1998

Access to dental care: changes over time for HIV+/AIDS patients.: Northwest Dent Res. 1997 Spring;7(2):28-30. Unique Identifier : AIDSLINE MED/98148889; Guistino V; Ayer WA; Wilson CJ
T-Cell repertoire in the blood and lungs of atopic asthmatics before and after ragweed challenge.: Am J Respir Cell Mol Biol. 1998 Mar;18(3):370-83. Unique Identifier : AIDSLINE MED/98158673; Yurovsky VV; Weersink EJ; Meltzer SS; Moore WC; Postma DS; Bleecker ER; White B; Department of Medicine, University of Maryland, Baltimore, Maryland; 21201, USA. vyurovsk@umabnet.ab.umd.edu; T cells play a pivotal role in initiating and orchestrating allergic responses in asthma. The goal of this work was to learn whether ragweed challenge in the lungs alters the T-cell repertoire expressed in the blood and lungs of atopic asthmatics. Analyses of cell numbers, differentials, and T-cell subsets in bronchoa
Analysis of the interaction of antibodies with a conserved enzymatically deglycosylated core of the HIV type 1 envelope glycoprotein 120.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):191-8. Unique Identifier : AIDSLINE MED/98150872; Binley JM; Wyatt R; Desjardins E; Kwong PD; Hendrickson W; Moore JP; Sodroski J; Aaron Diamond AIDS Research Center, The Rockefeller University, New; York, New York 10016, USA.; The binding of a panel of monoclonal antibodies to V1, V2, and V3 loop-deleted HIV-1 gp120 was studied by competition analysis. Most of the previously defined relationships between gp120 epitopes were preserved on the variable loop-deleted protein, although interactions between some epitopes were dependent on the pres
Effect of enzymatic deglycosylation on feline immunodeficiency virus sensitivity to antibody-mediated neutralization.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):199-204. Unique Identifier : AIDSLINE MED/98150873; Giannecchini S; Matteucci D; Bendinelli M; Retrovirus Center and Virology Section, Department of Biomedicine,; University of Pisa, Italy.; We have investigated the effect of deglycosylation with peptide-N-glycosidase F (PNGase F) on the sensitivity to inhibition by immune sera of two variants of the Petaluma strain of feline immunodeficiency virus (FIV-Pet), one sensitive to antibody-mediated neutralization because tissue culture adapted and the other, o
Involvement of the complement system in antibody-mediated post-exposure protection against human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):205-11. Unique Identifier : AIDSLINE MED/98150874; Gauduin MC; Weir R; Fung MS; Koup RA; The Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1LAI confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the involvement of the complement system in protection were evaluated in
A human monoclonal antibody specific for the V3 loop of HIV type 1 clade E cross-reacts with other HIV type 1 clades.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):213-21. Unique Identifier : AIDSLINE MED/98150875; Gorny MK; Mascola JR; Israel ZR; VanCott TC; Williams C; Balfe P; Hioe C; Brodine S; Burda S; Zolla-Pazner S; New York University Medical Center, New York 10016, USA.; To ascertain the antigenic relationship between HIV-1 viruses belonging to various genetically defined subgroups (clades), shared epitopes need to be defined. Human monoclonal antibodies MAbs) are particularly useful for this purpose because they can detect complex regions of viral proteins that may be missed by seque
The potential roles of 4-1BB costimulation in HIV type 1 infection.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):223-31. Unique Identifier : AIDSLINE MED/98150876; Wang S; Kim YJ; Bick C; Kim SH; Kwon BS; Department of Microbiology and Immunology, Walther Oncology Center,; Indiana University School of Medicine, Indianapolis 46202, USA.; The potential role of 4-1BB in human immunodeficiency virus HIV-1)-infected T cells was investigated with HIV-1-infected subjects. 4-1BB expression was readily inducible on PHA stimulation of T cells from HIV-1-infected individuals. The level of 4-1BB expression and the percentage of 4-1BB-expressing T cells were high
Inhibition of HIV type 1 BaL replication by MIP-1alpha, MIP-1beta, and RANTES in macrophages.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):233-40. Unique Identifier : AIDSLINE MED/98150877; Capobianchi MR; Abbate I; Antonelli G; Turriziani O; Dolei A; Dianzani F; Institute of Virology, University La Sapienza, Rome, Italy.; The beta-chemokines RANTES, MIP-1alpha, and MIP-1beta have been shown to inhibit the infection of T cells by macrophage-tropic HIV-1 strains by blocking env-driven HIV-1 fusion through competition for the chemokine receptors or receptor downregulation. This study was aimed at testing whether beta-chemokines also inhib
Nonsynonymous mutations within the human immunodeficiency virus type 1 p17 gene are clustered to sequences binding to the host human leukocyte antigen class I molecules.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):241-8. Unique Identifier : AIDSLINE MED/98150878; Birk M; Vahlne A; Sonnerborg A; Sallberg M; Division of Clinical Virology, Huddinge University Hospital, Sweden.; We have analyzed the relation between intrapatient variabilities of the p17 gene and the location of known host p17 cytotoxic T lymphocyte (CTL) epitopes in five patients infected with human immunodeficiency virus type 1 (HIV-1). All patients were typed with respect to the human leukocyte antigen (HLA) class I type. O
Lamivudine resistance of HIV type 1 does not delay development of resistance to nonnucleoside HIV type 1-specific reverse transcriptase inhibitors as compared with wild-type HIV type 1.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):249-53. Unique Identifier : AIDSLINE MED/98150879; Jonckheere H; Witvrouw M; De Clercq E; Anne J; Rega Institute for Medical Research, Leuven, Belgium.; We compared the development of resistance toward BI-RG-587 nevirapine ) and alpha-APA R89439 (loviride) starting from the wild-type HIV-1 strain IIIB and the 3TC-resistant HIV-1 strain containing the M184V mutation. The reverse transcriptase of the M18
A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):255-60. Unique Identifier : AIDSLINE MED/98150880; Balzarini J; Pelemans H; Esnouf R; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium. Jan.Balzarini@rega.kuleuven.ac.be; Treatment of wild-type human immunodeficiency virus [HIV-1(IIIB)]-infected cell cultures with the thiocarboxanilide UC-781 under low selective pressure (i.e., 0.01 microg/ml) resulted in the emergence of V106A RT mutant virus. On increasing drug concentrations (stepwise up to 30 microg/ml) the virus retained the V106A
Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):261-7. Unique Identifier : AIDSLINE MED/98150881; Arai M; Kannagi M; Matsuoka M; Sato T; Yamamoto N; Fujii M; Department of Immunotherapeutics, Medical Research Division, Tokyo; Medical and Dental University, Yushima, Japan.; Human T cell leukemia virus type 1 (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with an autoimmune condition. We examined the sensitivity of HTLV-I-infected T cell lines to Fas-mediated apoptosis, which plays a critical role in the elimination of self-reactive
Severe combined immunodeficient mice engrafted with macaque peripheral blood leukocytes support replication of SIVsmm.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):269-74. Unique Identifier : AIDSLINE MED/98150882; Schwiebert RS; Fultz PN; Department of Microbiology, University of Alabama School of Medicine,; Birmingham 35294, USA.; Peripheral blood leukocytes (PBLs) from normal pigtail macaques were engrafted into severe combined immunodeficient C.B-17 scid/scid (SCID) mice to develop a small animal model in which to study and identify genetic determinants responsible for the acutely lethal disease syndrome induced by SIVsmmPBj14 SIV-PBj14) in p
Partial protection by vaccination with recombinant feline immunodeficiency virus surface glycoproteins.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):275-83. Unique Identifier : AIDSLINE MED/98150883; Leutenegger CM; Hofmann-Lehmann R; Holznagel E; Cuisinier AM; Wolfensberger C; Duquesne V; Cronier J; Allenspach K; Aubert A; Ossent P; Lutz H; Clinical Laboratory, Department of Internal Veterinary Medicine,; University of Zurich, Switzerland. christi8@vetklinik.unizh.ch; In an effort to induce a strong immune response that might protect against feline immunodeficiency virus (FIV) challenge infection, three groups of five specified pathogen-free (spf) cats each were immunized subcutaneously with different FIV antigen preparations. Immunizations were done at weeks 0, 2, and 4 with 100 m
Cloning and characterization of a virtually full-length HIV type 1 genome from a subtype B'-Thai strain representing the most prevalent B-clade isolate in China.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):285-8. Unique Identifier : AIDSLINE MED/98150884; Graf M; Shao Y; Zhao Q; Seidl T; Kostler J; Wolf H; Wagner R; Institute of Medical Microbiology, University of Regensburg, Germany.
Full-length sequence of human immunodeficiency virus type 1 subtype A, recombined with subtype C in the env V3 domain.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):289-92. Unique Identifier : AIDSLINE MED/98150885; Sherefa K; Johansson B; Salminen M; Sonnerborg A; Division of Clinical Virology, Karolinska Institute, Huddinge; University Hospital, Stockholm, Sweden.
Species-dependent enantioselective pharmacokinetics of PNU-103017, a pyrone HIV protease inhibitor.: Chirality. 1998;10(3):210-6. Unique Identifier : AIDSLINE MED/98160547; Zhong WZ; Williams MG; Borin MT; Padbury GE; Pharmacia & Upjohn, Kalamazoo, MI 49001, USA. wzhong@am.pnu.com; PNU-103017, 4-Cyano-N-(3-(cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy- 2-oxo-2H-cycloocta(b) pyran-3-yl)methyl)phenyl)-benzenesulfonamide, is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immunodeficiency Diseases. PNU-103017 is a racemic mixture of two enantio
[Care of children with HIV infection]: Kinderkrankenschwester. 1997 Dec;16(12):516-8. Unique Identifier : AIDSLINE MED/98131454; Czudzewitz U; Bennauer M; Hohendahl J; Nageler-Kokott H; Backes E; Grosse S; Klinik fur Kinder- und Jugendmedizin, Ruhr-Universitat Bochum.
Management of adult T-cell leukaemia/lymphoma.: Br J Haematol. 1998 Mar;100(3):453-8. Unique Identifier : AIDSLINE MED/98163153; Pawson R; Mufti GJ; Pagliuca A; Department of Haematology, Royal Free Hospital, London.
CD8+/CD57 cells and apoptosis suppress T-cell functions in multiple myeloma.: Br J Haematol. 1998 Mar;100(3):469-77. Unique Identifier : AIDSLINE MED/98163156; Frassanito MA; Silvestris F; Cafforio P; Dammacco F; Department of Biomedical Sciences and Human Oncology, University of; Bari, Medical School, Italy.; The aim of this study was to evaluate the role of CD8+/CD57+ lymphocytes in the immune dysregulation of multiple myeloma (MM). Cytofluorimetry of peripheral blood lymphocytes (PBL) purified from 39 MM patients showed an inverse relationship between the percentage of CD8+/CD57+ cells and CD4/CD8 ratio. Analysis of thei
Deleted HTLV provirus in peripheral blood cells of a patient with T-cell prolymphocytic leukaemia.: Br J Haematol. 1998 Mar;100(3):567-70. Unique Identifier : AIDSLINE MED/98163170; Kojima K; Sawada T; Yasukawa M; Matsuo Y; Yakushijin Y; Narumi H; Azuma T; Takimoto H; Hara M; Division of Haematology, Ehime Prefectural Central Hospital, Japan.; We describe the first case of T-cell prolymphocytic leukaemia T-PLL) in which the peripheral blood cells contained a human T-lymphotropic virus (HTLV) related tax sequence. Serum screening tests for anti-HTLV-I/II antibodies were negative. Polymerase chain reaction disclosed the presence of an HTLV-I tax sequence in t
The platelet and endothelium in HIV infection [letter]: Br J Haematol. 1998 Mar;100(3):613-4. Unique Identifier : AIDSLINE MED/98163186; Blann A; Constans J; Dignat-George F; Seigneur M
[Species identification of intestinal microsporidiosis in HIV-positive patients using the polymerase chain reaction]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):456-61. Unique Identifier : AIDSLINE MED/98096939; del Aguila C; Soriano V; Navajas R; Subirats M; Fenoy S; Valencia E; Baquero M; Pieniazek NJ; Seccion de Parasitologia, Facultad de Ciencias Experimentales y; Tecnicas, Universidad San Pablo-CEU, Madrid.; BACKGROUND: Microsporidia are opportunistic parasites which, due to their morphologic characteristics, continue presenting diagnostic problems. Species-specific identification of microsporidia has become important because of varying levels of response to albendazole, which is the only effective treatment for some kind
[Patients with human immunodeficiency virus admitted to the emergency service of a general hospital]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):468-72. Unique Identifier : AIDSLINE MED/98096941; Iglesias ML; Pedro-Botet J; Hernandez E; Villalta R; Alvarez A; Gutierrez J; Skaf E; Servicio de Urgencias, Hospital del Mar, Universidad Autonoma de; Barcelona.; BACKGROUND: The description of the demographic, toxicologic, immunologic and clinicopathologic characteristics of patients with known human immunodeficiency virus infection (HIV) admitted to hospital through the emergency department is presented. METHODS: A cohort study of patients with known HIV seropositivity who co
[Diarrhea caused by Cryptosporidium as the initial manifestation of AIDS in an elderly man (letter)]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):495-6. Unique Identifier : AIDSLINE MED/98096948; Velasco M; Pintor E; Piret MV; Barreiro P; Ruiz M; Hernandez MJ
[Persistent bacteremia and infection of an intravascular device by Agrobacterium radiobacter (tumefaciens) in a boy with AIDS letter)]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):496-7. Unique Identifier : AIDSLINE MED/98096949; Salavert M; Breton JR; Perez-Tamarit D; Perez-Belles C; Gobernado M
[Tuberculous abscess simulating complicated acute appendicitis in a patient with HIV infection (letter)]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):497-8. Unique Identifier : AIDSLINE MED/98096950; Pintor E; Velasco M; Piret MV; Minguez P; Ruiz M
[Epiglottitis caused by Haemophilus influenzae type b in a patient with AIDS (letter)]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):499-500. Unique Identifier : AIDSLINE MED/98096952; Moro MJ; Gutierrez J; Gorgolas M
Differential modulation of the immune response by breast- or formula-feeding of infants.: Acta Paediatr. 1997 Dec;86(12):1291-7. Unique Identifier : AIDSLINE MED/98133450; Pabst HF; Spady DW; Pilarski LM; Carson MM; Beeler JA; Krezolek MP; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Spontaneous integrin expression on CD4+, CD8+ and CD19+ lymphocytes at 6 months was significantly lower in breastfed than formula-fed infants (p
Gender differences in care for acquired immunodeficiency syndrome-related Pneumocystis carinii pneumonia.: Womens Health Issues. 1998 Jan-Feb;8(1):45-52. Unique Identifier : AIDSLINE MED/98164789; Bastian LA; Sloane RJ; DeHovitz JA; Bennett CL; Center for Health Services Research in Primary Care, Durham Veteran; Affairs Medical Center, North Carolina, USA.
Familial transmission of human T-lymphotropic virus type 1 HTLV-1) in patients with adult T-cell leukemia/lymphoma or HTLV-1-associated myelopathy.: J Formos Med Assoc. 1998 Feb;97(2):101-5. Unique Identifier : AIDSLINE MED/98170595; Hu CY; Lin MT; Yang YC; Tang JL; Tseng LH; Wang CH; Chen YC; Yang CS; School of Medical Technology, College of Medicine, National Taiwan; University, Taipei, Taiwan.; The seroprevalence of human T-lymphotropic virus type 1 (HTLV-1) in Taiwan is 0.48%. In this study, we investigated the patterns of intrafamilial transmission of HTLV-1 in Taiwanese patients with adult T-cell leukemia/lymphoma (ATL/
Recombinant coagulation factors.: Blood Rev. 1997 Dec;11(4):169-77. Unique Identifier : AIDSLINE MED/98142446; Roddie PH; Ludlam CA; Department of Haematology, Royal Infirmary of Edinburgh, UK.; The advent of technology that has allowed production of recombinant proteins on an industrial scale has revolutionized haemophilia care. Recombinant coagulation factors, as opposed to their plasma-derived counterparts, have a very low risk for transmission of infectious agents and their use should eradicate the threat
The prevalence of Enterocytozoon bieneusi in acquired immunodeficiency syndrome (AIDS) patients from the north west of England: 1992-1995.: Br J Biomed Sci. 1997 Sep;54(3):186-91. Unique Identifier : AIDSLINE MED/98160571; Kyaw T; Curry A; Edwards-Jones V; Craske J; Mandal BK; Public Health Laboratory, Withington Hospital, Manchester, England,; UK.; Microsporidia are increasingly being recognised as important enteric pathogens in patients with advanced human immunodeficiency virus (HIV) disease, i.e. acquired immunodeficiency syndrome (AIDS). The aims of this study were to investigate the frequency of detection of microsporidia associated with diarrhoea in patien
Microsporidial infections in humans: current practice and developments in laboratory diagnosis.: Br J Biomed Sci. 1997 Sep;54(3):216-21. Unique Identifier : AIDSLINE MED/98160574; Windsor JJ; Department of Microbiology and Immunology, College of Medicine, Sultan; Qaboos University, Muscat, Sultanate of Oman.; Microsporidia are small, intracellular parasites that infect a wide range of hosts, including vertebrates, invertebrates and fish. They were discovered more than a century ago. The first well documented human case, however, was not reported until 100 years later. Since the first case of intestinal
Differences by ancestry in sociodemographics and risk behaviors among Latinos with AIDS. The Supplement to HIV and AIDS Surveillance Project Group.: Ethn Dis. 1997 Autumn;7(3):200-6. Unique Identifier : AIDSLINE MED/98128883; Diaz T; Klevens M; Centers for Disease Control and Prevention, Division of HIV and AIDS; Prevention, Atlanta, GA 30333, USA.; To describe differences by ancestry, we interviewed 1,785 self-identified Latinos who have been reported to have acquired immunodeficiency syndrome from 12 state or local health departments. Central American men and women were the least acculturated group: > 90% were born outside the USA, and more than half answered t
The patient showing HIV infection [news]: Natl Med J India. 1997 Nov-Dec;10(6):298-9. Unique Identifier : AIDSLINE MED/98142104; Pandya SK
[Pilot study of the characteristics of transfused patients and utilized labile blood products]: Transfus Clin Biol. 1997 Dec;4(6):533-40. Unique Identifier : AIDSLINE MED/98108958; Mathoulin-Pelissier S; Vicariot M; Gross S; Waller C; Courtois F; Eghbali H; Saves M; Verret C; Salmi LR; Centre national d'hemovigilance, Bordeaux.; The aim of this study was to describe blood recipients and blood components transfused during the first 24 hours in 13 French hospitals. We included all blood recipients who had not had any blood transfusion within the past six months. Recipients were screened for red cell alloantibodies, the alanine aminotransferase
Tuberculosis in the hospice--a cause for concern?: Palliat Med. 1997 Nov;11(6):469-74. Unique Identifier : AIDSLINE MED/98179694; McKeogh MM; Mildmay Mission Hospital, London, UK.; Open pulmonary tuberculosis has been increasingly seen in HIV-infected patients in this hospice. Multidrug-resistant tuberculosis is a new and serious threat and two cases have occurred in our hospice in the past two years. This infection poses a health risk to staff, patients, relatives and volunteers. Palliative car
AIDS-associated biliary tract disease [letter]: J Am Coll Surg. 1998 Mar;186(3):373-4. Unique Identifier : AIDSLINE MED/98169091; Barie PS
Transplacental antibody transfer and neonatal immunity.: Br J Hosp Med. 1997 Oct 1-14;58(7):317-9. Unique Identifier : AIDSLINE MED/98169785; de Moraes-Pinto I; Hart CA; Department of Medical Microbiology and Genito-Urinary Medicine,; University of Liverpool.
The role of CpG dinucleotides in DNA vaccines.: Trends Microbiol. 1998 Jan;6(1):23-7. Unique Identifier : AIDSLINE MED/98142819; Krieg AM; Yi AK; Schorr J; Davis HL; University of Iowa, Dept of Internal Medicine, Iowa City 52242, USA.; arthur-krieg@uiowa.edu; DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventi
Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans.: QJM. 1998 Jan;91(1):13-8. Unique Identifier : AIDSLINE MED/98179732; Bellamy R; Ruwende C; McAdam KP; Thursz M; Sumiya M; Summerfield J; Gilbert SC; Corrah T; Kwiatkowski D; Whittle HC; Hill AV; Wellcome Trust Centre for Human Genetics, Oxford University, UK.; We retrospectively studied MBP genotypes in patients with malaria, tuberculosis (TB), and persistent hepatitis B virus HBV) carriage, in clinics and hospitals in The Gambia . Children under 10 years with cerebral malaria and/or severe malarial anaemia, were compared with children wi
Treatment of Felty's syndrome with the haemopoietic growth factor granulocyte colony-stimulating factor (G-CSF).: QJM. 1998 Jan;91(1):49-56. Unique Identifier : AIDSLINE MED/98179736; Stanworth SJ; Bhavnani M; Chattopadhya C; Miller H; Swinson DR; Department of Haematology, Manchester Royal Infirmary.; Felty s syndrome (FS) (rheumatoid arthritis with neutropenia and splenomegaly) has a poor prognosis, largely because of the high risk of severe infection. Granulocyte colony-stimulating factor G-CSF) is an emerging treatment for chronic neutropenia. We prospectively monitored its use in eight patients with recurrent i
The 2nd National AIDS Malignancy Conference. Bethesda, Maryland, USA. April 6-8, 1998. Abstracts.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):A1-43. Unique Identifier : AIDSLINE MED/98192040
Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):291-5. Unique Identifier : AIDSLINE MED/98184340; Gisslen M; Hagberg L; Fuchs D; Norkrans G; Svennerholm B; Department of Infectious Diseases, Goteborg University, Sweden.; HIV-1 RNA and neopterin levels were observed longitudinally for 20 to 68 months (mean, 37.5 months) in cerebrospinal fluid (CSF) and serum in 15 HIV-1-infected patients not receiving antiretroviral treatment. During the course of infection the HIV-1 RNA levels increased significantly in CSF, from a mean of 3.08 to 3.5
Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):296-302. Unique Identifier : AIDSLINE MED/98184341; Balzarini J; Cahard D; Wedgwood O; Salgado A; Velazquez S; Yarnold CJ; De Clercq E; McGuigan C; Thormar H; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; Lipophilic masked aryloxyaminoacylphosphoramidate derivatives of 2 ,3 -dideoxynucleoside (ddN) analogues with potent anti-HIV activity (i.e., stavudine [ d4T ], azidothymidine [
Unintegrated circular HIV-1 DNA in the peripheral mononuclear cells of HIV-1-infected subjects: association with high levels of plasma HIV-1 RNA, rapid decline in CD4 count, and clinical progression to AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):303-13. Unique Identifier : AIDSLINE MED/98184342; Panther LA; Coombs RW; Zeh JE; Collier AC; Corey L; Department of Medicine, University of Washington, Seattle, USA.; We observed 36 HIV-infected patients to evaluate whether the presence of tandem 2-long terminal repeat circular unintegrated HIV-1 DNA (2-LTR) in peripheral blood mononuclear cells (PBMC) at baseline was associated with acceleration of HIV disease. Detection of 2-LTR at baseline correlated with high plasma HIV-1 RNA l
Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):314-9. Unique Identifier : AIDSLINE MED/98184343; Palefsky JM; Holly EA; Hogeboom CJ; Ralston ML; DaCosta MM; Botts R; Berry JM; Jay N; Darragh TM; Department of Laboratory Medicine, University of California-San; Francisco 94143, USA.; Anal cancer may be preceded by anal squamous intraepithelial lesions (ASIL), but the natural history of ASIL is poorly understood. In this report, we characterize the 2-year incidence and progression of low-grade SIL (LSIL) and high-grade SIL (HSIL) in a cohort study in 346 HIV-positive and 262 HIV-negative homosexual
Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):320-6. Unique Identifier : AIDSLINE MED/98184344; Palefsky JM; Holly EA; Ralston ML; Arthur SP; Jay N; Berry JM; DaCosta MM; Botts R; Darragh TM; Department of Laboratory Medicine, University of California-San; Francisco, 94143, USA.; Anal cancer is more commonly found in homosexual and bisexual men than cervical cancer is in women. Invasive anal cancer may be preceded by anal squamous intraepithelial lesions (ASIL), and treatment of ASIL may prevent the development of anal cancer. We characterized the prevalence and risk factors for ASIL in 346 HI
Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):327-31. Unique Identifier : AIDSLINE MED/98184345; Stafford MK; Ward H; Flanagan A; Rosenstein IJ; Taylor-Robinson D; Smith JR; Weber J; Kitchen VS; Department of Genitourinary Medicine and Communicable Diseases,; Chelsea and Westminster Hospital, England.; Nonoxynol-9 (N-9) is virucidal in vitro, and is therefore a candidate microbicide for preventing sexual transmission of HIV. However, the activity of N-9 is nonspecific, suggesting that virucidal levels may produce adverse effects including epithelial disruption, inflammation of the genital mucosa, or both. A randomiz
Laboratory test differences associated with HTLV-I and HTLV-II infection. Retrovirus Epidemiology Donor Study Investigators.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):332-8. Unique Identifier : AIDSLINE MED/98184346; Murphy EL; Glynn S; Watanabe K; Fridey J; Smith J; Sacher R; Wright D; Schreiber G; Luban N; University of California San Francisco 94143-0884, USA.; murphy@labmed.ucsf.edu; Reports of laboratory abnormalities associated with HTLV-I and HTLV-II infection are inconsistent. We assessed complete blood counts and selected serum chemistry measures at enrollment in a cohort of 153 HTLV-I-seropositive, 386 HTLV-II-seropositive, and 795 HTLV-seronegative blood donors. Linear and logistic regressi
Randomized, controlled study of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):339-44. Unique Identifier : AIDSLINE MED/98184347; Lalezari JP; Holland GN; Kramer F; McKinley GF; Kemper CA; Ives DV; Nelson R; Hardy WD; Kuppermann BD; Northfelt DW; Youle M; Johnson M; Lewis RA; Weinberg DV; Simon GL; Wolitz RA; Ruby AE; Stagg RJ; Jaffe HS; University of California, San Francisco-Mt. Zion Medical Center, USA.; To assess the effect of intravenous cidofovir on delaying progression of previously treated, relapsing cytomegalovirus CMV ) retinitis, we conducted a randomized, controlled comparison of two maintenance dose levels of cidofov
Size and duration of zidovudine benefit in 1003 HIV-infected patients: U.S. Army, Navy, and Air Force natural history data. Military Medical Consortium for Applied Retroviral Research.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):345-53. Unique Identifier : AIDSLINE MED/98184348; Gardner LI; Harrison SH; Hendrix CW; Blatt SP; Wagner KF; Chung RC; Harris RW; Cohn DL; Burke DS; Mayers DL; Division of Preventive Medicine, Walter Reed Army Institute of; Research, Washington, DC, USA.; OBJECTIVES: The study s objectives were to determine the size and duration of benefits of early versus delayed versus late treatment with zidovudine (ZDV) on disease progression and mortality in HIV-infected patients, and whether patients rapidly progressing before ZDV treatment had a different outcome from those not
Evaluating the cost of medications for ambulatory HIV-infected persons in association with landmark changes in antiretroviral therapy.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):354-60. Unique Identifier : AIDSLINE MED/98184349; Perdue BE; Weidle PJ; Everson-Mays RE; Bozek PS; Department of Pharmacy Services, University of Maryland Medical; System, Baltimore, USA.; Costs of medications for ambulatory HIV-infected people increase as knowledge of antiretroviral therapy and therapy for opportunistic infection grows. We evaluated the evolution of drug costs for HIV-infected persons who attend a university clinic in Baltimore, Maryland. Cross-sectional abstracts of a cohort of patien
Interpretation of indeterminate HIV serology results in an incarcerated population.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):376-9. Unique Identifier : AIDSLINE MED/98184352; Rich JD; Dickinson BP; Spaulding A; Lafazia L; Flanigan TP; The Miriam Hospital and Brown University, Providence, Rhode Island; 02906, USA.; The objective of this study was to evaluate the significance of indeterminate HIV test results in the prison setting. No specific information or guidelines are currently available to direct counseling of incarcerated persons with an indeterminate HIV test. A medical chart review was conducted on all incarcerated inmat
Prevalence of HTLV-I in leprosy patients in two sanatoriums in Japan.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):380-3. Unique Identifier : AIDSLINE MED/98184353; Muneishi H; Taguchi H; Sawada T; Ikezoe T; Matsui S; Tanaka S; Taniguchi T; Onoue O; Miyoshi I; Department of Internal Medicine, Kochi Medical School, Japan.; To determine the association between leprosy and HTLV-I, 450 and 394 leprosy patients in two sanatoriums in Japan (Sanatorium-A in Okayama prefecture and Sanatorium-B in Gunma prefecture) were investigated serologically for antibodies to HTLV-I. Serology was positive for HTLV-I in 3
Occupational blood exposure and HIV infection among oral and maxillofacial surgeons.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Feb;85(2):128-34. Unique Identifier : AIDSLINE MED/98164185; Gooch BF; Siew C; Cleveland JL; Gruninger SE; Lockwood SA; Joy ED; Centers for Disease Control and Prevention, Atlanta, Ga., USA.; OBJECTIVE: The purpose of this study was to examine occupational blood exposure and the seroprevalence of HIV infection among oral and maxillofacial surgeons. STUDY DESIGN: Three hundred twenty-one oral and maxillofacial surgeons attending an annual meeting voluntarily and anonymously participated in an HIV serosurvey
Comparison of neutralizing and hemagglutination-inhibiting antibody responses to influenza A virus vaccination of human immunodeficiency virus-infected individuals.: Clin Diagn Lab Immunol. 1998 Jan;5(1):114-7. Unique Identifier : AIDSLINE MED/98115426; Benne CA; Kroon FP; Harmsen M; Tavares L; Kraaijeveld CA; De Jong JC; Eijkman-Winkler Laboratory of Medical Microbiology, University; Hospital Utrecht, The Netherlands.; A neutralization enzyme immunoassay (N-EIA) was used to determine the neutralizing serum antibody titers to influenza A/ Taiwan /1/86 H1N1) and Beijing/353/89 (H3N2) viruses after vaccination of 51 human immunodeficiency virus (HIV) t
Distribution of CCR5delta32 in human immunodeficiency virus-infected children and its relationship to disease course.: Clin Diagn Lab Immunol. 1998 Jan;5(1):38-40. Unique Identifier : AIDSLINE MED/98115412; Bakshi SS; Zhang L; Ho D; Than S; Pahwa SG; Department of Pediatrics, North Shore University Hospital-New York; University School of Medicine, Manhasset, USA.; Homozygosity for a 32-bp deletion in the CCR5 gene (CCR5delta32) has been shown to confer resistance to infection with the macrophage-tropic strain of human immunodeficiency virus (HIV) type 1. We examined the distribution of CCR5delta32 in 47 children (age range, 1.5 to 19 years), of whom 43 were infected with HIV, b
Depressed phagocytosis and oxidative burst in polymorphonuclear leukocytes from individuals with pulmonary tuberculosis with or without human immunodeficiency virus type 1 infection.: Clin Diagn Lab Immunol. 1998 Jan;5(1):41-4. Unique Identifier : AIDSLINE MED/98115413; Shalekoff S; Tiemessen CT; Gray CM; Martin DJ; National Institute for Virology, and Department of Virology,; University of the Witwatersrand, Johannesburg, South Africa.; SharonS@niv.ac.za; Phagocytosis and oxidative burst in whole-blood granulocytes were assessed by flow cytometry with Phagotest and Bursttest kits, respectively. Seventy individuals were included in this study: 15 healthy, normal donors, 18 human immunodeficiency virus (HIV) type 1 (HIV-1)-seropositive patients, 19 patients with pulmonar
Assessment of a new immunoassay for serological confirmation and discrimination of human T-cell lymphotropic virus infections.: Clin Diagn Lab Immunol. 1998 Jan;5(1):45-9. Unique Identifier : AIDSLINE MED/98115414; Zrein M; Louwagie J; Boeykens H; Govers L; Hendrickx G; Bosman F; Sablon E; Demarquilly C; Boniface M; Saman E; Innogenetics NV, Ghent, Belgium. maanzre@innogenetics.be; The present study evaluated a new confirmatory assay for antibodies to human T-cell lymphotropic virus type 1 and 2 HTLV-1 and HTLV-2) proteins performed with serum samples from various commercial sources. The new test is a line immunoassay LIA) with a nylon membrane sensitized with the most relevant antigens of HTLVs
HEp-2 cell-adherent Escherichia coli and intestinal secretory immune response to human immunodeficiency virus (HIV) in outpatients with HIV-associated diarrhea.: Clin Diagn Lab Immunol. 1998 Jan;5(1):87-90. Unique Identifier : AIDSLINE MED/98115422; Mathewson JJ; Salameh BM; DuPont HL; Jiang ZD; Nelson AC; Arduino R; Smith MA; Masozera N; Center for Infectious Diseases, The University of Texas School of; Public Health and Medical School, Houston 77030, USA.; JMATHEWSON@UTSPH.SPH.UTH.TMC.EDU; HEp-2 cell-adherent Escherichia coli and the human immunodeficiency virus (HIV) itself have recently been incriminated as causes of chronic HIV-associated diarrhea. This study sought to determine the prevalence of these two agents among HIV-infected patients with diarrhea in an outpatient setting in the
Enhancement of antibody-dependent cellular cytotoxicity of neonatal cells by interleukin-2 (IL-2) and IL-12.: Clin Diagn Lab Immunol. 1998 Jan;5(1):98-104. Unique Identifier : AIDSLINE MED/98115424; Nguyen QH; Roberts RL; Ank BJ; Lin SJ; Lau CK; Stiehm ER; Department of Pediatrics, Children's Hospital, University of; California at Los Angeles, 90095, USA.; Newborn infants are more susceptible to infections due in part to deficiencies in the cytotoxic functions of their lymphocytes. We investigated the ability of interleukin-2 ( IL-2 ) and IL-12 to enhance the cytotoxicity of neonatal (cord blood) and adult mononuclear cell
CCR2 polymorphism and HIV disease. Swiss HIV Cohort [letter]: Nat Med. 1998 Mar;4(3):252-3. Unique Identifier : AIDSLINE MED/98160216; Rizzardi GP; Morawetz RA; Vicenzi E; Ghezzi S; Poli G; Lazzarin A; Pantaleo G
Cancelled trial exposes Japanese research deficiencies [news]: Nat Med. 1998 Mar;4(3):260. Unique Identifier : AIDSLINE MED/98160223; Saegusa A
Chemokine genes--beating the odds [news; comment]: Nat Med. 1998 Mar;4(3):275-7. Unique Identifier : AIDSLINE MED/98160233; Stewart G
Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection: implications for antiviral therapy.: Nat Med. 1998 Mar;4(3):341-5. Unique Identifier : AIDSLINE MED/98160246; Pantaleo G; Cohen OJ; Schacker T; Vaccarezza M; Graziosi C; Rizzardi GP; Kahn J; Fox CH; Schnittman SM; Schwartz DH; Corey L; Fauci AS; Laboratory of AIDS Immunopathogenesis, Department of Medicine, Centre; Hospitalier Vadois, Lausanne, Switzerland.; Evolutionary patterns of virus replication and distribution in lymphoid tissue during the early phases of HIV infection have not been delineated. Lymph node (LN) biopsies were excised from patients at different times after the estimated time of primary infection. Within 3 months of the acute viral syndrome, HIV was mo
Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency.: Nat Med. 1998 Mar;4(3):346-9. Unique Identifier : AIDSLINE MED/98160247; Glushakova S; Grivel JC; Fitzgerald W; Sylwester A; Zimmerberg J; Margolis LB; Laboratory of Cellular and Molecular Biophysics, National Institute of; Child Health and Human Development, National Institutes of Health,; Bethesda, Maryland 20892-1855, USA.; Both cellular and humoral immunodeficiency develop in vivo after prolonged infection with HIV-1, but the mechanisms are unclear. Initial infection with HIV-1 is transmitted by macrophage M)-tropic/non-syncytia-inducing (NSI) viruses, which hyperactivate the immune system, and, in one view, cause immunodeficiency by e
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation [see comments]: Nat Med. 1998 Mar;4(3):350-3. Unique Identifier : AIDSLINE MED/98160248; Kostrikis LG; Huang Y; Moore JP; Wolinsky SM; Zhang L; Guo Y; Deutsch L; Phair J; Neumann AU; Ho DD; The Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, respectively. Most new infections involve transmission of R5 viruses, but variants can arise la
Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors.: Nat Med. 1998 Mar;4(3):354-7. Unique Identifier : AIDSLINE MED/98160249; Poeschla EM; Wong-Staal F; Looney DJ; Department of Medicine, University of California San Diego, La Jolla; 92093-0655, USA.; The molecular bases for species barriers to lentiviral replication are not well understood, but are of interest for explaining lentiviral pathogenesis, devising therapeutic strategies, and adapting lentiviruses to gene therapy. HIV-1-based lentiviral vectors efficiently transduce nondividing cells, but present complex
Sperm head agglutination induced by V3 peptide does not occur through a CD4 receptor.: Chung Hua I Hsueh Tsa Chih (Taipei). 1998 Jan;61(1):24-8. Unique Identifier : AIDSLINE MED/98170428; Ou MC; Tzeng CR; Ng HT; Department of Obstetrics and Gynecology, Taipei Medical College; Hospital, Taiwan, ROC.; BACKGROUND: Although recent studies have shown that HIV (human immunodeficiency virus) can attach to sperm, the mechanism by which it does this is not yet understood. It has been shown that CD4 receptors on T4 cells are responsible for the binding of gp120 (glycoprotein 120) to HIV; however, the existence of CD4 recep
A fatal case of Rhodotorula meningitis in AIDS.: Med Health R I. 1998 Jan;81(1):22-3. Unique Identifier : AIDSLINE MED/98134206; Ahmed A; Aggarwal M; Chiu R; Ramratnam B; Rinaldi M; Flanigan TP; Division of Gastroenterology, Stanford University School of Medicine,; CA 94305-5487, USA.
Candida dubliniensis: an emerging opportunistic pathogen.: Curr Top Med Mycol. 1997 Dec;8(1-2):15-25. Unique Identifier : AIDSLINE MED/98164814; Sullivan D; Coleman D; Department of Oral Surgery, Oral Medicine and Oral Pathology, School; of Dental Science, University of Dublin, Trinity College, Ireland.; djsullvn@tcd.ie; The incidence of opportunistic fungal infections continues to increase, partly as a result of the continuing AIDS epidemic. Candida albicans remains the most important fungal pathogen and is frequently associated with oral candidiasis in HIV-infected individuals. Over the past decade, however, there has been an increa
Penicillium marneffei infection in patients infected with human immunodeficiency virus.: Curr Top Med Mycol. 1997 Dec;8(1-2):35-42. Unique Identifier : AIDSLINE MED/98164816; Vanittanakom N; Sirisanthana T; Faculty of Medicine, Chiang Mai University, Thailand.; Opportunistic infections are major causes of morbidity in patients with human immunodeficiency virus (HIV) infection. Penicillium marneffei infection is very common in HIV-infected individuals in northern Thailand . The patients usually present with fever, anemia, weight loss, ski
High-performance liquid chromatographic determination of ritonavir in human plasma, cerebrospinal fluid and saliva.: J Chromatogr B Biomed Sci Appl. 1998 Jan 23;705(1):119-26. Unique Identifier : AIDSLINE MED/98158443; Hoetelmans RM; van Essenberg M; Profijt M; Meenhorst PL; Mulder JW; Beijnen JH; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; A simple, ion-pair high-performance liquid chromatographic method has been developed and validated for the quantitative determination of the HIV protease inhibitor ritonavir in human plasma, cerebrospinal fluid and saliva. Sample pretreatment consiste
The UL6 locus of pseudorabies virus and its homology to oncogenic herpesviruses.: Oncol Rep. 1998 Jan-Feb;5(1):115-9. Unique Identifier : AIDSLINE MED/98124637; Pederson NE; Casey JT 2nd; Koslowski KM; Shaver PR; Department of Microbiology and Immunology, East Carolina University; School of Medicine, Greenville, NC, 27858-4354, USA.; The UL6 locus of pseudorabies virus (PRV) was analyzed to reveal a gene cluster with homology to herpes simplex virus UL5, UL6, UL7 and UL8, Epstein-Barr virus BBRF1 and BBRF2, and Kaposi sarcoma-associated herpes virus ORF43 and ORF42. The noncoding region between PRV UL7 and UL8 contained 16 copies of a 14 bp T + C-
Functionally and phenotypically mature mouse CD8+ T cells develop in porcine thymus grafts in mice.: Xenotransplantation. 1998 Feb;5(1):99-104. Unique Identifier : AIDSLINE MED/98168584; Zhao Y; Barth RN; Swenson K; Pearson DA; Sykes M; Bone Marrow Transplantation Section, Massachusetts General; Hospital/Harvard Medical School, Boston 02129, USA.; Mouse CD4+ T cells efficiently develop in fetal pig thymus (FP THY) grafts and repopulate the periphery of T cell and NK cell-depleted, thymectomized (ATX) mice. However, efficient peripheral repopulation of mouse CD8+ T cells does not occur in these mice. We have therefore evaluated the maturation and function of mou
Inhibition of methadone and buprenorphine N-dealkylations by three HIV-1 protease inhibitors.: Drug Metab Dispos. 1998 Mar;26(3):257-60. Unique Identifier : AIDSLINE MED/98160431; Iribarne C; Berthou F; Carlhant D; Dreano Y; Picart D; Lohezic F; Riche C; Laboratoires de Biochimie-Nutrition EA948, Faculte de Medecine, Brest,; France.; Ritonavir , indinavir, and saquinavir, all human immunodeficiency virus-1 protease inhibitors with a potent antiviral effect during triple therapy, are extensively metabolized by liver cytochrome P45
Schizophrenic patients before and after HIV infection: a case-control study.: Encephale. 1997 Nov-Dec;23(6):437-41. Unique Identifier : AIDSLINE MED/98150184; Mauri MC; Fabiano L; Bravin S; Ricci C; Invernizzi G; Department of Clinical Psychiatry, University of Milan, IRCCS,; Ospedale Maggiore di Milano, Italy.; Thirteen HIV positive schizophrenic patients (Group 1), age ranging from 23 to 60 years, diagnosed as schizophrenics (DSM IV), were studied during a four week hospitalization period, due to an acute exacerbation phase. The patients were treated with haloperidol (3-15 mg/die p.o.) and diazepam (2-25 mg/die p.o.). Clini
[Epidemiology of psychopathologic disorders in infectious diseases]: Encephale. 1997 Dec;23 Spec No 5:3-8. Unique Identifier : AIDSLINE MED/98150171; Pelissolo A; Service de Psychiatrie, Hopital Fernand-Widal, Paris.
