abbott Laboratories, North; Chicago, Illinois 60064, USA.
Sequence of chemokine receptor gene CCR5 in chimpanzees, a natural HIV type 1 host.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1159-61. Unique Identifier : AIDSLINE MED/97426118; Zacharova V; Zachar V; Goustin AS; Center for Molecular Medicine and Genetics, Wayne State University,; Detroit, Michigan 48202-3917, USA.
Dynamics of syncytium-inducing and non-syncytium-inducing type 1 human immunodeficiency viruses during primary infection.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1447-51. Unique Identifier : AIDSLINE MED/98051109; Rodrigo AG; Department of Microbiology, University of Washington, Seattle; 98195-7740, USA. rodrigo@u.washington.edu; Syncytium-inducing (SI) type 1 human immunodeficiency viruses HIV-1) replicate faster in vitro and are generally more cytopathic to T cells than non-syncytium-inducing (NSI) HIV-1. Early in infection, the virus population typically consists of NSI viruses, with SI viruses appearing later. This is true even when both S
Thy/Liv-SCID-Hu mice implanted with human intestine: an in vivo model for investigation of mucosal transmission of HIV.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1453-60. Unique Identifier : AIDSLINE MED/98051110; Gibbons C; Kollmann TR; Pettoello-Mantovani M; Kim A; Goldstein H; Department of Pediatrics, Albert Einstein College of Medicine, Bronx,; New York 10461, USA.; Mucosal transmission is a major route by which individuals become infected with HIV. Investigation into the mechanism by which mucosal transmission of HIV occurs would be greatly facilitated by the development of a small animal model infectible with HIV by the mucosal route. We have previously described a SCID-hu mous
Human immunodeficiency virus type 1 glycoprotein 120-specific T lymphocytes provide intermolecular help for anti-CD4 autoantibody production in exposed uninfected subjects.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1461-9. Unique Identifier : AIDSLINE MED/98051111; Furci L; Beretta A; Siccardi A; Lazzarin A; Confetti C; Magnani Z; Scarpellini P; Lopalco L; Burastero SE; Department of Biological and Technological Research (DIBIT), San; Raffaele Scientific Institute, Milan, Italy.; Anti-CD4 antibodies have been documented in about 10-20% of HIV-infected patients. This autoimmune response could be triggered by increased CD4 processing and unveiling of hidden cryptic) epitopes. Multiple markers of exposure to HIV have been described in exposed uninfected individuals. Here, we investigated the mech
Restricted specificity of anti-V3 antibodies induced in humans by HIV candidate vaccines.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1471-85. Unique Identifier : AIDSLINE MED/98051112; Coeffier E; Excler JL; Kieny MP; Meignier B; Moste C; Tartaglia J; Pialoux G; Salmon-Ceron D; Leclerc C; Unite de Biologie des Regulations Immunitaires, Institut Pasteur,; Paris, France.; We analyzed the fine specificity of anti-V3 antibodies elicited in three different species (human, guinea pig, and macaque) by various HIV candidate vaccines. Following immunization with recombinant canarypox virus expressing gp160MN or with recombinant gp160MN/LAI, this antibody response was shown to be directed agai
Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1487-95. Unique Identifier : AIDSLINE MED/98051113; Berglund P; Quesada-Rolander M; Putkonen P; Biberfeld G; Thorstensson R; Liljestrom P; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; Infection of macaques with chimeric simian-human immunodeficiency viruses (SHIVs) allows evaluation of HIV-1 envelope vaccines. SHIV-4 is based on SIVmac239 but carries the env, tat, and rev genes of HIV-1IIIB. In this study we used Semliki Forest virus SFV) RNA vectors to express the envelope protein gp160 of HIV-1II
Immunogenicity of recombinant vaccinia viruses that display the HIV type 1 envelope glycoprotein on the surface of infectious virions.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1497-500. Unique Identifier : AIDSLINE MED/98051114; Katz E; Moss B; Department of Virology, Hebrew University-Hadassah Medical School,; Jerusalem, Israel. katzeh@cc.huji.ac.il; A chimeric protein, consisting of the extracellular domain of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein attached to the transmembrane and cytoplasmic domains of the vaccinia virus B5R glycoprotein, is displayed on the surface of extracellular recombinant vaccinia virus particles, whereas th
Study of spontaneous apoptosis in HIV+ patients: correlation with clinical progression and T cell loss.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1501-8. Unique Identifier : AIDSLINE MED/98051115; Prati E; Gorla R; Malacarne F; Airo P; Brugnoni D; Gargiulo F; Tebaldi A; Castelli F; Carosi G; Cattaneo R; Clinical Immunology Unit, Spedali Civili, Brescia, Italy.; In vitro spontaneous apoptosis (SA) of lymphocytes was studied in HIV infection to evaluate possible clinical and prognostic correlations, in a transsectional study of 101 individuals in different clinical categories and in a prospective longitudinal study of 18 asymptomatic individuals (mean follow-up, 17.2 months).
Downregulation of HLA class I antigen expression in CD4+ T lymphocytes from HIV type 1-infected individuals.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1509-16. Unique Identifier : AIDSLINE MED/98051116; Puppo F; Brenci S; Bosco O; Lanza L; Barocci S; Nocera A; Ghio M; Contini P; Setti M; Scudeletti M; Indiveri F; Department of Internal Medicine, University of Genova, Italy.; The expression of HLA class I antigens is downregulated in CD4+ T cells following in vitro HIV-1 infection. We determined whether the expression of HLA class I antigens is downmodulated in peripheral blood lymphocytes (PBLs) of HIV-1-positive subjects and whether this defect correlates with disease progression. A coho
Inhibition of plating of human T cell leukemia virus type I and syncytium-inducing types of human immunodeficiency virus type 1 by polycations.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1517-23. Unique Identifier : AIDSLINE MED/98051117; Haraguchi Y; Takeuchi Y; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Maebashi, Japan.; We examined the effects of polycations, namely, diethylaminoethyl-dextran (DEAE-dextran) and hexadimethrine bromide (Polybrene), on infection with the retroviruses human T cell leukemia virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus type 1 (HIV-1). The plating of vesicular stomatitis virus
A synthetic peptide corresponding to the carboxy terminus of human immunodeficiency virus type 1 transmembrane glycoprotein induces alterations in the ionic permeability of Xenopus laevis oocytes.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1525-32. Unique Identifier : AIDSLINE MED/98051118; Comardelle AM; Norris CH; Plymale DR; Gatti PJ; Choi B; Fermin CD; Haislip AM; Tencza SB; Mietzner TA; Montelaro RC; Garry RF; Graduate Program in Molecular and Cellular Biology, Tulane University,; New Orleans, Louisiana 70112, USA.; The carboxy-terminal 29 amino acids of the human immunodeficiency virus type 1 transmembrane glycoprotein (HIV-1 TM) are referred to as lentivirus lytic peptide 1 (LLP-1). Synthetic peptides corresponding to LLP-1 have been shown to induce cytolysis and to alter the permeability of cultured cells to various small mole
Effects of tapering doses of oral prednisone on viral load among HIV-infected patients with unexplained weight loss.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1533-7. Unique Identifier : AIDSLINE MED/98051119; Kilby JM; Tabereaux PB; Mulanovich V; Shaw GM; Bucy RP; Saag MS; Center for AIDS Research, Department of Pathology, University of; Alabama at Birmingham School of Medicine, 35294, USA.; In an exploratory study of virologic and immunomodulatory effects of corticosteroid therapy for wasting syndrome, four HIV-infected adults with recent unexplained weight loss were given tapering doses of prednisone over a 2-month period. Serum neopterin and TNF receptor II levels decreased from baseline after 7 days.
Diversity and distribution of gag and env subtypes among 146 HIV type 1 isolates in Taiwan.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1539-43. Unique Identifier : AIDSLINE MED/98051120; Chang KS; Lin CI; Salminen MO; Liao SK; Wu AM; Lin HC; Lin RY; Twu SC; Graduate Institute of Clinical Medicine, Chang Gung Medical College,; Taoyuan-Hsien, Taiwan.
Phylogenetic analysis of a simian T lymphotropic virus type I from a hamadryas baboon.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1545-8. Unique Identifier : AIDSLINE MED/98051121; Liu HF; Goubau P; Van Brussel M; Desmyter J; Vandamme AM; Rega Institute for Medical Research and University Hospitals,; Katholieke Universiteit Leuven, Belgium.
Long-term treatment with recombinant interferon alpha-2b prolongs survival of asymptomatic HIV-infected individuals.: Biotherapy. 1997;10(2):107-13. Unique Identifier : AIDSLINE MED/98041066; Rivero J; Fraga M; Cancio I; Cuervo J; Lopez-Saura P; Sanatorio Santiago de las Vegas, La Habana, Cuba.; RATIONALE AND OBJECTIVE: Early long-term treatment with recombinant interferon (IFN) alpha-2b delayed disease progression in asymptomatic Human Immunodeficiency Virus (HIV) carriers in a randomized trial that lasted from October 1987 to February 1992 14). The aim of the work reported in this paper was to observe if th
Alcohol, tobacco and recreational drug use and the risk of non-Hodgkin's lymphoma.: Br J Cancer. 1997;76(11):1532-7. Unique Identifier : AIDSLINE MED/98062126; Nelson RA; Levine AM; Marks G; Bernstein L; Department of Preventive Medicine, School of Medicine, University of; Southern California, Los Angeles 90033, USA.; A population based case-control study was conducted to determine whether risk of non-Hodgkin s lymphoma (NHL) in the absence of HIV infection is related to the previous use of tobacco, alcohol or recreational drugs. A total of 378 residents of Los Angeles County who were diagnosed
Altered effector responses of H-Y transgenic CD8+ cells.: Int Immunol. 1997 Oct;9(10):1423-30. Unique Identifier : AIDSLINE MED/98013624; Arsov I; Vukmanovic S; Michael Heidelberger Division of Immunology, Department of Pathology,; NYU Medical Center, NY 10016, USA.; The primary role of CD8+ T cells is to destroy virus-infected or tumor cells expressing cognate antigens in the form of peptide-MHC class I complexes. This destruction is primarily achieved by the actions of lytic mediators and/or lymphokines. In this report, we show that mature, H-Y/Db-specific CD8+ T cells from H-Y
Control of TCR V alpha-mediated positive repertoire selection and alloreactivity by differential J alpha usage and CDR3 alpha composition.: Int Immunol. 1997 Oct;9(10):1441-52. Unique Identifier : AIDSLINE MED/98013626; Torres-Nagel N; Deutschlander A; Herrmann T; Arden B; Hunig T; Institute for Virology and Immunobiology, University of Wurzburg,; Germany.; In rats expressing the f allele of the rat MHC (RT1f), CD8 T cells utilizing the V alpha 8.2 segment are 10-fold overselected during thymic development, resulting in V alpha 8.2 expression by 14% of mature CD8 T cells as compared to 1-2% in MHC congenic strains. In the alloreactive responses of CD8 T cells from RT1f-n
Exposure of resting peripheral blood T cells to HIV-1 particles generates CD25+ killer cells in a small subset, leading to induction of apoptosis in bystander cells.: Int Immunol. 1997 Oct;9(10):1453-62. Unique Identifier : AIDSLINE MED/98013627; Kameoka M; Suzuki S; Kimura T; Fujinaga K; Auwanit W; Luftig RB; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; Apoptosis is a major mechanism whereby HIV-1 depletes uninfected CD4+ and CD8+ T cells. We previously showed that resting peripheral blood T cells derived from healthy donors were killed by an apoptotic mechanism after adsorption to gp120-containing, protease-defective HIV-1 (L-2) particles, more effectively than pare
Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression.: Int Immunol. 1997 Oct;9(10):1527-36. Unique Identifier : AIDSLINE MED/98013635; Chidgey A; Boyd R; Department of Pathology and Immunology, Monash Medical School,; Prahran, Melbourne, Australia.; Engagement of the TCR is a pivotal step in thymocyte development, ultimately resulting in the survival (positive selection) or loss negative selection) of developing T cells. The roles of peptides and stromal cell interactions necessary for these selection events, however, are still poorly understood. To investigate t
Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ.: Int Immunol. 1997 Oct;9(10):1601-5. Unique Identifier : AIDSLINE MED/98013643; Koniaras C; Bennett SR; Carbone FR; Heath WR; Lew AM; Walter and Eliza Hall Institute of Medical Research, PO Royal; Melbourne Hospital, Victoria, Australia.; The ultimate fate of T cells undergoing antigen-induced cell death in vivo remains controversial. Whereas apoptosis of CD4+ T cells driven by superantigen is readily detectable in lymphoid organs, CD8+ T cells have been reported to disappear from the lymphoid organs and accumulate in the liver where they undergo apopt
Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.: Biochemistry. 1997 Nov 25;36(47):14384-91. Unique Identifier : AIDSLINE MED/98062905; Engen JR; Smithgall TE; Gmeiner WH; Smith DL; Department of Chemistry, University of Nebraska-Lincoln 68588-0304,; USA.; Protein unfolding on a fast time scale (milliseconds-minutes) has been widely reported, but slower unfolding events (10 min-hours) have received less attention. Amide hydrogen exchange (HX) and mass spectrometry (MS) were used to investigate the unfolding dynamics of the hematopoietic cell kinase (Hck) SH3 domain. Ana
Role of glutamine-151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis.: Biochemistry. 1997 Nov 25;36(47):14430-8. Unique Identifier : AIDSLINE MED/98062910; Kaushik N; Harris D; Rege N; Modak MJ; Yadav PN; Pandey VN; Department of Biochemistry and Molecular Biology, UMD-New Jersey; Medical School, Newark 07103, USA.; Glutamine-151 of HIV-1 RT has been shown to be a catalytically important residue through the characterization of its mutant phenotype Glu151Ala (Sarafianos et al., 1995a). To further understand the role of this residue, we have extended this analysis to include polymerization on natural RNA template in addition to DNA
RNA secondary structure switching during DNA synthesis catalyzed by HIV-1 reverse transcriptase.: Biochemistry. 1997 Dec 2;36(48):14778-85. Unique Identifier : AIDSLINE MED/98066428; Suo Z; Johnson KA; Department of Biochemistry and Molecular Biology, Pennsylvania State; University, University Park 16802, USA.; Changes in RNA secondary structure have been found to play important roles in translational regulation, protein synthesis, and mRNA splicing. In studies utilizing a 66 nucleotide RNA template with a stable hairpin structure, we have examined the effects of RNA secondary structure on HIV-1 reverse transcriptase activit
Adolescent under enrollment in national clinical research: it is time to ask why [comment]: J Adolesc Health. 1997 Dec;21(6):374-5. Unique Identifier : AIDSLINE MED/98065417; Rogers AS; Adolescent, and Maternal AIDS Branch, Center for Research for Mothers; and Children, National Institute of Child Health and Human; Development, Bethesda, Maryland, USA.
Quality of life in HIV-infected women in the south-eastern United States.: AIDS Care. 1997 Oct;9(5):501-12. Unique Identifier : AIDSLINE MED/98068204; Sowell RL; Seals BF; Moneyham L; Demi A; Cohen L; Brake S; College of Nursing, University of South Carolina, Columbia 29204, USA.; The purpose of this study was to evaluate the relative importance of social (social support, material resources, disclosure, and family functioning) and psychological factors (stigma, emotional distress, intrusion, avoidance, and fatalism) as predictors of the quality of life of women infected with HIV. The cross-sect
A survey of women with HIV about their expectations for care.: AIDS Care. 1997 Oct;9(5):513-22. Unique Identifier : AIDSLINE MED/98068205; Meredith K; Delaney J; Horgan M; Fisher E Jr; Fraser V; Washington University School of Medicine, St Louis, Missouri 63110,; USA. kmeredit@imgate.wustl.edu; As an increasing number of women become infected with the human immunodeficiency virus (HIV), it is important to understand their expectations regarding the health care services they receive. In 1995 a new centre was opened at an academic centre in St Louis, Missouri, to provide comprehensive care to women with HIV. T
Trauma of discovery: women's narratives of being informed they are HIV-infected.: AIDS Care. 1997 Oct;9(5):523-38. Unique Identifier : AIDSLINE MED/98068206; Stevens PE; Tighe Doerr B; University of Wisconsin-Milwaukee School of Nursing 53201, USA.; The purposes of this research report are to describe women s subjective experiences of being informed of a positive HIV antibody test and, from their point of view, to explain the meaning and impact of discovering that one is HIV-infected. In this qualitative narrative study, a racially diverse, low-income sample of 3
Vulnerability on the streets: female sex workers and HIV risk.: AIDS Care. 1997 Oct;9(5):539-47. Unique Identifier : AIDSLINE MED/98068207; Pyett PM; Warr DJ; Centre for the Study of Sexually Transmissible Diseases, La Trobe; University, Carlton, Victoria, Australia. P.Pyett@lure.latrobe.edu.au; In-depth interviews were conducted with 24 purposively selected female sex workers who were perceived to be vulnerable to risks associated with their lifestyle and occupation. Brothel workers were found to be considerably less exposed to risk than the women working on the streets. Client resistance was the major obsta
'Appropriate' male and female safer sexual behaviour in heterosexual relationships.: AIDS Care. 1997 Oct;9(5):549-61. Unique Identifier : AIDSLINE MED/98068208; Buysse A; Van Oost P; University of Ghent, Belgium. Ann.Buysse@rug.ac.be; This paper is an attempt to explore how traditional gender role socialization runs counter to safer sexual practices. Structured interviews (N = 448 sexual encounters) were conducted with heterosexual young adults in natural settings such as summer music festivals and youth houses/youth clubs. Congruent with a persp
Concomitants of HIV/STD risk behaviours and intention to engage in risk behaviours in adolescents in India.: AIDS Care. 1997 Oct;9(5):563-75. Unique Identifier : AIDSLINE MED/98068209; Mathai R; Ross MW; Hira S; School of Public Health, University of Texas, Houston 77225, USA.; A total of 1230 year 11 and 12 anglophone college students, modal age 16 and 17, in three colleges in Mumbai (Bombay), India , were studied with regard to sexual behaviours or risk of sexual behaviours, beliefs about sex, HIV/STD knowledge, and perceived norms regarding sexual behavi
Prevention of vertical HIV transmission with zidovudine: projected impact of HIV testing and prenatal care.: AIDS Care. 1997 Oct;9(5):577-88. Unique Identifier : AIDSLINE MED/98068210; Turner BJ; McKee-Nelsen L; Fanning TR; Hauck WW; Division of General Internal Medicine, Jefferson Medical College,; Philadelphia, PA, USA.; We sought to estimate the impact of maternal HIV testing and prenatal care on the potential to reduce vertical transmission through zidovudine ( AZT ) use by HIV-infected mothers. We evaluated the prepartum maternal HIV diagnosis rate, prenatal care, di
Disclosing HIV status and sexual orientation to employers.: AIDS Care. 1997 Oct;9(5):589-99. Unique Identifier : AIDSLINE MED/98068211; Simoni JM; Mason HR; Marks G; Ferkauf Graduate School of Psychology/Yeshiva University, Albert; Einstein College of Medicine, Bronx, NY 10461-1602, USA.; jms112@columbia.edu; Seropositive gay and bisexual men who reveal their sexual orientation or HIV/AIDS status to their employer risk discriminatory reprisals. However, non-disclosure may limit potential social, emotional, and tangible support. Among our sample of 389 seropositive gay and bisexual men employed in the US, 52% were out to
Caring for patients with HIV disease: the experience of a generic hospice.: AIDS Care. 1997 Oct;9(5):601-7. Unique Identifier : AIDSLINE MED/98068212; Gibbs LM; Ellershaw JE; Williams MD; St Christopher's Hospice, London, UK.; This study describes the experience of a generic hospice admitting people with advanced HIV disease over a 4-year period. Data were collected retrospectively for all patients with HIV disease admitted. The aim of the study was to review the number of referrals, the reason for referral, subsequent symptom control and m
Parental HIV discordancy and its impact on the family.: AIDS Care. 1997 Oct;9(5):609-15. Unique Identifier : AIDSLINE MED/98068213; White J; Melvin D; Moore C; Crowley S; St Mary's Hospital, London, UK.; There is little or no available information on the effect of HIV discordancy in heterosexual relationships on different family members. A review of case notes was carried out on all families who had a child referred to the paediatric HIV service/family clinic at St Mary s Hospital between January 1991 and March 1996.
World Health Organization global AIDS statistics.: AIDS Care. 1997 Oct;9(5):625-32. Unique Identifier : AIDSLINE MED/98077168
[Analysis of the microbiological information derived from the sentinel laboratory network for the monitoring of the human immunodeficiency virus infection in Catalonia (1989-1995)]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):401-6. Unique Identifier : AIDSLINE MED/98064465; Blanch C; Vall M; Casabona J; Centre d'Estudis Epidemiologics sobre la VIH/sida a Catalunya; CEESCAT), Hospital Universitari Germans Trias i Pujol, Badalona,; Barcelona.; BACKGROUND: The epidemiologic information on AIDS derived exclusively from the AIDS case registry presents a series of limitations. To solve some of these epidemiologic surveillance systems of HIV infection have been designed. The information of the microbiology laboratories in which anti-HIV antibody detection tests
[Spanish bibliographic production on AIDS. Bibliometric approach]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):407-10. Unique Identifier : AIDSLINE MED/98064466; Osca J; Instituto de Estudios Documentales e Historicos sobre la Ciencia,; Facultad de Medicina, Universidad de Valencia, CSIC.; BACKGROUND: We analyze Spanish production of the books published in Spain about AIDS and they are put together in the database ISBN. METHODS: For every book there considered various things: author, year of publication, ISBN classification, language, edition, place publicated and pub
[Historical cohort study on bacterial pneumonias as predictors of the progression of the human immunodeficiency virus disease]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):418-21. Unique Identifier : AIDSLINE MED/98064469; Teira R; Virosta M; Munoz J; Zubero Z; Cisterna R; Santamaria JM; Seccion de Enfermedades Infecciosas, Hospital de Basurto, Bilbao.; BACKGROUND: Recognition of the importance of bacterial pneumonias in the context of HIV infection has continuously grown throughout the pandemia. It has recently been suggested that these may be predictors of progression of the disease. PATIENTS AND METHODS: The evolution of an historic cohort of patients with HIV inf
[Pulmonary condensation in a patient with AIDS]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):429-30. Unique Identifier : AIDSLINE MED/98064473; Elejalde JI; Reparaz J; Castiello J; Uriz J; Sola J; Valenti C; Servicio de Medicina Interna, Hospital de Navarra, Mendillorri,; Navarra.
[Determination of anti-HIV using an automated ELFA method (enzyme linked immunofluorescent assay)(VIDAS HIV 1/2 new) (letter)]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):439. Unique Identifier : AIDSLINE MED/98064478; Jaqueti J; Bua MC; Preciado B
[Oral and esophageal aphthous ulcers in a child with AIDS successfully treated with colony stimulating factors (GM-CSF) letter)]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):439-40. Unique Identifier : AIDSLINE MED/98064479; Pocheville I; Gutierrez C; Gonzalez J
[Streptococcal necrotising fasciitis in a hemophilic patient with the human immunodeficiency virus infection (letter)]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):443-4. Unique Identifier : AIDSLINE MED/98064483; Galan F; Barrero F; Marin P; Martorell J; Capote FJ
[The clinical and evolutional characteristics of visceral leishmaniasis in patients with HIV infection]: An Med Interna. 1997 Oct;14(10):506-10. Unique Identifier : AIDSLINE MED/98057991; Delgado Fernandez M; Garcia Ordonez MA; Martos Perez F; Reguera Iglesias JM; Jimenez Onate F; Colmenero Castillo JD; Departamento de Medicina Interna, Hospital Regional Carlos Haya,; Malaga.; OBJECTIVE: To analyze the clinical features, yield of the diagnostic techniques, and therapeutic response of HIV-associated visceral leishmaniasis (VL), and compare the initial episodes to the relapses. METHODS: Forty-one episodes of leishmaniasis visceral, diagnosed in 31 HIV-positive patients between 1st February 19
[HIV/AIDS in primary care: the opinions and needs of Galician health professionals]: Aten Primaria. 1997 Oct 15;20(6):319-23. Unique Identifier : AIDSLINE MED/98058095; Figueiras A; Lopez-Alvarez XL; Monteagudo-Romero J; Taboada-Rodriguez XA; Area de Medicina Preventiva e Saude Publica, Universidade de Santiago; de Compostela.; OBJECTIVE: To find the views and identify the needs of Galician primary health care (PHC) professionals concerning HIV/AIDS. DESIGN: An observational cross-sectional study. SETTING: Autonomous Community of Galicia. PARTICIPANTS: Primary care professionals from medicine (N = 1,523, n = 510), nursing (N = n = 220) and p
[Study of HIV isolation in sperm (letter; comment)]: Contracept Fertil Sex. 1997 Oct;25(10):802. Unique Identifier : AIDSLINE MED/98064445; Greacen T; Brechard N
[Nursing and AIDS: knowledge and paradigm]: Rev Lat Am Enfermagem. 1997 Jan;5(1):65-73. Unique Identifier : AIDSLINE MED/97391744; Xavier I de M; Leite JL; Braga GM; Nunes PH; Escola de Enfermagem Alfredo Pinto da Universidade do Rio de Janeiro.; This study is a part of a research that comments the relation between Nursing Knowledge and AIDS. The actual period of time is treated like a period of transition between the modern science and one new paradigm. This is called post-modern science. It brings the dynamics of AIDS in Braz
[An unusual case of tuberculosis in an immunocompetent patient]: Arch Bronconeumol. 1997 Oct;33(9):475-7. Unique Identifier : AIDSLINE MED/98057589; Roig Figueroa V; Perez Lucena E; Rodriguez Vidigal F; Ledesma Jurado V; Aguilar Escobar J; Ramirez Gurruchaga P; Unidad de Neumologia, Complejo Hospitalario Llerena-Zafra, Badajoz.; Gastric tuberculosis is a rare entity that often coincides with pulmonary involvement at the time of diagnosis. Many cases reported in developed countries are in immunodepressed patients, particularly those with HIV infection. We report the case of a 43-year-old man who presented with weight loss of 14 kg, persistent
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.: Structure. 1997 Oct 15;5(10):1361-72. Unique Identifier : AIDSLINE MED/98035457; Arold S; Franken P; Strub MP; Hoh F; Benichou S; Benarous R; Dumas C; Centre de Biochimie Structurale, UMR C9955 CNRS, U414 INSERM,; Universite Montpellier I, Faculte de Pharmacie, France.; BACKGROUND: Human immunodeficiency virus (HIV) Nef protein accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of
Polyarthritis with cutaneous mucinosis and intrasynovial mucin deposits.: Rev Rhum Engl Ed. 1997 Oct;64(10):582-5. Unique Identifier : AIDSLINE MED/98046806; Chazerain P; Palazzo E; Bouscarat F; Grossin M; Picard C; Meyer O; Belaich S; Kahn MF; Rheumatology Department (1), Bichat Teaching Hospital, Paris, France.; We report the first case of cutaneous and articular mucinosis with presence of mucin deposits within the synovium in an HIV-positive patients. Presentation was asymmetric polyarthritis, and subcutaneous nodules developed two months later. Treatment was with hydroxychloroquine. The outcome of both the skin and joint le
Number of new AIDS cases in U.S. declines for first time since AIDS/HIV epidemic began [news]: Psychiatr Serv. 1997 Nov;48(11):1481. Unique Identifier : AIDSLINE MED/98016801
HIV risk behaviors [letter]: Psychiatr Serv. 1997 Dec;48(12):1592-3. Unique Identifier : AIDSLINE MED/98069347; McKinnon K
Trimethoprim/sulfamethoxazole incremental dose regimen in human immunodeficiency virus-infected persons.: Ann Allergy Asthma Immunol. 1997 Nov;79(5):409-14. Unique Identifier : AIDSLINE MED/98059105; Rich JD; Sullivan T; Greineder D; Kazanjian PH; Department of Medicine, University of Michigan Medical Ctr, Ann Arbor; 48109-0378, USA.; BACKGROUND: The mechanism of tolerance to incremental doses of trimethoprim-sulfamethoxazole given to human immunodeficiency virus-infected persons who have had a prior intolerance to this agent has not been studied. OBJECTIVE: We prospectively evaluated a regimen of incremental doses of oral trimethoprim-sulfamethoxa
Immunomagnetic selection of purified monocyte and lymphocyte populations from peripheral blood mononuclear cells following cryopreservation.: Clin Diagn Lab Immunol. 1997 Nov;4(6):653-8. Unique Identifier : AIDSLINE MED/98043940; Sleasman JW; Leon BH; Aleixo LF; Rojas M; Goodenow MM; Department of Pediatrics, University of Florida College of Medicine,; Gainesville 32610, USA.; Cryopreservation is a method commonly used to store human blood samples. We sought to determine if cryopreserved peripheral blood mononuclear cells (PBMC) could be separated effectively into distinct populations by using monoclonal antibodies and immunomagnetic microspheres. PBMC obtained from healthy blood donors and
Development of an enzyme-linked immunosorbent assay for measurement of serum-associated ALX40-4C.: Clin Diagn Lab Immunol. 1997 Nov;4(6):671-5. Unique Identifier : AIDSLINE MED/98043943; Payette PJ; Cormier M; Dabek B; Yungblut P; Presseault S; Climie S; Sahai J; Cameron WD; Filion LG; Department of Microbiology and Immunology, University of Ottawa,; Faculty of Medicine, Ontario, Canada.; ALX40-4C is an antiretrovirus agent that has been found to have some inhibitory properties against human immunodeficiency virus HIV) replication in vitro. The compound was designed as a competitor of the HIV Tat protein for TAR binding. In addition to its anti-HIV properties, it has demonstrated the ability to inhibit
CD4+-T-cell counts, spontaneous apoptosis, and Fas expression in peripheral blood mononuclear cells obtained from human immunodeficiency virus type 1-infected subjects.: Clin Diagn Lab Immunol. 1997 Nov;4(6):736-41. Unique Identifier : AIDSLINE MED/98043956; Patki AH; Georges DL; Lederman MM; ACTG Immunology Advanced Technology Laboratory and the Center for AIDS; Research, Case Western Reserve University School of Medicine,; Cleveland, Ohio 44106, USA.; We examined the relationships among CD4+-T-cell counts, spontaneous apoptosis, and Fas expression among peripheral blood mononuclear cells obtained from human immunodeficiency virus type 1 (HIV-1)-infected patients. After 2 days of incubation, propidium iodide DNA staining and flow cytometry revealed that peripheral b
Timing of lymphocyte activation in neonates infected with human immunodeficiency virus.: Clin Diagn Lab Immunol. 1997 Nov;4(6):742-7. Unique Identifier : AIDSLINE MED/98043957; Gallagher K; Gorre M; Harawa N; Dillon M; Wafer D; Stiehm ER; Bryson Y; Song D; Dickover R; Plaeger S; Department of Pediatrics, UCLA School of Medicine, Los Angeles,; California 90095-1752, USA.; Human immunodeficiency virus (HIV) infection in children is associated with qualitative and quantitative changes in the peripheral lymphocyte surface phenotype beyond the normal maturational changes. Neonates, however, have been reported to have a delayed immune response to HIV compared to HIV-infected adults. We pros
Clinical field site evaluation of the FACSCount for absolute CD3+, CD3+ CD4+, and CD3+ CD8+ cell count determinations in Thailand.: Clin Diagn Lab Immunol. 1997 Nov;4(6):783-6. Unique Identifier : AIDSLINE MED/98043964; Young NL; Ponglertnapakorn P; Shaffer N; Srisak K; Chaowanachan T; On-Thern V; Kittinunvorakoon C; Bunwattanakul A; Suksaweang S; Pobkeeree V; Punnotok J; Mastro TD; HIV/AIDS Collaboration and Department of Communicable Disease Control,; Central Chest Hospital, Nonthaburi, Thailand. NLY0@cdc.gov; The FACSCount flow cytometer absolute CD3+, CD3+ CD4+, and CD3+ CD8+ cell counts measured at a field site hospital laboratory in Thailand were compared to FACScan absolute counts obtained at a nearby research laboratory. Correlation coefficients for 208 samples were > or = 0.95.
High prevalence of antibodies to Mycoplasma penetrans in human immunodeficiency virus-seronegative and -seropositive populations in Brazzaville, Congo.: Clin Diagn Lab Immunol. 1997 Nov;4(6):787-8. Unique Identifier : AIDSLINE MED/98043965; Tuppin P; Delamare O; Launay V; Gueguen M; Samba MC; Pambou L; Montagnier L; Grau O; Unites d'Epidemiologie des Virus Oncogenes, Departement SIDA et; Retrovirus, Institut Pasteur, Paris, France.; In industrialized countries, the prevalence of antibodies to Mycoplasma penetrans is higher among human immunodeficiency virus HIV)-seropositive homosexuals than other HIV-seropositive and HIV-seronegative groups. In an African heterosexual population, we found a higher prevalence of M. penetrans antibodies in HIV-ser
Altered expression of Fc gammaRIII (CD16) on polymorphonuclear neutrophils from individuals with human immunodeficiency virus type 1 disease and pulmonary tuberculosis.: Clin Diagn Lab Immunol. 1997 Nov;4(6):789-91. Unique Identifier : AIDSLINE MED/98043966; Meddows-Taylor S; Martin DJ; Tiemessen CT; National Institute for Virology, and Department of Virology,; University of the Witwatersrand, Johannesburg, South Africa.; Fc gammaRIII (CD16) expression on the surfaces of polymorphonuclear neutrophils was significantly reduced in human immunodeficiency virus type 1-seropositive patients with pulmonary tuberculosis compared to that in individuals with either disease alone or in healthy blood donors. This downregulation of Fc gammaRIII ma
Supreme Court of Delaware rules in favor of HIV-positive dentist [news]: J Can Dent Assoc. 1997 Nov;63(10):733. Unique Identifier : AIDSLINE MED/98064562
Tc-99m LL-2 Fab' monoclonal antibody imaging in acquired immune deficiency syndrome-related lymphoma.: Cancer. 1997 Dec 15;80(12 Suppl):2469-77. Unique Identifier : AIDSLINE MED/98068532; Kramer EL; Volm M; Donahue B; Wasserheit C; Chapnick J; Sanger J; Koslow M; Department of Radiology, NYU Medical Center/Bellevue Hospital Center,; New York 10016, USA.; BACKGROUND: Both systemic and primary central nervous system CNS) non-Hodgkin s lymphomas (NHL) occur in people with acquired immune deficiency syndrome (AIDS). The radiographic manifestations may be similar to other neoplasms and opportunistic infections that are also found frequently in AIDS. Furthermore, these dise
Sister chromatid exchange analysis of human cells carrying retroviral DNA.: Cancer Genet Cytogenet. 1998 Jan 1;100(1):72-6. Unique Identifier : AIDSLINE MED/98069683; Koshikawa N; Mochizuki S; Nakano M; Maruyama K; Division of Pathology, Chiba Cancer Center Research Institute, Japan.; Chromosomal abnormalities have been seen in human cells following infection with human T lymphotropic virus type I (HTLV-I). Effects on sister chromatid exchange (SCE) in cells carrying HTLV-I related DNA were examined by treatment with N-methyl-N -nitro-N-nitrosoguanidine (MNNG). Peripheral blood specimens were obtai
TCL1 is overexpressed in patients affected by adult T-cell leukemias.: Cancer Res. 1997 Dec 15;57(24):5452-6. Unique Identifier : AIDSLINE MED/98069837; Narducci MG; Stoppacciaro A; Imada K; Uchiyama T; Virgilio L; Lazzeri C; Croce CM; Russo G; Laboratory of Vascular Pathology, Roma, Italy.; Among mature postthymic T-cell leukemias, adult T-cell leukemia ATL) has characteristic clinicopathological entities. The association with the human T-cell leukemia/lymphotropic virus type I is one of the distinctive etiopathogenetic features of this disease. However, unlike other acute transforming retroviruses, the
Viral activity in early HIV disease.: Curr Opin Hematol. 1994 Jan;1(1):19-23. Unique Identifier : AIDSLINE MED/98038593; Freedman AR; Scadden DT; Division of Hematology/Oncology, New England Deaconess Hospital,; Boston, MA 02215, USA.; The commonly accepted paradigm for the natural history of HIV disease has been an acute burst of virus replication followed by years of viral quiescence. A terminal phase of virus activity is accompanied by gradual immunologic failure. Recent studies of the tissue localization of HIV and developments in virus quantita
Penetration, retention, intracellular localization, and antimicrobial activity of antibiotics within phagocytes.: Curr Opin Hematol. 1994 Jan;1(1):85-91. Unique Identifier : AIDSLINE MED/98038602; Silverstein SC; Kabbash C; Columbia University College of Physicians and Surgeons, New York, New; York, USA.; The deficiency in cell-mediated immunity that is the hallmark of AIDS has led to a resurgence of infections with tubercle bacilli and other intracellular pathogens, and to renewed attention to the mechanisms by which antibiotics penetrate and are retained within phagocytic leukocytes. We review here recent studies of
Thrombocytopenia in HIV infection.: Curr Opin Hematol. 1994 Sep;1(5):369-72. Unique Identifier : AIDSLINE MED/98038645; Louache F; Vainchenker W; Institute Gustave Roussy, Villejuif, France.; Thrombocytopenia commonly occurs in individuals with HIV disease. However, profound thrombocytopenia, occurring in only 1.5% of cases, is relatively rare. The mechanisms of thrombocytopenia appear to be multifactorial: profound thrombocytopenia in HIV disease is related to an immune destruction either by antiplatelet
Transfusion and HIV.: Curr Opin Hematol. 1994 Nov;1(6):438-42. Unique Identifier : AIDSLINE MED/98038658; Busch MP; Irwin Memorial Blood Centers, San Francisco, California, USA.; Over a decade has passed since the first cases of AIDS were reported in hemophiliacs and transfusion recipients. Studies published over the past year offer an increasingly clear understanding of the extent of the early transfusion-associated AIDS epidemic, and of the effectiveness of progressive donor screening measur
Circulating levels of IL-10 are critically related to growth and rejection patterns of murine mastocytoma cells.: Cell Immunol. 1997 Nov 1;181(2):109-19. Unique Identifier : AIDSLINE MED/98063334; Grohmann U; Silla S; Belladonna ML; Bianchi R; Orabona C; Puccetti P; Fioretti MC; Department of Experimental Medicine, University of Perugia, Italy.; pharmpg@tin.it; Previously tumorigenic P815 tumor cells are rejected by histocompatible mice after transfection with a mutated retroviral gene, and the host is made resistant to subsequent challenge with tumorigenic (control) cells transfected with the nonmutated sequence. To functionally characterize the class I-restricted response
Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy.: Immunotechnology. 1995 May;1(1):1-19. Unique Identifier : AIDSLINE MED/98040660; Marasco WA; Division of Human Retrovirology, Dana-Farber Cancer Institute, Harvard; Medical School, Boston, MA 02115, USA. WayneMarasco@dfci.harvard.edu
Human monoclonal Fab fragments specific for viral antigens from combinatorial IgA libraries.: Immunotechnology. 1995 May;1(1):21-8. Unique Identifier : AIDSLINE MED/98040661; Moreno de Alboran I; Martinez-alonso C; Barbas CF 3rd; Burton DR; Ditzel HJ; Department of Immunology, Scripps Research Institute, La Jolla, CA; 92037, USA.; BACKGROUND: IgA constitutes the first line of immune defense, interacting with a variety of environmental antigens. Following infection with respiratory syncytial virus (RSV) individuals frequently exhibit elevated serum IgA titers specific for the virus. Previously combinatorial IgG libraries have successfully been u
Escherichia coli expression of a bifunctional Fab-peptide epitope reagent for the rapid diagnosis of HIV-1 and HIV-2.: Immunotechnology. 1995 Dec;1(3-4):197-209. Unique Identifier : AIDSLINE MED/98040679; Dolezal O; Coia G; Guthrie RE; Lilley GG; Hudson PJ; CSIRO, Division of Biomolecular Engineering, Parkville, Victoria,; Australia.; BACKGROUND: The current format of a rapid whole-blood agglutination assay for HIV relies on a bifunctional molecule which comprises a 1C3 Fab fragment, with specificity for the human red blood cell surface marker (glycophorin A), chemically conjugated to a synthetic peptide that corresponds to a single immunodominant
Induction of mucosal anti-HIV antibodies by facilitated transfection of airway epithelium with lipospermine/DNA complexes.: Immunotechnology. 1995 Dec;1(3-4):211-9. Unique Identifier : AIDSLINE MED/98040680; Mitchell WM; Rosenbloom ST; Gabriel J; Department of Pathology, Vanderbilt University, Nashville, TN 37232,; USA.; BACKGROUND: Expression of microbial protein sequences in eukaryotic cells transfected by transcriptional/translational permissive cDNA constructs can induce systemic humoral and cellular responses in vivo. Two methods of in vivo transfection have been described to date. One method uses large quantities of naked DNA in
Communicable diseases surveillance.: Commun Dis Intell. 1997 Oct 30;21(21):323-31. Unique Identifier : AIDSLINE MED/98043019
Students get gritty introduction to reality of HIV/AIDS [news]: CMAJ. 1997 Dec 1;157(11):1503. Unique Identifier : AIDSLINE MED/98062952; Kent H
On the definition and the construction of pockets in macromolecules.: Pac Symp Biocomput. 1996;:272-87. Unique Identifier : AIDSLINE MED/98051677; Edelsbrunner H; Facello M; Liang J; Department of Computer Science, University of Illinois at; Urbana-Champaign, USA.; The shape of a protein is important for its functions. This includes the location and size of identifiable regions in its complement space. We formally define pockets as regions in the complement with limited accessibility from the outside. Pockets can be efficiently constructed by an algorithm based on alpha complexe
Determination of proton transfer rate constants using Ab initio, molecular dynamics and density matrix evolution calculations.: Pac Symp Biocomput. 1996;:624-37. Unique Identifier : AIDSLINE MED/98051702; van der Spoel D; Berendsen HJ; BIOSON Research Institute, Department of Biophysical Chemistry,; University of Groningen, The Netherlands.; In this work we give an overview of the methodologies required to compute the rate of proton transfer in hydrogen bonded systems in solution. Using ab initio or density functional methods we determine proton potentials of a truncated system as a function of proton-donor proton-acceptor distance as well as nonbonding p
Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic analysis of hydrophobic mutations.: Pac Symp Biocomput. 1996;:638-52. Unique Identifier : AIDSLINE MED/98051703; Verkhivker GM; Agouron Pharmaceuticals, Inc., San Diego, CA 92121-1121, USA.; Empirical free energy calculations of HIV-1 protease crystallographic complexes based on the developed knowledge-based ligand-protein interaction potentials have enabled a detailed thermodynamic analysis. Binding free energies are estimated within an empirical model that postulates that hydrophobic effect, mean field
Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin.: Chem Biol Interact. 1997 Nov 6;107(1-2):17-30. Unique Identifier : AIDSLINE MED/98066651; Li AP; Reith MK; Rasmussen A; Gorski JC; Hall SD; Xu L; Kaminski DL; Cheng LK; In Vitro Technologies, Baltimore, MD 21227, USA.; In our laboratory, primary human hepatocytes are being investigated as an in vitro experimental system for the evaluation of pharmacokinetic drug-drug interactions. Our study here represents the first reported study that directly compares the cytochrome P450 isozyme 3A (CYP3A) induction potential of three antimicrobia
Gender and ethnic differences in survival in a cohort of HIV positive clients.: Ethn Health. 1996 Mar;1(1):77-85. Unique Identifier : AIDSLINE MED/98051732; Bright PE; Arnett DK; Blair C; Bayona M; Department of Epidemiology and Biostatistics, College of Public; Health, University of South Florida, Tampa 33612-3805, USA.; OBJECTIVES: The purpose of this study was to examine gender and ethnic differences in survival of persons receiving treatment for HIV infection to determine if differences existed, and if they did, to assess the possibility of explaining these differences by examining other factors, such as age, disease severity when
Race/ethnicity misclassification of persons reported with AIDS. The AIDS Mortality Project Group and The Supplement to HIV/AIDS Surveillance Project Group.: Ethn Health. 1996 Mar;1(1):87-94. Unique Identifier : AIDSLINE MED/98051733; Kelly JJ; Chu SY; Diaz T; Leary LS; Buehler JW; Surveillance Branch, National Center for Infectious Diseases, Centers; for Disease Control and Prevention, Atlanta, GA 30333, USA.; OBJECTIVES: To examine differences in race/ethnicity classifications of persons with AIDS among three reporting sources and to estimate the effect of these differences on calculated AIDS rates. METHODS: We reviewed case reports from the national AIDS surveillance database, interview (self-reported) data from 11 state/
Longitudinal effects of an HIV testing and counseling programme for low-income Latina women.: Ethn Health. 1997 Mar-Jun;2(1-2):89-103. Unique Identifier : AIDSLINE MED/98051774; Flaskerud JH; Nyamathi AM; Uman GC; University of California, Los Angeles School of Nursing 90095-1702,; USA.; OBJECTIVES: The purpose of this study was to assess the effects of an HIV antibody testing, counseling and education programme on the knowledge and practices of low-income Los Angeles Latina women. METHODS: The study design was prospective and longitudinal involving pre-test, post-test and retest measures over a 2-yea
Diarrhea and human immunodeficiency virus: a possible synergy for clinical practice [see comments]: J Altern Complement Med. 1997 Summer;3(2):163-8. Unique Identifier : AIDSLINE MED/98051890; Anastasi JK; Dawes NC; Li YM; Center for AIDS Research, Columbia University School of Nursing, New; York, NY, USA.; Sixty percent of patients with human immunodeficiency virus (HIV) in the United States and 90% throughout the world will have diarrhea at some point in their illness. This article provides an introductory exploration and discussion of Western and Eastern perspectives of chronic diarrhe
HIV-related diarrhea: urgent need for a reasoned holistic response [editorial; comment]: J Altern Complement Med. 1997 Summer;3(2):169-72. Unique Identifier : AIDSLINE MED/98051891; Carter GM
Allergen-induced airway reactions in atopic asthmatics correlate with allergen-specific IL-5 response by BAL cells.: Respirology. 1997 Mar;2(1):45-55. Unique Identifier : AIDSLINE MED/98059588; Tang C; Rolland JM; Ward C; Quan B; Walters EH; Department of Respiratory Medicine, Alfred Hospital, Prahran,; Victoria, Australia.; Allergen-specific cytokine responses in the airways are thought to play a critical role in the pathogenesis of atopic asthma. This study examined whether there is a quantitative difference in bronchoalveolar lavage (BAL) cell allergen-induced IL-5 production between atopic subjects with and without asthma which may re
Tuberculosis and HIV infection: global perspectives.: Respirology. 1997 Sep;2(3):209-13. Unique Identifier : AIDSLINE MED/98063450; Murray JF; Division of Pulmonary and Critical Care Medicine, San Francisco; General Hospital Medical Center, University of California, USA.; This paper reviews the epidemiological and clinical aspects of the interaction between Mycobacterium tuberculosis and HIV infection. The incidence of HIV-associated tuberculosis is increasing worldwide and is expected to increase further, especially in Africa and parts of Asia. HIV infection appears to increase the li
Professional nurses knowledge and understanding of AIDS/HIV infection.: Curationis. 1997 Jul;20(2):43-6. Unique Identifier : AIDSLINE MED/98079637; Chamane NJ; Kortenbout W; Department of Nursing, University of Natal.; This study examined professional nurses knowledge and understanding of AIDS/HIV infection. The sample was formed by 53 professional nurses; 27 being those that have done the AIDS counselling course (trained counsellors) and 26 who have not done the course. This sample was randomly chosen from a population of 192 prof
Humoral immune response within the lung in HIV-1 infection.: Clin Exp Immunol. 1997 Dec;110(3):341-8. Unique Identifier : AIDSLINE MED/98072292; Moja P; Jalil A; Quesnel A; Perol M; Cotte L; Livrozet JM; Boibieux A; Chamson A; Vergnon JM; Lucht F; Tran R; Pozzetto B; Genin C; Groupe Immunite des Muqueuses et Agents Pathogenes, University of; Saint-Etienne, France.; In order to study the humoral immune defences in the respiratory tract during HIV-1 infection, we measured the levels, local productions and anti-HIV and antibacterial activities of IgG and IgA in the bronchoalveolar lavage fluid (BALF) and serum of 61 adult patients with severe HIV infection and of 56 HIV- controls.
