Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study.

J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):291-5. Unique Identifier : AIDSLINE MED/98184340
Gisslen M; Hagberg L; Fuchs D; Norkrans G; Svennerholm B; Department of Infectious Diseases, Goteborg University, Sweden.

Abstract: HIV-1 RNA and neopterin levels were observed longitudinally for 20 to 68 months (mean, 37.5 months) in cerebrospinal fluid (CSF) and serum in 15 HIV-1-infected patients not receiving antiretroviral treatment. During the course of infection the HIV-1 RNA levels increased significantly in CSF, from a mean of 3.08 to 3.51 log10 copies RNA/ml (p < .01). A significant positive correlation was found between the CSF levels of HIV-I RNA and neopterin (rs = 0.54; p < .001), which increased from 13.6 to 19.6 nmol/L (p < .01). No significant changes in HIV-1 RNA or neopterin levels were found in serum. We suggest that the increase of CSF viral load with time in HIV-1 infection triggers an intrathecal immune activation reflected by increased CSF levels of neopterin. These results are in accordance with the theory that a chronic immune stimulation within the central nervous system (CNS) is involved in the pathogenesis of neurologic HIV-1 disease.
Keywords: *Cerebrospinal Fluid/VIROLOGY *HIV Infections/VIROLOGY *HIV-1/PHYSIOLOGY *RNA, Viral/CEREBROSPINAL FLUID *Viral LoadKWDcerebrospinalfluid/virologyKWDhivinfections/virologyKWDhiv-1/physiologyKWDrna,viral/cerebrospinalfluidKWDviralload
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M9861813

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