[Neuropsychiatric complications and HIV infection in the adult]: Encephale. 1997 Dec;23 Spec No 5:30-5. Unique Identifier : AIDSLINE MED/98150176; Bouvet O; Centre Hospitalier Ste-Anne, Paris.
[Psychologic effect of HIV infection. Occasional support by psychoanalytic consultation]: Encephale. 1997 Dec;23 Spec No 5:36-42. Unique Identifier : AIDSLINE MED/98150177; Duval F; Navelet C; Psychologue Clinicien, Hopital Rotschild, Paris.
[Depressive states during severe infectious illnesses]: Encephale. 1997 Dec;23 Spec No 5:9-13. Unique Identifier : AIDSLINE MED/98150172; Salmon D; Mercuel A; Hopital Cochin, Paris.
Selective tolerization of Th1-like cells after nasal administration of a cholera toxoid-LACK conjugate.: Eur J Immunol. 1998 Feb;28(2):424-32. Unique Identifier : AIDSLINE MED/98180344; McSorley SJ; Rask C; Pichot R; Julia V; Czerkinsky C; Glaichenhaus N; Centre National de la Recherche Scientifique, Institut de; Pharmacologie Moleculaire et Cellulaire, Valbonne, France.; mcsor001@tc.umn.edu; Recent reports have suggested that after infection of BALB/c mice with Leishmania major, CD4+ T cells responding to a single antigen, LACK (Leishmania homologue of receptors for activated C kinase), drive the differentiation of other responding T cells to the Th2 phenotype and so allow lesion development to occur. Tra
The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb.: Eur J Immunol. 1998 Feb;28(2):525-31. Unique Identifier : AIDSLINE MED/98180357; Ferlin WG; von der Weid T; Cottrez F; Ferrick DA; Coffman RL; Howard MC; Department of Immunobiology, DNAX Research Institute, Palo Alto, CA,; USA.; A protective immune response to the intracellular parasite Leishmania major requires the development of a Th1 CD4+ T cell phenotype. We demonstrate herein that BALB/c mice, which normally develop a susceptible Th2 response to L. major infection, are protected when co-injected with an agonistic anti-murine CD40 mAb. An
Stable polarization of peripheral blood T cells towards type 1 or type 2 phenotype after polyclonal activation.: Eur J Immunol. 1998 Feb;28(2):532-9. Unique Identifier : AIDSLINE MED/98180358; Asselin S; Conjeaud H; Minty A; Fradelizi D; Breban M; INSERM U477, Hopital Cochin, Universite Rene Descartes, Paris, France.; Polarization of T lymphocytes towards type 1 (T1) or type 2 (T2) subsets producing a distinct array of cytokines plays a role in several diseases and could be used for therapeutic intervention. Bearing this purpose in mind, we have established suitable in vitro conditions to drive resting polyclonal human T cells towa
Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection.: Eur J Immunol. 1998 Feb;28(2):560-9. Unique Identifier : AIDSLINE MED/98180361; Petschner F; Zimmerman C; Strasser A; Grillot D; Nunez G; Pircher H; Institute for Medical Microbiology and Hygiene, Department of; Immunology, University of Freiburg, Germany.; We examined the CD8+ T cell response to lymphocytic choriomeningitis virus (LCMV) in mice doubly transgenic for an LCMV-specific TCR and for either bcl-xL or bcl-2. Clonal down-sizing of the anti-viral CD8+ T cell response and the generation of T cell memory was not influenced by constitutive expression of these anti-
CD40 ligand and IFN-gamma synergistically restore IL-12 production in HIV-infected patients.: Eur J Immunol. 1998 Feb;28(2):646-56. Unique Identifier : AIDSLINE MED/98180370; Chougnet C; Thomas E; Landay AL; Kessler HA; Buchbinder S; Scheer S; Shearer GM; Experimental Immunology Branch, National Cancer Institute, Bethesda,; MD 20892, USA.; IL-12 production in HIV-infected (HIV+) individuals is severely impaired after stimulation by bacterial products or T cell-dependent stimuli. Because CD40-CD40 ligand (CD40L) interactions are the major mechanism involved in the T cell-dependent activation of antigen-presenting cells, we investigated whether this pathw
Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani.: Eur J Immunol. 1998 Feb;28(2):669-80. Unique Identifier : AIDSLINE MED/98180372; Engwerda CR; Murphy ML; Cotterell SE; Smelt SC; Kaye PM; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, GB. c.engwerda@lshtm.ac.uk; IL-12 plays a key role in stimulating both innate and antigen-specific immune responses against a number of intracellular pathogens. A neutralizing anti-IL-12 monoclonal antibody (mAb) was used to define and compare the role of endogenous IL-12 in the liver and spleen of mice infected with Leishmania donovani. IL-12 n
Antigen dose-dependent differences in IgE antibody production are not due to polarization towards Th1 and Th2 cell subsets.: Eur J Immunol. 1998 Feb;28(2):681-6. Unique Identifier : AIDSLINE MED/98180373; Arps V; Sudowe S; Kolsch E; Institute for Immunology, University of Munster, Germany.; arps@uni-muenster.de; The quality of the humoral immune response against protein antigens in CBA/J mice is dependent on the antigen dose used for immunization: low doses induce high titers of IgE antibodies, whereas high doses promote the production of IgG2a antibodies but inhibit IgE formation. To investigate whether the reciprocal regula
A T cell activation antigen, Ly6C, induced on CD4+ Th1 cells mediates an inhibitory signal for secretion of IL-2 and proliferation in peripheral immune responses.: Eur J Immunol. 1998 Feb;28(2):696-707. Unique Identifier : AIDSLINE MED/98180375; Yamanouchi S; Kuwahara K; Sakata A; Ezaki T; Matsuoka S; Miyazaki J; Hirose S; Tamura T; Nariuchi H; Sakaguchi N; Department of Immunology, Kumamoto University School of Medicine,; Honjo, Japan.; A T cell activation antigen, Ly6C, is considered to be involved in the autoimmunity of some autoimmune-prone mice; however, the function of Ly6C remains largely unknown. We prepared a rat anti-mouse Ly6C monoclonal antibody (mAb) (S14) that inhibits the proliferation of peripheral T cells stimulated with anti-CD3 mAb
[Mortality among drug addicts: an Italian multicenter study. ESEDA group (Epidemiological Studies on Effects of Drug Abuse)]: Epidemiol Prev. 1997 Oct-Dec;21(4):265-71. Unique Identifier : AIDSLINE MED/98150486; To investigate temporal and geographical differences in mortality of intravenous drug users (IDUs) in Italy , a multicenter cohort of IDUs entering public treatment centres in Turin (n = 6975), Rome (n = 4660), Naples (n = 3785) and Cagliari (n = 1630) between 1980-1992, was enrolled
Determinants of squamous intraepithelial lesions (SIL) on Pap smear: the role of HPV infection and of HIV-1-induced immunosuppression. DIANAIDS Collaborative Study Group.: Eur J Epidemiol. 1997 Dec;13(8):937-43. Unique Identifier : AIDSLINE MED/98135692; Rezza G; Giuliani M; Branca M; Benedetto A; Migliore G; Garbuglia AR; D'Ubaldo C; Pezzotti P; Cappiello G; Pomponi Formiconi D; Suligoi B; Schiesari A; Ippolito G; Giacomini G; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome, Italy.; This study aimed to identify risk factors for squamous intraepithelial lesions (SIL) in women with known HIV status and to explore the association between SIL, HPV subtype, and HIV-induced immunosuppression. The study population consisted of women with known HIV serological status who were attending a network of 16 cl
Decreasing age at infection for homosexually acquired HIV in Italy: results of a back-calculation analysis.: Eur J Epidemiol. 1997 Dec;13(8):963-6. Unique Identifier : AIDSLINE MED/98135696; Marschner IC; Bosch RJ; Harvard School of Public Health, Boston 02115, USA.; marsch@sdac.harvard.edu; The age-specific incidence of homosexually acquired HIV in Italy was examined, based on 3918 AIDS cases diagnosed by the end of 1994 and reported by the end of 1995 through the national surveillance system. Using a smoothed back-calculation analysis, the estimated median age at infe
Characterization of the internal promoter of human T-cell leukemia virus type I.: FEBS Lett. 1998 Feb 13;423(1):25-30. Unique Identifier : AIDSLINE MED/98165680; Ariumi Y; Shimotohno K; Noda M; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.; The HTLV-I provirus contains two different promoters: the classical retroviral promoter in the 5 long terminal repeat LTR) and our previously identified second promoter in the pol gene just upstream of the ATG codon of the tax gene. Here, we demonstrated that the internal promoter expresses the gene for Tax but not R
Selective induction of CD8+ T cell functions by single substituted analogs of an antigenic peptide: distinct signals for IL-10 production.: FEBS Lett. 1998 Feb 20;423(2):138-42. Unique Identifier : AIDSLINE MED/98171300; Kohyama M; Kakehi M; Totsuka M; Hachimura S; Hisatsune T; Kaminogawa S; Department of Applied Biological Chemistry, The University of Tokyo,; Japan.; The CD8+ T cell clone 5F1 produces interleukin 10 (IL-10) and interferon gamma(IFN-gamma) in response to stimulation with a peptide corresponding to region 142-149 of bovine alpha(s1)-casein (p142-149). Ninety analog peptides derived from p142-149 with single amino acid substitutions of putative T cell receptor contac
HIV screening for pregnant women in south eastern France: evolution 1992-1994-1996.: Eur J Obstet Gynecol Reprod Biol. 1998 Jan;76(1):5-9. Unique Identifier : AIDSLINE MED/98142537; Rey D; Obadia Y; Carrieri MP; Moatti JP; Observatoire Regional de la Sante, Marseille, France.; OBJECTIVES: To assess the evolution of the HIV screening practices towards pregnant women between 1992 and 1996, in relation with the 1993 French mandatory obligation to offer prenatal HIV testing and recent therapeutic possibilities to reduce HIV vertical transmission. STUDY DESIGN: Three successive surveys (January
Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x.: Diabetologia. 1998 Feb;41(2):178-84. Unique Identifier : AIDSLINE MED/98158416; Lamhamedi-Cherradi SE; Luan JJ; Eloy L; Fluteau G; Bach JF; Garchon HJ; INSERM U25 and Institut Necker, Hopital Necker, Paris, France.; Activated lymphocytes of autoimmune non-obese diabetic (NOD) mice exhibit an increased resistance to programmed cell death (PCD) following withdrawal of interleukin-2 ( IL-2 ). In the present study, we found that resistance of NOD T lymphocytes to PCD was increased as ea
Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice.: Diabetologia. 1998 Feb;41(2):237-40. Unique Identifier : AIDSLINE MED/98158425; Tian J; Chau C; Kaufman DL; Department of Molecular and Medical Pharmacology, University of; California, Los Angeles 90095-1735, USA.; Little is known about the immunological impact of insulin administration other than it can boost insulin autoantibody levels. In particular, while the subcutaneous administration of a soluble foreign antigen (without adjuvant) is generally only weakly immunogenic in a naive animal, it is unknown what effect the subcut
Extra protection is prudent, not discriminatory [letter]: Gen Dent. 1997 Jul-Aug;45(4):332-3; discussion 334-8. Unique Identifier : AIDSLINE MED/98176416; Goleburn G
Ethics, or opinion? [letter]: Gen Dent. 1997 Jul-Aug;45(4):333-8. Unique Identifier : AIDSLINE MED/98176417; Gherardi RJ
Exploring ethical foundations [letter]: Gen Dent. 1997 Jul-Aug;45(4):334-8. Unique Identifier : AIDSLINE MED/98176418; Eichler D
First report of a healthy Indian heterozygous for delta 32 mutant of HIV-1 co-receptor-CCR5 gene.: Gene. 1998 Jan 30;207(2):141-7. Unique Identifier : AIDSLINE MED/98172746; Husain S; Goila R; Shahi S; Banerjea A; Laboratory of Virology, National Institute of Immunology, New Delhi,; India.; The beta-chemokine receptor, CCR5, is a major co-receptor for macrophage tropic non-syncytia-inducing isolates of HIV-1. Recently a 32 bp homozygous deletion in the coding region of CCR5 has been reported in a very small percentage (
The sodA gene of Haemophilus ducreyi encodes a hydrogen peroxide-inhibitable superoxide dismutase.: Gene. 1998 Jan 30;207(2):251-7. Unique Identifier : AIDSLINE MED/98172759; San Mateo LR; Toffer KL; Kawula TH; Department of Microbiology and Immunology, School of Medicine,; University of North Carolina at Chapel Hill 27599, USA.; Haemophilus ducreyi is the etiologic agent of the sexually transmitted disease chancroid, an ulcerative condition implicated in increased HIV transmission. There is increasing evidence for the roles of oxidative stress proteins including superoxide dismutase enzymes in the survival and persistence of pathogenic organi
Thrombophilic condition in HIV-infected patients [letter]: Haematologica. 1997 Nov-Dec;82(6):733-4. Unique Identifier : AIDSLINE MED/98160663; Trotti R; Rondanelli M; Anesi A
CD8+ T-cell clones in old mice.: Immunol Rev. 1997 Dec;160:139-44. Unique Identifier : AIDSLINE MED/98137153; Ku CC; Kotzin B; Kappler J; Marrack P; Howard Hughes Medical Institute, National Jewish Medical and Research; Center, Denver, Colorado 80206, USA.; Most old mice and human beings contain large clones of CD8+ alpha beta TCR+ T cells. In mice, clones bearing V beta 7 appear more frequently in animals infected with mouse hepatitis virus than in uninfected animals. This property is controlled by some non-MHC gene in the animals. The frequency of old mice containing s
Prevalence of HBsAg in patients with HIV infection and AIDS [letter]: Indian J Gastroenterol. 1998 Jan;17(1):35-6. Unique Identifier : AIDSLINE MED/98126668; Sehgal S; Mujtaba S
[Combination treatment of HIV infection]: Internist (Berl). 1997 Dec;38(12):1146-53. Unique Identifier : AIDSLINE MED/98126459; Goebel FD; Bogner JR; Medizinische Poliklinik der Ludwig-Maximilians-Universitat, Munchen.
Worldwide distribution of HTLV.: Jpn J Cancer Res. 1998 Jan;89(1):inside front cover. Unique Identifier : AIDSLINE MED/98169288; Tajima K; Division of Epidemiology, Aichi Cancer Center Research Institute,; Nagoya, Japan.
Characterization of mRNA expression of IkappaB alpha and NF-kappaB subfamilies in primary adult T-cell leukemia cells.: Jpn J Cancer Res. 1998 Jan;89(1):53-9. Unique Identifier : AIDSLINE MED/98169298; Inoue M; Matsuoka M; Yamaguchi K; Takatsuki K; Yoshida M; Department of Cellular and Molecular Biology, The Institute of Medical; Science, The University of Tokyo.; Tax protein of HTLV-1 activates the transcriptional capacity of the NF-kappaB family, resulting in up-regulation of various genes, which are linked to phenotypic alterations of HTLV-1-infected T cells. To understand NF-kappaB regulation in HTLV-1-infected leukemic cells in vivo, we analyzed expression of NF-kappaB and
Adsorptive endocytosis mediates the passage of HIV-1 across the blood-brain barrier: evidence for a post-internalization coreceptor.: J Cell Sci. 1998 Feb;111 ( Pt 4):533-40. Unique Identifier : AIDSLINE MED/98107969; Banks WA; Akerstrom V; Kastin AJ; Veterans Affairs Medical Center and Tulane Univeristy School of; Medicine, New Orleans, LA 70146, USA. bbbpts@mailhost.tcs.tulane.edu; HIV-1 induces the AIDS dementia complex and infects brain endothelial and glial cells. Because the endothelial cells comprising the blood-brain barrier (BBB) do not possess CD4 receptors or galactosylceramide binding sites, it is unclear how HIV-1 negotiates the BBB. Previous work
Breaking the silence, dismantling taboos: Latino novels on AIDS.: J Homosex. 1998;34(3-4):155-75. Unique Identifier : AIDSLINE MED/98166128; Sandoval Sanchez A; Department of Spanish, Mount Holyoke College, South Hadley, MA 01075,; USA.; As AIDS has ravaged the world in the last two decades, literature has played an important role in giving testimony of the epidemic. According to different communities and particular experiences, AIDS literature can offer ways of coping and surviving. In the last few years the U.S. Latino/a population has been highly a
Construction and characterization of a radio-iodinatable mutant of recombinant human CD4.: J Immunol Methods. 1997 Dec 29;210(2):215-25. Unique Identifier : AIDSLINE MED/98179127; Ferrer M; Godbout KL; Sullivan BJ; Austen DA; Sanderson CT; Kelley KC; Osburne MS; Harrison SC; van Schravendijk MR; Department of Molecular and Cellular Biology, Harvard University,; Cambridge, MA 02138, USA.; Recombinant soluble human CD4 (rsCD4) has been used in iodinated form to study the interaction of CD4 with its ligands. However, the utility of [125I]-rsCD4 is limited because rsCD4 is inefficiently iodinated and the iodinated protein is poorly active. The iodination properties of rsCD4 most likely reflect the poor ac
Widening social inequalities in mortality: the case of Barcelona, a southern European city.: J Epidemiol Community Health. 1997 Dec;51(6):659-67. Unique Identifier : AIDSLINE MED/98179653; Borrell C; Plasencia A; Pasarin I; Ortun V; Municipal Institute of Health, Barcelona, Spain.; OBJECTIVE: To analyse trends in mortality inequalities in Barcelona between 1983 and 1994 by comparing rates in those electoral wards with a low socioeconomic level and rates in the remaining wards. DESIGN: Mortality trends study. SETTING: The city of Barcelona ( Spain ). SUBJECTS: Th
Epidemiology of hepatitis C virus infection among injecting drug users in Australia.: J Epidemiol Community Health. 1997 Dec;51(6):692-7. Unique Identifier : AIDSLINE MED/98179658; Crofts N; Jolley D; Kaldor J; van Beek I; Wodak A; Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria,; Australia.; STUDY OBJECTIVE: To review the epidemiology of hepatitis C virus HCV) infection among injecting drug users (IDUs) in Australia , and consider needs for further research and prevention policies and programmes. DESIGN: (1) Review of the results of surveillance for HCV; (2) review o
CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease.: J Exp Med. 1998 Mar 16;187(6):855-64. Unique Identifier : AIDSLINE MED/98167922; Cong Y; Brandwein SL; McCabe RP; Lazenby A; Birkenmeier EH; Sundberg JP; Elson CO; Division of Gastroenterology and Hepatology, The University of Alabama; at Birmingham, Birmingham, Alabama 35294-0007, USA.; C3H/HeJBir mice are a new substrain that spontaneously develop colitis early in life. This study was done to determine the T cell reactivity of C3H/HeJBir mice to candidate antigens that might be involved in their disease. C3H/HeJBir CD4+ T cells were strongly reactive to antigens of the enteric bacterial flora, but n
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.: J Exp Med. 1998 Mar 16;187(6):875-83. Unique Identifier : AIDSLINE MED/98167924; Sallusto F; Lenig D; Mackay CR; Lanzavecchia A; Basel Institute for Immunology, CH-4005, Basel, Switzerland.; sallusto@bii.ch; Chemokines and their receptors are important elements for the selective attraction of various subsets of leukocytes. To better understand the selective migration of functional subsets of T cells, chemokine receptor expression was analyzed using monoclonal antibodies, RNase protection assays, and the response to distin
The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy.: J Exp Med. 1998 Mar 16;187(6):949-59. Unique Identifier : AIDSLINE MED/98167931; Tenner-Racz K; Stellbrink HJ; van Lunzen J; Schneider C; Jacobs JP; Raschdorff B; Grosschupff G; Steinman RM; Racz P; Medical Department, Eppendorf University, 20251 Hamburg, Germany.; The efficacy of triple drug therapy for HIV-1 infection encourages its early use to prevent damage to the immune system. We monitored the effects of such therapy on 12 patients with 14-75-mo histories of minimal disease, i.e., CD4+ counts constantly >500/microl and little or no lymph node enlargement. In this way, we
Comparison of protein surfaces using a genetic algorithm.: J Comput Aided Mol Des. 1997 Nov;11(6):557-69. Unique Identifier : AIDSLINE MED/98152048; Poirrette AR; Artymiuk PJ; Rice DW; Willett P; Krebs Institute for Biomolecular Research, Department of Information; Studies, University of Sheffield, U.K.; A genetic algorithm (GA) is described which is used to compare the solvent-accessible surfaces of two proteins or fragments of proteins, represented by a dot surface calculated using the Connolly algorithm. The GA is used to move one surface relative to the other to locate the most similar surface region between the t
Congenital and perinatal cytomegalovirus infection in infants born to mothers infected with human immunodeficiency virus.: J Pediatr. 1998 Feb;132(2):285-90. Unique Identifier : AIDSLINE MED/98165486; Mussi-Pinhata MM; Yamamoto AY; Figueiredo LT; Cervi MC; Duarte G; Department of Pediatrics, Faculty of Medicine of Ribeirao Preto,; University of Sao Paulo, Brazil.; OBJECTIVES: To determine the rates of congenital and perinatal cytomegalovirus ( CMV ) infection among infants born to mothers infected with HIV compared with infants born to mothers not infected with HIV from a CMV-immune, low
[Imaging of AIDS in children]: J Radiol. 1997 Dec;78(12):1233-43. Unique Identifier : AIDSLINE MED/98160943; Geoffray A; Spehl M; Chami M; Bosson N; Toppet V; Deville A; Fondation Lenval, Nice.; In children, AIDS is mainly related to materno-foetal transmission. Due to antiviral therapy and prevention of infections, the initially very poor prognosis has improved and the length of survival has increased. There are two groups of children: the first (25%) in which the disease occurs early and is very severe, a s
Infections and cancer: viruses are still prime suspects [news]: J Natl Cancer Inst. 1998 Mar 18;90(6):418-20. Unique Identifier : AIDSLINE MED/98180458; McCann J
[HIV screening in maternity clinics]: Katilolehti. 1998 Jan;103(1):23-4. Unique Identifier : AIDSLINE MED/98166574; Parviainen M; With a decision of the Finnish Department of Health and Social Welfare the HIV-screenings have been extended from the beginning of the year. The most important reason for this is the development of the medical treatment. With the present treatment, the transmitting of the HIV-infection from mother to child can be prev
The effect of exercise training on aerobic fitness, immune indices, and quality of life in HIV+ patients.: Med Sci Sports Exerc. 1998 Jan;30(1):11-6. Unique Identifier : AIDSLINE MED/98133786; Stringer WW; Berezovskaya M; O'Brien WA; Beck CK; Casaburi R; Harbor-UCLA Medical Center, Division of Respiratory and Critical, Care; Physiology and Medicine, Torrance, CA 90509, USA.; PURPOSE: Thirty four HIV+ patients participated in a 6-wk aerobic exercise training program to determine whether exercise improved aerobic fitness, immune indices, and quality of life. METHODS: Subjects were assigned to three groups: control (no regular aerobic exercise), moderate exercise, and heavy exercise training
Production of TNFalpha and IL-6 by activated whole blood from HIV-1 infected patients detected by a one-stage procedure: relationship with the phenotype of HIV-1 isolates.: Microbiol Immunol. 1997;41(12):939-46. Unique Identifier : AIDSLINE MED/98151143; Benyoucef S; Hober D; Shen L; Ajana F; De Groote D; Bocket-Mouton L; Gerard Y; Lion G; Vilain V; Wattre P; Laboratoire de Virologie, CHU, Lille, France.; Diluted whole blood (WB) culturing may be the most appropriate milieu in which to study cytokine production in vitro. We tested TNFalpha and IL-6 production using small volumes of WB (25 microl) from HIV-1 positive patients with a one-step procedure that combines WB stimulation with LPS, PHA and cytokine measurement.
Bioactive fragment of human IL-1beta [163-171] modulates the immune response to synthetic peptides of HIV.: Microbiol Immunol. 1997;41(12):965-74. Unique Identifier : AIDSLINE MED/98151146; Gokulan K; Rao DN; Department of Biochemistry, All India Institute of Medical Sciences,; New Delhi.; The activation of T helper cells specific for viral antigens is critical for antibody production and the generation of cytotoxic T cells during retroviral infection. In this study, we examined the effect of linking HIV peptides with a bioactive fragment of human interleukin-1beta (IL-1beta) (163-171) on the induction
Application of equine infectious anemia virus core proteins produced in a baculovirus expression system to serological diagnosis.: Microbiol Immunol. 1997;41(12):975-80. Unique Identifier : AIDSLINE MED/98151147; Kong XG; Pang H; Sugiura T; Sentsui H; Onodera T; Matsumoto Y; Akashi H; National Institute of Animal Health, Tsukuba, Ibaraki, Japan.; Equine infectious anemia virus (EIAV) core proteins were obtained from a baculovirus expression system. Recombinant baculoviruses rBVs) highly expressed the Gag precursor and p26 antigens in an rBV-infected Sf21 cell culture supernatant. Enzyme-linked immunosorbent assay (ELISA) and agar gel immunodiffusion (AGID) wer
Mechanisms of allografted tumor rejection: the roles of T cells in allograft rejection mediated by a type of bone marrow-derived macrophage.: Microbiol Immunol. 1997;41(12):981-90. Unique Identifier : AIDSLINE MED/98151148; Ushio-Umeda Y; Yoshida R; Department of Cell Biology, Osaka Bioscience Institute, Suita, Japan.; Allografted tumor rejection does not occur in the absence of T cells, but the main effector cells responsible for the rejection are allograft-induced macrophages (AIM). We examined the roles of T cells in the AIM-mediated rejection of Meth A (H-2d) tumor cells from C57BL/6 (H-2b) mice. Irradiation of C57BL/6 mice abro
[HIV infection: antiretroviral therapy 1997. Consensus statement of the International AIDS Society-USA Panel]: Med Monatsschr Pharm. 1997 Dec;20(12):343-6. Unique Identifier : AIDSLINE MED/98096987
Sexual transmission and the natural history of human herpesvirus 8 infection.: N Engl J Med. 1998 Apr 2;338(14):948-54. Unique Identifier : AIDSLINE MED/98172957; Martin JN; Ganem DE; Osmond DH; Page-Shafer KA; Macrae D; Kedes DH; Center for AIDS Prevention Studies, Department of Epidemiology and; Biostatistics, San Francisco General Hospital, CA, USA.; BACKGROUND: Although human herpesvirus 8 (HHV-8) has been suspected to be the etiologic agent of Kaposi s sarcoma, little is known about its seroprevalence in the population, its modes of transmission, and its natural history. METHODS: The San Francisco Men s Health Study, begun in 1984, is a study of a population-bas
Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus.: Neuroscience. 1998 Apr;83(3):691-700. Unique Identifier : AIDSLINE MED/98144547; Krucker T; Toggas SM; Mucke L; Siggins GR; Scripps Research Institute and AIDS Research Center, Department of; Neuropharmacology, La Jolla, CA 92037, USA.; The human immunodeficiency virus type-1 envelope glycoprotein gp120 is shed from the virus and from infected cells and thus can diffuse and interact with a variety of central nervous system cells. Transgenic mice constitutively expressing glial fibrillary acidic protein-driven gp120 from brain astrocytes display neuro
Home medical tests increase in use and popularity.: N J Med. 1998 Feb;95(2):27-9. Unique Identifier : AIDSLINE MED/98166402; Noonan SS
HIV resources [letter]: N J Med. 1998 Feb;95(2):8. Unique Identifier : AIDSLINE MED/98166397; Apuzzio J
Making sense of the law [letter]: N J Med. 1998 Feb;95(2):8, 12. Unique Identifier : AIDSLINE MED/98166398; Harris C
Transient increase in CD45RO expression on T lymphocytes in infected newborns.: Pediatr Res. 1998 Feb;43(2):283-90. Unique Identifier : AIDSLINE MED/98133445; Tezuka T; Sugita K; Mizobe N; Goi K; Miyamoto N; Nakamura M; Kagami K; Yokoyama T; Nakazawa S; Department of Pediatrics, Yamanashi Medical University, Japan.; Although infections are a significant cause of mortality and long-term morbidity of newborns, the early diagnosis of neonatal infections remains difficult. It has been shown recently that up-regulation of CD45RO expression on umbilical cord lymphocytes might be a good indicator for intrauterine viral infections. To ev
AIDS and dentistry: 1997.: Northwest Dent. 1997 Jan-Feb;76(1):19-23, 25-8, 30-4. Unique Identifier : AIDSLINE MED/98148862; Rhodus NL; Little JW; University of Minnesota School of Dentistry, Minneapolis 55455, USA.
Mutational analysis of the tRNA3Lys/HIV-1 RNA (primer/template) complex.: Nucleic Acids Res. 1998 Mar 1;26(5):1198-204. Unique Identifier : AIDSLINE MED/98136200; Isel C; Keith G; Ehresmann B; Ehresmann C; Marquet R; Unite Propre de Recherche No. 9002 du Centre National de la Recherche; Scientifique, Institut de Biologie Moleculaire et Cellulaire, 15 rue; Rene Descartes, 67084 Strasbourg cedex, France.; Retroviruses use a specific tRNA, whose 3 end is complementary to the 18 nucleotides of the primer binding site (PBS), to prime reverse transcription. Previous work has shown that initiation of HIV-1 reverse transcription is a specific process, in contrast with the subsequent elongation phase. HIV-1 reverse transcrip
Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.: Nucleic Acids Res. 1998 Mar 1;26(5):1294-301. Unique Identifier : AIDSLINE MED/98136213; Greger IH; Demarchi F; Giacca M; Proudfoot NJ; Sir William Dunn School of Pathology, University of Oxford, South; Parks Road, Oxford OX1 3RE, UK.; Transcriptional interference between adjacent genes has been demonstrated in a variety of biological systems. To study this process in RNA polymerase II (pol II) transcribed genes we have analysed the effect of transcription on tandem HIV-1 promoters integrated into the genome of HeLa cells. We show that transcription
Specific cleavage of a target RNA from HIV-1 by mammalian tRNA 3' processing endoribonuclease directed by an RNA heptamer.: Nucleic Acids Symp Ser. 1997;(36):22-5. Unique Identifier : AIDSLINE MED/98138682; Nashimoto M; Kaspar R; JT Life Science Research Laboratory, Kanagawa, Japan.; Mammalian tRNA 3 processing endoribonuclease (3 tRNase) can recognize pre-tRNA-like complexes between a 5 half tRNA(Arg) and a 3 half tRNA(Arg) with a 3 trailer, and can cleave the 3 half tRNA(Arg) after the discriminator nucleotide (Nashimoto M., 1996, RNA, 2:523-534). 3 tRNase cleaved the 3 half tRNA(Arg) in
Rational and combinatorial strategies for designing oligonucleotides targeted to RNA structures.: Nucleic Acids Symp Ser. 1997;(36):39-41. Unique Identifier : AIDSLINE MED/98138687; Toulme JJ; Le Tinevez R; Boiziau C; Dausse E; INSERM U386, IFR Pathologies Infectieuses, Universite Victor Segalen,; Bordeaux, France.; Many RNA structures play a key role in the regulation of gene expression. We designed synthetic oligonucleotides able to interact with folded RNA regions (see Toulme et al., Biochimie 1996) 78, 663-673, for a review). We have demonstrated that a decanucleotide can form a triple helix with the stem of the hairpin respo
The effect of pseudouridine and pH on the structure and dynamics of the anticodon stem-loop of tRNA(Lys,3).: Nucleic Acids Symp Ser. 1997;(36):56-7. Unique Identifier : AIDSLINE MED/98138692; Durant PC; Davis DR; Department of Medicinal Chemistry, University of Utah, Salt Lake City; 84112, USA.; The anticodon stem-loop hairpin of tRNA(Lys,3) was synthesized and the solution structure determined by NMR spectroscopy. The hairpin is thermodynamically stabilized by pseudouridine as determined by UV Tm measurements, and the local loop structure is stabilized with base-stacking of the nucleosides in the anticodon l
Cryptosporidiosis in persons with HIV infection.: Postgrad Med J. 1997 Nov;73(865):713-6. Unique Identifier : AIDSLINE MED/98179708; Ramratnam B; Flanigan TP; Miriam Hospital, Brown University School of Medicine, Providence, RI,; USA.; Cryptosporidium parvum is an ubiquitous protozoan parasite that is a major cause of diarrhoea in individuals infected with human immunodeficiency virus. The hallmarks of infection include profuse watery diarrhoea which may become chronic in the severely immunosuppressed individual. No uniformly effective therapy exist
Tissue disposition of zidovudine and its phosphorylated metabolites in zidovudine-treated healthy and retrovirus infected mice.: Pharm Res. 1998 Jan;15(1):139-44. Unique Identifier : AIDSLINE MED/98148541; Chow HH; Brookshier G; Li P; Department of Pharmacy Practice and Science, College of Pharmacy,; University of Arizona, Tucson 85721, USA. chow@pharmacy.arizona.edu; PURPOSE: The purpose of this study was to examine the effect of chronic AZT treatment on the in vivo tissue disposition of the phosphorylated AZT metabolites in healthy and retrovirus infected mice. METHODS: Female C57BL/6 mice at 12 weeks after inocu
Retroviruses and sexual size dimorphism in domestic cats (Felis catus L.).: Proc R Soc Lond B Biol Sci. 1998 Feb 7;265(1392):167-73. Unique Identifier : AIDSLINE MED/98154455; Pontier D; Fromont E; Courchamp F; Artois M; Yoccoz NG; UMR-CNRS 5558 'Biometrie, Genetique et Biologie des Populations,; Universite Claude Bernard Lyon 1, Villeurbanne, France.; dpontier@biomserv.univ-lyon1.fr; Hochberg and co-workers have predicted that an increase in host adult mortality due to parasites is balanced by an earlier age at first reproduction. In polygynous species we hypothesize that such a pattern would lead to diverging selection pressure on body size between sexes and increased sexual size dimorphism. In p
Dynamics of cytotoxic T-lymphocyte exhaustion.: Proc R Soc Lond B Biol Sci. 1998 Feb 7;265(1392):191-203. Unique Identifier : AIDSLINE MED/98154457; Wodarz D; Klenerman P; Nowak MA; University Hospital Zurich, Institute of Experimental Immunology,; Switzerland.; We examine simple mathematical models to investigate the circumstances under which the dynamics of cytotoxic T-lymphocyte CTL) activation and differentiation may result in the loss of virus specific CD8+ cells, a process known as CTL exhaustion. We distinguish between two general classes of viruses: (i) viruses infect
[HIV follow-up. New data on pathophysiology and treatment of psychiatric disturbances in the course of AIDS]: Psychiatr Pol. 1997 Mar-Apr;31(2):197-209. Unique Identifier : AIDSLINE MED/98061234; Nasierowski T; Matsumoto H; I Klinika Psychiatryczna AM w Warszawie.; In the article summarized here, the authors present the most important achievements in the research on pathogenesis and treatment of AIDS, with particular consideration of psychiatric disturbances occurring in the course of infection by AIDS. Since the 1 st of January 1993, a new definition of AIDS has been obligatory
[Psychiatric disorders and sensory deprivation in AIDS. Case report]: Psychiatr Pol. 1997 Mar-Apr;31(2):211-4. Unique Identifier : AIDSLINE MED/98061235; Nasierowski T; Kaminska-Kopicz E; I Klinika Psychiatryczna AM w Warszawie.; In AIDS there are several opportunistic infections that may occur. Some of them can lead to blindness (for example toxoplasmosis, CMV ). It is known that psychiatric disorders can also occur in AIDS. Both situations can take place at the same time. In that case w
Evaluation of serologic markers for transfusion transmitted infectious diseases for allogeneic blood donors in Puerto Rico.: P R Health Sci J. 1997 Sep;16(3):255-8. Unique Identifier : AIDSLINE MED/98093628; Martinez-Diaz H; Frye-Maldonado AC; Climent-Peris C; Velez-Rosario R; Department of Pathology, University of Puerto Rico.; The purpose of this project is to assess the prevalence of serologic markers for transfusion transmitted infectious disease in allogeneic blood donors of the American Red Cross Blood Services (ARCBS) in Puerto Rico . Four hundred records were randomly selected from a population
Pulmonary cryptococcoma with CD4 lymphocytopenia and meningitis in an HIV-negative patient.: Respir Med. 1998 Jan;92(1):120-2. Unique Identifier : AIDSLINE MED/98179760; Ho CL; Chang BC; Hsu GC; Wu CP; Department of Medicine, Tri-Service General Hospital, National Defense; Medical Center, Taipei, Taiwan, Republic of China.
