Differential modulation of the immune response by breast- or formula-feeding of infants. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Differential modulation of the immune response by breast- or formula-feeding of infants.

Acta Paediatr. 1997 Dec;86(12):1291-7. Unique Identifier : AIDSLINE MED/98133450
Pabst HF; Spady DW; Pilarski LM; Carson MM; Beeler JA; Krezolek MP; Department of Pediatrics, University of Alberta, Edmonton, Canada.

Abstract: Spontaneous integrin expression on CD4+, CD8+ and CD19+ lymphocytes at 6 months was significantly lower in breastfed than formula-fed infants (p < 0.05). In another study of 59 formula-fed and 64 breastfed 12-month-old children blast transformation and cytokine production by lymphocytes, and T cell changes were measured before and after measles-mumps-rubella vaccination (MMR). Before vaccination, lymphocytes of breastfed children had lower levels of blast transformation without antigen p < 0.001), with tetanus toxoid (p < 0.02) or Candida (p < 0.04), and lower interferon-gamma production (p < 0.03). Fourteen days after the live viral vaccination, only the breastfed children had increased production of interferon-gamma (p < 0.02) and increased percentages of CD56+ (p < 0.022) and CD8+ cells (p < 0.004). These findings are consistent with a Th1 type response by breastfed children, not evident in formula-fed children. Feeding mode has an important long-term immunomodulating effect on infants beyond weaning.
Keywords: *B-Lymphocytes/IMMUNOLOGY *Breast Feeding *CD4-Positive T-Lymphocytes/IMMUNOLOGY *CD8-Positive T-Lymphocytes/IMMUNOLOGY *Infant Food *Measles Vaccine/IMMUNOLOGY *Mumps Vaccine/IMMUNOLOGY *Rubella Vaccine/IMMUNOLOGYKWDb-lymphocytes/immunologyKWDbreastfeedingKWDcd4-positivet-lymphocytes/immunologyKWDcd8-positivet-lymphocytes/immunologyKWDinfantfoodKWDmeaslesvaccine/immunologyKWDmumpsvaccine/immunologyKWDrubellavaccine/immunology
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Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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