The UL6 locus of pseudorabies virus and its homology to oncogenic herpesviruses. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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The UL6 locus of pseudorabies virus and its homology to oncogenic herpesviruses.

Oncol Rep. 1998 Jan-Feb;5(1):115-9. Unique Identifier : AIDSLINE MED/98124637
Pederson NE; Casey JT 2nd; Koslowski KM; Shaver PR; Department of Microbiology and Immunology, East Carolina University; School of Medicine, Greenville, NC, 27858-4354, USA.

Abstract: The UL6 locus of pseudorabies virus (PRV) was analyzed to reveal a gene cluster with homology to herpes simplex virus UL5, UL6, UL7 and UL8, Epstein-Barr virus BBRF1 and BBRF2, and Kaposi sarcoma-associated herpes virus ORF43 and ORF42. The noncoding region between PRV UL7 and UL8 contained 16 copies of a 14 bp T + C-rich repeat element. The mRNA start sites for UL6 and UL7 were mapped by primer extension and UL6 was expressed in vitro. The mobility of the in vitro-expressed UL6 protein correlated with the predicted mass of 66 kDa. The relationship and potential significance of the UL6 locus with the corresponding sequences in oncogenic herpesviruses is discussed.
Keywords: *Capsid/GENETICS *Herpesvirus 1, Suid/GENETICSKWDcapsid/geneticsKWDherpesvirus1,suid/genetics
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