[Multicentric Castleman's disease with mediastinal involvement in a patient with HIV infection]: Rev Mal Respir. 1997 Dec;14(6):481-3. Unique Identifier : AIDSLINE MED/98157692; Azoulay E; Herry I; Antoine M; Mayaud C; Cadranel J; Service de Pneumologie et Reanimation Respiratoire, Hopital Tenon,; Paris.; Castleman s disease is most often seen by a thoracic physician as a mediastinal tumour which is discovered fortuitously and whose surgical excision leads to a cure. We report a case of a patient of 30 who was seropositive for HIV and was suffering from Castleman s disease initially localised to the mediastinum. The di
[Manifestations, diagnosis and treatment of non-tuberculous mycobacterial infections in patients with HIV infection]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S142-51. Unique Identifier : AIDSLINE MED/98157684; Payen MC; De Wit S; Clumeck N; CHU Saint-Pierre, Bruxelles, Belgique.; The most frequent bacterial infections in patients infected with HIV and suffering from AIDS are non-tuberculous mycobacterial infections. Their incidence is increasing all the more as the survival of profoundly immunocompromised patients is prolonged. There are unknown factors as regards the precise origin of these i
[The natural history of tuberculosis infection and skin tuberculin reaction]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S27-32. Unique Identifier : AIDSLINE MED/98157674; Flament-Saillour M; Perronne C; Service des Maladies Infectieuses et Tropicales, Hopital; Raymond-Poincare, Garches.; Though most often asymptomatic, tuberculous infection induces a delayed hypersensitivity reaction in the host by activating cellular immunity thus rendering the host refractory, a priori , to a new infection; at least provided that the infecting dose is not massive or that the immune system of the host is not comprom
[The bacteriology of tuberculosis and non-tuberculosis mycobacterial infections]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S33-48. Unique Identifier : AIDSLINE MED/98157675; Wyplosz B; Truffot-Pernot C; Robert J; Jarlier V; Grosset J; Laboratoire Central de Bacteriologie, Groupe Hospitalier; Pitie-Salpetriere, Paris.; Changing incidence and nature of mycobacterial infections subsequent to the historical regression of tuberculosis and the acquired human immunodeficiency syndrome (AIDS) epidemic, as well as the development of new technical tools for molecular biology, have profoundly modified the methods used for the bacteriological
[Tuberculous infection and pulmonary tuberculosis in adults]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S49-59. Unique Identifier : AIDSLINE MED/98157676; Huchon G; Service de Pneumologie, Hopital Ambroise-Pare, Boulogne.; A tuberculous infection is the result of inhalation of tubercle bacilli either in great numbers or in subjects with diminished immunity. Clinical tuberculosis will only occur in 10 per cent of subjects following a first infection (primary tuberculosis) or subsequently (secondary tuberculosis or by a reactivation of a
[Pulmonary manifestations of tuberculosis in children]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S60-71. Unique Identifier : AIDSLINE MED/98157677; Olivier C; Service de Pediatrie Generale, Hopital Louis-Mourier, Colombes.; The occurrence of tuberculosis in children is dependent on a contagious bacillus carrying adult. Among 500 cases notified annually, perhaps 5 or 6% of the total infectious reservoir in France , 75% have parenchymal pulmonary disease and/or lymph nodes. These tuberculous diseases onl
[The epidemiology of tuberculosis and of the resistance to antitubercular agents]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S8-18. Unique Identifier : AIDSLINE MED/98157672; Ait Khaled N; Enarson D; Billo N; Union Internationale Contre la Tuberculose et les Maladies; Respiratoires (UICTMR), Paris.; Tuberculosis is once more a subject of world wide preoccupation; since 1985 a disturbing recrudescence of this disease has been noted in numerous countries related to population growth and the worsening of poverty in those countries without natural resources, and disadvantaged groups living on the margins of society i
[Antitubercular chemotherapy]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S88-104. Unique Identifier : AIDSLINE MED/98157679; Jouveshomme S; Dautzenberg B; Service de Pneumologie et Reanimation Respiratoire, Groupe Hospitalier; Pitie-Salpetriere, Paris.; Treatment of tuberculosis has three major goals: healing the patient, preventing selection of resistant strains and control transmission of tuberculosis. A 6 month regimen consisting of isoniazid, rifampin with addition of pyrazinamide for 2 months is the preferred treatment for pulmonary and extra-pulmonary tuberculo
Advances in HIV/AIDS statistical methodology over the past decade.: Stat Med. 1998 Jan 15;17(1):1-25. Unique Identifier : AIDSLINE MED/98125007; Foulkes MA; Division of AIDS, National Institute of Allergy and Infectious; Diseases, Bethesda, MD 20892, USA.; This review provides a synopsis of the developments over the past decade in mathematical and statistical methodology in response to the AIDS epidemic. This review includes highlights of the development of epidemic models, approaches to describing the natural history of HIV infection, and the methods developed for HIV
The use of simulation and bootstrap in information-based group sequential studies.: Stat Med. 1998 Jan 15;17(1):75-87. Unique Identifier : AIDSLINE MED/98125012; Scharfstein DO; Tsiatis AA; Department of Biostatistics, Johns Hopkins School of Public Health,; Baltimore, MD 21205-2179, USA.; In this paper, we present an information-based design and monitoring procedure which applies to any type of model for any type of group sequential study provided there is a unique parameter of interest one can estimate efficiently. Simulation techniques are described to handle the design phase of this procedure. Since
Nanolasers.: Sci Am. 1998 Mar;278(3):56-61. Unique Identifier : AIDSLINE MED/98148683; Gourley PL
Tuberculosis in England and Wales in 1993: results of a national survey. Public Health Laboratory Service/British Thoracic Society/Department of Health Collaborative Group.: Thorax. 1997 Dec;52(12):1060-7. Unique Identifier : AIDSLINE MED/98177544; Kumar D; Watson JM; Charlett A; Nicholas S; Darbyshire JH; PHLS Communicable Disease Surveillance Centre, London, UK.; BACKGROUND: A national survey of tuberculosis notifications in England and Wales was carried out in 1993 to determine the notification rate of tuberculosis and the trends in the occurrence of disease by ethnic group in comparison with the findings of similar surveys in 1978/79, 1983, and 1988. The prevalence of HIV in
Elevated free phenytoin and free valproic acid concentrations in sera of patients infected with human immunodeficiency virus.: Ther Drug Monit. 1998 Feb;20(1):63-7. Unique Identifier : AIDSLINE MED/98146505; Dasgupta A; McLemore JL; Department of Pathology and Laboratory Medicine, University of; Texas-Houston Health Science Center 77030, USA.; Seizures are common in patients infected with human immunodeficiency virus (HIV). Phenytoin and valproic acid are common anticonvulsants, and both drugs are strongly bound to serum albumin. Because patients infected with HIV are often on polytherapy, using homeopathic medicines, and may also have hypoalbuminemia, elev
[Acquired immunodeficiency syndrome in Moroccan children. A report of 8 cases]: Tunis Med. 1996 Jun-Jul;74(6-7):299-304. Unique Identifier : AIDSLINE MED/98166979; Lahbabi MS; Benomar S; Chaoui DM; Sqalli M; Service pediatrie 1 Hopital d'Enfant CHU Ibn Rochd Casablanca, Maroc.
[Novelties in tuberculosis]: Tunis Med. 1997 Dec;75(12):898-902. Unique Identifier : AIDSLINE MED/98168158; Bouacha H; Aouina H; Baccar MA; Azzabi S; Khirouni S; Lahidheb D
[Parvovirus B19--a cause of hepatitis in patients with liver transplantation, anemia in HIV positive individuals and encephalopathies in children]: Ugeskr Laeger. 1998 Mar 9;160(11):1653. Unique Identifier : AIDSLINE MED/98183145; Christensen LS; Hoiby N
Apoptotic killing of CD4+ T lymphocytes in HIV-1-infected PHA-stimulated PBL cultures is mediated by CD8+ LAK cells.: Virology. 1998 Feb 15;241(2):169-80. Unique Identifier : AIDSLINE MED/98160771; Wang L; Klimpel GR; Planas JM; Li H; Cloyd MW; Department of Pathology, University of Texas Medical Branch, Galveston; 77555-1019, USA.; In vitro infection of PHA-stimulated, normal CD4+ human peripheral blood T lymphocytes (PBLs) with several HIV-1 isolates did not result in cytopathology, despite high levels of virus replication and the fact that some of these isolates were cytopathic in certain cell lines. In contrast, infection of unfractionated PB
Differences in chemokine coreceptor usage between genetic subtypes of HIV-1.: Virology. 1998 Feb 15;241(2):181-8. Unique Identifier : AIDSLINE MED/98160772; Tscherning C; Alaeus A; Fredriksson R; Bjorndal A; Deng H; Littman DR; Fenyo EM; Albert J; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.; HIV-1 uses chemokine coreceptors for cell entry. CXCR4 is the major coreceptor for T-cell-line-adapted isolates and CCR5 for non-T-cell-line-adapted isolates. This study investigated if coreceptor usage differs between genetic subtypes of HIV-1. Eighty-one primary isolates representing nine different genetic subtypes
Persistent HTLV-I infection of breast luminal epithelial cells: a role in HTLV transmission?: Virology. 1998 Feb 15;241(2):200-14. Unique Identifier : AIDSLINE MED/98160774; Southern SO; Southern PJ; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA. sarka@lenti.med.umn.edu; Human T cell leukemia viruses are predominantly transmitted from mother to child by breastfeeding. Endemic levels of HTLV infection are associated with ethnic groups that have traditionally practised long-term breastfeeding. In the course of long-term lactation, we have found that human milk contains leukocytes and ep
Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems.: Virology. 1998 Feb 15;241(2):224-33. Unique Identifier : AIDSLINE MED/98160776; Luo T; Douglas JL; Livingston RL; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38105, USA.; Retroviruses have been extensively used in the development of gene transfer systems. Recently, there has been a great deal of interest in the use of lentiviruses for gene transfer because they infect nondividing cells. Human immunodeficiency virus (HIV) has been the lentivirus most often used for this purpose, but its
Chimeras containing influenza NS1 and HIV-1 Rev protein sequences: mechanism of their inhibition of nuclear export of Rev protein-RNA complexes.: Virology. 1998 Feb 15;241(2):234-50. Unique Identifier : AIDSLINE MED/98160777; Chen Z; Li Y; Krug RM; Department of Molecular Biology and Biochemistry, Rutgers University,; Piscataway, New Jersey 08855, USA.; Nuclear RNA export mediated by the HIV-1 Rev protein is inhibited by chimeric proteins in which the wild-type Rev protein is covalently linked to amino acid sequences of the NS1 protein of influenza A virus (NS1A protein), a protein that inhibits nuclear RNA export. These chimeric molecules function not only in cis bu
Evolution of human immunodeficiency virus type 1 envelope sequences in infected individuals with differing disease progression profiles.: Virology. 1998 Feb 15;241(2):251-9. Unique Identifier : AIDSLINE MED/98160778; Shankarappa R; Gupta P; Learn GH Jr; Rodrigo AG; Rinaldo CR Jr; Gorry MC; Mullins JI; Nara PL; Ehrlich GD; Department of Pathology, University of Pittsburgh, Pennsylvania 15261,; USA.; Sequence variation displayed by the human immunodeficiency virus type 1 (HIV-1) has been proposed to be linked to the pathogenesis of acquired immunodeficiency syndrome (AIDS). To assess viral evolution during the course of infection, we evaluated sequence variability in the env variable domains in four HIV-1-infected
Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS.: Virology. 1998 Feb 15;241(2):260-8. Unique Identifier : AIDSLINE MED/98160779; Green KA; Noelle RJ; Green WR; Department of Microbiology, Dartmouth Medical School, Lebanon, New; Hampshire 03756, USA.; In genetically susceptible C57BL/6 mice the LP-BM5 isolate of murine retroviruses causes profound splenomegaly, lymphadenopathy, hypergammaglobulinemia, and an immunodeficiency syndrome bearing many similarities to the pathologies seen in AIDS. Because of these similarities, which also include terminal B cell lymphoma
Characterization of the cytotoxic factor(s) released from thymic dendritic cells upon human immunodeficiency virus type 1 infection.: Virology. 1998 Feb 15;241(2):285-97. Unique Identifier : AIDSLINE MED/98160782; Beaulieu S; Lafontaine M; Richer M; Courchesne I; Cohen EA; Bergeron D; Departement de Microbiologie et Immunologie, Universite de Montreal,; Succursale Centre-ville, Quebec, Canada.; We previously demonstrated that infection of primary human thymic dendritic cells (DCs) with laboratory strains of HIV leads to the release of soluble factor(s) which induced thymocyte killing. In the present paper, we extend the characterization of this process. Our results reveal that primary HIV-1 isolates are simi
Human T-cell leukemia virus type 1 Tax protein induces the expression of lymphocyte chemoattractant SDF-1/PBSF.: Virology. 1998 Feb 15;241(2):298-303. Unique Identifier : AIDSLINE MED/98160783; Arai M; Ohashi T; Tsukahara T; Murakami T; Hori T; Uchiyama T; Yamamoto N; Kannagi M; Fujii M; Department of Immunotherapeutics, Tokyo Medical and Dental University,; Japan.; We investigated the mechanism of lymphocyte infiltration into tissues infected with human T-cell leukemia virus type 1 HTLV-1). The cytokine SDF-1/PBSF is a highly efficient chemoattractant for lymphocytes. Reverse transcription-PCR analysis showed that among various human T-cell lines, those infected with HTLV-1 sele
Glomerular lesions in HIV-infected patients: a Yale University Department of Medicine Residency Peer-Teaching Conference.: Yale J Biol Med. 1997 Mar-Apr;70(2):161-73. Unique Identifier : AIDSLINE MED/98152867; Wrone EM; Carey H; Reilly RF; Department of Medicine, Yale University School of Medicine, New Haven,; Connecticut, USA.; HIV-associated nephropathy (HIVAN) is a clinicopathologic entity characterized by heavy proteinuria, absence of edema and an irreversible decline in renal function. Findings on renal biopsy include: collapsed glomerular capillaries; visceral glomerular epitheliosis; microcystic tubules; mesangial prominence; and endot
[Morphological study of Enterocytozoon bineousi in patients with AIDS and chronic diarrhea]: Acta Gastroenterol Latinoam. 1997;27(4):241-5. Unique Identifier : AIDSLINE MED/98064170; Velasquez JN; Di Risio C; Carnevale S; Corti M; Benetucci J; Bossini JP; Cabrera M; Chertcoff A; Labbe JH; Rodriguez M; Bessaso H; Guarnera EA; Departamento de Parasitologia, Instituto Nacional de Microbiologia Dr.; Carlos G. Malbran, Buenos Aires, Argentina.; Microsporidia are protozoan parasites responsible for significant gastrointestinal disease in patients infected with the human immunodeficiency virus. We report the clinical features of three patients with chronic diarrhea and intestinal microsporidiosis caused by Ente
The effects of human immunodeficiency virus in the central nervous system.: Adv Virus Res. 1998;50:1-47. Unique Identifier : AIDSLINE MED/98181623; Kolson DL; Lavi E; Gonzalez-Scarano F; Department of Neurology and Microbiology, University of Pennsylvania; School of Medicine, Philadelphia 19104-6146, USA.; More than a decade after the first description of HIV DNA in the nervous system the pathophysiology of HIVD remains largely enigmatic, with data supporting a number of potential mechanisms for the development of neuronal dysfunction. Nevertheless, a few key findings have considerable support in the literature devoted
Pathogenesis of AIDS-related lymphomas: molecular and histogenetic heterogeneity.: Am J Pathol. 1998 Mar;152(3):623-30. Unique Identifier : AIDSLINE MED/98161506; Gaidano G; Carbone A; Dalla-Favera R; Division of Internal Medicine, University of Torino at Novara, Italy.
Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis.: Am J Pathol. 1998 Mar;152(3):659-65. Unique Identifier : AIDSLINE MED/98161511; Westmoreland SV; Rottman JB; Williams KC; Lackner AA; Sasseville VG; Division of Comparative Pathology, New England Regional Primate; Research Center, Harvard Medical School, Southborough, Massachusetts; 01772-9102, USA.; Although the mechanisms of human immunodeficiency virus (HIV) neuroinvasion, neuronal injury, and subsequent development of HIV-1-associated AIDS dementia complex are not fully understood, a correlation between monocyte/macrophage infiltrates in the brain and neurological disease e
Detection of HTLV-1 by polymerase chain reaction in situ hybridization in adult T-cell leukemia/lymphoma.: Am J Pathol. 1998 Mar;152(3):683-9. Unique Identifier : AIDSLINE MED/98161515; Setoyama M; Kerdel FA; Elgart G; Kanzaki T; Byrnes JJ; Department of Dermatology, Kagoshima University Faculty of Medicine,; Sakuragaoka, Japan. setoyama@med5.kufm.kagoshima-u.ac.jp; A method for nonradioactive polymerase chain reaction in situ hybridization was developed and used to determine the distribution of human T-lymphotropic virus type I (HTLV-I) proviral DNA in paraffin-embedded surgical specimens of adult T-cell leukemia/lymphoma (ATLL). As controls, we used biopsy samples of five cases
Randomized, placebo-controlled trial of paroxetine versus imipramine in depressed HIV-positive outpatients.: Am J Psychiatry. 1998 Mar;155(3):367-72. Unique Identifier : AIDSLINE MED/98162368; Elliott AJ; Uldall KK; Bergam K; Russo J; Claypoole K; Roy-Byrne PP; Department of Psychiatry and Behavioral Sciences, University of; Washington, Seattle 98104, USA. aelliott@u.washington.edu; OBJECTIVE: This study examined whether a selective serotonin reuptake inhibitor (paroxetine) had comparable efficacy but greater tolerability than a tricyclic antidepressant (imipramine) in depressed patients with HIV infection. METHOD: Seventy-five HIV-positive patients (45% of whom had AIDS) were blindly and randoml
[Free radicals and HIV infection]: Ann Biol Clin (Paris). 1997 Nov-Dec;55(6):565-71. Unique Identifier : AIDSLINE MED/98160896; Rabaud C; Tronel H; Fremont S; May T; Canton P; Nicolas JP; Service de maladies infectieuses et tropicales, CHU de Nancy, Hopitaux; de Brabois, Vandoeuvre-les-Nancy.; In HIV infected patients, the increase of the concentration of free radicals is related to: a depletion of protective system glutathione peroxidase, superoxide dismutase, vitamin E, selenium ...), and an increased production of free radicals superoxide anion, hydrogen peroxide, hydroxil radical) consecutive to the act
Effect of fluconazole on indinavir pharmacokinetics in human immunodeficiency virus-infected patients.: Antimicrob Agents Chemother. 1998 Feb;42(2):223-7. Unique Identifier : AIDSLINE MED/98139004; De Wit S; Debier M; De Smet M; McCrea J; Stone J; Carides A; Matthews C; Deutsch P; Clumeck N; Division of Infectious Diseases, C.H.U. Saint-Pierre, Brussels,; Belgium.; To evaluate a potential pharmacokinetic interaction of coadministration of fluconazole, and indinavir, a human immunodeficiency virus (HIV) protease inhibitor, 13 patients were enrolled in a multiple-dose, three-period, placebo-controlled, crossover study. Patients were randomly assigned to receive indinavir at 1,000
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents.: Antimicrob Agents Chemother. 1998 Feb;42(2):241-53. Unique Identifier : AIDSLINE MED/98139008; Sanglard D; Ischer F; Koymans L; Bille J; Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois,; Lausanne, Switzerland. dsanglar@eliot.unil.ch; The cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) of yeasts is involved in an important step in the biosynthesis of ergosterol. Since CYP51A1 is the target of azole antifungal agents, this enzyme is potentially prone to alterations leading to resistance to these agents. Among them, a decrease in the affini
A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs.: Antimicrob Agents Chemother. 1998 Feb;42(2):269-76. Unique Identifier : AIDSLINE MED/98139012; Hertogs K; de Bethune MP; Miller V; Ivens T; Schel P; Van Cauwenberge A; Van Den Eynde C; Van Gerwen V; Azijn H; Van Houtte M; Peeters F; Staszewski S; Conant M; Bloor S; Kemp S; Larder B; Pauwels R; VIRCO, Central Virological Laboratory, Edegem, Belgium.; kurt.hertogs@virco.be; Combination therapy with protease (PR) and reverse transcriptase RT) inhibitors can efficiently suppress human immunodeficiency virus (HIV) replication, but the emergence of drug-resistant variants correlates strongly with therapeutic failure. Here we describe a new method for high-throughput analysis of clinical samp
Pharmacokinetics and absolute bioavailability of oral foscarnet in human immunodeficiency virus-seropositive patients.: Antimicrob Agents Chemother. 1998 Feb;42(2):293-7. Unique Identifier : AIDSLINE MED/98139016; Noormohamed FH; Youle MS; Higgs CJ; Martin-Munley S; Gazzard BG; Lant AF; Department of Clinical Pharmacology and Therapeutics, Imperial College; School of Medicine, Chelsea and Westminster Hospital, London, United; Kingdom. f.noormohamed@lc.ac.uk; The pharmacokinetics, absolute bioavailability, accumulation, and tolerability over 8 days of an oral formulation of foscarnet (90 mg/kg of body weight once daily [QD] [n = 6], 90 mg/kg twice daily [BID] [n = 6], and 180 mg/kg QD [n = 31) were investigated in 15 asymptomatic, human immunodeficiency virus-seropositive
Single-dose pharmacokinetics of indinavir and the effect of food.: Antimicrob Agents Chemother. 1998 Feb;42(2):332-8. Unique Identifier : AIDSLINE MED/98139022; Yeh KC; Deutsch PJ; Haddix H; Hesney M; Hoagland V; Ju WD; Justice SJ; Osborne B; Sterrett AT; Stone JA; Woolf E; Waldman S; Merck Research Laboratories, West Point, Pennsylvania 19486, USA.; kuang_yeh@merck.com; Indinavir sulfate is a human immunodeficiency virus type 1 HIV-1) protease inhibitor indicated for treatment of HIV infection and AIDS in adults. The purpose of this report is to summarize single-dose studies which characterized the pharmacokinetics o
Mathematical modeling of the interrelationship of CD4 lymphocyte count and viral load changes induced by the protease inhibitor indinavir.: Antimicrob Agents Chemother. 1998 Feb;42(2):358-61. Unique Identifier : AIDSLINE MED/98139027; Drusano GL; Stein DS; Department of Medicine, Albany Medical College, New York 12208, USA.; GLDrusano@aol.com; While CD4 cell counts are widely used to predict disease progression in human immunodeficiency virus (HIV)-infected patients, they are poorly explanatory of the progression to AIDS or death after the introduction of chemotherapy. Changes in HIV load (as measured by RNA PCR) have been shown to be a much better predicto
TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus.: Antimicrob Agents Chemother. 1998 Feb;42(2):383-8. Unique Identifier : AIDSLINE MED/98139031; Uckun FM; Chelstrom LM; Tuel-Ahlgren L; Dibirdik I; Irvin JD; Langlie MC; Myers DE; Wayne Hughes Institute, St. Paul, Minnesota 55113, USA.; faith_uckun@mercury.ih.org; We have evaluated the clinical potential of TXU anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-sev
Zalcitabine population pharmacokinetics: application of radioimmunoassay.: Antimicrob Agents Chemother. 1998 Feb;42(2):409-13. Unique Identifier : AIDSLINE MED/98139036; Adams JM; Shelton MJ; Hewitt RG; DeRemer M; DiFrancesco R; Grasela TH; Morse GD; Department of Pharmacy Practice, State University of New York at; Buffalo, Amherst 14260, USA.; Zalcitabine population pharmacokinetics were evaluated in 44 human immunodeficiency virus-infected patients (39 males and 5 females) in our immunodeficiency clinic. Eighty-one blood samples were collected during routine clinic visits for the measurement of plasma zalcitabine concentrations by radioimmunoassay 1.84+/-1
The Cys607-->Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients.: Antimicrob Agents Chemother. 1998 Feb;42(2):444-6. Unique Identifier : AIDSLINE MED/98139045; Baldanti F; Underwood MR; Talarico CL; Simoncini L; Sarasini A; Biron KK; Gerna G; Servizio di Virologia, IRCCS Policlinico S. Matteo, Pavia, Italy.; Two ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strains recovered from an AIDS patient (strain VR4990) and a heart transplant recipient (strain VR5474) showed a Cys607-->Tyr change in the UL97-encoded phosphotransferase. No amino acid substitutions were observed in the
A mutation at position 190 of human immunodeficiency virus type 1 reverse transcriptase interacts with mutations at positions 74 and 75 via the template primer.: Antimicrob Agents Chemother. 1998 Feb;42(2):447-52. Unique Identifier : AIDSLINE MED/98139046; Boyer PL; Gao HQ; Hughes SH; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Maryland 21702-1201, USA.; We have analyzed amino acid substitutions at position G190 in the reverse transcriptase (RT) of human immunodeficiency virus type 1 HIV-1). The mutation G190E, which is responsible for resistance to certain nonnucleoside inhibitors, results in RT that has significantly less polymerase activity and that is less process
Estimate of the frequency of human immunodeficiency virus type 1 protease inhibitor resistance within unselected virus populations in vitro.: Antimicrob Agents Chemother. 1998 Feb;42(2):478-80. Unique Identifier : AIDSLINE MED/98139056; Tucker SP; Stiebel TR Jr; Potts KE; Smidt ML; Bryant ML; G. D. Searle, Searle Research and Development, St. Louis, Missouri; 63198, USA. simon.t@biota.com.au; The frequency of drug-resistant human immunodeficiency virus type 1 (HIV-1) variants in virus populations not previously exposed to drug was determined in vitro by using HIV-1RF and the protease inhibitor SC-55389A. Two variants with single mutations responsible for drug resistance (V82A and N88S) were quantifiably is
Prevalence of parvovirus B19 infection among patients with human immunodeficiency virus infection in Barcelona, Spain [letter]: Arch Intern Med. 1998 Mar 23;158(6):680-1. Unique Identifier : AIDSLINE MED/98180532; Negredo E; Domingo P; Rabella N; Lopez-Contreras J; Fontanet A; Orellana I
Human immunodeficiency virus sexual risk reduction in homeless men with mental illness.: Arch Gen Psychiatry. 1998 Mar;55(3):266-72. Unique Identifier : AIDSLINE MED/98169040; Susser E; Valencia E; Berkman A; Sohler N; Conover S; Torres J; Betne P; Felix A; Miller S; Department of Psychiatry, Columbia University School of Medicine, New; York State Psychiatric Institute, New York 10032, USA.; BACKGROUND: The spread of human immunodeficiency virus infection to impaired groups has intensified the challenge for its prevention; control of the epidemic now requires behavioral change among persons with limited ability to sustain attention and learn. In this randomized clinical trial, we tested an intervention to
Characterization of an integrase mutant of feline immunodeficiency virus.: Arch Virol. 1998;143(1):1-14. Unique Identifier : AIDSLINE MED/98166861; Tomonaga K; Itagaki SI; Kashiwase H; Kawaguchi Y; Inoshima Y; Ikeda Y; Mikami T; Department of Veterinary Microbiology, University of Tokyo, Japan.; The role of the integrase region of feline immunodeficiency virus FIV) in viral replication was examined using an integrase mutant clone of FIV which carries a frameshift mutation in the region. Upon transfection, although the integrase mutant was able to release virus-like particles into the supernatant from the tran
Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E.: Arch Virol. 1998;143(1):157-62. Unique Identifier : AIDSLINE MED/98166873; Inoshima Y; Miyazawa T; Kohmoto M; Ikeda Y; Sato E; Hohdatsu T; Mathiason-Dubard C; Hoover EA; Mikami T; Department of Veterinary Microbiology, Graduate School of Agricultural; and Life Sciences, University of Tokyo, Japan.; Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV gen
Detection of bovine immunodeficiency-like virus infection in experimentally infected calves.: Arch Virol. 1998;143(1):181-9. Unique Identifier : AIDSLINE MED/98166876; Baron T; Betemps D; Mallet F; Cheynet V; Levy D; Belli P; Centre National d'Etudes Veterinaires et Alimentaires, Lyon, France.; Detection of BIV virus infection by serological means, PCR and virus isolation in experimentally infected calves is described. Viral sequences were specifically detected by PCR in peripheral blood mononuclear cells (PBMCs), with primer systems located in the gag, pol and tat regions of the viral genome. An enzyme-link
Construction and characterization of a stably transformed HeLa cell line in which the expression of bovine herpesvirus 1 ICP0 BICP0) is induced by tetracycline.: Arch Virol. 1998;143(1):35-48. Unique Identifier : AIDSLINE MED/98166864; Steinmann NA; Nunez R; Koppel R; Ackermann M; Institute of Virology, University of Zurich, Switzerland.; To explore the effects BICP0 (a principal transactivator of BHV-1 gene expression) on viral promoter elements, we established a cell line in which the expression of BICP0 is regulated by tetracycline. A hybrid promoter containing reiterated copies of the tet-operator (tet-O) and a minimal herpesviral alpha gene transi
Facilitation of HIV-1 isolation from patients by neuraminidase.: Arch Virol. 1998;143(1):85-95. Unique Identifier : AIDSLINE MED/98166868; Xin X; Shioda T; Fukushima M; Hu H; Oka S; Iwamoto A; Nagai Y; Department of Viral Infection, University of Tokyo, Japan.; We previously reported that infectivities of human and other non-human lentiviruses including human immunodeficiency virus type 1 (HIV-1) are activated by desialylation of the virion surface [H. Hu et al., J Virol 70: 7,462-7,470 (1996)]. The present study was designed to determine whether neuraminidase NA) is useful
All-trans retinoic acid potentiates the ability of interferon beta-1b to augment suppressor cell function in multiple sclerosis.: Arch Neurol. 1998 Mar;55(3):315-21. Unique Identifier : AIDSLINE MED/98178827; Qu ZX; Dayal A; Jensen MA; Arnason BG; Department of Neurology and the Brain Research Institute, University; of Chicago, Ill 60637, USA.; OBJECTIVE: To determine the effects of combination all-trans retinoic acid (RA) and interferon beta-1b therapy on immune system functions potentially relevant to multiple sclerosis (MS). DESIGN: Interferon gamma-secreting cells, T suppressor cell function, and lymphocyte proliferative responses were assayed using peri
Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection.: Biochem Biophys Res Commun. 1998 Feb 13;243(2):497-502. Unique Identifier : AIDSLINE MED/98153793; Jinno A; Shimizu N; Soda Y; Haraguchi Y; Kitamura T; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Japan.; We have isolated HIV-1 variants that infect brain-derived CD4-positive cells, which are resistant to both macrophage M)-tropic and T-cell line (T)-tropic HIV-1 strains. It is possible that this brain cell tropism of the HIV-1 variants is determined by the interaction of HIV-1 with a chemokine receptor CKR) gene. We at
Design of carrier peptide-oligonucleotide conjugates with rapid membrane translocation and nuclear localization properties.: Biochem Biophys Res Commun. 1998 Feb 13;243(2):601-8. Unique Identifier : AIDSLINE MED/98153811; Chaloin L; Vidal P; Lory P; Mery J; Lautredou N; Divita G; Heitz F; Centre de Recherche de Biochimie Macromoleculaire, ERS 155 1919,; Montpellier, France.; Peptides containing a hydrophobic motif associated with a nuclear localization signal separated by various linkers were synthesized in solid phase. The hydrophobic sequence corresponds either to a signal peptide sequence or to a fragment of the fusion peptide of GP41 while the hydrophilic sequence is that of a nuclear
Congenital malaria in a preterm neonate: case report and review of the literature.: Am J Perinatol. 1998 Jan;15(1):19-22. Unique Identifier : AIDSLINE MED/98133829; Ahmed A; Cerilli LA; Sanchez PJ; Department of Pediatrics, The University of Texas Southwestern Medical; Center at Dallas, 75235-9063, USA.; Congenital malaria occurs infrequently in endemic areas and is even more uncommon in the United States . Although more than 300 cases of congenital malaria have been reported, only four reports describing this disease in preterm infants exist in the English-language literature. We repor
Are medical students ready to provide HIV-prevention counseling?: Acad Med. 1998 Mar;73(3):342-6. Unique Identifier : AIDSLINE MED/98187212; Cook RL; Steiner BD; Smith AC 3rd; Evans AT; Willis SE; Petrusa ER; Harward DH; Richards BF; University of Pittsburgh Center for Research on Health Care, PA, USA.; cookr@genmed.upmc.edu; PURPOSE: To determine whether medical students were prepared to assess risk and counsel patients about prevention of HIV infection, and whether HIV-related experience produced better knowledge and counseling skills. METHOD: In 1995, students at four North Carolina medical schools interviewed a standardized patient por
Correlation of in vitro T-cell and B-cell function with responses to childhood vaccines in children with human immunodeficiency virus infection.: Viral Immunol. 1997;10(4):197-206. Unique Identifier : AIDSLINE MED/98132492; Peters VB; Mayer LF; Sperber KE; Department of Pediatrics, Mount Sinai School of Medicine, New York,; New York 10029, USA.; We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacci
Changes in CD8 cell subpopulations induced by antiretroviral therapy in human immunodeficiency virus infected patients.: Viral Immunol. 1997;10(4):207-12. Unique Identifier : AIDSLINE MED/98132493; Silvestri G; Munoz C; Butini L; Bagnarelli P; Montroni M; Service of Clinical Immunology, Department of Internal Medicine,; University of Ancona Medical School, Italy.; Although CD4+ T cells are the main target of HIV infection, CD8+ cells also play important roles in the interaction between HIV and the host immune system. The aim of this study was to analyze the effect of anti-HIV therapy on the relative proportion of some important CD8+ cell subpopulations. Five HIV-infected patien
Cross-clade immune responses after immunization with a whole-killed gp120-depleted human immunodeficiency virus type-1 immunogen in incomplete Freund's adjuvant (HIV-1 immunogen, REMUNE) in human immunodeficiency virus type-1 seropositive subjects.: Viral Immunol. 1997;10(4):221-8. Unique Identifier : AIDSLINE MED/98132495; Moss RB; Giermakowska W; Lanza P; Turner JL; Wallace MR; Jensen FC; Theofan G; Richieri SP; Carlo DJ; Immune Response Corporation, Carlsbad, California 92008, USA.; Lymphocyte proliferation responses to gp120-depleted HZ321 virus clade A) antigen were compared to BAL human immunodeficiency virus (HIV) virus antigen (clade B) responses, clade E HIV virus antigen responses, and purified native p24 antigen responses in 15 human immunodeficiency virus type-1 (HIV-1) seropositive subj
Letters to loved ones: please don't bring HIV home.: World Health Forum. 1997;18(3-4):311-8. Unique Identifier : AIDSLINE MED/98138634; Stam K; Elkins DB; Dole LR; Somboonsuk B; Multisectoral AIDS Prevention Strategy, North-East Centre for AIDS; Prevention and Care, Khon Kaen University, Thailand.
HIV/AIDS: the global epidemic [news]: World Health Forum. 1997;18(3-4):369-72. Unique Identifier : AIDSLINE MED/98138651
Trends in HIV seropositivity in publicly funded HIV counseling and testing programs: implications for prevention policy.: Am J Prev Med. 1998 Jan;14(1):31-42. Unique Identifier : AIDSLINE MED/98135701; Valdiserri RO; Weber JT; Frey R; Centers for Disease Control and Prevention, Atlanta, Georgia 30333,; USA.; INTRODUCTION: We describe trends in seropositivity among clients attending publicly funded HIV counseling and testing sites across the United States and discuss implications for prevention policy. METHODS: The present analysis used client-level data from 1990 through 1994 for 26 of 65
The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine.: Int Immunol. 1998 Jan;10(1):17-25. Unique Identifier : AIDSLINE MED/98147476; Al-Qaoud KM; Fleischer B; Hoerauf A; Department of Immunology, Bernhard Nocht Institute for Tropical; Medicine, Hamburg, Germany.; The pathways conferring immunity to filarial infections are not well known, in part because human pathogenic filariae do not develop a full infection cycle in laboratory mice. Using the permissive infection with Litomosoides sigmodontis in BALB/c mice, we have shown previously that worm development is controlled by CD
Defective co-stimulation and impaired Th1 development in tumor necrosis factor/lymphotoxin-alpha double-deficient mice infected with Candida albicans.: Int Immunol. 1998 Jan;10(1):37-48. Unique Identifier : AIDSLINE MED/98147478; Mencacci A; Cenci E; Del Sero G; Fe d'Ostiani C; Mosci P; Montagnoli C; Bacci A; Bistoni F; Quesniaux VF; Ryffel B; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.; To define the immunological functions of tumor necrosis factor TNF) in Candida albicans infection, TNF/lymphotoxin (LT)-alpha double-deficient mice were assessed for susceptibility to systemic or gastrointestinal infection and parameters of innate and adaptive Th immunity. When compared to wild-type mice, TNF/LT-alpha
H2M3wt-restricted, Listeria monocytogenes-immune CD8 T cells respond to multiple formylated peptides and to a variety of gram-positive and gram-negative bacteria.: Int Immunol. 1998 Jan;10(1):7-15. Unique Identifier : AIDSLINE MED/98147475; Nataraj C; Huffman GR; Kurlander RJ; Department of Medicine, Duke University Medical Center, Durham, NC; 27710, USA.; A subset of H2M3wt-restricted, Listeria monocytogenes (LM)-immune CD8 effectors recognize antigen-presenting cells (APC) preincubated with heat-killed LM. The responsible product, which we have previously designated heat-killed Listeria-associated antigen (HAA), is extremely hydrophobic and resistant to proteolytic de
Complement-mediated cytolysis and azidothymidine are synergistic in HIV-1 suppression.: Int Immunol. 1998 Jan;10(1):91-5. Unique Identifier : AIDSLINE MED/98147483; Okada H; Wu X; Okada N; Department of Molecular Biology, Nagoya City University School of; Medicine, Nagoya, Japan.; Some normal human sera contain a natural IgM antibody against gangliotetraose and GM2 which is capable of initiating complement-mediated cytolysis of HIV-1-infected cells. A potent cytolytic serum (lytic serum) harboring this antibody also caused lysis of HIV-1 virions. When lytic serum was added to a mixed culture of
Time-resolved fluorescence anisotropy of HIV-1 protease inhibitor complexes correlates with inhibitory activity.: Biochemistry. 1998 Mar 3;37(9):2778-86. Unique Identifier : AIDSLINE MED/98153161; Kungl AJ; Visser NV; van Hoek A; Visser AJ; Billich A; Schilk A; Gstach H; Auer M; Department of Immunology, Novartis Forschungsinstitut, Brunnerstrasse; 59, A-1235 Wien, Austria. andreas.kungl@pharma.novartis.com; The tryptophan time-resolved fluorescence intensity and anisotropy of the HIV-1 protease dimer is shown to be a quick and efficient method for the conformational characterization of protease inhibitor complexes. Four fluorescence lifetimes were needed to adequately describe the fluorescence decay of the two tryptophan
Site-specific cross-linking of amino acids in the basic region of human immunodeficiency virus type 1 Tat peptide to chemically modified TAR RNA duplexes.: Biochemistry. 1998 Mar 3;37(9):3096-108. Unique Identifier : AIDSLINE MED/98153196; Farrow MA; Aboul-ela F; Owen D; Karpeisky A; Beigelman L; Gait MJ; Laboratory of Molecular Biology, Medical Research Council, Hills Road,; Cambridge CB2 2QH, U.K.; The Human Immunodeficiency Virus type 1 Tat protein interacts specifically with a U-rich bulge within an RNA stem-loop known as the trans-activation responsive region (TAR) that occurs in all viral transcripts. We have photochemically cross-linked to Tat peptide (37-72), a model TAR duplex substituted at U23 in the bu
Performance of Massachusetts HMOs in providing Pap smear and sexually transmitted disease screening to adolescent females.: J Adolesc Health. 1998 Mar;22(3):184-9. Unique Identifier : AIDSLINE MED/98162735; Thrall JS; McCloskey L; Spivak H; Ettner SL; Tighe JE; Emans SJ; Alliance for Young Families, Boston, MA 02108, USA.; PURPOSE: To describe the extent to which health maintenance organizations (HMOs) provide preventive health services to female adolescent enrollees. METHODS: All Massachusetts HMOs were asked to provide 1992 Papanicolaou (Pap) smear, gonorrhea, chlamydia, syphilis, and human immunodeficiency virus test rates for adoles
Primary care of patients infected with human immunodeficiency virus.: Clin Infect Dis. 1998 Feb;26(2):275-6. Unique Identifier : AIDSLINE MED/98161544; Sexton DJ; Band J; Berman S; Bradley J; Dalovisio JR; Ingram C; Joseph WP; Petrak RM; Slama TG; Wade BH; Duke University Medical Center, Durham, North Carolina 27710, USA.
Career opportunities for infectious diseases subspecialists.: Clin Infect Dis. 1998 Feb;26(2):277-81. Unique Identifier : AIDSLINE MED/98161545; Preheim LC; Section of Infectious Diseases, Creighton University School of; Medicine, University of Nebraska Medical Center, and Veterans Affairs; Medical Center, Omaha 68105, USA.; Few data are available regarding trends in career opportunities for subspecialty physicians. A review of advertisements for infectious diseases physicians in the 1990, 1993, and 1995 issues of the New England Journal of Medicine revealed a significant decline in the number of openings between 1990 and 1995. In each ye
Cryptococcal meningitis in human immunodeficiency virus-infected patients in Harare, Zimbabwe.: Clin Infect Dis. 1998 Feb;26(2):284-9. Unique Identifier : AIDSLINE MED/98161548; Heyderman RS; Gangaidzo IT; Hakim JG; Mielke J; Taziwa A; Musvaire P; Robertson VJ; Mason PR; Department of Medicine, Medical School, University of Zimbabwe,; Harare.; A prospective observational study was conducted over a 10-month period to determine the clinical and laboratory manifestations of cryptococcal meningitis in Zimbabwe , a country where antifungal agents are not widely available. Eighty-nine patients with cryptococcal meningitis (me
Fatal Mycobacterium tuberculosis bloodstream infections in febrile hospitalized adults in Dar es Salaam, Tanzania.: Clin Infect Dis. 1998 Feb;26(2):290-6. Unique Identifier : AIDSLINE MED/98161549; Archibald LK; den Dulk MO; Pallangyo KJ; Reller LB; Department of Pathology, Duke University School of Medicine, Durham,; North Carolina, USA.; Causes of community-acquired bloodstream infections (BSIs) in sub-Saharan Africa are unknown with regard to mycobacteria and fungi. We prospectively studied 517 consecutive febrile (axillary temperature, > or =37.5 degrees C) adults (> or =15 years of age) admitted to one hospital in
Severity and prognosis of acute human immunodeficiency virus type 1 illness: a dose-response relationship.: Clin Infect Dis. 1998 Feb;26(2):323-9. Unique Identifier : AIDSLINE MED/98161554; Vanhems P; Lambert J; Cooper DA; Perrin L; Carr A; Hirschel B; Vizzard J; Kinloch-de Loes S; Allard R; Hotel-Dieu de Montreal, and the Department of Social and Preventive; Medicine, University of Montreal, Quebec, Canada.; This study examined the relationship between the severity of acute human immunodeficiency virus type 1 (HIV-1) illness and disease progression and death. The population included 218 patients with acute HIV-1 illness and 41 asymptomatic patients who underwent HIV-1 seroconversion; the patients were followed up prospect
Prevalence and clinical significance of intestinal microsporidiosis in human immunodeficiency virus-infected patients with and without diarrhea in Germany: a prospective coprodiagnostic study.: Clin Infect Dis. 1998 Feb;26(2):475-80. Unique Identifier : AIDSLINE MED/98161579; Sobottka I; Schwartz DA; Schottelius J; Visvesvara GS; Pieniazek NJ; Schmetz C; Kock NP; Laufs R; Albrecht H; Department of Internal Medicine, University Hospital Eppendorf,; Germany.; The prevalence of intestinal microsporidiosis among human immunodefiency virus (HIV)-infected persons with chronic diarrhea varies from 7% to 50%; thus, microsporidia are a significant source of morbidity and, occasionally, mortality among these patients. Anecdotal rep
Tuberculosis among refugees and displaced people at the Burundi-Rwanda border.: Clin Infect Dis. 1998 Feb;26(2):500-1. Unique Identifier : AIDSLINE MED/98161587; Di Perri G; Cazzadori A; Vento S; Allegranzi B; Nardi S; Brunello F; Bonora S; Concia E; Institute of Immunology and Infectious Diseases, Division of; Pneumology, University of Verona, Italy.
