1998

Organizational factors related to AIDS/HIV education in outpatient substance abuse treatment units.: J Health Soc Policy. 1998;9(3):1-13. Unique Identifier : AIDSLINE MED/98063622; Clapp JD; School of Social Work, University of Nevada, Las Vegas 89154, USA.; The association of HIV and AIDS with intravenous drug use is well documented. Given this, substance abuse treatment providers must figure prominently in any effective national response to HIV/AIDS. The strategies employed by human service managers to address AIDS may be important in explaining how substance abuse trea
The media and AIDS: health elite perspectives of coverage.: J Health Soc Policy. 1998;9(3):45-69. Unique Identifier : AIDSLINE MED/98063625; Backstrom CH; Robins LS; Department of Political Science, University of Minnesota, USA.; Most writers assessing AIDS have been critical of the media s coverage of this epidemic. To ascertain the views of key elites on media coverage of AIDS, the authors surveyed chief state public health officers, chairs of legislative health committees, and directors of hospital associations. In general, these groups ten
The odds grow longer. Doctors had hoped by now to have eliminated the AIDS virus from some patients. No such luck.: Time. 1997 Nov 24;150(22):84. Unique Identifier : AIDSLINE MED/98077150; Gorman C
AIDS drugs fail a test. New studies show they don't eliminate all HIV.: Newsweek. 1997 Nov 24;130(21):61. Unique Identifier : AIDSLINE MED/98077123; Cowley G
AIDS comes to small-town America.: US News World Rep. 1997 Nov 10;123(18):52-5. Unique Identifier : AIDSLINE MED/98063565; Brownlee S; McDonald M; Ackerman E
A typological approach to the study of rural HIV service delivery networks [see comments]: J Rural Health. 1997 Summer;13(3):216-25. Unique Identifier : AIDSLINE MED/98072136; Berry DE; McKinney MM; Marconi KM; Community Health Solutions Inc., Richmond, KY 40475, USA.; Despite the rapid growth of AIDS cases in nonmetropolitan areas, little is known about the characteristics and needs of HIV-positive rural residents or how rural areas are responding to the epidemic. This paper proposes a typology for distinguishing among rural environments and examining variations in HIV service netw
Delivering care to rural HIV/AIDS patients [see comments]: J Rural Health. 1997 Summer;13(3):226-36. Unique Identifier : AIDSLINE MED/98072137; Topping S; Hartwig LC; Cecil G. Sheps Center for Health Services Research, Chapel Hill, NC; 27599, USA.; With HIV/AIDS on the rise in rural areas, health care providers must find ways of delivering care with little or no increase in resource support. This paper examines the evolution of a rural HIV/AIDS alliance using a life cycle model to identify each stage of the alliance development and the specific issues associated
AIDS in rural America [comment]: J Rural Health. 1997 Summer;13(3):237-9. Unique Identifier : AIDSLINE MED/98072138; Cohn SE; University of Rochester Medical Center, NY 14642, USA.
HIV and blood transfusion in sub-Saharan Africa.: Transfus Sci. 1997 Jun;18(2):167-79. Unique Identifier : AIDSLINE MED/98052799; Fleming AF; University Teaching Hospital, Lusaka, Zambia.; Blood transfusion services were poorly developed until the mid 1980s in most of sub-Saharan Africa, and were unable to provide adequate supplies of blood with acceptable safety. The pandemic of HIV was recognized seroepidemiologically from 1985 onwards. Blood transfusion was contributing from 10 to 15% to transmission
Gene therapy for AIDS.: Transfus Sci. 1997 Jun;18(2):277-89. Unique Identifier : AIDSLINE MED/98052812; Sorg T; Methali M; Department of Gene Therapy, Transgene, Strasbourg, France.; The absence of effective treatments makes AIDS one obvious candidate among the infectious diseases which might be treated by somatic gene therapy. Since HIV1 predominantly infects cells of the haematopoietic system, multipotent stem cells or more mature CD4+ cells constitute potential targets for the introduction of a
Therapeutic options for HIV-associated bodyweight loss. A risk-benefit analysis.: Drug Saf. 1997 Nov;17(5):290-302. Unique Identifier : AIDSLINE MED/98053261; Stosor V; Roenn JV; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois, USA.; Involuntary bodyweight loss, a common complication of infection with HIV, is an indicator of poor prognosis and decreased survival. Because of the multifactorial pathogenesis of HIV-related wasting, emerging therapies are directed at the multiple proposed mechanisms of involuntary bodyweight loss. The initial evaluati
Abdominal CT features and survival in acquired immunodeficiency.: Acta Radiol. 1997 Nov;38(6):970-7. Unique Identifier : AIDSLINE MED/98056633; Knollmann FD; Maurer J; Grunewald T; Schedel H; Vogl TJ; Pohle HD; Felix R; Department of Radiology, Virchow Hospital, Faculty of Medicine,; Humboldt University of Berlin, Germany.; PURPOSE: HIV-infected patients show a high incidence of abdominal disease. This investigation was made to determine whether abdominal CT provided prognostically relevant information in these patients. MATERIAL AND METHODS: Images from 533 abdominal CT examinations in 339 HIV-infected patients were retrospectively revi
Role of viral infection in porphyria cutanea tarda.: Photodermatol Photoimmunol Photomed. 1997 Jun;13(3):75-7. Unique Identifier : AIDSLINE MED/98039787; Lim HW; Department of Dermatology, Henry Ford Hospital, Detroit, MI; 48202-2689, USA.; HIV infection is associated with abnormal porphyrin metabolism. While HCV infection alone is thus far not associated with significant abnormal porphyrin levels, it does contribute to further elevation of porphyrin levels in patients already infected with HIV. These infections alone are not sufficient to induce the dev
UVB and PUVA therapies in HIV patients: are they safe?: Photodermatol Photoimmunol Photomed. 1997 Jun;13(3):91-2. Unique Identifier : AIDSLINE MED/98039793; Beer JZ; Zmudzka BZ; Food and Drug Administration, Rockville, Maryland 20857, USA.
Intracellular immunization of rhesus CD34+ hematopoietic progenitor cells with a hairpin ribozyme protects T cells and macrophages from simian immunodeficiency virus infection.: Blood. 1997 Dec 15;90(12):4822-31. Unique Identifier : AIDSLINE MED/98052537; Rosenzweig M; Marks DF; Hempel D; Heusch M; Kraus G; Wong-Staal F; Johnson RP; New England Regional Primate Research Center, Harvard Medical School,; Southborough, MA 01772, USA.; Evaluation of candidate genes for stem cell gene therapy for acquired immunodeficiency syndrome (AIDS) has been limited by the difficulty of supporting in vitro T-cell differentiation of genetically modified hematopoietic progenitor cells. Using a novel thymic stromal culture technique, we evaluated the ability of a h
Robust, but transient expression of adeno-associated virus-transduced genes during human T lymphopoiesis.: Blood. 1997 Dec 15;90(12):4854-64. Unique Identifier : AIDSLINE MED/98052540; Gardner JP; Zhu H; Colosi PC; Kurtzman GJ; Scadden DT; Division of Experimental Hematology, AIDS Research Center, MGH Cancer; Center, Massachusetts General Hospital, Harvard Medical School,; Boston, MA 02129, USA.; Recombinant adeno-associated viruses (rAAV) have been proposed to be gene transfer vehicles for hematopoietic stem cells with advantages over other virus-based systems due to their high titers and relative lack of dependence on cell cycle for target cell integration. We evaluated rAAV vector containing a LacZ reporter
Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen.: Blood. 1997 Dec 15;90(12):4894-900. Unique Identifier : AIDSLINE MED/98052544; Gaidano G; Gloghini A; Gattei V; Rossi MF; Cilia AM; Godeas C; Degan M; Perin T; Canzonieri V; Aldinucci D; Saglio G; Carbone A; Pinto A; Division of Internal Medicine, Department of Medical Sciences,; University of Torino at Novara, Novara, Italy.; Primary effusion lymphoma (PEL) represents a novel B-cell non-Hodgkin s lymphoma (NHL) type associated with Kaposi s sarcoma-associated herpesvirus infection and typically growing as lymphomatous effusions in the body cavities. The precise B-cell subset from which PEL originates as
Repression of transcription from the human T-cell leukemia virus type I long terminal repeat and cellular gene promoters by wild-type p53.: Blood. 1997 Dec 15;90(12):4924-32. Unique Identifier : AIDSLINE MED/98052548; Mori N; Kashanchi F; Prager D; Division of Hematology/Oncology, University of California at Los; Angeles School of Medicine, Los Angeles, CA, USA.; Human T-cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells both in vivo and in vitro. However, the long latency period between infection and development of ATL, as well as the small fraction of the infected population that actually develops this disease, su
Idiopathic CD4+ T-lymphocytopenia [editorial; comment]: Intern Med. 1997 Nov;36(11):759. Unique Identifier : AIDSLINE MED/98052237; Torikai K
Idiopathic CD4+ T-lymphocytopenia with Bowen's disease [see comments]: Intern Med. 1997 Nov;36(11):822-4. Unique Identifier : AIDSLINE MED/98052251; Hayashi T; Hinoda Y; Takahashi T; Adachi M; Miura S; Izumi T; Kojima H; Yano S; Imai K; First Department of Internal Medicine, Sapporo Medical University; School of Medicine.; A 39-year-old man with Bowen s disease was troubled with multiple molluscum contagiosum over the trunk and lower extremities. Subsequently oral candidiasis was complicated. Laboratory examination revealed lymphocytopenia and a decrease in the CD4/CD8 ratio. His CD4+ T-lymphocyte count was only 187 cells/microl one tim
[Serological diagnosis in HIV infection]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jul-Sep;42(3):125-30. Unique Identifier : AIDSLINE MED/98030155; Negut EA; Usein CR; Institutul Cantacuzino.
[The pathogenesis of viral hepatitis C]: Bacteriol Virusol Parazitol Epidemiol. 1997 Jul-Sep;42(3):167-72. Unique Identifier : AIDSLINE MED/98030164; Tecu C; Institutul Cantacuzino.
Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: prospective multicentre study. Swiss HIV Cohort Study.: BMJ. 1997 Nov 8;315(7117):1194-9. Unique Identifier : AIDSLINE MED/98054931; Egger M; Hirschel B; Francioli P; Sudre P; Wirz M; Flepp M; Rickenbach M; Malinverni R; Vernazza P; Battegay M; Department of Social and Preventive Medicine, University of Berne,; Switzerland.; OBJECTIVES: To examine trends in disease progression and survival among patients enrolled in the Swiss HIV cohort study during 1988-96 and to assess the influence of new antiretroviral combination therapies. DESIGN: Prospective multicentre study, with follow up visits planned at six monthly intervals. SETTING: Seven H
Is the clinical course of HIV infection changing? Finding is disheartening [letter]: BMJ. 1997 Nov 8;315(7117):1236. Unique Identifier : AIDSLINE MED/98054956; Porter K
Is the clinical course of HIV infection changing? Exclusion of people not followed up for 12 months may have biased results [letter]: BMJ. 1997 Nov 8;315(7117):1236-7. Unique Identifier : AIDSLINE MED/98054957; Law MG; Kaldor JM
Is the clinical course of HIV infection changing? Study's censoring strategy may be source of bias [letter]: BMJ. 1997 Nov 8;315(7117):1237. Unique Identifier : AIDSLINE MED/98054958; Cozzi Lepri A; Phillips AN; Pezzotti P; Rezza G
Sexually transmitted diseases among teenagers in England and Wales.: Commun Dis Rep CDR Rev. 1997 Nov 14;7(12):R173-8. Unique Identifier : AIDSLINE MED/98055854; Connor N; Catchpole M; Rogers PA; Macdonald N; Mc Garrigle C; Simms I; Radcliffe L; Gilbart V; Clarke SE; Webster J; Nicoll A; PHLS AIDS and STD Centre, PHLS Communicable Disease Surveillance; Centre, London. anicoll@phls.co.uk; A profile of sexually transmitted diseases (STDs) and HIV infections among teenagers in England and Wales was obtained from reports of newly diagnosed STDs among teenagers attending genitourinary medicine (GUM) clinics in 1995, laboratory reports of newly diagnosed HIV infections between 1985 when reporting began and
CD4 cell counts of 200 x 10(6)/1 or below in natural history studies and surveillance: is one enough or are two better?: Commun Dis Rep CDR Rev. 1997 Nov 14;7(12):R179-85. Unique Identifier : AIDSLINE MED/98055855; Easterbrook PJ; Yu LM; McLean K; Hawkins D; Gazzard B; HIV Epidemiology Unit, Department of HIV/Genitourinary Medicine,; Charing Cross Hospital.; A retrospective cohort study was performed to examine the extent and clinical significance of misclassification associated with using the current United States AIDS case defining category of an initial CD4 count
[Study by the Professional Organization of German Transfusion Physicians on epidemiology of HIV- and hepatitis infections in blood donors]: Beitr Infusionsther Transfusionsmed. 1997;34:1-4. Unique Identifier : AIDSLINE MED/98019468; Gluck D; Maurer C; Kubanek B; Studiensekretariat des Berufsverbands Deutscher Transfusionsmediziner; e. V., Ulm, Deutschland.; The frequency of the seromarkers of HIV, HCV, and HBV in the donor population from all donor centers in Germany became available from the multicenter study of the transfusion services. From these data the risk of virus transmission by blood products can be estimated at 1:1 million
[Routine PCR screening for HBV, HCV and HIV-I genome in a large blood donation services--experiences and initial results]: Beitr Infusionsther Transfusionsmed. 1997;34:21-5. Unique Identifier : AIDSLINE MED/98019472; Schottstedt V; Tuma W; Bunger G; Lakenberg P; DRK-Blutspendedienst Nordrhein-Westfalen, Institut Hagen, Deutschland.; We adapted the PCR method to screen up to 3,000 blood donations per day for HBV, HCV, and HIV-1 contamination. Concerning logistics: The first step is the generation of 3 identical microtiter plates (PT) by using the self-validated automatic sample processor with disposable tips. Using the first PT, we pooled up to 60
[Plasma donor screening and product safety]: Beitr Infusionsther Transfusionsmed. 1997;34:31-6. Unique Identifier : AIDSLINE MED/98019474; Storch H; Ponsel G; Igel H; Worofka R; IMMUNO GmbH Heidelberg.; In addition to the specific virus reduction and inactivation procedures during the manufacturing process, the thorough selection of the source material is an essential factor for the product safety of plasmaderivatives. Screening of donors, inventory hold, and plasma pool testing by PCR are important aspects in raisin
Efficient gene transfer into primary and immortalized human fetal glial cells using adeno-associated virus vectors: establishment of a glial cell line with a functional CD4 receptor.: J Neurovirol. 1997 Oct;3(5):322-30. Unique Identifier : AIDSLINE MED/98039722; Keir SD; Miller J; Yu G; Hamilton R; Samulski RJ; Xiao X; Tornatore C; Laboratory of Molecular Medicine and Neuroscience, National Institute; of Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, Maryland 20892, USA.; Adeno associated virus (AAV) is a non-pathogenic dependent parvovirus with a broad host range, capable of high levels of transduction and stable integration into the host cell genome. We have investigated the potential for using AAV as a vector for gene transfer into glial cells of the human fetal nervous system. Reco
HIV-1 LTR DNA sequence variation in brain-derived isolates.: J Neurovirol. 1997 Oct;3(5):331-41. Unique Identifier : AIDSLINE MED/98039723; Corboy JR; Garl PJ; University of Colorado Health Sciences Center, Department of; Neurology, Denver 80262, USA.; Isolates of human immunodeficiency virus (HIV-1) derived from the central nervous system (CNS) display properties distinctive from blood-derived isolates, including a high incidence of macrophage tropism in CNS isolates. Macrophage tropism is a result, in part, of DNA sequence variation in the HIV-1 envelope glycoprot
Regulation of glutathione and cell toxicity following exposure to neurotropic substances and human immunodeficiency virus-1 in vitro.: J Neurovirol. 1997 Oct;3(5):342-9. Unique Identifier : AIDSLINE MED/98039724; Koutsilieri E; Gotz ME; Sopper S; Sauer U; Demuth M; ter Meulen V; Riederer P; Department of Psychiatry, Clinical Neurochemistry, Julius Maximilians; University, Wurzburg, Germany.; The aim of the present study was to assess the toxic potential of drugs of abuse and other neuropharmacological agents in the pathogenesis of AIDS dementia complex (ADC), the neurological complication of AIDS. Neuroblastoma and glioblastoma cell lines expressing the dopamine transp
Semliki Forest virus infection leads to increased expression of adhesion molecules on splenic T-cells and on brain vascular endothelium.: J Neurovirol. 1997 Oct;3(5):350-60. Unique Identifier : AIDSLINE MED/98039725; Soilu-Hanninen M; Roytta M; Salmi AA; Salonen R; Turku Immunology Centre, University of Turku, Finland.; Semliki Forest virus A7 (SFV-A7) is a neurotropic alphavirus that leads to an asymptomatic encephalitis in adult immunocompetent mice. We studied the expression of leukocyte and endothelial cell adhesion molecules in the spleen and in the central nervous system (CNS) during SFV-A7 infection. Kinetics of the expression
Neuropathology in cats experimentally infected with feline immunodeficiency virus: a morphological, immunocytochemical and morphometric study.: J Neurovirol. 1997 Oct;3(5):361-8. Unique Identifier : AIDSLINE MED/98039726; Poli A; Abramo F; Di Iorio C; Cantile C; Carli MA; Pollera C; Vago L; Tosoni A; Costanzi G; Department of Animal Pathology, University of Pisa, Italy.; Neuropathological changes have been described associated with feline immunodeficiency virus (FIV) infection. The objective of our study was to characterize the lesions found in the brain and spinal cord of experimentally FIV-infected cats and to quantify, by morphometric analysis, the intensity of gliosis found in the
HIV-related interstitial lung disease.: Curr Opin Pulm Med. 1995 Sep;1(5):383-91. Unique Identifier : AIDSLINE MED/98029387; Semenzato G; Agostini C; Padua University School of Medicine, Italy.; The progressive breakdown of the cell-mediated immunity, which characterizes the natural history of HIV infection, invariably leads to the development of miscellaneous opportunistic infections or neoplasms involving a number of tissues, including the respiratory tract. In particular, given the extent and the severity
Methodological considerations in estimating speed of cognitive operations.: J Int Neuropsychol Soc. 1995 Jan;1(1):3-9. Unique Identifier : AIDSLINE MED/98042772; Becker JT; Caldararo R; Baddeley AD; Dew MA; Heindel WC; Banks G; Dorst SK; Lopez OL; Department of Psychiatry, University of Pittsburgh Medical Center, PA; 15213, USA.; Individuals infected with Human Immunodeficiency Virus (HIV) and having cognitive impairment have been described as having slow mentation. Data supporting this proposition come from a variety of sources, including Sternberg s (1966) item recognition memory task. The procedure nominally provides an index of speed of me
The HNRC 500--neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center.: J Int Neuropsychol Soc. 1995 May;1(3):231-51. Unique Identifier : AIDSLINE MED/98042788; Heaton RK; Grant I; Butters N; White DA; Kirson D; Atkinson JH; McCutchan JA; Taylor MJ; Kelly MD; Ellis RJ; et al; University of California at San Diego, Dept. of Psychiatry, La Jolla,; 92093, USA.; The present study examined neuropsychological (NP) functioning and associated medical, neurological, brain magnetic resonance imaging (MRI), and psychiatric findings in 389 nondemented males infected with Human Immunodeficiency Virus-Type 1 (HIV-1), and in 111 uninfected controls. Using a comprehensive NP test battery
Neuropsychological studies of asymptomatic human immunodeficiency virus-type-1 infected individuals. The HNRC Group. HIV Neurobehavioral Research Center.: J Int Neuropsychol Soc. 1995 May;1(3):304-15. Unique Identifier : AIDSLINE MED/98042795; White DA; Heaton RK; Monsch AU; Department of Psychiatry, University of California, San Diego, La; Jolla 92093, USA.; The current review was conducted to address the ongoing debate regarding the presence or absence of neuropsychological impairment in asymptomatic HIV-Type 1 (HIV-1) seropositive individuals. Results were summarized from 57 studies that compared the performances of seropositive asymptomatic and seronegative individuals
Delayed recognition memory span in HIV-1 infection.: J Int Neuropsychol Soc. 1995 Nov;1(6):575-80. Unique Identifier : AIDSLINE MED/98042815; Martin EM; Pitrak DL; Pursell KJ; Mullane KM; Novak RM; Department of Psychiatry, University of Illinois-Chicago 60612, USA.; eileen.m.martin@uic.edu; We administered a spatial version of the Delayed Recognition Span Test (DRST), a working memory task performed abnormally by patients with basal ganglia disease, to a group of 96 HIV-seropositive and 83 seronegative subjects with a high prevalence of substance abuse. For comparison purposes, we also administered the S
Relationship between psychiatric disease and neuropsychological impairment in HIV seropositive individuals.: J Int Neuropsychol Soc. 1995 Nov;1(6):581-8. Unique Identifier : AIDSLINE MED/98042816; Bix BC; Glosser G; Holmes W; Ballas C; Meritz M; Hutelmyer C; Turner J; Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania; 19146, USA.; Neuropsychological impairment and DSM-III-R Axis I psychiatric diagnoses were evaluated in a heterogenous group of HIV seropositive individuals and seronegative individuals with similar risk factors for HIV infection. Neuropsychological and psychiatric disorders were common in the HIV seropositive group, but there wer
Neuropsychological deficits in HIV-1 seropositive and seronegative intravenous drug users (IVDUs): a follow-up study.: J Int Neuropsychol Soc. 1996 Mar;2(2):126-33. Unique Identifier : AIDSLINE MED/98042766; Hestad K; Aukrust P; Ellertsen B; Klove H; Department of Biological and Medical Psychology, University of Bergen,; Norway.; Human immunodeficiency virus type 1 (HIV-1) seropositive AIDS free and HIV-1 seronegative intravenous drug users were tested twice with a comprehensive neuropsychological test battery. Only minor group differences were found. Memory difficulties were the most pronounced difference with lower scores in the HIV-1 seropo
Subjective complaints of cognitive symptoms are related to psychometric findings of memory deficits in patients with HIV-1 infection.: J Int Neuropsychol Soc. 1996 May;2(3):219-25. Unique Identifier : AIDSLINE MED/98042756; Poutiainen E; Elovaara I; Department of Neurology, University of Helsinki, Finland.; Eighty-five subjects at various stages of human immunodeficiency virus (HIV-1) infection and 39 seronegative controls underwent neurological and neuropsychological evaluation to assess the relationship between cognitive test results and subjective complaints (cognitive, affective, motor, and other). The effect of psyc
Comparison of hydroxychloroquine with zidovudine in asymptomatic patients infected with human immunodeficiency virus type 1.: Clin Ther. 1997 Sep-Oct;19(5):913-23. Unique Identifier : AIDSLINE MED/98046590; Sperber K; Chiang G; Chen H; Ross W; Chusid E; Gonchar M; Chow R; Liriano O; Division of Clinical Immunology, Mount Sinai Medical Center, New York,; New York, USA.; Hydroxychloroquine (HCQ), an antimalarial agent used to treat patients with autoimmune diseases, has been shown to suppress human immunodeficiency virus type 1 (HIV-1) replication in T cells and monocytes in vitro by inhibiting posttranscriptional modification of the virus. An initial randomized, placebo-controlled cl
Sendai virus-based expression of HIV-1 gp120: reinforcement by the V(-) version.: Genes Cells. 1997 Jul;2(7):457-66. Unique Identifier : AIDSLINE MED/98031879; Yu D; Shioda T; Kato A; Hasan MK; Sakai Y; Nagai Y; Department of Viral Infection, Institute of Medical Science,; University of Tokyo, Japan.; BACKGROUND: We have established a system for recovering Sendai virus (SeV), a nonsegmented negative strand RNA virus, entirely from cDNA at an extremely high rate, and have succeeded in creating a V(-) SeV whose gene expression was greatly enhanced by the deletion of the nonessential V gene. Because of its extreme med
Stigmatization, discrimination and fear of AIDS in Greece: implications for health policy.: Ethn Health. 1996 Dec;1(4):359-71. Unique Identifier : AIDSLINE MED/98051762; Chliaoutakis J; Trakas DJ; Department of Health Visiting, Technological Educational Institution; of Athens, Greece.; A prospective health-education research project about AIDS knowledge and attitudes towards AIDS was conducted in Athens and nine adjacent municipalities in west Attica, Greece . Socioeconomic and demographic data, AIDS knowledge, and
Differential survival in blacks and Hispanics with AIDS.: Ethn Health. 1996 Dec;1(4):373-82. Unique Identifier : AIDSLINE MED/98051763; Murrain M; School of Natural Science, Hampshire College, Amhurst, MA 01002, USA.; OBJECTIVE: The object of this study was to investigate whether there are differences in survival by ethnicity in people with AIDS. DESIGN: The CDC Public Access Dataset was analysed. To estimate survival more accurately, a cohort of individuals diagnosed in 1987 was chosen from the dataset. Using this analysis, probab
