Comparison of neutralizing and hemagglutination-inhibiting antibody responses to influenza A virus vaccination of human immunodeficiency virus-infected individuals.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Comparison of neutralizing and hemagglutination-inhibiting antibody responses to influenza A virus vaccination of human immunodeficiency virus-infected individuals.

Clin Diagn Lab Immunol. 1998 Jan;5(1):114-7. Unique Identifier : AIDSLINE MED/98115426
Benne CA; Kroon FP; Harmsen M; Tavares L; Kraaijeveld CA; De Jong JC; Eijkman-Winkler Laboratory of Medical Microbiology, University; Hospital Utrecht, The Netherlands.

Abstract: A neutralization enzyme immunoassay (N-EIA) was used to determine the neutralizing serum antibody titers to influenza A/Taiwan/1/86 H1N1) and Beijing/353/89 (H3N2) viruses after vaccination of 51 human immunodeficiency virus (HIV) type 1-infected individuals and 10 healthy noninfected controls against influenza virus infection. Overall, the N-EIA titers correlated well with the hemagglutination-inhibition (HAI) titers that were observed in the same samples in a previous study (F. P. Kroon, J. T. van Dissel, J. C. de Jong, and R. van Furth, AIDS 8:469-476,1994). The N-EIA appeared to be more sensitive than the HAI test. Significantly more fourfold or higher rises in N-EIA titer and higher mean N-EIA titers occurred in HIV-infected individuals with > or =200 CD4+ cells per microl than in those with <200 CD4+ cells per microl.

Keywords: *HIV Infections/PREVENTION & CONTROL *Influenza A Virus/IMMUNOLOGY *Influenza Vaccine/THERAPEUTIC USE *Vaccination
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