Facial folliculitis due to Clostridium perfringens in a patient infected with human immunodeficiency virus.: Clin Infect Dis. 1998 Feb;26(2):501-2. Unique Identifier : AIDSLINE MED/98161588; Caumes E; Mommeja-Marin H; Chosidow O; Jouan M; Nguyen J; Bricaire F; Service des Maladies Infectieuses et Tropicales, Hopital de la; Pitie-Salpetriere, Paris, France.
Detection of human papillomavirus type 35 in a nodular cutaneous tumor in a patient infected with human immunodeficiency virus.: Clin Infect Dis. 1998 Feb;26(2):507-8. Unique Identifier : AIDSLINE MED/98161592; Meyer T; Kunz M; Arndt R; Meigel W; Stoer A; Plettenberg A; Institute of Immunology, Pathology, and Molecular Biology and; Department of Dermatology, St. Georg Hospital, Hamburg, Germany.
Persistence of Pneumocystis carinii after effective treatment of P. carinii pneumonia is not related to relapse or survival among patients infected with human immunodeficiency virus.: Clin Infect Dis. 1998 Feb;26(2):509-10. Unique Identifier : AIDSLINE MED/98161593; Roger PM; Vandenbos F; Pugliese P; De Salvador F; Durant J; Le Fichoux Y; Dellamonica P; Centre Hospitalier Universitaire, Infectious Diseases and Tropical; Medicine Department, Hopital de l'Archet I, Nice, France.
Facet and facet-joint infections: case report and review.: Clin Infect Dis. 1998 Feb;26(2):510-2. Unique Identifier : AIDSLINE MED/98161594; Louie T; Morgan B; Standiford HC; Department of Medicine, Veterans Affairs Medical Center, Baltimore,; Maryland, USA.
AIDS-related herpes simplex virus encephalitis during maintenance foscarnet therapy.: Clin Infect Dis. 1998 Feb;26(2):513-4. Unique Identifier : AIDSLINE MED/98161596; Read RC; Vilar FJ; Smith TL; Division of Molecular and Genetic Medicine, University of Sheffield; Medical School, Royal Hallamshire Hospital, United Kingdom.; r.c.read@sheffield.ac.uk
Severe allergic reaction after repeated exposure to indinavir.: Clin Infect Dis. 1998 Feb;26(2):523-4. Unique Identifier : AIDSLINE MED/98161602; Rijnders B; Kooman J; Internal Medicine, University Hospitals, Katholieke Universiteit; Leuven, Belgium.
Helicobacter species strain Mainz isolated from cultures of blood from two patients with AIDS.: Clin Infect Dis. 1998 Feb;26(2):526-7. Unique Identifier : AIDSLINE MED/98161604; Fleisch F; Burnens A; Weber R; Zbinden R; University Hospital, Department of Medical Microbiology, University of; Zurich, Switzerland.
Successful treatment of multicentric Castleman's disease in a patient with human immunodeficiency virus infection.: Clin Infect Dis. 1998 Feb;26(2):527. Unique Identifier : AIDSLINE MED/98161605; Revuelta MP; Nord JA; Saint Vincent's Hospital and Medical Center, New York, New York 10011,; USA.
Cutaneous adverse reactions and CD4+ cell counts in human immunodeficiency virus-infected patients receiving trimethoprim-sulfamethoxazole [letter]: Clin Infect Dis. 1998 Feb;26(2):530-2. Unique Identifier : AIDSLINE MED/98161608; Caumes E
Solitary pulmonary nodule due to Leishmania in a patient with AIDS [letter]: Clin Infect Dis. 1998 Feb;26(2):532-4. Unique Identifier : AIDSLINE MED/98161610; Casado JL; Cuesta C; Sanchez JA; Guerrero A
Non-Hodgkin's lymphoma and family history of malignant tumors in a case-control study (United States).: Cancer Causes Control. 1998 Jan;9(1):77-82. Unique Identifier : AIDSLINE MED/98145871; Zhu K; Levine RS; Gu Y; Brann EA; Hall I; Caplan LS; Baum MK; Department of Family and Preventive Medicine, Meharry Medical College,; Nashville, TN 37208, USA.; Using data from a case-control study in the United States (the Selected Cancers Study), we examined the relationship between non-Hodgkin s lymphoma (NHL) and family history of different cancers. Cases were 1,511 men aged 31 to 59 years and diagnosed
Clinical-grade functional dendritic cells from patients with multiple myeloma are not infected with Kaposi's sarcoma-associated herpesvirus.: Blood. 1998 Mar 15;91(6):1852-7. Unique Identifier : AIDSLINE MED/98158618; Tarte K; Olsen SJ; Yang Lu Z; Legouffe E; Rossi JF; Chang Y; Klein B; Institute for Molecular Genetics, CNRS, Montpellier, France.; Bone marrow dendritic cells (DC) from patients with multiple myeloma (MM) were recently reported to be infected with Kaposi s sarcoma-associated herpesvirus (KSHV). Because immunotherapy strategies using DC are very promising in this disease, we looked for KSHV DNA in clinical-grade DC generated in vitro from MM patie
Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells.: Blood. 1998 Mar 15;91(6):1858-63. Unique Identifier : AIDSLINE MED/98158619; Burger R; Neipel F; Fleckenstein B; Savino R; Ciliberto G; Kalden JR; Gramatzki M; Division of Hematology/Oncology, Department of Medicine III, the; Institute for Clinical and Molecular Virology, University of; Erlangen-Nuernberg, Erlangen, Germany.; Seroepidemiology and polymerase chain reaction studies have strongly suggested that human herpesvirus type 8 (HHV-8) is associated with Kaposi s sarcoma, Castleman s disease, and body cavity-based lymphoma. The genome of HHV-8 harbors a viral analogue of the interleukin-6 (IL-6) gene. The amino acid sequence of the vi
Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.: Blood. 1998 Mar 15;91(6):2108-17. Unique Identifier : AIDSLINE MED/98158649; De SK; Venkateshan CN; Seth P; Gajdusek DC; Gibbs CJ; Oral Infection and Immunity Branch, National Institute of Dental; Research, the Laboratory of Central Nervous System Studies, National; Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; 20892, USA.; To characterize the effect of human immunodeficiency virus-1 HIV-1) nef expression in human monocytes/macrophage (HMO) and U937 on the levels of FcgammaRs, HLA antigens, and monokines, elutriated HMOs and U937 cells were transfected with an adenovirus-mediated Nef expression system. Nef-expressing cells downmodulated
RNA as a drug target: chemical, modelling, and evolutionary tools.: Curr Opin Biotechnol. 1998 Feb;9(1):66-73. Unique Identifier : AIDSLINE MED/98164337; Hermann T; Westhof E; Institut de Biologie Moleculaire et Cellulaire du CNRS, Strasbourg,; France.; Dramatic technical progress in RNA synthesis and structure determination has allowed several difficulties inherent to the preparation, handling and structural analysis of RNA to be overcome, and this has led to a wealth of information about RNA structure and its relationship with biological function. It is now fully r
Interleukin-4 receptor expression in vivo on human AIDS-related Kaposi's sarcoma.: Oncol Res. 1997;9(9):495-503. Unique Identifier : AIDSLINE MED/98154843; Varricchio F; Husain SR; Leland P; Gill P; Puri RK; Division of Biostatistics and Epidemiology, Center for Biologics; Evaluation and Research, FDA, Rockville, MD, USA.; We have investigated the expression of interleukin-4 receptors IL-4R) in acquired immunodeficiency syndrome (AIDS)-related Kaposi s Sarcoma (KS) in situ by immunohistochemistry. Frozen and fixed sections from five patch stage and two nodular stage KS lesions were stained with anti-IL-4R monoclonal antibody with simila
hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease.: Histol Histopathol. 1998 Jan;13(1):155-68. Unique Identifier : AIDSLINE MED/98137127; Fuzzati-Armentero MT; Duchosal MA; Department of Internal Medicine, Centre Hospitalier Universitaire; Vaudois, Lausanne, Switzerland.; The Epstein-Barr virus (EBV) exists in most humans as a lifelong latent infection established in host B cells after a primary viral encounter. In immunosuppressed individuals, such as post-transplant patients, the presence of EBV-infected B cells may lead to lymphoproliferative disease. Injection of human peripheral b
[Profound mycoses in AIDS in Abidjan (Cote d'Ivoire)]: Bull Soc Pathol Exot. 1997;90(5):307-11. Unique Identifier : AIDSLINE MED/98168602; Eholie SP; N'gbocho L; Bissagnene E; Coulibaly M; Ehui E; Kra O; Assoumou A; Aoussi E; Kadio A; Service de maladies infectieuses et tropicales, CHU de Treichville,; Abidjan, Cote d'Ivoire.; During 1995, among 1105 HIV patients explored in our department, 64 presented a deep fungic infection (5.8%). The yeast was searched for in cerebrospinal fluid, blood, urine, and bronchoalveolar aspiration. Isolated germs were Cryptococcus neoformans (95%), Candida tropicalis (1 case), Saccharomyces cerevisiae (1 case
[Etiologic aspects of nephrotic syndrome in Black African adults in a hospital setting in Abidjan]: Bull Soc Pathol Exot. 1997;90(5):342-5. Unique Identifier : AIDSLINE MED/98168611; Diallo AD; Nochy D; Niamkey E; Yao Beda B; Service de medecine Interne, CHU Treichville, Abidjan, Cote d'Ivoire,; France.; We studied nephrotic patients hospitalised in internal medicine service at Treichville Teaching hospital from September 1986 to February 1993 for precising the aetiological aspects of black adult patients and their evolutive biological, clinical and epidemiological profile. Secondary Nephrotic syndrome represented 18%
[Bacterial lung diseases from common bacteria during HIV infection in African adults hospitalized in Abidjan, Cote d'Ivoire]: Bull Soc Pathol Exot. 1997;90(5):370-2. Unique Identifier : AIDSLINE MED/98168618; Koffi N; Ngom A; Kouassi B; Aka-Danguy E; Tchamran M; Service de pneumologie, CHU de Cocody, Abidjan, Cote d'Ivoire.; In this retrospective study, authors compare radiographic and clinical aspects in two groups of patients. They are hospitalized for bacterial pneumonia and distinguished by HIV serological profile (HIV+ or HIV-). Positif HIV serologic is observed in 60% among 96 patients included in this study. An african adult infect
Recent advances. Immunology.: BMJ. 1998 Feb 21;316(7131):600-3. Unique Identifier : AIDSLINE MED/98179419; Kemeny M; Peakman M; Department of Immunology, King's College School of Medicine and; Dentistry, London. m.kemeny@kcl.ac.uk
Ethics and international research. Placebo trials are unethical for established, untested treatments [letter]: BMJ. 1998 Feb 21;316(7131):625-6; discussion 627. Unique Identifier : AIDSLINE MED/98179428; Edi-Osagie EC; Edi-Osagie NE
Ethics and international research. Kenyan statutory body was unaware of study [letter]: BMJ. 1998 Feb 21;316(7131):626. Unique Identifier : AIDSLINE MED/98179431; Baraza R
Ethics and international research. Comparison of short and long zidovudine regimens is appropriate [letter]: BMJ. 1998 Feb 21;316(7131):626; discussion 627. Unique Identifier : AIDSLINE MED/98179429; Lurie P; Wolfe SM
Ethics and international research. Zidovudine is too expensive for developing countries [letter]: BMJ. 1998 Feb 21;316(7131):626; discussion 627. Unique Identifier : AIDSLINE MED/98179430; Burdon J
Ethics and international research. Potential enticement of placebo trials needs to be debated [letter]: BMJ. 1998 Feb 21;316(7131):626-7. Unique Identifier : AIDSLINE MED/98179432; Landray MJ
Ethics and international research. Obtaining informed consent for trials in Africa is possible [letter]: BMJ. 1998 Feb 21;316(7131):627-8. Unique Identifier : AIDSLINE MED/98179433; Godfrey-Faussett P; Mwinga A; Hosp M; Baggaley R; Quigley M; Porter J
Young and recent-onset injecting drug users are at higher risk for HIV.: Addiction. 1997 Nov;92(11):1457-65. Unique Identifier : AIDSLINE MED/98180018; Fennema JS; Van Ameijden EJ; Van Den Hoek A; Coutinho RA; Municipal Health Service, Department of Public Health and Environment,; Amsterdam, The Netherlands.; AIMS: To determine whether young or recent-onset injecting drug users (IDUs) are at increased risk of HIV infection, and to compare trends in risk behaviours and HIV incidence among subgroups of IDUs. DESIGN: Associations of age and onset of injecting with HIV prevalence and injecting risk behaviours were determined a
The host immune response to tuberculosis.: Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):679-91. Unique Identifier : AIDSLINE MED/98176753; Schluger NW; Rom WN; Division of Pulmonary and Critical Care Medicine, New York University; Medical Center and School of Medicine, The Bellevue Chest Service, New; York, USA.
Local immune responses correlate with presentation and outcome in tuberculosis.: Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):729-35. Unique Identifier : AIDSLINE MED/98176760; Condos R; Rom WN; Liu YM; Schluger NW; The Bellevue Chest Service and the Division of Pulmonary and Critical; Care Medicine, New York University Medical Center, New York, USA.; Local cellular immune responses may affect presentation and outcome in tuberculosis (TB). To investigate this hypothesis, we performed bronchoalveolar lavage (BAL) on 30 patients with untreated pulmonary tuberculosis and assessed the type of cellular inflammatory response and cytokine production. We then correlated BA
Serum level of interleukin 8 is elevated in idiopathic pulmonary fibrosis and indicates disease activity.: Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):762-8. Unique Identifier : AIDSLINE MED/98176765; Ziegenhagen MW; Zabel P; Zissel G; Schlaak M; Muller-Quernheim J; Research Center Borstel, Medical Hospital, Germany.; It has been shown that interleukin 8 (IL-8) is increased in bronchoalveolar lavage fluid (BALF) of patients with idiopathic pulmonary fibrosis (IPF) and there is increasing evidence that it is involved in the pathogenesis of this disease. To date, no data are available as to whether IL-8 is elevated in sera of IPF pat
CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease.: Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):822-6. Unique Identifier : AIDSLINE MED/98176774; Saetta M; Di Stefano A; Turato G; Facchini FM; Corbino L; Mapp CE; Maestrelli P; Ciaccia A; Fabbri LM; Institute of Occupational Medicine, University of Padova, Italy.; To investigate whether the inflammatory process in peripheral airways is different in smokers who develop symptoms of chronic bronchitis and chronic airflow limitation and in asymptomatic smokers who do not develop chronic airflow limitation, we examined surgical specimens obtained from 16 smokers undergoing lung rese
Variability of peripheral blood lymphocyte beta-2-adrenergic receptor density in humans.: Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):990-2. Unique Identifier : AIDSLINE MED/98176799; Anstead MI; Hunt TA; Carlson SL; Burki NK; Department of Medicine, University of Kentucky, Lexington 40536-0084,; USA.; Beta2-adrenergic receptor (betaAR) density on peripheral blood lymphocytes has been used as an index to reflect the betaAR state of the body. Lymphocytes betaARs are unequally distributed among lymphocyte subpopulations, with the highest density on CD8+ cells and the lowest on CD4+ cells. Thus, the measurement of peri
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.: Bioorg Med Chem. 1997 Dec;5(12):2133-43. Unique Identifier : AIDSLINE MED/98120632; Hashimoto F; Kashiwada Y; Cosentino LM; Chen CH; Garrett PE; Lee KH; Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.; Two series of lupane-type triterpenoic acid derivatives were synthesized and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells, based on the fact that betulinic acid (1) and dihydrobetulinic acid (9) were identified as anti-HIV agents. Among the derivatives, 3-O-(3 ,3 -dime
Biologically active oligodeoxyribonucleotides--IX. Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3'- and 5'-end-modification.: Bioorg Med Chem. 1997 Dec;5(12):2235-43. Unique Identifier : AIDSLINE MED/98120642; Koizumi M; Koga R; Hotoda H; Momota K; Ohmine T; Furukawa H; Agatsuma T; Nishigaki T; Abe K; Kosaka T; Tsutsumi S; Sone J; Kaneko M; Kimura S; Shimada K; Exploratory Chemistry Research Laboratory, Sankyo Co., Ltd., Tokyo,; Japan. koizum@shina.sankyo.co.jp; We have determined that hexadeoxyribonucleotides (5 TGGGAG3 ), with modified aromatic groups such as a trityl group at the 5 -end, have anti-HIV-1 activity in vitro. The 6-mer bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5 -end had the most potent activity and the least cytotoxicity. When the 3 -end of the 5
Gene therapy.: Curr Biol. 1998 Jan 29;8(3):R73-5. Unique Identifier : AIDSLINE MED/98108039; Vile RG; Imperial Cancer Research Fund, Laboratory of Molecular Therapy, ICRF; Oncology Unit, Imperial College School of Medicine, Hammersmith; Hospital, DuCane Road, London, W12 0NN, UK. r.vile@icrf.icnet.uk
New issues in the management of cytomegalovirus retinitis in AIDS patients.: Am J Health Syst Pharm. 1998 Feb 15;55(4):392-5. Unique Identifier : AIDSLINE MED/98164961; Pau AK; National Institute of Allergy and Infectious Diseases, Pharmacy; Department, Warren G. Magnuson Clinical Center, National Institutes of; Health, Bethesda, MD 20892-1196, USA. apau@nih.gov
Effects of azido-3'-deoxy-thymidine on luteinizing hormone, follicle-stimulating hormone and prolactin release by the pituitary-hypothalamus complex.: Neuroimmunomodulation. 1997 May-Jun;4(3):128-33. Unique Identifier : AIDSLINE MED/98161127; Karanth S; McCann SM; Pennington Biomedical Research Center, Louisiana State University,; Baton Rouge 70808-4124, USA.; Azido-3 -deoxy-thymidine ( AZT ) is a drug extensively used in the treatment of AIDS. AZT was incubated in vitro either with the pituitary-hypothalamus complex (PHc) or the intact pituitary (PI) of male rats. The PHc is comprised of the hypothalamus and
CD4+ cells proliferate after peanut-extract-specific and CD8+ cells proliferate after polyclonal stimulation of PBMC of children with atopic dermatitis [see comments]: Clin Exp Allergy. 1998 Jan;28(1):35-44. Unique Identifier : AIDSLINE MED/98138846; Laan MP; Tibbe GJ; Oranje AP; Bosmans EP; Neijens HJ; Savelkoul HF; Department of Immunology, Erasmus University Rotterdam, The; Netherlands.; BACKGROUND: Few studies describe in vitro food-allergen induced proliferative responses and cytokine production of PBMC of children with atopic dermatitis. This is especially true for peanut-allergen. OBJECTIVES: To analyse the specificity of the T cell in proliferative responses, in children with atopic dermatitis wi
Automated docking and the search for HIV protease inhibitors.: SAR QSAR Environ Res. 1998;8(3-4):273-85. Unique Identifier : AIDSLINE MED/98182948; Olson AJ; Goodsell DS; Department of Molecular Biology, Scripps Research Institute, La Jolla,; CA 92037, USA.; This article will discuss the motivations, technologies, and future directions of computational automated docking in the context of the structure-based rational design of HIV-1 protease inhibitors . Docking simulations are widely used for screening of compound librar
Necotizing gingivostomatitis: NUG to noma.: Compend Contin Educ Dent. 1996 Oct;17(10):951-4, 956, 957-8 passim; quiz 964. Unique Identifier : AIDSLINE MED/98194516; Horning GM; Dental Corps, US Navy, Naval Dental School, Bethesda, Maryland, USA.; Necrotizing gingivostomatitis (NG) is an increasingly rare but potentially serious infection that can present as a spectrum of clinical disease ranging from necrotizing ulcerative gingivitis to noma. The diagnostic triad for NG is pain, interdental ulceration, and gingival bleeding, but many cases also display fetid b
Survey of hepatitis B exposure and sharps injuries in dental health-care professionals.: Compend Contin Educ Dent. 1996 Oct;17(10):986, 990-5. Unique Identifier : AIDSLINE MED/98194518; Schuman NJ; Owens BM; Turner JE; Department of Biologic and Diagnostic Sciences, College of Dentistry,; University of Tennessee, Memphis, USA.; Injuries associated with the category of dental surgical instruments known as sharps (i.e., syringe needles, glass, scalpel blades, dental burs, and hand instruments) are a serious concern for dental professionals because of the possible transmission of communicable diseases such as tuberculosis, hepatitis B virus,
The epidemiology of AIDS/HIV infection: a review for the dentist.: Compend Contin Educ Dent. 1996 Oct;17(10):996-1000, 1002-6. Unique Identifier : AIDSLINE MED/98194519; Grimes RM; Stevenson GC; Bebermeyer RD; Meyer J; School of Public Health and Dental Branch, University of Texas at; Houston, Health Science Center, USA.; This article reviews 14 recently published articles on the epidemiology of human immunodeficiency virus (HIV) infection. Each article is summarized and evaluated for its usefulness in helping the practicing dentist to perform the various roles of diagnosing and treating disease, managing auxiliary staff, providing com
[Church and government on a collision course in the fight against AIDS (news)]: Tidsskr Sykepl. 1997 Jun 3;85(10):42. Unique Identifier : AIDSLINE MED/98144111
[HIV/AIDS is spreading in the world's largest country (news)]: Tidsskr Sykepl. 1997 Jun 3;85(10):42. Unique Identifier : AIDSLINE MED/98144110
["Fighting AIDS with song"--an amplification (letter)]: Tidsskr Sykepl. 1997 Jun 3;85(10):6-7. Unique Identifier : AIDSLINE MED/98144097; Kristensen PG
[Health education--media-related attitude to HIV]: Tidsskr Sykepl. 1997 May 20;85(9):50-2. Unique Identifier : AIDSLINE MED/98144093; Andersen B
Cervical cancer screening in a rural population of Zimbabwe.: Cent Afr J Med. 1997 Sep;43(9):246-51. Unique Identifier : AIDSLINE MED/98170382; Thistle PJ; Chirenje ZM; Salvation Army, Howard Hospital, Glendale, Zimbabwe.; OBJECTIVE: To review cervical cancer screening since its introduction to a rural district hospital in Zimbabwe . DESIGN: Retrospective, descriptive. SETTING: Rural district hospital. SUBJECTS: Data from 419 cervical smears performed on women who had cervical cancer screening as pa
[Current status and development of the HIV/AIDS epidemy (news)]: Z Arztl Fortbild Qualitatssich. 1997 Dec;91(8):780-1. Unique Identifier : AIDSLINE MED/98148615
Colposcopic evaluation of a vaginal gel formulation of iota-carrageenan.: Contraception. 1997 Dec;56(6):387-9. Unique Identifier : AIDSLINE MED/98155877; Elias CJ; Coggins C; Alvarez F; Brache V; Fraser IS; Lacarra M; Lahteenmaki P; Massai R; Mishell DR Jr; Phillips DM; Salvatierra AM; Population Council, New York, New York 10017, USA.; There is an urgent need to develop safe, effective, and acceptable vaginal products for the prevention of sexually transmitted infections. Preliminary in vitro results suggest that vaginal formulations of sulfated polysaccharides, including iota-carrageenan, have the potential to block mucosal transmission of human im
Thoracic empyema in HIV-infected patients: microbiology, management, and outcome.: Chest. 1998 Mar;113(3):732-8. Unique Identifier : AIDSLINE MED/98175604; Hernandez Borge J; Alfageme Michavila I; Munoz Mendez J; Campos Rodriguez F; Pena Grinan N; Villagomez Cerrato R; Department of Internal Medicine, Valme University Hospital, Seville,; Spain.; OBJECTIVES: To evaluate etiology, bacteriology, stage of disease, treatment, and outcome of HIV-infected patients with thoracic empyema (TE) over a 9-year period at a hospital teaching center. DESIGN: We have retrospectively reviewed the charts of all HIV-infected patients with a hospital discharge diagnosis of empyem
Pseudomesotheliomatous adenocarcinoma of the lung in a patient with HIV infection.: Chest. 1998 Mar;113(3):839-41. Unique Identifier : AIDSLINE MED/98175623; Schreiner SR; Kirkpatrick BD; Askin FB; Department of Pathology, Johns Hopkins Hospital, Baltimore, USA.; Clinical and pathologic findings are presented of the first reported case in the English-language medical literature of pseudomesotheliomatous adenocarcinoma (PMA) occurring in an HIV-infected patient. PMA is an uncommon variant of peripheral lung cancer which typically occurs in elderly male patients. It mimics a mal
Treatment of Legionella lung abscess: unanswered questions? [letter]: Chest. 1998 Mar;113(3):845. Unique Identifier : AIDSLINE MED/98175627; Morley JN; Smith LC
Nonspecific airway hyperresponsiveness in HIV disease [letter]: Chest. 1998 Mar;113(3):845-7. Unique Identifier : AIDSLINE MED/98175628; Chiner E; Larramendi CH; Calpe JL; Puigcerver MT
The HIV-positive dental student.: Dentistry. 1994 Apr;14(2):4-11, 27-30, 32. Unique Identifier : AIDSLINE MED/98146654; Koelbl JJ
Crohn's disease stable remission after human immunodeficiency virus infection.: Dig Dis Sci. 1998 Feb;43(2):412-9. Unique Identifier : AIDSLINE MED/98171091; Pospai D; Rene E; Fiasse R; Farahat K; Beaugery L; Lammens P; Reimund C; Duclos B; Le Quintrec Y; Vandercam B; Mignon M; Department of Gastroenterology and Nutrition, Bichat Claude-Bernard; University Hospital, Paris, France.; We retrospectively assessed the clinical course in four patients with long-standing Crohn s disease who became infected with human immunodeficiency virus (HIV). The duration of active Crohn s disease was 21, 10, 4, and 4 years in our four patients. They experienced a stable remission of Crohn s disease symptoms after
Estimation of the effect of neutropenia on rates of clinical bacteraemia in HIV-infected patients.: Epidemiol Infect. 1998 Feb;120(1):71-80. Unique Identifier : AIDSLINE MED/98187669; Caperna J; Barber RE; Toerner JG; Mathews WC; Department of Medicine, UCSD Medical Center, San Diego, CA 92103-8681,; USA.; A retrospective cohort study was conducted to quantitate the relationship between neutropenia and rates of clinical bacteraemia among adults with HIV infection receiving medical care at one institution between 1991-5. The primary exposure, absolute neutrophil count (ANC), was summarized as mean ANC within a given week
[Cytomegalovirus retinitis]: Gac Med Mex. 1997 Nov-Dec;133(6):607-8. Unique Identifier : AIDSLINE MED/98164844; Fierro-Gossman H; Departamento Clinico, Hospital de Especialidades, Centro Medico; Nacional Siglo XXI, IMSS, Mexico, D.F.
[Treatment of tuberculosis]: Gac Med Mex. 1997 Nov-Dec;133(6):613-6. Unique Identifier : AIDSLINE MED/98164846; Soto-Ramirez LE; Departamento de Infectologia, Instituto Nacional de la Nutricion,; Salvador Zubiran, Mexico, D.F.
[Advances in the molecular diagnosis of infectious and parasitic diseases]: Gac Med Mex. 1997;133 Suppl 1:111-24. Unique Identifier : AIDSLINE MED/98164871; Sweet-Cordero A; Santos-Preciado JI; Departamento de Pediatria, Universidad de California en San Francisco,; USA.; During the last decade molecular diagnostic techniques have moved from the research laboratory into the clinical microbiology laboratory. The application of molecular biology for the diagnosis of infections and parasitic diseases by the detection of nucleic acids has steadily grown, and it is very probably that, while
Molecular diagnostics. The polymerase chain reaction and its use in the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae.: Gac Med Mex. 1997;133 Suppl 1:133-7. Unique Identifier : AIDSLINE MED/98164873; Uhrin M; The diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae was performed using classical microbiological techniques of chlamydial cell culture and agar isolation respectively in patients studied in Pittsburgh. The polymerase chain reaction PCR) was compared to standard procedures used for diagnosing these sexual
[Workshop on Molecular Epidemiology of Viral Diseases]: Gac Med Mex. 1997;133 Suppl 1:63-8. Unique Identifier : AIDSLINE MED/98164861; Gomez B; Cabrera L; Arias CF; Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico,; D.F.; A workshop on viral epidemiology was held on September 29, 1995 at the Medical School of the Universidad Nacional Autonoma de Mexico . The aim of this workshop was to promote interaction among scientists working in viral epidemiology. Eighteen scientists from ten institutions presen
Playing with angels.: Imprint. 1998 Jan;45(1):64. Unique Identifier : AIDSLINE MED/98166507; Richard C; St. Joseph's College, Maine, USA.
Evolution of the primary immune response to Histoplasma capsulatum in murine lung.: Infect Immun. 1998 Apr;66(4):1473-81. Unique Identifier : AIDSLINE MED/98187919; Cain JA; Deepe GS Jr; Department of Medicine, University of Cincinnati College of Medicine,; Ohio 45267-0560, USA.; Histoplasma capsulatum induces a cell-mediated immune response in the lungs and lymphoid organs of mammals. In this study, we analyzed the progression of the cytokine and inflammatory reactions in the lungs of mice infected intranasally with H. capsulatum. We measured cytokine mRNA levels and determined the inflammato
Vaccination with plasmid DNA encoding mycobacterial antigen 85A stimulates a CD4+ and CD8+ T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection.: Infect Immun. 1998 Apr;66(4):1527-33. Unique Identifier : AIDSLINE MED/98187926; Denis O; Tanghe A; Palfliet K; Jurion F; van den Berg TP; Vanonckelen A; Ooms J; Saman E; Ulmer JB; Content J; Huygen K; Department of Virology, Pasteur Institute of Brussels, Belgium.; Vaccination of mice with plasmid DNA carrying the gene for the major secreted mycobacterial antigen 85A (Ag85A) from Mycobacterium tuberculosis is a powerful technique for generating robust specific Thl helper T-cell responses, CD8+-mediated cytotoxicity, and protection against M. tuberculosis challenge K. Huygen et a
Antigen-specific CD8+ T cells protect against lethal toxoplasmosis in mice infected with Neospora caninum.: Infect Immun. 1998 Apr;66(4):1554-60. Unique Identifier : AIDSLINE MED/98187930; Kasper LH; Khan IA; Department of Medicine (Neurology), Dartmouth Medical School, Hanover,; New Hampshire 03755, USA. lloyd.kaspar@dartmouth.edu; Neospora caninum is a coccidial protozoan parasite that appears morphologically indistinguishable from Toxoplasma gondii and that infects a large range of mammals. Both inbred and outbred strains of mice exhibit a high degree of resistance to infection with N. caninum. Three inbred strains of mice (A/J, BALB/c, and C5
Left ventricular dysfunction in human immunodeficiency virus HIV)-infected patients.: Int J Cardiol. 1998 Jan 5;63(1):37-45. Unique Identifier : AIDSLINE MED/98141247; Cardoso JS; Moura B; Martins L; Mota-Miranda A; Rocha Goncalves F; Lecour H; Oporto Cardiovascular Research and Development Unit (JNCIT 51/94),; Oporto Medical School, Hospital de S. Joao, Porto, Portugal.; We evaluated left ventricular function by echocardiography in a prospective study that included 98 consecutive human immunodeficiency virus (HIV)-infected patients and 40 HIV-seronegative normal controls. When compared with controls, HIV patients showed increased isovolumic relaxation time 101+/-18 ms versus 71+/-10 m
Cryptosporidium parvum infection in bovine neonates: dynamic clinical, parasitic and immunologic patterns.: Int J Parasitol. 1998 Jan;28(1):49-56. Unique Identifier : AIDSLINE MED/98162859; Fayer R; Gasbarre L; Pasquali P; Canals A; Almeria S; Zarlenga D; United States Department of Agriculture, Agricultural Research; Service, Immunology and Disease Resistance Laboratory, Beltsville, MD; 20705, USA. rfayer@ggpl.arsusda.gov; Twenty-six experimentally infected calves were monitored daily for oocyst excretion. All began excreting oocysts 3-6 days p.i. Most calves (n = 23) excreted oocysts for 6-9 days, with a daily range from 4 x 10(2) to 4.15 x 10(7) oocysts g(-1) of faeces. Over half the calves excreted peak numbers of oocysts 6-8 days p.
Death in denial.: Hastings Cent Rep. 1997 Nov-Dec;27(6):23; discussion 24-5. Unique Identifier : AIDSLINE MED/98134832; Guiles RM; Appelbaum PS; University of Massachusetts Medical School, USA.
Impact of comorbidity on outcome of young patients with head and neck squamous cell carcinoma.: Head Neck. 1998 Jan;20(1):1-7. Unique Identifier : AIDSLINE MED/98124592; Singh B; Bhaya M; Zimbler M; Stern J; Roland JT; Rosenfeld RM; Har-El G; Lucente FE; Department of Otolaryngology, State University of New York Health; Science Center at Brooklyn, The Long Island College Hospital, 11201,; USA.; BACKGROUND: Comorbid conditions have a significant impact on the actuarial survival of patients with head and neck cancer. However, no studies have evaluated the impact of comorbidity on tumor- and treatment-specific outcomes. This study was performed to evaluate the impact of comorbidity, graded by the Kaplan-Feinste
HIV infected women and women's services.: Health Care Women Int. 1998 Mar-Apr;19(2):131-9. Unique Identifier : AIDSLINE MED/98187081; Russell JM; Smith K; School of Nursing, University of Missouri, Kansas City 64108, USA.; HIV/AIDS is increasing faster in women than any other segment in the population. The typical woman who is HIV infected is young, poor, a minority, and in the childbearing stage of life. Only 1 study was found that explored medical services in relation to usage and cost by men and women infected with HIV (F.J. Hellinge
AIDS awareness among women: the benefit of culturally sensitive educational programs.: Health Care Women Int. 1998 Mar-Apr;19(2):141-53. Unique Identifier : AIDSLINE MED/98187082; Majumdar B; Roberts J; School of Nursing, McMaster University, Hamilton, Ontario, Canada.; AIDS affects everyone, regardless of race, age, or religion; hence, information must be accessible to everyone. This descriptive study identified the need to generate culturally sensitive educational programs and evaluated their effect. Culturally sensitive AIDS educational training was offered to culturally diverse w
Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B.: J Biol Chem. 1998 Mar 6;273(10):5443-6. Unique Identifier : AIDSLINE MED/98157930; Shen Q; Wu R; Leonard JL; Newburger PE; Department of Pediatrics, University of Medical Center, Worcester,; Massachusetts 01605, USA.; Prokaryotic and eukaryotic cells incorporate the unusual amino acid selenocysteine at a UGA codon, which conventionally serves as a termination signal. Translation of eukaryotic selenoprotein mRNA requires a nucleotide selenocysteine insertion sequence in the 3 -untranslated region. We report the molecular cloning of
HIV-1 gp120 accelerates Fas-mediated activation-induced human lamina propria T cell apoptosis.: J Clin Immunol. 1998 Jan;18(1):39-47. Unique Identifier : AIDSLINE MED/98133499; Boirivant M; Viora M; Giordani L; Luzzati AL; Pronio AM; Montesani C; Pugliese O; Immunology Department, Istituto Superiore di Sanita, Rome, Italy.; Intestinal mucosa represents an important portal of entry of HIV and a site of virus reservoir and active replication. Recently, in HIV patients, an early depletion of intestinal lamina propria T lymphocytes (LPT) has been described. HIV-1 gp120 has been demonstrated to promote apoptosis in noninfected isolated periph
Candida dubliniensis: characteristics and identification.: J Clin Microbiol. 1998 Feb;36(2):329-34. Unique Identifier : AIDSLINE MED/98126212; Sullivan D; Coleman D; Department of Oral Surgery, Oral Medicine and Pathology, Dublin Dental; Hospital, University of Dublin, Republic of Ireland.