Evaluating the role of Th0 and Th1 clones in autoimmune thyroid disease by use of Hu-SCID chimeras.: Clin Immunol Immunopathol. 1997 Dec;85(3):253-64. Unique Identifier : AIDSLINE MED/98063345; Fisfalen ME; Soltani K; Kaplan E; Palmer EM; van Seventer GA; Straus FH; Diaz M; Ober C; DeGroot LJ; Department of Medicine, University of Chicago, Illinois 60637, USA.; To study the role of Th0 and Th1 cells in autoimmune thyroid disease, thyroid tissues from patients with Graves disease (GD), Hashimoto s thyroiditis (HT), and colloid nodular disease were xenografted into SCID mice, followed by ip injection of peripheral blood mononuclear cells (PBMC), T cell lines, and T cell clone
Lymphocyte phenotyping in infants: maturation of lymphocyte subpopulations and the effects of HIV infection.: Clin Immunol Immunopathol. 1997 Dec;85(3):273-81. Unique Identifier : AIDSLINE MED/98063347; Rich KC; Brambilla D; Pitt J; Moye J; Cooper E; Hillyer G; Mendez H; Fowler MG; Landay A; University of Illinois at Chicago, Illinois 60612, USA.; Changes in the distribution of lymphocyte subpopulations in infants with perinatally acquired HIV infection are confounded by the rapid changes that are the result of normal maturation of the immune system. We describe the changes in seven lymphocyte phenotypes (CD3+ CD4+, CD3+ CD8+, CD8+ HLA- DR+, CD8+ CD38+, CD8+ CD
Role of T-cell subsets in acute and persistent E-55+ murine leukemia virus infection in susceptible progressor and resistant long-term nonprogressor mouse strains. Women and Infants Transmission Study.: Clin Immunol Immunopathol. 1997 Dec;85(3):282-8. Unique Identifier : AIDSLINE MED/98063348; Avidan N; Sieck TG; Blank KJ; Department of Pathology and Laboratory Medicine, Allegheney University; of the Health Sciences, Philadelphia, Pennsylvania 19102, USA.; Previous studies from this laboratory have demonstrated that E-55+MuLV-infected BALB/c-H-2k (BALB.K) mice progress to develop thymic lymphoma about 7 months after infection whereas infected C57BL/10-H-2k (B10.BR) mice are long-term nonprogressors that fail to develop disease even after 2 years of infection. Both resis
Patterns of in vitro anti-human immunodeficiency virus type 1 antibody production in long-term nonprogressors.: Clin Immunol Immunopathol. 1997 Dec;85(3):320-3. Unique Identifier : AIDSLINE MED/98063352; Rusconi S; Berlusconi A; Papagno L; Colombo MC; De Maddalena C; Riva A; Bagnarelli P; Balotta C; Galli M; Istituto di Malattie Infettive, Universita di Milano, Ospedale Luigi; Sacco, Italy. rusconi@imiucca.csi.unimi.it; With the aim of evaluating the specific pattern of in vitro antibody production (IVAP) in human immunodeficiency virus type 1 HIV-1)-infected long-term non-progressors (LTNPs), we tested 20 subjects who had remained asymptomatic for more than 8 years with a CD4+ cell count higher than 500/microliter and 59 patients at
Expression of a newly identified phosphate transporter/retrovirus receptor in human SaOS-2 osteoblast-like cells and its regulation by insulin-like growth factor I.: Endocrinology. 1997 Dec;138(12):5202-9. Unique Identifier : AIDSLINE MED/98049370; Palmer G; Bonjour JP; Caverzasio J; Department of Medicine, University of Geneva, Switzerland.; The cell surface receptor for gibbon ape leukemia virus (Glvr-1) was recently demonstrated to serve normal cellular functions as a sodium-dependent phosphate (NaPi) transporter. This protein belongs to a newly identified phosphate transporter/retrovirus receptor gene family distinct from renal type I and II NaPi trans
Changes in 1,25-(OH)2D3 synthesis and its receptor expression in spleen cell subpopulations of mice infected with LPBM5 retrovirus.: Endocrinology. 1997 Dec;138(12):5505-10. Unique Identifier : AIDSLINE MED/98049405; Nguyen TM; Pavlovitch J; Papiernik M; Guillozo H; Walrant-Debray O; Pontoux C; Garabedian M; CNRS, URA 583, Universite Paris V, Hopital Saint-Vincent de Paul,; France.; This study examines the influence of chronic retroviral infection of mice with a LPBM5 virus mixture on the paracrine system involving immune cells and 1,25-(OH)2D3 in the spleen. Plasma ionized calcium, 25-(OH)D and 1,25-(OH)2D of infected mice were unchanged. In contrast, the specific binding of 1,25-(OH)2D3 to sple
[The clinical concept of spondyloarthropathies]: Fortschr Med. 1997 Sep 20;115(26):44-5. Unique Identifier : AIDSLINE MED/98011133; Braun J; Sieper J
Non-Hodgkin's lymphoma among people with AIDS: incidence, presentation and public health burden. AIDS/Cancer Study Group.: Int J Cancer. 1997 Nov 27;73(5):645-50. Unique Identifier : AIDSLINE MED/98058682; Cote TR; Biggar RJ; Rosenberg PS; Devesa SS; Percy C; Yellin FJ; Lemp G; Hardy C; Geodert JJ; Blattner WA; Viral Epidemiology Branch, Division of Cancer Etiology, National; Cancer Institute, Rockville, MD, USA.; We describe the anatomic and histologic presentation and prognosis of non-Hodgkin s lymphoma (NHL) among people with AIDS PWA) and determine their contribution to the NHL burden. We linked AIDS and cancer registries in selected areas of the United State
Adolescents with psychiatric disorders and the risk of HIV.: J Am Acad Child Adolesc Psychiatry. 1997 Nov;36(11):1609-17. Unique Identifier : AIDSLINE MED/98056957; Brown LK; Danovsky MB; Lourie KJ; DiClemente RJ; Ponton LE; Department of Child and Family Psychiatry, Rhode Island Hospital,; Providence 02903, USA.; OBJECTIVE: To review literature relevant to human immunodeficiency virus (HIV)-associated risk behaviors among adolescents with psychiatric disorders and psychological influences on risk behaviors. METHOD: This report is based on review of 66 articles, which comprise all of the relevant literature in the English langu
The infection control practices of general dental practitioners.: Infect Control Hosp Epidemiol. 1997 Oct;18(10):699-703. Unique Identifier : AIDSLINE MED/98011549; McCarthy GM; MacDonald JK; School of Dentistry, Faculty of Medicine and Dentistry, University of; Western Ontario, London, Canada.; OBJECTIVES: To investigate the infection control practices of general dentists in Ontario in 1994. DESIGN: Confidential coded questionnaires were mailed to all general dental practitioners in Ontario (n = 5,176), with three follow-up attempts. Data were analyzed using Pearson s chi-squared test and multiple logistic r
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas [see comments]: J Exp Med. 1997 Dec 1;186(11):1819-29. Unique Identifier : AIDSLINE MED/98044247; Sousa CR; Hieny S; Scharton-Kersten T; Jankovic D; Charest H; Germain RN; Sher A; Lymphocyte Biology Section, Laboratory of Immunology, National; Institute of Allergy and Infectious Diseases, National Institutes of; Health, Bethesda, Maryland 20892-1892, USA. caetano@nih.gov; The early induction of interleukin (IL)-12 is a critical event in determining the development of both innate resistance and adaptive immunity to many intracellular pathogens. Previous in vitro studies have suggested that the macrophage (MPhi) is a major source of the initial IL-12 produced upon microbial stimulation a
Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV CD26)-mediated cleavage.: J Exp Med. 1997 Dec 1;186(11):1865-72. Unique Identifier : AIDSLINE MED/98044251; Oravecz T; Pall M; Roderiquez G; Gorrell MD; Ditto M; Nguyen NY; Boykins R; Unsworth E; Norcross MA; Division of Hematologic Products, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.; tamas@helix.nih.gov; CD26 is a leukocyte activation marker that possesses dipeptidyl peptidase IV activity but whose natural substrates and immunological functions have not been clearly defined. Several chemo-kines, including RANTES (regulated on activation, normal T cell expressed and secreted), have now been shown to be substrates for r
Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses.: J Virol. 1997 Dec;71(12):8999-9007. Unique Identifier : AIDSLINE MED/98037607; Rucker J; Edinger AL; Sharron M; Samson M; Lee B; Berson JF; Yi Y; Margulies B; Collman RG; Doranz BJ; Parmentier M; Doms RW; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; Human immunodeficiency virus type 1 (HIV-1) requires both CD4 and a coreceptor to infect cells. Macrophage-tropic (M-tropic) HIV-1 strains utilize the chemokine receptor CCR5 in conjunction with CD4 to infect cells, while T-cell-tropic (T-tropic) strains generally utilize CXCR4 as a coreceptor. Some viruses can use bo
The roles of the human immunodeficiency virus type 1 Pol protein and the primer binding site in the placement of primer tRNA(3Lys) onto viral genomic RNA.: J Virol. 1997 Dec;71(12):9075-86. Unique Identifier : AIDSLINE MED/98037615; Liang C; Rong L; Morin N; Cherry E; Huang Y; Kleiman L; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute-Jewish General; Hospital, Montreal, Quebec, Canada.; Factors that modulate the placement of primer tRNA(3Lys) onto the viral RNA genome in human immunodeficiency virus type 1 (HIV-1) were investigated through analysis of reverse-transcribed products that are extended from the tRNA(3Lys) primer. Mutations were introduced into the HIV-1 pol gene to result in the appearanc
Astrocyte-specific expression of human T-cell lymphotropic virus type 1 (HTLV-1) Tax: induction of tumor necrosis factor alpha and susceptibility to lysis by CD8+ HTLV-1-specific cytotoxic T cells.: J Virol. 1997 Dec;71(12):9143-9. Unique Identifier : AIDSLINE MED/98037622; Mendez E; Kawanishi T; Clemens K; Siomi H; Soldan SS; Calabresi P; Brady J; Jacobson S; Neuroimmunology Branch, National Institute of Neurologic Diseases and; Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.; Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with a chronic neurological disease termed HTLV-1-associated myelopathy/tropical spastic paraperesis (HAM/TSP). Although the pathogenesis of this disease remains to be elucidated, the evidence suggests that immunopathological mechanisms are involved. Since
Rous sarcoma virus direct repeat cis elements exert effects at several points in the virus life cycle.: J Virol. 1997 Dec;71(12):9150-6. Unique Identifier : AIDSLINE MED/98037623; Simpson SB; Zhang L; Craven RC; Stoltzfus CM; Department of Microbiology, University of Iowa, Iowa City 52242, USA.; Two approximately 135-nucleotide (nt) direct repeats flank the Rous sarcoma virus (RSV) oncogene src and are composed of two smaller repeats, dr1 (approximately 100 nt) and dr2 approximately 36 nt). These sequences have been reported to contain cis-acting signals necessary for RNA packaging and elements that allow cyt
The V3-directed immune response in natural human immunodeficiency virus type 1 infection is predominantly directed against a variable, discontinuous epitope presented by the gp120 V3 domain.: J Virol. 1997 Dec;71(12):9198-205. Unique Identifier : AIDSLINE MED/98037629; Schreiber M; Wachsmuth C; Muller H; Odemuyiwa S; Schmitz H; Meyer S; Meyer B; Schneider-Mergener J; Medical Microbiology Section, Bernhard Nocht Institute for Tropical; Medicine, Hamburg, Germany. mschreib@sgi1.chemie.uni-hamburg.de; The specific binding of antibodies to the V3 loop in sera from human immunodeficiency type 1 (HIV-1)-infected individuals was investigated. Different V3 structures were analyzed as full-length loops or by pepscan. Our data show that on full-length V3 loops, both variable regions on either side of the tip of the loop (
Discontinuous plus-strand DNA synthesis in human immunodeficiency virus type 1-infected cells and in a partially reconstituted cell-free system.: J Virol. 1997 Dec;71(12):9259-69. Unique Identifier : AIDSLINE MED/98037635; Klarmann GJ; Yu H; Chen X; Dougherty JP; Preston BD; Department of Biochemistry, Eccles Institute of Human Genetics and the; Huntsman Cancer Institute, University of Utah, Salt Lake City; 84112-5330, USA.; Human immunodeficiency virus type 1 (HIV-1) replication requires conversion of viral RNA to double-stranded DNA. To better understand the molecular mechanisms of this process, we examined viral DNA synthesis in a simple cell-free system that uses the activities of HIV-1 reverse transcriptase to convert regions of sing
Distinct functions and requirements for the Cys-His boxes of the human immunodeficiency virus type 1 nucleocapsid protein during RNA encapsidation and replication.: J Virol. 1997 Dec;71(12):9295-305. Unique Identifier : AIDSLINE MED/98037639; Schwartz MD; Fiore D; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin; Medical School, Madison 53706, USA.; The process of retroviral RNA encapsidation involves interaction between trans-acting viral proteins and cis-acting RNA elements. The encapsidation signal on human immunodeficiency virus type 1 HIV-1) RNA is a multipartite structure composed of functional stem-loop structures. The nucleocapsid (NC) domain of the Gag p
Human immunodeficiency virus type 1 Vif protein binds to the Pr55Gag precursor.: J Virol. 1997 Dec;71(12):9358-65. Unique Identifier : AIDSLINE MED/98037646; Bouyac M; Courcoul M; Bertoia G; Baudat Y; Gabuzda D; Blanc D; Chazal N; Boulanger P; Sire J; Vigne R; Spire B; INSERM U372, Marseille, France.; The Vif protein of human immunodeficiency virus type 1 is required for productive replication in peripheral blood lymphocytes. Previous reports suggest that vif-deleted viruses are limited in replication because of a defect in the late steps of the virus life cycle. One of the remaining questions is to determine wheth
Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF.: J Virol. 1997 Dec;71(12):9375-82. Unique Identifier : AIDSLINE MED/98037648; Romerio F; Gabriel MN; Margolis DM; Institute of Human Virology, Medical Biotechnology Center, University; of Maryland Biotechnology Institute, Baltimore 21201, USA.; A subpopulation of stably infected CD4+ cells capable of producing virus upon stimulation has been identified in human immunodeficiency virus (HIV)-positive individuals (T.-W. Chun, D. Finzi, J. Margolick, K. Chadwick, D. Schwartz, and R. F. Siliciano, Nat. Med. 1:1284-1290, 1995). Few host factors that directly limit
Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus.: J Virol. 1997 Dec;71(12):9392-9. Unique Identifier : AIDSLINE MED/98037650; Moraleda G; Saputelli J; Aldrich CE; Averett D; Condreay L; Mason WS; Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.; The template for synthesis of hepadnaviral RNAs is a covalently closed circular (ccc) DNA located in the nucleus of the infected hepatocyte. Hepatocytes are normally long-lived and nondividing, and antiviral therapies in chronically infected individuals face the problem of eliminating not only the replicative forms of
Identification of the V1 region as a linear neutralizing epitope of the simian immunodeficiency virus SIVmac envelope glycoprotein.: J Virol. 1997 Dec;71(12):9475-81. Unique Identifier : AIDSLINE MED/98037660; Jurkiewicz E; Hunsmann G; Schaffner J; Nisslein T; Luke W; Petry H; Department of Virology and Immunology, German Primate Centre,; Gottingen.; The sequence variability of viral structure polypeptides has been associated with immune escape mechanisms. The V1 region of simian immunodeficiency virus (SIV) is a highly variable region of the SIVmac env gene. Here, we describe the V1 region as a linear neutralizing epitope. V1 region-specific neutralizing antibodi
