Deleted HTLV provirus in peripheral blood cells of a patient with T-cell prolymphocytic leukaemia.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Deleted HTLV provirus in peripheral blood cells of a patient with T-cell prolymphocytic leukaemia.

Br J Haematol. 1998 Mar;100(3):567-70. Unique Identifier : AIDSLINE MED/98163170
Kojima K; Sawada T; Yasukawa M; Matsuo Y; Yakushijin Y; Narumi H; Azuma T; Takimoto H; Hara M; Division of Haematology, Ehime Prefectural Central Hospital, Japan.

Abstract: We describe the first case of T-cell prolymphocytic leukaemia T-PLL) in which the peripheral blood cells contained a human T-lymphotropic virus (HTLV) related tax sequence. Serum screening tests for anti-HTLV-I/II antibodies were negative. Polymerase chain reaction disclosed the presence of an HTLV-I tax sequence in the peripheral blood. Other sets of oligonucleotide primers for HTLV-I gag, pol, env and the long terminal repeat regions and for the HTLV-II pol region were negative in the DNA of the cells. Although patients with T-PLL have been reported to be seronegative for HTLV-I, our findings point to the possibility that HTLV-I infection might be involved in the aetiology of at least some cases of T-PLL and that there may be alternative mechanisms involved in HTLV-associated leukaemogenesis.

Keywords: *HTLV-I/ISOLATION & PURIF *Leukemia, Prolymphocytic/VIROLOGY *Proviruses/ISOLATION & PURIF
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M9861837

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