Evaluation of a new competitive immunoassay (BioElisa Syphilis) for screening for Treponema pallidum antibodies at various stages of syphilis.: J Clin Microbiol. 1998 Feb;36(2):358-61. Unique Identifier : AIDSLINE MED/98126217; Ebel A; Bachelart L; Alonso JM; Institut Alfred Fournier, French National Reference Center for; Sexually Transmitted Diseases, World Health Organization Collaborating; Center for Treponematoses, Paris.; The BioElisa Syphilis, a new competitive enzyme immunoassay (EIA) for Treponema pallidum whole antigen that uses specific human immunoglobulin G (IgG) antibodies as the competitor, was evaluated for potential use in screening for syphilis at various stages. The results obtained by this competitive EIA were compared wi
Molecular fingerprinting of Mycobacterium tuberculosis and risk factors for tuberculosis transmission in Paris, France, and surrounding area.: J Clin Microbiol. 1998 Feb;36(2):486-92. Unique Identifier : AIDSLINE MED/98126240; Gutierrez MC; Vincent V; Aubert D; Bizet J; Gaillot O; Lebrun L; Le Pendeven C; Le Pennec MP; Mathieu D; Offredo C; Pangon B; Pierre-Audigier C; Centre National de Reference des Mycobacteries, Institut Pasteur,; Paris, France.; Forty-three percent of the tuberculosis cases reported in France are from the Ile de France region. The incidence of tuberculosis in this region is 33 cases per 100,000 inhabitants, twice the national average. A restriction fragment length polymorphism RFLP) analysis was performed
Stability of human immunodeficiency virus RNA in blood specimens as measured by a commercial PCR-based assay.: J Clin Microbiol. 1998 Feb;36(2):493-8. Unique Identifier : AIDSLINE MED/98126241; Sebire K; McGavin K; Land S; Middleton T; Birch C; State Reference Laboratory for HIV Isolation, Victorian Infectious; Diseases Reference Laboratory, Fairfield, Australia.; We investigated the effects of conditions often encountered during handling, transit, and storage of blood specimens on the quantity of detectable human immunodeficiency virus (HIV) RNA in plasma. HIV RNA copy numbers were measured with a commercially available assay (the Amplicor HIV-1 Monitor test kit). Variables ex
Amplification of full-length hepatitis B virus genomes from samples from patients with low levels of viremia: frequency and functional consequences of PCR-introduced mutations.: J Clin Microbiol. 1998 Feb;36(2):531-8. Unique Identifier : AIDSLINE MED/98126247; Gunther S; Sommer G; Von Breunig F; Iwanska A; Kalinina T; Sterneck M; Will H; Heinrich-Pette-Institut fur Experimentelle Virologie und Immunologie; an der Universitat Hamburg, Federal Republic of Germany.; will@hpi.uni-hamburg.de; To facilitate the investigation of hepatitis B virus (HBV) sequence variation, we recently established a method for functional analysis of PCR-amplified full-length HBV genomes. This study aimed at estimating the number of mutations introduced during amplification of genomes from samples from patients with low levels
Oligonucleotide ligation assay for detecting mutations in the human immunodeficiency virus type 1 pol gene that are associated with resistance to zidovudine, didanosine, and lamivudine.: J Clin Microbiol. 1998 Feb;36(2):569-72. Unique Identifier : AIDSLINE MED/98126255; Edelstein RE; Nickerson DA; Tobe VO; Manns-Arcuino LA; Frenkel LM; Department of Pediatrics, University of Washington, Seattle, USA.; This report describes the detection of mutations in the pol gene of human immunodeficiency virus type 1 associated with resistance to zidovudine, didanosine, and lamivudine by genotyping by an oligonucleotide ligation assay specific codons in the pol gene amplified by PCR. Our studies demonstrate the sensitivity, simp
Multicenter evaluation of the new automated Enzymun-Test Anti-HIV 1 + 2 + subtyp O.: J Clin Microbiol. 1998 Feb;36(2):580-4. Unique Identifier : AIDSLINE MED/98126258; Weber B; Institut fur Medizinische Virologie, Universitatskliniken Frankfurt am; Main, Germany.; An international multicenter study was performed to evaluate a new, automated human immunodeficiency virus (HIV) third-generation antibody assay. The Enzymun-Test Anti-HIV 1 + 2 Subtyp O showed 100% sensitivity and 99.8% specificity among 11,172 samples from hospitalized patients and blood donors. For early HIV antibo
Restraint stress-induced thymic involution and cell apoptosis are dependent on endogenous glucocorticoids.: J Neuroimmunol. 1998 Feb;82(1):40-6. Unique Identifier : AIDSLINE MED/98186039; Tarcic N; Ovadia H; Weiss DW; Weidenfeld J; Lautenberg Center for General and Tumor Immunology, The Hebrew; University Hadassah Medical School, Jerusalem, Israel.; The aim of this study was to investigate the specific role of endogenous glucocorticoids (GC) following restraint stress on thymic involution and apoptosis. Restraint stress has been reported to alter physiological and behavioral responses in experimental animals. Exposure of mice to restraint stress led to involution
Pneumocystis carinii inhibits cyclin-dependent kinase activity in lung epithelial cells.: J Clin Invest. 1998 Mar 1;101(5):1148-55. Unique Identifier : AIDSLINE MED/98153242; Limper AH; Edens M; Anders RA; Leof EB; Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care,; and Internal Medicine, Department of Medicine, Mayo Clinic, Rochester,; Minnesota 55905, USA.; Pneumocystis carinii remains an important cause of pneumonia in patients with AIDS. Attachment of the organism to epithelial cells is a central event in establishing infection, impairing the growth potential of lung epithelial cells and thereby slowing repair. In light of investigations documenting a central role for
Detection of human herpesvirus-8 DNA in Kaposi's sarcomas from iatrogenically immunosuppressed patients.: J Am Acad Dermatol. 1998 Mar;38(3):429-37. Unique Identifier : AIDSLINE MED/98178847; Rady PL; Hodak E; Yen A; Memar O; Trattner A; Feinmesser M; David M; Hudnall SD; Tyring SK; Department of Pediatrics, The University of Texas Medical Branch,; Galveston 77555-1019, USA.; BACKGROUND: Kaposi s sarcoma (KS) accounts for more than 5% of malignancies in immunosuppressed organ transplant patients (OKS). A new herpesvirus (HHV-8) was identified with high prevalence in biopsy specimens of AIDS-KS, endemic KS, and classic KS and in OKS. KS has also been associated with other underlying disease
Follicular mycosis fungoides [letter]: J Am Acad Dermatol. 1998 Mar;38(3):502-3. Unique Identifier : AIDSLINE MED/98178863; Carrington PR
AIDS rates improve [news]: J Am Dent Assoc. 1998 Feb;129(2):152, 156. Unique Identifier : AIDSLINE MED/98156150
Role of dentinal carious lesions in the pathogenesis of oral candidiasis in HIV infection.: J Am Dent Assoc. 1998 Feb;129(2):187-94. Unique Identifier : AIDSLINE MED/98156154; Jacob LS; Flaitz CM; Nichols CM; Hicks MJ; University of Texas-Houston Health Science Center, Dental Branch, USA.; The authors describe a clinicopathologic study that evaluated whether dentinal carious lesions are colonized by candidal organisms--and if so, whether there is a relationship between dentinal carious lesion colonization and clinical oral candidiasis, or OC, in HIV infection. Using light microscopy, the authors examine
Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children.: J Am Coll Nutr. 1998 Feb;17(1):25-9. Unique Identifier : AIDSLINE MED/98137873; Agostoni C; Zuccotti GV; Riva E; Decarlis S; Bernardo L; Bruzzese MG; Giovannini M; Department of Pediatrics, University of Milan Medical School, San; Paolo Hospital, Italy.; OBJECTIVE: To assess the plasma fatty acid status of a group of well-nourished children with the human immunodeficiency virus type-1 (HIV-1) and how this relates to the blood total CD4+ lymphocyte count. SUBJECTS: Fourteen HIV-1 seropositive children at various stages of disease and with adequate growth indices were a
Lamivudine resistance in chronic hepatitis B [letter]: J Hepatol. 1998 Jan;28(1):169. Unique Identifier : AIDSLINE MED/98140928; Atkins M; Gray DF
Bartonella-associated infections.: Infect Dis Clin North Am. 1998 Mar;12(1):137-55. Unique Identifier : AIDSLINE MED/98155939; Spach DH; Koehler JE; Division of Infectious Diseases, University of Washington, Seattle,; USA.; Bartonella-associated infections occur in immunocompetent and immunocompromised patients. The spectrum of diseases caused by Bartonella species has expanded and now includes cat-scratch disease, bacillary angiomatosis , bacillary peliosis, bacteremia, endocarditis, and trench
Multiple drug-resistant tuberculosis.: Infect Dis Clin North Am. 1998 Mar;12(1):157-72. Unique Identifier : AIDSLINE MED/98155940; Bradford WZ; Daley CL; Division of Infectious Diseases, San Francisco General Hospital,; California, USA.; The national and international emergence of drug-resistant M. tuberculosis has complicated both the programmatic control of the tuberculosis epidemic and the clinical management of individual cases. In the United States , the problem of MDR tuberculosis is regionalized and likely stems
Emerging issues in blood safety.: Infect Dis Clin North Am. 1998 Mar;12(1):217-29. Unique Identifier : AIDSLINE MED/98155944; Chamberland M; Khabbaz RF; Division of Viral and Rickettsial Diseases, National Center for; Infectious Diseases, Centers for Disease Control and Prevention,; Atlanta, Georgia, USA.; Improvements in donor selection, testing of donors for markers of infection, and viral inactivation of plasma-derived products have helped reduce the risk of transfusion-associated infections, including hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency viruses (HIV). The potential for transmission of em
Emerging infectious diseases and travel medicine.: Infect Dis Clin North Am. 1998 Mar;12(1):231-41. Unique Identifier : AIDSLINE MED/98155945; Ostroff SM; Kozarsky P; National Center for Infectious Diseases, Centers for Disease Control; and Prevention, Atlanta, Georgia, USA.; International movement of individuals, populations, and products is one of the major factors associated with the emergence and reemergence of infectious diseases as the pace of global travel and commerce increases rapidly. Travel can be associated with disease emergence because (1) the disease arises in an area of hea
Group O human immunodeficiency virus-1 infections.: Infect Dis Clin North Am. 1998 Mar;12(1):39-46. Unique Identifier : AIDSLINE MED/98155932; Jaffe HW; Schochetman G; Division of AIDS, STD, and TB Laboratory Research, National Center for; Infectious Diseases, Centers for Disease Control and Prevention,; Atlanta, Georgia, USA.; Human immunodeficiency viruses (HIV), the cause of AIDS, have remarkable genetic diversity. Among the HIV-1 viruses are the major (group M) HIV-1 subtypes and genetic outliers that have been designated as group O viruses. Group O viruses are most prevalent in parts of Africa, although they have also been reported i
Herpes simplex virus-2 infection. An emerging disease?: Infect Dis Clin North Am. 1998 Mar;12(1):47-61. Unique Identifier : AIDSLINE MED/98155933; Schomogyi M; Wald A; Corey L; Department of Medicine, University of Washington School of Medicine,; Seattle, USA.; Genital herpes infections continue to increase in the world. As outlined previously, several factors play a role in the continued transmission of genital herpes worldwide. Reducing the medical consequences of HSV-2 infection will not be easy. It is also sobering to realize that
Kaposi's sarcoma and human herpesvirus-8.: Infect Dis Clin North Am. 1998 Mar;12(1):63-82. Unique Identifier : AIDSLINE MED/98155934; Greenblatt RM; Infectious Diseases Division, University of California San Francisco,; USA.; KS is a major cause of morbidity and mortality among AIDS patients and a treatment problem in the sporadic cases that are not associated with HIV. All four forms of the disease are linked to a newly described herpesvirus, HHV-8 or KSHV, via strong epidemiologic associations and biologic plausibility as a causal agent.
[Characteristic situation on prevention of nosocomial infection in the hospital for the severely multi-disabled--experiences in care and treatment of 4 kinds of viral hepatitis]: Kansenshogaku Zasshi. 1997 Dec;71(12):1238-45. Unique Identifier : AIDSLINE MED/98144880; Machida Y; Tanaka H; Yano Y; Yano T; Yoshida K; Kibou-no-Yiye Ryouiku Hospital for the Severely Motorially and; Intellectually Disabled.; We experienced Hepatitis A, B, C and fulminant hepatitis due to Herpes simplex virus type 1 (HSV-1) in our hospital for the severely multi-disabled (SMD) who had both severe motor and intellectual disabilities, and some of whom might be further complicated by blindness and/or deafness. In this hospital, 100 SMDs are h
[Increased IL-2 and sIL-2R in sera of infants with HTLV-I infection from mother]: Kansenshogaku Zasshi. 1998 Jan;72(1):17-24. Unique Identifier : AIDSLINE MED/98164530; Mori K; Sadamasu K; Tabei Y; Monma K; Hirata I; Sekine H; Itoh T; Watanabe T; Department of Microbiology, Tokyo Metropolitan Research Laboratory of; Public Health.; In our laboratory, children born to women are known to be infected with Human T-cell Leukemia Virus type-1 (HTLV-I) have been followed using, detect of gene by PCR and antibody by Western Blot Assay (WB) and Immunofluorescence Assay (IFA) test from 1990 through 1996. Four children out of 123 delivery cases have been c
The concept of type-1 and type-2 helper T cells and their cytokines in humans.: Int Rev Immunol. 1998;16(3-4):427-55. Unique Identifier : AIDSLINE MED/98166096; Del Prete G; Faculty of Medicine, University of Florence, Italy.; In both mice and humans, functionally distinct helper T (Th)-cell subsets, known as Th1 and Th2 cells, are characterized by the patterns of cytokines they produce. These two polarized forms of the specific cellular immune response provide a useful model for explaining not only the different types of protection, but al
The Th1/Th2 paradigm in allergic bronchopulmonary aspergillosis [editorial; comment]: J Lab Clin Med. 1998 Mar;131(3):194-6. Unique Identifier : AIDSLINE MED/98182015; Schuyler M
Rationale for immune-based therapies for HIV-1 infection.: J Lab Clin Med. 1998 Mar;131(3):197-206. Unique Identifier : AIDSLINE MED/98182016; Valdez H; Al-Harthi L; Landay A; Lederman MM; Center for AIDS Research and the Division of Infectious Diseases, Case; Western Reserve University, USA.
Case 4: Kaposi's sarcoma [clinical conference]: J Calif Dent Assoc. 1997 Aug;25(8):559-62, 578. Unique Identifier : AIDSLINE MED/98195960; Carpenter WM; Department of Diagnostic Sciences, University of the Pacific School of; Dentistry.
Re: Multiple vaccination [letter]: J R Soc Health. 1997 Dec;117(6):401. Unique Identifier : AIDSLINE MED/98180210; Webb M
Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.: J Mol Biol. 1998 Feb 13;276(1):113-29. Unique Identifier : AIDSLINE MED/98179554; Finer-Moore JS; Liu L; Birdsall DL; Brem R; Apfeld J; Santi DV; Stroud RM; Department of Biochemistry and Biophysics, University of California,; San Francisco 94143-0448, USA.; We have determined structures of binary and ternary complexes of five Asn229 variants of thymidylate synthase (TS) and related their structures to the kinetic constants measured previously. Asn229 forms two hydrogen bonds to the pyrimidine ring of the substrate 2 -deoxyuridine-5 -monophosphate (dUMP). These hydrogen b
The safer choices project: methodological issues in school-based health promotion intervention research.: J Sch Health. 1997 Nov;67(9):365-71. Unique Identifier : AIDSLINE MED/98131885; Basen-Engquist K; Parcel GS; Harrist R; Kirby D; Coyle K; Banspach S; Rugg D; Dept. of Behavioral Science, University of Texas M.D. Anderson Cancer; Center, Houston 77030, USA.; Randomized trials of school-based health promotion programs present unique design and analytical issues not widely discussed in the research literature. This article describes the Safer Choices study--a school-based program for prevention of HIV, other sexually transmitted diseases, and pregnancy--to illustrate critic
AIDS knowledge and attitudes of health-care workers in Mexico.: J Soc Psychol. 1998 Apr;138(2):203-10. Unique Identifier : AIDSLINE MED/98185806; Fusilier M; Manning MR; Santini Villar AJ; Torres Rodriguez D; Division of Business, Northwestern State University of Louisiana, USA.; AIDS threatens to spread rapidly in Mexico . In the present study, results of a survey of 204 Mexican employees in hospitals and doctors offices indicated that those health-care workers were largely knowledgeable about the illness. A majority were willing to provide AIDS care, alth
[Policy program to minimize spread of infection. Prolonged cough may be a sign of tuberculosis]: Lakartidningen. 1998 Mar 4;95(10):1010-2, 1015-6. Unique Identifier : AIDSLINE MED/98188691; Fredlund H; Larsson LO; Blom-Bulow B; Julander I; Normann B; Romanus V; Wahlstrom H; Smittskyddsenheten, Regionsjukhuset, Orebro.; In a worldwide epidemiological perspective, Sweden is well favoured with an annual tuberculosis incidence of approximately six cases per 100,000 of the population. Neither the impact of the HIV pandemic nor the occurrence of multiresistant strains of Mycobacterium tuberculosis has
Effect of anti-IL-4 and anti-IL-5 antibodies on allergic airway hyperresponsiveness in mice.: Life Sci. 1998;62(13):PL169-74. Unique Identifier : AIDSLINE MED/98178617; Tanaka H; Nagai H; Maeda Y; Department of Pharmacology, Gifu Pharmaceutical University, Japan.; In order to study the role of IL-4 and IL-5 in allergen-induced airway hyperresponsiveness in mice, the effect of the combined administration of anti-IL-4 and anti-IL-5 monoclonal antibodies mAbs) on IgE response, airway inflammation and airway hyperresponsiveness was studied in sensitized Balb/c mice. Three inhalatio
[The impact of HIV infection on the incidence of syphilis and gonorrhea at a university hospital (1985-1994)]: Medicina (B Aires). 1997;57(1):1-6. Unique Identifier : AIDSLINE MED/98097488; Griemberg G; Pizzimenti MC; Famiglietti AM; Belli L; Vay C; Garcia S; Cardinalli A; Costa MA; Marcenac F; Casco RH; Laboratorio de Inmunologia Clinica, Facultad de Farmacia y Bioquimica,; Hospital de Clinicas Jose de San Martin, Facultad de Medicina,; Universidad de Buenos Aires.; Syphilis and gonorrhea are two sexually transmitted diseases STD) which still persist in spite of the existence of effective treatment. In this paper the incidence of these two diseases was evaluated between 1985-1994, a decade during which the problem of HIV infection arose. Every patient who attended the STD Program
[Advances in antiretroviral treatment]: Medicina (B Aires). 1997;57(1):87-94. Unique Identifier : AIDSLINE MED/98097503; Davaro RE; Losso MH; II Catedra de Farmacologia, Facultad de Medicina, Universidad de; Buenos Aires, Argentina.; Recent findings have led to important changes in the understanding of HIV kinetics that allowed a novel therapeutic approach. This article reviews the most common methods used to gauge viral load and their use in medical decision making, the characteristics of the prote
Fas-mediated cytotoxicity induces degradation of vesicular stomatitis virus RNA transcripts and reduces viral titer.: Mol Immunol. 1997 Oct;34(15):1055-66. Unique Identifier : AIDSLINE MED/98178579; Montel AH; Hommel-Berrey G; Brahmi Z; Department of Microbiology/Immunology, Indiana University School of; Medicine, Indianapolis 46202-5200, USA.; Several investigators have recently examined the effect of Fas CD95)-mediated apoptotic cell death on target cells (TC). The effect of Fas-mediated death on viral RNA within the TC, however, has not been explored. In this study, we investigated the ability of the Fas pathway to mediate pre-lytic degradation of vesicul
Efficacy of a short-term amphotericin B + flucytosine combination therapy followed by itraconazole monotherapy in acute and chronic AIDS-associated cryptococcosis.: Mycoses. 1997 Oct;40(5-6):203-7. Unique Identifier : AIDSLINE MED/98136966; Parisi A; Malfitano A; Bruno R; Calderon W; Sacchi P; Patruno SF; Filice G; Department of Infectious and Tropical Diseases, University of Pavia,; Italy.; The authors report the clinical and microbiological findings of a 6-month follow-up of nine AIDS patients affected with cryptococcosis. Among these, seven patients suffered from meningoencephalitis and two from disseminated infection. The antifungal therapy during acute illness included the administration of amphoteri
High-dose therapy with fluconazole > or = 800 mg day-1.: Mycoses. 1997 Nov;40(7-8):267-77. Unique Identifier : AIDSLINE MED/98136986; Duswald KH; Penk A; Pittrow L; Chirurgische Klinik, Ludwig-Maximilians-Universitat Munchen, FR; Germany.; Fluconazole dosages greater than 800 mg day-1 have been reported in about 900 patients treated for candidemia, oropharyngeal candidiasis and cryptococcal meningitis in HIV-infected patients, and for initial therapy of endemic mycoses. In patients with life-threatening infections caused by Candida spp., Cryptococcus ne
Prevalence of serotype D in Cryptococcus neoformans isolates from HIV positive and HIV negative patients in Italy.: Mycoses. 1997 Nov;40(7-8):297-302. Unique Identifier : AIDSLINE MED/98136990; Tortorano AM; Viviani MA; Rigoni AL; Cogliati M; Roverselli A; Pagano A; Istituto di Igiene e Medicina Preventiva, Universita degli Studi di; Milano, IRCCS Ospedale Maggiore, Italy.; Cryptococcus neoformans strains isolated from 207 HIV positive and HIV negative patients hospitalized in Northern Italy were serotyped by slide agglutination. One Brazilian HIV negative woman was infected by var. gattii serotype B and all the other patients by var. neoformans, serot
Diagnosis of fungal infections.: Mycoses. 1997;40 Suppl 2:13-5. Unique Identifier : AIDSLINE MED/98136975; Fussle R; Institut fur Medizinische Mikrobiologie, Universitat Giessen, Germany.; Fungal infections become more and more important due to their increasing incidence in immunocompromised patients. In these patients opportunistic fungi (Candida, Aspergillus, Cryptococcus) can cause life-threatening infections. Diagnosis of fungal infections is difficult. Clinical symptoms are uncharacteristic, and la
Improvement in CD4+ cell counts despite persistently detectable HIV load [letter]: N Engl J Med. 1998 Apr 9;338(15):1074-5. Unique Identifier : AIDSLINE MED/98181815; Levitz SM
Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein.: Neuroscience. 1998 Jan;82(1):97-106. Unique Identifier : AIDSLINE MED/98144500; Cheng J; Nath A; Knudsen B; Hochman S; Geiger JD; Ma M; Magnuson DS; Department of Physiology, University of Manitoba Faculty of Medicine,; Winnipeg, Canada.; Neuronal dysfunction and cell death in patients with human immunodeficiency virus type-1 (HIV-1) infection may be mediated by HIV-1 proteins and products released from infected cells. Two HIV-1 proteins, the envelope glycoprotein gp120 and nonstructural protein Tat, are neurotoxic. We have determined the neuroexcitato
Pharmacological mechanism of topical lodoxamide treatment in vernal keratoconjunctivitis: a flow-cytometric study.: Ophthalmic Res. 1998;30(1):37-43. Unique Identifier : AIDSLINE MED/98144580; Avunduk AM; Avunduk MC; Dayanir V; Tekelioglu Y; Dayioglu YS; Department of Ophthalmology, Karadeniz Technical University, School of; Medicine, Trabzon, Turkey. avunduk@meds.ktu.edu.tr; The aim of this study was to investigate the possible effect of lodoxamide 0.1% ophthalmic solution (LOS) on tear T lymphocytes, especially Th2 (T helper 2 subgroup of helper T lymphocytes), in the tear specimens of patients with vernal keratoconjunctivitis VKC) and to explore the mechanism of the anti-allergic effect
Spontaneous proliferative response of peripheral blood mononuclear cells in vitro as an indicator of high response to human T-lymphotropic virus type 1 infection in an infant with interstitial pneumonia.: Pediatr Infect Dis J. 1998 Feb;17(2):166-8. Unique Identifier : AIDSLINE MED/98152813; Takezaki T; Setoyama M; Takezaki T; Takei S; Yashiki S; Sueyoshi K; Fukunaga H; Department of Pediatrics, Faculty of Medicine, Kagoshima University,; Japan.
Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.: Pharm Res. 1997 Dec;14(12):1824-9. Unique Identifier : AIDSLINE MED/98115165; Shaw JP; Sueoko CM; Oliyai R; Lee WA; Arimilli MN; Kim CU; Cundy KC; Gilead Sciences, Inc., Foster City, California 94404, USA.; PURPOSE: A series of prodrugs designed to enhance the oral bioavailability of the antiretroviral agent 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA; 1) have been synthesized, including a bis-(acyloxymethyl) ester 2 and a series of bis-(alkoxycarbonyloxymethyl) esters 3-9. The in vitro biological stability and in vi
[Histiocytic cytophagic panniculitis]: Presse Med. 1997 Dec 20;26(40):1987-91. Unique Identifier : AIDSLINE MED/98198107; Lipsker D; Grosshans E; Clinique dermatologique des Hopitaux Universitaires de Strasbourg.; A HISTOPATHOLOGICAL DIAGNOSIS: Histiocytic cytophagic panniculitis is the specific skin finding in the reactive hemophagocytic syndrome. It is a feverish nodular eruption which accompanies the other clinical and biological features of the reactive hemophagocytic syndrome. Histopathologic changes are diagnostic and con
A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.: Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2146-51. Unique Identifier : AIDSLINE MED/98151480; Xiao H; Tao Y; Greenblatt J; Roeder RG; Laboratory of Biochemistry and Molecular Biology, The Rockefeller; University, New York, NY 10021, USA.; Replication of HIV-1 requires the viral Tat protein, which increases the extent of transcription elongation by RNA polymerase II after activation at the single viral long terminal repeat (LTR) promoter. This effect of Tat on transcription requires Tat interactions with a 5 region (TAR) in nascent transcripts as well
Prevention of Th2-mediated murine allergic airways disease by soluble antigen administration in the neonate.: Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2441-5. Unique Identifier : AIDSLINE MED/98151531; Hogan SP; Foster PS; Charlton B; Slattery RM; Division of Biochemistry and Molecular Biology, John Curtin School of; Medical Research, Australian National University, Canberra, ACT 0200,; Australia.; It has been demonstrated recently that neonatal antigen administration in the mouse can lead to priming for Th2-mediated immune responses. This observation has important implications for the development of vaccination strategies in humans, particularly for individuals who may be predisposed to atopy or asthma. In this
Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site.: Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2452-7. Unique Identifier : AIDSLINE MED/98151533; Azimi N; Brown K; Bamford RN; Tagaya Y; Siebenlist U; Waldmann TA; Metabolism Branch, Division of Clinical Sciences, National Cancer; Institute, National Institutes of Health, 9000 Rockville Pike,; Bethesda, MD 20892, USA. nazli@helix.nih.gov; Interleukin 15 (IL-15) mRNA is expressed in a wide variety of tissue types. However, with the exception of some T cell lines, IL-15 transcript expression has not been described in T cells. Herein we demonstrate that IL-15 mRNA can be detected in freshly isolated normal T cells and T cell lines. Furthermore, its expres
CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses.: Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2458-62. Unique Identifier : AIDSLINE MED/98151534; Maecker HT; Do MS; Levy S; Department of Medicine/Oncology, Stanford University Medical Center,; Stanford, CA 94305, USA. hmaecker@cmgm.stanford.edu; Mice lacking CD81 (TAPA-1), a widely expressed tetraspanin molecule, have impaired antibody responses to protein antigens. This defect is specific to antigens that preferentially stimulate a T helper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with T cell-dependent antigens. Absence of
Two distinct pathways of positive selection for thymocytes.: Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2486-91. Unique Identifier : AIDSLINE MED/98151539; Akashi K; Kondo M; Weissman IL; Departments of Pathology and Developmental Biology, Stanford; University School of Medicine, Stanford, CA 94305, USA.; Akashi@Darwin.Stanford.edu; Most mouse thymocytes undergoing positive selection are found on one of two pathways; the c-Kit+ and the c-Kit- pathways. Here, we show that c-Kit and interleukin-7 receptor (IL-7R)-mediated signals support positive selection during the transition from the subpopulation that first expresses cell surface T cell recepto
Effects of feline immunodeficiency virus on astrocyte glutamate uptake: implications for lentivirus-induced central nervous system diseases.: Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2624-9. Unique Identifier : AIDSLINE MED/98151564; Yu N; Billaud JN; Phillips TR; Department of Neuropharmacology, The Scripps Research Institute, La; Jolla, CA 92037, USA.; Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats that causes a spectrum of diseases remarkably similar to AIDS in HIV-infected humans. As part of this spectrum, both HIV-1 and FIV induce neurologic disorders. Because astrocytes are essential in maintaining the homeostasis of the central nervous sys
Limited value of preoperative cervical vascular imaging in patients with velocardiofacial syndrome.: Plast Reconstr Surg. 1998 Apr;101(5):1184-95; discussion 1196-9. Unique Identifier : AIDSLINE MED/98188049; Witt PD; Miller DC; Marsh JL; Muntz HR; Grames LM; Department of Surgery, Plastic and Reconstructive, St. Louis; Children's Hospital, Washington University School of Medicine, MO; 63110, USA.; The purpose of this two-part study was to evaluate the safety of surgical management of speech production disorders in patients with velocardiofacial syndrome without preoperative cervical vascular imaging studies. Anomalous internal carotid arteries have been shown to be a frequent feature of velocardiofacial syndrom
[Characterization of fatty acids and mycolic acid degradation products in mycobacterial species of major incidence in Argentina]: Rev Argent Microbiol. 1997 Oct-Dec;29(4):184-94. Unique Identifier : AIDSLINE MED/98132725; Zerbini E; Cardoso M; Sequeira M; Taher H; Santi N; Larpin D; Latini O; Tonarelli G; Departamento de Quimica Organica, Facultad de Bioquimica y Ciencias; Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina.; The human immunodeficiency virus (HIV) epidemic has altered the epidemiological profile of tuberculosis in both industrialized and developing countries. Serious diseases caused by mycobacteria other that M. tuberculosis, mostly belonging to the M. avium-intracellulare complex (MAC), have become very common in associat
[Pubic tuberculous osteo-arthritis. Apropos of 2 cases]: Rev Chir Orthop Reparatrice Appar Mot. 1997;83(7):670-2. Unique Identifier : AIDSLINE MED/98176111; Benbouazza K; Allali F; Bezza A; el Hassani S; el Maghraoui A; Lazrak N; Hassouni F; Hajjaj-Hassouni N; Service de Rhumatologie B, CHU Rabat-Sale, Hopital El Ayachi, Sale,; Maroc.; OBJECTIVE: The authors report an exceptional site of tuberculous osteo-articular infection which must be diagnosed before the destructive stage. OBSERVATIONS: Case 1 : a 21 years old woman presented an inflammatory pubic pain after a trauma with weight loss of 4 kgs in 3 weeks. She presented also 2 satellite inguinal
[Occupational accidents with exposure to biological fluids. Recommendations for the management of exposed workers]: Rev Med Chil. 1997 May;125(5):605-13. Unique Identifier : AIDSLINE MED/98159013; Wolff M; Departamento de Medicina, Facultad de Medicina, Universidad de Chile,; Hospital San Borja Arriaran, Santiago de Chile.; Health Care Workers (HCW) are continually exposed to body fluids from patients. Some of these fluids may carry pathogens potentially transmissible to HCWs if the exposure is considered to be of high risk (mainly percutaneous exposure). The main agents that have been transmitted by occupational exposure are hepatitis
The current status of methods for estimating the prevalence of human immunodeficiency virus in the United States of America.: Stat Med. 1998 Jan 30;17(2):127-42. Unique Identifier : AIDSLINE MED/98144718; Karon JM; Khare M; Rosenberg PS; Division of HIV/AIDS Prevention-Surveillance and Epidemiology E-48),; National Center for HIV, STD and TB Prevention, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; The prevalence of human immunodeficiency virus (HIV) infection can be estimated by two distinct methods. One method, back-calculation, is a complex statistical procedure that estimates the HIV epidemic curve. The second method is based on data from population-based surveys, which provide estimates of the proportion of
Using surveillance data to monitor trends in the AIDS epidemic.: Stat Med. 1998 Jan 30;17(2):143-54. Unique Identifier : AIDSLINE MED/98144719; Green TA; Division of AIDS, STD, and TB Laboratory Research, National Center for; Infectious Diseases, Centers for Disease Control and Prevention,; Public Health Service, Department of Health and Human Services,; Atlanta, GA 30333, USA. tag1@cdc.gov; Series of incident cases of acquired immunodeficiency syndrome AIDS) must be adjusted before being used to evaluate trends in AIDS incidence or to estimate the current prevalence of the human immunodeficiency virus (HIV). This paper describes adjustments that account for delays in reporting AIDS cases, the lack of HIV
Estimating the cumulative incidence of HIV infection among persons with haemophilia in the United States of America.: Stat Med. 1998 Jan 30;17(2):155-68. Unique Identifier : AIDSLINE MED/98144720; Rosenberg PS; Goedert JJ; National Cancer Institute, Rockville, MD 20852, USA.; philip-rosenberg@nih.gov; We used complementary approaches to estimate the cumulative incidence of infection with the human immunodeficiency virus HIV) among persons with haemophilia in the United States of America. One approach, ratio estimation, divided the cumulative number of haemophiliacs diagnosed with ac
Projection of AIDS and HIV incidence among children born infected with HIV.: Stat Med. 1998 Jan 30;17(2):169-81. Unique Identifier : AIDSLINE MED/98144721; Byers RH Jr; Caldwell MB; Davis S; Gwinn M; Lindegren ML; Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.; By 31 December 1995, 6285 children with perinatally acquired immunodeficiency syndrome (AIDS) had been reported to the Centers for Disease Control and Prevention (CDC) by the state and local health departments of all 50 states, the District of Columbia, Puerto Rico , and the U.S
Augmented HIV vaccine trial design for estimating reduction in infectiousness and protective efficacy.: Stat Med. 1998 Jan 30;17(2):185-200. Unique Identifier : AIDSLINE MED/98144722; Datta S; Halloran ME; Longini IM Jr; Department of Biostatistics, Rollins School of Public Health, Emory; University, Atlanta, GA 30322, USA.; It is important to design HIV vaccine trials to estimate the efficacy of a vaccine in reducing infectiousness in addition to the protective efficacy. Currently planned phase III HIV vaccine field trials in which at-risk individuals are randomized and followed over time do not permit estimation or testing of the vaccin
Tutorial in biostatistics methods for interval-censored data.: Stat Med. 1998 Jan 30;17(2):219-38. Unique Identifier : AIDSLINE MED/98144724; Lindsey JC; Ryan LM; Department of Biostatistics, Harvard School of Public Health, Boston,; MA 02115, USA.; In standard time-to-event or survival analysis, occurrence times of the event of interest are observed exactly or are right-censored, meaning that it is only known that the event occurred after the last observation time. There are numerous methods available for estimating the survival curve and for testing and estimat
Laboratory technologists' attitudes towards AIDS and AIDS patients.: Scand J Caring Sci. 1997;11(4):212-6. Unique Identifier : AIDSLINE MED/98166627; Liikanen E; Aavarinne H; North Karelia Polytechnic, Joensuu, Finland.; The purpose of this study was to examine the attitudes of laboratory staff towards AIDS and AIDS patients and related factors. The population consisted of the working-age laboratory technologists living in Finland (n = 5,973). A sam
[Nursing care plans for Mr. Claude C]: Rev Infirm. 1997 Dec;(33):46-50. Unique Identifier : AIDSLINE MED/98144056; Hivet-Sadoine V; Novak S
Down-regulation of lymphokine synthesis by intravenous gammaglobulin is dependent upon accessory cells.: Scand J Immunol. 1998 Mar;47(3):229-35. Unique Identifier : AIDSLINE MED/98178676; Skansen-Saphir U; Andersson J; Bjork L; Ekberg C; Fehniger TE; Henter JI; Andersson U; Department of Pediatrics, St. Goran's Children's Hospital, Stockholm; University, Sweden.; We have investigated one mechanism by which pooled human IgG preparations for intravenous use (i.v.Ig) selectively down-regulates lymphokine synthesis. Effects of i.v.Ig on cytokine production were quantified at a cellular level by using an immunocytochemical staining technique. Pure T-lymphocyte preparations (from th
Association of HLA B27 with benign clinical course of nephropathia epidemica caused by Puumala hantavirus.: Scand J Immunol. 1998 Mar;47(3):277-9. Unique Identifier : AIDSLINE MED/98178682; Mustonen J; Partanen J; Kanerva M; Pietila K; Vapalahti O; Pasternack A; Vaheri A; Medical School, University of Tampere and Tampere University Hospital,; Finland.; Both the severe course of nephropathia epidemica (NE) caused by Puumala hantavirus, and the fast progression of human immunodeficiency virus (HIV) disease, are associated with the HLA B8 DRB1*0301 haplotype. As HLA B27, on the contrary, is associated with the slow progression of HIV disease, we wanted to test whether
Exploring how to get at--and eradicate--hidden HIV [news]: Science. 1998 Mar 20;279(5358):1854-5. Unique Identifier : AIDSLINE MED/98201880; Cohen J
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.: Science. 1998 Mar 27;279(5359):2103-6. Unique Identifier : AIDSLINE MED/98182444; Ogg GS; Jin X; Bonhoeffer S; Dunbar PR; Nowak MA; Monard S; Segal JP; Cao Y; Rowland-Jones SL; Cerundolo V; Hurley A; Markowitz M; Ho DD; Nixon DF; McMichael AJ; Institute of Molecular Medicine, Nuffield Department of Medicine,; Oxford OX3 9DS, UK.; Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human immunodeficiency virus-type 1 HIV-1) infection, it has not been possible to demonstrate a direct relation between CTL activity and plasma RNA viral load. Human leukocyte antigen-peptide tetrameric complexes offer a specific mean
"Survivors" and "victims": long-term HIV positive individuals and the ethos of self-empowerment.: Soc Sci Med. 1997 Dec;45(12):1863-73. Unique Identifier : AIDSLINE MED/98108936; Crossley ML; Edge-Hill University College, Ormskirk, Lancashire, U.K.; Recent research on contemporary processes of self-construction has suggested that the concepts of self , health , morality and responsibility have become inextricably interconnected, to the extent that the pursuit of health has become the pursuit of moral personhood [R. Crawford (1994) The boundaries of the se
HIV/AIDS-related social anxieties in adolescents in three African countries.: Soc Sci Med. 1998 Feb;46(3):313-20. Unique Identifier : AIDSLINE MED/98122145; Venier JL; Ross MW; Akande A; Center for Health Promotion Research and Development, School of Public; Health, University of Texas, Houston 77225, USA.; This study examines the social anxieties associated with HIV prevention in adolescents in three African countries ( Nigeria , Kenya , and Zimbabwe ). The subjects used in this study were black Africans in form
Is there evidence for behaviour change in response to AIDS in rural Zimbabwe?: Soc Sci Med. 1998 Feb;46(3):321-30. Unique Identifier : AIDSLINE MED/98122146; Gregson S; Zhuwau T; Anderson RM; Chandiwana SK; Wellcome Trust Centre for the Epidemiology of Infectious Disease,; Zoology Department, Oxford University, U.K.; This article reports on evidence for behaviour change in response to AIDS among women in two rural areas of Manicaland Province, Zimbabwe . It examines self-reported data on two overlapping areas of behaviour: (1) actions taken to avoid HIV-1 infection; and (2) fertility practices
[HIV-associated Kaposi sarcoma of the nasal cavities oral cavities]: Rontgenpraxis. 1997 Dec;50(12):342-5. Unique Identifier : AIDSLINE MED/98153433; Elsner K; Kolokythas O; Nussle K; Keck AM; Abteilung fur Diagnostische Radiologie, Uiversitatsklinik Ulm.
Adrenocortical response and regional T-lymphocyte activation patterns following minimally invasive surgery in a rat model.: Surg Endosc. 1998 Mar;12(3):236-40. Unique Identifier : AIDSLINE MED/98169573; Berguer R; Dalton M; Ferrick D; Department of Surgery, University of California Davis, 4301 X Street,; Sacramento, CA 95817, USA.; BACKGROUND: Laparoscopic surgery is associated with less tissue trauma and postoperative pain as well as a more rapid recovery than open surgery. We hypothesized that these factors may result in less immune impairment following laparoscopic surgery. METHODS: We measured mitogen-induced surface interleukin-2 receptor (
Royal Society of Tropical Medicine and Hygiene meeting at Manson House, London, 12 December 1996. HIV and pneumococcal infection in Africa. Clinical, epidemiological and preventative aspects.: Trans R Soc Trop Med Hyg. 1997 Nov-Dec;91(6):627-31. Unique Identifier : AIDSLINE MED/98169901; Gilks CF; Liverpool School of Tropical Medicine, UK. gilks@liverpool.ac.uk; The pneumococcus (Streptococcus pneumoniae) is a leading cause of morbidity and mortality in tropical and temperate climes. Despite being well recognized as an important pathogen associated with human immunodeficiency virus (HIV) infection in industrialized countries, this interaction has received little attention in
Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 12 December 1996. HIV and pneumococcal infection in Africa. Microbiological aspects.: Trans R Soc Trop Med Hyg. 1997 Nov-Dec;91(6):632-7. Unique Identifier : AIDSLINE MED/98169902; Paul J; Brighton Public Health Laboratory, Royal Sussex County Hospital, UK.; By the 1930s several studies had shown that Streptococcus pneumoniae was an important pathogen in Nairobi ( Kenya ) and various risk factors for infection were recognized, including seasonally cold conditions, overcrowding and recent arrival in the city. Research into pneumococcal dis
HIV testing and tuberculosis treatment outcome in a rural district in Malawi.: Trans R Soc Trop Med Hyg. 1997 Nov-Dec;91(6):707-8. Unique Identifier : AIDSLINE MED/98169923; Banerjee A; Moyo S; Salaniponi F; Harries A; Ntcheu District Hospital, Central Region, Malawi.
Organ donor screening for infectious diseases: review of practice and implications for transplantation.: Transplantation. 1998 Mar 15;65(5):603-10. Unique Identifier : AIDSLINE MED/98180486; Delmonico FL; Snydman DR; Department of Surgery, Harvard Medical School, Massachusetts General; Hospital, Boston, USA.
Humanized IgG1 and IgG4 anti-CD4 monoclonal antibodies: effects on lymphocytes in the blood, lymph nodes, and renal allografts in cynomolgus monkeys.: Transplantation. 1998 Mar 15;65(5):632-41. Unique Identifier : AIDSLINE MED/98180491; Mourad GJ; Preffer FI; Wee SL; Powelson JA; Kawai T; Delmonico FL; Knowles RW; Cosimi AB; Colvin RB; Massachusetts General Hospital, and the Department of Pathology,; Harvard Medical School, Boston 02114, USA.; BACKGROUND: Optimizing therapeutic monoclonal antibody (mAb) depends on the incorporation of the necessary effector functions and the development of hypoantigenic humanized antibodies by genetic engineering, which then need to be tested in appropriate preclinical trials. METHODS: Constructs of humanized OKT4A contai
Epstein-Barr virus and primary lymphoma of the central nervous system in immunodeficient patients [letter]: Tumori. 1997 Nov-Dec;83(6):960-1. Unique Identifier : AIDSLINE MED/98187341; Coli A; Bigotti G
[Digestive parasitic diseases. A continuous current problem]: Tunis Med. 1995 Jan;73(1):53-6. Unique Identifier : AIDSLINE MED/98167023; Chaker E; Bel Hadj S; Khaled S; Ben Moussa M; Ben Rachid MS; Laboratoire de parasitologie, CHU La Rabta, Tunis.