The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection.: J Virol. 1997 Dec;71(12):9508-14. Unique Identifier : AIDSLINE MED/98037664; Lifson JD; Nowak MA; Goldstein S; Rossio JL; Kinter A; Vasquez G; Wiltrout TA; Brown C; Schneider D; Wahl L; Lloyd AL; Williams J; Elkins WR; Fauci AS; Hirsch VM; AIDS Vaccine Program, SAIC Frederick, National Cancer; Institute-Frederick Cancer Research and Development Center, Maryland; 21702, USA. lifson@avpvx1.ncifcrf.gov; Different patterns of viral replication correlate with the natural history of disease progression in humans and macaques infected with human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), respectively. However, the viral and host factors influencing these patterns of viral replication i
Infectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinase.: J Virol. 1997 Dec;71(12):9524-30. Unique Identifier : AIDSLINE MED/98037666; Luo T; Livingston RA; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38105, USA.; Nef proteins from human immunodeficiency virus type 1 isolate SF2 HIV-1SF2) and simian immunodeficiency virus isolate mac239 SIVmac239) have been found to associate with a cellular serine/threonine kinase designated NAK. We have recently shown that the association of Nef with NAK is isolate dependent. To identify the
Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus.: J Virol. 1997 Dec;71(12):9531-7. Unique Identifier : AIDSLINE MED/98037667; Luo W; Peterlin BM; Department of Medicine, Microbiology and Immunology, Howard Hughes; Medical Institute, University of California at San Francisco,; 94143-0703, USA.; The Nef from a highly virulent strain of simian immunodeficiency virus (SIV), SIVpbj14, and a Nef from the traditional strain SIVmac239 bearing the mutation from RQ to YE (YE-Nef) both induce an acute lethal disease in monkeys. The YE mutation and its surrounding sequence resemble the immunoreceptor tyrosine-based act
Novel and dynamic evolution of equine infectious anemia virus genomic quasispecies associated with sequential disease cycles in an experimentally infected pony.: J Virol. 1997 Dec;71(12):9627-39. Unique Identifier : AIDSLINE MED/98037678; Leroux C; Issel CJ; Montelaro RC; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.; We have investigated the genetic evolution of three functionally distinct regions of the equine infectious anemia virus (EIAV) genome (env, rev, and long terminal repeat) during recurring febrile episodes in a pony experimentally infected with a well-characterized reference biological clone designated EIAV(PV). Viral
Enhancement of feline immunodeficiency virus (FIV) infection after DNA vaccination with the FIV envelope.: J Virol. 1997 Dec;71(12):9640-9. Unique Identifier : AIDSLINE MED/98037679; Richardson J; Moraillon A; Baud S; Cuisinier AM; Sonigo P; Pancino G; Genetique des Virus et Immunopharmacologie Moleculaire, ICGM-CNRS; UPR415, Institut Cochin de Genetique Moleculaire, Paris, France.; Despite intensive experimentation to develop effective and safe vaccines against the human immunodeficiency viruses and other pathogenic lentiviruses, it remains unclear whether an immune response that does not afford protection may, on the contrary, produce adverse effects. In the present study, the effect of genetic
Direct demonstration of retroviral recombination in a rhesus monkey.: J Virol. 1997 Dec;71(12):9650-3. Unique Identifier : AIDSLINE MED/98037680; Wooley DP; Smith RA; Czajak S; Desrosiers RC; Department of Microbiology and Immunology, Wright State University; School of Medicine, Dayton, Ohio 45435, USA.; Recombination may be an important mechanism for increasing variation in retroviral populations. Retroviral recombination has been demonstrated in tissue culture systems by artificially creating doubly infected cells. Evidence for retroviral recombination in vivo is indirect and is based principally on the identificati
Promonocytic U937 subclones expressing CD4 and CXCR4 are resistant to infection with and cell-to-cell fusion by T-cell-tropic human immunodeficiency virus type 1.: J Virol. 1997 Dec;71(12):9664-71. Unique Identifier : AIDSLINE MED/98037682; Moriuchi H; Moriuchi M; Arthos J; Hoxie J; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-1576, USA.; Different strains of human immunodeficiency virus type 1 (HIV-1) vary markedly in the ability to infect cells of the monocyte/macrophage (M/M) lineage. M/M are generally resistant to infection with T-cell-tropic (T-tropic) strains of HIV-1. Recently, the chemokine receptors CCR5 and CXCR4 were identified as cofactors
Efficient expression by an alphavirus replicon of a functional ribozyme targeted to human immunodeficiency virus type 1.: J Virol. 1997 Dec;71(12):9713-21. Unique Identifier : AIDSLINE MED/98037688; Smith SM; Maldarelli F; Jeang KT; Laboratory of Molecular Microbiology, National Institute of Allergy; and Infectious Diseases, Bethesda, Maryland 20892-0460, USA.; Intracellular applications of ribozymes have been limited partly by the availability of suitable high-expression systems. For RNA effectors, consideration of an RNA virus vector system for delivery and expression is reasonable. We show that alphavirus replicons can be highly efficient nonintegrating ribozyme-expressin
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein.: J Virol. 1997 Dec;71(12):9722-31. Unique Identifier : AIDSLINE MED/98037689; Wyatt R; Desjardin E; Olshevsky U; Nixon C; Binley J; Olshevsky V; Sodroski J; Dana-Farber Cancer Institute, and Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115, USA.; The human immunodeficiency virus type 1 (HIV-1) gp120 exterior envelope glycoprotein interacts with the viral receptor (CD4) and with the gp41 transmembrane envelope glycoprotein. To study the interaction of the gp120 and gp41 envelope glycoproteins, we compared the abilities of anti-gp120 monoclonal antibodies to bin
Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.: J Virol. 1997 Dec;71(12):9732-42. Unique Identifier : AIDSLINE MED/98037690; Withers-Ward ES; Jowett JB; Stewart SA; Xie YM; Garfinkel A; Shibagaki Y; Chow SA; Shah N; Hanaoka F; Sawitz DG; Armstrong RW; Souza LM; Chen IS; Department of Microbiology and Immunology, UCLA School of Medicine,; Los Angeles, California 90095-1678, USA.; The human immunodeficiency virus type 1 (HIV-1) vpr gene is an evolutionarily conserved gene among the primate lentiviruses HIV-1, HIV-2, and simian immunodeficiency viruses. One of the unique functions attributed to the vpr gene product is the arrest of cells in the G2 phase of the cell cycle. Here we demonstrate tha
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.: J Virol. 1997 Dec;71(12):9753-63. Unique Identifier : AIDSLINE MED/98037692; Kolesnitchenko V; King L; Riva A; Tani Y; Korsmeyer SJ; Cohen DI; Division of Basic Sciences, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.; We have investigated the relative contribution of apoptosis or programmed cell death (PCD) to cell killing during acute infection with T-cell-tropic, cytopathic human immunodeficiency virus type 1 (HIV-1), by employing diverse strategies to inhibit PCD or to detect its common end-stage sequelae. When Bcl-2-transfected
A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.: J Virol. 1997 Dec;71(12):9764-9. Unique Identifier : AIDSLINE MED/98037693; Desrosiers RC; Sasseville VG; Czajak SC; Zhang X; Mansfield KG; Kaur A; Johnson RP; Lackner AA; Jung JU; New England Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9102, USA.; A herpesvirus that is related to but distinct from the Kaposi s sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) was isolated from rhesus monkeys. The sequence of 10.6 kbp from virion DNA revealed the presence of an interleukin-6 homolog similar to what is present in KSHV and a closer relatedness of the D
Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.: J Virol. 1997 Dec;71(12):9808-12. Unique Identifier : AIDSLINE MED/98037702; Cao J; Sullivan N; Desjardin E; Parolin C; Robinson J; Wyatt R; Sodroski J; Dana-Farber Cancer Institute, and Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115, USA.; A human immunodeficiency virus type 1 (HIV-1) mutant lacking the V1 and V2 variable loops in the gp120 exterior envelope glycoprotein replicated in Jurkat lymphocytes with only modest delays compared with the wild-type virus. Revertants that replicated with wild-type efficiency rapidly emerged and contained only a few
Reduced viral load and lack of CD4 depletion in SCID-hu mice infected with Rev-independent clones of human immunodeficiency virus type 1.: J Virol. 1997 Dec;71(12):9817-22. Unique Identifier : AIDSLINE MED/98037704; Valentin A; Aldrovandi G; Zolotukhin AS; Cole SW; Zack JA; Pavlakis GN; Felber BK; ABL-Basic Research Program, National Cancer Institute-Frederick Cancer; Research and Development Center, Frederick, Maryland 21702-1201, USA.; The posttranscriptional control element CTE of the simian type D retrovirus has been shown to support replication of Rev-Rev-responsive-element (RRE)-deficient molecular clones of human immunodeficiency virus type 1 (HIV-1). Upon infection of peripheral blood mononuclear cells in vitro, these CTE-containing Rev-indepe
Kaposi's sarcoma associated herpesvirus deoxyribonucleic acid sequences: lack of detection in prostatic tissue of human immunodeficiency virus-negative immunocompetent adults.: J Urol. 1998 Jan;159(1):146-8. Unique Identifier : AIDSLINE MED/98063105; Rubin MA; Parry JP; Singh B; Department of Pathology, College of Physicians and Surgeons of; Columbia University, New York, New York, USA.; PURPOSE: A recent study argued that Kaposi s sarcoma associated herpesvirus is ubiquitous, as reflected by the frequent detection of its deoxyribonucleic acid (DNA) sequences in the prostatic tissue of healthy Italian men. Because these findings are discordant with serological data, our objective was to reassess the p
Randomised, controlled, community-level HIV-prevention intervention for sexual-risk behaviour among homosexual men in US cities. Community HIV Prevention Research Collaborative.: Lancet. 1997 Nov 22;350(9090):1500-5. Unique Identifier : AIDSLINE MED/98049751; Kelly JA; Murphy DA; Sikkema KJ; McAuliffe TL; Roffman RA; Solomon LJ; Winett RA; Kalichman SC; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee 53226, USA.; BACKGROUND: Community-level interventions may be helpful in population-focused HIV prevention. If members of populations at risk of HIV infection who are popular with other members can be engaged to advocate the benefits of behaviour change to peers, decreases in risk behaviour may be possible. We assessed a community
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1546. Unique Identifier : AIDSLINE MED/98049767; Aaby P; Babiker A; Darbyshire J; Nunn A; Barreto S; Alonso P; Badaro R; Barros F; Victoria C; Binka F; Biryahwaho B; Byabamazima C; Sempala S; Tugume B; Kalebu P; Kengeya-Kayondo J; Whitworth J; Paxton L; Convit J; Corrah T; McAdam K; Datta M; Dowlati Y; Fine P; Tanner M; et al
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1546-7. Unique Identifier : AIDSLINE MED/98049768; DeCock K; Shaffer N; Wiktor S; Simonds RJ; Rogers M
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1547. Unique Identifier : AIDSLINE MED/98049770; Cooper PA
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1547. Unique Identifier : AIDSLINE MED/98049769; Semba RD
Ethics of HIV trials [letter]: Lancet. 1997 Nov 22;350(9090):1547. Unique Identifier : AIDSLINE MED/98049771; Vaughan W
HIV serophobia in the mortuary: an algorithm system for handling high-risk forensic cases.: Med Sci Law. 1997 Oct;37(4):296-302. Unique Identifier : AIDSLINE MED/98045238; Patel F; UMDS Guy's Hospital, University of London.; A serophobia of the human immunodeficiency virus type 1 (HIV-1) is very noticeable in mortuaries handling high-risk cases. The morbid anxiety about occupationally acquired HIV infection in the forensic practice has made mortuary workers unduly overcautious. Despite the availability of codes of practice and informed pr
Drugs for HIV infection.: Med Lett Drugs Ther. 1997 Dec 12;39(1015):111-6. Unique Identifier : AIDSLINE MED/98066632
Pityrosporum yeasts--what's new?: Mycoses. 1997;40 Suppl 1:29-32. Unique Identifier : AIDSLINE MED/98037226; Faergemann J; Department of Dermatology, Sahlgrenska University Hospital, Goteborg,; Schweden.; The lipophilic yeast Pityrosporum ovale is a member of the normal human cutaneous flora in adults but also associated with several skin diseases. In pityriasis versicolor, under the influence of predisposing factors, P. ovale changes from the round blastospore form to the mycelial form. A great problem in pityriasis v
[High-dose therapy with fluconazole > or = 800 mg/day. Review]: Mycoses. 1997;40 Suppl 1:33-42. Unique Identifier : AIDSLINE MED/98037227; Penk A; Pittrow L; Pfizer GmbH, Abt. Medizin, Karlsruhe, BR Deutschland.; The clinical use of fluconazole in dosages > or = 800 mg/day has been reported in about 900 patients against candidemia, oropharyngeal candidiasis and cryptococcal meningitis in HIV-infected patients as well as for initial therapy of endemic mycoses. Especially in patients with life-threatening infections caused by Ca
[Fluconazole-resistant Candida species from HIV infected patients with recurrent Candida stomatitis: cross resistance to itraconazole and ketoconazole]: Mycoses. 1997;40 Suppl 1:56-63. Unique Identifier : AIDSLINE MED/98037231; Metzger S; Hofmann H; Klinik und Poliklinik fur Dermatologie und Allergologie am; Biederstein, Technische Universitat Munchen, BR Deutschland.; In vitro susceptibility to fluconazole of Candida species isolated from 83 HIV-infected patients treated with fluconazole because of recurrent Candida stomatitis was monitored over a period of two years. A microdilution assay with high-resolution antifungal assay (HR) medium and RPMI 1640-medium were compared. In vitr
[Patterns of Candida esophagitis in cancer and AIDS patients: histopathological study of 23 patients]: Mycoses. 1997;40 Suppl 1:81-5. Unique Identifier : AIDSLINE MED/98037235; Gornig M; Emmert-Buck M; Walsh TJ; Klinik fur Hautkrankheiten, Friedrich-Schiller-Universitat, Jena.; Candida oesophagitis is a common concomitant disease in neutropenic cancer patients after chemotherapie as well as in HIV-patients. In order to characterize the features of oesophagitis in each population, we reviewed the medical history and pathology records of 23 patients (18 cancer-patients, 5 HIV-patients) with cu
Molecular epidemiology of bartonella infections in patients with bacillary angiomatosis-peliosis [see comments]: N Engl J Med. 1997 Dec 25;337(26):1876-83. Unique Identifier : AIDSLINE MED/98057268; Koehler JE; Sanchez MA; Garrido CS; Whitfeld MJ; Chen FM; Berger TG; Rodriguez-Barradas MC; LeBoit PE; Tappero JW; Department of Medicine, University of California, San Francisco; 94143-0654, USA.; BACKGROUND: Bacillary angiomatosis and bacillary peliosis are vascular proliferative manifestations of infection with species of the genus bartonella that occur predominantly in patients infected with the human immunodeficiency virus. Two species, B. henselae and B. quintana, have been associated with
Vaginitis.: N Engl J Med. 1997 Dec 25;337(26):1896-903. Unique Identifier : AIDSLINE MED/98057272; Sobel JD; Department of Internal Medicine, Wayne State University School of; Medicine and Detroit Medical Center, MI, USA.