HLA-dependent peripheral T cell receptor (TCR) repertoire formation and its modification by rheumatoid arthritis (RA).: Clin Exp Immunol. 1997 Dec;110(3):428-33. Unique Identifier : AIDSLINE MED/98072305; Mizushima N; Kohsaka H; Nanki T; Ollier WE; Carson DA; Miyasaka N; First Department of Internal Medicine, School of Medicine, Tokyo; Medical and Dental University, Japan.; Our previous studies have disclosed that the peripheral T cell receptor beta (TCRB) gene repertoires of RA monozygotic twins were similar. This suggested that the TCRBV repertoire is controlled primarily by genetic factors. Here, we examine how the combination of HLA and presence of RA influence the peripheral TCRB re
Detection of Pneumocystis carinii by DNA amplification in human immunodeficiency virus-positive patients.: Diagn Microbiol Infect Dis. 1997 Oct;29(2):61-5. Unique Identifier : AIDSLINE MED/98034441; Savoia D; Millesimo M; Cassetta I; Forno B; Caramello P; Department of Clinical and Biological Sciences, University of Torino,; Italy.; The opportunistic pathogen Pneumocystis carinii (PC) is a frequent cause of a life-threatening pneumonia in human immunodeficiency virus (HIV)-infected individuals and in other immunocompromised hosts. Specimens obtained from 128 bronchoalveolar lavage (BAL) fluid samples from 123 HIV-positive patients with pulmonary
[Advance in the gene therapy of HIV infections]: Chung Hua Nei Ko Tsa Chih. 1996 Mar;35(3):203-5. Unique Identifier : AIDSLINE MED/98048907; Cheng J; Shi C
[Experimental studies on effects of zinc and germanium on immune function and anti-oxidation in mice]: Chung Hua Yu Fang I Hsueh Tsa Chih. 1996 Jul;30(4):221-4. Unique Identifier : AIDSLINE MED/98050281; Xin H; Han T; Gong S; General Hospital, Shenyang Command PLA.; Zinc and germanium concentrations in serum, liver and muscle of mice, T-lymphocyte subgroup proportion, serum superoxide dismutase (SOD) activity and malonodialdehyde (MDA) were determined to study whether there exist synergism or antagonism between zinc and germanium. Results showed there existed, to certain extent, e
Prediction of effect of interferon on chronic hepatitis C.: Dig Dis Sci. 1997 Nov;42(11):2270-6. Unique Identifier : AIDSLINE MED/98061052; Takagi H; Takehara K; Shimoda R; Kakizaki S; Takayama H; Abe T; Yamada T; Hashimoto Y; Saitoh S; Matsumoto T; Kojima A; Takezawa J; Yuasa K; Moriguchi M; Sekiguchi T; Nagamine T; Mori M; First Department of Internal Medicine, Gunma University School of; Medicine, Japan.; Clinical, pathological, and virological analysis including hypervariable region-1 of hepatitis C virus (HCV) was performed to predict the effect of interferon (IFN) on 41 patients with chronic hepatitis type C. The low virus load, low frequency of the mutation in the hypervariable region-1 as the change of amino acid e
[Cystic form of Pneumocystis carinii pneumonia]: Dtsch Med Wochenschr. 1997 Nov 21;122(47):1441-6. Unique Identifier : AIDSLINE MED/98076789; Fatkenheuer G; Franzen C; Hartmann P; Wassermann K; Schrappe M; Dolken W; Diehl V; Salzberger B; Klinik I fur Innere Medizin, Universitat zu Koln.; G.Faetkenheuer@uni-koeln.de; BASIC PROBLEM AND OBJECTIVE: In rare instances Pneumocystis carinii pneumonia (PCP) can occur in a cystic form, characterized by an acute course. The correct diagnosis is often missed. An analysis of a large cohort of patients with PCP was undertaken to determine the incidence and clinical manifestations of this form e
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.: EMBO J. 1997 Nov 3;16(21):6535-47. Unique Identifier : AIDSLINE MED/98063000; Izaurralde E; Kutay U; von Kobbe C; Mattaj IW; Gorlich D; University of Geneva, Department of Molecular Biology, Switzerland.; The GTPase Ran is essential for nuclear import of proteins with a classical nuclear localization signal (NLS). Ran s nucleotide-bound state is determined by the chromatin-bound exchange factor RCC1 generating RanGTP in the nucleus and the cytoplasmic GTPase activating protein RanGAP1 depleting RanGTP from the cytoplase
Functional differences between the human LINE retrotransposon and retroviral reverse transcriptases for in vivo mRNA reverse transcription.: EMBO J. 1997 Nov 3;16(21):6590-602. Unique Identifier : AIDSLINE MED/98063005; Dhellin O; Maestre J; Heidmann T; Unite de Physicochimie et Pharmacologie des Macromolecules; Biologiques, CNRS URA147, Institute Gustave Roussy, Villejuif, France.; We have analysed the reverse transcriptase (RT) activity of the human LINE retrotransposon and that of two retroviruses, using an in vivo assay within mammalian (murine and human) cells. The assay relies on transfection of the cells with expression vectors for the RT of the corresponding elements and PCR analysis of te
Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin.: EMBO J. 1997 Nov 17;16(22):6636-45. Unique Identifier : AIDSLINE MED/98031891; Martoglio B; Graf R; Dobberstein B; Zentrum fur Molekulare Biologie der Universitat Heidelberg ZMBH),; Postfach 106249, 69052 Heidelberg, Germany.; Secretory proteins and most membrane proteins are synthesized with a signal sequence that is usually cleaved from the nascent polypeptide during transport into the lumen of the endoplasmic reticulum. Using site-specific photo-crosslinking we have followed the fate of the signal sequence of preprolactin in a cell-free e
Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.: EMBO J. 1997 Nov 17;16(22):6849-59. Unique Identifier : AIDSLINE MED/98031911; Jenkins TM; Esposito D; Engelman A; Craigie R; Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892-0560,; USA.; Analysis of the crystal structure of HIV-1 integrase reveals a cluster of lysine residues near the active site. Using site-directed mutagenesis and photo-crosslinking we find that Lys156 and Lys159 are critical for the functional interaction of integrase with viral DNA. Mutation of Lys156 or Lys159 to glutamate led toe
Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.: Eur J Immunol. 1997 Nov;27(11):2805-11. Unique Identifier : AIDSLINE MED/98056785; Borgatti P; Zauli G; Colamussi ML; Gibellini D; Previati M; Cantley LL; Capitani S; Institute of Human Anatomy, University of Ferrara, Italy.; The biological basis for the pleiotropic activity of extracellular human immunodeficiency virus (HIV)-1 Tat protein on lymphoid T cell survival is not well understood. We have here demonstrated that the addition in culture of 0.1-10 nM Tat protein to 36-h serum-starved lymphoblastoid Jurkat T cells rapidly stimulates e
The central nervous system environment controls effector CD4+ T cell cytokine profile in experimental allergic encephalomyelitis.: Eur J Immunol. 1997 Nov;27(11):2840-7. Unique Identifier : AIDSLINE MED/98056790; Krakowski ML; Owens T; Department of Neurology and Neurosurgery, Montreal Neurological; Institute, Canada. michellek@scripps.edu; In experimental allergic encephalomyelitis (EAE), CD4+ T cells infiltrate the central nervous system (CNS). We derived CD4+ T cell lines from SJL/J mice that were specific for encephalitogenic myelin basic protein (MBP) peptides and produced both Th1 and Th2 cytokines. These lines transferred EAE to naive mice. Peptide
Thymic T cell export is not influenced by the peripheral T cell pool.: Eur J Immunol. 1997 Nov;27(11):2986-93. Unique Identifier : AIDSLINE MED/98056810; Gabor MJ; Scollay R; Godfrey DI; Centenary Institute of Cancer Medicine and Cell Biology, Sydney,; Australia.; The peripheral T cell pool is maintained both by export of naive T cells from the thymus and by post-thymic expansion of activated/memory T cells. However, it is not known whether the thymus can alter its output following peripheral T cell depletion. Using intrathymic injection of fluorescein isothiocyanate to detect e
Nef protein of HIV-1 induces apoptotic cytolysis of murine lymphoid cells independently of CD95 (Fas) and its suppression by serine/threonine protein kinase inhibitors.: FEBS Lett. 1997 Nov 3;417(1):61-4. Unique Identifier : AIDSLINE MED/98055453; Okada H; Takei R; Tashiro M; Department of Virology 1, National Institute of Infectious Diseases,; Tokyo, Japan.; The Nef protein of HIV-1 is suggested to play a role in depletion of uninfected CD4+ T cells leading to the development of AIDS. The recombinant soluble Nef protein was shown to bind to cell surfaces of various murine lymphoid cell lines, including T and B lymphocytes, mastocytoma cells and macrophages. Cross-linking e
Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load.: Gastroenterology. 1997 Dec;113(6):1848-57. Unique Identifier : AIDSLINE MED/98056706; Mohammadi M; Nedrud J; Redline R; Lycke N; Czinn SJ; Institute of Pathology, Case Western Reserve University, Cleveland,; Ohio, USA.; BACKGROUND & AIMS: Previous findings suggest that TH1 cellular immune responses contribute to Helicobacter-associated gastritis. To further investigate this issue, interleukin 4 gene targeted mice were infected with Helicobacter felis, and a series of adoptive transfer experiments was performed to evaluate the role
Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.: Gen Pharmacol. 1997 Oct;29(4):497-511. Unique Identifier : AIDSLINE MED/98013548; Witvrouw M; De Clercq E; Rega institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; The inhibitory effects of polyanionic substances on the replication of herpes simplex virus (HSV) and other viruses were reported almost four decades ago. However, these observations did not generate much interest, because the antiviral action of the compounds was considered to be largely nonspecific. Shortly after th
Clinical, histological, and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels.: Hepatology. 1997 Dec;26(6):1393-8. Unique Identifier : AIDSLINE MED/98058585; Puoti C; Magrini A; Stati T; Rigato P; Montagnese F; Rossi P; Aldegheri L; Resta S; Liver Unit, E. De Santis Genzano General Hospital, Rome, Italy.; This study was aimed to evaluate demographic, clinical, histological, and virological characteristics of 46 hepatitis C virus (HCV) carriers with persistently normal alanine transaminase (ALT) levels and to compare the results with those obtained in a group of 52 HCV-RNA-positive patients with elevated ALT levels. Sub
Prediction of response during interferon alfa 2b therapy in chronic hepatitis C patients using viral and biochemical characteristics: a comparison.: Hepatology. 1997 Dec;26(6):1640-5. Unique Identifier : AIDSLINE MED/98058619; Tong MJ; Blatt LM; McHutchison JG; Co RL; Conrad A; Liver Center, Huntington Memorial Hospital, Pasadena, CA 91105, USA.; Patients with chronic hepatitis C (n = 103) were treated for 24 weeks with interferon alfa 2b and followed up for 24 weeks after cessation of therapy (week 48). When hepatitis C virus (HCV) RNA at week 48 was used to assess interferon response, 15 (14.6%) were virological complete responders, and all have remained HCV
Hepatitis C: viral kinetics [letter]: Hepatology. 1997 Dec;26(6):1691-3. Unique Identifier : AIDSLINE MED/98058632; Bekkering FC; Brouwer JT; Schalm SW; Elewaut A
HIV infection: legal aspects [editorial]: Indian J Pathol Microbiol. 1997 Jul;40(3):301-2. Unique Identifier : AIDSLINE MED/98015500; Talib VH; Verma SK; Dhupia JS; Khurana SK; Thergaonkar A
Characterization of mycobacterial species in clinically diagnosed cases of pulmonary tuberculosis and their HIV status.: Indian J Pathol Microbiol. 1997 Jul;40(3):365-7. Unique Identifier : AIDSLINE MED/98015512; Patwardhan NS; Bansal MP; Pradhan J; Department of Microbiology, Government Medical College, Aurangabad.; A total of 75 clinically diagnosed and radiologically evident cases suggestive of pulmonary tuberculosis were selected for study. Sputum sample of each patient was screened for AFB by Ziehl Neelsen staining and culture. On examination 20 smears were found positive for AFB and 55 smears were negative by concentration m
A study on interrelationship of 60 HIV positive cases with coexistent oral candidosis and tuberculosis.: Indian J Pathol Microbiol. 1997 Jul;40(3):377-82. Unique Identifier : AIDSLINE MED/98015515; Talib SH; Singh J; Department of Medicine, Government Medical College, Aurangabad.; Sixty HIV seropositive cases studied of inter-relationship of coexistent infections with tuberculosis and oral candidosis. Presence of oral candidosis either symptomatic/asymptomatic as revealed on microbiological studies have been recorded and the significance discussed. Presence of oral candidosis apparent of nonapp
Multiple myeloma complicating HIV-infection. A case report.: Indian J Pathol Microbiol. 1997 Jul;40(3):413-6. Unique Identifier : AIDSLINE MED/98015524; Talib SH; Singh J; Ranga S; Talib VH; Department of Medicine, Government Medical College, Aurangabad.; A case of multiple myeloma associated with HIV disease and hepatosplenomegaly presented to us as pyrexia of unknown origin, is reported. Because of paucity of such cases in the literature, the case is dealt in detail and the literature reviewed briefly.
Haematological manifestation of HIV infection.: Indian J Pathol Microbiol. 1997 Jul;40(3):417-31. Unique Identifier : AIDSLINE MED/98015525; Ranga S; Prakash I; Khurana SK; Talib VH; Department of Laboratory Medicine, Safdarjang Hospital, New Delhi.
Problems in interpretation of results of HIV tests [letter]: Indian J Pathol Microbiol. 1997 Jul;40(3):434. Unique Identifier : AIDSLINE MED/98015527; Kapoor A; Lahiri M; Basu S
Protection against Pneumocystis carinii pneumonia by antibodies generated from either T helper 1 or T helper 2 responses.: Infect Immun. 1997 Dec;65(12):5052-6. Unique Identifier : AIDSLINE MED/98053944; Garvy BA; Wiley JA; Gigliotti F; Harmsen AG; Trudeau Institute, Saranac Lake, New York 12983, USA.; bgarvy@northnet.org; To determine whether different antibody isotypes associated with T helper 1 (Th1) or Th2 responses are protective against Pneumocystis carinii, mice with disrupted interleukin 4 genes IL-4(-/-) mice) or gamma interferon genes (IFN-gamma(-/-) mice) along with wild-type C57BL/6 mice were immunized intratracheally agains
Differential induction of Th1 versus Th2 cytokines by group A streptococcal toxic shock syndrome isolates.: Infect Immun. 1997 Dec;65(12):5209-15. Unique Identifier : AIDSLINE MED/98053966; Norrby-Teglund A; Lustig R; Kotb M; Research Service, Veterans Affairs Medical Center, Memphis, Tennessee; 38104, USA.; The majority of group A streptococcal (GAS) isolates from patients with streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (NF) express numerous virulence factors, including several superantigens (SAgs). Purified SAgs are potent inducers of inflammatory (Th1) cytokines that contribute to the pathogene
CD8+ T cells are activated during the early Th1 and Th2 immune responses in a murine Lyme disease model.: Infect Immun. 1997 Dec;65(12):5334-7. Unique Identifier : AIDSLINE MED/98053984; Dong Z; Edelstein MD; Glickstein LJ; Department of Medicine, New England Medical Center and Tufts; University School of Medicine, Boston, Massachusetts 02111, USA.; T-helper responses following Borrelia burgdorferi infection in mice determine susceptibility to Lyme arthritis. The ratio of interleukin 4-positive, CD4+ to gamma interferon IFN-gamma)-positive, CD4+ T cells was significantly greater in infected BALB/cJ mice than in infected C3H/HeJ mice. Increased numbers of IFN-gamm
A sero-epidemiological study of the relationship between sexually transmitted agents and cervical cancer in Honduras.: Int J Cancer. 1997 Dec 10;73(6):781-5. Unique Identifier : AIDSLINE MED/98060572; Ferrera A; Baay MF; Herbrink P; Figueroa M; Velema JP; Melchers WJ; Department of Microbiology, Universidad Nacional Autonoma de Honduras,; Tegucigalpa. anabelle@gbm.hn; To investigate a possible cause-and-effect relationship between sexually transmitted diseases and cervical cancer, we performed a sero-epidemiological study on the presence of antibodies against a number of sexually transmitted agents (STAs) in patients with cervical cancer and their matched controls. In this study, w
Heterogeneous p53 mutations in a Burkitt lymphoma from an AIDS patient with monoclonal c-myc and VDJ rearrangements.: Int J Cancer. 1997 Dec 10;73(6):816-21. Unique Identifier : AIDSLINE MED/98060579; Campomenosi P; Fronza G; Ottaggio L; Roncella S; Inga A; Bogliolo M; Monti P; Assereto P; Moro F; Cutrona G; Bozzo S; Chiorazzi N; Abbondandolo A; Ferrarini M; CSTA-Mutagenesis Laboratory, National Institute for Cancer Research; (IST), Genoa, Italy.; This study investigates the timing of p53 mutations detected in the malignant cells of a Burkitt s lymphoma cell line (BRG-P) with respect to other maturation or transforming events. The BRG-P cell line, derived from an AIDS patient, was of special value since it displayed subclones that had undergone an isotype switc
Multiple imputation method for estimating incidence of HIV infection. The Multicenter Prospective HIV Study.: Int J Epidemiol. 1997 Oct;26(5):1107-14. Unique Identifier : AIDSLINE MED/98029961; Brancato G; Pezzotti P; Rapiti E; Perucci CA; Abeni D; Babbalacchio A; Rezza G; Department of Epidemiology, Lazio Region Health Authority, Rome,; Italy.; BACKGROUND: CD4+ T-lymphocyte (CD4) and platelet counts are good predictors of the maturity of HIV infection and can be used to impute the date of infection/seroconversion in individuals for whom this date is unknown. METHODS: Data from the Italian Seroconversion Study were used to develop a Weibull regression model
Risk factors for the development of non-response to first-line treatment for tuberculosis in southern Vietnam.: Int J Epidemiol. 1997 Oct;26(5):1115-20. Unique Identifier : AIDSLINE MED/98029962; Keane VP; de Klerk N; Krieng T; Hammond G; Musk AW; International Organisation for Migration, Harare, Zimbabwe.; BACKGROUND: Acquired resistance to standard chemotherapy for tuberculosis (TB) is an increasing problem worldwide. Vietnam has one of the highest incidences of TB and also has a large population of potential migrants to other countries. Since 1979 the International Organisation fo
Non-Hodgkin's lymphoma: time trends for incidence and survival in Cote-d'Or, France.: Int J Epidemiol. 1997 Oct;26(5):945-52. Unique Identifier : AIDSLINE MED/98029941; Rolland-Portal I; Tazi MA; Milan C; Couillault C; Carli PM; Registre des Hemopathies Malignes de la Cote-d'Or (equipe associee; INSERM-DGS), France.; BACKGROUND: A generally reported increased incidence of non-Hodgkin s lymphomas (NHL) and a recent evolution in treatment strategies, as well as several clinical trials suggesting improved survival, have prompted this study to evaluate time trends in incidence and prognosis of NHL. METHOD: NHL recorded by the populati
Squamous cell carcinoma of the cervix with psoas abscess-like metastasis in an HIV-negative patient.: Isr J Med Sci. 1997 Oct;33(10):674-6. Unique Identifier : AIDSLINE MED/98059291; Bar-Dayan Y; Fishman A; Levi Z; Rachmani R; Department of Medicine, Meir Hospital, Kfar-Saba, Sackler Faculty of; Medicine, Tel Aviv University, Israel.; A psoas abscess-like metastasis of squamous cell carcinoma of uterine cervix was diagnosed in a 50-year-old, HIV-negative woman. While there was complete regression of the primary tumor, the psoas cystic lesion grew in size during chemotherapy, with iliac bone destruction and invasion to the gluteus muscle. A computed
Ocular manifestations of the acquired immunodeficiency syndrome.: Hawaii Med J. 1997 Oct;56(10):285-7. Unique Identifier : AIDSLINE MED/98046857; Wong BM; Department of Surgery, University of Hawaii, John A. Burns School of; Medicine, USA.; Ophthalmologic findings in individuals with the acquired immunodeficiency syndrome (AIDS) are fairly common. A noninfectious microvasculopathy of the retina is the most frequent manifestation. Cytomegalovirus ( CMV ) retinitis is the opportunistic infection most l
Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60.: J Biol Chem. 1997 Dec 5;272(49):30595-8. Unique Identifier : AIDSLINE MED/98049511; Yamamoto T; Horikoshi M; Laboratory of Developmental Biology, Department of Cellular Biology,; Institute of Molecular and Cellular Biosciences, The University of; Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113, Japan.; Tip60, originally isolated as an HIV-1-Tat interactive protein, contains an evolutionarily conserved domain with yeast silencing factors. We demonstrate here direct biochemical evidence that this domain of Tip60 has histone acetyltransferase activity. The purified recombinant effectively acetylates H2A, H3, and H4 but
Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32.: J Biol Chem. 1997 Dec 5;272(49):30603-6. Unique Identifier : AIDSLINE MED/98049513; Benkirane M; Jin DY; Chun RF; Koup RA; Jeang KT; Molecular Virology Section, Laboratory of Molecular Microbiology,; NIAID, National Institutes of Health, Bethesda, Maryland 20892-0460,; USA.; Human chemokine receptor 5 (CCR5) functions as a co-receptor for Human immunodeficiency virus (HIV-1) infection. CCR5 is a seven-transmembrane cell surface receptor. Recently, a naturally occurring mutation of CCR5, ccr5Delta32, has been described. A small number of Caucasians are homozygously ccr5Delta32/ccr5Delta32,
The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons.: J Biol Chem. 1997 Dec 5;272(49):30662-71. Unique Identifier : AIDSLINE MED/98049523; Mummidi S; Ahuja SS; McDaniel BL; Ahuja SK; Department of Medicine, University of Texas Health Science Center at; San Antonio, San Antonio, Texas 78284-7870, USA.; Human CC chemokine receptor 5 (CCR5), mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1. To understand the molecular mechanism
The zinc fingers of HIV nucleocapsid protein NCp7 direct interactions with the viral regulatory protein Vpr.: J Biol Chem. 1997 Dec 5;272(49):30753-9. Unique Identifier : AIDSLINE MED/98049536; de Rocquigny H; Petitjean P; Tanchou V; Decimo D; Drouot L; Delaunay T; Darlix JL; Roques BP; Departement de Pharmacochimie Moleculaire et Structurale, INSERM U266,; CNRS URA D 1500, UFR des Sciences Pharmaceutiques et Biologiques,; 75270 Paris Cedex 06, France.; The 96-amino acid protein Vpr functions as a regulator of cellular processes involved in human immunodeficiency virus, type 1 (HIV-1) life cycle, in particular by interrupting cells division in the G2 phase. Incorporation of Vpr in the virion was reported to be mediated by the C-terminal domain of the Pr55(Gag) polypr
Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation.: J Biol Chem. 1997 Dec 5;272(49):30952-61. Unique Identifier : AIDSLINE MED/98049564; Jin DY; Chae HZ; Rhee SG; Jeang KT; Laboratory of Molecular Microbiology, NIAID, National Institutes of; Health, Bethesda, Maryland 20892, USA.; Reduction-oxidation (redox) plays a critical role in NF-kappaB activation. Diverse stimuli appear to utilize reactive oxygen species (e.g. hydrogen peroxide) as common effectors for activating NF-kappaB. Antioxidants govern intracellular redox status, and many such molecules can reduce H2O2. However, functionally, it
COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells.: J Biol Chem. 1997 Dec 5;272(49):31149-55. Unique Identifier : AIDSLINE MED/98049590; Rohr O; Aunis D; Schaeffer E; Unite 338 INSERM, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France.; We have recently reported that chicken ovalbumin upstream promoter transcription factor (COUP-TF) activates human immunodeficiency virus type 1 (HIV-1) gene transcription in glial and neuronal cells. Here, we have examined the role of COUP-TF in microglial cells, the major target cells for HIV-1 infection in brain. We
Immunomodulation by human seminal plasma: a benefit for spermatozoon and pathogen?: Hum Reprod. 1997 Oct;12(10):2200-7. Unique Identifier : AIDSLINE MED/98063874; Kelly RW; Critchley HO; Medical Research Council Reproductive Biology Unit, University of; Edinburgh Centre for Reproductive Biology, UK.; The immunosuppressive effect of human seminal plasma and its implications for sperm survival are reviewed. Human semen contains high concentrations of prostaglandins that can effect a cytokine-mediated switch away from a cell-mediated immune response. This effect on antigen presenting cells would induce a state of non
Human CD8+ TCR-alpha beta(+) and TCR-gamma delta(+) cells modulate autologous autoreactive neuroantigen-specific CD4+ T-cells by different mechanisms.: J Neuroimmunol. 1997 Dec;80(1-2):47-64. Unique Identifier : AIDSLINE MED/98075180; Correale J; Rojany M; Weiner LP; Department of Neurology, USC School of Medicine, Los Angeles 90033,; USA.; To investigate the regulatory interactions among autologous T-cells during the course of multiple sclerosis (MS), proteolipid protein peptide-specific CD4+ T-cell clones (TCCs) were irradiated and used as immunogens to stimulate purified populations of autologous CD8+ TCR-alpha beta+ and TCR-gamma delta+ T-cells isola
Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-beta mRNA.: J Neuroimmunol. 1997 Dec;80(1-2):65-75. Unique Identifier : AIDSLINE MED/98075181; Bai XF; Shi FD; Xiao BG; Li HL; van der Meide PH; Link H; Division of Neurology, Karolinska Institute, Huddinge University; Hospital, Stockholm, Sweden.; This study explores nasal administration of myelin basic protein MBP) as a potential means of inducing tolerance to relapsing experimental autoimmune encephalomyelitis (PR-EAE), an experimental multiple sclerosis (MS) model that was induced in DA rats by immunization with rat spinal cord homogenate and incomplete Freu
Do physicians discuss HIV and AIDS with patients? A survey of physician practices.: J Community Health. 1997 Dec;22(6):401-16. Unique Identifier : AIDSLINE MED/98067103; Haas DM; Coe RM; Saint Louis University School of Medicine, MO 63104, USA.; HIV and AIDS continue to be major concerns to the health care community and the world around them. Preventive efforts and education have been the focus of the fight against AIDS thus far. By the year 2000, 75% of physicians are expected to conduct risk-reduction counseling for patients regularly. Previous studies show
Erythema nodosum leprosum in histoid leprosy: a case report.: J Dermatol. 1997 Sep;24(9):611-4. Unique Identifier : AIDSLINE MED/98011163; Kumar V; Mendiratta V; Sharma RC; Kakar N; Bajaj P; Department of Dermatology, Lady Hardinge Medical College, New Delhi,; India.; A 28-year-old married female developed histoid papules and nodules de novo over her face, extremities, back, buttocks and thighs. She had developed erythema nodosum leprosum lesions without any antileprosy treatment. Histopathology from a histoid nodule showed well defined nodular collections of plump, spindle-shaped
Objective measures of allergic disease in children with human immunodeficiency virus infection.: J Allergy Clin Immunol. 1997 Nov;100(5):707-11. Unique Identifier : AIDSLINE MED/98049171; Bacot BK; Paul ME; Navarro M; Abramson SL; Kline MW; Hanson IC; Rosenblatt HM; Shearer WT; Baylor College of Medicine and Texas Children's Hospital, Houston; 77030, USA.; BACKGROUND: Available information suggests that IgE levels are elevated in adults infected with human immunodeficiency virus HIV), and that increased IgE levels correlate with allergic disease, with decreased CD4 counts, and with a poor prognosis. Data with respect to these factors in children are scant. OBJECTIVE: We
Serum and plasma markers of nutritional status in children infected with the human immunodeficiency virus.: J Am Diet Assoc. 1997 Dec;97(12):1377-81. Unique Identifier : AIDSLINE MED/98068144; Henderson RA; Talusan K; Hutton N; Yolken RH; Caballero B; Department of Pediatrics, Johns Hopkins University School of Medicine,; Baltimore, Md. 21287-2631, USA.; OBJECTIVE: To determine whether reduced serum or plasma protein and micronutrient levels are common in children infected with the human immunodeficiency virus (HIV) and whether these levels are different in children with growth retardation compared to those with normal growth. SUBJECTS: Children were separated into th
Absence of HTLV-1 proviral sequences in patients with lymphomatoid papulosis [letter]: J Invest Dermatol. 1997 Dec;109(6):817-8. Unique Identifier : AIDSLINE MED/98068663; Ortiz Romero PL; Vallejo A; Lopez Estebaranz JL; Garcia Saiz A; Fernandez V; Iglesias Diez L
HIV seroprevalence rates among homicide victims in New York City: 1991-1993.: J Forensic Sci. 1997 Nov;42(6):1070-3. Unique Identifier : AIDSLINE MED/98059937; Tardiff K; Marzuk PM; Leon AC; Hirsch CS; Stajic M; Portera L; Hartwell N; Department of Psychiatry, Cornell University Medical College, New; York, NY, USA.; This study assessed HIV seroprevalence in homicide victims killed in New York City in 1991-1993, using data from the Office of Chief Medical Examiner. Among 5852 homicide victims there were 344 (5.9%) victims who were HIV positive. Females were just as likely as males to be HIV positive. For females, the highest rates
Molecular analysis of the differential restriction of human immunodeficiency virus type 1 replication in neuronal cell lines.: J Gen Virol. 1997 Dec;78 ( Pt 12):3255-64. Unique Identifier : AIDSLINE MED/98062148; Hsia K; Spector DH; Spector SA; Department of Pediatrics, University of California San Diego, La Jolla; 92093-0672, USA. khsia@ucsd.edu; Human immunodeficiency virus type 1 (HIV-1) replication is restricted partially in SK-N-MC and completely in SK-N-SH neuronal cells. To investigate the molecular mechanism of this differential restriction of HIV-1 replication, cells infected with HIV-1 were analysed for their steady-state levels of: total and unintegr
Salmonella typhimurium aroA recombinants and immune-stimulating complexes as vaccine candidates for feline immunodeficiency virus.: J Gen Virol. 1997 Dec;78 ( Pt 12):3265-75. Unique Identifier : AIDSLINE MED/98062149; Tijhaar EJ; Huisman W; Huisman RC; Siebelink KH; Karlas JA; de Ronde A; van Herwijnen R; Mooi FR; Osterhaus AD; National Institute of Public Health and the Environment, Bilthoven,; The Netherlands.; Two experimental feline immunodeficiency virus (FIV) vaccines were tested, either alone or in combination, in four groups of cats (A-D). One vaccine (SL3261-FIV) was composed of live attenuated Salmonella typhimurium aroA (SL3261) strains expressing the capsid (Gag) and part of the envelope (Env) proteins of FIV. The
Role of the Fas/Fas ligand pathway in apoptotic cell death induced by the human T cell lymphotropic virus type I Tax transactivator.: J Gen Virol. 1997 Dec;78 ( Pt 12):3277-85. Unique Identifier : AIDSLINE MED/98062150; Chen X; Zachar V; Zdravkovic M; Guo M; Ebbesen P; Liu X; Department of Virus and Cancer, Danish Cancer Society, Aarhus C,; Denmark.; Two distinct human diseases have been described in association with human T cell lymphotropic virus type I (HTLV-I) infection: adult T cell leukaemia and tropical spastic paraparesis/HTLV-I-associated myelopathy. Although comprehensive understanding of specific mechanisms underlying pathogenesis of either disease has
Estimation of body composition by bioelectrical impedance in HIV-infected children [letter]: J Pediatr. 1997 Oct;131(4):648-9. Unique Identifier : AIDSLINE MED/98047910; Reilly JJ; Fontana M
Enteric cryptosporidiosis in pediatric HIV infection.: J Pediatr Gastroenterol Nutr. 1997 Aug;25(2):182-7. Unique Identifier : AIDSLINE MED/97396741; Guarino A; Castaldo A; Russo S; Spagnuolo MI; Canani RB; Tarallo L; DiBenedetto L; Rubino A; Department of Paediatrics, University Federico II, Naples, Italy.; BACKGROUND: Enteric cryptosporidiosis is a frequent problem in adults with human immunodeficiency virus (HIV) infection, but little is known of its features in children. The aim of this study was to investigate the incidence and the clinical features of cryptosporidiosis in HIV-infected children. METHODS: Thirty-five
Gastrointestinal cytomegalovirus infection complicating Crohn's disease in an adolescent without AIDS.: J Pediatr Gastroenterol Nutr. 1997 Aug;25(2):210-3. Unique Identifier : AIDSLINE MED/97396746; Drouin E; Seidman E; Russo P; Deslandres C; Department of Pediatrics, Ste-Justine Hospital, University of; Montreal, Quebec, Canada.
Nonsymmetrically substituted cyclic urea HIV protease inhibitors.: J Med Chem. 1997 Dec 5;40(25):4079-88. Unique Identifier : AIDSLINE MED/98069696; Wilkerson WW; Dax S; Cheatham WW; DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington,; Delaware 19880-0500, USA.; A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis, pharmacol
T cell activation in vivo by dengue virus infection.: J Clin Lab Immunol. 1995;46(1):35-40. Unique Identifier : AIDSLINE MED/98030041; Kurane I; Innis BL; Hoke CH Jr; Eckels KH; Meager A; Janus J; Ennis FA; Department of Medicine, University of Massachusetts Medical Center,; Worcester 01655, USA.; It is accepted that T cells play a critical role during virus infections; however, T cell responses in vivo in acute stage of virus infection are not understood. We examined T cell activation in vivo in two volunteers who developed dengue fever in response to vaccination with a candidate live dengue vaccine. Serial pl
Kaposi's sarcoma and Kaposi's sarcoma associated herpesvirus human herpesvirus 8): where are we now? [editorial; comment]: J Natl Cancer Inst. 1997 Dec 17;89(24):1829-31. Unique Identifier : AIDSLINE MED/98074976; Chang Y
Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells [see comments]: J Natl Cancer Inst. 1997 Dec 17;89(24):1868-74. Unique Identifier : AIDSLINE MED/98074985; Davis MA; Sturzl MA; Blasig C; Schreier A; Guo HG; Reitz M; Opalenik SR; Browning PJ; Department of Medicine, Vanderbilt University, Nashville, TN, USA.; BACKGROUND: Human herpesvirus 8 (HHV-8) DNA sequences have been detected in Kaposi s sarcoma, in primary effusion lymphoma (an unusual high-grade non-Hodgkin s lymphoma seen primarily in patients with acquired immunodeficiency syndrome [AIDS]), and in Castleman s disease (a rare ly
Body mass index: a prognosis factor among HIV seropositive malnourished children.: J Trop Pediatr. 1997 Oct;43(5):301-3. Unique Identifier : AIDSLINE MED/98081402; Beau JP; Imboua-Coulibaly L; Pediatrics Department, Treichville Hospital, Abidjan, Cote d'Ivoire.
Risk factors and clinical presentation of acute primary HIV infection in India.: JAMA. 1997 Dec 17;278(23):2085-9. Unique Identifier : AIDSLINE MED/98065681; Bollinger RC; Brookmeyer RS; Mehendale SM; Paranjape RS; Shepherd ME; Gadkari DA; Quinn TC; Division of Infectious Diseases, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Md 21205, USA.; CONTEXT: Most previous studies of clinical presentation and risk factors in early human immunodeficiency virus (HIV) infection have relied on retrospective analyses and referred seroconverters, and thus were subject to possible bias. OBJECTIVES: To apply a method based on measurement of prevalent HIV-1 p24 antigenemia
Spread of HIV infection in married monogamous women in India.: JAMA. 1997 Dec 17;278(23):2090-2. Unique Identifier : AIDSLINE MED/98065682; Gangakhedkar RR; Bentley ME; Divekar AD; Gadkari D; Mehendale SM; Shepherd ME; Bollinger RC; Quinn TC; National AIDS Research Institute, Pune, India.; CONTEXT: A high prevalence of human immunodeficiency virus (HIV) infection in female sex workers (FSWs) and men who attend sexually transmitted disease (STD) clinics poses a risk for spread of infection to other populations. OBJECTIVE: To examine spread of HIV to a low-risk population by comparing prevalence of, and r
Effect of CCR2 and CCR5 variants on HIV disease: abstract and commentary.: JAMA. 1997 Dec 17;278(23):2113-4. Unique Identifier : AIDSLINE MED/98065688; Collman RG; Pulmonary and Critical Care Division, University of Pennsylvania; School of Medicine, Philadelphia, USA. collmanr@mail.med.upenn.edu
From the Centers for Disease Control and Prevention. Update: perinatally acquired HIV/AIDS--United States, 1997.: JAMA. 1997 Dec 24-31;278(24):2135-6. Unique Identifier : AIDSLINE MED/98077477
[A case of AIDS with disseminated Mycobacterium kansasii infection in which Mycobacterium, avium complex was also detected from his sputum repeatedly]: Kekkaku. 1997 Oct;72(10):573-7. Unique Identifier : AIDSLINE MED/98047515; Sasaki Y; Yamagishi F; Suzuki K; Saitoh M; Izumizaki M; Division of Respiratory Medicine, National Chiba Higashi Hospital,; Japan.; A 43 year-old Japanese male was admitted to our hospital because of productive cough and fever. He was diagnosed as acquired immunodeficiency syndrome (AIDS) in 1994. Laboratory findings were as follows: WBC was 3200/microliter, CD4+ T lymphocyte count was 22/microliter. His chest X-ray film taken on admission showed
[The year of the world aids day: children in a world of AIDS]: Lakartidningen. 1997 Nov 26;94(48):4501-2. Unique Identifier : AIDSLINE MED/98076619; Belfrage E; Bohlin AB; Arneborn M; Lidin-Janson G; Lidman K; Lindgren S; Ottenblad C; Danderyds barnklinik/barndivisionen, Karolinska sjukhuset, Stockholm.
Benign symmetric lipomatosis associated with protease inhibitors [letter]: Lancet. 1997 Nov 29;350(9091):1596. Unique Identifier : AIDSLINE MED/98055059; Hengel RL; Watts NB; Lennox JL
AIDS cost takes its toll in Canada [news]: Lancet. 1997 Nov 29;350(9091):1608. Unique Identifier : AIDSLINE MED/98055069; Kondro W
World Bank oil-pipeline project designed to prevent HIV transmission [news]: Lancet. 1997 Nov 29;350(9091):1608. Unique Identifier : AIDSLINE MED/98055068; Kigotho AW
What is required of an HIV vaccine?: Lancet. 1997 Nov 29;350(9091):1617-21. Unique Identifier : AIDSLINE MED/98055071; Bangham CR; Phillips RE; Department of Immunology, Imperial College School of Medicine, St; Mary's Hospital, London, UK.; Mounting evidence suggests that the early dissemination of HIV in human beings evokes an immune response that is responsible for containment of the infection during the long symptom-free period. Loss of this immune control coincides with a final escalation of the viraemia and the terminal failure of the immune system.
Illegal drug use and HIV-1 infection in Columbia [letter]: Lancet. 1997 Nov 29;350(9091):1635. Unique Identifier : AIDSLINE MED/98055090; Miguez MJ; Page B; Baum MK
Human herpesvirus 8 variants in sarcoid tissues.: Lancet. 1997 Dec 6;350(9092):1655-61. Unique Identifier : AIDSLINE MED/98063156; Di Alberti L; Piattelli A; Artese L; Favia G; Patel S; Saunders N; Porter SR; Scully CM; Ngui SL; Teo CG; PHLS Virus Reference Division, Central Public Health Laboratory,; London, UK.; BACKGROUND: The cause of sarcoidosis is unknown, although mycobacteria have been implicated. We examined sarcoid tissues for human herpesvirus 8 (HHV-8) in addition to mycobacterial genomic sequences. METHODS: Biopsy samples from 17 patients with sarcoidosis were studied (eight transbronchial, 27 lymph node, two skin,
HIV epidemic could number 40 million by year 2000 [news]: Lancet. 1997 Dec 6;350(9092):1683. Unique Identifier : AIDSLINE MED/98063172; Morris K
Trial to reduce vertical transmission of HIV-1 on schedule in Uganda [news]: Lancet. 1997 Dec 6;350(9092):1683. Unique Identifier : AIDSLINE MED/98063173; Kigotho AW
Final Krever report paints picture of regulatory dysfunction [news]: Lancet. 1997 Dec 6;350(9092):1688. Unique Identifier : AIDSLINE MED/98063175; Kondro W
The antigenic sites of trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties.: Life Sci. 1997;61(23):2291-303. Unique Identifier : AIDSLINE MED/98069990; Mulot S; Chung KK; Li XB; Wong CC; Ng TB; Shaw PC; Department of Biochemistry, The Chinese University of Hong Kong,; Shatin, NT.; Trichosanthin (TCS) fragments were produced by Tn1000 deletion mutagenesis and by cyanogen bromide (CNBr) cleavage and their immunoreactivity was examined by incubating with various antibodies. Twelve C-terminally truncated TCS variants were successfully synthesized under the control of a T7 RNA driven promoter. The s
Clinical problem-solving. A hidden agenda.: N Engl J Med. 1998 Jan 1;338(1):46-50. Unique Identifier : AIDSLINE MED/98069945; Landor M; Albert Einstein College of Medicine and the Department of Medicine,; Catholic Medical Center of Brooklyn and Queens, New York, USA.
Bring AIDS to the forefront [news]: N J Med. 1997 Nov;94(11):12. Unique Identifier : AIDSLINE MED/98046924
"The law is a ass--a idiot" [editorial]: N J Med. 1997 Nov;94(11):19-20. Unique Identifier : AIDSLINE MED/98046925; Slobodies HD
Confronting AIDS in older adults.: N J Med. 1997 Nov;94(11):39-41. Unique Identifier : AIDSLINE MED/98046929; Berlin B; A 57-year-old corporate executive, married with three grown children, began suffering from severe flu-like symptoms and weight loss. Hospitalized for a week, he was tested for chronic fatigue syndrome and mononucleosis. Finally, with no change in his symptoms, his physician recommended an HIV test. The results were po
Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome.: Pediatr Pulmonol. 1997 Nov;24(5):324-30. Unique Identifier : AIDSLINE MED/98071481; Deerojanawong J; Chang AB; Eng PA; Robertson CF; Kemp AS; Department of Thoracic Medicine, Royal Children's Hospital, Melbourne,; Victoria, Australia.; Pulmonary disease is a common presenting feature and complication of T-cell immunodeficiency. We retrospectively reviewed 15 children with severe combined immune deficiency (SCID) and 19 children with DiGeorge syndrome at the time of their first presentation to the Royal Children s Hospital in the 15-year period from
Surfactant therapy improves pulmonary function in infants with Pneumocystis carinii pneumonia and acquired immunodeficiency syndrome.: Pediatr Pulmonol. 1997 Nov;24(5):370-3. Unique Identifier : AIDSLINE MED/98071487; Creery WD; Hashmi A; Hutchison JS; Singh RN; Department of Pediatrics, University of Ottawa, Ontario, Canada.; Pneumocystis carinii pneumonia (PCP) is an important cause of acute respiratory failure in HIV-infected children. PCP may initiate acute respiratory distress syndrome (ARDS) by adversely affecting surfactant physiology. We report improved pulmonary function following administration of bovine lipid extract surfactant t
Chest radiographic data acquisition and quality assurance in multicenter studies.: Pediatr Radiol. 1997 Nov;27(11):880-7. Unique Identifier : AIDSLINE MED/98030638; Cleveland RH; Schluchter M; Wood BP; Berdon WE; Boechat MI; Easley KA; Meziane M; Mellins RB; Norton KI; Singleton E; Trautwein L; Department of Radiology, Children's Hospital, 300 Longwood Avenue,; Boston, MA 02115, USA.; BACKGROUND: Multicenter studies rely on data derived from different institutions. Forms can be designed to standardize the reporting process allowing reliable comparison of data. OBJECTIVE: The purpose of the report is to provide a standardized method, developed as a part of a multicenter study of vertically transmitt
HHV-8 (KSHV) does not establish latency in prostate cancer cell lines.: Prostate. 1997 Dec 1;33(4):286-8. Unique Identifier : AIDSLINE MED/98059351; Munker R; Tasaka T; Park D; Miller CW; Koeffler HP; Division of Hematology, UCLA Cedars Sinai Medical Center, USA.; munker@gsf.de; BACKGROUND: HHV-8 is a new herpesvirus found in lesions of Kaposi s sarcoma and some lymphoproliferative diseases. More recently, a report stated that normal prostate tissue also contains the virus. METHODS: The expression of HHV-8 was examined by a sensitive reverse-transcriptase PCR for the viral genes ORF 72, ORF 7
The case of the creeping papules.: Postgrad Med. 1997 Dec;102(6):41-2. Unique Identifier : AIDSLINE MED/98069655; Mishriki YY; Lehigh Valley Hospital, Allentown, PA 18103, USA.