[HIV infection and autoantibodies]: Tunis Med. 1995 Dec;73(12):531-6. Unique Identifier : AIDSLINE MED/98167033; Makni S; Limam R; Zitouni M; Gorgi Y; Slim A; Arrouji Z; Rejeb SB; Ayed KH; Laboratoire d'immunologie, Hopital Charles Nicolle.
[Mucocutaneous manifestations in the course of HIV infection: a retrospective study of 120 patients]: Tunis Med. 1997 Jan;75(1):31-4. Unique Identifier : AIDSLINE MED/98166918; Mokni M; Damak A; Ben Osman A; Ben Salem N; Zribi A; Service de dermatologie, Hopital la Rabta.
A minimally replicative HIV-2 live-virus vaccine protects M. nemestrina from disease after HIV-2(287) challenge.: Virology. 1998 Mar 1;242(1):150-60. Unique Identifier : AIDSLINE MED/98162577; Looney DJ; McClure J; Kent SJ; Radaelli A; Kraus G; Schmidt A; Steffy K; Greenberg P; Hu SL; Morton WR; Wong-Staal F; Infectious Diseases, VA San Diego Healthcare System, California 92161,; USA. dlooney@ucsd.edu; M. nemestrina immunized with an apathogenic HIV-2 molecular clone HIV-2KR) were protected from CD4 decline and disease upon challenge with HIV-2(287), after any immunizing virus could be detected. Higher but not lower inocula of HIV-2KR were protective against intravenous inoculation of either 10(5) or 10(1) TCID50 of
Increased ratio of bcl-2/bax expression is associated with bovine leukemia virus-induced leukemogenesis in cattle.: Virology. 1998 Mar 1;242(1):184-92. Unique Identifier : AIDSLINE MED/98162580; Reyes RA; Cockerell GL; Department of Pathology, College of Veterinary Medicine and Biomedical; Sciences, Colorado State University, Fort Collins 80523-1671, USA.; To further investigate the molecular basis underlying the dysregulation of B cell homeostasis associated with bovine leukemia virus disease progression in cattle, bovine bax was cDNA cloned and sequenced. The predicted amino acid sequence of bovine Bax revealed a 192-amino-acid protein having extensive identity with t
Inhibition of HIV-1 replication by a monoclonal antibody directed toward the complementarity determining region 3-like domain of CD4 in CD45 expressing and CD45-deficient cells.: Virology. 1998 Mar 1;242(1):233-7. Unique Identifier : AIDSLINE MED/98162585; Peleraux A; Peyron JF; Devaux C; Laboratoire d'Immunologie des Infections Retrovirales, Centre de; Recherches de Biologie Macromoleculaire CNRS ERS 155, Montpellier,; France.; Monoclonal antibodies directed toward the complementarity determining region (CDR)3-like loop of the aminoterminal domain of CD4 have been shown to inhibit the replication of human immunodeficiency virus (HIV) in CD4 positive T cells. The mechanism of action of these antibodies is not yet elucidated, although several
Practical issues regarding the use of antiretroviral therapy for HIV infection.: West J Med. 1998 Feb;168(2):133-9. Unique Identifier : AIDSLINE MED/98160733; Deeks SG; University of California, School of Medicine, San Francisco 94110,; USA. sdeeks@sfaids.ucsf.edu; With the recent development of potent new antiretroviral therapies, the management of HIV infection has become increasingly complex. There are now 12 antiretroviral drugs approved for use in the management of HIV infection, with several more in the advanced stages of clinical development. Staying current with this rap
Association of methamphetamine use during sex with risky sexual behaviors and HIV infection among non-injection drug users.: West J Med. 1998 Feb;168(2):93-7. Unique Identifier : AIDSLINE MED/98160721; Molitor F; Truax SR; Ruiz JD; Sun RK; Office of AIDS, Department of Health Services, Sacramento, CA; 94234-7320, USA. fmolitor@hw1.cahwnet.gov; Morbidity, mortality, and drug treatment data suggest that methamphetamine use is on the rise. Based on research findings of the sexual behaviors of methamphetamine-using injection drug users, we chose to examine the relationship between methamphetamine use during sex and risky sexual behaviors and human immunodeficie
Chemotherapy in patients with acquired immunodeficiency virus syndrome associated with non-Hodgkin's lymphoma.: Wien Klin Wochenschr. 1998 Jan 16;110(1):15-9. Unique Identifier : AIDSLINE MED/98160448; Fridrik MA; Geit M; Wahl G; Ehrengruber A; Simma R; Hopfel I; Bettelheim P; Leisch F; Department of Medicine, A. o. Krankenhaus Linz, Austria.; We retrospectively analyzed our chemotherapy results in patients with the Acquired Immunodeficiency Virus syndrome (AIDS) and lymphoma over a 10 year period. Thirty out of 492 (6%) Human Immunodeficiency Virus (HIV) positive patients developed a non-Hodgkin s lymphoma . Thirteen pat
[Anitha is healthy! (interview by Inger Jalakas)]: Vardfacket. 1998 Jan 12;22(1):28. Unique Identifier : AIDSLINE MED/98189113; Sunsiri M
Knowledge about AIDS and follow-up compliance in patients attending a sexually transmitted disease clinic in the highlands of Papua New Guinea.: P N G Med J. 1995 Sep;38(3):178-90. Unique Identifier : AIDSLINE MED/98183458; Kramer PB; Porgera Health Centre, Enga Province, Papua New Guinea.; In a survey of 300 consecutive new attenders at the Porgera Health Centre Sexually Transmitted Disease Clinic information was obtained regarding knowledge about AIDS from male and female attenders. The differences between the sexes regarding a variety of socioeconomic variables, knowledge about AIDS and their complian
Gastrointestinal nematodes: the Karkar experience.: P N G Med J. 1995 Dec;38(4):295-9. Unique Identifier : AIDSLINE MED/98183472; Pritchard DI; Department of Life Sciences, University of Nottingham, England, UK.; This paper reviews our research on the hookworm Necator americanus over several years. Our field site for the research was on Karkar Island, Papua New Guinea , where we found a prevalence of N. americanus infection among adults of ne
Papua New Guinea Red Cross Blood Transfusion Service: present status and future considerations.: P N G Med J. 1996 Mar;39(1):38-42. Unique Identifier : AIDSLINE MED/98183450; Tozer RA; Papua New Guinea Red Cross Blood Transfusion Service, Boroko, Papua; New Guinea.; About 28,000 units of blood are collected per annum. This is adequate for present needs. 11 donors have been found positive for human immunodeficiency virus (HIV) since testing started in 1987, 8 of these in the last year and a half. No case of transmission of HIV by transfusion in
[Germinal tumor of the testis and acquired immunodeficiency syndrome]: Actas Urol Esp. 1997 Nov-Dec;21(10):978-80. Unique Identifier : AIDSLINE MED/98155267; Carrasco Canovas N; Carles Galceran J; Nohales Taurines G; Arango Toro O; Cortadellas Angel R; Bielsa Gali O; Gelabert Mas A; Servicio y Catedra de Urologia, Hospital Universitario del Mar,; Barcelona.; Over the last few years a number of testicular tumours in seropositive patients or patients with AIDS-diagnostic factors have been described in the literature with no clear relationship having been established between both conditions. Most authors believe management should not differ from that being given to non-immun
Primary mediastinal germ cell tumor in HIV infection [letter]: Am Fam Physician. 1998 Mar 1;57(5):946-7. Unique Identifier : AIDSLINE MED/98179448; Ahmed M; Bhagat B; Anigbogu J; Khine M
Pregnancy is not associated with the progression of HIV disease in women attending an HIV outpatient program.: Am J Epidemiol. 1998 Mar 1;147(5):434-40. Unique Identifier : AIDSLINE MED/98184441; Bessinger R; Clark R; Kissinger P; Rice J; Coughlin S; Department of Biostatistics and Epidemiology, Tulane University School; of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.; The objective of this study was to determine whether pregnancy is associated with an acceleration of human immunodeficiency virus HIV) disease progression in women who have a pregnancy while HIV infected. A retrospective review of all women aged 15-35 years who attended an HIV outpatient program from January 1989 thro
Use of neural networks to model complex immunogenetic associations of disease: human leukocyte antigen impact on the progression of human immunodeficiency virus infection.: Am J Epidemiol. 1998 Mar 1;147(5):464-71. Unique Identifier : AIDSLINE MED/98184445; Ioannidis JP; McQueen PG; Goedert JJ; Kaslow RA; HIV Research Branch, Division of AIDS, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; Complex immunogenetic associations of disease involving a large number of gene products are difficult to evaluate with traditional statistical methods and may require complex modeling. The authors evaluated the performance of feed-forward backpropagation neural networks in predicting rapid progression to acquired immu
Randomized trial of itraconazole oral solution for oropharyngeal candidiasis in HIV/AIDS patients.: Am J Med. 1998 Jan;104(1):33-9. Unique Identifier : AIDSLINE MED/98187566; Graybill JR; Vazquez J; Darouiche RO; Morhart R; Greenspan D; Tuazon C; Wheat LJ; Carey J; Leviton I; Hewitt RG; MacGregor RR; Valenti W; Restrepo M; Moskovitz BL; Audie Murphy VA Hospital, San Antonio, Texas 78284, USA.; PURPOSE: Oropharyngeal candidasis ( thrush ) is the most common opportunistic infection in individuals who are positive for the human immunodeficiency virus (HIV) and those who have progressed to AIDS. Itraconazole has a broad in vitro spectrum of activity, including a wide varie
Granulocyte colony-stimulating factor use is associated with decreased bacteremia and increased survival in neutropenic HIV-infected patients.: Am J Med. 1998 Jan;104(1):48-55. Unique Identifier : AIDSLINE MED/98187568; Keiser P; Rademacher S; Smith JW; Skiest D; Vadde V; University of Texas Southwestern Medical Center, The Department of; Veterans Affairs Medical Center, Dallas 75216, USA.; BACKGROUND: Neutropenia occurs in up to 17% of human immunodeficiency virus (HIV)-infected individuals. Although granulocyte colony-stimulating factor (G-CSF) can reverse HIV-related neutropenia, it is not established that this therapy can reduce bacterial infections and affect survival. METHODS: A retrospective cohor
The yield of bone marrow biopsy and culture compared with blood culture in the evaluation of HIV-infected patients for mycobacterial and fungal infections.: Am J Med. 1998 Feb;104(2):123-8. Unique Identifier : AIDSLINE MED/98187578; Kilby JM; Marques MB; Jaye DL; Tabereaux PB; Reddy VB; Waites KB; Department of Medicine, University of Alabama at Birmingham,; 35294-2050, USA.; PURPOSE: To compare the clinical utility of bone marrow biopsy and culture specimens with blood cultures for mycobacterial and fungal infections among human immunodeficiency virus HIV)-infected patients. PATIENTS AND METHODS: All bone marrow biopsies obtained from HIV-infected patients at the University of Alabama at
Constitutional symptoms and health-related quality of life in patients with symptomatic HIV disease.: Am J Med. 1998 Feb;104(2):129-36. Unique Identifier : AIDSLINE MED/98187579; Cunningham WE; Shapiro MF; Hays RD; Dixon WJ; Visscher BR; George WL; Ettl MK; Beck CK; Department of Medicine, University of California at Los Angeles, USA.; PURPOSE: To assess the severity of constitutional symptoms in persons with human immunodeficiency virus (HIV) infection, and their relationship to health-related quality of life (HRQOL). PATIENTS AND METHODS: Two hundred five HIV-infected patients (93% male, 26% African American, 28% Latino, 39% white, 7% other ethnic
The influence of program acceptability on the effectiveness of public health policy: a study of directly observed therapy for tuberculosis.: Am J Public Health. 1998 Mar;88(3):442-5. Unique Identifier : AIDSLINE MED/98179482; Heymann SJ; Sell R; Brewer TF; Department of Health and Social Behavior, Harvard School of Public; Health, Boston, MA 02115, USA.; OBJECTIVES: This study examined how patient acceptability influences the effectiveness of directly observed therapy for tuberculosis. METHODS: Decision and sensitivity analyses were used in assessing influences. RESULTS: If mandatory directly observed therapy discourages 6% of initial tuberculosis patients range: 4% t
Kaposi's sarcoma of the parotid gland in acquired immunodeficiency syndrome.: Am Surg. 1998 Mar;64(3):259-60. Unique Identifier : AIDSLINE MED/98181436; Mukherjee A; Silver CE; Rosario PG; Gerst PH; Department of Surgery, Montefiore Medical Center, Bronx, New York,; USA.; Parotid gland enlargement is common in patients infected with the human immunodeficiency virus. Although parotitis is the usual histopathological feature in such cases, patients with acquired immunodeficiency syndrome are at high risk of developing both lymphoma and Kaposi s sarcoma of the parotid gland. Human immunod
Biological and virologic characteristics of primary HIV infection.: Ann Intern Med. 1998 Apr 15;128(8):613-20. Unique Identifier : AIDSLINE MED/98196589; Schacker TW; Hughes JP; Shea T; Coombs RW; Corey L; University of Washington and the Fred Hutchinson Cancer Research; Center, Seattle 98104, USA.; BACKGROUND: The clinical events surrounding acute HIV-1 infection have been well described, but little is known about whether the virologic course of acute HIV-1 infection influences the subsequent progression of disease. OBJECTIVE: To define the virologic natural history of acute and very early HIV infection. DESIGN:
Quantitative assessment of hepatitis B virus DNA during a 24-week course of lamivudine therapy [letter]: Ann Intern Med. 1998 Apr 15;128(8):697. Unique Identifier : AIDSLINE MED/98196608; Honkoop P; de Man RA; Niesters HG
Hormone-induced acneiform eruption in human immunodeficiency virus disease [letter]: Arch Dermatol. 1998 Mar;134(3):374-6. Unique Identifier : AIDSLINE MED/98180336; Kwon PS; Maurer T; LeBoit PE; Aly R; Berger TG
Dyspnoea in an adult with HIV infection: a rare cause [letter]: Aust N Z J Med. 1997 Dec;27(6):711. Unique Identifier : AIDSLINE MED/98144238; Paull AE; O'Reilly MA; Stanley PA
Studies on inhibitors of mammalian DNA polymerase alpha and beta: sulfolipids from a pteridophyte, Athyrium niponicum.: Biochem Pharmacol. 1998 Feb 15;55(4):537-41. Unique Identifier : AIDSLINE MED/98173023; Mizushina Y; Watanabe I; Ohta K; Takemura M; Sahara H; Takahashi N; Gasa S; Sugawara F; Matsukage A; Yoshida S; Sakaguchi K; Department of Applied Biological Science, Science University of Tokyo,; Japan.; Three sulfolipid compounds, 1, 2, and 3, have been isolated from a higher plant, a pteridophyte, Athyrium niponicum, as potent inhibitors of the activities of calf DNA polymerase alpha and rat DNA polymerase beta. The inhibition by the sulfolipids was concentration dependent, and almost complete inhibition of DNA poly
Retention of marked sensitivity to S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-di hydroquin oxaline-2(1H)-thione (HBY 097) by an azidothymidine AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2',3'-dideoxy-3'-thiacytidine (lamivudine).: Biochem Pharmacol. 1998 Mar 1;55(5):617-25. Unique Identifier : AIDSLINE MED/98175323; Balzarini J; Pelemans H; Riess G; Roesner M; Winkler I; De Clercq E; Kleim JP; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium. Jan.Balzarine@rega.kuleuven.ac.be; An azidothymidine ( AZT )-resistant virus strain (HIV-1/AZT) containing the 67 Asp --> Asn, 70 Lys --> Arg, 215 Thr --> Phe and 219 Lys --> Gln mutations into its reverse transcriptase) was grown in the combined presence of 2 ,3 -dideoxy-3 -thiacytidine
Synthesis and biological investigations of 2-(tetrahydropyran-2'-yl) and 2-(tetrahydrofuran-2'-yl)benzimidazoles.: Farmaco. 1997 Aug-Sep;52(8-9):499-507. Unique Identifier : AIDSLINE MED/98168501; Novelli F; Tasso B; Sparatore F; Sparatore A; Dipartimento di Scienze Farmaceutiche, Universita di Genova, Italy.; A set of benzimidazole derivatives bearing on position 2 a tetrahydropyranyl or tetrahydrofuranyl residue was prepared and tested for antitumoral, anti HIV-1 and other pharmacological activities. While the anti-HIV activity was completely lacking, moderate antitumoral activity was found in a few compounds; particularl
Synthesis and biological investigations of 1-(tetrahydropyran-2'-yl)- and 1-(tetrahydrofuran-2'-yl)benzimidazoles and 1/2-(tetrahydropyran-2'-yl)- and 1/2-(tetrahydrofuran-2'-yl)benzotriazoles.: Farmaco. 1997 Aug-Sep;52(8-9):509-21. Unique Identifier : AIDSLINE MED/98168502; Sparatore A; Novelli F; Sparatore F; Istituto Chimico Farmaceutico e Tossicologico, Universita di Milano,; Italy.; Sets of benzimidazole and benzotriazole derivatives bearing on position 1 or 2 a tetrahydrofuranyl or tetrahydropyranyl moieties were prepared through the addition of the suitable benzazoles on 2,3-dihydrofuran and 3,4-dihydro-2H-pyran. The reactions were carried on either without solvent or in carbon tetrachloride so
Quinoxaline chemistry. Part 8. 2-[Anilino]-3-[carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity.: Farmaco. 1997 Aug-Sep;52(8-9):531-7. Unique Identifier : AIDSLINE MED/98168504; Loriga M; Moro P; Sanna P; Paglietti G; Zanetti S; Istituto di Chimica Farmaceutica, Universita di Sassari.; Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhi
Gene vaccination: plasmid DNA is more than just a blueprint.: Immunol Today. 1998 Feb;19(2):89-97. Unique Identifier : AIDSLINE MED/98170504; Tighe H; Corr M; Roman M; Raz E; Dept of Medicine, University of California, San Diego 92093-0663, USA.; htighe@ucsd.edu
Immunotherapy: natural versus synthetic peptides [letter]: Immunol Today. 1998 Feb;19(2):98. Unique Identifier : AIDSLINE MED/98170506; Protti MP; Bellone M
Single cell analyses of cytokine production.: Curr Opin Immunol. 1997 Apr;9(2):177-82. Unique Identifier : AIDSLINE MED/98145601; Carter LL; Swain SL; Trudeau Institute, New York, NY 12983, USA.; Subsets of T lymphocytes have been defined by their secretion of polarized patterns of cytokines. Type 1 and Type 2 subsets have been characterized in a variety of model systems both in vivo and in vitro and are a useful framework for studying immune responses. Recent technical advances have made it possible to analyz
Positive selection of T cells: fastidious or promiscuous?: Curr Opin Immunol. 1997 Apr;9(2):245-9. Unique Identifier : AIDSLINE MED/98145612; Benoist C; Mathis D; Institut de Genetique et de Biologie Moleculaire et Cellulaire; CNRS/INSERM/ULP), Strasbourg, France.; Several studies reported during the past year, most of which exploited novel in vivo positive selection systems, have addressed the basis of peptide involvement in positive selection of T cells. The very flexible, yet specific, requirements the studies demonstrate differ somewhat from the very specific requirements re
T cells and cytokines in Crohn's disease.: Curr Opin Immunol. 1997 Dec;9(6):793-9. Unique Identifier : AIDSLINE MED/98154000; Romagnani P; Annunziato F; Baccari MC; Parronchi P; Department of Physiopathology, Institute of Internal Medicine,; University of Florence, Italy.; Recent findings indicate that activated T lymphocytes, showing restricted T-cell receptor repertoire and a Th1-like profile of cytokine production, are responsible for macrophage activation and release of inflammatory cytokines, toxic oxygen metabolites and nitric oxide, which initiate and maintain the transmural inte
Allergen gene transfer.: Curr Opin Immunol. 1997 Dec;9(6):800-4. Unique Identifier : AIDSLINE MED/98154001; Huang SK; Chua KY; Hsieh KH; Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.; skhuang@welchlink.welch.jhu.edu; DNA-based immunization induces a biased Th1 immune response, and offers a novel strategy for modulation of the Th2-associated response. Recent studies have provided evidence that antigen-induced allergic responses can be modulated in rodents immunized with plasmid DNAs encoding the sensitizing antigens. Further unders
Therapeutic potential of anti-IgE antibodies.: Curr Opin Immunol. 1997 Dec;9(6):805-13. Unique Identifier : AIDSLINE MED/98154002; Heusser C; Jardieu P; Pharmaceutical Research, Basel, Switzerland.; Christoph.Heusser@Pharma.Novartis.com; Anti-IgE antibodies directed against the Fc epsilon RI-binding region on IgE inhibit binding of IgE to IgE receptors without inducing mediator release from IgE sensitized cells. In mice these antibodies selectively reduce serum IgE, inhibit antigen induced skin reactions, cytokine production by lung Th2 cells, and pul
Mediators of inflammation.: Curr Opin Immunol. 1997 Dec;9(6):851-7. Unique Identifier : AIDSLINE MED/98154009; Sacca R; Cuff CA; Ruddle NH; Department of Epidemiology, Yale University School of Medicine, New; Haven, CT 06520-8034, USA.; Therapeutic studies and genetically engineered animals have elucidated the inflammatory roles of cytokines and chemokines in autoimmune disease. Most unexpected has been a continuum of recent evidence demonstrating that inflammatory mediators are crucial in lymphoid organ development, thus suggesting that these hither
Organ-specific autoimmunity.: Curr Opin Immunol. 1997 Dec;9(6):863-71. Unique Identifier : AIDSLINE MED/98154011; King C; Sarvetnick N; Department of Immunology, Scripps Research Institute, La Jolla, CA; 92037, USA.; The past year has seen advances in our understanding of the mechanisms that control the expression of organ-specific autoimmunity. Attempts to develop therapeutic strategies for the prevention of autoimmune disease have largely been based on deviation of the T-cell response away from an autoaggressive, pro-inflammator
Comparable sensitivity and specificity of nested PCR and single-stage PCR using a thermally activated DNA polymerase.: Biotechniques. 1998 Feb;24(2):222-4. Unique Identifier : AIDSLINE MED/98155823; Zimmermann K; Mannhalter JW; Department of Molecular Analysis of Infectious Processes, IMMUNO AG,; Vienna, Austria.
Effect of protease inhibitors on nucleoside analogue phosphorylation in vitro.: Br J Clin Pharmacol. 1998 Feb;45(2):164-7. Unique Identifier : AIDSLINE MED/98150795; Hoggard PG; Manion V; Barry MG; Back DJ; Department of Pharmacology and Therapeutics, University of Liverpool,; UK.; AIMS: Combination antiretroviral therapy for human immunodeficiency virus (HIV) infection now involves both nucleoside analogues and protease inhibitors . Since intracellular phosphorylation is essential for the activity of all the nucleoside analogues this study was
Antiretroviral therapy for patients with HIV disease.: Br J Clin Pharmacol. 1998 Mar;45(3):221-8. Unique Identifier : AIDSLINE MED/98176542; Barry M; Mulcahy F; Back DJ; Department of Pharmacology and Therapeutics, University of Liverpool,; UK.
Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma.: Br J Cancer. 1998 Mar;77(6):1021-4. Unique Identifier : AIDSLINE MED/98187700; Abels C; Karrer S; Baumler W; Goetz AE; Landthaler M; Szeimies RM; Department of Dermatology, University of Regensburg, Germany.; Indocyanine green (ICG) is clinically approved for the determination of liver function, cardiac output and plasma volume. In this pilot study, ICG was used as photosensitizer in combination with a diode laser to treat AIDS-associated Kaposi s sarcoma (KS) in three patients. Directly and up to 50 min after intravenous
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.: Biochemistry. 1998 Mar 17;37(11):3594-601. Unique Identifier : AIDSLINE MED/98191319; Lee CG; Gottesman MM; Cardarelli CO; Ramachandra M; Jeang KT; Ambudkar SV; Pastan I; Dey S; Laboratory of Cell Biology, National Cancer Institute, Bethesda,; Maryland 20892, USA.; The FDA approved HIV-1 protease inhibitors , ritonavir , saquinavir, and indinavir , are very effec
Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.: Biochemistry. 1998 Mar 17;37(11):3677-86. Unique Identifier : AIDSLINE MED/98191327; Lavie A; Konrad M; Brundiers R; Goody RS; Schlichting I; Reinstein J; Department of Physical Biochemistry, Max Planck Institute for; Molecular Physiology, Dortmund, Germany.; The crystal structure of yeast thymidylate kinase (TmpK) complexed with the bisubstrate inhibitor P1-(5 -adenosyl) P5-(5 -thymidyl) pentaphosphate (TP5A) was determined at 2.0 A resolution. In this complex, TmpK adopts a closed conformation with a region (LID) of the protein closing upon the substrate and forming a he
Do we still need a cohort study of women with HIV infection? [editorial]: Epidemiology. 1998 Mar;9(2):111-3. Unique Identifier : AIDSLINE MED/98165035; Cotton D
The Women's Interagency HIV Study. WIHS Collaborative Study Group.: Epidemiology. 1998 Mar;9(2):117-25. Unique Identifier : AIDSLINE MED/98165038; Barkan SE; Melnick SL; Preston-Martin S; Weber K; Kalish LA; Miotti P; Young M; Greenblatt R; Sacks H; Feldman J; New England Research Institutes, Watertown, MA, USA.; The Women s Interagency HIV Study comprises the largest U.S. cohort to date of human immunodeficiency virus (HIV)-seropositive women (N = 2,058) with a comparison cohort of seronegative women N = 568). The methodology, training, and quality assurance activities employed are described. The study population, enrolled be
[Attitude and structural barriers detected in primary care physicians towards treating patients with HIV/AIDS infection]: Aten Primaria. 1997 Nov 30;20(9):486-92. Unique Identifier : AIDSLINE MED/98138119; Suarez-Varela Ubeda JF; Zunzunegui MV; Bimbela JL; Vilches A; Escuela Andaluza de Salud Publica, Granada.; OBJECTIVES: To identify attitudes, knowledge and self-perceived risks among doctors in the Este-Oriente District of Sevilla concerning HIV/AIDS infection; to detect attitude problems and structural barriers affecting doctors predisposition towards patients with HIV/AIDS infection. DESIGN: A cross sectional study usin
Cytokine profiles of in vivo activated thyroid-infiltrating T cells cloned in the presence or absence of interleukin 4.: Autoimmunity. 1997;26(2):103-10. Unique Identifier : AIDSLINE MED/98140618; Guo J; Rapoport B; McLachlan SM; Thyroid Molecular Biology Unit, Veterans' Administration Medical; Center and the University of California, San Francisco 94121, USA.; We compared Th1 and Th2 cytokines secreted by randomly selected, intrathyroidal CD4+ T cell clones isolated from a patient with Graves disease using IL-4 + IL-2 versus IL-2 alone. Prior to T cell isolation, PCR of cDNA from the intact thyroid tissue generated IL-4 and
Human T-cell leukemia virus type II directly acts on CD34+ hematopoietic precursors by increasing their survival potential. envelope-associated HLA class II molecules reverse this effect.: Blood. 1998 Apr 1;91(7):2296-304. Unique Identifier : AIDSLINE MED/98182292; Casoli C; Re MC; Monari P; Furlini G; Tosi G; Gradozzi C; Dall'Aglio PP; Bertazzoni PP; Accolla RS; Institute of Medical Pathology, University of Parma, Parma, Italy.; The role of human T-cell leukemia virus type II (HTLV-II) in human lymphoproliferative and hematopoietic abnormalities in which the retrovirus can be isolated is still elusive. Here we show that the C344 T-cell-derived lymphotropic HTLV-II type IIa Mo strain acts directly on CD34+ hematopoietic precursors by rescuing
Idiotype immunization combined with granulocyte-macrophage colony-stimulating factor in myeloma patients induced type I, major histocompatibility complex-restricted, CD8- and CD4-specific T-cell responses.: Blood. 1998 Apr 1;91(7):2459-66. Unique Identifier : AIDSLINE MED/98182311; Osterborg A; Yi Q; Henriksson L; Fagerberg J; Bergenbrant S; Jeddi-Tehrani M; Ruden U; Lefvert AK; Holm G; Mellstedt H; Department of Oncology, Karolinska Hospital, Swedish Institute for; Infectious Disease Control, Stockholm, Sweden.; Idiotypic structures expressed on the myeloma Ig protein might be regarded as a tumor-specific antigen. Five patients with IgG myeloma were immunized with the purified serum M-component by repeated intradermal injections together with soluble granulocyte-macrophage colony-stimulating factor (GM-CSF). All patients deve
Enhanced MDR1 gene expression in human T-cell leukemia virus-I-infected patients offers new prospects for therapy.: Blood. 1998 Apr 1;91(7):2467-74. Unique Identifier : AIDSLINE MED/98182312; Lau A; Nightingale S; Taylor GP; Gant TW; Cann AJ; Department of Microbiology and Immunology, University of Leicester,; Leicester, LE1 9HN, United Kingdom.; Overexpression of P-glycoprotein (P-gp), the protein product of the multidrug resistance gene (MDR1), confers a drug resistant phenotype on cells. This phenotype is reminiscent of human T-cell leukemia virus (HTLV)-transformed leukemic cells, for which no consistently effective chemotherapeutic regime has been found.
Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells.: Blood. 1998 Apr 1;91(7):2475-81. Unique Identifier : AIDSLINE MED/98182313; Asou H; Said JW; Yang R; Munker R; Park DJ; Kamada N; Koeffler HP; Division of Hematology/Oncology and Pathology, Cedars-Sinai Medical; Center, UCLA School of Medicine, Los Angeles, CA 90048, USA.; Primary effusion lymphoma (PEL) is a distinct clinicopathologic entity associated with Kaposi s sarcoma-associated herpes virus KSHV). Several cytokines, including interleukin-6 (IL-6), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF) may be important for survival of KS cells. However,
Analysis of signal transduction pathways in human eosinophils activated by chemoattractants and the T-helper 2-derived cytokines interleukin-4 and interleukin-5.: Blood. 1998 Apr 1;91(7):2547-57. Unique Identifier : AIDSLINE MED/98182321; Coffer PJ; Schweizer RC; Dubois GR; Maikoe T; Lammers JW; Koenderman L; Department of Pulmonary Diseases, University Hospital Utrecht,; Utrecht, The Netherlands.; Activation and recruitment of eosinophils in allergic inflammation is in part mediated by chemoattractants and T-helper 2 (Th2)-derived cytokines. However, little is known concerning the signal transduction mechanisms by which this activation occurs. We have investigated tyrosine kinase-mediated activation of phosphat
Risk factors for hepatotoxicity induced by antituberculosis drugs.: Acta Physiol Pharmacol Ther Latinoam. 1997;47(4):197-202. Unique Identifier : AIDSLINE MED/98164938; Devoto FM; Gonzalez C; Iannantuono R; Serra HA; Gonzalez CD; Saenz C; Department of Pharmacology, Faculty of Medicine, University of Buenos; Aires, Argentina. flamar@mail.interserver.com.ar; To evaluate the risk factors involved in antituberculosis treatment-induced hepatotoxicity. In a retrospective study we analyzed the rate of drug-induced hepatotoxicity in a sample of 456 patients. Patients received a combination of drugs including isoniazid, rifampin, pirazinamide and streptomycin or ethambutol. The
Different integrated and unintegrated HIV-1 DNA after superinfection and cell to cell transmission.: Acta Physiol Pharmacol Ther Latinoam. 1997;47(4):245-50. Unique Identifier : AIDSLINE MED/98164945; Marquina S; Libonatti O; Ceballos A; Gomez Carrillo M; Martinez Peralta L; Rabinovich RD; Departamento de Microbiologia, Facultad de Medicina, Universidad de; Buenos Aires, Argentina.; Efficient superinfection of H9HTLVIIIB cell line (persistently infected with HIVHXB2 strain) with HIVMN strain is reported. The superinfecting viral DNA was found in the chromosomic and extrachromosomic fractions at early stages, but at 48 hours post superinfection, it remained mainly unintegrated. Interestingly, supe
Short course of zidovudine cuts transmission of HIV [news]: BMJ. 1998 Feb 28;316(7132):645. Unique Identifier : AIDSLINE MED/98183320; Rutter T
Prophylaxis after occupational exposure to HIV. Follow up may have to be for longer than six months [letter]: BMJ. 1998 Feb 28;316(7132):701. Unique Identifier : AIDSLINE MED/98183347; Willcox JR
Prophylaxis after occupational exposure to HIV. Portsmouth has 24 hour hotline staffed by nurse specialists [letter]: BMJ. 1998 Feb 28;316(7132):701. Unique Identifier : AIDSLINE MED/98183346; Harindra V; Tobin J
Prophylaxis after occupational exposure to HIV. Register of cases of occupational exposure exists [letter]: BMJ. 1998 Feb 28;316(7132):701-2. Unique Identifier : AIDSLINE MED/98183348; Evans B; Goldberg D
Prophylaxis after occupational exposure to HIV. "Source testing" should be allowed [letter]: BMJ. 1998 Feb 28;316(7132):702. Unique Identifier : AIDSLINE MED/98183349; Mir N
Prophylaxis after occupational exposure to HIV. Universal precautions should be used during all surgical procedures [letter]: BMJ. 1998 Feb 28;316(7132):702. Unique Identifier : AIDSLINE MED/98183350; Walker PP; Reynolds MT
Survey of French prison found that injecting drug use and tattooing occurred [letter]: BMJ. 1998 Mar 7;316(7133):777. Unique Identifier : AIDSLINE MED/98190222; Rotily M; Delorme C; Obadia Y; Escaffre N; Galinier-Pujol A
EBV-positive primary central nervous system lymphomas in monozygote twins with common variable immunodeficiency and suspected multiple sclerosis.: Leuk Lymphoma. 1997 Dec;28(1-2):187-93. Unique Identifier : AIDSLINE MED/98158484; Jensen MK; Koch-Henriksen N; Johansen P; Varming K; Christiansen CB; Knudsen F; Dept. of Internal Medicine, Aalborg Hospital, Denmark.; Common variable immunodeficiency represents the most frequently occurring primary immunodeficiency disorder and is usually detected sporadically in patients with no family history of immunodeficiency. We present the case stories of two monozygote twins, who following a period of decreasing serum immunoglobulins develo
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults.: Leuk Lymphoma. 1997 Dec;28(1-2):73-82. Unique Identifier : AIDSLINE MED/98158471; Tsuda H; Division of Clinical Hematology and Immunology, Kumamoto City; Hospital, Kumamoto, Japan.; Virus-associated hemophagocytic syndrome (VAHS) is one of the categories of hemophagocytic syndrome (HPS) which is a clinicopathologic entity characterized by systemic proliferation of benign hemophagocytic cells of the monocyte-macrophage-histiocyte lineage, associated with fever, cytopenia, hepatosplenomegaly, lymph
Tuberculosis today--the ongoing challenge [editorial]: Monaldi Arch Chest Dis. 1997 Oct;52(5):417-8. Unique Identifier : AIDSLINE MED/98171646; Avendano MA; Goldstein RS
Antituberculosis drug-resistance surveillance as a tool for tuberculosis control programmes: a retrospective study.: Monaldi Arch Chest Dis. 1997 Oct;52(5):450-4. Unique Identifier : AIDSLINE MED/98171654; La Raja M; Screm C; Talmassons G; Pasquadibisceglie A; Pitzalis G; Pitzus E; Istituto di Microbiologia, Azienda Ospedaliera Santa Maria della; Misericordia, Udine, Italy.; The aim of this study was to verify the suitability of antituberculosis (antiTB) drug-resistance surveillance as a tool for tuberculosis (TB) control programmes at local level. A retrospective study reviewing laboratory records and medical records of TB patients referred to Udine Hospital between 1981 and 1995 was ana
The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe.: Hum Mol Genet. 1998 Mar;7(3):399-406. Unique Identifier : AIDSLINE MED/98133918; Libert F; Cochaux P; Beckman G; Samson M; Aksenova M; Cao A; Czeizel A; Claustres M; de la Rua C; Ferrari M; Ferrec C; Glover G; Grinde B; Guran S; Kucinskas V; Lavinha J; Mercier B; Ogur G; Peltonen L; Rosatelli C; Schwartz M; Spitsyn V; Timar L; Beckman L; Vassart G; et al; IRIBHN and Service de Genetique Medicale, Universite Libre de; Bruxelles, Campus Erasme, B-1070 Brussels, Belgium.; The chemokine receptor CCR5 is encoded by the CMKBR5 gene located on the p21.3 region of human chromosome 3, and constitutes the major co-receptor for the macrophage-tropic strains of HIV-1. A mutant allele of the CCR5 gene, Delta ccr5 , was shown to provide to homozygotes with a strong resistance against infection by
HIV-1 seropositivity and eating disorders: a case report.: Int J Eat Disord. 1998 Jan;23(1):103-6. Unique Identifier : AIDSLINE MED/98091761; Morgan JF; Lacey JH; Department of Mental Health Sciences, St. George's Hospital, London,; United Kingdom.; We report a case of bulimia nervosa in a 21-year-old HIV-positive woman whose seropositivity provoked sustained motivation for recovery from her eating disorder. To the authors knowledge, this is the first report of HIV-1 seropositivity leading to a clinical improvement in an eating disorder. We review the literature
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1997 Apr 25;7(17):153-6. Unique Identifier : AIDSLINE MED/98196320
Effect of HIV counseling and testing on sexually transmitted diseases and condom use in an urban adolescent population.: Arch Pediatr Adolesc Med. 1998 Mar;152(3):269-73. Unique Identifier : AIDSLINE MED/98190262; Clark LR; Brasseux C; Richmond D; Getson P; D'Angelo LJ; Department of Adolescent and Young Adult Medicine, Children's National; Medical Center, Washington, DC, USA.; OBJECTIVE: To determine whether human immunodeficiency virus HIV) counseling and testing has an effect on reducing subsequent risk behaviors in those tested, to evaluate stability in condom use over time, and to determine whether self-reported frequency of condom use relates to the incidence of sexually transmitted di
Generation of primary peptide-specific CD8+ cytotoxic T-lymphocytes in vitro using allogeneic dendritic cells.: Cell Transplant. 1998 Jan-Feb;7(1):1-9. Unique Identifier : AIDSLINE MED/98149402; Peshwa MV; Benike C; Dupuis M; Kundu SK; Engleman EG; Merigan TC; van Schooten WC; Activated Cell Therapy, Inc., Mountain View, CA 94043, USA.; Dendritic cells (DC) are potent antigen-presenting cells (APC) capable of inducing strong T-cell-mediated immunity. Infusion of lymphoma-specific antigen-loaded autologous DC has been demonstrated to result in the generation of antigen-specific immunity and reduction in tumor burden in B-cell lymphoma patients. Cellul
Pneumocystis carinii and the immune response in disease.: Trends Microbiol. 1998 Feb;6(2):71-5. Unique Identifier : AIDSLINE MED/98168485; Hanano R; Kaufmann SH; Dept of Immunology, University of Ulm, Germany.; ralph.hanano@medizin,uni-ulm.de; Pneumocystis carinii causes serious disease in immunocompromised patients, notably in AIDS patients. Our understanding of the biology of this fungus is advancing but still incomplete. Protective immunity against P. carinii is mediated by CD4+ T cells in the immunocompetent host, but precise resistance mechanisms remai
Inhibition of HIV-1 replication by combined expression of gag dominant negative mutant and a human ribonuclease in a tightly controlled HIV-1 inducible vector.: Gene Ther. 1998 Jan;5(1):65-75. Unique Identifier : AIDSLINE MED/98197329; Cara A; Rybak SM; Newton DL; Crowley R; Rottschafer SE; Reitz MS Jr; Gusella GL; Basic Research Laboratory, NCI, NIH, Bethesda, MD, USA.; An HIV-1-based expression vector has been constructed that produces protective genes tightly regulated by HIV-1 Tat and Rev proteins. The vector contains either a single protective gene HIV-1 gag dominant negative mutant (delta-gag)) or a combination of two different protective genes (delta-gag and eosinophil-derived
Transduction of human macrophages using a stable HIV-1/HIV-2-derived gene delivery system.: Gene Ther. 1998 Jan;5(1):99-104. Unique Identifier : AIDSLINE MED/98197333; Corbeau P; Kraus G; Wong-Staal F; Department of Medicine, University of California, San Diego, La Jolla; 92093-0665, USA.; We have previously established a stable HIV-1 packaging cell line, psi 422, which yielded high titers of an HIV-1 vector capable of efficiently transducing CD4+ cells. In order to increase the safety of this gene delivery system, we have now replaced the HIV-1 vector with an HIV-2 vector to abolish any risk of homolog
Cytokines induce the development of functionally heterogeneous T helper cell subsets.: Immunity. 1998 Mar;8(3):275-83. Unique Identifier : AIDSLINE MED/98187994; O'Garra A; DNAX Research Institute, Palo Alto, California 94304-1104, USA.; aog@dnax.org
Coordinate regulation of complex T cell populations responding to bacterial infection.: Immunity. 1998 Mar;8(3):353-62. Unique Identifier : AIDSLINE MED/98188001; Busch DH; Pilip IM; Vijh S; Pamer EG; Section of infectious Diseases, Yale University School of Medicine,; New Haven, Connecticut 06520, USA.; Bacterial infections activate complex T cell populations that differ in size and antigen specificity. We used tetramerized MHC class I molecules complexed with Listeria monocytogenes-derived epitopes to characterize four distinct CD8+ T lymphocyte populations during bacterial infection. Surprisingly, T cell population
Defective NK cell activity and Th1 response in IL-18-deficient mice.: Immunity. 1998 Mar;8(3):383-90. Unique Identifier : AIDSLINE MED/98188004; Takeda K; Tsutsui H; Yoshimoto T; Adachi O; Yoshida N; Kishimoto T; Okamura H; Nakanishi K; Akira S; Department of Biochemistry, Hyogo College of Medicine, Nishinomiya,; Japan.; IL-18 is a cytokine that is secreted from activated macrophages and induces IFNgamma production. To investigate the in vivo role of IL-18, we generated IL-18-deficient mice. In Propionibacterium acnes (P. acnes)-primed IL-18-deficient mice, LPS-induced IFNgamma production was markedly reduced, despite normal IL-12 ind
Retrospective follow-up of maternal deaths and their associated risk factors in a rural district of Tanzania.: Trop Med Int Health. 1998 Feb;3(2):130-7. Unique Identifier : AIDSLINE MED/98196565; MacLeod J; Rhode R; Bagamoyo District Hospital, Tanzania.; OBJECTIVE: To determine the maternal mortality rate in a rural district of Tanzania and to measure the incidence of causes of maternal mortality, the presence of risk factors and the relationship with social and demographic factors. METHOD: From January to December 1993 a retrosp
Xenotransplantation of cells and tissues: application to a range of diseases, from diabetes to Alzheimer's.: Mol Med Today. 1998 Jan;4(1):39-45. Unique Identifier : AIDSLINE MED/98156073; Lanza RP; Cooper DK; Bio Hybrid Technologies, Shrewsburg, MA 01545, USA. rtla@aol.com; The ability to cross species lines will dramatically expand the number of patients and the scope of human diseases that can be treated successfully with transplantation. In addition to whole organs, the transplantation of cells and tissues with specific differentiated functions represents an important conceptual and m
Human melanoma-specific, noncytolytic CD8+ T cells that can synthesize type I cytokine.: Cancer Res. 1998 Apr 1;58(7):1363-6. Unique Identifier : AIDSLINE MED/98196520; Chakraborty NG; Mukherji B; University of Connecticut School of Medicine, Farmington 06030, USA.; The existence of CD8+ CTLs that are capable of recognizing MHC class I-bound, human tumor-associated peptide antigens is now unequivocally documented in cancer patients. Thus far, the role of CD8+ T cells in tumor immunity has been predominantly viewed in terms of cytolytic ability as the prime mode of their function.
