The role of CpG dinucleotides in DNA vaccines. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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The role of CpG dinucleotides in DNA vaccines.

Trends Microbiol. 1998 Jan;6(1):23-7. Unique Identifier : AIDSLINE MED/98142819
Krieg AM; Yi AK; Schorr J; Davis HL; University of Iowa, Dept of Internal Medicine, Iowa City 52242, USA.; arthur-krieg@uiowa.edu

Abstract: DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.
Keywords: *CpG Islands/IMMUNOLOGY *Dinucleoside Phosphates/IMMUNOLOGY *Vaccines, DNA/IMMUNOLOGY *Vaccines, DNA/THERAPEUTIC USEKWDcpgislands/immunologyKWDdinucleosidephosphates/immunologyKWDvaccines,dna/immunologyKWDvaccines,dna/therapeuticuse
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Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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