Of cats, humans, and Bartonella [editorial; comment]: N Engl J Med. 1997 Dec 25;337(26):1916-7. Unique Identifier : AIDSLINE MED/98057275; Tompkins LS
[Cytomegalovirus pneumonia in patients with AIDS treated foscarnet. Our experience]: Minerva Med. 1997 Oct;88(10):411-3. Unique Identifier : AIDSLINE MED/98059226; Terra L; Pellicano S; Calzone R; Mandica D; Milano M; Ospedale S. Giovanni di Dio, Divisione Malattie Infettive, A.S.L. n. 5; Crotone (Regione Calabria).; A case of cytomegalovirus pneumonia occurring in a patient affected with AIDS is reported. The treatment of this disease is still difficult and remission of CHV-pneumonia after therapy with foscarnet is emphasized.
Nematode infection induces Th2 cell-associated immune responses in LEC mutant rats with helper T cell immunodeficiency.: Parasite Immunol. 1997 Oct;19(10):461-8. Unique Identifier : AIDSLINE MED/98039783; Uchikawa R; Matsuda S; Yamada M; Nishida M; Agui T; Arizono N; Department of Medical Zoology, Kyoto Prefectural University of; Medicine, Japan.; Long-Evans Cinnamon (LEC) rats have maturational arrest of CD4+8- T cells from CD4+8+ cells in the thymus. Despite this, CD4+8- T cells are always present in peripheral lymphoid organs of LEC rats, suggesting that these CD4+8- T cells are generated by an uncommon pathway. We investigated the role of LEC rat peripheral
[At the National Academy of Medicine. Desire for pregnancy in the couples with a HIV-seronegative woman and a seropositive partner. A report presented by R. Henrion]: Presse Med. 1997 Oct 4;26(29):1390-1. Unique Identifier : AIDSLINE MED/98068160
[Importance of the use of health protective measures for the prevention of hepatitis B, hepatitis C and HIV infections]: Prof Inferm. 1997 Jan-Mar;50(1):35-6. Unique Identifier : AIDSLINE MED/97391721; Crispo R; Varano A
Human immunodeficiency virus infection and hepatitis: biosafety in radiology.: Radiology. 1997 Dec;205(3):619-28. Unique Identifier : AIDSLINE MED/98055230; Wall SD; Howe JM; Sawhney R; Department of Radiology, University of California-San Francisco, USA.; Radiologists frequently perform invasive diagnostic and therapeutic procedures involving needles and/or vascular access, and often they do so in darkened rooms. Therefore, they are at risk of exposure to blood-borne pathogens. The risk of HIV infection with a single sharp injury is low (0.3%), and on average 99.7% of
[Heart pathology of extracardiac origin (I). Cardiac involvement in AIDS]: Rev Esp Cardiol. 1997 Oct;50(10):721-8. Unique Identifier : AIDSLINE MED/98024831; Guillamon Toran L; Romeu Fontanillas J; Forcada Sainz JM; Curos Abadal A; Larrousse Perez E; Valle Tudela V; Servicio de Cardiologia, Hospital Universitari Germans Trias i Pujol,; Badalona, Barcelona.; A great variety of cardiac disorders have been reported in HIV-infected patients: pericarditis, myocarditis, cardiomyopathies, endocarditis, cardiac involvement through malignancies, pulmonary hypertension, arrhythmias and thromboembolic disease. In general, these disorders are asymptomatic and often diagnosed in echo
Linomide enhances apoptosis in CD4+CD8+ thymocytes.: Scand J Immunol. 1997 Nov;46(5):488-94. Unique Identifier : AIDSLINE MED/98055369; Harring AC; Xu Z; Andersson G; Hedlund G; Pharmacia & Upjohn, Lund Research Center, Sweden.; Linomide, a quinoline-3-carboxamide, has a pleiotropic immune modulating capacity and inhibits development as well as progression of disease in animal models of autoimmunity. Linomide treatment of mice resulted in a dramatic, dose-dependent decrease of the thymic cell number shortly after the start of administration.
Interferon-gamma production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major.: Scand J Immunol. 1997 Nov;46(5):495-9. Unique Identifier : AIDSLINE MED/98055370; Kemp K; Hviid L; Kharazmi A; Kemp M; Centre for Medical Parasitology at RHIMA Centre, Copenhagen University; Hospital, Rigshospitalet, Denmark.; Acquired resistance to both mycobacteria and Leishmania is primarily mediated by interferon-gamma (IFN-gamma), which triggers mechanisms leading to the death of the microorganism in macrophages. In this study, cell activation and IFN-gamma production was investigated in human peripheral blood mononuclear cells (PBMC)
How to diagnose chronic rejection. A study in porcine intestinal allografts.: Scand J Immunol. 1997 Nov;46(5):514-9. Unique Identifier : AIDSLINE MED/98055373; Kuusanmaki P; Lauronen J; Paavonen T; Pakarinen M; Yilmaz S; Hayry P; Halttunen J; Second Department of Surgery, Helsinki University Central Hospital,; University of Helsinki, Helsinki, Finland.; Porcine small bowel allografts were followed for 18 weeks during immunosuppression with cyclosporine-A (CyA), azatioprine and prednisone. The mucosal alterations noted at the 12th week were epithelial vacuolation and loss of Goblet cells. Moderate infiltration of inflammatory cells, mainly lymphocytes, was found in th
T-cell receptor BJ gene segment expression in human umbilical cord blood CD4+ and CD8+ T-cell subsets.: Scand J Immunol. 1997 Nov;46(5):520-6. Unique Identifier : AIDSLINE MED/98055374; Jeddi-Tehrani M; Hodara V; Esin S; Torok C; Wigzell H; Andersson R; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.; By employing RT-PCR-based technology, followed by Southern-blot analysis, patterns of relative TRC BJ gene segment usage in human CD4+ and CD8+ umbilical cord blood T cells (UCT) from ten children were determined in relation to seven recombined TCR BV gene (sub) families (BV 3, 5S1, 6S1-3, 8, 9, 12 and 18). Normal fre
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1969-70; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072191; Parravicini C; Lauri E; Baldini L; Neri A; Poli F; Sirchia G; Moroni M; Galli M; Corbellino M
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1970-1; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072192; Masood R; Zheng T; Tupule A; Arora N; Chatlynne L; Handy M; Whitman J Jr
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1971-2; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072193; Whitby D; Boshoff C; Luppi M; Torelli G
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1972; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072194; Brousset P; Meggetto F; Attal M; Delsol G
Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma [letter]: Science. 1997 Dec 12;278(5345):1972; discussion 1972-3. Unique Identifier : AIDSLINE MED/98072195; Cottoni F; Uccini S
Persistent long-term changes in lymphocyte subsets induced by polyclonal antibodies.: Transplantation. 1997 Nov 27;64(10):1432-7. Unique Identifier : AIDSLINE MED/98052200; Muller TF; Grebe SO; Neumann MC; Heymanns J; Radsak K; Sprenger H; Lange H; Department of Nephrology, Philipps-University of Marburg, Germany.; BACKGROUND: Clinicians are well aware of the short-term effects of immunosuppression by mono- or polyclonal antibodies. Little is known about long-term changes induced by these therapies. METHODS: Forty-three renal allograft recipients were selected according to their initial postoperative immunosuppression: (1) BI gr
PGE2 regulation of B lymphocytes and T helper 1 and T helper 2 cells: induction of inflammatory versus allergic responses.: Adv Exp Med Biol. 1997;407:237-42. Unique Identifier : AIDSLINE MED/97463174; Fedyk ER; Brown DM; Phipps RP; Immunology Program, University of Rochester School of Medicine and; Dentistry, New York 14642, USA.
Murine AIDS cured by low dosage total body irradiation.: Adv Exp Med Biol. 1997;407:451-8. Unique Identifier : AIDSLINE MED/97463205; Shen RN; Lu L; Kaiser HE; Broxmeyer HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202-5121, USA.
The therapeutic effect of Naturin-2 on Lewis lung carcinoma and murine-AIDS.: Adv Exp Med Biol. 1997;407:541-9. Unique Identifier : AIDSLINE MED/97463221; Shen RN; Lu L; Jia XQ; Wong ML; Kaiser HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202-5121, USA.
Adolescent AIDS prevention in context: the impact of peer educator qualities and classroom environments on intervention efficacy.: Am J Community Psychol. 1997 Jun;25(3):289-323. Unique Identifier : AIDSLINE MED/97474123; Ozer EJ; Weinstein RS; Maslach C; Siegel D; Psychology Dept., University of California-Berkeley 94720-1650, USA.; emilyjun@socrates.berkeley.edu; Peer-led, school-based interventions show promise for preventing AIDS among adolescents, but little is known about the processes underlying effective peer education or the conditions that promote its efficacy. This study examined the implementation in one school of an effective, peer-led AIDS prevention program for in
Illness-related support and negative network interactions: effects on HIV-infected men's depressive symptomatology.: Am J Community Psychol. 1997 Jun;25(3):395-420. Unique Identifier : AIDSLINE MED/97474126; Siegel K; Raveis VH; Karus D; Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.; Data collected as part of a psychosocial study of gay and bisexual men s experiences of living with HIV infection as a chronic illness were examined to investigate the psychological impact of the perceived availability of illness-related support and negative illness-related network interactions in a sample of men from
Idiopathic colonic inflammation in AIDS: an open trial of prednisone.: Am J Gastroenterol. 1997 Dec;92(12):2237-40. Unique Identifier : AIDSLINE MED/98060682; Gopal DV; Hassaram S; Marcon NE; Kandel G; Department of Pathology, Wellesley Hospital and University of Toronto,; Ontario, Canada.; OBJECTIVES: Idiopathic colonic inflammation and ulceration have been described in HIV infection, but only as isolated case reports. We have been treating this condition with a uniform corticosteroid protocol and now report our results. METHODS: We describe the cases of eight patients with HIV infection who had diarrhe
Thalidomide for AIDS diarrhea?: Am J Gastroenterol. 1997 Dec;92(12):2312-3. Unique Identifier : AIDSLINE MED/98060704; Surawicz CM; University of Washington, Seattle, USA.
Detection of BCL-6 rearrangements and p53 mutations in Malt-lymphomas.: Am J Hematol. 1997 Dec;56(4):206-13. Unique Identifier : AIDSLINE MED/98055558; Gaidano G; Volpe G; Pastore C; Chiarle R; Capello D; Gloghini A; Perissinotto E; Savinelli F; Bosco M; Mazza U; Pileri S; Palestro G; Carbone A; Saglio G; Dipartimento di Scienze Mediche, Universita di Torino, Novara, Italy.; gaidano@med.no.unipmn.it; Twenty-seven lymphomas of mucosa-associated lymphoid tissue MALT) derived from distinct anatomical sites were tested for the presence of genetic lesions commonly involved in B-cell lymphomagenesis, including activation of proto-oncogenes (BCL-1, BCL-2, BCL-6, and c-MYC), disruption of tumor suppressor loci p53, 6q), a
Parvovirus B19 quiescence during the course of human immunodeficiency virus infection in persons with hemophilia.: Am J Hematol. 1997 Dec;56(4):248-51. Unique Identifier : AIDSLINE MED/98055565; Goedert JJ; Erdman DD; Konkle BA; Torok TJ; Lederman MM; Kleinert D; Mandalaki T; Kessler CM; Anderson LJ; Luban NL; Viral Epidemiology Branch, National Cancer Institute, Rockville,; Maryland, USA. jg8s@nih.gov; To detect and characterize parvovirus B19 infection during the course of progressive immune deficiency from human immunodeficiency virus (HIV), ten subjects enrolled in the Multicenter Hemophilia Cohort Study were followed for 6.4 to 15 years from HIV seroconversion through extreme immune deficiency. Four to five sera
Oncotic pressure and edema formation in hypoalbuminemic HIV-infected patients with proteinuria.: Am J Kidney Dis. 1997 Dec;30(6):822-8. Unique Identifier : AIDSLINE MED/98058875; Guardia JA; Ortiz-Butcher C; Bourgoignie JJ; Department of Medicine, University of Miami/Jackson Memorial Hospital,; FL 33101, USA.; Human immunodeficiency virus nephropathy (HIVN) continues to challenge nephrologic consultative services at major urban institutions. Although noted in the literature, the decreased incidence of peripheral edema in HIVN has been unexplained to date. In HIV patients, total proteins frequently are found to be elevated d
HIV & breastfeeding: a model for sensitive midwifery.: J Aust Coll Midwives. 1997 Sep;10(3):27-31. Unique Identifier : AIDSLINE MED/98045393; Comerford KM; The following article forms part of an overall submission which assisted the author in winning the 1996 Victorian Irving Buzzard Prize. It explores important present day issues of HIV and Breastfeeding and provides an overview of a developed Model designed to help the Midwife sensitively and informatively assist the H
Complement in human disease.: Immunol Today. 1997 Oct;18(10):460-3. Unique Identifier : AIDSLINE MED/98019984; Wurzner R; Dierich MP; Institut fur Hygiene, University of Innsbruck, Austria.