Anti-idiotype RNA selected with an anti-nuclear export signal antibody is actively transported in oocytes and inhibits Rev- and cap-dependent RNA export.: Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12839-44. Unique Identifier : AIDSLINE MED/98058731; Hamm J; Huber J; Luhrmann R; Department of Biochemistry, University of Dundee, United Kingdom.; The anti-idiotype approach is based on the assumption that an antibody specific for a receptor-binding domain of a ligand could be structurally related to the receptor. Therefore, a structural mimic of a receptor-binding domain, selected with an anti-ligand antibody, might be a functional substrate for the receptor. T
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.: Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13193-7. Unique Identifier : AIDSLINE MED/98058791; Chun TW; Stuyver L; Mizell SB; Ehler LA; Mican JA; Baseler M; Lloyd AL; Nowak MA; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA. twchun@nih.gov; Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to undetectable levels, it is unclear what the effects of these regime
Structure-activity and mechanism studies on silicon phthalocyanines with Plasmodium falciparum in the dark and under red light.: Photochem Photobiol. 1997 Aug;66(2):282-7. Unique Identifier : AIDSLINE MED/97423197; Zhao XJ; Lustigman S; Kenney ME; Ben-Hur E; V.I. Technologies, Inc. (VITEX), New York, NY 10032, USA.; Syntheses for the new photosensitizers HOSiPcOSi(CH3)2(CH2)3N(CH1)1 or 3(CH3)2, Pc 34 and Pc 25, have been developed and the order of activity of these photosensitizers and the previously reported photosensitizer Pc 4, HOSiPcOSi(CH3)2(CH2)3N(CH3)2, in the dark and with broad-band red light toward Plasmodium falciparum
Photoinactivation of virus infectivity by hypocrellin A.: Photochem Photobiol. 1997 Nov;66(5):697-700. Unique Identifier : AIDSLINE MED/98045301; Hirayama J; Ikebuchi K; Abe H; Kwon KW; Ohnishi Y; Horiuchi M; Shinagawa M; Ikuta K; Kamo N; Sekiguchi S; Hokkaido Red Cross Blood Center, Sapporo, Japan.; We investigated the photoinactivation of virus infectivity by hypocrellin A and its mechanism. The titers of vesicular stomatitis virus (VSV) and human immunodeficiency virus type 1 HIV-1), both of which are enveloped viruses, were reduced upon illumination with hypocrellin A in a concentration-dependent manner, where
[Knowledge about AIDS prevention among professionals and students in health care]: Rev Gaucha Enferm. 1996 Jul;17(2):124-31. Unique Identifier : AIDSLINE MED/97423338; de Oliveira AD; Viegas CR; Sabka E; Guerra M; Baltazar R; This work is a exploratory research based on the analysis of the answers to the questionnaires of 52 students and health care professionals knowledge about AIDS sexual prevention, biosecurity, diagnosis tests, patients and workers rights and the modifications of nursing and medical care to this kind of disease.
[HIV infection in old age: an epidemiological and clinical study in 42 patients in the Community of Madrid]: Rev Clin Esp. 1997 Oct;197(10):684-9. Unique Identifier : AIDSLINE MED/98058320; Martinez Hernandez PL; Valencia Ortega ME; Pena Sanchez de Rivera JM; Soriano Vazquez V; Gonzalez-Lahoz J; Arnalich Fernandez F; Lopez Gay D; Poveda Gomez F; Camacho Siles J; Magallon Martinez M; Gonzalez Garcia J; Vazquez Rodriguez JJ; Servicio de Medicina Interna (Unidad VIH), Centro Nacional de; Investigacion Clinica y Medicina Preventiva, Madrid.; A cross-sectional study was conducted at diagnosis of HIV infection in 42 patients aged > or = 60 years attended in two hospitals in the Madrid Community. Clinical and epidemiologic characteristics were retrospectively analyzed. Mean age was 64 years, 38 patients (90.4%) were males, and 24 (57.1%) met the AIDS criteri
[Varicella pneumonia in the adult. A review of 25 cases]: Rev Clin Esp. 1997 Oct;197(10):690-2. Unique Identifier : AIDSLINE MED/98058321; Aleman Llanso C; Garcia Quintana AM; Alegre Martin J; Recio Iglesias J; Falco Ferrer V; Fernandez de Sevilla Ribosa T; Servicio de Medicina Interna, Hospital General Universitario Vall; d'Hebron, Barcelona.; OBJECTIVE: To study the clinical, therapeutic, and evolutive features in 25 patients with the diagnosis of varicella pneumonia VP) in the last 15 years. PATIENTS AND METHODS: The diagnosis was established by clinical and radiologic criteria in the course of varicella infection. The antecedents of smoking habit, pregna
[HIV infection and pulmonary carcinoma (letter; comment)]: Rev Clin Esp. 1997 Oct;197(10):724. Unique Identifier : AIDSLINE MED/98058331; Vivente de Vera Floristan C; Puig Ganau T; Gazquez Sistere I; Rubio Caballero M
[Renal complications in HIV-1 infection]: Rev Med Chil. 1997 Jan;125(1):95-8. Unique Identifier : AIDSLINE MED/97476792; Mery JP; Hopital Bichat, Paris, Francia.; Renal involvement in AIDS may be specific or unspecific. Unspecific lesions, the most common, are usually an acute tubular necrosis produced by hemodynamic, infectious or electrolytic alterations that lead to an acute renal failure or drug nephrotoxicity. Specific lesions are segmental and focal hyalinosis, immune com
[Education by couples and prevention of AIDS]: Rev Infirm. 1997 Jul;(29):69-70. Unique Identifier : AIDSLINE MED/97429150; Le Garzennec P
[Iron metabolism in patient infected by human immunodeficiency virus type 1]: Sangre (Barc). 1997 Oct;42(5):345-9. Unique Identifier : AIDSLINE MED/98020160; Arevalo Velasco A; Mateo Rodriguez F; Sanchez Perez MA; Alonso Claudio G; Perez Arellano JL; Fuertes Martin A; Servicio de Medicina Interna II, Hospital Universitario de Salamanca.; BACKGROUND: The aim of this work was to assess the major iron metabolism values in patients infected by human immunodeficiency virus (HIV), and to evaluate the correlation between these data and the immunological status of the patients as expressed by CD4 lymphocyte count. PATIENTS AND METHODS: Seventy-one patients in
[T-cell receptor repertoire in a CD4+ CD57+ population]: Sangre (Barc). 1997 Oct;42(5):399-400. Unique Identifier : AIDSLINE MED/98020169; Quiros-Roldan E; Sottini A; Signoniri S; Primi D; Imberti L; Consorcio per le Biotecnologie e terzo, Servizio analisi, Spedali; Civili, Brescia, Italia.
[T-cell-rich B-cell lymphoma. Presentation of 3 cases (see comments)]: Sangre (Barc). 1997 Oct;42(5):419-22. Unique Identifier : AIDSLINE MED/98020174; Rodriguez JN; Borrero JJ; Fernandez-Jurado A; Creagh R; Martino ML; Aguayo M; Prados D; Servicio de Hematologia, Hospital Juan Ramon Jimenez, Huelva.; T-cell-rich B-cell lymphoma (TBL) is a rare entity not included in the classical classifications of non-Hodgkin s lymphomas NHL), presenting usually at diagnosis in advanced stages and with extranodal involvement. Its differential diagnosis, based on immunophenotyping technics, include other entities with different tr
[Interaction of gag polyprotein-precursors p55 and p48 with p160gag-pol during formation of virus-like particles of HIV-1 with recombinant strains of vaccinia virus]: Vopr Virusol. 1997 Sep-Oct;42(5):205-8. Unique Identifier : AIDSLINE MED/98009253; Iordanskii SN; Lideman LF; Chikova AK; Gibadulin RA; The polypeptide composition of HIV-I virus-like particles produced by CV-I cells during mono- and coinfection with recombinant vaccinia virus (rVV) strains containing the whole p55) and carboxyterminal truncated (p48) gag genes and gag-pol sequence is studied. In monoinfection both the gag-strains actively produced vi
A comparison of prevalence rates of genital ulcers among persons attending a sexually transmitted disease clinic in Jamaica.: West Indian Med J. 1997 Sep;46(3):67-71. Unique Identifier : AIDSLINE MED/98027554; Brathwaite AR; Figueroa JP; Ward E; Epidemiology Unit, Ministry of Health, Jamaica.; Two cross-sectional surveys were undertaken, from December 1982 to August 1983 and from November 1990 to January 1991, to estimate the prevalence rates of genital ulcer disease (GUD) in all patients presenting with a new sexually transmitted disease STD) complaint to the STD clinic at the Comprehensive Health Centre i
[The influence of ricin on the course of experimental infections of mice with Trichinella spiralis]: Wiad Parazytol. 1997;43(2):179-83. Unique Identifier : AIDSLINE MED/98041998; Karmanska K; Houszka M; Widyma A; Stefaniak E; Instytut Parazytologii PAN im. W. Stefanskiego, Wroclaw.; Mice received 5 ng of ricin 24 hours after infection (experiment I) or 1 ng of ricin twice, 24 hours and 17 days of infection experiment II). Animals were killed in 7, 14, 21, 28, 35, 42 and 60 days after infection. In the jejunum and masseter muscle sections, CD4+ and CD8+ lymphocytes, mast cells and eosinophils were
Interferon therapy for Japanese hemophiliacs with chronic hepatitis C.: Acta Paediatr Jpn. 1997 Oct;39(5):556-8. Unique Identifier : AIDSLINE MED/98030103; Miura T; Meguro T; Takayama S; Yamada K; Department of Pediatrics, Haga Red Cross Hospital, Tochigi, Japan.; Eight Japanese hemophiliacs with chronic hepatitis C (CHC) received interferon (IFN) therapy and four of them (50%) responded completely. Non-responders included 3 double-infected patients: 1 with hepatitis B virus (HBV) and 2 with human immunodeficiency virus-1 (HIV-1). In one of the patients with HIV-1 double infect
Comparison of T2-weighted and fluid-attenuated inversion-recovery fast spin-echo MR sequences in intracerebral AIDS-associated disease [see comments]: AJNR Am J Neuroradiol. 1997 Oct;18(9):1601-9. Unique Identifier : AIDSLINE MED/98033129; Thurnher MM; Thurnher SA; Fleischmann D; Steuer A; Rieger A; Helbich T; Trattnig S; Schindler E; Hittmair K; Department of Radiology, University of Vienna, Austria.; PURPOSE: To compare the value of fast fluid-attenuated inversion-recovery (FLAIR) with T2-weighted fast spin-echo MR imaging in the detection of acquired immunodeficiency virus AIDS)-related lesions of the brain. METHODS: Forty-four human immunodeficiency virus (HIV)-positive patients were examined with both sequences
Fluid-attenuated inversion-recovery fast spin-echo MR: a clinically useful tool in the evaluation of neurologically symptomatic HIV-positive patients [comment]: AJNR Am J Neuroradiol. 1997 Oct;18(9):1611-6. Unique Identifier : AIDSLINE MED/98033130; Post MJ; Department of Radiology, University of Miami School of Medicine, Fla,; USA.
Adenoidal width and HIV factors.: AJNR Am J Neuroradiol. 1997 Oct;18(9):1721-5. Unique Identifier : AIDSLINE MED/98033145; Yousem DM; Loevner LA; Tobey JD; Geckle RJ; Bilker WB; Chalian AA; Department of Radiology, University of Pennsylvania Medical Center,; Philadelphia 19104, USA.; PURPOSE: To determine the factors that correspond to adenoidal hypertrophy, often prominent in human immunodeficiency virus HIV)-positive patients. METHODS: The sagittal T1-weighted MR images of 21 HIV-positive patients (age range, 25 to 50 years; mean, 37 years) and 21 healthy control subjects (age range, 24 to 55 ye
HIV management update [letter]: Am Fam Physician. 1997 Dec;56(9):2186, 2188. Unique Identifier : AIDSLINE MED/98066511; Hamada OL
Occupational infections in health care workers: prevention and intervention.: Am Fam Physician. 1997 Dec;56(9):2291-300, 2303-6. Unique Identifier : AIDSLINE MED/98066518; Swinker M; East Carolina University School of Medicine, Greenville, North; Carolina.; Health care workers may be exposed to a variety of infections as they carry out their job responsibilities. Guidelines have been issued for prophylaxis following exposure to blood or body fluids known to be infected with the human immunodeficiency virus. Hepatitis B vaccine must be offered to all workers who may be ex
AAP develops recommendations for the evaluation and treatment of HIV-exposed infants.: Am Fam Physician. 1997 Dec;56(9):2351-4. Unique Identifier : AIDSLINE MED/98066519; Morey SS
First combination drug for patients with HIV [news]: Am Fam Physician. 1997 Dec;56(9):2356. Unique Identifier : AIDSLINE MED/98066520
Treatment of early AIDS dementia in intravenous drug users: high versus low dose peptide T.: Am J Drug Alcohol Abuse. 1997 Nov;23(4):543-53. Unique Identifier : AIDSLINE MED/98033841; Kosten TR; Rosen MI; McMahon TL; Bridge TP; O'Malley SS; Pearsall R; O'Connor PG; Department of Psychiatry, VA Connecticut (Psychiatry 116A), West; Haven, CT 06516, USA.; This placebo-controlled, double blind, cross-over study tested the efficacy of two different doses of Peptide T in the treatment of nine intravenous drug users with early AIDS dementia who were also receiving methadone and
Crack users in east Harlem, New York and Philadelphia, Pennsylvania: HIV-related risk behaviors and predictors of serostatus.: Am J Drug Alcohol Abuse. 1997 Nov;23(4):555-67. Unique Identifier : AIDSLINE MED/98033842; Deren S; Kotranski L; Beardsley M; Collier K; Tortu S; Semaan S; Lauby J; Hamid R; National Development and Research Institutes, Inc. New York, New York,; USA.; Crack use has been associated with increased risk for HIV seropositivity. This study was undertaken to examine HIV-related risk behaviors among crack users in East Harlem, New York and Philadelphia, Pennsylvania, two northeastern communities which have reported extensive crack use. Crack users recruited in East Harlem
A comparison of HIV-positive and HIV-negative crack users enrolled in a residential addiction treatment program.: Am J Drug Alcohol Abuse. 1997 Nov;23(4):569-80. Unique Identifier : AIDSLINE MED/98033843; Kingree JB; Glasford MT; Jones-Allen M; Comprehensive Addiction Rehabilitation Programs of Georgia, Inc.; Decatur, USA.; This study compared 96 HIV-Positive (HIV+) and 357 HIV-Negative HIV-) crack users who were participating in the same drug-free, residential treatment program. Comparisons were made on sociodemographic, health, criminal justice, psychosocial, and recovery motivation variables. As predicted, the HIV(+) participants were
Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's disease.: Am J Pathol. 1997 Dec;151(6):1517-22. Unique Identifier : AIDSLINE MED/98065959; Parravinci C; Corbellino M; Paulli M; Magrini U; Lazzarino M; Moore PS; Chang Y; Department of Pathology, University of Milano, L. Sacco Hospital,; Milan, Italy.; Castleman s disease is a rare B cell lymphoproliferative disorder related to excess interleukin-6 (IL-6)-like activity. Kaposi s sarcoma-associated herpesvirus (KSHV or HHV8), which encodes a functional cytokine (vIL-6), has been found in some patients with Castleman s disease. Lymph nodes from 14 HIV-seronegative Cas
Lymphocyte recruitment and the kinetics of adhesion receptor expression during the pulmonary immune response to particulate antigen.: Am J Pathol. 1997 Dec;151(6):1715-27. Unique Identifier : AIDSLINE MED/98065980; Wolber FM; Curtis JL; Milik AM; Fields T; Seitzman GD; Kim K; Kim S; Sonstein J; Stoolman LM; Department of Pathology, University of Michigan Medical Center, Ann; Arbor 48109-0602, USA.; The selectins and beta2 integrins participate in the recruitment of neutrophils in acute pulmonary inflammation. However, the cell adhesion receptors that mediate lymphocyte trafficking into the lung have not been defined. This study examined the relationship between cell adhesion molecules on the pulmonary vasculatur
Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis.: Am J Pathol. 1997 Dec;151(6):1751-8. Unique Identifier : AIDSLINE MED/98065983; Mavalia C; Scaletti C; Romagnani P; Carossino AM; Pignone A; Emmi L; Pupilli C; Pizzolo G; Maggi E; Romagnani S; Institute of Internal Medicine and Immunoallergology, University of; Florence, Italy.; The pattern of cytokine production of skin-infiltrating T cells from patients with progressive systemic sclerosis was investigated. Most CD4+ T-cell clones generated from skin biopsy specimens showed a type 2 helper (Th2) cytokine profile production of interleukin-4, but no interferon (IFN)-gamma). High interleukin-4
Famciclovir for the suppression of symptomatic and asymptomatic herpes simplex virus reactivation in HIV-infected persons. A double-blind, placebo-controlled trial.: Ann Intern Med. 1998 Jan 1;128(1):21-8. Unique Identifier : AIDSLINE MED/98069616; Schacker T; Hu HL; Koelle DM; Zeh J; Saltzman R; Boon R; Shaughnessy M; Barnum G; Corey L; University of Washington, Seattle, USA.; BACKGROUND: Herpes simplex virus (HSV) infection is one of the most common opportunistic infections in HIV-infected persons. However, most documentation of the effectiveness of antiviral therapy in reducing HSV reactivation is anecdotal. OBJECTIVE: To evaluate the quantitative effect of antiviral therapy on the freque
Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons.: Ann Neurol. 1997 Dec;42(6):847-56. Unique Identifier : AIDSLINE MED/98065734; Lannuzel A; Barnier JV; Hery C; Huynh VT; Guibert B; Gray F; Vincent JD; Tardieu M; Laboratoire Virus, Neurone, Immunite, Faculte de Medecine Paris-Sud,; Universite Paris-Sud, France.; Detection of apoptotic neurons and microglial cells in the brains of human immunodeficiency virus type 1 (HIV-1)-infected patients has suggested that programmed cell death may be implicated in the physiopathology of HIV-1 encephalopathy. To analyze in vitro the intracellular signals induced by HIV-1 in human neurons a
Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center.: Ann Neurol. 1997 Dec;42(6):963-72. Unique Identifier : AIDSLINE MED/98065747; Masliah E; Heaton RK; Marcotte TD; Ellis RJ; Wiley CA; Mallory M; Achim CL; McCutchan JA; Nelson JA; Atkinson JH; Grant I; Department of Neurosciences, University of California, San Diego, La; Jolla 92093-0624, USA.; To determine the neuropathological substrate of human immunodeficiency virus (HIV)-associated neurocognitive disorders, we examined persons with acquired immunodeficiency syndrome before their death and related their antemortem neuropsychological performance to postmortem indicators of HIV encephalitis, viral burden,
A temporal study of TPN-induced changes in gut-associated lymphoid tissue and mucosal immunity.: Arch Surg. 1997 Dec;132(12):1303-9. Unique Identifier : AIDSLINE MED/98065792; King BK; Li J; Kudsk KA; Department of Surgery, The University of Tennessee, Memphis, USA.; BACKGROUND: Total parenteral nutrition (TPN) is associated with decreases in small-intestinal gut-associated lymphoid tissue GALT) T cells, B cells, and IgA levels and impairs IgA-mediated defenses in the respiratory tract. The impaired respiratory tract defenses are speculated to be due to reduced respiratory tract I
Splenic abscess: another look at an old disease.: Arch Surg. 1997 Dec;132(12):1331-5; discussion 1335-6. Unique Identifier : AIDSLINE MED/98065797; Phillips GS; Radosevich MD; Lipsett PA; Department of Surgery, Johns Hopkins University School of Medicine,; Johns Hopkins Medical Institutions, Baltimore, Md 21287-4605, USA.; OBJECTIVE: To study the changes in the incidence, causes, bacteriologic profile, and management of a splenic abscess. DESIGN: Retrospective case study. SETTING: Tertiary, university referral center. PATIENTS: Thirty-nine patients with a splenic abscess. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Demographics, signs a
Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.: Biochem J. 1997 Nov 15;328 ( Pt 1):317-20. Unique Identifier : AIDSLINE MED/98028690; Verri A; Priori G; Spadari S; Tondelli L; Focher F; Istituto di Genetica Biochimica ed Evoluzionistica, Consiglio; Nazionale delle Ricerche, Pavia, Italy.; Our discovery that Herpes virus thymidine kinase (TK) and cellular deoxycytidine kinase lack enantioselectivity, being able to phosphorylate both D- and L-enantiomers of the substrate, suggested the use of unnatural L-nucleoside analogues as antiviral drugs (Herpes, hepatitis and immunodeficiency viruses). Several L-n
AIDS prevention with local implementors--overcoming obstacles.: World Health Forum. 1997;18(2):215-7. Unique Identifier : AIDSLINE MED/98054722; Setel P; National Centre for Epidemiology, Australian National University,; Canberra, ACT, Australia.
Trials and tribulations: ethical dilemmas in HIV therapy [editorial]: Curr Opin Immunol. 1997 Oct;9(5):625-7. Unique Identifier : AIDSLINE MED/98035203; Weber J
HIV co-receptor identification: good or bad news for drug discovery? [editorial]: Curr Opin Immunol. 1997 Oct;9(5):628-30. Unique Identifier : AIDSLINE MED/98035204; Landau NR
[The cellular immunologic status of the laryngeal cancer patients]: Chung Hua Erh Pi Yen Hou Ko Tsa Chih. 1996;31(2):107-9. Unique Identifier : AIDSLINE MED/98048751; Huang Z; Han D; Bian Y; Beijing Tongren Hospital.; To observe the cellular immunologic status of the laryngeal cancer patients 70 laryngeal cancer patients were examined with immunohistochemical method. The peripheral blood T lymphocyte subsets were detected and local tumor infiltrative T lymphocytes were observed. The results showed that the cellular immunologic func
Silent infection of macaques inoculated with low-dose SIVmac251/spl [letter]: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1355-6. Unique Identifier : AIDSLINE MED/98022611; Petry H; Dittmer U; Stahl-Hennig C; Jurkiewicz E; Hunsmann G; Luke W
HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1357-66. Unique Identifier : AIDSLINE MED/98022612; Zhang L; Carruthers CD; He T; Huang Y; Cao Y; Wang G; Hahn B; Ho DD; The Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; Identification of the chemokine receptors CCR5 and CXCR4 as the major coreceptors for HIV-1 entry has greatly assisted our understanding of HIV-1 pathogenesis, transmission, and tropism. However, most of our current knowledge on coreceptor usage comes from studies using HIV-1 strains or env genes derived from the gene
C-C chemokine RANTES and HIV long terminal repeat-driven gene expression.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1367-71. Unique Identifier : AIDSLINE MED/98022613; Garzino-Demo A; Arya SK; Devico AL; Cocchi F; Lusso P; Gallo RC; Institute of Human Virology, Medical Biotechnology Center, University; of Maryland Biotechnology Institute and School of Medicine, Baltimore; 21201, USA.; The C-C chemokines RANTES, MIP-1alpha, and MIP-1beta have been characterized as constituents of an HIV- and SIV-suppressive factor released by CD8+ cells. Furthermore, it has been demonstrated that chemokine receptors cooperate in HIV entry. However, these proteins are also known to have an effect on multiple intracel
Low frequency of CCR5delta32 allele among Greeks in Cyprus.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1373-4. Unique Identifier : AIDSLINE MED/98022614; Christodoulou C; Poullikas M; Neumann AU; Kostrikis LG; The Cyprus Institute of Neurology and Genetics, Nicosia.
Early postinfection antiviral treatment reduces viral load and prevents CD4+ cell decline in HIV type 2-infected macaques.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1375-81. Unique Identifier : AIDSLINE MED/98022615; Watson A; McClure J; Ranchalis J; Scheibel M; Schmidt A; Kennedy B; Morton WR; Haigwood NL; Hu SL; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA.; Reports of significant reductions in plasma viral load by anti-HIV drugs have raised the possibility that antiviral therapy, if initiated sufficiently early, may result in sustained control of infection and prolonged clinical benefits. We evaluated the effects of intervention coincident with infection using an antivir
Course of specific T lymphocyte cytotoxicity, plasma and cellular viral loads, and neutralizing antibody titers in 17 recently seroconverted HIV type 1-infected patients.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1383-94. Unique Identifier : AIDSLINE MED/98022616; Legrand E; Pellegrin I; Neau D; Pellegrin JL; Ragnaud JM; Dupon M; Guillemain B; Fleury HJ; INSERM U328, Structure et Fonctions des Retrovirus Humains,; Laboratoire de Virologie de l'Universite Victor Segalen Bordeaux 2,; France.; Relationships were sought between specific anti-HIV cytotoxic T lymphocyte (CTL) responses (against structural and regulatory proteins of the HIV-1 LAI isolate) and plasma and cellular viral loads (VLs) in 17 recently HIV-1-infected patients including 3 displaying asymptomatic primary infection (PI) followed up for 12
Antiviral potency of drug-gene therapy combinations against human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1395-402. Unique Identifier : AIDSLINE MED/98022617; Junker U; Baker J; Kalfoglou CS; Veres G; Kaneshima H; Bohnlein E; Progenesys Program, Systemix Inc., Palo Alto, California 94304, USA.; ujunker@stem.com; Gene therapy for the treatment of human immunodeficiency virus type 1 (HIV-1) infection using intracellular immunization strategies is currently being tested in clinical trials. With the continuing development of potent antiretroviral drugs (e.g., reverse transcriptase [RT] and protease [PR] inhibitors), it is likely
Combination of a drug targeting the cell with a drug targeting the virus controls human immunodeficiency virus type 1 resistance.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1403-9. Unique Identifier : AIDSLINE MED/98022618; Lori F; Malykh AG; Foli A; Maserati R; De Antoni A; Minoli L; Padrini D; Degli Antoni A; Barchi E; Jessen H; Wainberg MA; Gallo RC; Lisziewicz J; Research Institute for Genetic and Human Therapy, Georgetown; University, Washington, DC 20007, USA.; Combinations of drugs targeting viral proteins have been used to limit or control drug resistance, which is the most important cause of treatment failure in HIV-1-infected individuals. We suggest an alternative approach, namely to target cellular proteins, which are less prone to mutations than viral proteins. Here we
Lymphocyte trafficking and HIV infection of human lymphoid tissue in a rotating wall vessel bioreactor.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1411-20. Unique Identifier : AIDSLINE MED/98022619; Margolis LB; Fitzgerald W; Glushakova S; Hatfill S; Amichay N; Baibakov B; Zimmerberg J; NASA/NIH Center for Three-Dimensional Tissue Cultures, Laboratory of; Cellular and Molecular Biophysics, National Institute of Child Health; and Human Development, National Institutes of Health, Bethesda,; Maryland 20892, USA. margolis@helix.nih.gov; The pathogenesis of HIV infection involves a complex interplay between both the infected and noninfected cells of human lymphoid tissue, the release of free viral particles, the de novo infection of cells, and the recirculatory trafficking of peripheral blood lymphocytes. To develop an in vitro model for studying thes
Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1421-8. Unique Identifier : AIDSLINE MED/98022620; Ishii N; Fukushima J; Kaneko T; Okada E; Tani K; Tanaka SI; Hamajima K; Xin KQ; Kawamoto S; Koff W; Nishioka K; Yasuda T; Okuda K; Department of Dermatology, Yokohama City University School of; Medicine, Yokohama, Japan.; Liposomes have been widely used to enhance the immune response. In the present investigation, we studied their in vivo immunomodulation of an HIV-1-specific DNA vaccine candidate pCMV160/REV) constructed with the cytomegalovirus (CMV) promoter-conjugated HIV-1 env and rev DNA plasm
Transcriptional activation of the intercellular adhesion molecule 1 (CD54) gene by human T lymphotropic virus types I and II Tax is mediated through a palindromic response element.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1429-37. Unique Identifier : AIDSLINE MED/98022621; Owen SM; Rudolph DL; Dezzutti CS; Shibata N; Naik S; Caughman SW; Lal RB; Retrovirus Diseases Branch, Division of AIDS, STD, and TB Laboratory; Research, Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; In vitro infection of T cells with human T lymphotropic virus types I and II (HTLV-I and HTLV-II) resulted in constitutive expression of ICAM-1. Higher levels of ICAM-1 mRNA were expressed in HTLV-transformed cell lines (MT-2, MoT, C8166) when compared with uninfected T cell lines (A301). We demonstrate that this acti
Diversity of full-length subtype E HIV type 1 env sequences in early seroconvertors from northern Thailand.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1439-41. Unique Identifier : AIDSLINE MED/98022622; Yu XF; Wang Z; Beyrer C; Celentano DD; Khamboonruang C; Nelson K; Department of Molecular Microbiology and Immunology, Johns Hopkins; University School of Hygiene and Public Health, Baltimore, Maryland; 21205, USA.
HIV type 1 envelope sequences from seroconverting patients in Barbados.: AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1443-6. Unique Identifier : AIDSLINE MED/98022623; Roth WW; Levett PN; Hudson CP; Roach TC; Womack C; Bond VC; Department of Biochemistry, Morehouse School of Medicine, Atlanta,; Georgia 30310, USA.
Gay youth and their precautionary sexual behaviors: the Sydney men and sexual health study.: AIDS Educ Prev. 1997 Oct;9(5):395-410. Unique Identifier : AIDSLINE MED/98053144; Van de Ven P; Noble J; Kippax S; Prestage G; Crawford J; Baxter D; Cooper D; National Centre in HIV Social Research, School of Behavioural; Sciences, Macquarie University, Sydney, NSW, Australia.; Many commentators have positioned Western gay youth as a high-risk group for HIV infection and obscured important cultural, social, and contextual differences between populations. This study compares risk of HIV transmission factors among 216 young (under 25 years) and 822 older (25 years or over) homosexually active
Condom use by Dutch men with commercial heterosexual contacts: determinants and considerations.: AIDS Educ Prev. 1997 Oct;9(5):411-23. Unique Identifier : AIDSLINE MED/98053145; de Graaf R; van Zessen G; Vanwesenbeeck I; Straver CJ; Visser JH; The Netherlands Institute of Mental Health and Addiction; Trimbos-instituut), Utrecht, The Netherlands.; We report responses from 559 clients of female prostitutes, with a view to determining to what extent previously identified factors play a part in condom use. To increase the response rate to advertisements in daily and weekly newspapers, interviews were held by phone. This procedure had the advantage of ensuring the
Attitudes, norms, self-efficacy, and stage of change among out-of-treatment female crack cocaine users: a pilot study.: AIDS Educ Prev. 1997 Oct;9(5):424-41. Unique Identifier : AIDSLINE MED/98053146; Montoya ID; Our Lady of the Lake University, Houston, TX 77027-6022, USA.; ASC@Phoenix.Net; The level of sexual risk among crack cocaine uses had remained high, regardless of their level of AIDS knowledge. Consequently, researchers have advocated the use of rigorous behavioral theory in aiding epidemiological research and intervention. To test whether stage of change for insisting that men (besides your mai
Psychosocial antecedents of needle/syringe disinfection by drug users: a theory-based prospective analysis.: AIDS Educ Prev. 1997 Oct;9(5):442-59. Unique Identifier : AIDSLINE MED/98053147; Longshore D; Stein JA; Anglin MD; Drug Abuse Research Center, University of California at Los Angeles; 90024, USA.; Working from the AIDS risk reduction model and other theories of behavior change, we tested psychosocial antecedents of needle/syringe disinfection by 136 injection drug users. High perceived self-efficacy for risk reduction exerted a positive effect on needles/syringe disinfection attempts 1 year later. Self-efficacy
AIDS knowledge and risk perception of cocaine and crack users in a national household survey.: AIDS Educ Prev. 1997 Oct;9(5):460-71. Unique Identifier : AIDSLINE MED/98053148; Silbersiepe KA; Hardy AM; Centers for Disease Control, National Center for Health Statistics,; Division of Health Interview Statistics, Hyattsville, MD 20782, USA.; Awareness of AIDS among cocaine and crack users has never been studied using national data representative of the U.S. household population. Data from the 1991 National Health Interview Survey were analyzed. Respondents who reported cocaine (n = 448) or crack use (n = 100) in the past year were compared with those who
AIDS and condoms in Brasilia: a telephone survey.: AIDS Educ Prev. 1997 Oct;9(5):472-84. Unique Identifier : AIDSLINE MED/98053149; Chequer P; VanOss Marin B; Paiva L; Hudes ES; Piazza T; Rodrigues L; Hearst N; National Coordination of STD/AIDS, Ministry of Health, Brasilia.; A telephone survey was conducted to measure AIDS knowledge, media usage and condom attitudes and behaviors among 500 adults aged 18 to 49 in Brasilia, as well as to evaluate the feasibility of the telephone survey method in a developing country. The response rate was 91.6%. Respondents had good knowledge about correct
Global AIDS surveillance--part I.: Wkly Epidemiol Rec. 1997 Nov 28;72(48):357-8. Unique Identifier : AIDSLINE MED/98073650
The current global situation of the HIV/AIDS pandemic.: Wkly Epidemiol Rec. 1997 Nov 28;72(48):359-60. Unique Identifier : AIDSLINE MED/98073651
Silver aids healing in the sterile skin wound: experimental studies in the laboratory rat.: Br J Dermatol. 1997 Nov;137(5):728-35. Unique Identifier : AIDSLINE MED/98076940; Lansdown AB; Sampson B; Laupattarakasem P; Vuttivirojana A; Department of Comparative Biology, Charing Cross and Westminster; Medical School, London, U.K.; Incisional wounds 15 mm long were induced surgically in the back skin of young adult Wistar rats. They were sutured and used as an experimental model in the therapeutic evaluation of daily applications of 0.5 mL of silver nitrate (SN) at 0.01, 0.1 or 1.0% w/v aqueous solution, or 0.5 g silver sulphadiazine (SSD) over
Destructive herpetic whitlow in AIDS: report of three cases.: Br J Dermatol. 1997 Nov;137(5):812-5. Unique Identifier : AIDSLINE MED/98076956; Robayna MG; Herranz P; Rubio FA; Pena P; Pena JM; Gonzalez J; Casado M; Department of Dermatology, La Paz Universitary Hospital, Autonoma; University, Madrid, Spain.; Herpes simplex virus infection in immunocompromised individuals, including AIDS patients, is characterized by its tendency for atypical presentations and unusual locations, often resulting in delayed diagnosis and treatment. Three HIV-infected patients who developed prolonged cutaneous lesions of the fingers are prese
Structure of a novel phosphocholine-containing aminoglycoglycerolipid of Mycoplasma fermentans.: Biochim Biophys Acta. 1997 Nov 8;1349(1):1-12. Unique Identifier : AIDSLINE MED/98081544; Matsuda K; Ishizuka I; Kasama T; Handa S; Yamamoto N; Taki T; Department of Microbiology, Tokyo Medical and Dental University,; Japan. kmats90820@aol.com; Mycoplasma fermentans is thought to be a pathogen of rheumatoid arthritis or a cofactor of AIDS (acquired immunodeficiency syndrome). To elucidate the possible involvement of membrane constituents in the pathogenesis of these diseases, we studied its lipid components. Several alkali labile glycophospholipids were dete
Effect of phospholipids on adsorption and penetration of human T-cell leukemia virus type I.: Biochim Biophys Acta. 1997 Nov 8;1349(1):25-32. Unique Identifier : AIDSLINE MED/98081546; Yang D; Iwai H; Yamamoto A; Fu D; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Maebashi, Japan. dwyang@dentb.hal.kagoshima-u.ac.jp; We have studied the ability of some phospholipids (PLs) and phospholipases (PLases) to interfere with infection of human T-cell leukemia virus type I (HTLV-I). Plating of pseudotype of vesicular stomatitis virus (VSV) bearing envelope antigens of HTLV-I, VSV(HTLV-I), was markedly inhibited by treatment of the cells wi
Alteration of T-cell subsets in the lymph nodes from cats infected with feline immunodeficiency virus.: J Vet Med Sci. 1997 Sep;59(9):739-46. Unique Identifier : AIDSLINE MED/98002087; Endo Y; Matsumura S; Washizu T; Ishida T; Department of Veterinary Internal Medicine, Graduate School of; Agricultural and Life Sciences, University of Tokyo, Japan.; Alterations of T-cell subsets in the lymph nodes from FIV-infected cats in various clinical disease stages were examined histologically. In the early stage of infection (AP stage), follicular hyperplasia accompanied by expansion of the paracortical area was observed. Follicular involution and depletion with reduced pa
Quantitative measurement of antibody inhibiting reverse transcriptase activity in cats naturally infected with feline immunodeficiency virus.: J Vet Med Sci. 1997 Sep;59(9):841-3. Unique Identifier : AIDSLINE MED/98002106; Saito T; Suzuki K; Imai M; Inaba Y; Department of Virology, Kanagawa Prefectural Public Health Laboratory,; Yokohama, Japan.; Quantitative measurement of reverse transcriptase-inhibiting RTI) antibodies in Japanese household cats naturally infected with feline immunodeficiency virus (FIV) was performed by poly A-linked colorimetric reverse transcriptase assay (PAC-RTA). Eight FIV-seropositive plasma samples were diluted twofold from 1:10 to
Extracorporeal whole body hyperthermia treatments for HIV infection and AIDS.: ASAIO J. 1997 Sep-Oct;43(5):M830-8. Unique Identifier : AIDSLINE MED/98024480; Ash SR; Steinhart CR; Curfman MF; Gingrich CH; Sapir DA; Ash EL; Fausset JM; Yatvin MB; HemoCleanse Inc., West Lafayette, Indiana 47906, USA.; Whole body hyperthermia therapy (WBHT) is the elevation of the core body temperature to 42 degrees C. In vitro studies have confirmed that 42 degrees C is cytocidal for virally infected lymphocytes, and even more effective when heating is repeated 4 days later. The safety and efficacy of two successive sessions of WBH
Usefulness of chest physiotherapy with positive expiratory pressure (PEP)-mask in HIV-infected children with recurrent pulmonary infections.: Acta Paediatr. 1997 Nov;86(11):1195-7. Unique Identifier : AIDSLINE MED/98065034; Plebani A; Pinzani R; Startari R; Brusa D; Padoan R; Department of Paediatrics G. e D. De Marchi, University of Milan,; Italy.; Eight children with human immunodeficiency virus (HIV) and recurrent bacterial pulmonary infections were treated using a Positive Expiratory Pressure (PEP)-mask twice a day for 12 months. At the end of the study, a reduction in the number of pulmonary infections [mean (SD) 2.1 (0.9) vs 4.5 (1) p
[Pars plana implantation of a ganciclovir drug carrier in patients with cytomegalovirus retinitis and AIDS. Indications, follow-up and postoperative complications]: Ophthalmologe. 1997 Oct;94(10):713-8. Unique Identifier : AIDSLINE MED/98027495; Gumbel H; Rosenkranz C; Schnaudigel OE; Mauck K; Fries U; Ohrloff C; Abteilung Allgemeine Augenheilkunde, Johann Wolfgang; Goethe-Universitat Frankfurt am Main.; We performed an open clinical trial to assess the safety and efficacy of a 1 microgram/h ganciclovir implant for the treatment of newly and pretreated cytomegalovirus ( CMV ) retinitis in patients with the acquired immunodefici
[Local therapy in treatment of cytomegalovirus (CMV) retinitis in AIDS. The ganciclovir implant (pellet)]: Ophthalmologe. 1997 Oct;94(10):719-23. Unique Identifier : AIDSLINE MED/98027496; Fuchs AV; Schneider A; Schweykart N; Klauss V; Kampik A; Augenklinik, Klinikum Innenstadt, Ludwig-Maximilians-Universitat; Munchen.; BACKGROUND: Cytomegalovirus ( CMV ) retinitis with AIDS has been treated either systemically or locally by weekly intravitreous injections. An intraocular device now offers a new therapeutic approach. We investigated its efficacy in preventing progression of CMV r
Canada re-examines its AIDS and HIV programmes [news]: BMJ. 1997 Nov 29;315(7120):1400. Unique Identifier : AIDSLINE MED/98079279; Spurgeon D
Death rate from HIV infection rises in Bombay [news]: BMJ. 1997 Nov 29;315(7120):1400. Unique Identifier : AIDSLINE MED/98079280; Mudur G
ABC of palliative care. HIV infection and AIDS.: BMJ. 1997 Nov 29;315(7120):1433-6. Unique Identifier : AIDSLINE MED/98079289; Wood CG; Whittet S; Bradbeer CS
Death of Diana, Princess of Wales. People experiencing emotional difficulties react in different ways [letter]: BMJ. 1997 Nov 29;315(7120):1467. Unique Identifier : AIDSLINE MED/98079312; Williams ER; Meadows J; Catalan J
HIV epidemic is far worse than thought [news]: BMJ. 1997 Dec 6;315(7121):1486. Unique Identifier : AIDSLINE MED/98082055; Wise J
Researchers' offices raided over banned AIDS drug [news]: BMJ. 1997 Dec 6;315(7121):1486. Unique Identifier : AIDSLINE MED/98082056; Sidley P
Antiretroviral combinations do not eliminate HIV entirely [news]: BMJ. 1997 Dec 6;315(7121):1488. Unique Identifier : AIDSLINE MED/98082057; Josefson D
Variation in incidences of tuberculosis in subgroups of South African gold miners.: Occup Environ Med. 1997 Sep;54(9):636-41. Unique Identifier : AIDSLINE MED/98085633; Kleinschmidt I; Churchyard G; Epidemiology Research Unit, Braamfontein, South Africa.; OBJECTIVES: To determine risk factors and to identify groups at high risk of tuberculosis (TB) among South African gold miners. METHODS: A retrospective cohort analysis was carried out with hospital and personnel databases on a random sample of the workforce of Freegold Mines, served by Ernest Oppenheimer Hospital, We
Development of a suicide gene as a novel approach to killing Mycobacterium tuberculosis.: Am J Respir Crit Care Med. 1997 Dec;156(6):1993-8. Unique Identifier : AIDSLINE MED/98074061; Rom WN; Yie TA; Tchou-Wong KM; Department of Medicine, New York University Medical Center, New York; City 10016, USA.; The increase in multidrug-resistant tuberculosis and high mortality among those co-infected with HIV-1 necessitates new therapeutic approaches directed at Mycobacterium tuberculosis. We hypothesized that a dominant-negative mutation in the DNA-dependent RNA polymerase gene would inhibit transcription of all genes by b
Multiple myeloma and Kaposi's sarcoma-associated herpesvirus--a paracrine model of tumorigenesis?: Trends Microbiol. 1997 Nov;5(11):424-5; discussion 425-6. Unique Identifier : AIDSLINE MED/98066314; Szekely L; Klein G; Microbiology and Tumor Biology Center (MTC), Karolinska Institute,; Stockholm, Sweden.
Treatment adequacy for HIV-related pneumocystis pneumonia: quality measures for inpatient care.: Int J Qual Health Care. 1997 Oct;9(5):349-59. Unique Identifier : AIDSLINE MED/98056042; Mathews WC; Kanouse DE; University of California, San Diego Department of Medicine, UCSD; Medical Center 92103-8681, USA.; To develop and evaluate severity-adjusted indicators of treatment timeliness and adequacy for inpatient care of first episode of HIV-related pneumocystis pneumonia, a retrospective cohort study n = 414) using medical record review was conducted in six California medical centers (1 January 1983-30 June 1987). Measures
[Developments in palliative care on ward b2 West; internal medicine, oncology and AIDS]: Oncologica. 1997 Feb;14(1):28-31. Unique Identifier : AIDSLINE MED/98079761; Kroeze GJ; Afdeling B2 west, Academisch Ziekenhuis Utrecht.
Acquired immune deficiency syndrome-related intussusception in adults.: Br J Surg. 1997 Nov;84(11):1539-40. Unique Identifier : AIDSLINE MED/98054983; Visvanathan R; Nichols TT; Reznek RH; Professorial Surgical Unit, St. Bartholomew's Hospital, West; Smithfield, London, UK.
The role of Th1 and Th2 dichotomy: implications for autoimmunity.: Rev Rhum Engl Ed. 1997 Oct 15;64(10 Suppl):131S-137S. Unique Identifier : AIDSLINE MED/98046771; Rocken M; Biedermann T; Ogilvie A; Dermatologische Klinik und Poliklinik der LMU, Munche, Germany.