HIV seroconversion among factory workers in Harare: who is getting newly infected?: Cent Afr J Med. 1997 May;43(5):135-9. Unique Identifier : AIDSLINE MED/98166352; Mbizvo MT; Latif AS; Machekano R; MacFarland W; Bassett MT; Ray S; Katzenstein D; Zimbabwe AIDS Prevention Project (ZAPP), University of Zimbabwe; Medical School, Avondale, Harare, Zimbabwe.; OBJECTIVE: Zimbabwe , like other countries in sub-Saharan Africa, is experiencing a rapidly growing HIV/AIDS epidemic. It is crucial to determine risk events and socio-demographic characteristics associated with incident infections in order to tailor prevention messages accordingl
All clear for HIV-targeting ribozyme in phase II [news]: Nat Biotechnol. 1998 Feb;16(2):123. Unique Identifier : AIDSLINE MED/98148481; Brower V; Chahine K; Dorey E; Dove A; Francisco M; Hodgson J; Michael A; Marshall A
Self-consistency estimation of distributions based on truncated and doubly censored survival data with applications to AIDS cohort studies.: Lifetime Data Anal. 1997;3(4):305-13. Unique Identifier : AIDSLINE MED/98164629; Sun J; Department of Statistics, University of Missouri, Columbia 65211, USA.; Gomez and Lagakos (1994) propose a nonparametric method for estimating the distribution of a survival time when the origin and end points defining the survival time suffer interval-censoring and right-censoring, respectively. In some situations, the end point also suffers interval-censoring as well as truncation. In t
Mixtures of trifluoroethanol or hexafluoroisopropanol and dimethylformamide are not of general applicability for peptide condensations catalyzed by trypsin.: J Pept Res. 1998 Jan;51(1):29-37. Unique Identifier : AIDSLINE MED/98154976; Bemquerer MP; Liria CW; Kitagawa K; Miranda MT; Tominaga M; Department of Biochemistry, University of Sao Paulo, Brazil.; Mixtures of a good hydrogen bond donor, 2,2,2-trifluoroethanol TFE) or 1,1,1,3,3,3-hexafluroisopropanol, and an acceptor, dimethylformamide (DMF) (1:1, v/v), containing 4% buffer have been described as adequate solvent systems for trypsin-catalyzed peptide fragment condensations [Mihara et al. (1993) Int. J. Pept. Pro
Interruption of T-cell signal transduction by lentivirus lytic peptides from HIV-1 transmembrane protein.: J Pept Res. 1998 Jan;51(1):75-9. Unique Identifier : AIDSLINE MED/98154982; Beary TP; Tencza SB; Mietzner TA; Montelaro RC; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.; Two peptide segments designated LLP1 (residues 828-855) and LLP2 residues 768-788) of the HIV-1 transmembrane (TM) envelope protein display structural and functional properties of calmodulin (CaM) binding. These LLP segments may contribute to cytopathogenesis by binding cellular CaM and inhibiting normal CaM-regulated
Profile of cytokine mRNA expression in peri-implantation human endometrium.: Mol Hum Reprod. 1998 Jan;4(1):77-81. Unique Identifier : AIDSLINE MED/98168834; Lim KJ; Odukoya OA; Ajjan RA; Li TC; Weetman AP; Cooke ID; Sheffield University Department of Obstetrics and Gynaecology, Jessop; Hospital for Women, UK.; The human embryo and subsequent fetus is a semi-allograft and immunologically foreign to the mother. Successful embryonic implantation and maintenance of normal pregnancy depends on intricate interactions between the invading embryo, maternal endometrium and maternal immune response. Cytokines are pivotal in determini
HIV testing and counselling [editorial; comment]: Int J Tuberc Lung Dis. 1997 Dec;1(6):487. Unique Identifier : AIDSLINE MED/98148422; Perriens JH; Kalibala S
Prevalence of the human immunodeficiency virus among patients with tuberculosis in Sierra Leone, established from dried blood spots on filter paper [see comments]: Int J Tuberc Lung Dis. 1997 Dec;1(6):493-7. Unique Identifier : AIDSLINE MED/98148425; Boillot F; Peeters M; Kosia A; Delaporte E; National Leprosy and Tuberculosis Control Programme, Freetown, Sierra; Leone.; SETTING: Sierra Leone National Tuberculosis Programme. OBJECTIVE: To evaluate serological testing in field conditions of dried blood spots (DBS) on filter paper for unlinked surveillance of human immunodeficiency virus (HIV) associated tuberculosis. DESIGN: DBS were first eval
Pleural tuberculosis and human immunodeficiency virus co-infection [see comments]: Int J Tuberc Lung Dis. 1997 Dec;1(6):498-501. Unique Identifier : AIDSLINE MED/98148426; Trajman A; Neto EB; Belo MT; Teixeira EG; Selig L; Ferrari G; Branco MM; Department of Internal Medicine, Gama Filho University, Rio de; Janeiro, Brazil.; SETTING: Department of internal medicine in a general hospital in Rio de Janeiro, Brazil , which provides secondary care to the poor population. OBJECTIVE: The aim of this study was to evaluate the prevalence of human immunodeficiency virus (HIV) infection in patients with pleural t
An incentive in tuberculosis preventive therapy for an inner city population.: Int J Tuberc Lung Dis. 1997 Dec;1(6):576-8. Unique Identifier : AIDSLINE MED/98148438; Mangura BT; Passannante MR; Reichman LB; University of Medicine and Dentistry of New Jersey, Department of; Medicine, Newark, USA.; SETTING: Measures known to improve adherence such as short course chemoprophylaxis and directly observed therapy can be enhanced to a significant extent/by the use of incentives. Adherence to tuberculosis therapy is influenced by several factors, including the health care system, complexity of therapeutic regimens and
Acute hemorrhagic leukoencephalitis during treatment for disseminated tuberculosis in a patient with AIDS.: Int J Tuberc Lung Dis. 1997 Dec;1(6):579-81. Unique Identifier : AIDSLINE MED/98148439; Chetty KG; Kim RC; Mahutte CK; Medical Service, DVA Medical Center, Long Beach, California, USA.; A 45-year-old man with the acquired immune deficiency syndrome AIDS) developed disseminated Mycobacterium tuberculosis infection and was started on isoniazid, rifampin, pyrazinamide and ethambutol. The treatment was interrupted because of side effects. On resumption of treatment be developed a rapidly progressive neur
Tuberculosis significantly reduces the survival of patients with AIDS [letter]: Int J Tuberc Lung Dis. 1997 Dec;1(6):582-4. Unique Identifier : AIDSLINE MED/98148440; Tacconelli E; Tumbarello M; Ardito F; Cauda R
Infection control: HIV/AIDS and other bloodborne pathogens.: Nurs Spectr (Fla). 1998 Jan 12;8(1):12-4. Unique Identifier : AIDSLINE MED/98188987; Casey KM
ANAC conference highlights innovations in HIV/AIDS care.: Nurs Spectr (Gt Chic Ne Ill Nw Indiana). 1998 Jan 12;11(1):12. Unique Identifier : AIDSLINE MED/98188994; Jones SG; Department of Medical/Surgical Nursing, Mount Sinai Medical Center,; Miami Beach, FL, USA.
Infection control: HIV/AIDS and other bloodborne pathogens.: Nurs Spectr (Gt Chic Ne Ill Nw Indiana). 1998 Jan 12;11(1):14-6; quiz 16. Unique Identifier : AIDSLINE MED/98188995; Casey KM; Curry JL; Douglass S
Nasal tolerance in experimental autoimmune myasthenia gravis EAMG): induction of protective tolerance in primed animals.: Clin Exp Immunol. 1998 Mar;111(3):506-12. Unique Identifier : AIDSLINE MED/98187739; Shi FD; Bai XF; Li HL; Huang YM; Van der Meide PH; Link H; Division of Neurology, Karolinska Institute, Huddinge University; Hospital, Stockholm, Sweden.; Nasal administration of microg doses of acetylcholine receptor AChR) is effective in preventing the development of B cell-mediated EAMG in the Lewis rat, a model for human MG. In order to investigate whether nasal administration of AChR modulates ongoing EAMG, Lewis rats were treated nasally with AChR 2 weeks after im
Serum levels of soluble CD30 are increased in ulcerative colitis UC) but not in Crohn's disease (CD).: Clin Exp Immunol. 1998 Mar;111(3):532-5. Unique Identifier : AIDSLINE MED/98187743; Giacomelli R; Passacantando A; Parzanese I; Vernia P; Klidara N; Cucinelli F; Lattanzio R; Santori E; Cipriani P; Caprilli R; Tonietti G; Clinica Medica, University of L'Aquila, Italy.; Imbalance in Th1 and Th2 subsets and their derived cytokines seems to be involved in the immune abnormalities underlying UC and CD. CD30 is a member of the tumour necrosis factor/nerve growth receptor superfamily expressed on T cells producing Th2 cytokines and released as a soluble form. In this study high levels of
The frequency and avidity of committed cytotoxic T lymphocytes cCTL) for donor HLA class I and class II antigens and their relation with graft vascular disease.: Clin Exp Immunol. 1998 Mar;111(3):548-54. Unique Identifier : AIDSLINE MED/98187746; van Besouw NM; Loonen EH; Vaessen LM; Balk AH; Claas FH; Weimar W; Department of Internal Medicine I, University Hospital; Rotterdam-Dijkzigt, Rotterdam, The Nertherlands.; Cellular immune processes may trigger the development of graft vascular disease (GVD). CD4 and CD8 cytotoxic T lymphocytes that infiltrate the allograft could play a role in the development of GVD. We studied the presence of in vivo primed or committed CTL cCTL) and their avidity for donor HLA class I and class II ant
Cytomegalovirus (CMV) infection in AIDS patients is associated with a CD3 receptor-mediated T cell hyporesponsiveness.: Clin Exp Immunol. 1998 Mar;111(3):559-63. Unique Identifier : AIDSLINE MED/98187748; Rowbottom AW; Lepper MW; Sharpstone D; Gazzard B; Department of Pathology and Microbiology, University of Bristol, UK.; HIV+ individuals with human CMV (HCMV) reactivation have a CD3 receptor-mediated T cell hyporesponsiveness when compared with CD4-matched HIV+ and HCMV- control groups. The impairment of proliferation was not reversed by exogenous
The Italian quality control study for evaluation of CD4 cells in centres involved in the treatment of HIV-1 patients. Italian CD4 Quality Control Group.: Clin Exp Immunol. 1998 Mar;111(3):564-73. Unique Identifier : AIDSLINE MED/98187749; Pandolfi F; Alario C; Girardi E; Rava L; Ippolito G; Kunkl A; Aiuti F; Department Clinical Medicine, La Sapienza University, Rome, Italy.; We report on the experience of establishing a national network for a quality control programme in evaluating CD4 cell counts in most Italian centres involved in the care of patients with HIV disease. The 68 centres were divided according to their geographical location into eight groups, and twice a year (tests A and B
HIV/AIDS and children, youths, and families: lessons learned. Introduction.: Child Welfare. 1998 Mar-Apr;77(2):101-5. Unique Identifier : AIDSLINE MED/98175180; Anderson G; Ryan C; Taylor-Brown S; White-Gray M; School of Social Work, Hunter College, New York, NY, USA.
HIV infection and children: a medical overview.: Child Welfare. 1998 Mar-Apr;77(2):107-14. Unique Identifier : AIDSLINE MED/98175181; Anderson V; SUNY Health Science Center, Brooklyn Kings County Medical Center, USA.
Factors associated with parents' decision to disclose their HIV diagnosis to their children.: Child Welfare. 1998 Mar-Apr;77(2):115-35. Unique Identifier : AIDSLINE MED/98175182; Wiener LS; Battles HB; Heilman NE; Pediatric HIV Psychosocial Support Program, National Cancer Institute,; Bethesda, MD, USA.; Parents report that trying to decide whether or not to disclose their HIV diagnosis to their children is as emotionally charged as learning of the diagnosis itself. As part of a larger study, interviews were conducted with 17 parent-child dyads recruited from patients being treated at the National Cancer Institute to
Parental loss due to HIV: caring for children as a community issue--the Rochester, New York experience.: Child Welfare. 1998 Mar-Apr;77(2):137-60. Unique Identifier : AIDSLINE MED/98175183; Taylor-Brown S; Teeter JA; Blackburn E; Oinen L; Wedderburn L; Syracuse University School of Social Work, NY, USA.; The number of children in the United States who will lose a parent to AIDS is increasing. Permanency planning to help families affected by AIDS includes case management, mental health, medical care, child welfare, and legal services. These services are provided by a number of different
Custody planning with HIV-affected families: considerations for child welfare workers.: Child Welfare. 1998 Mar-Apr;77(2):161-77. Unique Identifier : AIDSLINE MED/98175184; Mason S; Department of Psychiatry, University of Illinois at Chicago, USA.; Most of the literature on permanency planning is based on the assumption that HIV-infected parents have custody of their children. A growing number of children entering child protective services, however, have an HIV-infected parent. Whether reunification or adoption is the permanency goal, these parents are concerned
Improving permanency planning in families with HIV disease.: Child Welfare. 1998 Mar-Apr;77(2):180-94. Unique Identifier : AIDSLINE MED/98175185; Draimin BH; Gamble I; Shire A; Hudis J; Family Center, New York, NY, USA.; This article describes two distinct service models developed for providing mental health and custody-planning services to families with advanced HIV disease or AIDS. Project Talk uses cognitive behavior techniques with groups of parents and their teenage children (ages 12 to 18). Project Care employs a psychoeducation
Correlates and distribution of HIV risk behaviors among homeless youths in New York City: implications for prevention and policy.: Child Welfare. 1998 Mar-Apr;77(2):195-207. Unique Identifier : AIDSLINE MED/98175186; Clatts MC; Davis WR; Sotheran JL; Atillasoy A; Institute for AIDS Research, National Development Research Institutes,; Inc., New York, NY, USA.; Homeless youths are at high risk for poor health outcomes, including repeated exposure to STDs and high rates of unplanned pregnancies, untreated TB, HIV infection, and accelerated immune dysfunction associated with AIDS. This article examines the nature and distribution of HIV-risk behavior in a broad, street-based s
HIV prevention for youths in independent living programs: expanding life options.: Child Welfare. 1998 Mar-Apr;77(2):208-21. Unique Identifier : AIDSLINE MED/98175187; Auslander WF; Slonim-Nevo V; Elze D; Sherraden M; George Warren Brown School of Social Work, Washington University, St.; Louis, MO, USA.; The incidence of human immunodeficiency virus (HIV) infection among adolescents is increasing. Youths who were abused and neglected and in out-of-home care are among those at highest risk of acquiring HIV. The concurrence of sexual activity and school failures contributes to their high-risk status. Research suggests t
Shared experiences: three programs serving HIV-positive youths.: Child Welfare. 1998 Mar-Apr;77(2):222-50. Unique Identifier : AIDSLINE MED/98175188; Tenner A; Feudo R; Woods ER; YouthCare, Seattle, WA, USA.; This article presents the major components of three models of linked psychosocial care for HIV-positive youths and youths at high risk for HIV infection: YouthCare (Seattle, Washington), TOPS Program (Bridgeport, Connecticut), and Boston HAPPENS Boston, Massachusetts). These models were developed to connect hard-to-re
A place called HOPE: group psychotherapy for adolescents of parents with HIV/AIDS.: Child Welfare. 1998 Mar-Apr;77(2):251-71. Unique Identifier : AIDSLINE MED/98175189; Gunther M; Crandles S; Williams G; Swain M; State University of New York Health Science Center at Brooklyn, USA.; Project HOPE is a psychosocial support program for noninfected children of HIV-positive parents. The challenges of starting and implementing the program s psychotherapy group for grieving adolescents, and clinical examples of group process and effective interventions in group leadership, are described. Four stages in
Hepatitis, HIV, tuberculosis. Primer on transmission, symptoms, prevention.: Dent Teamwork. 1995 Jan-Feb;8(1):22-5; quiz 26-7. Unique Identifier : AIDSLINE MED/98146623; Maguire K; Department of Applied Dentistry, University of Colorado, USA.
[The treatment of AIDS too expensive? (news)]: Dtsch Med Wochenschr. 1998 Mar 6;123(10):A12. Unique Identifier : AIDSLINE MED/98189123; Kutschki I
The effect of NSAID on T-cell ratios in marginal periodontitis.: Egypt Dent J. 1995 Jan;41(1):1025-30. Unique Identifier : AIDSLINE MED/98159064; el-Sherbiny M; Shoeib MA; Daahab OA; Department of Oral Medicine and Periodontology, Cairo University.; The use of NSAID in the treatment of periodontal disease can augment the conventional periodontal therapy. NSAID can block prostaglandin synthesis which is responsible for the progression of periodontal disease. Inhibition of prostaglandin synthesis reduces the alveolar bone loss, loss of attachment, gingival inflamma
The regulation of primate immunodeficiency virus infectivity by Vif is cell species restricted: a role for Vif in determining virus host range and cross-species transmission.: EMBO J. 1998 Mar 2;17(5):1259-67. Unique Identifier : AIDSLINE MED/98151350; Simon JH; Miller DL; Fouchier RA; Soares MA; Peden KW; Malim MH; Department of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia, PA 19104-6148, USA.; The primate immunodeficiency virus Vif proteins are essential for replication in appropriate cultured cell systems and, presumably, for the establishment of productive infections in vivo. We describe experiments that define patterns of complementation between human and simian immunodeficiency virus (HIV and SIV) Vif p
Characterisation of drug resistant retroviral proteinase mutants.: Biochem Soc Trans. 1997 Nov;25(4):S633. Unique Identifier : AIDSLINE MED/98111714; Good VM; Anderson MM; Baker JJ; Moloudi A; James CH; Wilderspin AF; Department of Pharmaceutical and Biological Chemistry, School of; Pharmacy, London, UK.
A strategy for anti-viral intervention: the use of alpha-glucosidase inhibitors to prevent chaperone-mediated folding of viral envelope glycoproteins.: Biochem Soc Trans. 1997 Nov;25(4):1188-93. Unique Identifier : AIDSLINE MED/98111626; Mehta A; Rudd PM; Block TM; Dwek RA; Department of Biochemistry, Oxford University, U.K.
Modulation of Th1- and Th2-like cytokine production from mitogen-stimulated human peripheral blood mononuclear cells by phosphodiesterase inhibitors.: Gen Pharmacol. 1998 Feb;30(2):175-80. Unique Identifier : AIDSLINE MED/98161274; Yoshimura T; Nagao T; Nakao T; Watanabe S; Usami E; Kobayashi J; Yamazaki F; Tanaka H; Inagaki N; Nagai H; Pharmaceutical Division, Ogaki Municipal Hospital, Gifu, Japan.; 1. Effects of phosphodiesterase (PDE) inhibitors on the production of IFN-gamma, IL-2 , IL-4 and IL-5 by phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC) were investigated. In addition, we investigated the effects of dibutyrylcyclic AM
Condoms. Barriers to bad news.: FDA Consum. 1998 Mar-Apr;32(2):22-5. Unique Identifier : AIDSLINE MED/98194146; Nordenberg T
Ovariectomy does not alter CD4+/CD8+ ratio in peripheral blood T-lymphocytes in the rat.: Horm Metab Res. 1998 Jan;30(1):50-4. Unique Identifier : AIDSLINE MED/98163769; Erben RG; Harti G; Graf H; Institute of Physiology, Physiological Chemistry and Animal Nutrition,; Ludwig Maximilians University, Munich, Germany.; Alterations in peripheral blood T-lymphocyte subsets have been implicated to play a role in the pathophysiology of estrogen deficiency-induced bone loss in postmenopausal women. The aim of this study was to investigate this hypothesis further by flow cytometric analysis of peripheral blood lymphocyte subpopulations to
Th1 cytokine mRNA expression dominates in the skin-draining lymph nodes of C57BL/6 mice following vaccination with irradiated Schistosoma mansoni cercariae, but is down-regulated upon challenge infection.: Immunology. 1998 Jan;93(1):49-54. Unique Identifier : AIDSLINE MED/98197180; Betts CJ; Wilson RA; Department of Biology, University of York, UK.; Vaccination of C57BL/6 mice with irradiated cercariae of Schistosoma mansoni results in the induction of high levels of immunity to subsequent infection. The events occurring in the lymph nodes draining the exposure site have been analysed ex vivo by reverse transcription-polymerase chain reaction (RT-PCR) and the tim
Transmission of genetically diverse strains of HIV-1 in Pune, India.: Indian J Med Res. 1998 Jan;107:1-9. Unique Identifier : AIDSLINE MED/98190679; Gadkari DA; Moore D; Sheppard HW; Kulkarni SS; Mehendale SM; Bollinger RC; National AIDS Research Institute, Pune.; Surveillance of the different HIV-1 subtypes has important implications for developing candidate vaccines and understanding the dynamics of HIV transmission in various populations. In this study, HIV-1 viral subtypes were determined for homologies in the V3-V5 region by heteroduplex mobility assay (HMA) in 46 patients
Repeated treatment with antibody-targeted superantigens strongly inhibits tumor growth.: Int J Cancer. 1998 Apr 13;76(2):274-83. Unique Identifier : AIDSLINE MED/98196941; Rosendahl A; Kristensson K; Hansson J; Ohlsson L; Kalland T; Dohlsten M; Pharmacia and Upjohn, Lund Research Center, Sweden.; alexander.rosendahl@eu.pnu.com; Superantigens (SAg) are microbial proteins with the capacity to activate a large proportion of T cells. We have developed a novel approach for cancer immunotherapy by genetically fusing the SAg staphylococcal enterotoxin A (SEA) to a Fab-fragment of a tumor-specific antibody. Repeated exposure to SEA induces a state o
WHO priorities for a common nursing research agenda.: Int Nurs Rev. 1998 Jan-Feb;45(1):13-4. Unique Identifier : AIDSLINE MED/98152039; Hirschfeld MJ; World Health Organization, Geneva, Switzerland.; In September 1997 a high-powered research team was brought to Geneva by ICN to set priorities and recommend strategies for ICN leadership roles (see INR, November-December 1997, page 161). An analysis of their findings is now being made. Meanwhile, extracts from country and regional reviews of nursing research present
Nursing research in Africa.: Int Nurs Rev. 1998 Jan-Feb;45(1):20. Unique Identifier : AIDSLINE MED/98152041; Tlou SD; Department of Nursing Education, University of Botswana, Gaborone,; Botswana.
[HIV therapy: concepts for today and tomorrow]: Internist (Berl). 1996 Jul;37(7 Suppl Hiv-therap):1-16. Unique Identifier : AIDSLINE MED/98202753
Proton magnetic resonance spectroscopy in brain white matter disorders.: Ital J Neurol Sci. 1997 Dec;18(6):331-9. Unique Identifier : AIDSLINE MED/98155969; De Stefano N; Federico A; Arnold DL; Neurometabolic Unit, University of Siena, Italy.; The advent of magnetic resonance imaging (MRI) has revolutionized the clinical approach to the evaluation of brain white matter disorders and has contributed significantly to expansion of the concept of these diseases. MRI is very sensitive at detecting white matter lesions, but conventional T1 and T2-weighted images
Pulmonary invasive aspergillosis in patients infected with the human immunodeficiency virus: report of two cases.: Heart Lung. 1998 Jan-Feb;27(1):63-6. Unique Identifier : AIDSLINE MED/98152904; Mylonakis E; Mileno MD; Flanigan T; De Orchis DF; Rich J; Department of Medicine, The Miriam Hospital, Brown University School; of Medicine, Providence, RI 02906, USA.; Patients infected with the human immunodeficiency virus (HIV) have an increased frequency of invasive aspergillosis. We report two cases of invasive pulmonary aspergillosis in patients infected with HIV. Patients had less than 10 CD4 (helper cell) cells/mm3 (2/2), presented with fever (2/2), dyspnea (1/2), and abnorma
Gay Men's Health Crisis in New York City advocates physicians reporting HIV-positive patients [editorial]: J Am Osteopath Assoc. 1998 Feb;98(2):77. Unique Identifier : AIDSLINE MED/98170583
A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes.: J Biol Chem. 1998 Mar 20;273(12):6698-703. Unique Identifier : AIDSLINE MED/98175929; Rosin O; Koch C; Schmitt I; Semmes OJ; Jeang KT; Grassmann R; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Schlossgarten 4, D-91054 Erlangen, Federal Republic; of Germany.; The human T-cell leukemia virus type 1 (HTLV-1) transactivator Tax) has been shown to interfere with regulated cellular proliferation. Many studies have focused on the ability of Tax to transform rodent fibroblasts; however, none has defined the molecular requirements for Tax transformation of human lymphoid cells. We
p53 transactivation of the HIV-1 long terminal repeat is blocked by PD 144795, a calcineurin-inhibitor with anti-HIV properties.: J Biol Chem. 1998 Mar 20;273(12):7088-93. Unique Identifier : AIDSLINE MED/98175981; Gualberto A; Marquez G; Carballo M; Youngblood GL; Hunt SW 3rd; Baldwin AS; Sobrino F; Department of Physiology and Biophysics and Ireland Cancer Center,; CWRU School of Medicine, Cleveland, Ohio 44106, USA. axg29@po.cwru.edu; Previous reports have indicated that benzothiophenes exhibit broad anti-inflammatory properties and inhibit human immunodeficiency virus-type 1 (HIV-1) replication. We show that the immunosuppressant cyclosporin A (CsA) and benzothiophene-2-carboxamide, 5-methoxy-3-(1-methyl ethoxy)-1-oxide (PD 144795) block the induc
Antitumour activity of yogurt: study of possible immune mechanisms.: J Dairy Res. 1998 Feb;65(1):129-38. Unique Identifier : AIDSLINE MED/98174244; Perdigon G; Valdez JC; Rachid M; Instituto de Microbiologia, Facultad de Bioquimica, Quimica y; Farmacia, Universidad Nacional de Tucuman, Argentina.; The effect of yogurt on the inhibition of colon tumours induced by 1,2-dimethylhydrazine in BALB/c mice has been studied, and the hypothesis examined that yogurt induces a great reduction in the inflammatory immune response and inhibits tumour growth. Mice were assigned to five experimental groups: a control group fed
Sulfonamide-induced reactions in desensitized patients with AIDS--the role of covalent protein haptenation by sulfamethoxazole.: J Allergy Clin Immunol. 1998 Mar;101(3):371-8. Unique Identifier : AIDSLINE MED/98184366; Gruchalla RS; Pesenko RD; Do TT; Skiest DJ; Department of Medicine, University of Texas Southwestern Medical; Center, Dallas 75235-8859, USA.; BACKGROUND: Adverse reactions to sulfonamides cause significant morbidity in patients with AIDS. We have demonstrated previously a approximately 40 kd sulfamethoxazole (SMX)-substituted protein in the serum of some individuals treated with SMX. OBJECTIVE: The purpose of this study was to examine patients with AIDS who
Cytokine mRNA expression in asthma is not restricted to the large airways.: J Allergy Clin Immunol. 1998 Mar;101(3):386-90. Unique Identifier : AIDSLINE MED/98184368; Minshall EM; Hogg JC; Hamid QA; Meakins-Christie Laboratories, McGill University, Montreal, Quebec,; Canada.; BACKGROUND: Although previous studies have established the presence of an eosinophil-rich cellular infiltrate in the small airways of asthmatic lungs, the expression of cytokines within the peripheral airways has been largely unexplored. The purpose of our study was to test the hypothesis that TH2-type cytokines are i
Molecular features of penicillin allergy.: J Invest Dermatol. 1998 Mar;110(3):203-6. Unique Identifier : AIDSLINE MED/98165258; Weltzien HU; Padovan E; Max Planck Institut fur Immunbiologie, Freiburg, Germany.; Haptens, such as drugs and other low molecular weight chemicals, become immunogenic only upon binding to proteins. Among antibiotics, penicillins are most commonly used for the treatment of bacterial infections and constitute a typical example of allergy inducing drugs in humans. Previous work on their immunologic pro
Interleukin 12 breaks ultraviolet light induced immunosuppression by affecting CD8+ rather than CD4+ T cells.: J Invest Dermatol. 1998 Mar;110(3):272-6. Unique Identifier : AIDSLINE MED/98165271; Schwarz A; Grabbe S; Mahnke K; Riemann H; Luger TA; Wysocka M; Trinchieri G; Schwarz T; Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the; Skin, Department of Dermatology, University Munster, Germany.; Recent studies showed that injection of interleukin (IL)-12 prevents ultraviolet (UV) light mediated suppression of contact hypersensitivity and breaks UV-induced hapten specific tolerance. UV-mediated suppression can be adoptively transferred by injecting splenocytes from UV-irradiated mice; however, suppression is n
Primary non-Hodgkin's lymphoma of the larynx in an AIDS patient.: J Laryngol Otol. 1998 Jan;112(1):77-80. Unique Identifier : AIDSLINE MED/98199254; Simo R; Hartley C; Malik T; Wilson GE; Taylor PH; Mandal BK; Department of Otorhinolaryngology and Head and Neck Surgery, North; Manchester General Hospital, UK.; A case of primary non-Hodgkin s lymphoma of the larynx in an AIDS patient is presented with a review of the literature. Non-Hodgkin s lymphomas in AIDS patients are common but the primary laryngeal presentation is very rare. The symptoms usually include dysphonia and progressive ai
Necrotizing external otitis caused by Aspergillus fumigatus: computed tomography and high resolution magnetic resonance imaging in an AIDS patient.: J Laryngol Otol. 1998 Jan;112(1):98-102. Unique Identifier : AIDSLINE MED/98199260; Munoz A; Martinez-Chamorro E; Departamento de Radiodiagnostico, Hospital Universitario 12 de; Octubre, Madrid, Spain.; Most necrotizing (malignant) external otitis (NEO) occurs in diabetic patients and is commonly caused by Pseudomonas aeruginosa. We report an acquired immunodeficiency syndrome AIDS) patient with NEO caused by Aspergillus fumigatus in which computed tomography (CT) showed destructive petrous bone involvement and magne
Continuing Medical Education (CME) requirements for relicensure of physicians in Florida.: J Fla Med Assoc. 1997 Dec-1998 Jan;84(9):600-1. Unique Identifier : AIDSLINE MED/98166386
Peripheral neuropathies among patients with HIV infection [letter]: J Neurol Neurosurg Psychiatry. 1998 Mar;64(3):414-5. Unique Identifier : AIDSLINE MED/98186402; Alliegro MB; Petrucci A; Arpino C; Dorrucci M; Pezzotti P; Rezza G; Buccoliero G; Tarantini G; Sinicco A; Canessa A
Human immunodeficiency virus activity in rib allografts.: J Oral Maxillofac Surg. 1998 Apr;56(4):474-6. Unique Identifier : AIDSLINE MED/98200419; Marthy S; Richter M; Department of Surgery, University Canton Hospital of Geneva,; Switzerland.; PURPOSE: The use of bone allografts involves the risk of transmitting infectious agents from the donor to the recipient as shown by historical surveys. A study was therefore undertaken to test the hypothesis that human immunodeficiency virus (HIV) activity can still be present after the freezing and thawing of ribs ta
The biology and ethics of banking fetal liver hematopoietic stem cells for in utero transplantation.: J Pediatr Surg. 1998 Feb;33(2):394-9. Unique Identifier : AIDSLINE MED/98158190; Mychaliska GB; Muench MO; Rice HE; Leavitt AD; Cruz J; Harrison MR; Department of Surgery, The Fetal Treatment Center, University of; California, San Francisco 94143-0570, USA.; BACKGROUND/PURPOSE: Transplantation of fetal liver hematopoietic stem cells (HSCs) in utero has the potential to treat a variety of hematologic, immunologic, and metabolic diseases. One prerequisite for broad clinical application is the establishment of a bank of fetal liver HSC tissue. The authors describe their meth
Comparative binding energy analysis of HIV-1 protease inhibitors: incorporation of solvent effects and validation as a powerful tool in receptor-based drug design.: J Med Chem. 1998 Mar 12;41(6):836-52. Unique Identifier : AIDSLINE MED/98187307; Perez C; Pastor M; Ortiz AR; Gago F; Departamento de Farmacologia, Universidad de Alcala, Madrid, Spain.; A comparative binding energy (COMBINE) analysis (Ortiz et al. J. Med. Chem. 1995, 38, 2681-2691) has been performed on a training set of 33 HIV-1 protease inhibitors , and the resulting regression models have been validated using an additional external set of 16 inhi
Tuberculosis in African Americans: clinical characteristics and outcome.: J Natl Med Assoc. 1998 Feb;90(2):73-6. Unique Identifier : AIDSLINE MED/98171609; Funnye AS; Ganesan K; Yoshikawa TT; Division of General Internal Medicine, Charles R. Drew University of; Medicine and Science, Los Angeles, CA 90059, USA.; This study examined the clinical characteristics and outcome of pulmonary tuberculosis in African Americans hospitalized in a teaching hospital in south-central Los Angeles from May 1992 through April 1994. The charts of 41 African Americans with culture-positive Mycobacterium tuberculosis were reviewed. Predisposing
HIV testing, knowledge, attitudes, beliefs, and practices among minorities: pregnant women of North-African origin in southeastern France.: J Natl Med Assoc. 1998 Feb;90(2):87-92. Unique Identifier : AIDSLINE MED/98171611; Messiah A; Rey D; Obadia Y; Rotily M; Moatti JP; South-Eastern French Center for Disease Control, Marseille, France.; Since 1991, the French public health ministry has recommended that human immunodeficiency virus (HIV) testing be offered to all pregnant women. This study was undertaken to determine whether this recommendation is followed independently of a woman s ethnicity. It is based on a 1992 survey regarding knowledge, attitude
A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS Trial. Italy, The Netherlands, Canada and Australia Study [see comments]: JAMA. 1998 Mar 25;279(12):930-7. Unique Identifier : AIDSLINE MED/98204327; Montaner JS; Reiss P; Cooper D; Vella S; Harris M; Conway B; Wainberg MA; Smith D; Robinson P; Hall D; Myers M; Lange JM; Canadian HIV Trials Network, St Paul's Hospital/University of British; Colombia, Vancouver. jmontaner@hivnet.ubc.edu.ca; CONTEXT: Current guidelines recommend that individuals infected with the human immunodeficiency virus type 1 (HIV-1) be treated using combinations of antiretroviral agents to achieve sustained suppression of viral replication as measured by the plasma HIV-1 RNA assay, in the hopes of achieving prolonged remission of t
HIV treatment strategies: planning for the long term [editorial; comment]: JAMA. 1998 Mar 25;279(12):957-9. Unique Identifier : AIDSLINE MED/98204333; Gulick RM
Serosurveillance of HIV infection in people at risk in Hyderabad Sindh.: JPMA J Pak Med Assoc. 1997 Dec;47(12):302-4. Unique Identifier : AIDSLINE MED/98171630; Memon GM; Department of Pathology, Liaquat Medical College, Jamshoro, Sindh.; Random screening of 2000 serum samples of various low and high risk groups was carried out at WHO focal point, Department of Pathology, Liaquat Medical College, Jamshoro, Sindh, during the period between 1994 and 1995. This was done to evaluate the seropositivity. The sample contributors included 600 blood donors, 575
CD4- and TCRalphabeta-positive T lymphocytes predominantly infiltrated into well-moderately differentiated colon adenocarcinoma tissues.: Jpn J Clin Oncol. 1998 Feb;28(2):97-103. Unique Identifier : AIDSLINE MED/98204383; Matsuda S; Yamane T; Hamaji M; Institute of Clinical Research, Kure National Hospital, Hiroshima,; Japan.; Intraepithelial T lymphocytes have been reported as being functional in the growth of epithelial cells and also in the discrimination of aberrant cells, whereas their function against colon adenocarcinoma cells is obscure. The phenotype of colon intraepithelial T lymphocytes has been found in patients with inflammator
The prospective effect of access to medical care on health-related quality-of-life outcomes in patients with symptomatic HIV disease [see comments]: Med Care. 1998 Mar;36(3):295-306. Unique Identifier : AIDSLINE MED/98181572; Cunningham WE; Hays RD; Ettl MK; Dixon WJ; Liu RC; Beck CK; Shapiro MF; Department of Medicine, School of Medicine, University of California,; Los Angeles, USA.; OBJECTIVES: This study examined the prospective effect of reported access to medical care on health-related quality-of-life outcomes in patients with symptomatic human immunodeficiency virus (HIV) disease. METHODS: A cohort study was designed with interviews at baseline, follow-up interviews at 3 months after baseline
HIV disease and women.: Med Clin North Am. 1998 Mar;82(2):335-57. Unique Identifier : AIDSLINE MED/98193080; Klirsfeld D; Bellevue Hospital, New York, New York, USA.; Women with HIV disease are at risk for the same complications as men as their disease progresses. Women, however require some special considerations. This article will elucidate the epidemiology, disease transmission, gynecologic complications, pregnancy, and evaluation of the HIV infected women.
