The potential roles of 4-1BB costimulation in HIV type 1 infection. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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The potential roles of 4-1BB costimulation in HIV type 1 infection.

AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):223-31. Unique Identifier : AIDSLINE MED/98150876
Wang S; Kim YJ; Bick C; Kim SH; Kwon BS; Department of Microbiology and Immunology, Walther Oncology Center,; Indiana University School of Medicine, Indianapolis 46202, USA.

Abstract: The potential role of 4-1BB in human immunodeficiency virus HIV-1)-infected T cells was investigated with HIV-1-infected subjects. 4-1BB expression was readily inducible on PHA stimulation of T cells from HIV-1-infected individuals. The level of 4-1BB expression and the percentage of 4-1BB-expressing T cells were higher in HIV-1+ individuals than in the HIV-1- controls (p < 0.01). The difference in 4-1BB expression was more significant in CD8+ T cells and the high level of 4-1BB expression was correlated with low CD4+ T cell counts (r = -0.63, p < 0.05). 4-1BB signal cooperated with CD28 for proper HIV-1+ CD4+ T cell proliferation. In addition, cross-linking 4-1BB with agonistic monoclonal antibody enhanced HIV-1 replication both in primary stimulation and secondary restimulation of CD4+ T cells from HIV-1+ individuals. To test whether 4-1BB cross-linking signals an activation of HIV-1, J8-1, a 4-1BB+ Jurkat subline, was transiently transfected with pHIV-1-LTR-CAT plasmid and stimulated through 4-1BB. Combined stimulation of 4-1BB and CD3 resulted in an enhanced CAT activity compared with CD3 stimulation alone. Thus, 4-1BB may be involved in the activation of HIV-1 replication from latently infected CD4+ T cells.
Keywords: *HIV Infections/VIROLOGY *HIV-1/PHYSIOLOGY *Lymphocyte Transformation *Receptors, Nerve Growth Factor/IMMUNOLOGY *Receptors, Nerve Growth Factor/PHYSIOLOGY *Receptors, Tumor Necrosis Factor/IMMUNOLOGY *Receptors, Tumor Necrosis Factor/PHYSIOLOGYKWDhivinfections/virologyKWDhiv-1/physiologyKWDlymphocytetransformationKWDreceptors,nervegrowthfactor/immunologyKWDreceptors,nervegrowthfactor/physiologyKWDreceptors,tumornecrosisfactor/immunologyKWDreceptors,tumornecrosisfactor/physiology
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M9861851

Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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