The role of the Th1 and Th2 dichotomy in the pathogenesis of juvenile chronic arthritis.: Rev Rhum Engl Ed. 1997 Oct 15;64(10 Suppl):138S-139S. Unique Identifier : AIDSLINE MED/98046772; Miossec P; Clinical Immunology Unit, Edouard-Herriot Hospital, Lyon, France.; miossec@cimac-res.univ-lyon1.fr
HIV-1 envelope glycoprotein 120 regulates brain IL-1beta system and TNF-alpha mRNAs in vivo.: Brain Res Bull. 1997;44(1):67-73. Unique Identifier : AIDSLINE MED/97433163; Ilyin SE; Plata-Salaman CR; Division of Molecular Biology, School of Life and Health Sciences,; University of Delaware, Newark 19716-2590, USA.; Human immunodeficiency virus type I (HIV-1)-derived envelope glycoprotein 120 (gp120) is proposed to play an important role in HIV-1 neuropathology. Gp120 may act through mediators including proinflammatory cytokines. Here, we investigated the regulation of the IL-1beta system [IL-1beta, IL-1 receptor type I (IL-1RI),
Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on rhesus macaque monkeys chronically infected with simian immunodeficiency virus (SIVmac239).: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):313-7. Unique Identifier : AIDSLINE MED/98080496; Fujii Y; Mukai R; Mori K; Akari H; Otani I; Ono F; Kojima E; Takasaka M; Machida M; Murakami K; Yoshikawa Y; Iwakuni Research Laboratory, Nippon Paper Industries Company, Limited,; Japan.; To assess the therapeutic effects of 6-chloro-2 ,3 -dideoxyguanosine (6-Cl-ddG), a lipophilic dideoxynucleoside analogue, three rhesus macaques chronically infected with simian immunodeficiency virus (SIVmac239) were subcutaneously administered 25 mg/kg of the drug every 8 hours for 2 weeks. In two of three animals, t
Patterns of T-cell repopulation, virus load reduction, and restoration of T-cell function in HIV-infected persons during therapy with different antiretroviral agents.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):318-26. Unique Identifier : AIDSLINE MED/98080497; Pakker NG; Roos MT; van Leeuwen R; de Jong MD; Koot M; Reiss P; Lange JM; Miedema F; Danner SA; Schellekens PT; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service, Amsterdam.; The effect of antiretroviral therapy on both T-cell numbers and T-cell function in peripheral blood was studied. CD4+ and CD8+ T-cell numbers, T-cell reactivity to CD3 monoclonal antibodies mAb), and viral RNA load date were obtained from patients treated for at least 28 weeks with either the HIV-1 protease inhibitor
Rate of decline of percentage CD4+ cells is faster in HIV-1 than in HIV-2 infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):327-32. Unique Identifier : AIDSLINE MED/98080498; Jaffar S; Wilkins A; Ngom PT; Sabally S; Corrah T; Bangali JE; Rolfe M; Whittle HC; Medical Research Council Laboratories, Fajara, The Gambia.; Increasing evidence suggests that the pathogenesis of HIV-1 is different from that of HIV-2. Thus, we have measured, longitudinally at various times over a median follow-up of 2.1 years, the percentage CD4+ cells of 94 patients infected with HIV-1 and 164 patients infected with HIV-2. The pattern of decline of CD4% ov
Abnormal predominance of IgG in HIV-specific antibodies produced by short-term cultured duodenal biopsy specimens from HIV-infected patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):333-9. Unique Identifier : AIDSLINE MED/98080499; Schneider T; Zippel T; Schmidt W; Pauli G; Heise W; Wahnschaffe U; Riecken EO; Zeitz M; Ullrich R; Department of Gastroenterology, Medical Clinic, Universitatsklinikum; Benjamin Franklin, Free University of Berlin, Germany.; The aim of our study was to analyze HIV-specific humoral immunity in the intestinal mucosa at different stages of HIV infection in comparison with serum and saliva. Duodenal biopsy specimens from 30 AIDS patients and 9 HIV-infected patients without AIDS were cultured for 48 hours. Culture supernatants, as well as simu
Imbalance between IL-1 and IL-1 receptor antagonist in the cerebrospinal fluid of HIV-infected patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):340-2. Unique Identifier : AIDSLINE MED/98080500; Rimaniol AC; Zylberberg H; Rabian C; DeGroote D; Zavala F; Viard JP; Institut National de la Sante et de la Recherche Medicale U25, Hopital; Necker, Paris, France.; Inflammatory cytokines (interleukin [IL]-1 and tumor necrosis factor [TNF]) have specific inhibitors (IL-1 receptor antagonist [IL-1Ra] and TNF-soluble receptors), the concentration of which can indicate activation and regulation of this system. We measured IL-1 and IL-1Ra in the cerebrospinal fluid (CSF) of HIV-infec
Clinical predictors of declines in physical functioning in persons with AIDS: results of a longitudinal study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):343-9. Unique Identifier : AIDSLINE MED/98080501; Wilson IB; Cleary PD; Department of Health Care Policy, Harvard Medical School, Boston,; Massachusetts 02115, USA.; OBJECTIVE: This study was performed in an attempt to determine clinical correlates of declines in physical functioning in people with AIDS. DESIGN: An 8-month longitudinal cohort study was performed at three sites in Boston, Massachusetts: a private academic group practice, an AIDS clinic at a public teaching hospital
Disease-related factors associated with health-related quality of life in people with nonadvanced HIV disease assessed using an Italian version of the MOS-HIV Health Survey.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):350-6. Unique Identifier : AIDSLINE MED/98080502; Murri R; Ammassari A; Fantoni M; Scoppettuolo G; Cingolani A; De Luca A; Damiano F; Antinori A; Department of Infectious Diseases, Catholic University of Rome, Italy.; OBJECTIVE: This study was intended to present evidence for the reliability and validity of an Italian version of the MOS-HIV Health Survey and to identify important disease-related factors associated with health-related quality of life (HRQoL) in people with nonadvanced HIV. DESIGN: In this cross-sectional study, HRQo
Immunologic profiles of HIV-infected and uninfected commercial sex workers in the Vellore region of Southern India.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):357-61. Unique Identifier : AIDSLINE MED/98080503; Babu PG; Pramilabai A; Sripriya G; Damodharan S; John TJ; Retrovirus Laboratory, Department of Clinical Virology, Christian; Medical College Hospital, Vellore, India.; Female commercial sex workers (CSW) play a major role in the transmission of HIV infection in India . Their immunology has not been characterized. To determine HIV-related immunologic changes and establish baseline data for CSW, blood cell counts and serum immunoglobulin levels of 35
Improved AIDS surveillance through laboratory-initiated CD4 cell count reporting.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):362-6. Unique Identifier : AIDSLINE MED/98080504; McAnulty JM; Modesitt SK; Yusem SH; Hyer CJ; Fleming DW; Oregon Health Division, Center for Disease Prevention and; Epidemiology, Portland 97232, USA.; OBJECTIVE: To evaluate laboratory-initiated CD4 reporting (LICR) for AIDS surveillance and for differences in cases found by LICR and traditional surveillance methods (i.e., health care provider or death certificate reports and medical record searches). METHODS: We compared the characteristics of persons reported with
Clinical and epidemiologic features of a massive waterborne outbreak of cryptosporidiosis in persons with HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):367-73. Unique Identifier : AIDSLINE MED/98080505; Frisby HR; Addiss DG; Reiser WJ; Hancock B; Vergeront JM; Hoxie NJ; Davis JP; Bureau of Public Health, Wisconsin Division of Health, Madison; 53703-3044, USA.; During March and April 1993, a massive outbreak of Cryptosporidium infection resulted from contamination of the public water supply in Milwaukee, Wisconsin. The health impact of this outbreak in HIV-infected persons was unknown but was perceived as severe. We surveyed HIV-infected persons who resided in the greater Mi
Recent trends in the HIV epidemic in adolescent and young adult gay and bisexual men.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):374-9. Unique Identifier : AIDSLINE MED/98080506; Denning PH; Jones JL; Ward JW; Division of HIV/AIDS Prevention, National Center for HIV, STD, and TB; Prevention, Centers for Disease Control and Prevention, Atlanta,; Georgia 30333, USA. pbd0@cdc.gov; To explore recent patterns in the HIV epidemic in young gay and bisexual men, we analyzed national AIDS surveillance data for men who have sex with men (MSM) 13 to 25 years of age. Estimates of annual AIDS incidence were calculated by adjusting the surveillance data for reporting delays, unreported HIV risks, and the
Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):380-92. Unique Identifier : AIDSLINE MED/98080507; Kira J; Yamasaki K; Yamamoto I; Mizusawa H; Yoshino S; Kusunoki S; Yoshida T; Koyanagi Y; Tanaka Y; Kawano Y; Nakamura M; Tsuneyoshi M; Yamamoto N; Kobayashi T; Department of Neurology, Kyushu University, Fukuoka, Japan.; kira@neuro.med.kyushu-u.ac.jp; To compare the pathogenicity of HTLV-I derived from patients with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis TSP) and that from patients with adult T-cell leukemia (ATL), neonatal WKA rats were inoculated with either an HTLV-I-infected T-cell line (Fuk line) newly established from a HAM/TSP patien
"Why I am not infected with HIV": implications for long-term HIV risk reduction and HIV vaccine trials.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):393-9. Unique Identifier : AIDSLINE MED/98080508; Des Jarlais DC; Vanichseni S; Marmor M; Buavirat A; Titus S; Raktham S; Friedmann P; Kitayaporn D; Wolfe H; Friedman SR; Mastro TD; Chemical Dependency Institute, Beth Israel Medical Center, New York,; New York 10013, USA.; OBJECTIVE: To describe beliefs about remaining HIV-seronegative in injecting drug users in two high-seroprevalence cities, and to consider implications of these beliefs for ongoing risk reduction efforts and for HIV vaccine efficacy trials. DESIGN: Cross-sectional survey with open- and closed-ended questions. SUBJECTS
Reductions in high-risk drug use behaviors among participants in the Baltimore needle exchange program.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):400-6. Unique Identifier : AIDSLINE MED/98080509; Vlahov D; Junge B; Brookmeyer R; Cohn S; Riley E; Armenian H; Beilenson P; Department of Epidemiology, The Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland 21205, USA.; OBJECTIVE: To determine whether enrollment in the Baltimore Needle Exchange Program (NEP) was associated with short-term reduction in risky injection practices. METHODS: Demographic information was collected on NEP participants upon enrollment. A systematic sample of enrollees was interviewed at program entry, 2 weeks
Diagnosing pediatric AIDS in resource-poor settings: heat-denatured p24 antigen, anti-HIV IgA, or both? [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):407-8. Unique Identifier : AIDSLINE MED/98080510; Koulinska I; Stakteas S; Vaz P; Barreto J
Simplified procedures for enumeration of CD4+ T lymphocytes and quantification of HIV RNA [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):408. Unique Identifier : AIDSLINE MED/98080511; Arya SC
Hepatitis C and HIV in male prisoners [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):408-9. Unique Identifier : AIDSLINE MED/98080512; Rich JD; Chin-Hong PV; Busi KA; Mayer KH; Flanigan TP
Long-term nonprogression in HIV infection. Clinical Epidemiology Group from the Centre d'Information et de Soins de l'Immunodeficience Humaine [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 15;16(5):409-11. Unique Identifier : AIDSLINE MED/98080513; Salhi Y; Costagliola D
Predictors of postextraction complications in HIV-positive patients.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Nov;84(5):474-9. Unique Identifier : AIDSLINE MED/98056222; Dodson TB; Emory University School of Medicine, Atlanta, Ga., USA.; OBJECTIVE: The purpose of this study was to identify factors associated with an increased risk for post-tooth-extraction complications in a sample of HIV-positive patients. STUDY DESIGN: A cohort of HIV-positive patients who required the extraction of one or more teeth was enrolled. The predictor variables were groupe
Aberrant, noninfectious HIV-1 particles are released by chronically infected human T cells transduced with a retroviral vector expressing an interfering HIV-1 variant.: Gene Ther. 1997 Oct;4(10):1085-92. Unique Identifier : AIDSLINE MED/98077023; Bona R; d'Aloja P; Olivetta E; Modesti A; Modica A; Geraci A; Ferrari G; Verani P; Federico M; Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.; The expression of the nonproducer F12-HIV-1 genome has been previously shown to protect the host cell from HIV superinfection. In order to estimate the efficacy of the F12-HIV genome as an anti-HIV reagent also in cells already infected, an HIV-1 chronically infected Hut-78 cell clone (D10) was superinfected with an a
Urban low-income African American men, HIV/AIDS, and gender identity.: Med Anthropol Q. 1997 Dec;11(4):411-47. Unique Identifier : AIDSLINE MED/98073215; Whitehead TL; Department of Anthropology, University of Maryland, USA.; In a 1993 Human Organization article, Jerome Wright called for more research on African American male sexual behavior and the risk for HIV infection. The present article is a response to that call. Wright pointed out a well-known fact of HIV/AIDS prevention programs: such programs have not been very successful in reac
Gender, sexuality, and health in a turn-of-the-century "black metropolis".: Med Anthropol Q. 1997 Dec;11(4):448-53. Unique Identifier : AIDSLINE MED/98073216; Harrison FV; Department of Anthropology and Women's Studies Program, University of; South Carolina, Columbia, USA.
African American males and HIV: the challenge of the AIDS epidemic.: Med Anthropol Q. 1997 Dec;11(4):454-5. Unique Identifier : AIDSLINE MED/98073217; Wright J; Department of Social Work, Savannah State University, USA.
Signifying the pandemics: metaphors of AIDS, cancer, and heart disease.: Med Anthropol Q. 1997 Dec;11(4):456-76. Unique Identifier : AIDSLINE MED/98073218; Weiss M; Department of Sociology and Anthropology, Hebrew University of; Jerusalem.; This article offers a symbolic analysis of the cultural construction and signification of three of the major pandemics of the late 20th century: AIDS, cancer, and heart disease. It is based on unstructured interviews conducted in Israel between 1993-94 with 75 nurses and 40 physi
Conjuring medical science: the 1986 referendum on AIDS/HIV policy in California.: Med Anthropol Q. 1997 Dec;11(4):477-97. Unique Identifier : AIDSLINE MED/98073219; Toumey CP; Department of Anthropology, University of Kentucky, USA.; Medical science occupies a peculiar status in American life. On the one hand, people often view medical science as a privileged and authoritative body of knowledge that transcends other kinds of knowledge. On the other hand, medical-scientific authority can be easily conjured from the popular symbols of science, e.g.,
"You have to be your own doctor": sociocultural influences on alternative therapy use among gay men with AIDS in west Hollywood.: Med Anthropol Q. 1997 Dec;11(4):498-504. Unique Identifier : AIDSLINE MED/98073220; Furin JJ; Department of Social Medicine, Harvard Medical School, USA.; This article considers the use of alternative therapies by gay men with AIDS in West Hollywood, California. In all, 89 different alternative therapies for HIV and AIDS treatment were uncovered during the course of the study. In addition to the high number of alternative therapies, a majority of the men in the study (6
Speed, sex, gay men, and HIV: ecological and community perspectives.: Med Anthropol Q. 1997 Dec;11(4):505-15. Unique Identifier : AIDSLINE MED/98073221; Gorman EM; Barr BD; Hansen A; Robertson B; Green C; Alcohol and Drug Abuse Institute, University of Washington, USA.; Fifteen years into the HIV/AIDS epidemic, a great deal is now known about the different populations impacted by the disease, including those affected directly or indirectly by drug use. Anthropology has played a critical role in assisting with this task by identifying hidden populations, developing new methodological
Transforming growth factor-beta1 in adult human microglia and its stimulated production by interleukin-1.: J Interferon Cytokine Res. 1997 Nov;17(11):655-64. Unique Identifier : AIDSLINE MED/98063695; da Cunha A; Jefferson JJ; Tyor WR; Glass JD; Jannotta FS; Cottrell JR; Resau JH; Laboratory of Cell Biology, National Institute of Mental Health,; National Institutes of Health, Bethesda, MD, USA.; Ameboid microglia express human immunodeficiency virus 1 (HIV-1) more frequently than do ramified microglia. These two microglial subtypes might also differ in the frequency with which they express transforming growth factor-beta1 (TGF-beta1), a cytokine that regulates HIV-1 expression in monocytes. Results described
Importance of pretreatment viral load and monitoring of serum hepatitis C virus RNA in predicting responses to interferon-alpha2a treatment of chronic hepatitis C. Hanshin Chronic Hepatitis C Study Group.: J Interferon Cytokine Res. 1997 Nov;17(11):707-12. Unique Identifier : AIDSLINE MED/98063701; Wada M; Kang KB; Nishigami T; Shimoyama T; Fourth Department of Internal Medicine, Hyogo College of Medicine,; Nishinomiya, Japan.; The aim of this study was to determine what factors correlate with a favorable response to interferon-alpha2a (IFN-alpha2a) treatment in chronic hepatitis C. Fifty patients with chronic hepatitis C who received a 26-week treatment with IFN-alpha2a 474 million units in total) were assessed for pretreatment parameters a
Effects of RU486 on HIV-1 replication [letter]: Nat Med. 1997 Dec;3(12):1302-3. Unique Identifier : AIDSLINE MED/98057289; Soudeyns H; Wainberg MA
Black market drugs are only the tip of the iceberg [letter]: Nat Med. 1997 Dec;3(12):1303. Unique Identifier : AIDSLINE MED/98057290; Arya SC
UNAIDS expands HIV drug access in developing countries. Joint United Nations Programme on HIV/AIDS [news]: Nat Med. 1997 Dec;3(12):1307. Unique Identifier : AIDSLINE MED/98057294; Brower V
The multi-faceted personality of HIV [news; comment]: Nat Med. 1997 Dec;3(12):1318-20. Unique Identifier : AIDSLINE MED/98057302; Graziosi C; Pantaleo G
Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection [see comments]: Nat Med. 1997 Dec;3(12):1369-75. Unique Identifier : AIDSLINE MED/98057314; Zaitseva M; Blauvelt A; Lee S; Lapham CK; Klaus-Kovtun V; Mostowski H; Manischewitz J; Golding H; Division of Viral Products, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.; Transmission of HIV-1 is predominantly restricted to macrophage Mphi)-tropic strains. Langerhans cells (LCs) in mucosal epithelium, as well as macrophages located in the submucosal tissues, may be initial targets for HIV-1. This study was designed to determine whether restricted transmission of HIV-1 correlates with e
Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1.: Nat Med. 1997 Dec;3(12):1389-93. Unique Identifier : AIDSLINE MED/98057317; Gauduin MC; Parren PW; Weir R; Barbas CF; Burton DR; Koup RA; The Aaron Diamond AIDS Research Center, and The Rockefeller; University, New York, New York 10016, USA.; How well antibodies can protect against disease due to HIV-1 infection remains a pivotal but unresolved issue with important implications for vaccine design and the use of prophylactic antibody to prevent infection after accidental exposure to the virus and to interrupt transmission of virus from mother to child. Stro
[Effects of wound wet dressing with cerium nitrate on cell-mediated immunity after severe burn]: Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih. 1996 Jul;12(4):265-7. Unique Identifier : AIDSLINE MED/98048713; Fang Y; Chen Y; Wei D; Burn Center, Changhai Hospital, Second Military Medical University,; Shanghai.; Suppression of cell-mediated immunity (CM) and lowering of survival rate follow major thermal injury are associated with absorption of burn toxin. Wistar rats received 30% full-thickness burn, and were then treated with early burn excision or wet dressing of cerium nitrate for the wound. At day 14 postburn, both survi
[World AIDS Day--children in a world with AIDS]: Tidsskr Sykepl. 1997 Nov 11;85(19):42-3. Unique Identifier : AIDSLINE MED/98079796
[Antiviral immunodeficiency: EBV, CMV, adenovirus]: Hematol Cell Ther. 1997 Oct;39(5):269-73. Unique Identifier : AIDSLINE MED/98057675; Cavazzana-Calvo M; Durandy A; Le Deist F; INSERM U429, Hopital Necker-Enfants Malades, Paris, France.; Patients undergoing bone marrow transplantation are susceptible to many different bacterial, fungal and viral infections. Among the viral pathogens, cytomegalovirus ( CMV ), Epstein-Barr virus EBV), and adenovirus cause the gre
Functional maturation of mouse CD4+CD8- thymocytes induced by medullary-type thymus epithelial cells.: Sci China C Life Sci. 1996 Aug;39(4):427-39. Unique Identifier : AIDSLINE MED/98050223; Lu L; Chen W; Department of Immunology, Beijing Medical University, China.; Murine CD4+CD8-(CD4SP) thymocyte subset is a heterogeneous population, in which the Qa-2- cells are less functional, whereas the Qa-2+ cells are fully functional. Evidence is provided here that the transition from Qa-2- to Qa-2+ CD4SP thymocytes is an intrathymic process of differentiation induced by thymic medullary-
HIV home tests [news]: Mol Med Today. 1995 Jul;1(4):158. Unique Identifier : AIDSLINE MED/98092039; Harby K
Infectious diseases in the year of Louis Pasteur.: Mol Med Today. 1995 Jul;1(4):160-1. Unique Identifier : AIDSLINE MED/98076860; Digoutte JP; Hoosen AA; Institut Pasteur de Dakar, Senegal.
Cyclosporins: immunosuppressive drugs with anti-HIV-1 activity.: Mol Med Today. 1995 Sep;1(6):287-91. Unique Identifier : AIDSLINE MED/98076871; Thali M; Institute of Microbiology, University of Lausanne, Switzerland.; Markus.Thali.@inst.hospvd.ch; Cyclosporin A was introduced into clinical use in the late 1970s to reduce graft rejection after organ transplantation. This drug, a cyclic undecapeptide metabolite of the fungus Tolypocladium inflatum, interferes with lymphokine biosynthesis, hence its immunosuppressive activity. Recently, it has become clear that cy
Environmental antigens and atopic disease: underlying mechanisms and prospects for therapy and prophylaxis.: Mol Med Today. 1995 Sep;1(6):292-8. Unique Identifier : AIDSLINE MED/98076872; Holt PG; Natural exposure to non-pathogenic antigens, the so-called environmental antigens , experimentally elicits a characteristic pattern of T-cell immunity, involving selective suppression of the T-cell-dependent IgE responses that trigger allergic reactions. This immune deviation results in the generation of long-lived
NIH grant for Candida and AIDS research [news]: Mol Med Today. 1995 Oct;1(7):300. Unique Identifier : AIDSLINE MED/98076875; Holzman DC
Does differential neuroendocrine control of cytokine production govern the expression of autoimmune diseases in pregnancy and the postpartum period?: Mol Med Today. 1997 Sep;3(9):379-83. Unique Identifier : AIDSLINE MED/97448277; Elenkov IJ; Hoffman J; Wilder RL; Inflammatory Joint Diseases Section, National Institute of Arthritis; and Musculoskeletal and Skin Diseases, National Institutes of Health,; Bethesda, MD 20892, USA. elenkovl@cc1.nichd.nih.gov; Pregnancy and the postpartum period are associated with significant changes in levels of several hormones, such as estrogen, progesterone, cortisol and possibly catecholamines. Moreover, several autoimmune diseases such as rheumatoid arthritis tend to remit, develop or exacerbate during pregnancy or the postpartum per
Conformation of Tax-response elements in the human T-cell leukemia virus type I promoter.: Chem Biol. 1995 Dec;2(12):819-26. Unique Identifier : AIDSLINE MED/98044737; Cox JM; Sloan LS; Schepartz A; Department of Chemistry, Yale University, New Haven, CT 06520-8107,; USA.; BACKGROUND: HTLV-I Tax is believed to activate viral gene expression by binding bZIP proteins (such as CREB) and increasing their affinities for proviral TRE target sites. Each 21 bp TRE target site contains an imperfect copy of the intrinsically bent CRE target site (the TRE core) surrounded by highly conserved flank
Molecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex.: Chem Biol. 1995 Dec;2(12):827-40. Unique Identifier : AIDSLINE MED/98044738; Ye X; Kumar RA; Patel DJ; Cellular Biochemistry & Biophysics Program, Memorial Sloan-Kettering; Cancer Center, New York, NY 10021, USA.; BACKGROUND: In lentiviruses such as human immunodeficiency virus HIV) and bovine immunodeficiency virus (BIV), the Tat trans-activating) protein enhances transcription of the viral RNA by complexing to the 5 -end of the transcribed mRNA, at a region known as TAR (the trans-activation response element). Identification
Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming.: Chem Biol. 1995 May;2(5):317-24. Unique Identifier : AIDSLINE MED/98044681; Gehlhaar DK; Verkhivker GM; Rejto PA; Sherman CJ; Fogel DB; Fogel LJ; Freer ST; Agouron Pharmaceuticals, Inc., San Diego, CA 92121-1121, USA.; BACKGROUND: An important prerequisite for computational structure-based drug design is prediction of the structures of ligand-protein complexes that have not yet been experimentally determined by X-ray crystallography or NMR. For this task, docking of rigid ligands is inadequate because it assumes knowledge of the con
A novel RNA motif for neomycin recognition.: Chem Biol. 1995 Aug;2(8):543-52. Unique Identifier : AIDSLINE MED/98044706; Wallis MG; von Ahsen U; Schroeder R; Famulok M; Institut fur Mikrobiologie und Genetik, Universitat Wien, Austria.; BACKGROUND: Antibiotics can interfere with RNA activity. Translation of RNA by the prokaryotic ribosome, self-splicing of group I introns, HIV replication and hammerhead ribozyme cleavage are inhibited by the aminoglycoside neomycin B. To explore the molecular basis by which small molecules such as antibiotics inhibit
Clinical use of erythropoietin.: Curr Opin Hematol. 1995 Mar;2(2):118-24. Unique Identifier : AIDSLINE MED/98039250; Henry DH; Spivak JL; Graduate Hospital, Philadelphia, Pennsylvania, USA.; Recombinant human erythropoietin has been available for clinical use since 1985. It was an immediate success in treating the anemia of chronic renal failure and has also enjoyed some objective success in the treatment of other anemias in either a therapeutic or prophylactic setting, but the issues of appropriate patie
The use of hematopoietic growth factors in treating HIV infection.: Curr Opin Hematol. 1995 May;2(3):227-33. Unique Identifier : AIDSLINE MED/98039269; Miles S; University of California, Los Angeles, USA.; Human immunodeficiency virus infection causes multilineage hematopoietic defects. Defects in the production and function of CD4+ helper cells have been the focus of the majority of HIV research, but anemia, neutropenia, and thrombocytopenia are significant clinical problems as well. Bone marrow suppression is the dose
How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.: Cell. 1997 Dec 12;91(6):721-30. Unique Identifier : AIDSLINE MED/98074792; Dimitrov DS; Laboratory of Experimental and Computational Biology, DBS, NCI/FCRDC,; NIH, Frederick, Maryland 21702-1201, USA.
Molecular basis for the binding promiscuity of an anti-p24 HIV-1) monoclonal antibody.: Cell. 1997 Dec 12;91(6):799-809. Unique Identifier : AIDSLINE MED/98074800; Kramer A; Keitel T; Winkler K; Stocklein W; Hohne W; Schneider-Mergener J; Institut fur Medizinische Immunologie, Universitatsklinikum Charite,; Humboldt-Universitat zu Berlin, Germany.; Multiple binding capabilities utilized by specific protein-to-protein interactions in molecular recognition events are being documented increasingly but remain poorly understood at the molecular level. We identified five unrelated peptides that compete with each other for binding to the paratope region of the monoclon
Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity.: Cell. 1997 Dec 12;91(6):811-20. Unique Identifier : AIDSLINE MED/98074801; Keitel T; Kramer A; Wessner H; Scholz C; Schneider-Mergener J; Hohne W; Institut fur Biochemie, Universitatsklinikum Charite,; Humboldt-Universitat zu Berlin, Germany.; The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum re
AIDS rates increase among women during first half of 90s--greatest increase found to occur through heterosexual contact [news]: Int J Fertil Womens Med. 1997 Sep-Oct;42(5):276. Unique Identifier : AIDSLINE MED/98068664
Genes controlling retroviral virulence.: Adv Vet Med. 1997;40:135-55. Unique Identifier : AIDSLINE MED/98056845; Fuller FJ; Department of Microbiology, Pathology, and Parasitology, North; Carolina State University, College of Veterinary Medicine, Raleigh; 27606, USA.
Combinatorial tools for the analysis of transcriptional regulation.: Pac Symp Biocomput. 1997;:62-73. Unique Identifier : AIDSLINE MED/98051953; Bergeron A; Gaul E; Bergeron D; LACIM, Universite du Quebec a Montreal, Canada. anne@lacim.uqam.ca; In this paper, we discuss virtual experiments for the study of major regulatory processes such as translation, signalization or transcription pathways. An essential part of these processes is the formation of protein clusters held together by a small number of binding domains that can be shared by many different prote
Quantitative determination of CGP 61755, a protease inhibitor, in plasma and urine by high-performance liquid chromatography and fluorescence detection.: J Chromatogr B Biomed Sci Appl. 1997 Aug 15;696(1):123-30. Unique Identifier : AIDSLINE MED/97443640; Flesch G; Mann C; Degen PH; Ciba-Geigy, Pharmaceuticals Division, Basle, Switzerland.; A liquid chromatographic assay for the determination of CGP 61755 I) in plasma and urine is described. A similar method for CGP 53437, another HIV-1 protease inhibitor, has been developed and reported previously. After a deproteinization step, a liquid-liquid extraction is performed. Compound I and the internal standa
Cathepsin B-inhibitor promotes the development of Th1 type protective T cells in mice infected with Leishmania major.: J Med Invest. 1997 Aug;44(1-2):33-9. Unique Identifier : AIDSLINE MED/98055901; Maekawa Y; Himeno K; Katunuma N; Department of parasitology and Immunology, University of Tokushima; School of Medicine, Japan.; BALB/c mice are genetically susceptible to infection with Leishmania major (L major). When such mice infected with L. major were treated with specific inhibitors of cathepsin B, a lysosomal cysteine protease that digests exogenous antigenic proteins, the mice acquired resistance against L. major infection. T cells fro
Estimation of the impact of the human immunodeficiency virus infection on tuberculosis: tuberculosis risks re-visited?: Int J Tuberc Lung Dis. 1997 Jun;1(3):196-204. Unique Identifier : AIDSLINE MED/98059482; Lienhardt C; Rodrigues LC; London School of Hygiene and Tropical Medicine, UK.; The human immunodeficiency virus (HIV) infection has both a direct and an indirect effect on the incidence of tuberculosis. The direct effect is due to the increased number of cases among HIV-infected individuals because of their enhanced susceptibility to the disease. The indirect effect is increased transmission of
Impact of HIV on tuberculosis in sub-Saharan Africa: a regional perspective.: Int J Tuberc Lung Dis. 1997 Jun;1(3):205-14. Unique Identifier : AIDSLINE MED/98059483; Cantwell MF; Binkin NJ; Division of Tuberculosis Elimination, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; SETTING: The relative magnitude of the recent rise in tuberculosis (TB) in sub-Saharan Africa and the proportion of excess TB cases attributable to the human immunodeficiency virus HIV) have not been evaluated from a regional perspective. METHODS: For each of 10 countries in mainland sub-Saharan Africa, we used report
Human immunodeficiency virus-positive tuberculous lymphadenitis in Central Africa: clinical presentation of 157 cases.: Int J Tuberc Lung Dis. 1997 Jun;1(3):215-9. Unique Identifier : AIDSLINE MED/98059484; Bem C; Department of Surgery, School of Medicine, University of Zambia,; Lusaka, Zambia.; SETTING: University Teaching Hospital, Lusaka, Zambia . OBJECTIVE: To compare the clinical presentation of human immunodeficiency virus (HIV)-positive tuberculous lymphadenitis with primary HIV lymphadenopathy and HIV-negative tuberculous lymphadenitis. DESIGN: Prospective study of
A retrospective study of human immunodeficiency virus infection and drug-resistant tuberculosis in Durban, South Africa.: Int J Tuberc Lung Dis. 1997 Jun;1(3):220-4. Unique Identifier : AIDSLINE MED/98059485; Anastasis D; Pillai G; Rambiritch V; Abdool Karim SS; Department of Pharmacology, University of Durban-Westville, South; Africa.; SETTING: King George V hospital, a specialist referral hospital for tuberculosis (TB) patients in Durban, South Africa . OBJECTIVE: To investigate the relationship between drug-resistant TB and human immunodeficiency virus (HIV) infection. DESIGN: Retrospective descriptive study of
Tuberculosis in Lorraine, France: study of prognostic factors.: Int J Tuberc Lung Dis. 1997 Jun;1(3):246-9. Unique Identifier : AIDSLINE MED/98059489; Rabaud C; Engozogho M; Dailloux M; Hoen B; May T; Canton P; Service d'Hygiene Hospitaliere, CHU de Nancy, France.; AIM: To identify factors predicting short-term mortality in patients with tuberculosis in the Lorraine region of France . METHOD: Retrospective survey in nine voluntarily participating hospitals between January 1990 and December 1994. RESULTS: In total 351 files were analyzed. The a
Smear positive pulmonary tuberculosis in a prison setting: experience in the penal camp of Bouake, Ivory Coast.: Int J Tuberc Lung Dis. 1997 Jun;1(3):250-3. Unique Identifier : AIDSLINE MED/98059490; Koffi N; Ngom AK; Aka-Danguy E; Seka A; Akoto A; Fadiga D; Department of Pulmonology, CHU de Cocody, Abidjan.; SETTING: Bouake prison camp, Ivory Coast . OBJECTIVE: To determine the clinical, radiographic and therapeutic characteristics of smear-positive pulmonary tuberculosis in the prison camp of Bouake. METHODS: The study included 108 cases of smear positive pulmonary tuberculosis wh
Evaluation of the MycoDot test for the diagnosis of tuberculosis in HIV seropositive and seronegative patients.: Int J Tuberc Lung Dis. 1997 Jun;1(3):259-64. Unique Identifier : AIDSLINE MED/98059492; Ratanasuwan W; Kreiss JK; Nolan CM; Schaeffler BA; Suwanagool S; Tunsupasawasdikul S; Chuchottaworn C; Dejsomritrutai W; Foy HM; Department of Epidemiology, University of Washington, Seattle 98195,; USA.; SETTING: Patients were recruited from Siriraj, Bamrasnaradura, and Central Chest Hospitals, the three major hospitals responsible for tuberculosis patients in Bangkok, Thailand , and vicinity. OBJECTIVE: To evaluate a new rapid serologic test, the MycoDot test, for diagnosis of tu
Tuberculosis care in community care organizations in sub-Saharan Africa: practice and potential.: Int J Tuberc Lung Dis. 1997 Jun;1(3):276-83. Unique Identifier : AIDSLINE MED/98059495; Maher D; Hausler HP; Raviglione MC; Kaleeba N; Aisu T; Fourie B; Nunn P; Global Tuberculosis Programme, World Health Organization, Geneva,; Switzerland.; SETTING: Community care organizations in sub-Saharan Africa. OBJECTIVES: To evaluate current tuberculosis (TB) care in community health care organizations in sub-Saharan Africa, to assess their potential contribution to tuberculosis care, and to develop a model for expanded community participation in effective TB cont
Adrenal function and the hypothalamo-pituitary adrenal axis in immunodeficiency virus-associated tuberculosis [letter]: Int J Tuberc Lung Dis. 1997 Jun;1(3):289-90. Unique Identifier : AIDSLINE MED/98059497; Baker R; Rook GA; Zumla A
What's in a name ... TB or not TB? [letter]: Int J Tuberc Lung Dis. 1997 Jun;1(3):290-1. Unique Identifier : AIDSLINE MED/98059498; Grange JM
DOTS and beyond: towards a holistic approach to the conquest of tuberculosis [editorial]: Int J Tuberc Lung Dis. 1997 Aug;1(4):293-6. Unique Identifier : AIDSLINE MED/98059499; Grange JM
Multidrug-resistant tuberculosis: many paths, same truth [editorial; comment]: Int J Tuberc Lung Dis. 1997 Aug;1(4):297-8. Unique Identifier : AIDSLINE MED/98059500; Fujiwara PI; Sherman LF
Multidrug-resistant tuberculosis in Denmark 1993-1995 [see comments]: Int J Tuberc Lung Dis. 1997 Aug;1(4):299-301. Unique Identifier : AIDSLINE MED/98059501; Viskum K; Kok-Jensen A; Clinic of Pulmonary Medicine, RHIMA Center, University Hospital,; p4penhagen, Denmark.; SETTING: All bacteriologically confirmed new cases of tuberculosis and treatment relapses in Denmark are examined for drug resistance. In the years 1993-1995, nine cases of multidrug-resistant tuberculosis (MDR-TB), all acquired out
Drug-resistant tuberculosis in Korea, 1994 [see comments]: Int J Tuberc Lung Dis. 1997 Aug;1(4):302-8. Unique Identifier : AIDSLINE MED/98059502; Kim SJ; Bai GH; Hong YP; Korean Institute of Tuberculosis, Korean National Tuberculosis; Association, Seoul, Korea.; SETTING: Sample survey based on pulmonary tuberculosis (TB) patients registered in 264 health centres in Korea, compared with data obtained from nationwide TB prevalence surveys conducted since 1965. OBJECTIVE: To determine the level of antituberculosis drug resistance (DR) and to assess its impact on treatment outcom
Survey of primary drug resistance of Mycobacterium tuberculosis in Casablanca, Morocco.: Int J Tuberc Lung Dis. 1997 Aug;1(4):309-13. Unique Identifier : AIDSLINE MED/98059503; el Baghdadi J; Lazraq R; Ibrahimy S; Bouayad Z; Guinet R; Benslimane A; Unite des Mycobacteries, Institut Pasteur du Maroc, Casablanca.; SETTING: In 1990, a 6-month short-course regimen (2 SHRZ/4 RH) was introduced for the treatment of tuberculosis in Morocco . OBJECTIVE: To assess the efficacy of the national tuberculosis control programme, a prospective study of primary drug resistance was conducted from April 199
Risk factors and outcome of human immunodeficiency virus-infected patients with sporadic multidrug-resistant tuberculosis in New York City.: Int J Tuberc Lung Dis. 1997 Aug;1(4):319-25. Unique Identifier : AIDSLINE MED/98059505; Mannheimer SB; Sepkowitz KA; Stoeckle M; Friedman CR; Hafner A; Riley LW; Division of Infectious Diseases and International Medicine, Cornell; University Medical College, New York, NY, USA. sbm20@columbia.edu; SETTING: An 880 bed university teaching hospital in New York City. OBJECTIVE: To assess risk factors and outcome for sporadic cases of multidrug-resistant tuberculosis (MDR-TB) in persons with human immunodeficiency virus (HIV) infection. DESIGN: In a retrospective cohort analysis, 13 HIV-positive patients with MDR-TB
The pattern of tuberculosis in Queen Elizabeth Central Hospital, Blantyre, Malawi: 1986-1995.: Int J Tuberc Lung Dis. 1997 Aug;1(4):346-51. Unique Identifier : AIDSLINE MED/98059509; Harries AD; Parry C; Nyongonya Mbewe L; Graham SM; Daley HM; Maher D; Salaniponi FM; Nyangulu DS; Department of Medicine, College of Medicine, Chichiri, Blantyre,; Malawi.; SETTING: Queen Elizabeth Central Hospital (QECH), Blantyre, Malawi . OBJECTIVE: To determine the pattern of tuberculosis (TB) cases over a period of ten years. DESIGN: TB registers for QECH for the years 1986-1995 (January 1st to December 31st) were obtained and clinical information
Characteristics of tuberculosis patients who generate secondary cases.: Int J Tuberc Lung Dis. 1997 Aug;1(4):352-7. Unique Identifier : AIDSLINE MED/98059510; Rodrigo T; Cayla JA; Garcia de Olalla P; Galdos-Tanguis H; Jansa JM; Miranda P; Brugal T; Department of Epidemiology, Municipal Institute of Health, Barcelona,; Spain.; OBJECTIVE: To determine the characteristics of smear positive tuberculosis (TB) patients who generate secondary TB cases. METHODS: Those smear positive TB patients detected by the Barcelona Tuberculosis Program between 1990-1993, and for whom contact studies had been performed, were studied. We analyzed the predictive
Tuberculous pericardial effusion: a prospective clinical study in a low-resource setting--Blantyre, Malawi.: Int J Tuberc Lung Dis. 1997 Aug;1(4):358-64. Unique Identifier : AIDSLINE MED/98059511; Maher D; Harries AD; Global Tuberculosis Programme, World Health Organization, Geneva,; Switzerland. maherd@who.ch; SETTING: Queen Elizabeth Central Hospital, Blantyre, Malawi . OBJECTIVE: Review of clinical and investigation findings and outcome, using a standard management protocol, in human immunodeficiency virus (HIV)-positive and HIV-negative patients with tuberculous pericardial effusion, i
Restriction fragment length polymorphism study of Mycobacterium tuberculosis in Thailand using IS6110 as probe.: Int J Tuberc Lung Dis. 1997 Aug;1(4):370-6. Unique Identifier : AIDSLINE MED/98059513; Palittapongarnpim P; Luangsook P; Tansuphaswadikul S; Chuchottaworn C; Prachaktam R; Sathapatayavongs B; Department of Microbiology, Faculty of Science, Ramathibodi Hospital,; Mahidol University, Bangkok, Thailand.; SETTING: Three referral hospitals in central Thailand . OBJECTIVE: To determine the population structure of Mycobacterium tuberculosis isolated from the referral hospitals. DESIGN: Study of 211 isolates of the bacteria received from the hospitals in central Thailand by Southern hy
Wrong drug used for tuberculosis [letter]: Int J Tuberc Lung Dis. 1997 Aug;1(4):385. Unique Identifier : AIDSLINE MED/98059516; Kelly PM
The use of aromatherapy in hospitalized children with HIV disease.: Complement Ther Nurs Midwifery. 1997 Feb;3(1):16-20. Unique Identifier : AIDSLINE MED/98085419; Styles JL; Paediatric Unit, St Mary's Hospital, London, UK.; Aromatherapy has been defined as the art--and science--of using essential plant oils in treatments ... a truly holistic therapy, taking into account mind, body and spirit ... (Davis 1991). Aromatherapy is a valuable means of maintaining optimum health, particularly when the dis-ease of the body or mind is related to
Role of T cells in the pathogenesis of autoimmune lacrimal gland disease in MRL/Mp-lpr/lpr mice.: Curr Eye Res. 1997 Sep;16(9):909-16. Unique Identifier : AIDSLINE MED/97434566; Jabs DA; Lee B; Prendergast RA; Department of Ophthalmology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA.; PURPOSE: MRL/Mp-lpr/lpr mice (MRL/lpr) spontaneously develop an autoimmune disease, including lacrimal gland lesions, which are a model for Sjogren s syndrome. Target organ lesions in MRL/lpr mice are composed largely of CD4+ T cells, and treatment with monoclonal antibodies (mAb) against CD4 improves in the systemic
Tuberculous pericarditis and AIDS: case reports and review.: Eur J Epidemiol. 1997 Oct;13(7):755-9. Unique Identifier : AIDSLINE MED/98043919; Mastroianni A; Coronado O; Chiodo F; Istituto Malattie Infettive, Policlinico Sant'Orsola, Universita di; Bologna, Italy.; Pericarditis is one of the most common cardiac complications in the course of HIV disease. Opportunistic infections and neoplastic processes represent the most common etiology of pericardial disease. Pericardial tuberculosis is an uncommon condition, especially in developed countries. Two cases of tuberculous pericard
[Bartonella infections. Former infectious diseases return]: Fortschr Med. 1997 Sep 30;115(27):22, 24. Unique Identifier : AIDSLINE MED/98014016
[New attack point in anti-HIV therapy discovered. Docking of viruses to human cells can be prevented]: Fortschr Med. 1997 Sep 30;115(27):48-50. Unique Identifier : AIDSLINE MED/98014021; Baggiolini M; Theodor-Kocher-Institut der Universitat Bern.
[Immunological analysis of HTLV-I env-pX transgenic rat with various collagen vascular diseases]: Hokkaido Igaku Zasshi. 1997 Sep;72(5):529-44. Unique Identifier : AIDSLINE MED/98029896; Nakamaru Y; Department of Otorhinolaryngology, Hokkaido University School of; Medicine, Sapporo, Japan.; Human T lymphocyte virus type-I (HTLV-I) is an etiologic agent of not only adult T cell leukemia but also HTLV-I associated myelopathy/tropical spastic paraparesis, HTLV-I associated arthropathy and other immunological disorders, such as Sjogren syndrome, dermatitis, polymyositis, and uveitis. We recently reported tha
[Development of thymic tumor in HTLV-I transgenic rats under control of a lymphoid tissue specific promoter]: Hokkaido Igaku Zasshi. 1997 Sep;72(5):545-64. Unique Identifier : AIDSLINE MED/98029897; Kikuchi K; First Department of Pathology, Hokkaido University School of Medicine,; Sapporo, Japan.; The p40tax protein of Human T lymphocyte virus type I (HTLV-I) is known to be a transactivator not only for the own viral gene but also for the various cellular genes (host genes), including a number of cytokine genes and genes for cell proliferation. Its tumorigenicity was also reported in vivo, such as developments
Trends of HIV infection in the blood donors of Delhi.: Indian J Pathol Microbiol. 1996 Apr;39(2):139-42. Unique Identifier : AIDSLINE MED/98064511; Makroo RN; Salil P; Vashist RP; Shivlal; Department of Transfusion Medicine, Apollo Hospital, New Delhi.; Screening of HIV Infection was made mandatory for every unit of blood collected for transfusion in Delhi, India since 1989. Ten Zonal Blood Testing Centres have been identified which test all the blood collected for HIV by 29 blood blanks for the city. Reports from these testing cen
HIV risk behaviour in Irish intravenous drug users.: Ir J Med Sci. 1997 Oct-Dec;166(4):235-8. Unique Identifier : AIDSLINE MED/98055868; Dorman A; Keenan E; Schuttler C; Merry J; O'Connor JJ; Drug Treatment Centre Board, Dublin.; The aim of the study was to measure HIV prevalence and risk behaviour in 185 Irish Intravenous Drug Misusers. Information was obtained by application of a standardised WHO questionnaire covering HIV risk behaviour in the preceding 6 months. HIV serostatus was obtained by saliva/blood sample testing. One hundred and 3
Time compressed: psychoanalysis in the days of HIV and AIDS.: J Am Acad Psychoanal. 1997 Summer;25(2):277-93. Unique Identifier : AIDSLINE MED/98057769; Olsson PA; Monadnuck Family Services, Keene, N.H., USA.