Th1-type immunity is incompatible with successful pregnancy.: Immunol Today. 1997 Oct;18(10):478-82. Unique Identifier : AIDSLINE MED/98019988; Raghupathy R; Dept. of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.; Raj@hscc.kuniv.edu.kw; Several years ago, the rather provocative question was raised: is successful pregnancy a T helper 2 (Th2) phenomenon? Implicit in this argument is the corollary that unsuccessful pregnancy is a Th1-type situation. Here, evidence from murine and human pregnancy is presented to show that, since Th1-type cytokines mediat
Blind T-cell homeostasis and HIV infection [letter]: Immunol Today. 1997 Oct;18(10):505-7. Unique Identifier : AIDSLINE MED/98019994; Cole S
Paternal leukocytes selectively increase secretion of IL-4 in peripheral blood during normal pregnancies: demonstrated by a novel one-way MLC measuring cytokine secretion.: Am J Reprod Immunol. 1997 Nov;38(5):320-6. Unique Identifier : AIDSLINE MED/98013277; Ekerfelt C; Matthiesen L; Berg G; Ernerudh J; Department of Neurology, University Hospital, Linkoping, Sweden.; PROBLEM: It has been proposed that immune responses in normal pregnancy are Th2-like, thereby protecting the fetus and placenta from being rejected. Some studies have shown Th2-deviated systemic responses to different antigens and mitogens. The aim of this study was to demonstrate the specific T cell cytokine response
Sequence variations between two Epstein-Barr virus LMP 1 variants have no effect on the activation of NF-kappaB activity.: DNA Cell Biol. 1997 Nov;16(11):1311-9. Unique Identifier : AIDSLINE MED/98068838; Yeh TS; Li SN; Wu CJ; Liu ST; Meng CL; Chang YS; Graduate Institute of Microbiology and Immunology, National Yang-Ming; University, Shih-pai, ROC.; Previously, we reported that the LMP 1 gene of Epstein-Barr virus EBV) derived from nasopharyngeal carcinoma (NPC) tissues (i.e., NLMP 1 gene) was able to transform BALB/c3T3 cells. On the other hand, LMP 1 gene of B95-8 strain (i.e., BLMP 1 gene) was not able to transform these cells (Chen et aL, 1992). Further studi
[Data-sets as flexible tool in nursing plans. Care of patients with HIV/AIDS benefited by clearness]: TVZ. 1997 May 3;107(9):262-5. Unique Identifier : AIDSLINE MED/98079826; van Zelm R; ten Napel H; Aids-afdeling van het AMC.
IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 mice.: Am J Respir Cell Mol Biol. 1997 Dec;17(6):733-9. Unique Identifier : AIDSLINE MED/98072218; Hoag KA; Lipscomb MF; Izzo AA; Street NE; Cancer Immunobiology Center and Department of Microbiology, University; of Texas Southwestern Medical Center, Dallas 75235-8576, USA.; A murine model was used to assess the role of cytokines in initiating protective T-cell-mediated immunity in the lung. A pulmonary infection was initiated by intratracheal inoculation of Cryptococcus neoformans (Cne). Previously, we had established that Cne lung clearance was mouse-strain-specific: C.B-17 mice were re
Spread of HIV from non-drug user to non-drug user [letter]: Br J Gen Pract. 1997 Sep;47(422):595. Unique Identifier : AIDSLINE MED/98069582; Wyld R; Robertson R; Gillon J
Use of a green fluorescent protein as a marker for human immunodeficiency virus type 1 infection.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1077-81. Unique Identifier : AIDSLINE MED/97426107; Page KA; Liegler T; Feinberg MB; Gladstone Institute of Virology and Immunology and the Department of; Microbiology and Immunology, University of California, San Francisco; 94141, USA.; We constructed a recombinant human immunodeficiency virus type 1 HIV-1) provirus called R7-GFP that expresses a modified form of a green fluorescent protein (GFP) from the jellyfish Aequorea victoria by substituting GFP-coding sequences for Nef-coding sequences. Alanine was substituted for serine at amino acid positio
Didanosine but not high doses of hydroxyurea rescue pigtail macaque from a lethal dose of SIV(smmpbj14).: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1083-8. Unique Identifier : AIDSLINE MED/97426108; Lori F; Gallo RC; Malykh A; Cara A; Romano J; Markham P; Franchini G; Basic Research Laboratory, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; It has been previously reported that hydroxyurea (HU) displays anti-HIV-1 activity and potentiates the antiviral effects of didanosine (ddI) in vitro. To assess the antiviral efficacy of HU in an animal model, the effects of HU and ddI, either individually or as combinatio
Decrease in phosphocreatine level in skeletal muscle of SIV-infected rhesus macaques correlates with decrease in intracellular glutathione.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1089-91. Unique Identifier : AIDSLINE MED/97426109; Hack V; Gross A; Bohme A; Stahl-Hennig C; Droge W; Department of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Loss of skeletal muscle tissue (cachexia) is one of the hallmarks of HIV infection. It has been found (1) that creatine kinase, i.e., an enzyme of pivotal importance in muscular mitochondrial energy metabolism, is inhibited by oxidative glutathiolation, and 2) that reduced glutathione (GSH) is decreased in skeletal mu
Antiretroviral effect of combined zidovudine and reduced glutathione therapy in murine AIDS.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1093-9. Unique Identifier : AIDSLINE MED/97426110; Magnani M; Fraternale A; Casabianca A; Schiavano GF; Chiarantini L; Palamara AT; Ciriolo MR; Rotilio G; Garaci E; Institute of Biological Chemistry Giorgio Fornaini, University of; Urbino, Italy. magnani@bib.uniurb.it; A combination of antiretroviral drugs acting at different points in the virus replication cycle was evaluated in a murine retrovirus-induced immunodeficiency model of AIDS (MAIDS). Intramuscular administration of high doses of reduced glutathione GSH, 100 mg/mouse/day) and
Structural and functional analysis of negatively charged milk proteins with anti-HIV activity.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1101-7. Unique Identifier : AIDSLINE MED/97426111; Berkhout B; Derksen GC; Back NK; Klaver B; de Kruif CG; Visser S; Department of Human Retrovirology, Academic Medical Center, University; of Amsterdam, The Netherlands. B.Berkhout@AMC.UVA.NL; Several polyanionic reagents such as dextran sulfates, heparin sulfates, and negatively charged proteins have been reported to exhibit anti-HIV activity in vitro. Particularly potent inhibition has been reported for the milk protein beta-lactoglobulin (betaLG) on modification by 3-hydroxyphthalic anhydride (3HP). The
Production and characterization of monoclonal antibodies to simian immunodeficiency virus envelope glycoproteins.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1109-19. Unique Identifier : AIDSLINE MED/97426112; Babas T; Le Grand R; Dormont D; Bahraoui E; Laboratoire d'Immunovirologie des Lentivirus des Primates, UFR SVT,; Universite Paul Sabatier, Toulouse, France.; Twelve monoclonal antibodies (MAbs), TB1 to TB12, were produced against a soluble vaccinia recombinant envelope glycoprotein gp140) from simian immunodeficiency virus SIVmac251. These MAbs recognized SIV gp140 with a relatively high affinity (K0.5 from 6.7 x 10(-8) to 4 x 10(-9) M). All the MAbs except TB9, TB11, and
Most potential linear B cell epitopes of Env glycoproteins of feline immunodeficiency virus are immunogenically silent in infected cats.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1121-9. Unique Identifier : AIDSLINE MED/97426113; Massi C; Lombardi S; Indino E; Matteucci D; La Rosa C; Esposito F; Garzelli C; Bendinelli M; Retrovirus Center, Department of Biomedicine, University of Pisa,; Italy.; A battery of sixty-six 20- to 23-amino acid synthetic peptides, partially overlapping by 10-12 amino acids, spanning the entire sequence of the envelope (Env) glycoproteins of the Petaluma isolate of feline immunodeficiency virus (FIV-Pet), has been used to map Env linear B cell epitopes. By screening FIV-infected cat
Cortical cell loss in asymptomatic cats experimentally infected with feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1131-40. Unique Identifier : AIDSLINE MED/97426114; Meeker RB; Thiede BA; Hall C; English R; Tompkins M; Department of Neurology, University of North Carolina, Chapel Hill; 27599, USA.; Specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) were used to evaluate the development of central nervous system changes during the asymptomatic stages of viral infection. The brains of asyptomatic cats were examined at postinoculation times ranging from 8 weeks to 3 years f
High prevalence of false-negative anti-HTLV type I/II enzyme-linked immunosorbent assay results in HIV type 1-positive patients.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1141-6. Unique Identifier : AIDSLINE MED/97426115; Zehender G; De Maddalena C; Gianotto M; Cavalli B; Santambrogio S; Orso M; Moroni M; Galli M; Clinica delle Malattie Infettive, Universita di Milano, Milan, Italy.; zehender@imiucca.csi.unimi.it; A high frequency of false-negative anti-HTLV-I/II ELISA results has been reported by several authors. To verify the possible underestimate of the prevalence of HTLV-II infection in subjects infected by HIV-1, we used the PCR to investigate the presence of HTLV DNA in peripheral blood mononuclear cells (PBMCs) collecte
Detection of simian T cell leukemia virus type I infection in seronegative macaques.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1147-53. Unique Identifier : AIDSLINE MED/97426116; Liska V; Fultz PN; Su L; Ruprecht RM; Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; Simian species of Asian and African origin are naturally infected with the simian T cell leukemia virus type I (STLV-I). Like the closely related human T cell leukemia virus type I (HTLV-I), STLV-I is primarily cell associated, and typical infections exhibit low viral burdens. Four macaques experimentally inoculated w
Genetic analysis of HIV type 1 group O p24gag sequences from Cameroon and Equatorial Guinea.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1155-8. Unique Identifier : AIDSLINE MED/97426117; Hackett J Jr; Zekeng L; Brennan CA; Lund JK; Vallari AS; Hickman RK; Gurtler L; Kaptue L; Devare SG; AIDS Research and Retrovirus Discovery, Abbott Laboratories, North; Chicago, Illinois 60064, USA.
Sequence of chemokine receptor gene CCR5 in chimpanzees, a natural HIV type 1 host.: AIDS Res Hum Retroviruses. 1997 Sep 1;13(13):1159-61. Unique Identifier : AIDSLINE MED/97426118; Zacharova V; Zachar V; Goustin AS; Center for Molecular Medicine and Genetics, Wayne State University,; Detroit, Michigan 48202-3917, USA.
Dynamics of syncytium-inducing and non-syncytium-inducing type 1 human immunodeficiency viruses during primary infection.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1447-51. Unique Identifier : AIDSLINE MED/98051109; Rodrigo AG; Department of Microbiology, University of Washington, Seattle; 98195-7740, USA. rodrigo@u.washington.edu; Syncytium-inducing (SI) type 1 human immunodeficiency viruses HIV-1) replicate faster in vitro and are generally more cytopathic to T cells than non-syncytium-inducing (NSI) HIV-1. Early in infection, the virus population typically consists of NSI viruses, with SI viruses appearing later. This is true even when both S
Thy/Liv-SCID-Hu mice implanted with human intestine: an in vivo model for investigation of mucosal transmission of HIV.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1453-60. Unique Identifier : AIDSLINE MED/98051110; Gibbons C; Kollmann TR; Pettoello-Mantovani M; Kim A; Goldstein H; Department of Pediatrics, Albert Einstein College of Medicine, Bronx,; New York 10461, USA.; Mucosal transmission is a major route by which individuals become infected with HIV. Investigation into the mechanism by which mucosal transmission of HIV occurs would be greatly facilitated by the development of a small animal model infectible with HIV by the mucosal route. We have previously described a SCID-hu mous
Human immunodeficiency virus type 1 glycoprotein 120-specific T lymphocytes provide intermolecular help for anti-CD4 autoantibody production in exposed uninfected subjects.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1461-9. Unique Identifier : AIDSLINE MED/98051111; Furci L; Beretta A; Siccardi A; Lazzarin A; Confetti C; Magnani Z; Scarpellini P; Lopalco L; Burastero SE; Department of Biological and Technological Research (DIBIT), San; Raffaele Scientific Institute, Milan, Italy.; Anti-CD4 antibodies have been documented in about 10-20% of HIV-infected patients. This autoimmune response could be triggered by increased CD4 processing and unveiling of hidden cryptic) epitopes. Multiple markers of exposure to HIV have been described in exposed uninfected individuals. Here, we investigated the mech
Restricted specificity of anti-V3 antibodies induced in humans by HIV candidate vaccines.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1471-85. Unique Identifier : AIDSLINE MED/98051112; Coeffier E; Excler JL; Kieny MP; Meignier B; Moste C; Tartaglia J; Pialoux G; Salmon-Ceron D; Leclerc C; Unite de Biologie des Regulations Immunitaires, Institut Pasteur,; Paris, France.; We analyzed the fine specificity of anti-V3 antibodies elicited in three different species (human, guinea pig, and macaque) by various HIV candidate vaccines. Following immunization with recombinant canarypox virus expressing gp160MN or with recombinant gp160MN/LAI, this antibody response was shown to be directed agai
Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1487-95. Unique Identifier : AIDSLINE MED/98051113; Berglund P; Quesada-Rolander M; Putkonen P; Biberfeld G; Thorstensson R; Liljestrom P; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; Infection of macaques with chimeric simian-human immunodeficiency viruses (SHIVs) allows evaluation of HIV-1 envelope vaccines. SHIV-4 is based on SIVmac239 but carries the env, tat, and rev genes of HIV-1IIIB. In this study we used Semliki Forest virus SFV) RNA vectors to express the envelope protein gp160 of HIV-1II
Immunogenicity of recombinant vaccinia viruses that display the HIV type 1 envelope glycoprotein on the surface of infectious virions.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1497-500. Unique Identifier : AIDSLINE MED/98051114; Katz E; Moss B; Department of Virology, Hebrew University-Hadassah Medical School,; Jerusalem, Israel. katzeh@cc.huji.ac.il; A chimeric protein, consisting of the extracellular domain of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein attached to the transmembrane and cytoplasmic domains of the vaccinia virus B5R glycoprotein, is displayed on the surface of extracellular recombinant vaccinia virus particles, whereas th
Study of spontaneous apoptosis in HIV+ patients: correlation with clinical progression and T cell loss.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1501-8. Unique Identifier : AIDSLINE MED/98051115; Prati E; Gorla R; Malacarne F; Airo P; Brugnoni D; Gargiulo F; Tebaldi A; Castelli F; Carosi G; Cattaneo R; Clinical Immunology Unit, Spedali Civili, Brescia, Italy.; In vitro spontaneous apoptosis (SA) of lymphocytes was studied in HIV infection to evaluate possible clinical and prognostic correlations, in a transsectional study of 101 individuals in different clinical categories and in a prospective longitudinal study of 18 asymptomatic individuals (mean follow-up, 17.2 months).
