Selective induction of CD8+ T cell functions by single substituted analogs of an antigenic peptide: distinct signals for IL-10 production.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Selective induction of CD8+ T cell functions by single substituted analogs of an antigenic peptide: distinct signals for IL-10 production.

FEBS Lett. 1998 Feb 20;423(2):138-42. Unique Identifier : AIDSLINE MED/98171300
Kohyama M; Kakehi M; Totsuka M; Hachimura S; Hisatsune T; Kaminogawa S; Department of Applied Biological Chemistry, The University of Tokyo,; Japan.

Abstract: The CD8+ T cell clone 5F1 produces interleukin 10 (IL-10) and interferon gamma(IFN-gamma) in response to stimulation with a peptide corresponding to region 142-149 of bovine alpha(s1)-casein (p142-149). Ninety analog peptides derived from p142-149 with single amino acid substitutions of putative T cell receptor contact residues were prepared to examine whether production of IL-10 and IFN-gamma by 5F1 can be altered by stimulation with these peptides. We found that some peptides triggered only IL-10 production whereas others induced production of IFN-gamma alone or both of these cytokines. Peptides inducing IFN-gamma production triggered both cytotoxicity and a proliferative response, whereas peptides inducing production of IL-10 but not IFN-gamma triggered neither of these responses. Our results clearly demonstrate that the signaling pathway required for IL-10 production in CD8+ T cells differs from that required for IFN-gamma production. The distinct cellular signals for IL-10 production appear to be independent of those for cytotoxicity and the proliferative response of CD8+ T cells.

Keywords: *CD8-Positive T-Lymphocytes/PHYSIOLOGY *Interleukin-10/BIOSYNTHESIS *Peptides/PHARMACOLOGY *Signal Transduction/DRUG EFFECTS
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M9861762

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