Thermodynamic analysis of the interaction between the 0.5beta Fv fragment and the RP135 peptide antigen derived from the V3 loop of HIV-1 gp120.: J Biol Chem. 1997 Dec 12;272(50):31407-11. Unique Identifier : AIDSLINE MED/98058925; Faiman GA; Horovitz A; Department of Structural Biology, Weizmann Institute of Science,; Rehovot 76100, Israel.; The Fv fragment of the 0.5beta monoclonal antibody has recently been constructed, expressed, and purified. It binds with nanomolar affinity to the immunogenic RP135 peptide that is derived from the principal neutralizing determinant of HIV-1 in the third hypervariable region of gp120. Here, we analyzed the temperature
Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein.: J Cell Biol. 1997 Dec 15;139(6):1455-64. Unique Identifier : AIDSLINE MED/98060841; Hernandez LD; Peters RJ; Delos SE; Young JA; Agard DA; White JM; Department of Cell Biology, University of Virginia Health Sciences; Center, Charlottesville, Virginia 22908, USA.; It is not known how membrane fusion proteins that function at neutral pH, for example the human immunodeficiency virus envelope Env) glycoprotein and intracellular fusion machines, are activated for target bilayer binding. We have addressed this question using a soluble oligomeric form of an avian retroviral Env glyco
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.: J Clin Invest. 1997 Nov 15;100(10):2552-61. Unique Identifier : AIDSLINE MED/98063063; Boring L; Gosling J; Chensue SW; Kunkel SL; Farese RV Jr; Broxmeyer HE; Charo IF; Gladstone Institute of Cardiovascular Disease, University of; California, San Francisco 94141-9100, USA.; Monocyte chemoattractant protein-1 (MCP-1) is a potent agonist for mononuclear leukocytes and has been implicated in the pathogenesis of atherosclerosis and granulomatous lung disease. To determine the role of MCP-1 and related family members in vivo, we used homologous recombination in embryonic stem cells to generat
Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus.: J Clin Invest. 1997 Nov 15;100(10):2606-10. Unique Identifier : AIDSLINE MED/98063069; Kedes DH; Lagunoff M; Renne R; Ganem D; Department of Microbiology and Immunology, University of California; Medical Center, San Francisco 94143-0414, USA.; Over 85% of patients with Kaposi s sarcoma (KS) are seropositive for antibodies to the latency-associated nuclear antigen (LANA) expressed in B cell lines infected with Kaposi s sarcoma-associated herpesvirus (KSHV). The presence of antibodies to LANA strongly correlates with the risk of developing the disease. Howeve
Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects.: J Clin Invest. 1997 Dec 1;100(11):2737-43. Unique Identifier : AIDSLINE MED/98052575; De Paoli P; Zanussi S; Simonelli C; Bortolin MT; D'Andrea M; Crepaldi C; Talamini R; Comar M; Giacca M; Tirelli U; Department of Microbiology, Immunology, and Virology, Centro di; Riferimento Oncologico, IRCCS, 33081 Aviano, Italy. pdepaoli@ets.it; HIV infection is characterized by the reduction of the CD4+, CD45RA+, CD26+, and CD28+ lymphocyte subsets and of the in vitro production of IL-2 , IL-4, and interferon-gamma; on the contrary, chemokine production is usually increased. These abnormalities are only partia
Reduced serum IgG reactivities with bacteria from dental plaque in HIV-infected persons with periodontitis.: J Clin Periodontol. 1997 Nov;24(11):823-9. Unique Identifier : AIDSLINE MED/98066124; Steinsvoll S; Myint M; Odden K; Berild D; Schenck K; Department of Oral Biology, University of Oslo, Norway.; Serum samples were obtained from 44 HIV-seropositive (HIV+) and 37 HIV-seronegative (HIV-) persons that were grouped according to periodontal status. Serum IgG and IgA reactivities towards Streptococcus mutans, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis. Prevotella intermedia, Prevotella nigrescens
Absence of human herpesvirus 8 and Epstein-Barr virus genome sequences in cutaneous epithelial neoplasms arising in immunosuppressed organ-transplant patients.: J Cutan Pathol. 1997 Oct;24(9):559-63. Unique Identifier : AIDSLINE MED/98067357; Kohler S; Kamel OW; Chang PP; Smoller BR; Department of Pathology, Stanford University Medical Center,; California 94305, USA.; Recent studies have implicated herpesvirus 8 and Epstein-Barr virus in the development of cutaneous malignancies in immunosuppressed patients. In order to examine the strength of this association, we examined 37 malignant, pre-malignant and benign cutaneous epithelial neoplasms removed from immunosuppressed organ reci
Intestinal protein leakage in the acquired immunodeficiency syndrome.: J Clin Gastroenterol. 1997 Sep;25(2):426-8. Unique Identifier : AIDSLINE MED/98074422; Becker K; Lindner C; Frieling T; Niederau C; Reinauer H; Haussinger D; Department of Gastroenterology and Infectious Diseases, Heinrich Heine; University Medical Center, Dusseldorf, Germany.; Body wasting, protein catabolism, and hypoalbuminemia are complicating features of the acquired immunodeficiency syndrome AIDS). Given their multifactorial causes, the contributing role of intestinal protein loss has not yet been fully elucidated. To quantify enteric protein leakage, determination of fecal alpha 1-ant
Human immunodeficiency virus infection and Crohn's disease: the role of the CD4 cell in inflammatory bowel disease.: J Clin Gastroenterol. 1997 Sep;25(2):456-9. Unique Identifier : AIDSLINE MED/98074430; Lautenbach E; Lichtenstein GR; Department of Internal Medicine, Hospital of the University of; Pennsylvania, Philadelphia, USA.; Crohn s disease is believed to have an immunologic basis. The importance of the CD4 cell in particular has been supported by several reports of patients whose symptoms of Crohn s disease resolved after a decline in CD4 count associated with human immunodeficiency virus (HIV) infection. A patient with known Crohn s dis
Recombinant bacille Calmette-Guerin expressing the measles virus nucleoprotein protects infant rhesus macaques from measles virus pneumonia.: J Infect Dis. 1997 Dec;176(6):1445-53. Unique Identifier : AIDSLINE MED/98055731; Zhu YD; Fennelly G; Miller C; Tarara R; Saxe I; Bloom B; McChesney M; California Regional Primate Research Center, Department of Pathology,; Microbiology, and Immunology, School of Veterinary Medicine,; University of California, Davis 95616-8542, USA.; Measles virus infection continues to be a major cause of infant mortality. There is a need for a measles vaccine that can be administered at birth in the presence of maternal neutralizing antibody. Infant rhesus monkeys were immunized with recombinant bacille Calmette-Guerin expressing the full-length measles virus nu
Increased prevalence of infectious diseases and other adverse outcomes in human T lymphotropic virus types I- and II-infected blood donors. Retrovirus Epidemiology Donor Study (REDS) Study Group.: J Infect Dis. 1997 Dec;176(6):1468-75. Unique Identifier : AIDSLINE MED/98055734; Murphy EL; Glynn SA; Fridey J; Sacher RA; Smith JW; Wright DJ; Newman B; Gibble JW; Ameti DI; Nass CC; Schreiber GB; Nemo GJ; Department of Laboratory Medicine, University of California, San; Francisco 94143-0884, USA.; Disease associations of human T lymphotropic virus types I and II HTLV-I and -II) infection were studied in 154 HTLV-I-infected, 387 HTLV-II-infected, and 799 uninfected blood donors. Adjusted odds ratios (ORs) and 99% confidence intervals (CIs) were derived from logistic regression models controlling for demographics
Interrelationships among quantity of human cytomegalovirus (HCMV) DNA in blood, donor-recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation.: J Infect Dis. 1997 Dec;176(6):1484-90. Unique Identifier : AIDSLINE MED/98055736; Cope AV; Sabin C; Burroughs A; Rolles K; Griffiths PD; Emery VC; Department of Virology, Royal Free Hospital and School of Medicine,; London, United Kingdom.; Longitudinal analysis of 162 liver transplant recipients identified 51 patients who were viremic. Virus load was determined in 47 of these patients using quantitative-competitive polymerase chain reaction. Peak virus load was significantly higher in 20 symptomatic patients than 27 asymptomatic patients P
Varicella-zoster virus infection in children with underlying human immunodeficiency virus infection.: J Infect Dis. 1997 Dec;176(6):1496-500. Unique Identifier : AIDSLINE MED/98055738; Gershon AA; Mervish N; LaRussa P; Steinberg S; Lo SH; Hodes D; Fikrig S; Bonagura V; Bakshi S; Department of Pediatrics, Columbia University College of Physicians &; Surgeons, and Mt. Sinai Medical Center, New York, New York 10032, USA.; This article describes a prospective longitudinal study of varicella-zoster virus (VZV) infections in human immunodeficiency virus (HIV)-infected children, designed to determine their natural history of VZV infection and possible effects of VZV on the progression of HIV infection. Varicella was usually not a serious a
DNA vaccination as anti-human immunodeficiency virus immunotherapy in infected chimpanzees.: J Infect Dis. 1997 Dec;176(6):1501-9. Unique Identifier : AIDSLINE MED/98055739; Boyer JD; Ugen KE; Chattergoon M; Wang B; Shah A; Agadjanyan M; Bagarazzi ML; Javadian A; Carrano R; Coney L; Williams WV; Weiner DB; Department of Pathology, University of Pennsylvania School of; Medicine, Philadelphia 19104, USA.; The role of the immune response in controlling human immunodeficiency virus type 1 (HIV-1) replication is controversial. Immunotherapeutic strategies that have the ability to broaden immune responses might play a role in slowing disease progression. DNA immunization was studied as immunotherapy in infected chimpanzees
Human immunodeficiency virus infection impairs hemopoiesis in long-term bone marrow cultures: nonreversal by nucleoside analogues.: J Infect Dis. 1997 Dec;176(6):1510-6. Unique Identifier : AIDSLINE MED/98055740; Gill V; Shattock RJ; Scopes J; Hayes P; Freedman AR; Griffin GE; Gordon-Smith EC; Gibson FM; Department of Cellular and Molecular Sciences, St. George's Hospital; Medical School, London, UK.; Hematologic abnormalities are often seen in patients infected with human immunodeficiency virus (HIV). The effect of HIV infection of bone marrow stroma on support of uninfected CD34 progenitor cells in long-term bone marrow culture (LTBMC) was investigated. Results show that HIV-infected bone marrow stroma was unable
The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial.: J Infect Dis. 1997 Dec;176(6):1517-23. Unique Identifier : AIDSLINE MED/98055741; Deeks SG; Collier A; Lalezari J; Pavia A; Rodrigue D; Drew WL; Toole J; Jaffe HS; Mulato AS; Lamy PD; Li W; Cherrington JM; Hellmann N; Kahn J; University of California, San Francisco, San Francisco General; Hospital, 94110, USA.; Adefovir dipivoxil is a novel nucleotide analogue with several promising in vitro anti-human immunodeficiency virus (HIV) characteristics. To evaluate the safety and efficacy of adefovir dipivoxil monotherapy, a randomized, double-blind, placebo-controlled study was initiated involving 72 subjects with moderately adva
Aspergillus fumigatus conidia induce a Th1-type cytokine response.: J Infect Dis. 1997 Dec;176(6):1579-83. Unique Identifier : AIDSLINE MED/98055748; Grazziutti ML; Rex JH; Cowart RE; Anaissie EJ; Ford A; Savary CA; Department of Internal Medicine, Center for the Study of Emerging and; Reemerging Pathogens, University of Texas Medical School, Houston,; USA.; The response of human peripheral blood mononuclear cells (MNC) to Aspergillus fumigatus in vitro was evaluated. In studies of the proliferative response of MNC from 18 healthy donors to heat-killed A. fumigatus conidia, 15 displayed a significant response, with a stimulation index (SI) between 4 and 193. In contrast,
Investigation of human urine for genomic sequences of the primate polyomaviruses simian virus 40, BK virus, and JC virus.: J Infect Dis. 1997 Dec;176(6):1618-21. Unique Identifier : AIDSLINE MED/98055755; Shah KV; Daniel RW; Strickler HD; Goedert JJ; Department of Molecular Microbiology and Immunology, Johns Hopkins; University School of Public Health, Baltimore, Maryland 21205, USA.; Recent reports of the detection of simian virus 40 (SV40) nucleotide sequences in ependymomas, choroid plexus tumors, osteosarcomas, and mesotheliomas have raised the possibility that SV40, which naturally infects Asian macaques, is circulating among humans. This possibility was examined by performing polymerase chain
Plasma levels of monocyte chemoattractant protein-1 but not those of macrophage inhibitory protein-1alpha and RANTES correlate with virus load in human immunodeficiency virus infection.: J Infect Dis. 1997 Dec;176(6):1621-4. Unique Identifier : AIDSLINE MED/98055756; Weiss L; Si-Mohamed A; Giral P; Castiel P; Ledur A; Blondin C; Kazatchkine MD; Haeffner-Cavaillon N; INSERM U430 and Universite Pierre et Marie Curie, Hopital Broussais,; Paris, France.; Plasma levels of proinflammatory cytokines, cytokine inhibitors, and the beta chemokines RANTES, macrophage inhibitory protein MIP)-1alpha, and monocyte chemoattractant protein (MCP)-1 were studied in relationship with virus load in 40 patients exhibiting plasma levels of HIV RNA ranging between undetectable and level
Presence of human immunodeficiency virus (HIV) type 1 subtype A infection in a New York community with high HIV prevalence: a sentinel site for monitoring HIV genetic diversity in North America. Centers for Disease Control and Prevention-Bronx Lebanon HIV Serosurvey Team.: J Infect Dis. 1997 Dec;176(6):1629-33. Unique Identifier : AIDSLINE MED/98055758; Irwin KL; Pau CP; Lupo D; Pienazek D; Luo CC; Olivo N; Rayfield M; Hu DJ; Weber JT; Respess RA; Janssen R; Minor P; Ernst J; Centers for Disease Control and Prevention, and Orkland Corporation; Atlanta, GA 30333, USA.; To determine whether US residents are infected with subtypes of human immunodeficiency virus (HIV) type 1 other than subtype B Western), the predominant North American subtype with a unique GPGR genetic sequence in the V3 loop, viruses from 22 HIV-infected adults were serotyped and subtyped. Twenty patients had subtyp
Cytokine profiles in cerebrospinal fluid of human immunodeficiency virus-infected patients with cryptococcal meningitis: no leukocytosis despite high interleukin-8 levels. University of Zimbabwe Meningitis Group.: J Infect Dis. 1997 Dec;176(6):1633-6. Unique Identifier : AIDSLINE MED/98055759; Chaka W; Heyderman R; Gangaidzo I; Robertson V; Mason P; Verhoef J; Verheul A; Hoepelman AI; Eijkman-Winkler Institute for Microbiology, Infectious Diseases and; Inflammation, and Department of Internal Medicine, University Hospital; Utrecht, The Netherlands.; Cytokine levels were studied in the cerebrospinal fluid (CSF) of 16 adults with cryptococcal meningitis (CM). Low levels of tumor necrosis factor (TNF)-alpha and interferon-gamma, high levels of interleukin (IL)-1beta, IL-6, and IL-8, and the presence of IL-10 were documented. There were no significant differences in
Gammadelta T cells are not essential for control of cutaneous Leishmania major infection in genetically resistant C57BL/6 mice.: J Infect Dis. 1997 Dec;176(6):1649-52. Unique Identifier : AIDSLINE MED/98055763; Satoskar A; Okano M; David JR; Department of Tropical Public Health, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; As gammadelta T cells are believed to be involved in host defense against Leishmania major, the role of gammadelta T cells in immunity against this parasite was investigated. The growth of L. major was measured in alphabeta (T cell receptor [TCR] alpha -/-) and gammadelta (TCR delta -/-) TCR-deficient C57BL/6 mice and
[Campylobacter jejuni enteritis in three patients with HIV infection]: Kansenshogaku Zasshi. 1997 Oct;71(10):1071-4. Unique Identifier : AIDSLINE MED/98056490; Konishi M; Mori K; Teramoto S; Sakamoto M; Tsujimoto M; Maeda K; Hamada K; Mikasa K; Sawaki M; Koizumi A; Sano R; Masutani T; Narita N; Second Department of Internal Medicine, Nara Medical University.; Gatrointestinal symptoms, which include diarrhea, are as common as respiratory symptoms in patients with HIV infection. Gastrointestinal symptoms may result from infections, neoplasma, HIV enteropathy or drug toxicity. Three HIV-infected patients admitted to our hospital complaining of diarrhea and fever. We confirmed
[A case of cat scratch disease identified by an elevated Bartonella henselae antibody level using enzyme immunoassay]: Kansenshogaku Zasshi. 1997 Oct;71(10):1075-9. Unique Identifier : AIDSLINE MED/98056491; Kusaba N; Nakamura H; Yoshimoto K; Ogata H; Sata M; Tanikawa K; Kusaba A; Yoshida H; Second Department of Medicine, Kurume University School of Medicine.; A 68-year-old male was admitted to our hospital because of fever and a 2-week history of inguinal adenomegaly. Since he owned a cat, cat scratch disease was suspected. But it was necessary to distinguish cat scratch disease from lymphoma type adult T-cell leukemia because he showed a high level of antibody against HTL
Tragic life or tragic death. Mandatory testing of newborns for HIV--mothers' rights versus children's health.: J Leg Med. 1997 Sep;18(3):361-86. Unique Identifier : AIDSLINE MED/98056935; Madison M; Southern Illinois University School of Law, Carbondale 62901, USA.
Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens.: J Exp Med. 1997 Dec 15;186(12):2039-43. Unique Identifier : AIDSLINE MED/98060863; Tian J; Lehmann PV; Kaufman DL; Department of Molecular and Medical Pharmacology, University of; California, Los Angeles, California 90095-1735, USA.; The nature (Th1 versus Th2) and dynamics of the autoimmune response during the development of insulin-dependent diabetes mellitus (IDDM) and after immunotherapy are unclear. Here, we show in nonobese diabetic (NOD) mice that the autoreactive T cell response starts and spreads as a pure Th1 type autoimmunity, suggestin
CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity.: J Exp Med. 1997 Dec 15;186(12):2057-62. Unique Identifier : AIDSLINE MED/98060866; Kurts C; Carbone FR; Barnden M; Blanas E; Allison J; Heath WR; Miller JF; Immunology Division, The Walter and Eliza Hall Institute of Medical; Research, Victoria 3050, Australia.; Self-antigens expressed in extrathymic tissues such as the pancreas can be transported to draining lymph nodes and presented in a class I-restricted manner by bone marrow-derived antigen-presenting cells. Such cross-presentation of self-antigens leads to CD8+ T cell tolerance induction via deletion. In this report, we
Resistance to and recovery from lethal influenza virus infection in B lymphocyte-deficient mice.: J Exp Med. 1997 Dec 15;186(12):2063-8. Unique Identifier : AIDSLINE MED/98060867; Graham MB; Braciale TJ; Beirne B. Carter Center for Immunology Research, University of; Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.; mbgraham@uic.edu; In the adaptive immune response to most viruses, both the cellular and humoral arms of the immune system play complementary roles in eliminating virus and virus-infected cells and in promoting recovery. To evaluate the relative contribution of CD4+ and CD8+ effector T lymphocytes in virus clearance and recovery, we ha
Itk and Fyn make independent contributions to T cell activation.: J Exp Med. 1997 Dec 15;186(12):2069-73. Unique Identifier : AIDSLINE MED/98060868; Liao XC; Littman DR; Weiss A; Department of Microbiology and Immunology, Howard Hughes Medical; Institute, University of California, San Francisco, California 94143,; USA.; Itk is a member of the Btk/Tec/Itk family of nonreceptor protein tyrosine kinases (PTKs), and has been implicated in T cell antigen receptor (TCR) signal transduction. Lck and Fyn are the Src-family nonreceptor PTKs that are involved in TCR signaling. To address the question of how these members of different families
Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine.: J Med Chem. 1997 Nov 21;40(24):3969-73. Unique Identifier : AIDSLINE MED/98059327; Pelicano H; Pierra C; Eriksson S; Gosselin G; Imbach JL; Maury G; UMR 5626 du CNRS, Departement de Chimie Organique Fine, Universite; Montpellier-2 des Sciences et Techniques du Languedoc, France.; The beta-L-enantiomers of 2 ,3 -dideoxyadenosine and 2 ,3 -didehydro-2 ,3 -dideoxyadenosine have been stereospecifically synthesized. In an attempt to explain the previously reported antiviral activities of these compounds, their enzymatic properties were studied with respect to adenosine kinase, deoxycytidine kinase,
Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.: J Med Chem. 1997 Nov 21;40(24):3979-85. Unique Identifier : AIDSLINE MED/98059329; Kaldor SW; Kalish VJ; Davies JF 2nd; Shetty BV; Fritz JE; Appelt K; Burgess JA; Campanale KM; Chirgadze NY; Clawson DK; Dressman BA; Hatch SD; Khalil DA; Kosa MB; Lubbehusen PP; Muesing MA; Patick AK; Reich SH; Su KS; Tatlock JH; Agouron Pharmaceuticals, Inc., San Diego, California 92121, USA.; Using a combination of iterative structure-based design and an analysis of oral pharmacokinetics and antiviral activity, AG1343 Viracept , nelfinavir mesylate), a nonpeptidic inhibitor of HIV-1 protease, was identified. AG1343 is a potent enzyme inhibi
Prognostic indicators for AIDS and infectious disease death in HIV-infected injection drug users: plasma viral load and CD4+ cell count.: JAMA. 1998 Jan 7;279(1):35-40. Unique Identifier : AIDSLINE MED/98084657; Vlahov D; Graham N; Hoover D; Flynn C; Bartlett JG; Margolick JB; Lyles CM; Nelson KE; Smith D; Holmberg S; Farzadegan H; Department of Epidemiology, The Johns Hopkins School of Hygiene and; Public Health, Baltimore, MD 21205, USA. DVLAHOV@jhsph.edu; CONTEXT: Plasma human immunodeficiency virus type 1 (HIV-1) viral load and CD4+ cell count are used to predict prognosis of persons infected with HIV. However, whether combining these markers improves prognostic accuracy and whether they predict prognosis for injection drug users (IDUs) and nonwhite persons infected w
Rural communities struggle with AIDS [news]: JAMA. 1998 Jan 7;279(1):5-6. Unique Identifier : AIDSLINE MED/98084641; Voelker R
Protein tyrosine kinase activation provides an early and obligatory signal in anti-FRP-1/CD98/4F2 monoclonal antibody induced cell fusion mediated by HIV gp160.: Med Microbiol Immunol (Berl). 1997 Oct;186(2-3):115-23. Unique Identifier : AIDSLINE MED/98067616; Tabata N; Ido M; Suga S; Ohgimoto S; Tsurudome M; Kawano M; Nishio M; Watanabe N; Okamoto K; Komada H; Sakurai M; Ito Y; Department of Microbiology, Mie University School of Medicine, Japan.; The mechanism by which anti-fusion regulatory protein-1 (FRP-1) monoclonal antibody (mAb) induced cell fusion was investigated using U2ME-7 cells that are CD4+U937 cells transfected with the HIV gp160 gene. Protein kinase inhibitors (H-7, H-89, herbimycin A and genistein) suppressed cell fusion of Cd+U2ME-7 cells indu
A rapid and sensitive method for non-isotopic quantitation of HIV-1 RNA using thermophilic SDA and flow cytometry.: Mol Cell Probes. 1997 Oct;11(5):337-47. Unique Identifier : AIDSLINE MED/98042863; Mehrpouyan M; Bishop JE; Ostrerova N; Van Cleve M; Lohman KL; Becton Dickinson Immunocytometry Systems, San Jose, CA 95131-1807,; USA.; Thermophilic strand displacement amplification (tSDA) is an isothermal DNA amplification technique that proceeds at 55-60 degrees C using both a thermostable restriction enzyme and a DNA polymerase. A modification of this system has been developed that allows the simultaneous amplification and detection of a DNA targe
Kaposi's sarcoma. Coupling herpesvirus to angiogenesis [news; comment]: Nature. 1998 Jan 1;391(6662):24-5. Unique Identifier : AIDSLINE MED/98082966; Boshoff C
Milking the wound [letter]: Nurse Educ. 1997 Nov-Dec;22(6):7. Unique Identifier : AIDSLINE MED/98077980; Solenberger P
30 years later--a new approach to Sol Spiegelman's and Leslie Orgel's in vitro evolutionary studies. Dedicated to Leslie Orgel on the occasion of his 70th birthday.: Orig Life Evol Biosph. 1997 Dec;27(5-6):437-57. Unique Identifier : AIDSLINE MED/98056335; Oehlenschlager F; Eigen M; Max-Planck-Institut fur Biophysikalische Chemie, Gottingen.; The conditions necessary for evolution are amplification, mutagenesis and selection. Here we describe the evolutionary response of an in vitro replicating system to the selection pressure for fast growth and show what happens to the amplified molecules within this replication system. Our emphasis is on methodology, on
[Principles of counseling and care of HIV-1 seropositive pregnant women in the light of a Hungarian case]: Orv Hetil. 1997 Nov 23;138(47):2987-90. Unique Identifier : AIDSLINE MED/98067929; Czeizel E; Banhegyi D; Orszagos Kozegeszsegugyi Intezet, Humangenetikai es Teratologiai; Osztaly-WHO Orokletes Artalmak Tarsadalmi Megelozese Egyuttmukodesi; Kozpont, Budapest.; HIV-1 infected pregnant woman with minor HIV-related symptoms insisted on her pregnancy. Having been on zidovudine prophylaxis ACTG 076) she delivered a healthy girl and DNA PCR test indicated the lack of her infection. Principles of counselling, care and obstetric management of HIV infected pregnant women are also su
Detection of HIV p24 from antigen presenting monocytes for early diagnosis of HIV-1 infection.: Panminerva Med. 1997 Sep;39(3):159-64. Unique Identifier : AIDSLINE MED/98024799; Pugliese A; Savarino A; Cantamessa C; Bernengo MG; Department of Medical and Surgical Sciences, University of Turin,; Italy.; The monocytic/macrophagic lineage has an antigen presenting cell function also towards HIV. On the basis of this fact, a new method, indirect immunofluorescence (IIF) for measurement of p24 from monocytes was used. The results were compared to an amplified enzymatic test for serum dissociated p24 detection in 14 HIV n
Immune response to the filaria Litomosoides sigmodontis in susceptible and resistant mice.: Parasite Immunol. 1997 Jun;19(6):273-9. Unique Identifier : AIDSLINE MED/98031140; Marechal P; Le Goff L; Hoffman W; Rapp J; Oswald IP; Ombrouck C; Taylor DW; Bain O; Petit G; Laboratoire de Biologie Parasitaire, Protistologie, Helminthologie,; URA 114 associe au CNRS, Paris, France.; Comparisons were made between the immune responses evoked during the course of chronic and patient infections of Litomosoides sigmodontis in susceptible BALB/c mice and non-patent infections in resistant B10.D2 mice. Early antigen specific responses of spleen cells were weak in both mouse strains. However, by day 58 p
TAR RNA decoys inhibit tat-activated HIV-1 transcription after preinitiation complex formation.: Nucleic Acids Res. 1997 Nov 15;25(22):4481-6. Unique Identifier : AIDSLINE MED/98026834; Bohjanen PR; Liu Y; Garcia-Blanco MA; Department of Pharmacology and Cancer Biology, Levine Science Research; Center, Duke University Medical Center, Durham, NC 27710, USA.; The ability of the HIV-1 Tat protein to trans -activate HIV-1 transcription in vitro is specifically inhibited by a circular TAR RNA decoy. This inhibition is not overcome by adding an excess of Tat to the reaction but is partially overcome by adding Tat in combination with nuclear extract, suggesting that TAR RNA mig
Binding of Hoechst 33258 to the TAR RNA of HIV-1. Recognition of a pyrimidine bulge-dependent structure.: Nucleic Acids Res. 1997 Nov 15;25(22):4487-92. Unique Identifier : AIDSLINE MED/98026835; Dassonneville L; Hamy F; Colson P; Houssier C; Bailly C; Laboratoire de Pharmacologie Moleculaire Antitumorale du Centre Oscar; Lambret et INSERM Unite 124, Place de Verdun, 59045 Lille, France.; The transactivation response region (TAR) RNA is an essential component in transcriptional regulation of the human immunodeficiency virus type-1 (HIV-1) genome. We have examined the interaction between TAR RNA and the bisbenzimidazole derivative Hoechst 33258. Previous studies have shown that this drug, which is well
Higher fidelity of RNA-dependent DNA mispair extension by M184V drug-resistant than wild-type reverse transcriptase of human immunodeficiency virus type 1.: Nucleic Acids Res. 1997 Nov 15;25(22):4532-6. Unique Identifier : AIDSLINE MED/98026841; Hsu M; Inouye P; Rezende L; Richard N; Li Z; Prasad VR; Wainberg MA; Department of Microbiology and Immunology, McGill University,; Montreal, Canada.; Reverse transcriptase (RT) of human immunodeficiency virus type 1 HIV-1) has low fidelity compared with RTs of other retroviruses and cellular DNA polymerases. We and others have previously found that the fidelity of DNA-dependent DNA polymerization (DDDP) of M184V-mutated HIV-1 RT is significantly higher than that of
Deoxyribonucleotide-containing RNAs: a novel class of templates for HIV-1 reverse transcriptase.: Nucleic Acids Res. 1997 Nov 15;25(22):4614-8. Unique Identifier : AIDSLINE MED/98026852; Gudima SO; Kazantseva EG; Kostyuk DA; Shchaveleva IL; Grishchenko OI; Memelova LV; Kochetkov SN; Engelhardt Institute of Molecular Biology, Russian Academy of; Sciences, 117984 Moscow, Russia.; Deoxyribonucleotide-containing RNA-like polynucleotides (dcRNAs) were synthesized by mutant T7 RNA polymerase and their structures confirmed by sequencing. dcRNAs annealed with a 20mer oligodeoxyribonucleotide primer were tested as templates/primers in the reverse transcription reaction catalyzed by HIV-1 reverse tran
Growing pains.: Nurs Times. 1997 Nov 26-Dec 2;93(48):12-3. Unique Identifier : AIDSLINE MED/98085517; Gulland A
Unite and fight.: Nurs Times. 1997 Nov 26-Dec 2;93(48):13. Unique Identifier : AIDSLINE MED/98085518; Carlisle D
Long QTc and torsades de pointes in human immunodeficiency virus disease.: Pacing Clin Electrophysiol. 1997 Nov;20(11):2810-6. Unique Identifier : AIDSLINE MED/98054522; Kocheril AG; Bokhari SA; Batsford WP; Sinusas AJ; Section of Cardiovascular Medicine, Yale University School of; Medicine, New Haven Connecticut 06510, USA.; Three patients with human immunodeficiency virus (HIV) infection presented with QT, prolongation (> 440 ms) and torsades de pointes. We sought to evaluate the etiology of the long QT syndrome in these patients without previously identified causes for QT, prolongation, and determine the prevalence among patients with H
Disseminated bacillus Calmette-Guerin infection in an HIV-infected child: a case with cutaneous lesions.: Pediatr Dermatol. 1997 Sep-Oct;14(5):365-8. Unique Identifier : AIDSLINE MED/97477874; Raton JA; Pocheville I; Vicente JM; Gonzalez R; Bilbao I; Gutierrez C; Diaz-Perez JL; Department of Dermatology, Cruces Hospital, Bilbao, Spain.; A boy born to a mother with unknown HIV infection was immunized with BCG in his first month of life. Seven months later axillary adenopathy developed. At the age of 10 months, 2 months after HIV infection had been diagnosed, papular skin lesions appeared all over his body. Mycobacterium bovis, BCG strain, was cultured
Inhibition of HIV type 1 infectivity by constrained alpha-helical peptides: implications for the viral fusion mechanism.: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13426-30. Unique Identifier : AIDSLINE MED/98054249; Judice JK; Tom JY; Huang W; Wrin T; Vennari J; Petropoulos CJ; McDowell RS; Department of Bioorganic Chemistry, Genentech, Inc., 460 Point San; Bruno Boulevard, South San Francisco, CA 94080, USA.; Linear peptides derived from the membrane proximal region of the gp41 ectodomain are effective inhibitors of HIV type 1 HIV-1)-mediated fusion events. These inhibitory peptides lack structure in solution, rendering mechanistic interpretation of their activity difficult. Using structurally constrained analogs of these
The nucleocapsid protein specifically anneals tRNALys-3 onto a noncomplementary primer binding site within the HIV-1 RNA genome in vitro.: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13530-5. Unique Identifier : AIDSLINE MED/98054268; Chan B; Musier-Forsyth K; University of Minnesota, Department of Chemistry, 207 Pleasant Street; SE, Minneapolis, MN 55455, USA.; HIV type 1 (HIV-1) specifically uses host cell tRNALys-3 as a primer for reverse transcription. The 3 18 nucleotides of this tRNA are complementary to a region on the HIV RNA genome known as the primer binding site (PBS). HIV-1 has a strong preference for maintaining a lysine-specific PBS in vivo, and viral genomes w
Decreased ability of HIV-1 tat protein-treated accessory cells to organize cellular clusters is associated with partial activation of T cells.: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13832-7. Unique Identifier : AIDSLINE MED/98054321; Wu MX; Schlossman SF; Division of Tumor Immunology, Room 751, Dana-Farber Cancer Institute,; and Department of Medicine, Harvard Medical School, Boston, MA 02115,; USA. mei@mbcrr.harvard.edu; It has been shown in several animal models that HIV infection of accessory cells (ACs) plays an important role in development of AIDS. Here, we report that ACs treated with HIV-1 Tat protein Tat-ACs) have a decreased ability to organize cellular aggregates as compared with untreated ACs, resulting in incomplete activa
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins.: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13897-902. Unique Identifier : AIDSLINE MED/98054332; Takemoto S; Mulloy JC; Cereseto A; Migone TS; Patel BK; Matsuoka M; Yamaguchi K; Takatsuki K; Kamihira S; White JD; Leonard WJ; Waldmann T; Franchini G; Basic Research Laboratory, Division of Basic Sciences, National Cancer; Institute, Bethesda, MD 20892, USA.; Human T cell leukemia/lymphotropic virus type I (HTLV-I) induces adult T cell leukemia/lymphoma (ATLL). The mechanism of HTLV-I oncogenesis in T cells remains partly elusive. In vitro, HTLV-I induces ligand-independent transformation of human CD4+ T cells, an event that correlates with acquisition of constitutive phos
A new ozone-based method for virus inactivation: preliminary study.: Phys Med Biol. 1997 Nov;42(11):2027-39. Unique Identifier : AIDSLINE MED/98056241; Kekez MM; Sattar SA; National Research Council of Canada, Ottawa, Ontario, Canada.; The nebulization technique reported here could be used to inactivate viruses with ozone in large volumes of body fluids, such as plasma, partial blood and perhaps whole blood in a short time. Coliphage MS2 was used as a model because it is safe, easy to handle and more resistant to chemical disinfections than viruses
Fear of AIDS and Homophobia Scales: additional estimates of reliability and validity.: Psychol Rep. 1997 Dec;81(3 Pt 1):783-6. Unique Identifier : AIDSLINE MED/98062578; Miller DB; Briggs H; Corcoran K; Mandell School of Applied Social Sciences, Case Western Reserve; University, USA.; Psychometric properties of the Fear of AIDS Scale and the Homophobia Scale from 85 heterosexual undergraduates (and 44 gay, lesbian, and bisexual undergraduates) were estimated. Responses on the Homophobia Scale were internally consistent (alpha = .88), had 4% standard error of measurement, and scores differed by subj
Loneliness and sexual risk behavior in gay men.: Psychol Rep. 1997 Dec;81(3 Pt 1):815-25. Unique Identifier : AIDSLINE MED/98062580; Martin JI; Knox J; University of Texas at Arlington, USA.; This study examined loneliness in a sample of gay men and its association with unprotected anal intercourse, social support, instability of self-esteem, intimacy, and coping. A sample of 470 urban gay men completed a self-administered questionnaire. Participants scored high on Loneliness in comparison to other samples
Epidemiological and clinical features of pulmonary blastomycosis.: Semin Respir Infect. 1997 Sep;12(3):206-18. Unique Identifier : AIDSLINE MED/97458472; Davies SF; Sarosi GA; University of Minnesota Medical School, Hennepin County Medical; Center, Minneapolis 55415, USA.; The epidemiological and clinical aspects of Blastomycosis are reviewed. The central United States is the most heavily endemic area in the world, although the extent of the endemic zone has been mapped only by individual case finding, rather than by large skin test surveys (as was done
Blastomycosis in the immunocompromised patient.: Semin Respir Infect. 1997 Sep;12(3):243-51. Unique Identifier : AIDSLINE MED/97458476; Pappas PG; Division of Infectious Diseases, University of Alabama at Birmingham,; USA.; Blastomycosis has become increasingly recognized as a serious infection in immunocompromised hosts in recent years. Underlying disorders among these patients include conditions that are typically characterized by abnormalities of T-lymphocyte function such as acquired immunodeficiency syndrome, long-term glucocorticos
[HIV and vitamin C (news)]: Schweiz Rundsch Med Prax. 1997 Oct 15;86(42):1667. Unique Identifier : AIDSLINE MED/98027553
[Toxic drug-induced proximal myopathy in CDC C3 HIV-infection]: Schweiz Rundsch Med Prax. 1997 Oct 22;86(43):1708-10. Unique Identifier : AIDSLINE MED/98045274; Weisser M; Medizinische Universitatspoliklinik, Kantonsspital Basel.
Renaissance for Italian AIDS program [news]: Science. 1997 Dec 19;278(5346):2061. Unique Identifier : AIDSLINE MED/98092053
Animal models of HIV-1 disease.: Science. 1997 Dec 19;278(5346):2141-2. Unique Identifier : AIDSLINE MED/98092057; McCune JM; Gladstone Institute of Virology and Immunology, University of; California, San Francisco 94110-9100, USA.; mike_mccune.giv@quickmail.ucsf.edu
[Nutritional support and HIV]: Soins. 1997 Oct;(619):33-4. Unique Identifier : AIDSLINE MED/98078112; Besse J; HAD AP-HP, Charenton.
Induction of tolerance with nondepleting anti-CD4 monoclonal antibodies is associated with down-regulation of TH2 cytokines.: Transplantation. 1997 Dec 15;64(11):1559-67. Unique Identifier : AIDSLINE MED/98076038; Plain KM; Fava L; Spinelli A; He XY; Chen J; Boyd R; Davidson CL; Hall BM; University of New South Wales, Department of Medicine, Liverpool; Hospital, Australia.; BACKGROUND: Induction of tolerance with anti-CD4 has mainly focused on monoclonal antibodies (mAbs) that deplete CD4+ T cells. In this study, the mechanisms by which nondepleting anti-CD4 mAbs induce tolerance in the Dark Agouti to PVG rat heart graft model were examined. METHODS: Five anti-CD4 mAbs were tested. Immun
Efficacy and safety of lamivudine on replication of recurrent hepatitis B after cadaveric renal transplantation.: Transplantation. 1997 Dec 15;64(11):1624-7. Unique Identifier : AIDSLINE MED/98076054; Rostaing L; Henry S; Cisterne JM; Duffaut M; Icart J; Durand D; Multi-Organ Transplant Unit, Department of Internal Medicine, Toulouse; University Hospital, France.; BACKGROUND: The aim of this pilot study was to evaluate the efficacy and the safety of lamivudine therapy in hepatitis B virus (HBV)-positive/DNA-positive renal transplant recipients. METHODS: Six HBV DNA-positive cadaveric renal transplant recipients ranging in age from 49+/-6 years were administered lamivudine, at 1
Apoptosis of CD4+ and CD19+ cells during human immunodeficiency virus type 1 infection--correlation with clinical progression, viral load, and loss of humoral immunity.: Virology. 1997 Nov 24;238(2):180-8. Unique Identifier : AIDSLINE MED/98063238; Samuelsson A; Brostrom C; van Dijk N; Sonnerborg A; Chiodi F; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.; Enhanced rates of programmed cell death (apoptosis) have been detected in T cells and B cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals. To evaluate the possible relevance of this event to HIV pathogenesis and disease progression, apoptosis in CD4+ T lymphocytes and CD19+ B lymphocytes, vir
Phylogenetic analysis of simian T-lymphotropic virus Type I STLV-I) in common chimpanzees (Pan troglodytes): evidence for interspecies transmission of the virus between chimpanzees and humans in Central Africa.: Virology. 1997 Nov 24;238(2):212-20. Unique Identifier : AIDSLINE MED/98063241; Voevodin AF; Johnson BK; Samilchuk EI; Stone GA; Druilhet R; Greer WJ; Gibbs CJ Jr; Department of Microbiology, Faculty of Medicine, Kuwait University,; Safat, Kuwait.; Serum and peripheral blood leukocytes from the chimpanzees (Pan troglodytes) of the colony of the Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, NIH, were tested for the presence of STLV-I-specific antibodies and proviral DNA. Antibodies were determined by gelati
Interactions between Tat of HIV-2 and transcription factor Sp1.: Virology. 1997 Nov 24;238(2):221-30. Unique Identifier : AIDSLINE MED/98063242; Pagtakhan AS; Tong-Starksen SE; Department of Medicine, Veterans Administration Medical Center, San; Francisco, California, USA.; Tat of HIV-2 (Tat-2) requires host cellular factors for optimal function. We show that transactivation by Tat-2 of the HIV promoter requires cis-acting binding sites for Sp1 or Sp1 brought to the promoter via a heterologous system. We demonstrate that an activation domain in Tat-2 consists of one of two potential alph
Direct effect of type 1 human immunodeficiency virus (HIV-1) on intestinal epithelial cell differentiation: relationship to HIV-1 enteropathy.: Virology. 1997 Nov 24;238(2):231-42. Unique Identifier : AIDSLINE MED/98063243; Delezay O; Yahi N; Tamalet C; Baghdiguian S; Boudier JA; Fantini J; Laboratoire de Biochimie et Biologie de la Nutrition, UPRESA-CNRS; 6033, Faculte des Sciences de St Jerome, Marseille.; Human immunodeficiency virus (HIV)-infected patients display severe impairments of gastrointestinal functions, including diarrhea and malabsorption, even in the absence of opportunistic infections. Since HIV-1 proteins and nucleic acids have been detected in several cell types of the intestinal mucosa, it has been pos
Passage of HIV-1 molecular clones into different cell lines confers differential sensitivity to neutralization.: Virology. 1997 Nov 24;238(2):254-64. Unique Identifier : AIDSLINE MED/98063245; Zhang YJ; Fredriksson R; McKeating JA; Fenyo EM; Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm,; Sweden.; In this study, progeny viruses of four HIV-1 molecular clones were tested for sensitivity to neutralization following prolonged passage in peripheral blood mononuclear cells (PBMC) and MT-2, H9, and CEM T-lymphoid cell lines. Two of the viruses were able to establish persistent infection with no cytopathic effect in H
Insights into the interaction between tRNA and primer binding site from characterization of a unique HIV-1 virus which stably maintains dual PBS complementary to tRNA(Gly) and tRNA(His).: Virology. 1997 Nov 24;238(2):273-82. Unique Identifier : AIDSLINE MED/98063247; Li Y; Zhang Z; Kang SM; Buescher JL; Morrow CD; Department of Microbiology, University of Alabama at Birmingham 35294,; USA.; Previously our laboratory constructed an HIV-1 which stably maintained a primer binding site (PBS) complementary to tRNA(His) by mutating the region of the provirus within U5 postulated to interact with the anticodon of tRNA(His) (J. Wakefield, S-M Kang, and C. D. Morrow, 1996, J. Virol, 70, 966-975). From the analysi
Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family.: Virology. 1997 Nov 24;238(2):305-15. Unique Identifier : AIDSLINE MED/98063250; Ohno H; Aguilar RC; Fournier MC; Hennecke S; Cosson P; Bonifacino JS; Cell Biology and Metabolism Branch, National Institute of Child Health; and Human Development, National Institutes of Health, Bethesda,; Maryland 20892, USA.; The envelope glycoprotein (Env) complex of HIV-1 undergoes rapid internalization from the plasma membrane of human cells by virtue of a tyrosine-based endocytic signal (RQGYSPL, residues 704-710) in the cytosolic tail of the protein (J. F. Rowell et al., J. Immunol. 155, 473-488, 1995). Here we demonstrate that this t
Serial in vivo passage of HIV-1 infection in Macaca nemestrina.: Virology. 1997 Nov 24;238(2):336-43. Unique Identifier : AIDSLINE MED/98063253; Agy MB; Schmidt A; Florey MJ; Kennedy BJ; Schaefer G; Katze MG; Corey L; Morton WR; Bosch ML; Regional Primate Research Center, University of Washington, Seattle; 98195, USA. magy@u.washington.edu; In an earlier study we found that pigtailed macaques (Macaca nemestrina) that were experimentally infected with human immunodeficiency virus type 1 (HIV-1) initially became viremic and seroconverted, but HIV-1 replication diminished markedly over time. In an attempt to develop a longer term pathogenic model, blood fro
Hantavirus pulmonary syndrome: CD8+ and CD4+ cytotoxic T lymphocytes to epitopes on Sin Nombre virus nucleocapsid protein isolated during acute illness.: Virology. 1997 Nov 24;238(2):380-90. Unique Identifier : AIDSLINE MED/98063258; Ennis FA; Cruz J; Spiropoulou CF; Waite D; Peters CJ; Nichol ST; Kariwa H; Koster FT; Center for Infectious Disease and Vaccine Research, University of; Massachusetts, Worcester 01655, USA.; In 1993 a number of cases of unexplained adult respiratory syndrome occurred in the southwestern United States . The illness was characterized by a prodrome of fever, myalgia, and other symptoms followed by the rapid onset of a capillary leak syndrome with hemoconcentration, thrombocyto
Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.: Virology. 1997 Nov 24;238(2):432-43. Unique Identifier : AIDSLINE MED/98063262; Ruediger R; Brewis N; Ohst K; Walter G; Department of Pathology, University of California at San Diego, La; Jolla 92093-0612, USA.; We demonstrated previously that PP2A exists in many cell types as two abundant forms: (1) holoenzyme composed of two regulatory subunits, A and B, and a catalytic subunit C; and (2) core enzyme consisting of the A and C subunits. These two forms have different substrate specificities. Since published data suggested th
Our safety is important, too.: Am J Nurs. 1997 Dec;97(12):80. Unique Identifier : AIDSLINE MED/98075259; Arnold L; Pennsylvania Nurses Association, USA.