Downregulation of HLA class I antigen expression in CD4+ T lymphocytes from HIV type 1-infected individuals.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1509-16. Unique Identifier : AIDSLINE MED/98051116; Puppo F; Brenci S; Bosco O; Lanza L; Barocci S; Nocera A; Ghio M; Contini P; Setti M; Scudeletti M; Indiveri F; Department of Internal Medicine, University of Genova, Italy.; The expression of HLA class I antigens is downregulated in CD4+ T cells following in vitro HIV-1 infection. We determined whether the expression of HLA class I antigens is downmodulated in peripheral blood lymphocytes (PBLs) of HIV-1-positive subjects and whether this defect correlates with disease progression. A coho
Inhibition of plating of human T cell leukemia virus type I and syncytium-inducing types of human immunodeficiency virus type 1 by polycations.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1517-23. Unique Identifier : AIDSLINE MED/98051117; Haraguchi Y; Takeuchi Y; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Maebashi, Japan.; We examined the effects of polycations, namely, diethylaminoethyl-dextran (DEAE-dextran) and hexadimethrine bromide (Polybrene), on infection with the retroviruses human T cell leukemia virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus type 1 (HIV-1). The plating of vesicular stomatitis virus
A synthetic peptide corresponding to the carboxy terminus of human immunodeficiency virus type 1 transmembrane glycoprotein induces alterations in the ionic permeability of Xenopus laevis oocytes.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1525-32. Unique Identifier : AIDSLINE MED/98051118; Comardelle AM; Norris CH; Plymale DR; Gatti PJ; Choi B; Fermin CD; Haislip AM; Tencza SB; Mietzner TA; Montelaro RC; Garry RF; Graduate Program in Molecular and Cellular Biology, Tulane University,; New Orleans, Louisiana 70112, USA.; The carboxy-terminal 29 amino acids of the human immunodeficiency virus type 1 transmembrane glycoprotein (HIV-1 TM) are referred to as lentivirus lytic peptide 1 (LLP-1). Synthetic peptides corresponding to LLP-1 have been shown to induce cytolysis and to alter the permeability of cultured cells to various small mole
Effects of tapering doses of oral prednisone on viral load among HIV-infected patients with unexplained weight loss.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1533-7. Unique Identifier : AIDSLINE MED/98051119; Kilby JM; Tabereaux PB; Mulanovich V; Shaw GM; Bucy RP; Saag MS; Center for AIDS Research, Department of Pathology, University of; Alabama at Birmingham School of Medicine, 35294, USA.; In an exploratory study of virologic and immunomodulatory effects of corticosteroid therapy for wasting syndrome, four HIV-infected adults with recent unexplained weight loss were given tapering doses of prednisone over a 2-month period. Serum neopterin and TNF receptor II levels decreased from baseline after 7 days.
Diversity and distribution of gag and env subtypes among 146 HIV type 1 isolates in Taiwan.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1539-43. Unique Identifier : AIDSLINE MED/98051120; Chang KS; Lin CI; Salminen MO; Liao SK; Wu AM; Lin HC; Lin RY; Twu SC; Graduate Institute of Clinical Medicine, Chang Gung Medical College,; Taoyuan-Hsien, Taiwan.
Phylogenetic analysis of a simian T lymphotropic virus type I from a hamadryas baboon.: AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1545-8. Unique Identifier : AIDSLINE MED/98051121; Liu HF; Goubau P; Van Brussel M; Desmyter J; Vandamme AM; Rega Institute for Medical Research and University Hospitals,; Katholieke Universiteit Leuven, Belgium.
Long-term treatment with recombinant interferon alpha-2b prolongs survival of asymptomatic HIV-infected individuals.: Biotherapy. 1997;10(2):107-13. Unique Identifier : AIDSLINE MED/98041066; Rivero J; Fraga M; Cancio I; Cuervo J; Lopez-Saura P; Sanatorio Santiago de las Vegas, La Habana, Cuba.; RATIONALE AND OBJECTIVE: Early long-term treatment with recombinant interferon (IFN) alpha-2b delayed disease progression in asymptomatic Human Immunodeficiency Virus (HIV) carriers in a randomized trial that lasted from October 1987 to February 1992 14). The aim of the work reported in this paper was to observe if th
Alcohol, tobacco and recreational drug use and the risk of non-Hodgkin's lymphoma.: Br J Cancer. 1997;76(11):1532-7. Unique Identifier : AIDSLINE MED/98062126; Nelson RA; Levine AM; Marks G; Bernstein L; Department of Preventive Medicine, School of Medicine, University of; Southern California, Los Angeles 90033, USA.; A population based case-control study was conducted to determine whether risk of non-Hodgkin s lymphoma (NHL) in the absence of HIV infection is related to the previous use of tobacco, alcohol or recreational drugs. A total of 378 residents of Los Angeles County who were diagnosed
Altered effector responses of H-Y transgenic CD8+ cells.: Int Immunol. 1997 Oct;9(10):1423-30. Unique Identifier : AIDSLINE MED/98013624; Arsov I; Vukmanovic S; Michael Heidelberger Division of Immunology, Department of Pathology,; NYU Medical Center, NY 10016, USA.; The primary role of CD8+ T cells is to destroy virus-infected or tumor cells expressing cognate antigens in the form of peptide-MHC class I complexes. This destruction is primarily achieved by the actions of lytic mediators and/or lymphokines. In this report, we show that mature, H-Y/Db-specific CD8+ T cells from H-Y
Control of TCR V alpha-mediated positive repertoire selection and alloreactivity by differential J alpha usage and CDR3 alpha composition.: Int Immunol. 1997 Oct;9(10):1441-52. Unique Identifier : AIDSLINE MED/98013626; Torres-Nagel N; Deutschlander A; Herrmann T; Arden B; Hunig T; Institute for Virology and Immunobiology, University of Wurzburg,; Germany.; In rats expressing the f allele of the rat MHC (RT1f), CD8 T cells utilizing the V alpha 8.2 segment are 10-fold overselected during thymic development, resulting in V alpha 8.2 expression by 14% of mature CD8 T cells as compared to 1-2% in MHC congenic strains. In the alloreactive responses of CD8 T cells from RT1f-n
Exposure of resting peripheral blood T cells to HIV-1 particles generates CD25+ killer cells in a small subset, leading to induction of apoptosis in bystander cells.: Int Immunol. 1997 Oct;9(10):1453-62. Unique Identifier : AIDSLINE MED/98013627; Kameoka M; Suzuki S; Kimura T; Fujinaga K; Auwanit W; Luftig RB; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; Apoptosis is a major mechanism whereby HIV-1 depletes uninfected CD4+ and CD8+ T cells. We previously showed that resting peripheral blood T cells derived from healthy donors were killed by an apoptotic mechanism after adsorption to gp120-containing, protease-defective HIV-1 (L-2) particles, more effectively than pare
Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression.: Int Immunol. 1997 Oct;9(10):1527-36. Unique Identifier : AIDSLINE MED/98013635; Chidgey A; Boyd R; Department of Pathology and Immunology, Monash Medical School,; Prahran, Melbourne, Australia.; Engagement of the TCR is a pivotal step in thymocyte development, ultimately resulting in the survival (positive selection) or loss negative selection) of developing T cells. The roles of peptides and stromal cell interactions necessary for these selection events, however, are still poorly understood. To investigate t
Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ.: Int Immunol. 1997 Oct;9(10):1601-5. Unique Identifier : AIDSLINE MED/98013643; Koniaras C; Bennett SR; Carbone FR; Heath WR; Lew AM; Walter and Eliza Hall Institute of Medical Research, PO Royal; Melbourne Hospital, Victoria, Australia.; The ultimate fate of T cells undergoing antigen-induced cell death in vivo remains controversial. Whereas apoptosis of CD4+ T cells driven by superantigen is readily detectable in lymphoid organs, CD8+ T cells have been reported to disappear from the lymphoid organs and accumulate in the liver where they undergo apopt
Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.: Biochemistry. 1997 Nov 25;36(47):14384-91. Unique Identifier : AIDSLINE MED/98062905; Engen JR; Smithgall TE; Gmeiner WH; Smith DL; Department of Chemistry, University of Nebraska-Lincoln 68588-0304,; USA.; Protein unfolding on a fast time scale (milliseconds-minutes) has been widely reported, but slower unfolding events (10 min-hours) have received less attention. Amide hydrogen exchange (HX) and mass spectrometry (MS) were used to investigate the unfolding dynamics of the hematopoietic cell kinase (Hck) SH3 domain. Ana
Role of glutamine-151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis.: Biochemistry. 1997 Nov 25;36(47):14430-8. Unique Identifier : AIDSLINE MED/98062910; Kaushik N; Harris D; Rege N; Modak MJ; Yadav PN; Pandey VN; Department of Biochemistry and Molecular Biology, UMD-New Jersey; Medical School, Newark 07103, USA.; Glutamine-151 of HIV-1 RT has been shown to be a catalytically important residue through the characterization of its mutant phenotype Glu151Ala (Sarafianos et al., 1995a). To further understand the role of this residue, we have extended this analysis to include polymerization on natural RNA template in addition to DNA
RNA secondary structure switching during DNA synthesis catalyzed by HIV-1 reverse transcriptase.: Biochemistry. 1997 Dec 2;36(48):14778-85. Unique Identifier : AIDSLINE MED/98066428; Suo Z; Johnson KA; Department of Biochemistry and Molecular Biology, Pennsylvania State; University, University Park 16802, USA.; Changes in RNA secondary structure have been found to play important roles in translational regulation, protein synthesis, and mRNA splicing. In studies utilizing a 66 nucleotide RNA template with a stable hairpin structure, we have examined the effects of RNA secondary structure on HIV-1 reverse transcriptase activit
Adolescent under enrollment in national clinical research: it is time to ask why [comment]: J Adolesc Health. 1997 Dec;21(6):374-5. Unique Identifier : AIDSLINE MED/98065417; Rogers AS; Adolescent, and Maternal AIDS Branch, Center for Research for Mothers; and Children, National Institute of Child Health and Human; Development, Bethesda, Maryland, USA.
