CD8+/CD57 cells and apoptosis suppress T-cell functions in multiple myeloma. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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CD8+/CD57 cells and apoptosis suppress T-cell functions in multiple myeloma.

Br J Haematol. 1998 Mar;100(3):469-77. Unique Identifier : AIDSLINE MED/98163156
Frassanito MA; Silvestris F; Cafforio P; Dammacco F; Department of Biomedical Sciences and Human Oncology, University of; Bari, Medical School, Italy.

Abstract: The aim of this study was to evaluate the role of CD8+/CD57+ lymphocytes in the immune dysregulation of multiple myeloma (MM). Cytofluorimetry of peripheral blood lymphocytes (PBL) purified from 39 MM patients showed an inverse relationship between the percentage of CD8+/CD57+ cells and CD4/CD8 ratio. Analysis of their activation antigens revealed that they were prevalently HLA-DR+ and Fas+. Removal of CD8+/CD57+ cells from MM PBL significantly improved cell proliferation and pokeweed mitogen PWM)-induced polyclonal Ig production in vitro, whereas the addition of supernatants from patients' CD8+/CD57+ cell cultures to normal PBL suppressed both the PWM-driven Ig synthesis and the proliferative rate of stimulated PBL, supporting the contention that CD8+/CD57+ cells release in vitro an inhibitory factor that is directly involved in T-cell regulatory function. However, since the proliferative recovery of PWM- and phytohaemagglutinin PHA)-stimulated MM PBL in the absence of CD8+/CD57+ lymphocytes was only partial, a dysregulated activation-induced apoptosis was anticipated. In fact, patients' PBL displayed an increased susceptibility to apoptosis and this was significantly enhanced after PWM and, even more, after PHA stimulation. Analysis of CD57 antigen expression on apoptotic or viable cells demonstrated a substantial defect of apoptosis in the CD8+/CD57+ population. Our results indicate that both the immunosuppressive effect of CD8+/CD57+ cells and the enhanced susceptibility to apoptosis of PBL could be involved in the pathogenesis of the immunodeficiency observed in this disease.
Keywords: *Antigens, CD57 *Antigens, CD8 *Apoptosis *Multiple Myeloma/IMMUNOLOGY *T-Lymphocytes/IMMUNOLOGYKWDantigens,cd57KWDantigens,cd8KWDapoptosisKWDmultiplemyeloma/immunologyKWDt-lymphocytes/immunology
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Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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