A strategy for rapid, high-confidence protein identification.: Anal Chem. 1997 Oct 1;69(19):3995-4001. Unique Identifier : AIDSLINE MED/97463734; Qin J; Fenyo D; Zhao Y; Hall WW; Chao DM; Wilson CJ; Young RA; Chait BT; Rockefeller University, New York, New York 10021, USA.; A procedure is described for rapid, high-confidence identification of proteins using matrix-assisted laser desorption/ionization tandem ion trap mass spectrometry in conjunction with a genome database searching strategy. The procedure involves excision of copper-stained bands or spots from electrophoretic gels, in-gel
Universal skew of T cell receptor (TCR) V beta usage for Crohn's disease (CrD).: Biochem Biophys Res Commun. 1997 Nov 26;240(3):545-51. Unique Identifier : AIDSLINE MED/98063273; Ogawa H; Ito H; Takeda A; Kanazawa S; Yamamoto M; Nakamura H; Kimura Y; Yoshizaki K; Kishimoto T; Department of Medicine III, Osaka University Medical School, Japan.; It would be of clear interest and importance to identify T cell populations which correlate with the initiation of some T cell-mediated diseases; however, it is difficult to observe the initial response of T cells in these diseases because of modification due to immunosuppressive treatment. We investigated T cell rece
Downregulation of MAP kinase activity signalled by HIV-1-gp120 coat protein in granular neurons and glial cells from rat cerebellum.: Biochem Biophys Res Commun. 1997 Nov 26;240(3):683-6. Unique Identifier : AIDSLINE MED/98063298; Leoni C; Menegon A; Benfenati F; Valtorta F; DIBIT San Raffaele Scientific Institute, B. Ceccarelli, Milano, Italy.; We have studied the effect of gp120 coat protein from HIV-1 on tyrosine phosphorylation processes in primary cultures of granular neurons or glial cells from the cerebellum of neonatal rats. The extracellular application of recombinant gp120 (200 pM) was able to reduce the phosphotyrosine content and the immunoreactiv
The interaction of HIV-1 Tat(32-72) with its target RNA: a fluorescence and nuclear magnetic resonance study.: Biochem Biophys Res Commun. 1997 Dec 8;241(1):31-6. Unique Identifier : AIDSLINE MED/98070900; Metzger AU; Bayer P; Willbold D; Hoffmann S; Frank RW; Goody RS; Rosch P; Lehrstuhl fur Biopolymere, Universitat Bayreuth, Bayreuth, D-95440,; Germany.; We performed intrinsic peptide fluorescence experiments to characterize the interaction between variants of the HIV-1 Tat(32-72) peptide BP1 and TAR RNA. Kd values for wild-type BP1 and cysteine-modified BP1 were found to be in the range of 60 to 70 nM for both peptides, indicating that free sulfhydryl groups of the c
Evaluation of anti-hepatitis B virus (HBV) drugs using the HBV transgenic mouse: application of the semiquantitative polymerase chain reaction (PCR) for serum HBV DNA to monitor the drug efficacy.: Biochem Biophys Res Commun. 1997 Dec 8;241(1):43-8. Unique Identifier : AIDSLINE MED/98070902; Kajino K; Kamiya N; Yuasa S; Takahara T; Sakurai J; Yamamura Ki; Hino O; Department of Experimental Pathology, Cancer Institute, 1-37-1; Kami-Ikebukuro, Toshimaku, Tokyo, 170, Japan.; For evaluation of anti-hepatitis B virus (HBV) drugs, we have employed the HBV transgenic mouse in which virion-like particles can be assayed in the serum. Bispivaloyloxymethyl-9-(2-phosphonylmethoxyethyl)-adenine [bis POM) PMEA] 100 mg/kg/day, 2 ,3 -dideoxy-3 -thiacytidine [(+-)-BCH189] 200 mg/kg/day and a placebo we
Th1/Th2 cytokine balance in arthritis.: Arthritis Rheum. 1997 Dec;40(12):2105-15. Unique Identifier : AIDSLINE MED/98077328; Miossec P; van den Berg W; Hopital Edouard Herriot, Lyon, France.
Ribozyme-based gene cleavage approach to chronic arthritis associated with human T cell leukemia virus type I: induction of apoptosis in synoviocytes by ablation of HTLV-I tax protein.: Arthritis Rheum. 1997 Dec;40(12):2118-27. Unique Identifier : AIDSLINE MED/98077330; Kitajima I; Hanyu N; Kawahara K; Soejima Y; Kubo T; Yamada R; Kaneda Y; Maruyama I; Kagoshima University, Kagoshima City, Japan.; OBJECTIVE. To develop gene therapy for patients with human T cell leukemia virus type I (HTLV-I)-associated arthropathy (HAAP), we investigated the effects of ribozyme-mediated cleavage of HTLV-I tax/rex messenger RNA (mRNA) on synovial overgrowth. METHODS. We introduced 2 hammerhead ribozymes targeted against HTLV-I
Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production.: Arthritis Rheum. 1997 Dec;40(12):2162-71. Unique Identifier : AIDSLINE MED/98077335; Voll RE; Roth EA; Girkontaite I; Fehr H; Herrmann M; Lorenz HM; Kalden JR; Friedrich-Alexander-University, Erlangen, Germany.; OBJECTIVE. To investigate whether histone-specific T helper (Th) cells that are able to induce anti-double-stranded DNA anti-dsDNA) antibodies can be isolated from patients with systemic lupus erythematosus (SLE) and to characterize the cytokine secretion pattern of such Th clones. METHODS. Peripheral blood mononuclea
Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus: correlation with serum antinucleosome antibody titers and absence of clear association with disease activity.: Arthritis Rheum. 1997 Dec;40(12):2217-25. Unique Identifier : AIDSLINE MED/98077342; Amoura Z; Piette JC; Chabre H; Cacoub P; Papo T; Wechsler B; Bach JF; Koutouzov S; Hopital Pitie-Salpetriere, Paris, France.; OBJECTIVE. To assess nucleosome plasma levels in patients with systemic lupus erythematosus (SLE) and to study the correlations with serum antinucleosome, anti-double-stranded DNA (anti-dsDNA), and antihistone antibody activities, as well as with disease activity (by the SLE Disease Activity Index [SLEDAI]). METHODS.
Universal precautions are not needed for health care workers handling breast milk [editorial]: J Hum Lact. 1997 Dec;13(4):267-8. Unique Identifier : AIDSLINE MED/98091191; Nommsen-Rivers L
ILCA's position on the issue of HIV and infant feeding.: J Hum Lact. 1997 Dec;13(4):269. Unique Identifier : AIDSLINE MED/98091192
Paediatric HIV update.: J Paediatr Child Health. 1997 Oct;33(5):373-7. Unique Identifier : AIDSLINE MED/98065439; Ziegler JB; Palasanthiran P; Department of Immunology/Allergy, Sydney Children's Hospital,; Randwick, New South Wales, Australia.; Less than half of the paediatric HIV infections recorded in Australia have resulted from perinatal transmission, but in recent years this has been the predominant mode of infection. There are 136 infants who are known to have been exposed perinatally to HIV in Australia: 49 of t
Factors associated with aggressive and delinquent behaviors among patients attending an adolescent medicine clinic.: J Adolesc Health. 1997 Nov;21(5):303-8. Unique Identifier : AIDSLINE MED/98023130; Durant RH; Knight J; Goodman E; Brenner Center on Maternal, Child, and Adolescent Health, Department; of Pediatrics, Brenner Children's Hospital, Bowman Gray School of; Medicine, Wake Forest University, Winston-Salem, North Carolina 27157,; USA.; PURPOSE: The purpose of this study was to examine the associations among delinquency/aggressiveness and alcohol or drug use, sexual risk behaviors, and other scales from the Problem-Oriented Screening Instrument for Teenagers (POSIT). METHOD: A total of 173 15- to 18-year-olds attending adolescent medicine clinic comp
Preventing the spread of AIDS in youth: principles of practice from 11 diverse projects.: J Adolesc Health. 1997 Nov;21(5):309-17. Unique Identifier : AIDSLINE MED/98023131; Wren PA; Janz NK; Carovano K; Zimmerman MA; Washienko KM; Department of Health Behavior and Health Education, School of Public; Health, University of Michigan, Ann Arbor 48109-2029, USA.; PURPOSE: The purpose of this study was to identify the factors that contributed to intervention effectiveness in acquired immunodeficiency syndrome (AIDS) prevention projects targeting youth. METHODS: Eleven AIDS prevention projects funded by the Robert Wood Johnson Foundation whose target populations consisted of at
Predictors of reported condom use in central Harlem youth as conceptualized by the health belief model.: J Adolesc Health. 1997 Nov;21(5):318-27. Unique Identifier : AIDSLINE MED/98023132; Laraque D; McLean DE; Brown-Peterside P; Ashton D; Diamond B; College of Physicians & Surgeons, Columbia University at Harlem; Hospital Center, Department of Pediatrics, New York, NY 10037, USA.; PURPOSE: To examine the relationship of reported condom use to specific sociodemographics, psychosocial variables, and perceptions of and motivations for condom use as conceptualized by the Health Belief Model. METHODS: This study performed a cross-sectional survey of 557 adolescents enrolled in a hospital-based pregn
Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome.: Cytokine. 1997 Oct;9(10):781-6. Unique Identifier : AIDSLINE MED/98008088; Toki S; Hiromatsu K; Aoki Y; Makino M; Yoshikai Y; Laboratory of Host Defense, Research Institute for Disease Mechanism; and Control, Nagoya University School of Medicine, Nagoya, Japan.; Mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) were hypersensitive to lipopolysaccharide LPS)-induced lethal shock accompanied by marked elevations of systematic interleukin 1beta (IL-beta) and interferon gamma IFN-gamma) after LPS challenge. Pretreatment with 10 microg of recombinant h
Demodicidosis in immunocompetent young children: report of eight cases.: Dermatology. 1997;195(3):239-42. Unique Identifier : AIDSLINE MED/98071049; Patrizi A; Neri I; Chieregato C; Misciali M; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; Demodex folliculorum and Demodex brevis are obligate parasites of the human pilosebaceous unit. They are the most common permanent ectoparasites in adults, but their incidence on children s skin is rare. Only few cases of demodicidosis have been reported in children aged below 5 years and most of them were suffering f
Early ritonavir-induced maculopapular eruption.: Dermatology. 1997;195(3):301-2. Unique Identifier : AIDSLINE MED/98071067; Bachmeyer C; Blum L; Cordier F; Launay E; Danne O; Aractingi S; Mougeot-Martin M; Departement de Medecine Interne, Centre Hospitalier Laennec, Creil,; France.; We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor. In the 1st patient, clinical improvement occurred despite continuation of therapy, and in the 2nd the treatment was stopped with
Rifabutin-associated uveitis.: Ann Pharmacother. 1997 Nov;31(11):1405. Unique Identifier : AIDSLINE MED/98053189; Saran BR; Chester County Eye Care Associates, West Chester, PA 19380, USA.
Hypertension exacerbated by amphotericin B administration [letter]: Ann Pharmacother. 1997 Nov;31(11):1407-8. Unique Identifier : AIDSLINE MED/98053191; Ferreira E; Perreault MM
Experience with 100 consecutive central venous access arm ports placed by interventional radiologists.: J Vasc Interv Radiol. 1997 Nov-Dec;8(6):983-9. Unique Identifier : AIDSLINE MED/98060388; Hills JR; Cardella JF; Cardella K; Waybill PN; Department of Radiology, The Pennsylvania State University Hospital,; Hershey 17033, USA.; PURPOSE: This study reports the authors experience with long-term follow-up of 100 consecutive peripherally inserted, subcutaneous arm ports for central venous access. MATERIALS AND METHODS: One hundred patients with subcutaneous arm ports inserted by interventional radiologists were retrospectively studied. Data wer
[The effects of small dosage inactivated BCG vaccine on cellular immune function of pulmonary chronic obstructive disease patients with deficiency of lung-qi]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1996 Jul;16(7):408-10. Unique Identifier : AIDSLINE MED/98048981; Zhao X; Xu L; Hu MX; Zhejiang Provincial People's Hospital, Hangzhou.; To investigate the effects of the small dosage inactivated BCG vaccine on the cellular immune function of the patients suffered from pulmonary chronic obstructive disease with deficiency of the Lung-Qi, the authors observed the patients immune function before and after BCG treatment for half a year. RESULTS: The peri
[Effect of fuzheng huayu recipe in treating posthepatitic cirrhosis]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1996 Aug;16(8):459-62. Unique Identifier : AIDSLINE MED/98048991; Liu P; Liu C; Hu YY; Liver Disease Research Center, Shanghai Academy of TCM.; This article deals with the effect of Fuzheng Huayu recipe FZHYR), composed of Semen Persicae, Cordyceps, Radix Salviae Miltiorrhizae, Pollen pini, etc. in treating posthepatitic cirrhosis. 40 patients treated with FZHYR were observed, and another 40 patients in simila condition treated with symptomatic therapy were t
Aspects of HIV infection: current infection control policies for HIV.: Monaldi Arch Chest Dis. 1997 Aug;52(4):371-5. Unique Identifier : AIDSLINE MED/98064670; Mitchell DM; St Mary's Hospital, London, UK.; A coherent infection control policy within healthcare facilities designed for patients with human immunodeficiency virus (HIV) infection requires the application of a risk management strategy. The central feature is the adoption of universal precautions whereby it is assumed that all patients could potentially be infe
Human immunodeficiency virus infection and rheumatic disease.: Bull Rheum Dis. 1997 Dec;46(8):2-5. Unique Identifier : AIDSLINE MED/98073451; Calabrese LH; Department of Rheumatic and Immunologic Diseases, Cleveland Clinic; Foundation, OH, USA.
Automated microanalysis using magnetic beads with commercial capillary electrophoretic instrumentation.: J Chromatogr A. 1997 Sep 26;781(1-2):197-204. Unique Identifier : AIDSLINE MED/98034756; Rashkovetsky LG; Lyubarskaya YV; Foret F; Hughes DE; Karger BL; Barnett Institute, Northeastern University, Boston, MA 02115, USA.; The potential of a new microanalytical method using magnetic beads (MBs) and commercial capillary electrophoresis (CE) instrumentation for performing enzymatic and inhibition assays, as well as for analysis of biological molecules such as antigens, substrates, etc., has been explored. A small quantity of magnetic bead
Expression of a gene for a protein similar to HIV-1 Tat binding protein 1 (TBP1) in floral organs of Brassica rapa.: Plant Cell Physiol. 1997 Aug;38(8):966-9. Unique Identifier : AIDSLINE MED/97468506; Kitashiba H; Toriyama K; Faculty of Agriculture, Tohoku University, Sendai, Japan.; A cDNA for a protein similar to human immunodeficiency virus Tat binding protein was isolated from an anther cDNA library of Brassica rapa. RNA in situ analysis in flower buds showed that the gene for this cDNA was specifically expressed in the tapetum and middle layer of anthers and pollen.
Cytokine mRNA expression in tolerant heart allografts after immunosuppression with cyclosporine, sirolimus or brequinar.: Transpl Immunol. 1997 Sep;5(3):189-98. Unique Identifier : AIDSLINE MED/98066305; Tian L; Stepkowski SM; Qu X; Wang ME; Wang M; Yu J; Kahan BD; Department of Surgery, University of Texas Medical School at Houston,; Texas 77030, USA.; We sought to examine the impact of the preferential activation of Th2 cells on the induction and maintenance of a tolerant state in heart allograft rat recipients treated with a short course of cyclosporine (CsA), sirolimus (SRL) or brequinar (BQR). A quantitative polymerase chain reaction (PCR) method was used to mea
Interleukin-12 p40 m-RNA expression in human kidney allograft biopsies.: Transpl Immunol. 1997 Sep;5(3):199-203. Unique Identifier : AIDSLINE MED/98066306; de Mattos AM; Meyer MM; Norman DJ; Bennett WM; Sprague J; Bakke AC; Laboratory of Immunogenetics and Transplantation, Oregon Health; Sciences University, Portland 97201, USA.; Interleukin-12 (IL-12) is a heterodimeric cytokine implicated in the early differentiation of naive T-lymphocytes into the Th1 subset. IL-12 is important for induction of the cellular immune response against viruses, intracellular parasites and neoplasms. Its role in alloresponsiveness has not been fully elucidated. P
Single dose anti-CD4 monoclonal antibody for induction of tolerance to cardiac allograft in high- and low-responder rat strain combinations.: Transpl Immunol. 1997 Sep;5(3):204-11. Unique Identifier : AIDSLINE MED/98066307; Qi Z; Riesbeck K; Ostraat O; Tufveson G; Ekberg H; Department of Experimental Research, Lund University, University; Hospital, Malmo, Sweden.; Repeated administration of monoclonal antibodies (mAb) directed against the CD4 lymphocyte receptor may induce specific, long-lasting unresponsiveness to fully MHC-mismatched cardiac allografts in rats without additional immunosuppression. We assessed the effect of a single dose of murine anti-rat depleting anti-CD4 m
Pre-AIDS deaths in HIV infection related to intravenous drug use.: QJM. 1997 Oct;90(10):617-29. Unique Identifier : AIDSLINE MED/98077051; Brettle RP; Chiswick A; Bell J; Busuttil A; Wilson A; Povey S; Leen CL; Regional Infectious Disease Unit, City Hospital, Edinburgh, UK.; We prospectively collected data on deaths in the Edinburgh City Hospital HIV cohort of patients (60-70% acquired via injection drug use) from October 1986 to September 1994. Sixty-four patients (25% of all HIV deaths or 2.5/100 person-years) had died without an AIDS diagnosis, and 42 (66%) of these had autopsy data av
Somatropin for treating AIDS-related wasting syndrome.: Am J Health Syst Pharm. 1997 Nov 15;54(22):2618-20. Unique Identifier : AIDSLINE MED/98059617; Kakuda TN; Pharmacy Department, Warren G. Magnuson Clinical Center, National; Institutes of Health, Bethesda, MD, USA.
New guidelines address pediatric issues in antiretroviral therapy [news]: Am J Health Syst Pharm. 1997 Dec 1;54(23):2652. Unique Identifier : AIDSLINE MED/98072784
Major depressive disorder with delusion of having AIDS: a case report.: Chung Hua I Hsueh Tsa Chih (Taipei). 1997 Sep;60(3):173-5. Unique Identifier : AIDSLINE MED/98081351; Yang CH; Lee YC; Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan,; R.O.C.; Acquired immune deficiency syndrome (AIDS) has become a topic of increasing public concern. Several conditions have been described in patients who are afraid that they have acquired AIDS, including depression, somatization disorders, hypochondriasis, adjustment disorders and various psychoses. This paper presents a ca
[HIV/AIDS can weaken a country's economy (news)]: Tidsskr Sykepl. 1997 Nov 25;85(20):46. Unique Identifier : AIDSLINE MED/98093182
[Russia--HIV-infected persons prisoners in concentration camps news)]: Tidsskr Sykepl. 1997 Dec 9;85(21):41. Unique Identifier : AIDSLINE MED/98093198
Intestinal disease in acquired immunodeficiency: evaluation by CT.: Eur Radiol. 1997;7(9):1419-29. Unique Identifier : AIDSLINE MED/98039110; Knollmann FD; Grunewald T; Adler A; Maurer J; Hintze RE; Pohle HD; Felix R; Strahlenklinik und Poliklinik, Virchow-Klinikum, Medizinische Fakultat; der Humboldt-Universitat, Augustenburger Platz 1, D-13 353 Berlin,; Germany.; Intestinal symptoms affect most AIDS patients at some point in their disease. The purpose of this study was to evaluate the use of CT in this setting. A total of 339 abdominal CT exams were reviewed for signs of intestinal disease. Abdominal CT scans of 45 patients with intestinal symptoms were compared with colonosco
Non-Hodgkin's lymphoma.: Curr Opin Hematol. 1995 Jul;2(4):255-61. Unique Identifier : AIDSLINE MED/98039274; Maloney DG; Division of Clinical Research, Fred Hutchinson Cancer Research Center,; Seattle, WA 98104, USA.; The incidence of non-Hodgkin s lymphoma continues to rise. Molecular events in lymphocytes from individuals without lymphoma are found with increasing age and may represent early changes toward malignant transformation. Molecular, immunophenotypic, and histologic data have been use
Strategies for viral inactivation.: Curr Opin Hematol. 1995 Nov;2(6):484-92. Unique Identifier : AIDSLINE MED/98039309; Horowitz B; Ben-Hur E; Melville Biologics, New York, USA.; The risk of transmission of viruses and other pathogenic organisms by blood can be reduced but not eliminated through donor selection and screening methodologies. The safety of blood derivatives prepared from plasma pools from thousands of donors requires virus inactivation, without which transmission rates approach c
Small bowel review: Part II.: Can J Gastroenterol. 1997 Oct;11(7):607-18. Unique Identifier : AIDSLINE MED/98057503; Thomson AB; Wild G; Department of Medicine, University of Alberta, Edmonton.; alan.thomson@ualberta.ca; Significant advances have been made in the study of the small bowel. Part II of this two-part review of the small bowel examines the early development and later ageing of the small bowel; the effect of diabetes, alcohol, radiation and HIV on the small bowel; enteral and parenteral nutrition; the brush border membrane
Tumor-infiltrating lymphocytes in patients with metastatic melanoma receiving chemoimmunotherapy.: J Immunother. 1997 Nov;20(6):488-95. Unique Identifier : AIDSLINE MED/98073920; Hernberg M; Turunen JP; Muhonen T; Pyrhonen S; Department of Oncology, Helsinki University Central Hospital, Finland.; Biopsies from 12 patients with progressive metastatic melanoma were excised during chemoimmunotherapy to evaluate and characterize the local immune response in situ in the metastases. These findings were compared with the distribution of lymphocyte subsets in the peripheral blood and correlated with the clinical data.
One step forward, two steps back.: CMAJ. 1997 Dec 15;157(12):1699-700. Unique Identifier : AIDSLINE MED/98079888; Strathdee SA; Schechter MT; Department of Health Care and Epidemiology, University of British; Columbia, Vancouver.
Tuberculosis infection and disease among persons seeking social services in New York City.: Int J Tuberc Lung Dis. 1997 Feb;1(1):31-7. Unique Identifier : AIDSLINE MED/98059447; Schluger NW; Huberman R; Wolinsky N; Dooley R; Rom WN; Holzman RS; Department of Medicine, New York University School of Medicine, USA.; SETTING: A large public hospital in New York City. OBJECTIVE: To determine the prevalence of tuberculosis infection and disease in a cohort of indigent persons in New York. DESIGN: Persons seeking social services at any of five community-based organizations in New York City were screened for tuberculosis infection usi
Tuberculosis and human immunodeficiency virus infection in west Burkina Faso: clinical presentation and clinical evolution.: Int J Tuberc Lung Dis. 1997 Feb;1(1):68-74. Unique Identifier : AIDSLINE MED/98059453; Malkin JE; Prazuck T; Simonnet F; Yameogo M; Rochereau A; Ayeroue J; Masson D; Lafaix C; Universite Paris XII, Service des Maladies Infectieuses, Centre; Hospitalier, Villeneuve Saint Georges, France.; OBJECTIVE: To study the relationship between human immunodeficiency virus (HIV) infection and tuberculosis (TB) in a West African country. DESIGN: A cohort study in TB patients at the TB centre of Bobo Dioulasso, Burkina Faso . RESULTS: HIV seroprevalence rose from 12.5% in 1987 to
Isolation of environmental mycobacteria from clinical specimens in south-east England: 1973-1993.: Int J Tuberc Lung Dis. 1997 Feb;1(1):75-80. Unique Identifier : AIDSLINE MED/98059454; Yates MD; Pozniak A; Uttley AH; Clarke R; Grange JM; Public Health Laboratory, Dulwich Public Health Laboratory, Dulwich; Hospital, London, UK.; SETTING: A reference centre for tuberculosis bacteriology serving South-East England. OBJECTIVE: The number of cultures of environmental mycobacteria (EM) submitted to regional and reference laboratories in the UK is increasing, and is adding considerably to the workload of these laboratories. The changing trends in t
Survival of human immunodeficiency virus-infected persons with pulmonary tuberculosis [letter]: Int J Tuberc Lung Dis. 1997 Feb;1(1):87. Unique Identifier : AIDSLINE MED/98059457; Wood R; Post FA
Pulmonary clofazimine crystals in two patients with the acquired immunodeficiency syndrome [letter]: Int J Tuberc Lung Dis. 1997 Feb;1(1):88-9. Unique Identifier : AIDSLINE MED/98059458; Alfandari S; Chidiac C; Guery B; Senneville E; Mouton Y; Vinocour D
Initial resistance to antituberculosis drugs in Yaounde, Cameroon in 1995.: Int J Tuberc Lung Dis. 1997 Apr;1(2):110-4. Unique Identifier : AIDSLINE MED/98059465; Bercion R; Kuaban C; Centre Pasteur du Cameroun, Yaounde, Cameroon.; SETTING: Tuberculosis centre of Hopital Jamot, Yaounde, Cameroon , the sole referral and tuberculosis treatment facility for Yaounde and its surroundings. OBJECTIVES: To identify Mycobacterium tuberculosis complex strains responsible for pulmonary tuberculosis in Yaounde, determin
A city-wide outbreak of a multiple-drug-resistant strain of Mycobacterium tuberculosis in New York.: Int J Tuberc Lung Dis. 1997 Apr;1(2):115-21. Unique Identifier : AIDSLINE MED/98059466; Moss AR; Alland D; Telzak E; Hewlett D Jr; Sharp V; Chiliade P; LaBombardi V; Kabus D; Hanna B; Palumbo L; Brudney K; Weltman A; Stoeckle K; Chirgwin K; Simberkoff M; Moghazeh S; Eisner W; Lutfey M; Kreiswirth B; Department of Epidemiology and Biostatistics, University of; California, San Francisco 94143-1347, USA.; SETTING: Incident patients with active tuberculosis (TB) resistant to two or more drugs in New York City hospitals in 1992. OBJECTIVE: To examine the New York-wide distribution of Public Health Research Institute (PHRI) strain W of Mycobacterium tuberculosis, an extremely drug-resistant strain identified by a 17-band
Two-step tuberculin skin testing of injection drug users recruited from community-based settings.: Int J Tuberc Lung Dis. 1997 Apr;1(2):128-34. Unique Identifier : AIDSLINE MED/98059468; Lifson AR; Grant SM; Lorvick J; Pinto FD; He H; Thompson S; Keudell EG; Stark MJ; Booth RE; Watters JK; Division of Epidemiology, University of Minnesota, Minneapolis 55424,; USA. lifson@epivax.epi.umn.edu; SETTING: Cross-sectional study of drug users recruited from street-based settings in four US cities: Denver, Portland, Oakland and San Francisco. OBJECTIVE: To evaluate responses to two-step tuberculin skin testing among HIV-positive and HIV-negative injection drug users. DESIGN: Subjects were recruited from existing
The tuberculosis program of Catalonia's Central Health Region 1986-1993).: Int J Tuberc Lung Dis. 1997 Apr;1(2):142-6. Unique Identifier : AIDSLINE MED/98059470; Miret-Cuadras P; Gonzalez-Fernandez P; Lopez-Sanmartin JL; Martin-Ramos A; Pina Gutierrez JM; Programa de la tuberculosi de la Regio Sanitaria Centre de Catalunya,; Hospital de Malaities del Torax de Terrassa, Spain.; SETTING: Catalonia s Central Health Region antituberculosis program, which began in 1985. OBJECTIVE: To evaluate the cooperation of health staff and the program s effectiveness after 8 years. METHOD: The following data from the nominal notifications and the expanded case reports were processed: epidemiological, clinic
Does pulmonary tuberculosis change with ageing?: Int J Tuberc Lung Dis. 1997 Apr;1(2):147-51. Unique Identifier : AIDSLINE MED/98059471; Rocha M; Pereira S; Barros H; Seabra J; Servico de Pneumologia, Hospital Joaquim Urbano, Faculdade de Medicina; do Porto, Portugal.; SETTING: In most low prevalence countries, tuberculosis has become a disease of the aged; it has recently been suggested that the elderly may present a specific pattern. OBJECTIVE: To compare clinical, bacteriological and radiological features of pulmonary tuberculosis between young and elderly populations in a high i
Extra-pulmonary tuberculosis: a high frequency in the absence of HIV infection.: Int J Tuberc Lung Dis. 1997 Apr;1(2):159-62. Unique Identifier : AIDSLINE MED/98059473; Cowie RL; Sharpe JW; Tuberculosis Services for Southern Alberta, Calgary, Canada.; SETTING: A tuberculosis centre for the diagnosis, management and control of all tuberculosis in a region in Western Canada with a population of approximately 1.2 million. OBJECTIVE: To measure the proportion of cases of extra-pulmonary tuberculosis in relation to country of birth,
A retrospective comparison of clarithromycin versus rifampin in combination treatment for disseminated Mycobacterium avium complex disease in AIDS: clarithromycin decreases transfusion requirements.: Int J Tuberc Lung Dis. 1997 Apr;1(2):163-9. Unique Identifier : AIDSLINE MED/98059474; Burman WJ; Reves RR; Rietmeijer CA; Cohn DL; Denver Disease Control Service, Denver Health and Hospitals, Colorado,; USA.; SETTING: Urban county medical center. OBJECTIVE: To compare clinical outcomes associated with two treatment regimens for AIDS-associated disseminated Mycobacterium avium complex (DMAC). From 1989 to mid-1992, patients were treated with rifampin, ethambutol, and clofazimine; in mid-1992 clarithromycin replaced rifampin
Association between an early humoral response to Mycobacterium tuberculosis antigens and later development of tuberculosis in human immunodeficiency virus-infected individuals.: Int J Tuberc Lung Dis. 1997 Apr;1(2):170-4. Unique Identifier : AIDSLINE MED/98059475; Cavalcante S; Kritski AL; Ferreira MA; Souza MA; Laszlo A; Werneck-Barroso EB; Fonseca LS; Fundacao FIOCRUZ, UFRJ, Rio de Janeiro, Brazil.; OBJECTIVE: To evaluate the association between an early humoral response to Mycobacterium tuberculosis antigens and the later development of tuberculosis (TB) disease in human immunodeficiency virus (HIV)-infected individuals. METHODS: Using an ELISA test, IgG antibodies against 4 M. tuberculosis antigens--purified pr
Cycloserine-induced Stevens-Johnson syndrome in an AIDS patient with multidrug-resistant tuberculosis.: Int J Tuberc Lung Dis. 1997 Apr;1(2):187-90. Unique Identifier : AIDSLINE MED/98059478; Akula SK; Aruna AS; Johnson JE; Anderson DS; Tulane University School of Medicine, New Orleans, Louisiana, USA.; We report a case of cycloserine-induced Stevens-Johnson syndrome SJS) in a 38-year-old male with the acquired immune deficiency syndrome (AIDS) and multidrug resistant tuberculosis (MDR-TB). The patient developed a cutaneous reaction after 60 days of therapy with ofloxacin, streptomycin (SM), pyrazinamide (PZA), etham
CD4+ T-lymphocytopenia in severe pulmonary tuberculosis without evidence of human immunodeficiency virus infection.: Int J Tuberc Lung Dis. 1997 Oct;1(5):422-6. Unique Identifier : AIDSLINE MED/98059524; Pilheu JA; De Salvo MC; Gonzalez J; Rey D; Elias MC; Ruppi MC; Phthisiopulmonology Division, Dr. Enrique Tornu Hospital, Buenos; Aires, Argentina.; SETTING: A large public hospital in Buenos Aires, Argentina . OBJECTIVE: To determine the number of blood CD4 and CD8 T-lymphocytes in male human immunodeficiency virus (HIV) negative patients with severe pulmonary tuberculosis. DESIGN: Seventeen patients with severe pulmonary tu
Utility of tuberculin and anergy skin testing in predicting tuberculosis infection in human immunodeficiency virus-infected persons in Thailand.: Int J Tuberc Lung Dis. 1997 Oct;1(5):427-34. Unique Identifier : AIDSLINE MED/98059525; Yanai H; Uthaivoravit W; Mastro TD; Limpakarnjanarat K; Sawanpanyalert P; Morrow RH Jr; Nieburg P; Research Institute of Tuberculosis, Tokyo, Japan.; SETTING: Chiang Rai, the northernmost province of Thailand , where extensive human immunodeficiency virus (HIV) transmission has resulted in a rapid increase in tuberculosis. OBJECTIVE: To assess the utility of tuberculin and anergy skin testing to identify latent Mycobacterium tu
Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients.: Int J Tuberc Lung Dis. 1997 Oct;1(5):435-40. Unique Identifier : AIDSLINE MED/98059526; Amicosante M; Richeldi L; Monno L; Cuboni A; Tartoni PL; Angarano G; Orefici G; Saltini C; Department of Medical Sciences, University of Modena, Italy.; SETTING: Human immunodeficiency virus (HIV)-positive patients retrospectively identified at the Hospital of Bari, Italy , with diagnosis of tuberculosis (TB) (n = 30) or non-tuberculous pneumonia (n = 29). Serum samples drawn at the time of diagnosis and one year before. Anti-purifie
Risk factors for adverse drug reactions during thiacetazone treatment of pulmonary tuberculosis in human immunodeficiency virus infected adults.: Int J Tuberc Lung Dis. 1997 Oct;1(5):441-5. Unique Identifier : AIDSLINE MED/98059527; Okwera A; Johnson JL; Vjecha MJ; Wolski K; Whalen CC; Hom D; Huebner R; Mugerwa RD; Ellner JJ; Uganda-Case Western Reserve University Research Collaboration,; Kampala, Uganda.; SETTING: Prospective randomised clinical trial comparing the safety and efficacy of rifampicin- and thiacetazone-containing regimens in human immunodeficiency virus (HIV)-infected adults with pulmonary tuberculosis (TB) at the National Tuberculosis Treatment Centre, Kampala, Uganda
Risk factors for relapse in human immunodeficiency virus type 1 infected adults with pulmonary tuberculosis.: Int J Tuberc Lung Dis. 1997 Oct;1(5):446-53. Unique Identifier : AIDSLINE MED/98059528; Johnson JL; Okwera A; Vjecha MJ; Byekwaso F; Nakibali J; Nyole S; Milberg J; Aisu T; Whalen CC; Mugerwa RD; Ellner JJ; Department of Medicine, Case Western Reserve University School of; Medicine, Cleveland, OH, USA.; SETTING: A study conducted by the Uganda-Case Western Reserve University Research Collaboration in Kampala, Uganda, a country with high incidence rates of tuberculosis (TB) and human immunodeficiency virus type 1 (HIV-1) infection. OBJECTIVE: To assess clinical, microbiologic and radiographic factors associated with r
Activity of KRM 1648 or rifabutin alone or in combination with clarithromycin against Mycobacterium avium complex in human alveolar macrophages.: Int J Tuberc Lung Dis. 1997 Oct;1(5):460-7. Unique Identifier : AIDSLINE MED/98059530; Suzuki K; Tsuyuguchi K; Matsumoto H; Yamamoto T; Hashimoto T; Tanaka E; Amitani R; Kuze F; Department of Infection and Inflammation, Kyoto University, Japan.; ksuzuki@chest.kyoto-u.ac.jp; SETTING: The activity of KRM 1648 (KRM), a new benzoxazinorifamycin, and rifabutin (RBT), alone or in combination with clarithromycin (CLA), was evaluated against Mycobacterium avium complex (MAC) that multiplied in human alveolar macrophages (AM). DESIGN: AM were recovered by bronchoalveolar lavage, incubated in RPMI
Delays in the diagnosis of tuberculosis: a great new cost [letter]: Int J Tuberc Lung Dis. 1997 Oct;1(5):485-6. Unique Identifier : AIDSLINE MED/98059537; Lawn SD; Shattock RJ; Griffin GE
Births and deaths: United States, 1996.: Mon Vital Stat Rep. 1997 Sep 11;46(1 Suppl 2):1-40. Unique Identifier : AIDSLINE MED/98068201; Ventura SJ; Peters KD; Martin JA; Maurer JD; OBJECTIVES: This report presents preliminary data on births and deaths in the United States from the National Center for Health Statistics for 1996. U.S. data are shown by age, race, and Hispanic origin. National and State data on births by marital status, prenatal care, cesarean deliv
Therapeutic applications of catalytic antisense RNAs (ribozymes).: Ciba Found Symp. 1997;209:195-204; discussion 204-6. Unique Identifier : AIDSLINE MED/98044834; Rossi JJ; Department of Molecular Biology, Beckman Research Institute of the; City of Hope, Duarte, CA 91010-3011, USA.; Ribozymes have progressed from an intriguing subject of scientific study to therapeutic agents for the potential treatment of a fatal and devastating viral infection. Despite this rapid road to clinical trials, there are many unexplored avenues that should be examined to improve the intracellular effectiveness of ribo
Lymphocyte subset analysis on frozen whole blood.: Cytometry. 1997 Dec 1;29(4):340-50. Unique Identifier : AIDSLINE MED/98075899; Fiebig EW; Johnson DK; Hirschkorn DF; Knape CC; Webster HK; Lowder J; Busch MP; Irwin Memorial Blood Centers, San Francisco, California 94118, USA.; An approach to perform lymphocyte subset analysis on frozen-thawed whole blood (F/T WB) is described. WB from 24 human immunodeficiency virus type 1 (HIV-1) seropositive individuals and 21 controls was analyzed fresh and after frozen storage (with or without dimethyl sulfoxide) at -80 degrees C, in liquid nitrogen (LN
[HIV home test]: Dtsch Med Wochenschr. 1997 Nov 28;122(48):A8-9. Unique Identifier : AIDSLINE MED/98078163; Schattenfroh S
Pharmacological concentrations of suramin inhibit the binding of alpha2-macroglobulin to its cell-surface receptor.: Eur J Biochem. 1997 Dec 1;250(2):320-5. Unique Identifier : AIDSLINE MED/98088956; Vassiliou G; Heart Research Institute, Camperdown, Sydney, Australia.; gerard.vassiliou@anu.edu.au; Suramin is a polysulfated drug used in the treatment of cancer and AIDS. High concentrations (1 mg/ml) of suramin did not affect the ability of native alpha2-macroglobulin (alpha2M) to inhibit proteinases nor did it prevent conversion of native alpha2M to the fast receptor-binding form. Nevertheless, pharmacological
Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase.: Eur J Biochem. 1997 Dec 1;250(2):559-66. Unique Identifier : AIDSLINE MED/98088986; Konvalinka J; Litera J; Weber J; Vondrasek J; Hradilek M; Soucek M; Pichova I; Majer P; Strop P; Sedlacek J; Heuser AM; Kottler H; Krausslich HG; Institute of Organic Chemistry and Biochemistry, Academy of Science of; the Czech Republic, Praha. konval@uochb.cas.cz; Human immunodeficiency virus (HIV) proteinase (PR) represents an important target for antiviral chemotherapy. We present an analysis of inhibitory activities of a series of pseudopeptide inhibitors of HIV-1 PR. All inhibitors were N-protected tetrapeptides with the scissile bond replaced by a nonhydrolysable hydroxyet
Protective effects of the lipophilic redox conjugate tocopheryl succinyl-ethyl ferulate on HIV replication.: FEBS Lett. 1997 Nov 24;418(1-2):15-8. Unique Identifier : AIDSLINE MED/98074896; Edeas MA; Claise C; Vergnes L; Khalfoun Y; Barthelemy S; Labidalle S; Lindenbaum A; Departement de Biochimie, Hopital Antoine Beclere, Clamart, France.; Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds (O-tocopheryl succinyl O-ethyl ferulate) can increase HIV inhibition. We show here for the first time that O-tocopheryl succinyl O-ethyl ferulate inhibits 80%
c-Rel and p65 subunits bind to an upstream NF-kappaB site in human granulocyte macrophage-colony stimulating factor promoter involved in phorbol ester response in 5637 cells.: FEBS Lett. 1997 Nov 24;418(1-2):215-8. Unique Identifier : AIDSLINE MED/98074940; Ghiorzo P; Musso M; Mantelli M; Garre C; Ravazzolo R; Bianchi-Scarra G; Institute of Biology and Genetics, University of Genoa, Italy.; vanceci@unige.it; To further clarify the complex transcriptional regulation of the human GM-CSF gene, which was extensively investigated in activated T cells, we have studied the role of an upstream NF-kappaB like site in the 5637 non-lymphoid cell line, which derives from a bladder carcinoma and constitutively produces GM-CSF. This se
Oral insulin for diabetes prevention in NOD mice: potentiation by enhancing Th2 cytokine expression in the gut through bacterial adjuvant.: Diabetologia. 1997 Aug;40(8):902-9. Unique Identifier : AIDSLINE MED/97411871; Hartmann B; Bellmann K; Ghiea I; Kleemann R; Kolb H; Clinical Department, Diabetes Research Institute at the; Heinrich-Heine-University of Dusseldorf, Germany.; Oral administration of insulin suppresses the development of diabetes in nonobese diabetic (NOD) mice and deviates the cytokine balance in the islets of Langerhans from a Th1 to a Th2 type cytokine pattern. However, the effect of oral insulin is limited and disease suppression is limited to a narrow dose range. Theref
Remission of hairy cell leukemia without treatment.: Haematologia (Budap). 1997;28(4):259-64. Unique Identifier : AIDSLINE MED/98073069; Abramson N; Castro S; Baptist Regional Cancer Institute, Baptist Medical Center,; Jacksonville, FL 32207, USA.; A patient is described with hairy cell leukemia, in whom a remission occurred spontaneously or in association with Legionnaires or subsequent HIV infection. Possible pathophysiological mechanisms are reviewed. Currently it is seventeen years since the diagnosis of hairy cell leukemia and fourteen years since the infus
Self-esteem instability and its implications for HIV prevention among gay men.: Health Soc Work. 1997 Nov;22(4):264-73. Unique Identifier : AIDSLINE MED/98073074; Martin JI; Knox J; Ehrenkranz School of Social Work, New York University, NY 10003, USA.; james.martin@nyu.edu; This study, using a modified State Self-Esteem Scale (SSES), examined self-esteem instability and its association with risky sexual behavior among 455 gay and bisexual men. A self-administered questionnaire included the SSES and measures of intimacy, loneliness, social support, and ways of coping. Analysis of variance
Diagnosis of biliary ductopaenia.: Histopathology. 1997 Nov;31(5):397-9. Unique Identifier : AIDSLINE MED/98078438; Goldin RD; Imperial College School of Medicine at St Mary's, London, UK.