Quality of life in HIV-infected women in the south-eastern United States.: AIDS Care. 1997 Oct;9(5):501-12. Unique Identifier : AIDSLINE MED/98068204; Sowell RL; Seals BF; Moneyham L; Demi A; Cohen L; Brake S; College of Nursing, University of South Carolina, Columbia 29204, USA.; The purpose of this study was to evaluate the relative importance of social (social support, material resources, disclosure, and family functioning) and psychological factors (stigma, emotional distress, intrusion, avoidance, and fatalism) as predictors of the quality of life of women infected with HIV. The cross-sect
A survey of women with HIV about their expectations for care.: AIDS Care. 1997 Oct;9(5):513-22. Unique Identifier : AIDSLINE MED/98068205; Meredith K; Delaney J; Horgan M; Fisher E Jr; Fraser V; Washington University School of Medicine, St Louis, Missouri 63110,; USA. kmeredit@imgate.wustl.edu; As an increasing number of women become infected with the human immunodeficiency virus (HIV), it is important to understand their expectations regarding the health care services they receive. In 1995 a new centre was opened at an academic centre in St Louis, Missouri, to provide comprehensive care to women with HIV. T
Trauma of discovery: women's narratives of being informed they are HIV-infected.: AIDS Care. 1997 Oct;9(5):523-38. Unique Identifier : AIDSLINE MED/98068206; Stevens PE; Tighe Doerr B; University of Wisconsin-Milwaukee School of Nursing 53201, USA.; The purposes of this research report are to describe women s subjective experiences of being informed of a positive HIV antibody test and, from their point of view, to explain the meaning and impact of discovering that one is HIV-infected. In this qualitative narrative study, a racially diverse, low-income sample of 3
Vulnerability on the streets: female sex workers and HIV risk.: AIDS Care. 1997 Oct;9(5):539-47. Unique Identifier : AIDSLINE MED/98068207; Pyett PM; Warr DJ; Centre for the Study of Sexually Transmissible Diseases, La Trobe; University, Carlton, Victoria, Australia. P.Pyett@lure.latrobe.edu.au; In-depth interviews were conducted with 24 purposively selected female sex workers who were perceived to be vulnerable to risks associated with their lifestyle and occupation. Brothel workers were found to be considerably less exposed to risk than the women working on the streets. Client resistance was the major obsta
'Appropriate' male and female safer sexual behaviour in heterosexual relationships.: AIDS Care. 1997 Oct;9(5):549-61. Unique Identifier : AIDSLINE MED/98068208; Buysse A; Van Oost P; University of Ghent, Belgium. Ann.Buysse@rug.ac.be; This paper is an attempt to explore how traditional gender role socialization runs counter to safer sexual practices. Structured interviews (N = 448 sexual encounters) were conducted with heterosexual young adults in natural settings such as summer music festivals and youth houses/youth clubs. Congruent with a persp
Concomitants of HIV/STD risk behaviours and intention to engage in risk behaviours in adolescents in India.: AIDS Care. 1997 Oct;9(5):563-75. Unique Identifier : AIDSLINE MED/98068209; Mathai R; Ross MW; Hira S; School of Public Health, University of Texas, Houston 77225, USA.; A total of 1230 year 11 and 12 anglophone college students, modal age 16 and 17, in three colleges in Mumbai (Bombay), India , were studied with regard to sexual behaviours or risk of sexual behaviours, beliefs about sex, HIV/STD knowledge, and perceived norms regarding sexual behavi
Prevention of vertical HIV transmission with zidovudine: projected impact of HIV testing and prenatal care.: AIDS Care. 1997 Oct;9(5):577-88. Unique Identifier : AIDSLINE MED/98068210; Turner BJ; McKee-Nelsen L; Fanning TR; Hauck WW; Division of General Internal Medicine, Jefferson Medical College,; Philadelphia, PA, USA.; We sought to estimate the impact of maternal HIV testing and prenatal care on the potential to reduce vertical transmission through zidovudine ( AZT ) use by HIV-infected mothers. We evaluated the prepartum maternal HIV diagnosis rate, prenatal care, di
Disclosing HIV status and sexual orientation to employers.: AIDS Care. 1997 Oct;9(5):589-99. Unique Identifier : AIDSLINE MED/98068211; Simoni JM; Mason HR; Marks G; Ferkauf Graduate School of Psychology/Yeshiva University, Albert; Einstein College of Medicine, Bronx, NY 10461-1602, USA.; jms112@columbia.edu; Seropositive gay and bisexual men who reveal their sexual orientation or HIV/AIDS status to their employer risk discriminatory reprisals. However, non-disclosure may limit potential social, emotional, and tangible support. Among our sample of 389 seropositive gay and bisexual men employed in the US, 52% were out to
Caring for patients with HIV disease: the experience of a generic hospice.: AIDS Care. 1997 Oct;9(5):601-7. Unique Identifier : AIDSLINE MED/98068212; Gibbs LM; Ellershaw JE; Williams MD; St Christopher's Hospice, London, UK.; This study describes the experience of a generic hospice admitting people with advanced HIV disease over a 4-year period. Data were collected retrospectively for all patients with HIV disease admitted. The aim of the study was to review the number of referrals, the reason for referral, subsequent symptom control and m
Parental HIV discordancy and its impact on the family.: AIDS Care. 1997 Oct;9(5):609-15. Unique Identifier : AIDSLINE MED/98068213; White J; Melvin D; Moore C; Crowley S; St Mary's Hospital, London, UK.; There is little or no available information on the effect of HIV discordancy in heterosexual relationships on different family members. A review of case notes was carried out on all families who had a child referred to the paediatric HIV service/family clinic at St Mary s Hospital between January 1991 and March 1996.
World Health Organization global AIDS statistics.: AIDS Care. 1997 Oct;9(5):625-32. Unique Identifier : AIDSLINE MED/98077168
[Analysis of the microbiological information derived from the sentinel laboratory network for the monitoring of the human immunodeficiency virus infection in Catalonia (1989-1995)]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):401-6. Unique Identifier : AIDSLINE MED/98064465; Blanch C; Vall M; Casabona J; Centre d'Estudis Epidemiologics sobre la VIH/sida a Catalunya; CEESCAT), Hospital Universitari Germans Trias i Pujol, Badalona,; Barcelona.; BACKGROUND: The epidemiologic information on AIDS derived exclusively from the AIDS case registry presents a series of limitations. To solve some of these epidemiologic surveillance systems of HIV infection have been designed. The information of the microbiology laboratories in which anti-HIV antibody detection tests
[Spanish bibliographic production on AIDS. Bibliometric approach]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):407-10. Unique Identifier : AIDSLINE MED/98064466; Osca J; Instituto de Estudios Documentales e Historicos sobre la Ciencia,; Facultad de Medicina, Universidad de Valencia, CSIC.; BACKGROUND: We analyze Spanish production of the books published in Spain about AIDS and they are put together in the database ISBN. METHODS: For every book there considered various things: author, year of publication, ISBN classification, language, edition, place publicated and pub
[Historical cohort study on bacterial pneumonias as predictors of the progression of the human immunodeficiency virus disease]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):418-21. Unique Identifier : AIDSLINE MED/98064469; Teira R; Virosta M; Munoz J; Zubero Z; Cisterna R; Santamaria JM; Seccion de Enfermedades Infecciosas, Hospital de Basurto, Bilbao.; BACKGROUND: Recognition of the importance of bacterial pneumonias in the context of HIV infection has continuously grown throughout the pandemia. It has recently been suggested that these may be predictors of progression of the disease. PATIENTS AND METHODS: The evolution of an historic cohort of patients with HIV inf
[Pulmonary condensation in a patient with AIDS]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):429-30. Unique Identifier : AIDSLINE MED/98064473; Elejalde JI; Reparaz J; Castiello J; Uriz J; Sola J; Valenti C; Servicio de Medicina Interna, Hospital de Navarra, Mendillorri,; Navarra.
[Determination of anti-HIV using an automated ELFA method (enzyme linked immunofluorescent assay)(VIDAS HIV 1/2 new) (letter)]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):439. Unique Identifier : AIDSLINE MED/98064478; Jaqueti J; Bua MC; Preciado B
[Oral and esophageal aphthous ulcers in a child with AIDS successfully treated with colony stimulating factors (GM-CSF) letter)]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):439-40. Unique Identifier : AIDSLINE MED/98064479; Pocheville I; Gutierrez C; Gonzalez J
[Streptococcal necrotising fasciitis in a hemophilic patient with the human immunodeficiency virus infection (letter)]: Enferm Infecc Microbiol Clin. 1997 Oct;15(8):443-4. Unique Identifier : AIDSLINE MED/98064483; Galan F; Barrero F; Marin P; Martorell J; Capote FJ
[The clinical and evolutional characteristics of visceral leishmaniasis in patients with HIV infection]: An Med Interna. 1997 Oct;14(10):506-10. Unique Identifier : AIDSLINE MED/98057991; Delgado Fernandez M; Garcia Ordonez MA; Martos Perez F; Reguera Iglesias JM; Jimenez Onate F; Colmenero Castillo JD; Departamento de Medicina Interna, Hospital Regional Carlos Haya,; Malaga.; OBJECTIVE: To analyze the clinical features, yield of the diagnostic techniques, and therapeutic response of HIV-associated visceral leishmaniasis (VL), and compare the initial episodes to the relapses. METHODS: Forty-one episodes of leishmaniasis visceral, diagnosed in 31 HIV-positive patients between 1st February 19
[HIV/AIDS in primary care: the opinions and needs of Galician health professionals]: Aten Primaria. 1997 Oct 15;20(6):319-23. Unique Identifier : AIDSLINE MED/98058095; Figueiras A; Lopez-Alvarez XL; Monteagudo-Romero J; Taboada-Rodriguez XA; Area de Medicina Preventiva e Saude Publica, Universidade de Santiago; de Compostela.; OBJECTIVE: To find the views and identify the needs of Galician primary health care (PHC) professionals concerning HIV/AIDS. DESIGN: An observational cross-sectional study. SETTING: Autonomous Community of Galicia. PARTICIPANTS: Primary care professionals from medicine (N = 1,523, n = 510), nursing (N = n = 220) and p
[Study of HIV isolation in sperm (letter; comment)]: Contracept Fertil Sex. 1997 Oct;25(10):802. Unique Identifier : AIDSLINE MED/98064445; Greacen T; Brechard N
[Nursing and AIDS: knowledge and paradigm]: Rev Lat Am Enfermagem. 1997 Jan;5(1):65-73. Unique Identifier : AIDSLINE MED/97391744; Xavier I de M; Leite JL; Braga GM; Nunes PH; Escola de Enfermagem Alfredo Pinto da Universidade do Rio de Janeiro.; This study is a part of a research that comments the relation between Nursing Knowledge and AIDS. The actual period of time is treated like a period of transition between the modern science and one new paradigm. This is called post-modern science. It brings the dynamics of AIDS in Braz
[An unusual case of tuberculosis in an immunocompetent patient]: Arch Bronconeumol. 1997 Oct;33(9):475-7. Unique Identifier : AIDSLINE MED/98057589; Roig Figueroa V; Perez Lucena E; Rodriguez Vidigal F; Ledesma Jurado V; Aguilar Escobar J; Ramirez Gurruchaga P; Unidad de Neumologia, Complejo Hospitalario Llerena-Zafra, Badajoz.; Gastric tuberculosis is a rare entity that often coincides with pulmonary involvement at the time of diagnosis. Many cases reported in developed countries are in immunodepressed patients, particularly those with HIV infection. We report the case of a 43-year-old man who presented with weight loss of 14 kg, persistent
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.: Structure. 1997 Oct 15;5(10):1361-72. Unique Identifier : AIDSLINE MED/98035457; Arold S; Franken P; Strub MP; Hoh F; Benichou S; Benarous R; Dumas C; Centre de Biochimie Structurale, UMR C9955 CNRS, U414 INSERM,; Universite Montpellier I, Faculte de Pharmacie, France.; BACKGROUND: Human immunodeficiency virus (HIV) Nef protein accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of
Polyarthritis with cutaneous mucinosis and intrasynovial mucin deposits.: Rev Rhum Engl Ed. 1997 Oct;64(10):582-5. Unique Identifier : AIDSLINE MED/98046806; Chazerain P; Palazzo E; Bouscarat F; Grossin M; Picard C; Meyer O; Belaich S; Kahn MF; Rheumatology Department (1), Bichat Teaching Hospital, Paris, France.; We report the first case of cutaneous and articular mucinosis with presence of mucin deposits within the synovium in an HIV-positive patients. Presentation was asymmetric polyarthritis, and subcutaneous nodules developed two months later. Treatment was with hydroxychloroquine. The outcome of both the skin and joint le
Number of new AIDS cases in U.S. declines for first time since AIDS/HIV epidemic began [news]: Psychiatr Serv. 1997 Nov;48(11):1481. Unique Identifier : AIDSLINE MED/98016801
HIV risk behaviors [letter]: Psychiatr Serv. 1997 Dec;48(12):1592-3. Unique Identifier : AIDSLINE MED/98069347; McKinnon K
Trimethoprim/sulfamethoxazole incremental dose regimen in human immunodeficiency virus-infected persons.: Ann Allergy Asthma Immunol. 1997 Nov;79(5):409-14. Unique Identifier : AIDSLINE MED/98059105; Rich JD; Sullivan T; Greineder D; Kazanjian PH; Department of Medicine, University of Michigan Medical Ctr, Ann Arbor; 48109-0378, USA.; BACKGROUND: The mechanism of tolerance to incremental doses of trimethoprim-sulfamethoxazole given to human immunodeficiency virus-infected persons who have had a prior intolerance to this agent has not been studied. OBJECTIVE: We prospectively evaluated a regimen of incremental doses of oral trimethoprim-sulfamethoxa
Immunomagnetic selection of purified monocyte and lymphocyte populations from peripheral blood mononuclear cells following cryopreservation.: Clin Diagn Lab Immunol. 1997 Nov;4(6):653-8. Unique Identifier : AIDSLINE MED/98043940; Sleasman JW; Leon BH; Aleixo LF; Rojas M; Goodenow MM; Department of Pediatrics, University of Florida College of Medicine,; Gainesville 32610, USA.; Cryopreservation is a method commonly used to store human blood samples. We sought to determine if cryopreserved peripheral blood mononuclear cells (PBMC) could be separated effectively into distinct populations by using monoclonal antibodies and immunomagnetic microspheres. PBMC obtained from healthy blood donors and
Development of an enzyme-linked immunosorbent assay for measurement of serum-associated ALX40-4C.: Clin Diagn Lab Immunol. 1997 Nov;4(6):671-5. Unique Identifier : AIDSLINE MED/98043943; Payette PJ; Cormier M; Dabek B; Yungblut P; Presseault S; Climie S; Sahai J; Cameron WD; Filion LG; Department of Microbiology and Immunology, University of Ottawa,; Faculty of Medicine, Ontario, Canada.; ALX40-4C is an antiretrovirus agent that has been found to have some inhibitory properties against human immunodeficiency virus HIV) r