Oxidants, antioxidants and diseases--a brief review.: Indian J Med Sci. 1997 Jul;51(7):226-30. Unique Identifier : AIDSLINE MED/98064498; Singh K; Department of Physiology, Pt. B.D. Sharma PGIMS, Haryana.; Although oxygen (O2) is needed to the body, partially reduced forms of O2 and some of their derivatives collectively called reactive oxygen species (ROS), are highly toxic prooxidants to the body. To prevent ROS toxicity body s endogenous and exogenous antioxidants (AOS) act in concert. To maintain health a balance be
Intrafamilial transmission of HTLV-I and its association with anti-Tax antibody in an endemic population in Japan.: Int J Cancer. 1998 Jan 5;75(1):15-8. Unique Identifier : AIDSLINE MED/98088090; Shioiri S; Stuver SO; Okayama A; Murai K; Shima T; Tachibana N; Tsubouchi H; Essex M; Mueller N; Second Department of Internal Medicine, Miyazaki Medical College,; Japan.; To assess the relationship of anti-Tax antibody to human T-cell lymphotropic virus type-I (HTLV-I) transmission, the sero-prevalence of HTLV-I was analyzed among married couples and among mother/child (both adults) pairs. HTLV-I seroprevalence was significantly higher among wives with anti-Tax+ than those with anti-Ta
T cells in the uninjected eye after anterior chamber inoculation of herpes simplex virus type 1.: Invest Ophthalmol Vis Sci. 1998 Jan;39(1):78-83. Unique Identifier : AIDSLINE MED/98090413; Azumi A; Atherton SS; Department of Cellular and Structural Biology, The University of Texas; Health Science Center, San Antonio 78284-7762, USA.; PURPOSE: To investigate T cell infiltration in the posterior segment of the uninjected eye after uniocular anterior chamber inoculation of HSV-1. METHODS: The anterior chamber of one eye of euthymic BALB/c mice was injected with 1 x 10(4) plaque-forming units (PFU) to 2 x 10(4) PFU of herpes simplex virus type 1 HSV-1
Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.: J Biol Chem. 1997 Dec 19;272(51):32078-83. Unique Identifier : AIDSLINE MED/98070370; Nibbs RJ; Wylie SM; Yang J; Landau NR; Graham GJ; Beatson Institute for Cancer Research, Cancer Research Campaign; Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden,; Glasgow G61 1BD, United Kingdom.; Members of the chemokine family of chemotactic peptides interact with their target cells through heptahelical cell surface receptors. An understanding of the biochemistry and expression patterns of these receptors is therefore central to our overall understanding of the roles played by chemokines in both physiological
Identification of a cellular protein that binds to Tat-responsive element of TGF beta-1 promoter in glial cells.: J Cell Biochem. 1997 Dec 15;67(4):466-77. Unique Identifier : AIDSLINE MED/98044963; Thatikunta P; Sawaya BE; Denisova L; Cole C; Yusibova G; Johnson EM; Khalili K; Amini S; Department of Neurology, Allegheny University of the Health Sciences,; Philadelphia, Pennsylvania 19102, USA.; Tat is a transcriptional transactivator produced by the human immunodeficiency virus type 1 (HIV-1) and plays a pivotal role in enhancing expression of the viral genome in the infected cells. Although initial studies have suggested that interaction of Tat with the transactivation responsive element (TAR); located with
Periungual erythema in HIV-infected patients [letter]: J Am Acad Dermatol. 1997 Dec;37(6):1018-9. Unique Identifier : AIDSLINE MED/98080006; Ruiz-Avila P; Tercedor J; Rodenas JM
Triage decisions for intensive care in terminally ill patients [editorial]: Intensive Care Med. 1997 Oct;23(10):1011-4. Unique Identifier : AIDSLINE MED/98071125; Sprung CL; Eidelman
Septic shock in patients with the acquired immunodeficiency syndrome.: Intensive Care Med. 1997 Oct;23(10):1018-23. Unique Identifier : AIDSLINE MED/98071127; Thyrault M; Gachot B; Chastang C; Souweine B; Timsit JF; Bedos JP; Regnier B; Wolff M; Infectious Diseases Department, Bichat-Claude Bernard Hospital, Paris,; France.; OBJECTIVE: To evaluate the prognosis of patients with septic shock admitted to an intensive care unit (ICU), according to their HIV serostatus. DESIGN: Retrospective study. SETTING: Medical ICU of a university hospital. PATIENTS: 76 patients with septic shock admitted to the same ICU, of whom 28 were HIV positive and
The Pledge Allegiance Generation [editorial]: J Am Dent Assoc. 1997 Dec;128(12):1616, 1618, 1620. Unique Identifier : AIDSLINE MED/98077592; Meskin LH
HIV in the neonate.: J Hosp Infect. 1997 Nov;37(3):181-98. Unique Identifier : AIDSLINE MED/98083548; Gray J; Department of Microbiology, Birmingham Children's Hospital, Ladywood,; UK.; Mother-to-infant transmission of human immunodeficiency virus HIV) is a worldwide problem. Between 7 and 40% of infants born to HIV-positive mothers become infected. The prognosis of these infants is poor, with most developing early and rapidly progressive disease. A number of advances in diagnosis and therapy offer o
Prevention of transmission of tuberculosis in hospitals; a survey of practices in Belgium, 1995.: J Hosp Infect. 1997 Nov;37(3):207-15. Unique Identifier : AIDSLINE MED/98083550; Ronveaux O; Jans B; Wanlin M; Uydebrouck M; Institute of Hygiene and Epidemiology, Brussels, Belgium.; In July 1995, a questionnaire survey was made of nosocomial tuberculosis (TB) prevention practices in Belgian hospitals. Of 122 respondents (response rate: 64%), 93% had hospitalized at least one TB patient, and 11% at least one multi-resistant TB case, during 1994. Effective prevention measures were not uniformly app
Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals.: J Invest Dermatol. 1998 Jan;110(1):62-6. Unique Identifier : AIDSLINE MED/98084705; Hertl M; Amagai M; Sundaram H; Stanley J; Ishii K; Katz SI; Dermatology Branch, National Cancer Institute, Bethesda, Maryland,; USA.; Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and is caused by autoantibodies against desmoglein 3 Dsg3) on epidermal keratinocytes. Because the production of autoantibodies is presumably T cell dependent, Dsg3-specific T cell reactivity was investigated in 14 PV patients and 12 healthy donor
Increase in neutralizing antibody titer against sequential autologous HIV-1 isolates after 16 weeks saquinavir (Invirase) treatment.: J Med Virol. 1997 Dec;53(4):313-8. Unique Identifier : AIDSLINE MED/98071268; Sarmati L; Nicastri E; el-Sawaf G; Ventura L; Salanitro A; Ercoli L; Vella S; Andreoni M; Department of Public Health and Cellular Biology, University of Rome; Tor Vergata, Italy.; The humoral immune response to HIV infection plays an important role in determining disease progression. Few and discordant results correlate changes in neutralizing antibody (NtAb) titer with antiretroviral treatment. The NtAb titer against autologous-HIV was evaluated in 33 patients treated with the protease inhibit
Analysis of HIV seropositive thalassemic children for antibodies specific to Aspergillus fumigatus by luminescent immunoassay.: J Clin Lab Anal. 1997;11(6):343-5. Unique Identifier : AIDSLINE MED/98069128; Sharma GL; Bhatnagar PK; Chattopadhya D; Sarma PU; Centre for Biochemical Technology, Delhi, India.; The applicability of luminescent immunoassay (LIA) in serodiagnosis of fungal infections in multitransfused (MT) thalassemic children seropositive for human immunodeficiency virus (HIV) was investigated. Thirty-one sera samples from HIV infected pediatric patients with thalassemia receiving repeated blood transfusions
Incidence of premature birth and neonatal respiratory disease in infants of HIV-positive mothers. The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Infection Study Group.: J Pediatr. 1997 Dec;131(6):851-6. Unique Identifier : AIDSLINE MED/98089358; Martin R; Boyer P; Hammill H; Peavy H; Platzker A; Settlage R; Shah A; Sperling R; Tuomala R; Wu M; Case Western Reserve University, Cleveland, Ohio, USA.; OBJECTIVE: We sought to determine the prematurity rate in infants of HIV-positive mothers and to characterize the incidence and severity of neonatal respiratory disease in this population. STUDY DESIGN: From 1990 to 1994, 600 live-born infants of HIV-infected mothers were enrolled prenatally (73%) or postnatally (27%)
Acceptability and impact of zidovudine for prevention of mother-to-child human immunodeficiency virus-1 transmission in France.: J Pediatr. 1997 Dec;131(6):857-62. Unique Identifier : AIDSLINE MED/98089359; Mayaux MJ; Teglas JP; Mandelbrot L; Berrebi A; Gallais H; Matheron S; Ciraru-Vigneron N; Parnet-Mathieu F; Bongain A; Rouzioux C; Delfraissy JF; Blanche S; Institut National de la Sante et la Recherche Medicale (INSERM) Unite; 292 Hopital Bicetre, Le Kremlin Bicetre, France.; We studied the propagation and the impact of zidovudine prevention on the human immunodeficiency virus-1 transmission rate from infected mothers to their infants in the French nationwide prospective cohort. Infection was diagnosed in the children on the basis of at least two positive human immunodeficiency virus-1 pol
Selective phage infection mediated by epitope expression on F pilus.: J Mol Biol. 1997 Oct 31;273(3):544-51. Unique Identifier : AIDSLINE MED/98022901; Malmborg AC; Soderlind E; Frost L; Borrebaeck CA; Department of Immunotechnology, Lund University, Sweden.; Proteins and peptides can be displayed on bacterial and bacteriophage surfaces as fusions to bacterial integral membrane proteins or phage coat proteins. We now report on the expression of peptide antigens on the surface of F pili, elaborated by F+ strains of Escherichia coli. The peptides were expressed as fusions to
[Chronic enteropathy of unknown etiology in patients with AIDS. An analysis of 40 cases]: Med Clin (Barc). 1997 Oct 11;109(12):452-6. Unique Identifier : AIDSLINE MED/98023303; Moreno Camacho A; Moreno Martinez A; Valls ME; Bordas JM; Pique JM; Bombi JA; Miro JM; Mallolas J; Gatell JM; Soriano E; Servicios de Enfermedades infecciosas, Hospital Clinic i Provincial,; Facultad de Medicina, Universidad de Barcelona.; BACKGROUND: Data about the etiology of chronic enteropathy in AIDS patients are scarce and are very dependent upon the geographical area. The aim of this study was to detect microorganisms potentially associated with chronic enteropathy in AIDS patients with diarrhoea for more than one month, and initial negative rout
Nosocomial transmission of Mycobacterium bovis resistant to 11 drugs in people with advanced HIV-1 infection.: Lancet. 1997 Dec 13;350(9093):1738-42. Unique Identifier : AIDSLINE MED/98075386; Guerrero A; Cobo J; Fortun J; Navas E; Quereda C; Asensio A; Canon J; Blazquez J; Gomez-Mampaso E; Infectious Disease and Clinical Microbiology Department, Hospital; Ramon y Cajal, Universidad de Alcala de Henares, Madrid, Spain.; antonio.guerrero@hrc.es; BACKGROUND: Since 1990, several nosocomial outbreaks of multidrug-resistant (MDR) tuberculosis have occurred, none of which have involved Mycobacterium bovis. We describe an epidemic of nosocomial and primary MDR M bovis tuberculosis from December, 1993, to February, 1995, among HIV-1-infected patients in a district o
HIV-1 infection puzzles Denmark [news]: Lancet. 1997 Dec 13;350(9093):1758. Unique Identifier : AIDSLINE MED/98075397; Skovmand K
Antiretrovirals planned for developing world [news]: Lancet. 1997 Dec 13;350(9093):1759. Unique Identifier : AIDSLINE MED/98075398; Feinmann J
US admits defeat on HIV drugs [news]: Lancet. 1997 Dec 13;350(9093):1759. Unique Identifier : AIDSLINE MED/98075399; Rovner J
HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis [letter]: Lancet. 1997 Dec 13;350(9093):1780. Unique Identifier : AIDSLINE MED/98075413; Gray RH; Wawer MJ; Sewankambo N; Serwadda D
Antenatal HIV testing in Europe [letter]: Lancet. 1997 Dec 13;350(9093):1783. Unique Identifier : AIDSLINE MED/98075419; Hudson CN; Sherr L
Transforming growth factor beta stimulates the human immunodeficiency virus 1 enhancer and requires NF-kappaB activity.: Mol Cell Biol. 1998 Jan;18(1):110-21. Unique Identifier : AIDSLINE MED/98078668; Li JM; Shen X; Hu PP; Wang XF; Department of Pharmacology and Cancer Biology, Duke University Medical; Center, Durham, North Carolina 27708, USA.; Transforming growth factor beta (TGF-beta) is the prototype of a large superfamily of signaling molecules involved in the regulation of cell growth and differentiation. In certain patients infected with human immunodeficiency virus type 1 HIV-1), increased levels of TGF-beta promoted the production of virus and also i
A controlled trial of double versus triple therapy for HIV [letter]: N Engl J Med. 1998 Jan 15;338(3):196; discussion 197. Unique Identifier : AIDSLINE MED/98080373; Feldmesser M; Falkenberg J
A controlled trial of double versus triple therapy for HIV [letter]: N Engl J Med. 1998 Jan 15;338(3):196-7; discussion 197. Unique Identifier : AIDSLINE MED/98080374; Arranz Caso JA
A controlled trial of double versus triple therapy for HIV [letter]: N Engl J Med. 1998 Jan 15;338(3):197. Unique Identifier : AIDSLINE MED/98080375; Delgado Fernandez M; Zambrana Garcia JL; Diez Garcia F
Battling HIV on many fronts [letter]: N Engl J Med. 1998 Jan 15;338(3):198. Unique Identifier : AIDSLINE MED/98080376; Adams M; Hanssens C; Lazarus T
Battling HIV on many fronts [letter]: N Engl J Med. 1998 Jan 15;338(3):198. Unique Identifier : AIDSLINE MED/98080377; Horberg M; Schatz B
Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.: Nature. 1998 Jan 8;391(6663):177-81. Unique Identifier : AIDSLINE MED/98089039; Wilson SB; Kent SC; Patton KT; Orban T; Jackson RA; Exley M; Porcelli S; Schatz DA; Atkinson MA; Balk SP; Strominger JL; Hafler DA; Department of Molecular and Cellular Biology, Harvard University,; Cambridge, Massachusetts 02138, USA.; Type 1 diabetes (insulin-dependent diabetes mellitus, IDDM) is a disease controlled by the major histocompatibility complex (MHC) which results from T-cell-mediated destruction of pancreatic beta-cells. The incomplete concordance in identical twins and the presence of autoreactive T cells and autoantibodies in individ
Use of cerebrospinal fluid shunts in patients having acquired immunodeficiency syndrome with cryptococcal meningitis and uncontrollable intracranial hypertension.: Neurosurgery. 1997 Dec;41(6):1280-2; discussion 1282-3. Unique Identifier : AIDSLINE MED/98066199; Bach MC; Tally PW; Godofsky EW; Department of Medicine, Manatee Memorial Hospital, Bradenton, Florida,; USA.; OBJECTIVE: To evaluate the treatment of serious and uncontrollable intracranial hypertension in patients with acquired immunodeficiency syndrome who developed cryptococcal meningitis. METHODS: All cases of cryptococcal meningitis with elevated pressure and acquired immunodeficiency syndrome were reviewed in detail and
Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages.: Neurology. 1997 Dec;49(6):1671-81. Unique Identifier : AIDSLINE MED/98073830; Kerr SJ; Armati PJ; Pemberton LA; Smythe G; Tattam B; Brew BJ; Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW,; Australia.; The AIDS dementia complex (ADC) is a consequence of excessive immune activation driven at least in part by systemic HIV infection and probably brain infection. Quinolinic acid (QUIN) is a neurotoxic tryptophan metabolite produced by macrophages in response to stimulation with cytok
Non-AIDS-related lymphomatous meningitis: combined modality therapy.: Neurology. 1997 Dec;49(6):1728-31. Unique Identifier : AIDSLINE MED/98073846; Chamberlain MC; Kormanik PA; University of California, San Diego, Department of Neurosciences, La; Jolla 92093-8421, USA.; Twenty-two patients (age range, 38 to 69 years; median, 60 years) with lymphomatous meningitis due to metastatic non-AIDS-related non-Hodgkin s lymphoma were treated. Cytologic responses were seen in 16 patients (73%) to first-line chemotherapy, 7 patients 58%) to second-line chemo
Mycobacterium avium complex infection of the paranasal sinuses.: Otolaryngol Head Neck Surg. 1997 Dec;117(6):S160-2. Unique Identifier : AIDSLINE MED/98078944; Ferguson BJ; Kapadia SB; Carrau RL; Department of Otolaryngology-Head and Neck Surgery, University of; Pittsburgh Medical Center, Pennsylvania 15213, USA.
Invasive Pseudallescheria boydii fungal infection of the temporal bone.: Otolaryngol Head Neck Surg. 1997 Dec;117(6):S91-4. Unique Identifier : AIDSLINE MED/98078922; Busaba NY; Poulin M; Department of Otolaryngology, Boston University School of Medicine,; West Roxbury/Brockton VA Medical Center, Massachusetts 02132, USA.
A spermidine-induced conformational change of long-armed hammerhead ribozymes: ionic requirements for fast cleavage kinetics.: Nucleic Acids Res. 1997 Dec 1;25(23):4715-22. Unique Identifier : AIDSLINE MED/98033380; Hammann C; Hormes R; Sczakiel G; Tabler M; Institute of Molecular Biology and Biotechnology, Foundation for; Research and Technology Hellas, PO Box 1527, GR-71110 Heraklion,; Crete, Greece.; The catalytic activity of the trans cleaving hammerhead ribozyme 2as-Rz12, with long antisense flanks of 128 and 278 nt, was tested under a wide range of different reaction conditions for in vitro cleavage of a 422 nt RNA transcript derived from human immunodeficiency virus type 1 (HIV-1). Depending on the reaction co
A comparison of patient and nurse ratings of human immunodeficiency virus-related signs and symptoms.: Nurs Res. 1997 Nov-Dec;46(6):318-23. Unique Identifier : AIDSLINE MED/98083968; Reilly CA; Holzemer WL; Henry SB; Slaughter RE; Portillo CJ; Department of Community Health Systems, School of Nursing, University; of California, San Francisco, USA.; Since management strategies are guided by the assessment of the symptom experience, agreement between patients and nurses perceptions of symptoms is central to clinical management. In this study, acquired immune deficiency syndrome patients perceptions of 41 human immunodeficiency virus-related signs and symptoms w
Oral nutrition for the patient with HIV infection.: Nurs Clin North Am. 1997 Dec;32(4):813-30. Unique Identifier : AIDSLINE MED/98047383; Gerrior JL; Bell SJ; Wanke CA; Division of Infectious Disease, Beth Israel Deaconess Medical Center,; West Campus, Boston, Massachusetts 02215, USA.; In the era of highly active antiretroviral therapy, it is unclear what percentage of patients with HIV infection will develop nutritional issues, including weight loss, diarrheal illness and anorexia. The purpose of this article is to discuss nutritional concerns that can occur with HIV infection and potential treatme
Systemic lupus erythematosus (SLE) lymphadenopathy presenting with histopathologic features of Castleman' disease: a clinicopathologic study of five cases.: Pathol Res Pract. 1997;193(8):565-71. Unique Identifier : AIDSLINE MED/98069324; Kojima M; Nakamura S; Itoh H; Yoshida K; Asano S; Yamane N; Komatsumoto S; Ban S; Joshita T; Suchi T; Department of Pathology, Ashikaga Red Cross Hospital, Japan.; Lymph node enlargement is common in active systemic lupus erythematosus (SLE), a disease characterized by well defined clinical criteria. Although numerous reports have described the characteristic histology of SLE lymphadenopathy to include necrotizing lesions and hematoxylin bodies, no detailed description has exami
Transient expression of a purine-selective nucleoside transporter SPNTint) in a human cell line (HeLa).: Pharm Res. 1997 Oct;14(10):1316-21. Unique Identifier : AIDSLINE MED/98023400; Schaner ME; Wang J; Zevin S; Gerstin KM; Giacomini KM; Department of Biopharmaceutical Sciences, University of California San; Francisco 94143, USA.; PURPOSE: The goal of this study was to develop a mammalian expression system for the cloned rat intestinal, Na(+)-dependent, purine-selective nucleoside transporter (SPNTint) and to study the interactions of nucleosides and nucleoside analogs with this transporter. METHODS: Lipofection was used to transfect HeLa cells
[Role of cellular proteases and protease inhibitor in viral infection]: Tanpakushitsu Kakusan Koso. 1997 Oct;42(14 Suppl):2399-407. Unique Identifier : AIDSLINE MED/98032930; Kido H; Division of Enzyme Chemistry, University of Tokushima, Japan.
[Structural analysis of protease-inhibitor system using graphics]: Tanpakushitsu Kakusan Koso. 1997 Oct;42(14 Suppl):2465-73. Unique Identifier : AIDSLINE MED/98032938; Kiso Y; Department of Medicinal Chemistry, Kyoto Pharmaceutical University,; Japan.
[Changes in epidemiology of opportunistic infections due to Candida]: Rev Clin Esp. 1995 Oct;195 Suppl 3:1-3. Unique Identifier : AIDSLINE MED/98078189; Odds FC; Departamento de Bacteriologia y Micologia, Janssen Research; Foundation, Belgica.
[New aspects of infections caused by Aspergillus and Mucor and other filamentous fungi in immunosuppressed patients]: Rev Clin Esp. 1995 Oct;195 Suppl 3:15-25. Unique Identifier : AIDSLINE MED/98078191; Bouza E; Servicio de Microbiologia Clinica y Enfermedades Infecciosas, General; Universitario Gregorio Maranon, Universidad Complutense, Madrid.
[Treatment of cryptococcosis in patients with acquired immunodeficiency syndrome]: Rev Clin Esp. 1995 Oct;195 Suppl 3:26-30. Unique Identifier : AIDSLINE MED/98078192; Graybill JR; University of Texas, Department of Medicine, Division of Infectious; Diseases, San Antonio, USA.
[Diagnosis, treatment and prevention of infections caused by fungi in HIV-positive patients]: Rev Clin Esp. 1995 Oct;195 Suppl 3:4-14. Unique Identifier : AIDSLINE MED/98078190; Fortun Abete J; Unidad de Enfermedades Infecciosas, Hospital Ramon y Cajal, Madrid.
[Antifungal agent resistance of yeasts of clinical significance]: Rev Clin Esp. 1995 Oct;195 Suppl 3:56-7. Unique Identifier : AIDSLINE MED/98078196; Odds FC; Departamento de Bacteriologia y Micologia, Janssen Research; Foundation, Belgica.
[Itraconazole in systemic fungal infections. Clinical profile and future trends]: Rev Clin Esp. 1995 Oct;195 Suppl 3:66-70. Unique Identifier : AIDSLINE MED/98078198; Fernandez Fernandez A; Esteban Montero S; Departamento Medico Janssen-Cilag, Madrid.
Questions about NOD mouse diabetes.: Res Immunol. 1997 Jun;148(5):286-91. Unique Identifier : AIDSLINE MED/98013887; Cohen IR; Department of Immunology, Weizmann Institute of Science, Rehovot,; Israel.
Immunobiology of autoimmune diabetes.: Res Immunol. 1997 Jun;148(5):313-9. Unique Identifier : AIDSLINE MED/98013891; Lafferty KJ; Division of Molecular Medicine, John Curtin School of Medical; Research, Australian National University, Canberra, Australia.
CD4+ and CD8+ T lymphocytes: clarification of their pathogenic roles in diabetes in the NOD mouse.: Res Immunol. 1997 Jun;148(5):320-7. Unique Identifier : AIDSLINE MED/98013892; Kay TW; Chaplin HL; Parker JL; Stephens LA; Thomas HE; Burnet Clinical Research Unit, Walter and Eliza Hall Institute of; Medical Research, PO Royal Melbourne Hospital, Victoria, Australia.
The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse.: Res Immunol. 1997 Jun;148(5):327-32. Unique Identifier : AIDSLINE MED/98013893; Wong FS; Janeway CA Jr; Section of Immunobiology, Howard Hughes Medical Institute, Yale; University School of Medicine, New Haven, CT 06510, USA.
[AIDS: advantages and disadvantages of double dispensation]: Rev Infirm. 1997 Apr;(26):73-4. Unique Identifier : AIDSLINE MED/97359484; Trabacchi G; Burrus O
[Thrombocytopenia. Diagnostic orientation]: Rev Prat. 1997 Oct 1;47(15):1695-701. Unique Identifier : AIDSLINE MED/98069591; Godeau B; Bierling P; Service de medecine interne, hopital Henri-Mondor, Creteil.
Ultraviolet-induced cell death blocked by a selenoprotein from a human dermatotropic poxvirus [see comments]: Science. 1998 Jan 2;279(5347):102-5. Unique Identifier : AIDSLINE MED/98079173; Shisler JL; Senkevich TG; Berry MJ; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, 4 Center Drive,; MSC 0445, Bethesda, MD 20892-0445, USA.; Selenium, an essential trace element, is a component of prokaryotic and eukaryotic antioxidant proteins. A candidate selenoprotein homologous to glutathione peroxidase was deduced from the sequence of molluscum contagiosum, a poxvirus that causes persistent skin neoplasms in children and acquired immunodeficiency synd
SIV vaccine for AIDS [letter]: Science. 1998 Jan 2;279(5347):14-5. Unique Identifier : AIDSLINE MED/98101367; Farthing CF; Sullivan JL
[The 8th International Conference on drug-related risk reduction]: Soins. 1997 Jan-Feb;(612):33-4. Unique Identifier : AIDSLINE MED/97265099; Coppel A; Clinique Liberte CH Paul Guiraud, Villejuif.
[Rediscovered sense]: Soins. 1997 Jan-Feb;(612):5. Unique Identifier : AIDSLINE MED/97265091; Touzeau D; Arnold-Richez F; Clinique Liberte, CH Paul Guiraud, Villejuif.
[The professional and AIDS]: Soins. 1997 Jun;(616):22-4. Unique Identifier : AIDSLINE MED/97421711; Tolila-Huet Y; hopital de jour, Hopital Bichat-Claude Bernard, Paris.
[Self-support of drug users. Caring]: Soins Psychiatr. 1997 Mar;(189):12-5. Unique Identifier : AIDSLINE MED/97359507; Dard JR; ASUD, Paris.
[Nursing and caring]: Soins Psychiatr. 1997 Mar;(189):5-6. Unique Identifier : AIDSLINE MED/97359505; Touzeau D; Arnold-Richez F; Psychiatre des hopitaux, Clinique Liberte, Centre hospitalier Paul; Guiraud, Villejuif.
[Towards the end of AIDS?]: Tidsskr Nor Laegeforen. 1997 Nov 30;117(29):4203. Unique Identifier : AIDSLINE MED/98087846; Aavitsland P
Increased inducible interleukin-2 receptor expression on CD8 lymphocytes in black recipients of renal allografts with deteriorating function.: Transplant Proc. 1997 Dec;29(8):3713-4. Unique Identifier : AIDSLINE MED/98076576; Modiba MC; Ngcobo TK; Ndlovu S; Viljoen E; Department of General Surgery, Medical University of Southern Africa,; Medunsa, South Africa.
AIDS-related disseminated histoplasmosis in San Francisco, California.: West J Med. 1997 Nov;167(5):315-21. Unique Identifier : AIDSLINE MED/98054689; Fredricks DN; Rojanasthien N; Jacobson MA; Division of Infectious Diseases and Geographic Medicine, Stanford; University Medical Center, California, USA.; The published reports of patients with the acquired immunodeficiency syndrome (AIDS) with disseminated histoplasmosis come mostly from institutions located in endemic areas for histoplasmosis, where disease is thought to occur by either primary infection or reactivation. The characteristics of reactivation disease are
Recommendations for immunizations in HIV-infected individuals.: West J Med. 1997 Nov;167(5):343-4. Unique Identifier : AIDSLINE MED/98054693; Marquardt D
Drug reactions in HIV/AIDS.: West J Med. 1997 Nov;167(5):344. Unique Identifier : AIDSLINE MED/98054694; Hussain H; Beall G; Sanwo M
Combination therapy for HIV disease.: West J Med. 1997 Nov;167(5):346-7. Unique Identifier : AIDSLINE MED/98054697; Frascino RJ
Surgical infections in immunocompromised patients--prevention and treatment.: Adv Surg. 1997;31:299-331. Unique Identifier : AIDSLINE MED/98072779; Kusne S; Shapiro R; Thomas E. Starzl Transplantation Institute, Division of Infectious; Diseases, University of Pittsburgh, Pennsylvania, USA.; The care of immunocompromised patients is a challenge to all physicians. The variety of opportunistic infections that can develop in these patients underscores the importance of the immune response. The key to success in the prevention and management of infections in these patients lies in knowing what kind of infecti
Invited commentary: le mystere de Montreal [comment]: Am J Epidemiol. 1997 Dec 15;146(12):1003-6; discussion 1007-10. Unique Identifier : AIDSLINE MED/98082093; Lurie P; Institute for Social Research, University of Michigan, Ann Arbor; 48106, USA.
High rates of HIV infection among injection drug users participating in needle exchange programs in Montreal: results of a cohort study [see comments]: Am J Epidemiol. 1997 Dec 15;146(12):994-1002. Unique Identifier : AIDSLINE MED/98082092; Bruneau J; Lamothe F; Franco E; Lachance N; Desy M; Soto J; Vincelette J; Department of Psychiatry, University of Montreal, Quebec, Canada.; Needle exchange programs (NEPs) are designed to prevent human immunodeficiency virus (HIV) transmission among injection drug users. Although most studies report beneficial effects in terms of behavior modification, a direct assessment of the effectiveness of NEPs in preventing HIV infection has been lacking. A cohort
Nasal mucosal cell alterations in HIV-infected patients.: Am J Med Sci. 1997 Dec;314(6):365-9. Unique Identifier : AIDSLINE MED/98075261; Lin RY; Clarin E; Lee M; Nahal A; Department of Medicine, St. Vincent's Hospital, New York, NY 10011,; USA.; Patients with HIV infection often have nasopharyngeal symptoms related to inflammatory or infectious diseases of the upper respiratory tract. In this study, we examined specific nasal mucosal cytologic alterations in adult patients with HIV infection for associations with nasopharyngeal symptoms and other clinical par
HIV vaccine acceptance among heterosexual clients of a sexually transmitted diseases clinic.: Am J Med Sci. 1998 Jan;315(1):11-6. Unique Identifier : AIDSLINE MED/98087441; Tello J; Soong SJ; Hunter B; Meriwether R; Hook EW 3rd; Mulligan MJ; University of Alabama at Birmingham, 35294-2170, USA.; We evaluated the willingness of clients at a large urban sexually transmitted diseases (STD) clinic in the southeastern United States to participate in future trials of preventive vaccines for HIV type 1 (HIV-1). A single trained interviewer administered an oral survey instrument to ST
Cervical adenitis due to Mycobacterium fortuitum in patients with acquired immunodeficiency syndrome.: Am J Med Sci. 1998 Jan;315(1):50-5. Unique Identifier : AIDSLINE MED/98087447; Butt AA; Section of Infectious Diseases, Louisiana State University Medical; Center, New Orleans 70112, USA. aabutt@bellsouth.net; Rapidly growing mycobacteria, an infrequent cause of human disease, are increasingly being recognized as human pathogens rather than mere colonizers. Rapidly growing mycobacteria infrequently cause disease in patients with acquired immunodeficiency syndrome (AIDS). It is unclear whether patients with AIDS are more pre
The return of thalidomide: are birth defects surveillance systems ready?: Am J Med Genet. 1997 Dec 19;73(3):251-8. Unique Identifier : AIDSLINE MED/98076161; Yang Q; Khoury MJ; James LM; Olney RS; Paulozzi LJ; Erickson JD; Division of Birth Defects and Developmental Disabilities, National; Center for Environmental Health, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA. qay0@cdc.gov; In the 1960s, thalidomide caused limb deficiencies in thousands of infants worldwide. The limb deficiencies were frequently of the intercalary type. As a result, numerous countries started birth defect surveillance programs. In 1967, the Centers for Disease Control (CDC) started the Metropolitan Atlanta Congenital Def
The in vitro antitumor assay of "half-mustard type" phenothiazines in screens of AIDS-related leukemia and lymphomas.: Anticancer Res. 1997 Sep-Oct;17(5A):3425-9. Unique Identifier : AIDSLINE MED/98074661; Wuonola MA; Palfreyman MG; Motohashi N; Kawase M; Gabay S; Molnar J; SCRIPTGEN Pharmaceuticals, Inc., Medford, MA 02155, USA.; Twelve different half-mustard type phenothiazines were newly synthesized and tested on seven AIDS-related lymphoma (ARL) tumor cell lines, one leukemia CCRF-CEM cell culture and five different lymphoma lines; RL, KD-488, AS283, PA682 and SU-DHL-7 cell lines. The alkylene-urea substituted phenothiazines affected the
Kaposiform hemangioendothelioma. An aggressive, locally invasive vascular tumor that can mimic hemangioma of infancy.: Arch Dermatol. 1997 Dec;133(12):1573-8. Unique Identifier : AIDSLINE MED/98082114; Vin-Christian K; McCalmont TH; Frieden IJ; Department of Dermatology, University of California, San Francisco; 94143, USA.; BACKGROUND: Kaposiform hemangioendothelioma is a rare, aggressive vascular proliferation in children that is clinically and histologically distinct from hemangioma of infancy. It often manifests later than infantile hemangioma, and complication by Kasabach-Merritt syndrome is common. OBSERVATIONS: We examined 3 childr
[Glycyrrhizic acid]: Bioorg Khim. 1997 Sep;23(9):691-709. Unique Identifier : AIDSLINE MED/98010787; Tolstikov GA; Baltina LA; Shul'ts EE; Pokrovskil AG; The specific properties, chemical transformations, and biological activity of glycyrrhizic acid and its derivatives are discussed. Particular attention is paid to investigations that hold promise for the development of important drugs for clinical use.
Outline of the Human Retrovirus Registry: profile of a Puerto Rican HIV infected population.: Bol Asoc Med P R. 1997 Jul-Sep;89(7-9):111-6. Unique Identifier : AIDSLINE MED/98081322; Gomez MA; Velazquez M; Hunter RF; Internal Medicine Department, Universidad Central del Caribe, Bayamon,; P.R. 00960-6032.; OBJECTIVE: To present the general socio-demographic profile, some risk related parameters and elements of the clinical spectrum of disease at presentation, of those HIV/AIDS patients enrolled in the Human Retrovirus Registry. METHODS: This is a prospective longitudinal cohort study, which has been identifying since Ma
HIV/AIDS risk factors among adolescent students in Puerto Rico, 1994.: Bol Asoc Med P R. 1997 Jul-Sep;89(7-9):140-5. Unique Identifier : AIDSLINE MED/98081328; Moscoso MR; Rodriguez-Figueroa L; Parrilla I; Robles R; Colon H; Universidad Central del Caribe, Center for Addictions Study,; Department of Family Medicine, Bayamon, PR 00960-6032.; PURPOSE: Identify several HIV risk behaviors among adolescent students. METHODS: The sample (n = 3,648) was selected using a two-staged stratified cluster sampling design, and weighted to represent all junior high and high school students. RESULTS: About 28.8% of the students reported ever having sexual activity. Less
The biological relevance of polykaryons in the immune response.: Immunol Today. 1997 Nov;18(11):522-7. Unique Identifier : AIDSLINE MED/98047506; Fais S; Burgio VL; Capobianchi MR; Gessani S; Pallone F; Belardelli F; Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.; Peripheral blood monocyte-derived multinucleated giant cells are a well-known feature of chronic inflammatory conditions. Similarly, virus-induced syncytia derived from CD4+ cells are considered to be typical of human immunodeficiency virus infection under culture conditions. Here, Stefano Fais and colleagues summariz
Pre-infection CD4+:CD8+ ratio and HIV infection [letter]: Immunol Today. 1997 Nov;18(11):555-6. Unique Identifier : AIDSLINE MED/98047512; Bostik P; Villinger F; Ansari AA; Folks TM
Long-term resistance to HIV infection in vertical HIV infection: cytokine production, HIV isolation, and HIV phenotype define long-term resistant hosts.: Pathobiology. 1997;65(4):169-76. Unique Identifier : AIDSLINE MED/98057821; Vigano A; Balotta C; Trabattoni D; Bricalli D; Crupi L; Palomba E; Galli L; Salvaggio A; Fusi ML; Ruzzante S; Massironi E; Colombo MC; Principi N; Galli M; Clerici M; Cattedra di Pediatria IV, H.L. Sacco, Universita di Milano, Italia.; We analyzed immunologic (CD4 and CD8 slopes; interferon-gamma, interleukin-2, interleukin-10, and chemokines production; concentration of IgE; beta 2-microglobulin) and virologic (p24; HIV isolability and phenotype; plasma viremia) parameters in HIV vertically infected children > or = 8 years of age without disease pr
HLA-DQB1 markers associated with human immunodeficiency virus type I disease progression.: Pathobiology. 1997;65(4):210-5. Unique Identifier : AIDSLINE MED/98057827; Achord AP; Lewis RE; Brackin MN; Cruse JM; Department of Pathology, University of Mississippi Medical Center,; Jackson 39216-4505, USA.; In a previous investigation, we demonstrated that certain human leukocyte antigens (HLA) may be associated with human immunodeficiency virus type I (HIV-1) infection or protection from infection among regional African Americans and Caucasians. We demonstrated that HLA-DQB1*0605 was associated with a possible increased
Mature CD4 single positive thymocytes in human Thymoma: T cells may differentiate in the thymic epithelial cell tumor.: Pathobiology. 1997;65(4):216-22. Unique Identifier : AIDSLINE MED/98057828; Inoue M; Fujii Y; Okumura M; Takeuchi Y; Shiono H; Miyoshi S; Matsuda H; Shirakura R; Division of Organ Transplantation, Osaka University Medical School,; Japan.; Human thymoma, which is occasionally associated with autoimmune disease, is a thymic epithelial cell tumor and often contains a large number of lymphocytes. In a previous study, we have shown that a proportion of CD4 single positive T cells in human thymomas lack CD3, suggesting immaturity. In this study, we focused o
Global AIDS surveillance. Part II.: Wkly Epidemiol Rec. 1997 Dec 5;72(49):365-8. Unique Identifier : AIDSLINE MED/98087879
Painful day.: Nurs Stand. 1997 Dec 3-9;12(11):19. Unique Identifier : AIDSLINE MED/98093084; McNicholas A
Addition of granulocyte colony-stimulating factor to chemotherapy in patients with AIDS-related lymphoma: effects on neutrophil Fc gamma receptor expression and soluble Fc gammaRIII plasma levels.: Br J Haematol. 1997 Dec;99(3):537-41. Unique Identifier : AIDSLINE MED/98062234; Kersten MJ; de Jong S; Evers LM; Koene HR; van Oers MH; Department of Haematology, Academic Medical Centre, Amsterdam, The; Netherlands.; AIDS-related neutropenia and neutrophil dysfunction can (partly) be reversed by granulocyte-colony stimulating factor (G-CSF). We studied the effect of G-CSF on neutrophil increment and levels of soluble Fc gamma receptor type III in 15 patients with AIDS-related lymphoma (ARL) undergoing chemotherapy. In six of these
Malignant histiocytosis-like B-cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature.: Br J Haematol. 1997 Dec;99(3):656-64. Unique Identifier : AIDSLINE MED/98062252; Murase T; Nakamura S; Tashiro K; Suchi T; Hiraga J; Hayasaki N; Kimura M; Murakami M; Mizoguchi Y; Suzuki T; Saito H; Department of Haematology, Toyota Memorial Hospital, Japan.; Malignant histiocytosis (MH)-like B-cell lymphoma (BCL) is a neoplastic proliferation of large B cells clinically characterized by fever, hepatosplenomegaly, haemophagocytosis and abnormal laboratory data, without lymphadenopathy or skin lesions. Interestingly, most cases have been reported in Asian patients, and it i
Tropism of human herpesvirus 8 for peripheral blood lymphocytes in patients with Castleman's disease.: Br J Haematol. 1997 Dec;99(4):790-3. Unique Identifier : AIDSLINE MED/98092320; Kikuta H; Itakura O; Taneichi K; Kohno M; Department of Paediatrics, Hokkaido University School of Medicine,; Sapporo, Japan.; Multicentric Castleman s disease (MCD), also called multicentric angiofollicular lymphoid hyperplasia, is a systemic lymphoproliferative disorder causing fever, lymphadenopathy and splenomegaly. Recently, Kaposi s sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) DNA sequences have been detected in cases
Intraclonal molecular heterogeneity suggests a hierarchy of pathogenetic events in Burkitt's lymphoma.: Ann Oncol. 1997 Oct;8(10):987-94. Unique Identifier : AIDSLINE MED/98063764; Gutierrez MI; Bhatia K; Cherney B; Capello D; Gaidano G; Magrath I; Pediatric Branch, National Cancer Institute, NIH, Bethesda, MD; 20892-1928, USA.; BACKGROUND: Burkitt s lymphoma is a B-cell neoplasm characterized by a chromosomal translocation involving the c-myc gene. BL may carry, besides the c-myc translocation, several other lesions including a) mutations in c-myc, b) mutations in bcl-6, c) mutations in p53 and d) EBV genomes. In this report we describe a un
Antiviral activity of derivatized dextrans on HIV-1 infection of primary macrophages and blood lymphocytes.: Biochim Biophys Acta. 1997 Nov 28;1362(1):47-55. Unique Identifier : AIDSLINE MED/98094188; Seddiki N; Mbemba E; Letourneur D; Ylisastigui L; Benjouad A; Saffar L; Gluckman JC; Jozefonvicz J; Gattegno L; Laboratoire de Biologie Cellulaire, Universite Paris-Nord, Bobigny,; France.; The present study demonstrates at the molecular level that dextran derivatives carboxymethyl dextran benzylamine (CMDB) and carboxymethyl dextran benzylamine sulfonate (CMDBS), characterized by a statistical distribution of anionic carboxylic groups, hydrophobic benzylamide units, and/or sulfonate moieties, interact w
Synthesis and characterization of high-molecular mass polyethylene glycol-conjugated oligonucleotides.: Bioconjug Chem. 1997 Nov-Dec;8(6):793-7. Unique Identifier : AIDSLINE MED/98068462; Bonora GM; Ivanova E; Zarytova V; Burcovich B; Veronese FM; Pharmaco-Chemico-Technology Department, University of Cagliari, Italy.; bonora@chor02.chor.unipd.it; The use of synthetic oligonucleotides as possible drugs for human therapy is usually hampered by their low in vivo stability and capacity to achieve high concentrations at their cellular targets. To overcome this, it has been suggested that they be modified chemically. Among the various options, conjugation with short
Probing biomolecule recognition with electron transfer: electrochemical sensors for DNA hybridization.: Bioconjug Chem. 1997 Nov-Dec;8(6):906-13. Unique Identifier : AIDSLINE MED/98068476; Napier ME; Loomis CR; Sistare MF; Kim J; Eckhardt AE; Thorp HH; Department of Chemistry, University of North Carolina, Chapel Hill; 27599-3290, USA.; Identifying infectious organisms, quantitating gene expression, and sequencing genomic DNA on chips all rely on the detection of nucleic acid hybridization. Described here is a novel assay for detection of the hybridization of products of the polymerase chain reaction using electron transfer from guanine to a transiti
Prevalence of Dirofilaria immitis infection in cats in Saitama, Japan.: J Vet Med Sci. 1997 Oct;59(10):869-71. Unique Identifier : AIDSLINE MED/98028126; Nogami S; Sato T; Department of Veterinary Medicine, Nihon University, Kanagawa, Japan.; To clarify Dirofilaria immitis infection among cats in Saitama Prefecture, Japan , 1,840 cats were examined postmortem for adult worms and microfilariae in the blood from 1989 to 1995. As a reference control, 500 dogs from the same area were examined in the same way and period. D. im
Effects of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) in surface lymph nodes of rhesus monkeys (Macaca mulatta) chronically infected with simian immunodeficiency virus (SIVmac239).: J Vet Med Sci. 1997 Oct;59(10):891-6. Unique Identifier : AIDSLINE MED/98028130; Otani I; Fujii Y; Akari H; Mukai R; Mori K; Ono F; Kojima E; Machida M; Murakami K; Doi K; Yoshikawa Y; Tsukuba Primate Center, National Institute of Infectious Diseases,; Ibaraki, Japan.; We studied the effects of 6-chloro-2 ,3 -dideoxyguanosine 6-Cl-ddG), an antiretroviral drug, in surface lymph nodes of rhesus monkeys (Macaca mulatta) chronically infected with simian immunodeficiency virus (SIV). The rhesus monkeys were treated with 25 mg/kg of 6-Cl-ddG every 8 hr for 2 weeks. We performed sequential
[Infection as a metaphor for the fear of pollution]: Pflege. 1997 Feb;10(1):10-7. Unique Identifier : AIDSLINE MED/97274536; Kathan B; Innsbrucker Institut fur Alltagsforschung.; Not only nurses, but all kinds of professional helpers find it difficult to talk about their experiences with filth and dirtiness , both terms used in the figurative and in the literal scene. They feel such a subject questions both the ideal of their profession als well as their behaviour as professionals. However,
[Rifampicin toxicity in HIV-infected patients: A study of its incidence and the risk factors]: An Med Interna. 1997 Nov;14(11):559-64. Unique Identifier : AIDSLINE MED/98081269; Gort A; Falguera M; Schoenenberger JA; Servicio de Medicina Interna, Hospital Universitario Arnau de; Vilanova, Lerida.; OBJECTIVE: Evaluate the effect of HIV infection in the appearance of toxicity in patients treated with rifampin, analysing the involved elements in its genesis. METHODS: We realized a comparative study of the epidemiologic and clinical characteristics, and the incidence of adverse reactions to rifampin (between 1986-1
[Home care for the terminal HIV patient (letter)]: An Med Interna. 1997 Nov;14(11):595; discussion 596-7. Unique Identifier : AIDSLINE MED/98081280; Sanchez Ayuso FJ; Fernandez Rodriguez F; Fernandez Gonzalez E
[HIV infection at an advanced or terminal stage (letter)]: An Med Interna. 1997 Nov;14(11):595-6; discussion 596-7. Unique Identifier : AIDSLINE MED/98081281; Madrid F; Romero C; Barrio JL
HTLV-1-associated diseases.: Int J Hematol. 1997 Oct;66(3):257-78. Unique Identifier : AIDSLINE MED/98064539; Watanabe T; Department of Pathology, University of Tokyo, Japan.; tnabe@ims.u-tokyo.ac.jp; HTLV-1-infection is associated with a variety of human diseases including adult T-cell leukemia (ATL) and non-neoplastic inflammatory diseases. The latter includes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 uveitis (HU) and other diseases with unestablished associations such as arth
Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients.: Int J Hematol. 1997 Oct;66(3):345-51. Unique Identifier : AIDSLINE MED/98064547; Okamoto T; Okada M; Mori A; Saheki K; Takatsuka H; Wada H; Tamura A; Fujimori Y; Takemoto Y; Kanamaru A; Kakishita E; Second Department of Internal Medicine, Hyogo College of Medicine,; Japan.; Immunological abnormalities (IA) are frequently observed in patients with myelodysplastic syndromes (MDS). Although there have been a number of analyses of the prognostic factors, there have been few studies, if any, to determine whether IA affects prognosis. We investigated the prognosis of 153 MDS patients with or w
Kaposi's sarcoma--associated herpesvirus-like DNA sequences are not present in adult T-cell leukemia [letter]: Int J Hematol. 1997 Oct;66(3):391-2. Unique Identifier : AIDSLINE MED/98064554; Kohno T; Yamada Y; Tsushima H; Sata T; Matsuyama T; Tomonaga M; Kamihira S
Nutritional and immunologic evaluation of patients with gastric cancer before and after surgery.: Nutrition. 1997 Oct;13(10):878-81. Unique Identifier : AIDSLINE MED/98019872; Rey-Ferro M; Castano R; Orozco O; Serna A; Moreno A; Gastrointestinal Surgery and Endoscopy Program, National Cancer; Institute, Santafe de Bogota, Colombia.; The main objective was to evaluate a patient s immunologic and nutritional status as a prognostic indicator of morbidity and mortality in patients with gastric cancer. A prospective clinical study carried out at the National Cancer Institute in Bogota,
Transactivation of the interleukin-1 alpha promoter by human T-cell leukemia virus.: Leuk Lymphoma. 1997 Aug;26(5-6):421-33. Unique Identifier : AIDSLINE MED/98049219; Mori N; Prager D; Department of Medicine, Cedars-Sinai Medical Center, UCLA School of; Medicine, Los Angeles, USA.; The expression of interleukin-1 alpha (IL-1 alpha) appears to be tightly regulated, as the levels of constitutive expression in normal cells is extremely low. In contrast to normal hematopoietic cells, human T-cell leukemia virus type I HTLV-I)-infected T-cell lines constitutively produce high levels of IL-1 alpha mRN
Acute promyelocytic leukemia in a HIV seropositive patient.: Leuk Lymphoma. 1997 Aug;26(5-6):621-4. Unique Identifier : AIDSLINE MED/98049238; Calvo R; Ribera JM; Battle M; Sancho JM; Granada I; Flores A; Milla F; Feliu E; Hematology Department, Hospital Universitari Germans Trias i Pujol,; Universitat Autonoma of Barcelona, Spain.; Acute myeloid leukemia (AML) is infrequent in patients with human immunodeficiency virus (HIV) infection. Among AML, acute promyelocytic leukemia (APL) has been rarely described in such patients, with only one case being published. We report a 30 years-old intravenous drug abuser HIV-infected male with APL who attaine
Clonal populations of T-cells in patients with B-cell malignancies.: Leuk Lymphoma. 1997 Oct;27(3-4):231-8. Unique Identifier : AIDSLINE MED/98063914; Moss PA; Gillespie G; Department of Haematology and Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford, U.K.; Patients with B-cell malignancies are often immunosuppressed and have defective T-cell function in vitro. In addition they frequently have unusual T-cell populations in the peripheral blood including an increase in the number of activated T-cells and an inverted CD4:CD8 ratio. More recently several reports have docume
Benign and malignant smooth muscle tumors containing Epstein-Barr virus in children with AIDS.: Leuk Lymphoma. 1997 Oct;27(3-4):303-14. Unique Identifier : AIDSLINE MED/98063919; Jenson HB; Leach CT; McClain KL; Joshi VV; Pollock BH; Parmley RT; Chadwick EG; Murphy SB; Department of Pediatrics, University of Texas Health Science Center at; San Antonio, USA. jenson@uthscsa.edu; Smooth muscle tumors (leiomyosarcomas) are the second most prevalent malignancy of children with the acquired immunodeficiency syndrome (AIDS). We have investigated the tumors, plasma, and peripheral white blood cells of eight children with AIDS with smooth muscle tumors for evidence of tumor association with human im
Eosinophilia associated with clonal T-cell proliferation.: Leuk Lymphoma. 1997 Oct;27(3-4):335-42. Unique Identifier : AIDSLINE MED/98063923; Kitano K; Ichikawa N; Shimodaira S; Ito T; Ishida F; Kiyosawa K; The Second Department of Internal Medicine, Shinshu University School; of Medicine, Matsumoto, Nagano-ken, Japan.; Eosinophilia associated with the expansion of cloned T-cells is reviewed in relation to cytokine production. It has been proved that eosinophilopoiesis is caused by eosinophil-stimulating cytokines, including interleukin-5 (IL-5), granulocyte-macrophage colony-stimulating factor and interleukin-3, which are secreted f
Low-dose donor CD8+ cells in the CD4-depleted graft prevent allogeneic marrow graft rejection and severe graft-versus-host disease for chronic myeloid leukemia patients in first chronic phase.: Bone Marrow Transplant. 1997 Dec;20(11):945-52. Unique Identifier : AIDSLINE MED/98082936; Gallardo D; Garcia-Lopez J; Sureda A; Canals C; Ferra C; Cancelas JA; Berlanga JJ; Brunet S; Boque C; Picon M; Torrico C; Amill B; Martino R; Martinez C; Martin-Henao G; Domingo-Albos A; Granena A; Department of Clinical Hematology, Hospital Duran i Reynals, Institut; Catala d'Oncologia, Barcelona, Spain.; Based on previous experiences in animals and humans, low doses of CD8+ lymphocytes infused together with the marrow graft seem to enhance engraftment after allogeneic T cell-depleted marrow transplantation. From April 1994 to February 1997, 12 patients with chronic myelogenous leukemia in first chronic phase receiving
Prevalence and clinical features of hepatitis G virus infection in bone marrow allograft recipients.: Bone Marrow Transplant. 1997 Dec;20(11):965-8. Unique Identifier : AIDSLINE MED/98082939; Corbi C; Traineau R; Esperou H; Ravera N; Portelette E; Benbunan M; Gluckman E; Loiseau P; ETS AP-HP Site Hopital Saint-Louis, Paris, France.; To study the prevalence and clinical features of hepatitis G virus (HGV)/GB virus C (GBV-C) infection in bone marrow transplantation (BMT), we examined frozen serum samples from 95 bone marrow allograft patients for HGV/GBV-C RNA by RT-PCR. Twenty-eight out of 95 (29.5%) were positive and 14 of the HGV+ patients were
Lack of NK cells in lupus patients with renal involvement.: Lupus. 1997;6(9):708-12. Unique Identifier : AIDSLINE MED/98074465; Erkeller-Yuksel FM; Lydyard PM; Isenberg DA; Department of Immunology, University College, London, UK.; fezay@pipex.dial.com; We have previously shown that patients with SLE have significantly lower percentages and absolute numbers of NK(CD3-/CD16+56) cells in their peripheral blood compared with normals. Patients with active disease had very low levels of NK cells and the reduction was also associated with patients who had renal involvement
World AIDS day--children and HIV.: Commun Dis Rep CDR Wkly. 1997 Nov 28;7(48):425, 428. Unique Identifier : AIDSLINE MED/98086917
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1997 Nov 28;7(48):433-4. Unique Identifier : AIDSLINE MED/98086918
[Pediatric resuscitator or the "Elisee" complex (letter)]: Arch Pediatr. 1997 Oct;4(10):1017-9. Unique Identifier : AIDSLINE MED/98099089; Gosme-Seguret S; Mokhtari M; Le Bouedec S; Huon C
Epstein-Barr virus-related Hodgkin's disease showing B cell lineage in an immunosuppressive patient seropositive for HTLV-I.: Pathol Int. 1997 Nov;47(11):801-5. Unique Identifier : AIDSLINE MED/98074522; Murata T; Nakamura S; Kato H; Yatabe Y; Shiraishi T; Kuroda M; Yatani R; Suchi T; Department of Pathology and Clinical Laboratories, JA Suzuka Hospital,; Japan.; A case of Hodgkin s disease (HD), lymphocyte depression (LD) type in an immunosuppressive patient is described. The patient was a 48-year-old male and his parents were born in the Kyushu area, which is an endemic area for adult T cell lymphoma/leukemia ATL). He was seropositive for ATL virus (ATLV, also referred to as
[Accepting life styles--an important aspect in AIDS care]: Pflege Aktuell. 1997 Feb;51(2):110-1. Unique Identifier : AIDSLINE MED/97250192; Wagner K
HIV prophylaxis for health care workers.: J Occup Environ Med. 1997 Dec;39(12):1212-9. Unique Identifier : AIDSLINE MED/98090873; Forst LS; Fletcher B; Department of Emergency Medicine, School of Public Health, University; of Illinois at Chicago 60612, USA.; The US Public Health Service (PHS) published new recommendations for preventing HIV seroconversion in health care workers suffering needle-stick injuries. In response, health care institutions across the United States are updating their internal protocols to meet the currently accepted
Expression of human immunodeficiency virus genes using baculovirus expression system.: Mol Biotechnol. 1997 Oct;8(2):173-87. Unique Identifier : AIDSLINE MED/98069262; Kang CY; Faculty of Science, Western Science Centre, University of Western; Ontario, London, Canada. scicyk@uwoadmin.uwo.ca; The structural protein genes of HIV-1 and HIV-2 have been expressed in Spodoptera frugiperda (SF) cells using baculovirus expression system. The noncoding flanking sequences of HIV structural genes were removed and a putative ribosome binding site was placed in front of the open reading frame of each gene by using cro
Long-awaited Canadian blood report released [news]: Nat Med. 1998 Jan;4(1):10. Unique Identifier : AIDSLINE MED/98087463; Murray T
Ethical considerations of clinical trials to prevent vertical transmission of HIV in developing countries.: Nat Med. 1998 Jan;4(1):11-2. Unique Identifier : AIDSLINE MED/98087465; Zion D; School of International Health, University of Tokyo and Centre for; Human Bioethics, Monash University. dzion@m.u-tokyo.ac.jp
Giving HIV a dose of its own medicine [news]: Nat Med. 1998 Jan;4(1):17. Unique Identifier : AIDSLINE MED/98087469; Bonetta L
HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo.: Nat Med. 1998 Jan;4(1):65-71. Unique Identifier : AIDSLINE MED/98087480; Goh WC; Rogel ME; Kinsey CM; Michael SF; Fultz PN; Nowak MA; Hahn BH; Emerman M; Division of Molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98109, USA.; The human immunodeficiency virus type 1 (HIV-1) encodes a protein, called Vpr, that prevents proliferation of infected cells by arresting them in G2 of the cell cycle. This Vpr-mediated cell-cycle arrest is also conserved among highly divergent simian immunodeficiency viruses, suggesting an important role in the virus
India to develop its own AIDS vaccine [news]: Nat Med. 1998 Jan;4(1):7. Unique Identifier : AIDSLINE MED/98087457; Jayaraman KS
Sabin Institute joins Georgetown University [news]: Nat Med. 1998 Jan;4(1):7. Unique Identifier : AIDSLINE MED/98087458; Watanabe ME
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.: Nat Med. 1998 Jan;4(1):72-7. Unique Identifier : AIDSLINE MED/98087481; Donzella GA; Schols D; Lin SW; Este JA; Nagashima KA; Maddon PJ; Allaway GP; Sakmar TP; Henson G; De Clercq E; Moore JP; The Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; The bicyclam AMD3100 (formula weight 830) blocks HIV-1 entry and membrane fusion via the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal antibody 12G5 from binding to CXCR4, but has no effect on binding of monoclonal antibody 2D7 to CCR5. It also inhibits binding of the CXC-chemokine, SDF-1alpha, to C
US boosts disease surveillance effort [news]: Nat Med. 1998 Jan;4(1):9. Unique Identifier : AIDSLINE MED/98087462; Dickey C
The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor [see comments]: Nat Med. 1998 Jan;4(1):92-6. Unique Identifier : AIDSLINE MED/98087485; Calleja C; Pascussi JM; Mani JC; Maurel P; Vilarem MJ; INSERM Unite 128, IFR 24, CNRS BP 5051, Montpellier, France.; The glucocorticoid receptor (GR) belongs to a superfamily of ligand-regulated nuclear steroid hormone receptors. The steps in the signal transduction pathway leading to the biological effects of glucocorticoids (GCs) include sequentially binding of the steroid to the GR ligand binding domain (LBD), receptor transforma
[Evaluation of the prevalence of HIV infection in prison inmates at the time of their imprisonment during the period 1991-1995]: Rev Esp Salud Publica. 1997 May-Jun;71(3):269-80. Unique Identifier : AIDSLINE MED/98083262; Martin Sanchez V; Cayla Buqueras JA; Gonzalez Moris ML; Herrero Alonso LE; Vicente Perez R; Servicio Medico. Centro Penitenciario, Leon.; BACKGROUND: Inmates of Spanish prisons include a high number of intravenous drug users (IVDUs) and other people whose practices entail the risk of infection with the human immunodeficiency virus (HIV). The aim of this work is to find out the evolution of the prevalence of HIV infection at the time of admission to pris
[Specific mortality rates at the Algeciras hospital during 1995-1996]: Rev Esp Salud Publica. 1997 May-Jun;71(3):305-15. Unique Identifier : AIDSLINE MED/98083265; Garcia Ortega C; Almenara Barrios J; Garcia Ortega JJ; Area de Medicina Preventiva y Salud Publica, Universidad de Cadiz.; BACKGROUND: In-hospital mortality has been proposed as an indicator of health care quality. It is also a fact that should be used for epidemiological monitoring and health planning. The aim of this work is to analyse the mortality in Algeciras Hospital, belonging to the Andalusia Health Authority. METHODS: A descripti
Universal use of low-osmolar contrast media: a European perspective.: Acad Radiol. 1994 Nov;1(3):295-7. Unique Identifier : AIDSLINE MED/98080772; Thomsen HS; Department of Diagnostic Radiology, Herlev Hospital, University of; Copenhagen, Denmark.
HIV replication [news]: Mol Med Today. 1995 Apr;1(1):2. Unique Identifier : AIDSLINE MED/98076836; Kingman S
New vaccine strategies.: Mol Med Today. 1995 Jun;1(3):108-9. Unique Identifier : AIDSLINE MED/98076851; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.
Application of antisense technology to therapeutics.: Mol Med Today. 1995 Jun;1(3):128-33. Unique Identifier : AIDSLINE MED/98076856; Heidenreich O; Kang SH; Xu X; Nerenberg M; Department of Neuropharmacology, Scripps Research Institute, La Jolla,; CA 92037, USA.; Antisense oligonucleotides inhibit gene expression by binding in a sequence-specific manner to an RNA target. Modern nucleotide chemistry has enabled the synthesis of chemically modified oligonucleotides that are highly resistant to nuclease degradation. Among other applications, these agents are currently being evalu
Baboons, stem cells, facilitator cells and AIDS [news]: Mol Med Today. 1995 Nov;1(8):349. Unique Identifier : AIDSLINE MED/98076884; Fricker J
Pathology of pediatric AIDS.: Pathology (Phila). 1993;2(1):81-101. Unique Identifier : AIDSLINE MED/98082502; Anderson VM; Zevallos E; State University of New York, Health Science Center at Brooklyn 11203,; USA.; AIDS in children most often results from the transmission of HIV from an infected mother to her newborn infant. The number of HIV-infected infants and children is increasing. This chapter addresses the natural history of the disease, opportunistic and other infections in afflicted patients, lymphoproliferative syndrom
Increased potency of Fc-receptor-targeted antigens.: Cancer Immunol Immunother. 1997 Nov-Dec;45(3-4):146-8. Unique Identifier : AIDSLINE MED/98098148; Guyre PM; Graziano RF; Goldstein J; Wallace PK; Morganelli PM; Wardwell K; Howell AL; Department of Physiology, Dartmouth-Hitchcock Medical Center, Lebanon,; NH 03756, USA. paul.guyre@dartmouth.edu; A major challenge for using native and modified T cell epitopes to induce or suppress immunity relates to achieving efficient uptake and processing by antigen-presenting cells (APC) in vivo. IgG Fc receptors, which are expressed constitutively by professional APC including monocytes and dendritic cells, have long been
Bispecific antibody treatment of murine B cell lymphoma.: Cancer Immunol Immunother. 1997 Nov-Dec;45(3-4):162-5. Unique Identifier : AIDSLINE MED/98098153; De Jonge J; Heirman C; De Veerman M; Van Meirvenne S; Demanet C; Brissinck J; Thielemens K; Laboratory of Physiology, Medical School, Vrije Universiteit Brussel,; (VUB), Belgium.; This report summarizes our experimental data concerning the use of bispecific antibodies (bsAb) for the treatment of the murine BCL1 B cell lymphoma model. Initially we used a hybrid-hybridoma-derived bsAb with specificity for the TcR/CD3 complex on T cells and the idiotype of the membrane-bound IgM on the tumor cells
Construction and biological activity of a recombinant bispecific single-chain antibody designed for therapy of minimal residual colorectal cancer.: Cancer Immunol Immunother. 1997 Nov-Dec;45(3-4):193-7. Unique Identifier : AIDSLINE MED/98098161; Kufer P; Mack M; Gruber R; Lutterbuse R; Zettl F; Riethmuller G; Institute of Immunology, University of Munich, Germany.; Unlike monoclonal antibodies, clinical application of bispecific antibodies has so far lagged behind because of difficult, low-yield production techniques as well as considerable toxicity attributed to bispecific antibody preparations containing immunoglobulin-Fc parts and anti-CD3 homodimers. These difficulties were
CD3 x CD19 bispecific antibodies and CD28 costimulation for locoregional treatment of low-malignancy non-Hodgkin's lymphoma.: Cancer Immunol Immunother. 1997 Nov-Dec;45(3-4):198-202. Unique Identifier : AIDSLINE MED/98098162; Manzke O; Titzer S; Tesch H; Diehl V; Bohlen H; University of Cologne, Clinic I for Internal Medicine, Germany.; In advance of using bispecific antibodies for the treatment of B cell lymphoma in humans, we analysed CD3 x CD19 bispecific antibodies for their capacity to induce T cell activation in cell suspensions from follicular lymphoma lymph nodes. Here, we demonstrate that the lack of costimulatory molecules, such as members
Decreased function of monocytes and granulocytes during HIV-1 infection correlates with CD4 cell counts.: Eur J Med Res. 1995 Oct 16;1(1):9-15. Unique Identifier : AIDSLINE MED/98055840; Dobmeyer TS; Raffel B; Dobmeyer JM; Findhammer S; Klein SA; Kabelitz D; Hoelzer D; Helm EB; Rossol R; Dept. of Medicine III, University Hospital, Theodor-Stern-Kai 7; Frankfurt D-60590, Germany.; Monocytes and neutrophils are involved in the primary immune response against opportunistic infections that occur during the progression of human immunodeficiency virus (HIV) infection towards development of acquired immune deficiency syndrome AIDS). Phagocytic cells operate through the generation of reactive oxygen s
Observational analysis of German injecting drug users (IDU): survival with and without methadone maintenance treatment. German AIDS Study Group GASG/IdkF.: Eur J Med Res. 1996 Jan 19;1(4):209-14. Unique Identifier : AIDSLINE MED/98107485; BACKGROUND: There are conflicting data on the effects of morphines on immunological functions in injecting drug users IDU). In order to address whether methadone maintenance therapy for IDU with HIV infection results in any clinically important effects we did an observational study prompted by the fact that prospectiv
Subtypes of HIV-1 and the impact of dual infections of HIV-1 and measles virus on micronutrient levels of pregnant women in Harare, Zimbabwe.: Cent Afr J Med. 1997 Jun;43(6):165-72. Unique Identifier : AIDSLINE MED/98093872; Obi CL; McAdoo HP; Onigbinde AO; Murray M; Tswana SA; Moyo SR; Department of Medical Microbiology, University of Zimbabwe Medical; School, Avondale, Harare, Zimbabwe.; OBJECTIVE: To determine subtypes of HIV-1, simultaneous prevalence of HIV-1 and measles virus antibodies and their impact on micronutrient levels of pregnant women in Harare, Zimbabwe . DESIGN: Cross sectional. SETTING: Budiriro and Edith Opperman Antenatal Clinics Harare; Departm
HIV infection and HIV-1 clades among pregnant women in Harare, Zimbabwe.: Cent Afr J Med. 1997 Jul;43(7):188-92. Unique Identifier : AIDSLINE MED/98093879; Obi CL; McAdoo HP; Murray M; Tswana SA; Moyo SR; Department of Medical Microbiology, University of Zimbabwe Medical; School, Avondale, Harare, Zimbabwe.; OBJECTIVE: To determine HIV-1 seropositivity and HIV-1 clades/subtypes among pregnant women attending different clinics in Harare, Zimbabwe . DESIGN: A prospective study. SUBJECTS: 206 pregnant women attending Edith Opperman and Budiriro clinics in Harare. MAIN OUTCOME MEASURES: F
Prevalence of gonorrhoea and knowledge of sexually transmitted infections in a farming community in Zimbabwe.: Cent Afr J Med. 1997 Jul;43(7):192-5. Unique Identifier : AIDSLINE MED/98093880; Gomo E; Ndamba J; Nhandara C; Murahwa SZ; Nyazema NZ; Blair Research Laboratory, Harare, Zimbabwe.; OBJECTIVE: To determine the prevalence of gonorrhoea and knowledge about sexually transmitted infections in a farming community. DESIGN: Cross sectional study. SETTING: Commercial farming area, Zimbabwe . SUBJECTS: 1,005 individuals aged between 15 and 60 years. MAIN OUTCOME MEASU
Bacillary angiomatosis in an HIV positive child. First case report in Zimbabwe.: Cent Afr J Med. 1997 Aug;43(8):238-9. Unique Identifier : AIDSLINE MED/98093892; Chitsike I; Muronda C; Department of Paediatrics and Child Health, University of Zimbabwe; Medical School, Avondale, Harare, Zimbabwe.; Bacillary angiomatosis is a recently recognised condition that is seen mainly in adult patients with the acquired immunodeficiency syndrome (AIDS). Its importance lies in the fact that it can be confused with Kaposi s sarcoma which is now the commonest malignant condition in male adult patients in this country. Unlike
[Kaposi sarcoma]: Cancer Radiother. 1997;1(4):277-82. Unique Identifier : AIDSLINE MED/98098106; Kirova YM; Belembaogo E; Frikha H; Yu SJ; Le Bourgeois JP; Departement de cancerologie, Hopital Henri-Mondor, Creteil, France.; Moriz Kaposi was the first who, in 1872, described five patients presenting with sarcoma idiopathicum multiple hemorrhagicum . In 1912 Sternberg termed this disease Kaposi s sarcoma. Since then various forms of this rare disease have been observed. In 1914 Hallenberg described the first cases of African or endemic Ka
T cell populations and cytokine expression in milk derived from normal and bacteria-infected bovine mammary glands.: Cell Immunol. 1997 Nov 25;182(1):68-76. Unique Identifier : AIDSLINE MED/98089248; Taylor BC; Keefe RG; Dellinger JD; Nakamura Y; Cullor JS; Stott JL; Department of Pathology, Microbiology, and Immunology, School of; Veterinary Medicine, University of California, Davis 95616, USA.; bctaylor@mail.uwlax.edu; This study investigated the effect of naturally acquired bacterial infection of the bovine mammary gland on subpopulations of T lymphocytes and cytokine expression in milk. Twenty-nine lactating cows with mastitis were compared to 12 normal animals. CD4+ lymphocytes represented a significantly greater percentage of th
Dental care associated with an outbreak of HIV infection among dialysis patients.: Rev Panam Salud Publica. 1997 Sep;2(3):194-202. Unique Identifier : AIDSLINE MED/98051994; Bautista LE; Orostegui M; Industrial University of Santander, School of Medicine, Bucaramanga,; Colombia.; An outbreak of 14 cases of human immunodeficiency virus (HIV) infection was discovered by chance in May 1993 among hemodialysis patients at a university hospital in Bucaramanga, Colombia . The outbreak occurred in 1992. Stored sera w
[Prevention and control of tuberculosis and AIDS (editorial)]: Chung Hua Chieh Ho Ho Hu Hsi Tsa Chih. 1996 Jun;19(3):131-2. Unique Identifier : AIDSLINE MED/98048725; Yan B
[Clinicopathological study of 34 autopsy cases of mycobacteriosis in patients with acquired immunodeficiency syndrome]: Chung Hua Chieh Ho Ho Hu Hsi Tsa Chih. 1996 Jun;19(3):136-9. Unique Identifier : AIDSLINE MED/98048726; Liu D; Lin CS; Department of Pathology, Bengbu Medical College, Anhui Province.; OBJECTIVE: Clinicopathological features of mycobacteriosis were studied by means of microscopical examination of 34 autopsy cases in patients with acquired immunodeficiency syndrome (AIDS) and the diagnostic methods were evaluated. METHODS: All cases were anatomized, sampled, fixed and embedded routinely and stained we
[Expression of retroviral transmembrane envelope protein p15E in human malignant cells]: Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 1996 Dec;18(6):416-22. Unique Identifier : AIDSLINE MED/98050329; Luo L; Yuan W; Tian J; Zhang Y; Cancer Institute, CAMS, Beijing.; Malignant tumor growth is always accompanied with immune suppression. Tumor-derived immuno-suppressive factors, among others, are thought to be responsible, but their nature is not well defined. The paper reports on the expression of an immuno-suppressive retroviral transmembrane envelope protein p15E at different leve
Increased drug reactions in HIV-1-positive patients: a possible explanation based on patterns of immune dysregulation seen in HIV-1 disease. The Military Medical Consortium for the Advancement of Retroviral Research (MMCARR).: Clin Exp Dermatol. 1997 May;22(3):118-23. Unique Identifier : AIDSLINE MED/98086882; Smith KJ; Skelton HG; Yeager J; Ledsky R; Ng TH; Wagner KF; United States Army Medical Research Institute for Chemical Defense,; Aberdeen, Maryland, USA.; Drug reactions are common in HIV-1 disease, with the incidence having been reported to increase with increasing stage and with CD4+ T-cell counts below 200/microliters. However, there have been numerous reports of patients in which rechallenge, dosing changes or continued therapy have resulted in no recurrence or elsee
Adhesion molecules in HIV-related and idiopathic polymyositis: immunohistochemical studies.: Clin Neuropathol. 1997 Nov-Dec;16(6):312-8. Unique Identifier : AIDSLINE MED/98065330; Carota A; Pizzolato GP; Redard M; Gailloud P; Grau GE; Department of Pathology, Neuropathology Unit, Geneva University; Hospital, Switzerland.; Idiopathic polymyositis (IPM) and HIV polymyositis (HIV-PM) are considered to be related autoimmune diseases whose target is skeletal muscle. They have been associated to a T cell-mediated and MHC-I-restricted cytotoxic phenomenon, but both etiology and physiopathology remain incompletely understood. Their histologicae
In vitro and in vivo effects of the arylamine human immunodeficiency virus protease inhibitor 4R-(4alpha,5alpha,6beta, 7beta)-1-[(3-(1-imidazoylcarbamoyl)phenyl)methyl]-3-[(3-aminophen- yl)m ethyl]hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-2H-1, 3-diazepin-2-one (SD894) on rat hepatic cytochrome P450 2B and 3A.: Drug Metab Dispos. 1997 Dec;25(12):1424-8. Unique Identifier : AIDSLINE MED/98057445; Grubb MF; Diamond S; Christ DD; Drug Metabolism and Pharmacokinetics Section, The DuPont Merck; Pharmaceutical Company, Newark, DE 19714, USA.; The human immunodeficiency virus-1 protease inhibitor SD894 was evaluated as an inhibitor and inducer of cytochromes P450 (CYPs) in rats. After addition of 10 &mgr;M SD894 and 2 mM NADPH to liver microsomes from dexamethasone-treated rats, a type II spectrum appeared. Within 2 min, it was replaced by a type III spe
Evaluation of gastrointestinal absorption and metabolism.: Drug Metab Rev. 1997 Nov;29(4):957-75. Unique Identifier : AIDSLINE MED/98083459; Zimmerman CL; Wen Y; Soria I; Pithavala YK; University of Minnesota College of Pharmacy, Minneapolis 55455, USA.; zimme005@maroon.tc.umn.edu
[HIV therapy with protease inhibitors: danger of cross resistance]: Dtsch Med Wochenschr. 1997 Dec 12;122(50):A31. Unique Identifier : AIDSLINE MED/98102596
Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation.: EMBO J. 1997 Dec 1;16(23):6964-76. Unique Identifier : AIDSLINE MED/98046027; Greenberg ME; Bronson S; Lock M; Neumann M; Pavlakis GN; Skowronski J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.; The nef gene of human and simian immunodeficiency viruses is critical for AIDS pathogenesis. Its function in vivo is unknown, but in vitro natural isolates of Nef down-regulate expression of the cell surface CD4 molecule, a component of the T cell antigen receptor and the viral receptor, by accelerating its endocytosi
Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.: EMBO J. 1997 Dec 1;16(23):6996-7007. Unique Identifier : AIDSLINE MED/98046030; Crump MP; Gong JH; Loetscher P; Rajarathnam K; Amara A; Arenzana-Seisdedos F; Virelizier JL; Baggiolini M; Sykes BD; Clark-Lewis I; Protein Engineering Network of Centers of Excellence (PENCE) and; Department of Biochemistry, 713 Heritage Medical Research Center,; University of Alberta, Edmonton, Alberta, Canada T6G 2S2.; The three-dimensional structure of stromal cell-derived factor-1 SDF-1) was determined by NMR spectroscopy. SDF-1 is a monomer with a disordered N-terminal region (residues 1-8), and differs from other chemokines in the packing of the hydrophobic core and surface charge distribution. Results with analogs showed that t
Lung and chest wall mechanics in patients with acquired immunodeficiency syndrome and severe Pneumocystis carinii pneumonia.: Eur Respir J. 1997 Oct;10(10):2343-50. Unique Identifier : AIDSLINE MED/98047156; D'Angelo E; Calderini E; Robatto FM; Puccio P; Milic-Emili J; Istituto di Fisiologia Umana I, Universita di Milano, Milan, Italy.; The aim of this study was to assess the mechanical characteristics of the respiratory system in patients with acquired immune deficiency syndrome (AIDS) and acute respiratory distress syndrome (ARDS) caused by Pneumocystis carinii pneumonia PCP). In 12 mechanically ventilated patients, total respiratory system mechani
Cytomegalovirus retinitis in the presence of a normal helper T-cell count [letter]: Eye. 1997;11 ( Pt 4):568-9. Unique Identifier : AIDSLINE MED/98086565; Morrison DA; Bibby K; Wiselka M; Rosenthal AR
Local therapy of CMV retinitis: a new therapeutical approach.: Dev Ophthalmol. 1997;29:64-8. Unique Identifier : AIDSLINE MED/98075617; Fuchs AV; Scheider A; Klauss V; Kampik A; Eye Hospital of the Ludwig-Maximilians-University, Munich, Germany.
Prevention--a complicated story [editorial; comment]: Dev Med Child Neurol. 1997 Dec;39(12):789. Unique Identifier : AIDSLINE MED/98093940; Bax M
[Azidothymidine, blocking telomerase functioning, shortens telomeric repeats in transformed human cells]: Genetika. 1997 Oct;33(10):1444-6. Unique Identifier : AIDSLINE MED/98065376; Egorov EE; Akhmalisheva AKh; Smirnova IuB; Shinkarev DB; Chernov DN; Zelenin AV; Kraevskii AA; The long-term action of azidothymidine, reverse transcriptase inhibitor, on cultivated U-937 (human promyelocyte leukemia) and MeWo (human melanoma) cells led to the concentration-dependent decrease in the length of telomeric chromosomal repeats. Telomere shortening was accompanied by temporary retardation of cell pro
[Effects of the nef and tat genes of the human immunodeficiency virus type I on rodent cells in vivo and in vitro]: Genetika. 1997 Sep;33(9):1202-8. Unique Identifier : AIDSLINE MED/98010859; Shugurova IM; Andreeva LE; Dubovaia VI; Zueva LA; Serova IA; Tarantul VZ; The tat and nef regulatory genes of the human immunodeficiency virus type I (HIV-1) under the control of eukaryotic promoters were transferred in vivo into mice and in vitro into rat cell cultures. The development was disturbed and adenocarcinomas of the lacrimal glands and pancreas appeared in transgenic mice carryin
Induction of selective anergy by toxic shock syndrome toxin-1 in CD8+ T cells.: Immunology. 1997 Oct;92(2):188-93. Unique Identifier : AIDSLINE MED/98076726; Zhao YX; Holmdahl R; Tarkowski A; Department of Rheumatology and Clinical Immunology, University of; Goteborg, Sweden.; Interferon-gamma (IFN-gamma) mRNA expression of murine splenic CD8+ T cells in response to toxic shock syndrome toxin-1 (TSST-1) was examined in vitro. In primary response to TSST-1, purified CD8+ cells expressed a low frequency of IFN-gamma mRNA and produced very little interleukin-2 (
Both CD4+ and CD8+ human lymphocytes are activated and proliferate in response to Cryptococcus neoformans.: Immunology. 1997 Oct;92(2):194-200. Unique Identifier : AIDSLINE MED/98076727; Syme RM; Wood CJ; Wong H; Mody CH; Department of Microbiology and Infectious Diseases, University of; Calgary, Alberta, Canada.; The current studies were performed to determine the contribution of T-cell subsets to lymphocyte proliferation in response to Cryptococcus neoformans, the most common invasive mycosis in acquired immune deficiency syndrome. We demonstrate for the first time that both human CD4 and CD8 cells are activated in response t
Detection of a novel 40,000 MW excretory Toxoplasma gondii antigen by murine Th1 clone which induces toxoplasmacidal activity when exposed to infected macrophages.: Immunology. 1997 Oct;92(2):284-9. Unique Identifier : AIDSLINE MED/98076739; Reichmann G; Stachelhaus S; Meisel R; Mevelec MN; Dubremetz JF; Dlugonska H; Fischer HG; Institute for Medical Microbiology and Virology,; Heinrich-Heine-University, Dusseldorf, Germany.; To analyse target molecules of the CD4+ T-cell response to toxoplasma infection, a panel of Toxoplasma gondii-specific murine CD4+ T-cell clones has been established. Clone 3Tx15, belonging to the T helper 1 (Th1) subtype, abolished intracellular parasite growth when co-cultured with macrophages and live toxoplasma at
The immunosuppressive peptide of HIV-1 gp41 like human type I interferons up-regulates MHC class I expression on H9 and U937 cells.: Immunol Lett. 1997 Nov;59(2):93-7. Unique Identifier : AIDSLINE MED/98039054; Chen YH; Xiao Y; Wu W; Zhao Y; Speth C; Dierich MP; Department of Biological Science and Biotechnology, Tsinghua; University, Beijing, China.; Based on our findings that the immunosuppressive peptide (ISP, amino acids (aa) 583-599) of human immunodeficiency virus type 1 HIV-1) gp41 shows sequence-similarity with human type I interferons (IFN-alpha and IFN-beta) and HIV-1 soluble gp41 sgp41, aa 539-684) enhanced cell surface expression of major histocompatibi
Molecular analysis of skewed Tcra-V gene use in T-cell receptor beta-chain transgenic mice.: Immunogenetics. 1998;47(2):107-14. Unique Identifier : AIDSLINE MED/98060822; Burns RP Jr; Natarajan K; LoCascio NJ; O'Brien DP; Kobori JA; Shastri N; Barth RK; University of Rochester Cancer Center and the Department of; Microbiology and Immunology, 601 Elmwood Avenue, Rochester, NY 14642,; USA.; The influence of beta-chain diversity on the expressed T-cell receptor (TCR) alpha-chain repertoire was investigated using transgenic mice which exclusively express a single rearranged TCR beta-chain gene. Analysis of these mice using alpha-chain-specific recombinant cDNA libraries showed that expression of the transg
MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes.: Immunogenetics. 1998;47(2):139-48. Unique Identifier : AIDSLINE MED/98060826; Zwirner NW; Fernandez-Vina MA; Stastny P; University of Texas Southwestern Medical Center, Department of; Internal Medicine, 5323 Harry Hines Blvd., Dallas, TX 75235-8886, USA.; MICA is a new polymorphic gene in the HLA region expressed in epithelial cell lines and gastrointestinal epithelium. Little is yet known about the MICA protein, and the pattern of its expression by freshly isolated cells has not been established. In the present experiments, we used antibodies raised in rabbits against
Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis.: Infect Immun. 1998 Jan;66(1):176-80. Unique Identifier : AIDSLINE MED/98084471; Torres M; Herrera T; Villareal H; Rich EA; Sada E; Department of Microbiology, National Institute of Respiratory; Diseases, Mexico D.F., Mexico.; Patients with active tuberculosis (TB) have a stronger humoral but a poorer cellular immune response to the secreted 30-kDa antigen (Ag) of Mycobacterium tuberculosis than do healthy household contacts (HHC), who presumably are more protected against disease. The basis for this observation was studied by examining the
Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani.: Infect Immun. 1998 Jan;66(1):18-27. Unique Identifier : AIDSLINE MED/98084450; Melby PC; Yang YZ; Cheng J; Zhao W; The Audie L. Murphy Veterans Administration Hospital, and Department; of Medicine, The University of Texas Health Science Center, San; Antonio 78284-7881, USA. melby@uthscsa.edu; Infection with the protozoan Leishmania donovani can cause serious visceral disease or subclinical infection in humans. To better understand the pathogenesis of this dichotomy, we have investigated the host cellular immune response to cutaneous or visceral infection in a murine model. Mice infected in the skin develop
Modulation of murine Lyme borreliosis by interruption of the B7/CD28 T-cell costimulatory pathway.: Infect Immun. 1998 Jan;66(1):266-71. Unique Identifier : AIDSLINE MED/98084483; Shanafelt MC; Kang I; Barthold SW; Bockenstedt LK; Department of Internal Medicine, Yale University School of Medicine,; New Haven, Connecticut 06520, USA. Linda.Bockenstedt@Yale.edu; Recent studies have implicated cytokines associated with Th2 cells in the genetic resistance to murine Lyme borreliosis. Because the B7/CD28 costimulatory pathway has been shown to influence the differentiation of Th-cell subsets, we investigated the contribution of the B7 molecules CD80 and CD86 to the Th2 cytokine p
Characterization of the immunostimulatory properties of Leishmania infantum HSP70 by fusion to the Escherichia coli maltose-binding protein in normal and nu/nu BALB/c mice.: Infect Immun. 1998 Jan;66(1):347-52. Unique Identifier : AIDSLINE MED/98084494; Rico AI; Del Real G; Soto M; Quijada L; Martinez-A C; Alonso C; Requena JM; Centro de Biologia Molecular Severo Ochoa, Consejo Superior de; Investigaciones Cientificas-Universidad Autonoma de Madrid,; Cantoblanco, Spain.; Leishmania infantum HSP70 has been described as an immunodominant antigen in both humans and dogs suffering from visceral leishmaniasis. In this study, we used L. infantum HSP70 fused to Escherichia coli maltose-binding protein (MBP), as the reporter protein, to analyze the influence of HSP70 on the immunogenicity of
Increased in vitro induced CD4+ and CD8+ T cell IFN-gamma and CD4+ T cell IL-10 production in stable relapsing multiple sclerosis.: Int J Neurosci. 1997 Aug;90(3-4):187-202. Unique Identifier : AIDSLINE MED/98013704; Brod SA; Nelson LD; Khan M; Wolinsky JS; Department of Neurology, University of Texas-Houston 77225, USA.; Multiple sclerosis (MS) is presumed to be a T-cell mediated chronic inflammatory disease of the central nervous system. Investigators previously demonstrated increased IFN-gamma pro-inflammatory) and IL-10 (counterregulatory anti-inflammatory) in MS. The balance of pro-inflammatory and counterregulatory anti-inflammat
Dissection of C1q capability of interacting with IgG. Time-dependent formation of a tight and only partly reversible association.: J Biol Chem. 1997 Dec 26;272(52):33234-44. Unique Identifier : AIDSLINE MED/98070530; Kaul M; Loos M; Institute of Medical Microbiology and Hygiene, Johannes Gutenberg; University, Hochhaus am Augustusplatz, 55101 Mainz, Germany.; C1q-bearing immune complexes have been observed in diseases such as rheumatoid arthritis and human immunodeficiency virus infection-associated neuropathy. For the purpose of understanding better the phenomenon of C1q-bearing immune complexes, we investigated the constancy of the C1q-IgG interaction. An enzyme-linked i
Nuclear export signal of IkappaBalpha interferes with the Rev-dependent posttranscriptional regulation of human immunodeficiency virus type I.: J Cell Sci. 1997 Nov;110 ( Pt 22):2883-93. Unique Identifier : AIDSLINE MED/98087168; Bachelerie F; Rodriguez MS; Dargemont C; Rousset D; Thomas D; Virelizier JL; Arenzana-Seisdedos F; Unite d'Immunologie Virale, Institut Pasteur, Paris, France.; De novo synthesized IkappaBalpha accumulates transiently in the nucleus where it inhibits NF-kappaB-dependent transcription and reduces nuclear NF-kappaB content. A sequence present in the C-terminal domain of IkappaBalpha and homologous to the HIV-1 Rev nuclear export signal (NES) has been recently defined as a funct
Characterization of one monoclonal antibody against feline immunodeficiency virus p24 and its application to antigen capture ELISA.: J Virol Methods. 1997 Nov;68(2):183-92. Unique Identifier : AIDSLINE MED/98049276; Kashiwase H; Ishimura M; Ishikawa Y; Nishigaki T; Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.; hiroto@shina.sankyo.co.jp; Several monoclonal antibodies (mAbs) were produced against feline immunodeficiency virus (FIV) p24 capsid antigen. One of these, F2710, reacted strongly, not only with viral p24 and recombinant p24, but also with p50 Gag precursor protein in Western blot. Epitope mapping analysis revealed that mAb F2710 recognizes a h
A method for the detection and confirmation of antibodies to hepatitis C virus in dried blood spots.: J Virol Methods. 1997 Nov;68(2):199-205. Unique Identifier : AIDSLINE MED/98049278; Parker SP; Cubitt WD; Ades AE; Department of Virology, Camelia Botnar Laboratories, Hospital for; Children, London, UK.; This study describes the development and evaluation of a cost effective test rationale for the detection of anti-HCV in dried blood spots. Samples were screened using an in house IgG ELISA that incorporated the recombinant proteins c22-3, c200 and NS5. Confirmation of specific antibody to HCV was by a modification o
Development of a point mutation assay for the detection of human cytomegalovirus UL97 mutations associated with ganciclovir resistance.: J Virol Methods. 1997 Nov;68(2):225-34. Unique Identifier : AIDSLINE MED/98049281; Bowen EF; Johnson MA; Griffiths PD; Emery VC; Department of Virology, Royal Free Hospital School of Medicine,; London, UK.; A point mutation assay was developed to detect the quantitative prevalence of mutations at codons 460 (M to I; M to V), 520 (H to Q), 594 (A to V) and 595 (L to F; L to S) within the UL97 gene of human cytomegalovirus which segregate with ganciclovir resistance. Synthetic mixtures
Cytokines in the brain during viral infection: clues to HIV-associated dementia.: J Clin Invest. 1997 Dec 15;100(12):2948-51. Unique Identifier : AIDSLINE MED/98064050; Griffin DE; Department of Molecular Microbiology and Immunology, Johns Hopkins; University School of Hygiene and Public Health, Baltimore, Maryland; 21205, USA. dgriffin@jhsph.edu
Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences.: J Clin Invest. 1997 Dec 15;100(12):3027-35. Unique Identifier : AIDSLINE MED/98064060; Karachunski PI; Ostlie NS; Okita DK; Conti-Fine BM; Department of Biochemistry, College of Biological Sciences, University; of Minnesota, St. Paul, Minnesota 55108, USA.; T cell tolerization prevents and improves T cell-mediated experimental autoimmune diseases. We investigated here whether similar approaches could be used for antibody (Ab)-mediated autoimmune diseases. Myasthenia gravis, caused by IgG Ab against muscle acetylcholine receptor (AChR), is perhaps the best characterized o
Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.: J Clin Invest. 1997 Dec 15;100(12):3083-92. Unique Identifier : AIDSLINE MED/98064066; Henderson WR Jr; Chi EY; Albert RK; Chu SJ; Lamm WJ; Rochon Y; Jonas M; Christie PE; Harlan JM; Department of Medicine, University of Washington, Seattle, Washington; 98195, USA.; Immunized mice after inhalation of specific antigen have the following characteristic features of human asthma: airway eosinophilia, mucus and Th2 cytokine release, and hyperresponsiveness to methacholine. A model of late-phase allergic pulmonary inflammation in ovalbumin-sensitized mice was used to address the role o
Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines.: J Clin Invest. 1997 Dec 15;100(12):3154-63. Unique Identifier : AIDSLINE MED/98064074; Soderberg-Naucler C; Fish KN; Nelson JA; Department of Molecular Microbiology and Immunology, Oregon Health; Sciences University, Portland, Oregon 97201-3098, USA.; Monocytes/macrophages are key cells in the pathogenesis of human cytomegalovirus (HCMV). Although HCMV infection in monocytes is restricted to early events of gene expression, productive infection has been demonstrated in differentiated macrophages in vitro. We examined the cellula
Social barriers to recognizing HIV/AIDS in older adults.: J Gerontol Nurs. 1997 Nov;23(11):17-21. Unique Identifier : AIDSLINE MED/98077954; Mueller MR; Medical Anthropology Program, University of California, San Francisco; 94143-0850, USA.
Intestinal parasitic infections in patients with malignancy.: J Diarrhoeal Dis Res. 1997 Jun;15(2):71-4. Unique Identifier : AIDSLINE MED/98024698; Rudrapatna JS; Kumar V; Sridhar H; Department of Microbiology, Kidwai Memorial Institute of Oncology,; Bangalore, India.; The frequency of intestinal parasitic infections was studied retrospectively in 1,029 cancer patients presenting with symptoms of diarrhoea. Intestinal parasites were diagnosed by stool examination, using both the direct and concentration techniques and also the modified acid fast stain. Parasitic infection was found
HIV-positive patient presented with giant molluscum contagiosum of the eyelid.: J Indian Med Assoc. 1997 Jun;95(6):202. Unique Identifier : AIDSLINE MED/98081961; Chattopadhyay DN; Basak SK; Ghose S; Department of Ophthalmology, NRS Medical College and Hospital,; Calcutta.
Increase in endocervical CD4 lymphocytes among women with nonulcerative sexually transmitted diseases.: J Infect Dis. 1998 Jan;177(1):167-74. Unique Identifier : AIDSLINE MED/98078993; Levine WC; Pope V; Bhoomkar A; Tambe P; Lewis JS; Zaidi AA; Farshy CE; Mitchell S; Talkington DF; Division of Sexually Transmitted Disease Prevention, National Center; for HIV, STD, and TB Prevention, Centers for Disease Control and; Prevention, and Fulton County Health Department, Atlanta, Georgia; 30333, USA.; To assess associations of nonulcerative sexually transmitted diseases (STDs) with human immunodeficiency virus HIV)-susceptible leukocytes on female genital mucosa, cervicovaginal specimens from 32 HIV-negative STD clinic patients with gonorrhea, chlamydial infection, or trichomoniasis were compared with specimens fro
Mucosally transmitted feline immunodeficiency virus induces a CD8+ antiviral response that correlates with reduction of cell-associated virus.: J Infect Dis. 1998 Jan;177(1):18-25. Unique Identifier : AIDSLINE MED/98078974; Bucci JG; English RV; Jordan HL; Childers TA; Tompkins MB; Tompkins WA; Department of Microbiology, Pathology, and Parasitology, College of; Veterinary Medicine, North Carolina State University, Raleigh 27606,; USA.; Intravaginal inoculation of cats with feline immunodeficiency virus (FIV) results in acute systemic infection accompanied by a strong CD8+ immune response that inhibits viral replication. CD8+ anti-FIV activity, revealed by increased FIV replication in peripheral blood mononuclear cells (PBMC) depleted of CD8+ lymphoc
Pneumocystis carinii glycoprotein A inhibits surfactant phospholipid secretion by rat alveolar type II cells.: J Infect Dis. 1998 Jan;177(1):182-7. Unique Identifier : AIDSLINE MED/98078995; Lipschik GY; Treml JF; Moore SD; Beers MF; Pulmonary Division, Allegheny University Hospitals-Medical College of; Pennsylvania Division, Philadelphia, USA.; Pneumocystis carinii pneumonia (PCP) remains a major cause of morbidity in AIDS. The pathogenesis of PCP is poorly understood, but evidence of surfactant abnormalities is mounting. The role of the major surface glycoprotein of P. carinii, gpA, in producing surfactant abnormalities was investigated. Rat type II pneumoc
Human herpesvirus 8 detection in nasal secretions and saliva.: J Infect Dis. 1998 Jan;177(1):213-6. Unique Identifier : AIDSLINE MED/98079000; Blackbourn DJ; Lennette ET; Ambroziak J; Mourich DV; Levy JA; Department of Medicine, University of California, San Francisco,; 94143-1270, USA.; The presence of human herpesvirus 8 (HHV-8) was determined by polymerase chain reaction (PCR) in nasal secretions and saliva from 14 HHV-8-seropositive persons, including 8 Kaposi s sarcoma patients: 7 were human immunodeficiency virus type 1-infected, 6 of whom were asymptomatic. HHV-8 was detected in one or both bod
Association of CD4 cell depletion and elevated blood and seminal plasma human immunodeficiency virus type 1 (HIV-1) RNA concentrations with genital ulcer disease in HIV-1-infected men in Malawi.: J Infect Dis. 1998 Jan;177(1):224-7. Unique Identifier : AIDSLINE MED/98079003; Dyer JR; Eron JJ; Hoffman IF; Kazembe P; Vernazza PL; Nkata E; Costello Daly C; Fiscus SA; Cohen MS; Department of Medicine, University of North Carolina at Chapel Hill,; 27599-7030, USA.; CD4 cell counts and blood plasma and seminal plasma human immunodeficiency virus type 1 (HIV-1) concentrations were compared in HIV-1 RNA-seropositive men with urethritis and with or without genital ulcer disease (GUD). GUD was associated with lower CD4 cell counts (median, 258 vs. 348/microL) and increased blood plas
Horizontal and vertical transmission of human immunodeficiency virus type 1 dual infections caused by viruses of subtypes B and C.: J Infect Dis. 1998 Jan;177(1):227-31. Unique Identifier : AIDSLINE MED/98079004; Janini LM; Tanuri A; Schechter M; Peralta JM; Vicente AC; Dela Torre N; Pieniazek NJ; Luo CC; Ramos A; Soriano V; Schochetman G; Rayfield MA; Pieniazek D; Division of AIDS, STD, TB Laboratory Research, Centers for Disease; Control and Prevention, Atlanta, Georgia 303