Randomised trial of isoniazid versus rifampicin and pyrazinamide for prevention of tuberculosis in HIV-1 infection.: Lancet. 1998 Mar 14;351(9105):786-92. Unique Identifier : AIDSLINE MED/98178772; Halsey NA; Coberly JS; Desormeaux J; Losikoff P; Atkinson J; Moulton LH; Contave M; Johnson M; Davis H; Geiter L; Johnson E; Huebner R; Boulos R; Chaisson RE; Department of International Health, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Maryland 21205, USA.; BACKGROUND: Tuberculosis is a common complication of HIV-1 infection, especially in developing countries. Practical and effective chemoprophylaxis regimens for HIV-1-related tuberculosis are needed. Our aim was to test the efficacy of isoniazid versus rifampicin with pyrazinamide for prevention of tuberculosis in HIV-
Debate grows on safety of gene-therapy vectors [news]: Lancet. 1998 Mar 14;351(9105):808. Unique Identifier : AIDSLINE MED/98178786; Putman L
Needle-exchange programmes in the USA [letter]: Lancet. 1998 Mar 14;351(9105):839. Unique Identifier : AIDSLINE MED/98178816; Bennett SS
Needle-exchange programmes in the USA [letter]: Lancet. 1998 Mar 14;351(9105):839. Unique Identifier : AIDSLINE MED/98178817; Ward KA; Newlands M; Bullock DW
Abnormal fat accumulation in patients with HIV-1 infection [comment]: Lancet. 1998 Mar 21;351(9106):847-8. Unique Identifier : AIDSLINE MED/98184267; Lipsky JJ; Clinical Pharmacology Unit, Mayo Clinic, Rochester, MN 55905, USA.
"Buffalo hump" in men with HIV-1 infection [see comments]: Lancet. 1998 Mar 21;351(9106):867-70. Unique Identifier : AIDSLINE MED/98184276; Lo JC; Mulligan K; Tai VW; Algren H; Schambelan M; Division of Endocrinology, San Francisco General Hospital, CA 94110,; USA. jlo@itsa.ucsf.edu; BACKGROUND: Enlargement of the dorsocervical fat pad ( buffalo hump ) has been reported in numerous HIV-1-infected patients. Some investigators have speculated that this finding is associated with protease-inhibitor treatment. METHODS: Between June, 1995, and October, 1997, we studied eight HIV-1-infected men who had
Visceral abdominal-fat accumulation associated with use of indinavir [see comments]: Lancet. 1998 Mar 21;351(9106):871-5. Unique Identifier : AIDSLINE MED/98184277; Miller KD; Jones E; Yanovski JA; Shankar R; Feuerstein I; Falloon J; Department of Critical Care Medicine, Warren Grant Magnuson Clinical; Center, National Institutes of Health, Bethesda, MD 20892, USA.; kmiller@atlas.niaid.nih.gov; BACKGROUND: After the addition of the protease inhibitor indinavir to combination drug regimens for HIV-1 infection, some patients have experienced an increase in abdominal girth with symptoms of abdominal fullness, distension, or bloating. We aimed t
High adult mortality in Lusaka [letter]: Lancet. 1998 Mar 21;351(9106):883. Unique Identifier : AIDSLINE MED/98184287; Kelly P; Feldman R; Ndubani P; Baboo KS; Timaeus I; Farthing MJ; Wallman S
[Cerebral toxoplasmosis and AIDS in Martinique]: Med Trop (Mars). 1997;57(3):259-61. Unique Identifier : AIDSLINE MED/98174338; Bouree P; Dumazedier D; Magdeleine C; Sobesky G; Departement des Maladies Parasitaires et Tropicales, Hopital Bicetre,; Kremlin-Bicetre, France.; This study was carried out in 60 AIDS patients who presented toxoplasma encephalitis in Martinique (French West Indies). Diagnosis was based on a combination of fever, neurologic signs, and characteristic CT-scan images in patients
[Aseptic purulent meningitis in two patients co-infected by HTLV-1 and Strongyloides stercoralis]: Med Trop (Mars). 1997;57(3):262-4. Unique Identifier : AIDSLINE MED/98174339; Foucan L; Genevier I; Lamaury I; Strobel M; Departement d'Information Medicale et Sante Publique, CHU de; Pointe-a-Pitre, Guadeloupe, Antitles francaises.; Occurrence of anguilluliasis always progresses to hyperinfestation or disseminated anguilluliasis with severe clinical manifestations in carriers of HTLV-1. This prognosis is further illustrated by two new cases of non-septic purulent meningitis observed in two male patients from Guadalope. Ages were 61 and 64 years.
[Prevalence of HIV infection in an internal medical service in Mozambique (letter)]: Med Trop (Mars). 1997;57(3):309. Unique Identifier : AIDSLINE MED/98174350; Lesens O; Aeres F; Perret JL; Louis FJ; Martet G; Laroche R
Fighting HIV with HIV.: Med Hypotheses. 1998 Jan;50(1):39-42. Unique Identifier : AIDSLINE MED/98147504; Secasan IS; Pop DI; Spitalul Judetean Resita, Romania.
Selective compartmental dominance: an explanation for a noninfectious, multifactorial etiology for acquired immune deficiency syndrome (AIDS), and a rationale for ozone therapy and other immune modulating therapies.: Med Hypotheses. 1998 Jan;50(1):67-80. Unique Identifier : AIDSLINE MED/98147509; Shallenberger F; The most widely accepted etiological explanation for acquired immune deficiency syndrome (AIDS) currently invokes an infectious model involving the human immunodeficiency virus (HIV). Because this infectious model has failed to meet any conventional criteria for establishing microbial causation, this theory still reli
Sarcolemmal excitability in myotonic dystrophy: assessment through surface EMG.: Muscle Nerve. 1998 Apr;21(4):543-6. Unique Identifier : AIDSLINE MED/98192477; Chisari C; D'Alessandro C; Manca ML; Rossi B; Department of Neuroscience, University of Pisa, Italy.; A motor point stimulation protocol was carried out on the tibialis anterior of myotonic dystrophy (MyD) patients. The surface myoelectric signal was monitored to record average rectified value (ARV), median frequency of power spectrum (MDF), and conduction velocity (CV) parameters. The ARV curve showed a decreasing tr
Sub-acute cerebellar degeneration with anti-Yo autoantibodies: immunohistochemical analysis of the immune reaction in the central nervous system.: Neuropathol Appl Neurobiol. 1997 Dec;23(6):468-74. Unique Identifier : AIDSLINE MED/98122044; Giometto B; Marchiori GC; Nicolao P; Scaravilli T; Lion A; Bardin PG; Tavolato B; Department of Neurology and Psychiatry (Second Neurological Clinic),; University of Padova, Italy.; We report the pathological findings of a woman with a sub-acute cerebellar syndrome who had undergone surgery 3 years before for endometrial carcinoma. Both serum and cerebrospinal fluid contained high titres of autoantibodies against the cytoplasm of Purkinje cells that recognized a band of 62 kDa on immunoblotting o
Hospitalization rates of tuberculosis in U.S. Navy enlisted personnel: a 15-year perspective.: Mil Med. 1998 Feb;163(2):71-5. Unique Identifier : AIDSLINE MED/98164646; White MR; Naval Health Research Center, Medical Information Systems and; Operations Research Department, San Diego, CA 92186, USA.; The epidemiology of tuberculosis in this country is changing because of a combination of biological and social factors. The recent use of DNA fingerprinting of Mycobacterium tuberculosis using restriction-fragment-length polymorphism analysis has suggested that nearly one-third of new cases of tuberculosis being repor
Comparison between 201Tl-chloride and 99Tc(m)-sestamibi SPET brain imaging for differentiating intracranial lymphoma from non-malignant lesions in AIDS patients.: Nucl Med Commun. 1998 Jan;19(1):47-53. Unique Identifier : AIDSLINE MED/98175267; Naddaf SY; Akisik MF; Aziz M; Omar WS; Hirschfeld A; Masdeu J; Donnenfeld H; Abdel-Dayem HM; Department of Radiology, St Vincent's Hospital and Medical Center of; NY, New York 10011, USA.; The aim of this study was to compare 201Tl-chloride and 99Tc(m)-sestamibi (MIBI) SPET brain imaging for differentiating brain lymphoma from other intracranial lesions in AIDS patients. Both studies were performed on the same day in 17 AIDS patients with intracranial enhancing lesions on either CT or MRI. Eleven patien
Anterior uveitis and hypotony after intravenous cidofovir for the treatment of cytomegalovirus retinitis.: Ophthalmology. 1998 Apr;105(4):651-7. Unique Identifier : AIDSLINE MED/98204197; Akler ME; Johnson DW; Burman WJ; Johnson SC; Department of Ophthalmology, University of Colorado Health Sciences; Center, Denver 80262, USA.; OBJECTIVE: This study aimed to describe the incidence and risk factors for the development of anterior uveitis in patients receiving intravenous cidofovir for the treatment of longstanding cytomegalovirus retinitis. DESIGN: The study design was a retrospective cohort. PARTICIPANTS:
[Seroprevalence of HBV, HCV and HDV hepatitis markers in 500 patients infected with the human immunodeficiency virus]: Pathol Biol (Paris). 1997 Nov;45(9):701-8. Unique Identifier : AIDSLINE MED/98199269; Denis F; Adjide CC; Rogez S; Delpeyroux C; Rogez JP; Weinbreck P; Departement de Bacteriologie-Virologie-Hygiene (Equipe CNRS: EP 0118),; Limoges, France.; The serological status for both hepatitis B, C and D viruses was analyzed for 500 HIV seropositive patients and for 1037 of a control group. The prevalence was 31.4% for anti HCV, 13.8% for HBs Ag and 69.0% for one or more HBV markers in HIV positive patients and respectively 2.5%, 2.7% and 13.1% in control group. The
[Traceability of drugs derived from blood: regulation and pharmaco-economic implications after 24 months of application in Paris CHU]: Pathol Biol (Paris). 1997 Nov;45(9):741-50. Unique Identifier : AIDSLINE MED/98199275; Lesne-Hulin A; Bourget P; Silvie M; Barath V; Singlas E; Service de Pharmacie Clinique, G.H. Necker-Enfants Malades, Paris,; France.; Since January 1, 1995, the supply, stockage, dispensing and traceability of Blood Derivative Medicinal Products (BDMP) are subject to pharmaceutical regulations. A review of 24 months application at Necker-Enfants Malades Hospital is presented and analysed. A distinction is drawn between two categories of BDMP: 1) an
The experience of being a grandmother who is the primary caregiver for her HIV-positive grandchild.: Nurs Res. 1998 Mar-Apr;47(2):107-13. Unique Identifier : AIDSLINE MED/98197256; Caliandro G; Hughes C; Seton Hall University College of Nursing, South Orange, NJ, USA.; BACKGROUND: The number of grandparents assuming care for their grandchildren is increasing, and this affects grandparents both positively and negatively. The current study builds on an earlier study of the effects of social support, stress, and level of illness on caregiving of children with acquired immune deficiency
The effect of a social support boosting intervention on stress, coping, and social support in caregivers of children with HIV/AIDS.: Nurs Res. 1998 Mar-Apr;47(2):79-86. Unique Identifier : AIDSLINE MED/98197253; Hansell PS; Hughes CB; Caliandro G; Russo P; Budin WC; Hartman B; Hernandez OC; Graduate Nursing Department, Seton Hall University, South Orange, NJ,; USA.; BACKGROUND: Caring for the human immunodeficiency virus HIV)-infected child is challenging and affects the entire family system. Studies have shown that social support can mitigate caregiver stress and enhance coping; however, social support may not always result in a positive outcome for the recipient. OBJECTIVES: To
Legislation in the area of HIV infection.: Nurs Times. 1998 Feb 25-Mar 3;94(8):23. Unique Identifier : AIDSLINE MED/98205639; Hodgson I; University of Bradford.
Neurologic manifestations of HIV infection. Using imaging studies and antiviral therapy effectively.: Postgrad Med. 1998 Mar;103(3):147-50, 153-61. Unique Identifier : AIDSLINE MED/98179539; Rachlis AR; Department of Medicine, Sunnybrook Health Science Centre, University; of Toronto Faculty of Medicine, Ontario, Canada. a.rachlis@utoronto.ca; Patients with HIV infection are at risk for neurologic complications that can arise through various means. Nervous system disorders sometimes occur as a direct consequence of the HIV infection itself. Or, as immunodeficiency progresses, patients can become susceptible to numerous opportunistic infections and other con
[Specific features of cellular immunity of pulmonary tuberculosis in patients with diabetes mellitus]: Probl Tuberk. 1997;(6):59-60. Unique Identifier : AIDSLINE MED/98164690; Karachunskii MA; Gergert VIa; Iakovleva OB; The parameters of cellular immunity were studied in 64 patients with pulmonary tuberculous developed in the presence of type 1 diabetes mellitus and compared with those in 36 patients with pulmonary tuberculosis alone. Patients with concomitant abnormalities showed higher depression of cellular immunity appeared as fe
Production of eosinophil chemotactic factor by CD8+ T-cells in Toxocara canis-infected mice.: Parasitol Res. 1998;84(2):136-8. Unique Identifier : AIDSLINE MED/98154255; Owhashi M; Arita H; Niwa A; Faculty of Integrated Arts and Sciences, University of Tokushima,; Japan. ohashi@ias.tokushima-u.ac.jp; Production of eosinophil chemotactic factor by T-lymphocytes ECF-L) was examined in Toxocara canis-infected mice. When spleen cells from T. canis-infected mice were cultured in serum-free RPMI1640, ECF-L production was detectable in an antigen-specific manner. The ECF-L production peaked at day 9 post-infection and th
The role of CD4+ and CD8+ T-cells in host morbidity and innate resistance to angiostrongylus cantonensis in the mouse.: Parasitol Res. 1998;84(2):91-9. Unique Identifier : AIDSLINE MED/98154248; Aoki M; Sugaya H; Ishida K; Yoshimura K; Department of Parasitology, Akita University, School of Medicine,; Japan.; Strain-dependent differences in host morbidity and mortality due to Angiostrongylus cantonensis infection have been established between C57BL/6 and BALB/c mice; C57BL/6 mice show rapid worm killing with low morbidity, whereas BALB/c mice indicate slow worm killing with high morbidity and mortality. To determine the po
Molecular modeling of interleukin-8 receptor beta and analysis of the receptor-ligand interaction.: Protein Eng. 1997 Sep;10(9):1039-45. Unique Identifier : AIDSLINE MED/98124214; Luo Z; Butcher DJ; Huang Z; Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson; University, Philadelphia, PA 19107, USA.; A structural model of interleukin-8 receptor type beta IL-8R-beta) was constructed based on the structure of bacteriorhodopsin. High temperature molecular dynamics simulations were performed to search the possible conformations of loop regions in IL-8R-beta which recognize the ligand. The crystal structure of interleu
A genetic screen for the isolation and characterization of site-specific proteases.: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2828-33. Unique Identifier : AIDSLINE MED/98169456; Sices HJ; Kristie TM; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Building 4-Room; 133, 9000 Rockville Pike, Bethesda, MD 20892, USA.; Site-specific proteolysis is an important regulatory mechanism in basic cellular and viral processes. Using the protease of the HIV as a model, a genetic system has been developed for the isolation and characterization of site-specific proteases. The system utilizes the well defined bacteriophage lambda regulatory cir
Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules.: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3065-70. Unique Identifier : AIDSLINE MED/98169497; Markiewicz MA; Girao C; Opferman JT; Sun J; Hu Q; Agulnik AA; Bishop CE; Thompson CB; Ashton-Rickardt PG; Gwen Knapp Center for Lupus and Immunology Research, The University of; Chicago, Chicago, IL 60637, USA.; How memory T cells are maintained in vivo is poorly understood. To address this problem, a male-specific peptide (H-Y) was identified and used to activate female anti-H-Y T cells in vitro. Anti-H-Y T cells survived in vivo for at least 70 days in the absence of antigen. This persistence was not because of the intrinsi
Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns.: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3071-6. Unique Identifier : AIDSLINE MED/98169498; Peterson JD; Herzenberg LA; Vasquez K; Waltenbaugh C; Department of Microbiology-Immunology, Northwestern University,; Medical School, Chicago, IL 60611-3072, USA.; Current thinking attributes the balance between T helper 1 (Th1) and Th2 cytokine response patterns in immune responses to the nature of the antigen, the genetic composition of the host, and the cytokines involved in the early interaction between T cells and antigen-presenting cells. Here we introduce glutathione, a t
Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis.: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3111-6. Unique Identifier : AIDSLINE MED/98169505; Flamand L; Crowley RW; Lusso P; Colombini-Hatch S; Margolis DM; Gallo RC; Institute of Human Virology, University of Maryland Biotechnology; Institute at Baltimore, 725 West Lombard Street, Baltimore, MD; 21201-1192, USA.; T cell activation through the T cell receptor is necessary to achieve a specific and effective immune response. We report here that stimulation of CD8+ T cells through the T cell receptor complex leads to de novo expression of the CD4 antigen on the cell surface that results in susceptibility of CD8+ T cells to HIV in
Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3117-21. Unique Identifier : AIDSLINE MED/98169506; Conant K; Garzino-Demo A; Nath A; McArthur JC; Halliday W; Power C; Gallo RC; Major EO; Laboratory of Molecular Medicine and Neuroscience, National Institute; of Neurological Disorders and Stroke, Building 36, Room 5W21, National; Institutes of Health, Bethesda, MD 20892, USA. conant@codon.nih.gov; Activated monocytes release a number of substances, including inflammatory cytokines and eicosanoids, that are highly toxic to cells of the central nervous system. Because monocytic infiltration of the central nervous system closely correlates with HIV-1-associated dementia , it has
Patterns of spirituality in persons with advanced HIV disease.: Res Nurs Health. 1998 Apr;21(2):143-53. Unique Identifier : AIDSLINE MED/98195083; Hall BA; University of Texas at Austin, School of Nursing, USA.; This study was conducted to explicate the role of spirituality in dealing with the many struggles of advanced HIV disease. The research question that guided the study was: How is spiritual meaning structured in advanced stages of HIV disease? Published articles have lacked sound conceptions of spirituality that would
[Kaposi's sarcoma with splenic localization. CT pattern in a case]: Radiol Med (Torino). 1997 Dec;94(6):690-1. Unique Identifier : AIDSLINE MED/98185304; Ferrozzi F; Folegnani F; Campani R; Istituto di Scienze Radiologiche, Universita degli Studi, Parma.; fferrozzi@netsis.it
Ethics in dentistry.: R I Dent J. 1993 Summer;26(2):13, 15-7. Unique Identifier : AIDSLINE MED/98156970; George R Jr; Council on Peer Review, Rhode Island Dental Association, USA.
Ethics in action.: RN. 1998 Mar;61(3):21-4. Unique Identifier : AIDSLINE MED/98205670; Haddad A; School of Pharmacy and Allied Health Professions, Creighton University; in Omaha, USA.
Making HIV therapy more manageable [news]: RN. 1998 Mar;61(3):78. Unique Identifier : AIDSLINE MED/98205679
Psychological and spiritual growth in women living with HIV.: Soc Work. 1998 Mar;43(2):144-54. Unique Identifier : AIDSLINE MED/98188838; Dunbar HT; Mueller CW; Medina C; Wolf T; School of Social Work, University of Hawaii, Honolulu 96822, USA.; Women living with HIV and AIDS face tremendous obstacles to wellness, yet many find ways to use their experience of HIV as a vehicle for psychological and spiritual growth. A qualitative study was conducted to better understand this process. Thirty-four women living with various stages of HIV were interviewed. Five co
HIV/AIDS in a Puerto Rican/Dominican community: a collaborative project with a botanical shop.: Soc Work. 1998 Mar;43(2):183-6. Unique Identifier : AIDSLINE MED/98188840; Delgado M; Santiago J; School of Social Work, Boston University, MA 02215, USA.; delgado@bu.edu
[Are physicians allowed to test for HIV without patients' consent?]: Tidsskr Nor Laegeforen. 1998 Mar 10;118(7):1092. Unique Identifier : AIDSLINE MED/98192989; Hjort H; Helse- og sosialombudeti Oslo.
[Danish physicians underestimate blood-borne transmission. A first case of HIV infection in a surgeon transmitted from a patient is documented (editorial)]: Ugeskr Laeger. 1998 Mar 16;160(12):1769. Unique Identifier : AIDSLINE MED/98197693; Raahave D
[Stab and cut lesions among general practitioners in the county of Funen]: Ugeskr Laeger. 1998 Mar 16;160(12):1781-4. Unique Identifier : AIDSLINE MED/98197697; Sondergaard J; Andersen MB; Odense Universitet, Institut for Sygdomsforebyggelse og Helsetjeneste.; In a questionnaire sent out to general practitioners (GP) in the County of Funen they reported a yearly incidence of lesions penetrating the skin of 1.2 per practitioner. Approximately half of these lesions were potentially infectious. Sixty percent of the lesions were due to accidents involving needles. Only 52% of t
[Percutaneous blood exposure among Danish physicians. Mechanisms and prevention]: Ugeskr Laeger. 1998 Mar 16;160(12):1784-8. Unique Identifier : AIDSLINE MED/98197698; Lunding S; Nielsen TL; Nielsen JO; Hvidovre Hospital, infektionsmedicinsk afdeling.; The study describes the mechanisms of percutaneous blood exposure PCE) among Danish doctors and discusses rational strategies for prevention. Data were obtained as part of a nation-wide survey of occupational blood exposure. The most recent percutaneous or mucocutaneous exposure within the previous three months was de
[Picture of the month (chorioretinitis)]: Ugeskr Laeger. 1998 Mar 23;160(13):1962. Unique Identifier : AIDSLINE MED/98201245; Pedersen C
Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime.: Vaccine. 1998 Mar;16(5):439-45. Unique Identifier : AIDSLINE MED/98152198; Hanke T; Blanchard TJ; Schneider J; Hannan CM; Becker M; Gilbert SC; Hill AV; Smith GL; McMichael A; Molecular Immunology Group, University of Oxford, John Radcliffe; Hospital, U.K.; Human immunodeficiency virus (HIV) vaccine candidates were previously constructed as a string of cytotoxic T lymphocyte CTL) epitopes delivered and expressed using DNA and modified virus Ankara (MVA; an attenuated vaccinia virus) vectors. These vaccines were shown to induce interferon (IFN)-gamma-producing and cytolyt
Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV 16 antigens.: Vaccine. 1998 Mar;16(5):485-92. Unique Identifier : AIDSLINE MED/98152203; Di Fabio S; Medaglini D; Rush CM; Corrias F; Panzini GL; Pace M; Verani P; Pozzi G; Titti F; Laboratorio di Virologia, Istituto Superiore di Sanita, Roma, Italy.; Cynomolgus monkeys (Macaca fascicularis) were immunized by intravaginal administration of live recombinant Streptococcus gordonii. The vaccine strains of S. gordonii expressed the V3 domain of the gpl20 of human immunodeficiency virus type 1 HIV-1), and the E7 protein of human papillomavirus type 16 (HPV 16). Multiple
Modulation of immunologic responses to HIV-1MN recombinant gp160 vaccine by dose and schedule of administration. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.: Vaccine. 1998 Mar;16(5):493-506. Unique Identifier : AIDSLINE MED/98152204; Gorse GJ; McElrath MJ; Matthews TJ; Hsieh RH; Belshe RB; Corey L; Frey SE; Kennedy DJ; Walker MC; Eibl MM; Division of Infectious Diseases and Immunology, Saint Louis University; School of Medicine, MO, USA.; The safety and immunogenicity of HIV-1MN recombinant gp160 (MN rgp160) vaccine in healthy, uninfected volunteers was tested in a double-blind study with a factorial design. By random assignment, 20 volunteers received three 200 micrograms doses of MN rgp160 and four volunteers received placebo at days 0, 28, and 168 o
[Syringe exchange continues (news)]: Vardfacket. 1998 Feb 9;22(2):58. Unique Identifier : AIDSLINE MED/98199666; Forslind E
The effects of treatment with chemical agents or infection with feline viruses on protein-binding properties of the feline immunodeficiency virus long terminal repeat.: Virus Res. 1997 Oct;51(2):203-12. Unique Identifier : AIDSLINE MED/98158383; Ikeda Y; Kawaguchi Y; Inoshima Y; Kohmoto M; Shimojima M; Inada G; Sato E; Kai C; Miyazawa T; Mikami T; Department of Veterinary Microbiology, Graduate School of Agricultural; and Life Sciences, The University of Tokyo, Japan.; The effects of treatment with chemical agents or infection with feline viruses on protein-binding properties of the feline immunodeficiency virus (FIV) long terminal repeat (LTR) were examined by gel-mobility-shift assays using oligonucleotides designed to represent putative AP-1 or ATF motif from the FIV LTR. Infecti
Efficient retroviral gene transfer of a Tat-regulated herpes simplex virus thymidine kinase gene for HIV gene therapy.: Virus Res. 1997 Dec;52(2):133-43. Unique Identifier : AIDSLINE MED/98154917; Caruso M; Bank A; Columbia University College of Physicians and Surgeons, Department of; Medicine, New York, NY 10032, USA.; We have previously reported that lymphoid and monocytic CD4+ cells transfected with and expressing a herpes simplex virus thymidine kinase (HSV-TK) gene, under the transcriptional control of the HIV long terminal repeat, are protected from HIV spread in the presence of 10 microM acy
AIDS pathogenesis: the role of accessory gene mutations, leading to formation of long-lived persistently infected cells and/or apoptosis-inducing HIV-1 particles.: Virus Res. 1997 Dec;52(2):145-56. Unique Identifier : AIDSLINE MED/98154918; Ikuta K; Kameoka M; Luftig RB; Section of Serology, Institute of Immunological Science, Hokkaido; University, Sapporo, Japan. ki@imm.hokudai.ac.jp; Human immunodeficiency virus type 1 (HIV-1) infection indirectly induces activation-dependent apoptosis in bystander immune CD4+ T-cells, a hallmark of AIDS pathogenesis. It is well known that this pathogenetic event is significantly correlated with a high virus load. Active viral replication occurs in HIV-1 asymptoma
[HIV infection, the development of the epidemic in the Russian Federation]: Zh Mikrobiol Epidemiol Immunobiol. 1997 Nov-Dec;(6):47-50. Unique Identifier : AIDSLINE MED/98122197; Onishchenko GG; Narkevich MI; Goliusov AT; Ministry of Public Health of Russia, Moscow.
[The role of mononuclear phagocytes in the immunopathogenesis of HIV infection]: Zh Mikrobiol Epidemiol Immunobiol. 1997 Nov-Dec;(6):51-4. Unique Identifier : AIDSLINE MED/98122198; Zmushko EI; Dmitriev VI; Malkov AN; Mikhal'tsov AN; Bolekhan VN; Mikhailov NV; Military Medical Academy, St. Petersburg, Russia.; The functional state of HIV-infected monocytes in 153 persons aged 20-59 years was studied. It was characterized by an increase in the production of monokines (TNF-alpha, IL1 beta) at stages IIB-IIIA, pronounced activation of the synthesis of DNA at stages IIB-IIC of the disease due to mass intracellular production of
Hemorrhagic presentation of untreated primary CNS lymphoma in a patient with AIDS.: AJR Am J Roentgenol. 1998 Apr;170(4):1114-5. Unique Identifier : AIDSLINE MED/98191114; Fukui MB; Livstone BJ; Meltzer CC; Hamilton RL; University of Pittsburgh Medical Center, PA 15213-2582, USA.
Family physicians and the tuberculosis epidemic [editorial]: Am Fam Physician. 1998 Mar 15;57(6):1228-30, 1235. Unique Identifier : AIDSLINE MED/98193056; Higgins R
Diagnostic approach to the confused elderly patient.: Am Fam Physician. 1998 Mar 15;57(6):1358-66. Unique Identifier : AIDSLINE MED/98193068; Espino DV; Jules-Bradley AC; Johnston CL; Mouton CP; Department of Psychiatry and Behavioral Medicine, University of; Illinois College of Medicine at Peoria, USA.; Confusion in the elderly patient is usually a symptom of delirium or dementia , but it may also occur in major depression and psychoses. Until another cause is identified, the confused patient should be assumed to have delirium, which is often reversible with treatment of the underl
How to treat the cytomegalovirus troll [editorial; comment]: Am J Gastroenterol. 1998 Mar;93(3):293-5. Unique Identifier : AIDSLINE MED/98176803; Goodgame RW
Treatment of cytomegalovirus esophagitis in patients with acquired immune deficiency syndrome: a randomized controlled study of foscarnet versus ganciclovir. The Italian Cytomegalovirus Study Group [see comments]: Am J Gastroenterol. 1998 Mar;93(3):317-22. Unique Identifier : AIDSLINE MED/98176808; Parente F; Bianchi Porro G; Department of Gastroenterology, L. Sacco University Hospital, Milan,; Italy.; OBJECTIVE: Although several uncontrolled studies have shown that the response rate to ganciclovir and foscarnet for all forms of cytomegalovirus ( CMV ) infection in immunocompromised patients is almost similar, to date, no con
Pseudomonas aeruginosa cholangitis in a HIV patient [letter]: Am J Gastroenterol. 1998 Mar;93(3):483-4. Unique Identifier : AIDSLINE MED/98176852; von Wichmann MA; Castiella A; Rodriguez-Arrondo F; Iribarren JA; Arrizabalaga J; Lopez P
Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study.: Am J Kidney Dis. 1998 Apr;31(4):607-17. Unique Identifier : AIDSLINE MED/98189661; Block GA; Hulbert-Shearon TE; Levin NW; Port FK; US Renal Data System, Ann Arbor, MI, USA.; Elevated serum phosphorus is a predictable accompaniment of end-stage renal disease (ESRD) in the absence of dietary phosphate restriction or supplemental phosphate binders. The consequences of hyperphosphatemia include the development and progression of secondary hyperparathyroidism and a predisposition to metastatic
Early treatment with ACE inhibition may benefit HIV-associated nephropathy patients.: Am J Kidney Dis. 1998 Apr;31(4):719-20; discussion 720-2. Unique Identifier : AIDSLINE MED/98189679; Klotman PE; Division of Nephrology, Mt Sinai Medical Center, New York, NY 10029,; USA.
The historical question of acquired immunodeficiency syndrome in the 1960s in the Congo River basin area in relation to cryptococcal meningitis.: Am J Trop Med Hyg. 1998 Mar;58(3):273-6. Unique Identifier : AIDSLINE MED/98206478; Molez JF; Laboratoire de Paludologie, Institut Francais de Recherche; Scientifique pour le Developpement en Cooperation (ORSTOM), Dakar,; Senegal.; In Europe before the advent of the acquired immunodeficiency syndrome (AIDS), fatal cases of infection with Cryptococcus neoformans resembling acute meningitis were rarely described and never in young adults. However, rapidly fatal cryptococcal meningitis in young Africans has been known to exist in central Africa for
Drug-resistant tuberculosis in Singapore, 1995 to 1996.: Ann Acad Med Singapore. 1997 Sep;26(5):549-56. Unique Identifier : AIDSLINE MED/98155761; Boudville IC; Wong SY; Snodgrass I; Department of Clinical Epidemiology, Tan Tock Seng Hospital,; Singapore.; Singapore s tuberculosis incidence of 49 to 57 per 100,000 population for 1987 to 1996 presents a picture that is intermediate between developed and developing countries. The proportion of drug-resistant isolates has remained stable at 4.3% to 5.5% from 1992 to 1996 despite rising HIV rates. From 1995 to 1996, of the
Clinical characteristics and natural history of human immunodeficiency virus infected patients seen at a general hospital in Singapore.: Ann Acad Med Singapore. 1997 Sep;26(5):566-74. Unique Identifier : AIDSLINE MED/98155763; Tan BH; Wong GC; Lam MS; Ang BS; Wong SY; Dept of Internal Medicine and Infectious Diseases, Singapore General; Hospital, Singapore.; The number of patients with human immunodeficiency virus (HIV) infection in Singapore has risen over the years. A considerable proportion of them present with acquired immunodeficiency syndrome (AIDS). In this study, we document the clinical characteristics and natural history o
Ophthalmic manifestations in human immunodeficiency virus infection in Singapore.: Ann Acad Med Singapore. 1997 Sep;26(5):575-80. Unique Identifier : AIDSLINE MED/98155764; Lim SA; Heng WJ; Lim TH; Leo YS; Wong SY; Department of Ophthalmology, Tan Tock Seng Hospital, Singapore.; The paper retrospectively reviews the spectrum of ophthalmic manifestations in human immunodeficiency virus (HIV) infection in Singapore between May 1995 and October 1996. One hundred and eighteen patients were examined for ocular abnormalities. Criteria for examination were 1)
A knowledge, attitudes, beliefs and practices (KABP) survey on HIV infection and AIDS among doctors and dental surgeons in Singapore.: Ann Acad Med Singapore. 1997 Sep;26(5):581-7. Unique Identifier : AIDSLINE MED/98155765; Chan R; Khoo L; Goh CL; Lam MS; National Skin Centre, Singapore.; An anonymous postal questionnaire survey studying the knowledge, attitudes, beliefs and practices on human immunodeficiency virus HIV) infection was conducted among all registered medical and dental practitioners in Singapore in 1996. In all, 1523 replies were received, yielding
Emerging disease surveillance in Southeast Asia.: Ann Acad Med Singapore. 1997 Sep;26(5):628-31. Unique Identifier : AIDSLINE MED/98155773; Corwin A; Simanjuntak CH; Ansari A; Emerging Disease Program, US Naval Medical Research Unit No. 2,; Jakarta, Indonesia.; The emergence of infectious disease causing agents/pathogens necessitates a rational surveillance approach leading to early detection and appropriate intervention. Surveillance activities with support from the US Naval Medical Research Unit No. 2 NAMRU-2), targeting susceptible populations/areas in Southeast Asia, hav
Tuberculosis control in Asia and the western Pacific: a role for computer modelling.: Ann Acad Med Singapore. 1997 Sep;26(5):642-6. Unique Identifier : AIDSLINE MED/98155776; Brewer TF; Heymann SJ; Harris JB; Channing Laboratory, Department of Medicine, Brigham and Women's; Hospital, Boston, MA 02115, USA.; Despite the availability of effective treatment, tuberculosis TB) causes more deaths than any other infection. Most of the world s TB cases and deaths occur in Asia and the Western Pacific, and the growing prevalence of multiple drug-resistant TB and the spread of human immunodeficiency virus (HIV) present ever greate
Emerging pathogens for pneumonia in Singapore.: Ann Acad Med Singapore. 1997 Sep;26(5):651-8. Unique Identifier : AIDSLINE MED/98155778; Lim TK; Department of Medicine, National University Hospital, Singapore.; The death rate from pneumonia in Singapore has increased steadily over the past decade. The emerging respiratory pathogens may have contributed to this increased mortality. New challenges have arisen from changes in the characteristics of the host and the susceptibilities of the
Infection due to Penicillium marneffei.: Ann Acad Med Singapore. 1997 Sep;26(5):701-4. Unique Identifier : AIDSLINE MED/98155786; Sirisanthana T; Department of Medicine, Faculty of Medicine, Chiang Mai University,; Thailand.; Penicillium marneffei is endemic in Southeast Asia, the Guangxi province of China , and Hong Kong . Cases of patients infected with P. marneffei have been very rare, but the incidence has increased
Summary of the international consensus symposium on management of HIV, CMV and hepatitis virus infections.: Antiviral Res. 1998 Jan;37(1):1-16. Unique Identifier : AIDSLINE MED/98156782; de Jong MD; Boucher CA; Danner SA; Gazzard B; Griffiths PD; Katlama C; Lange JM; Richman DD; Vella S; Department of Medical Microbiology, Academic Medical Center,; University of Amsterdam, The Netherlands. m.d.deJong@amc.uva.nl
Pregnancy in women with known HIV infection: what do we and don't we know? [editorial; comment]: Arch Intern Med. 1997 Dec 8-22;157(22):2543-4. Unique Identifier : AIDSLINE MED/98189706; Scarpinato L
Incidence and consequences of pregnancy in women with known duration of HIV infection. Italian Seroconversion Study Group [see comments]: Arch Intern Med. 1997 Dec 8-22;157(22):2585-90. Unique Identifier : AIDSLINE MED/98189713; Alliegro MB; Dorrucci M; Phillips AN; Pezzotti P; Boros S; Zaccarelli M; Pristera R; Rezza G; Istituto Superiore di Sanita, Laboratory of Epidemiology and; Biostatistics, Centro Operativo AIDS, Rome, Italy. mallibar@net.iss.it; BACKGROUND: The increasing incidence of human immunodeficiency virus (HIV) infection in women of childbearing age led us to evaluate whether pregnancy affects the natural history of this disease. OBJECTIVES: To conduct a prospective study of women with known dates of HIV seroconversion to describe the incidence and ou
Lack of response of thrombocytopenia associated with human immunodeficiency virus to triple antiretroviral therapy [letter]: Arch Intern Med. 1997 Dec 8-22;157(22):2669-70. Unique Identifier : AIDSLINE MED/98189730; Domingo P; Coma E; Muniz-Diaz E
[Cardiac changes in children with AIDS]: Arq Bras Cardiol. 1997 Apr;68(4):273-7. Unique Identifier : AIDSLINE MED/98158937; Haddad Herdy GV; Leite MM; Lopes VG; Pinto CA; Barbosa J; Tavares Junior PA; Herdy AH; Almeida PS; de Carvalho R; Barros PB; Neto MB; Ramos RG; Hospital Universitario Antonio Pedro, UFF, Niteroi.; PURPOSE: To describe the cardiac findings in children with AIDS, the follow-up with treatment and the correlation between clinical and pathological features. METHODS: We studied prospectively 25 children with clinical-laboratorial diagnosis of AIDS, ages between 3 months and 11 years, even those without cardiac sympto
Depressive symptoms in patients with HIV infection: a further exploration.: Aust N Z J Psychiatry. 1997 Dec;31(6):862-8. Unique Identifier : AIDSLINE MED/98144254; Judd F; Mijch A; McCausland J; Cockram A; University of Melbourne, Department of Psychiatry, Royal Melbourne; Hospital, Parkville, Victoria, Australia.; OBJECTIVE: The aim of this study was to assess the frequency and severity of depressive symptoms, to determine the rate of depressive disorder, to explore possible reasons for the development of depressive symptoms and to examine the effects of depression in a group of human immunodeficiency virus HIV)-positive patien
Ubiquitin-like polypeptide conjugates to acceptor proteins in concanavalin A- and interferon gamma-stimulated T-cells.: Biochem J. 1998 Mar 1;330 ( Pt 2):683-8. Unique Identifier : AIDSLINE MED/98149737; Nakamura M; Tanigawa Y; Department of Biochemistry, Shimane Medical University, 89-1 Enya-cho,; Izumo 693, Japan.; Monoclonal non-specific suppressor factor (MNSF), a lymphokine produced by a murine T-cell hybridoma, possesses pleiotrophic non-specific suppressive functions. MNSFbeta (a subunit of MNSF) is a 14.5 kDa fusion protein consisting of a protein with 36% homology with ubiquitin and ribosomal protein S30. The ubiquitin-li
Clonally expanded Valpha12+ (AV12S1),CD8+ T cells from a patient with rheumatoid arthritis are autoreactive.: Arthritis Rheum. 1998 Mar;41(3):498-506. Unique Identifier : AIDSLINE MED/98165422; Behar SM; Roy C; Lederer J; Fraser P; Brenner MB; Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.; OBJECTIVE: Previously, we showed that 15-20% of patients with rheumatoid arthritis (RA) have oligoclonal expansions of peripheral blood CD8+ T cells expressing T cell receptors encoded by the V(alpha)12 (AV12S1) gene. To better understand the significance of these expansions, the present study was undertaken to determ
[Pneumocystis carinii otitis]: Laryngorhinootologie. 1997 Dec;76(12):745-8. Unique Identifier : AIDSLINE MED/98148468; Biermann E; HNO-Abteilung des Allgemeinen Krankenhauses St. Georg, Hamburg.; BACKGROUND: Pneumocystis carinii (PC) otitis is a rare opportunistic infection of the acquired immunodeficiency syndrome AIDS). Initially hearing loss and otalgia occur with thickening of the tympanic membrane and the bordering skin of the ear canal. Otorrhea, ear polyps, perforation of tympanic membrane, destruction
Glycosidopyrroles. Part 1. Acyclic derivatives: 1-(2-hydroxyethoxy)methylpyrroles as potential anti-viral agents.: Farmaco. 1998 Jan;53(1):33-40. Unique Identifier : AIDSLINE MED/98205306; Almerico AM; Diana P; Barraja P; Dattolo G; Mingoia F; Loi AG; Scintu F; Milia C; Puddu I; La Colla P; Istituto Farmacochimico, Universita degli Studi, Palermo, Italy.; Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both strains HSV-1 and HSV-2 at concentrations s
Veto cell suppression mechanisms in the prevention of allograft rejection.: APMIS. 1998 Mar;106(3):345-53. Unique Identifier : AIDSLINE MED/98208201; Jacobsen IM; Claesson MH; Department of Medical Anatomy, Panum Institute, University of; Copenhagen, Denmark.; Substantial evidence has accumulated to suggest that in the near future implementation of the veto-cell-suppressor concept in the treatment of kidney allograft recipients might lead to the establishment of life-long specific allograft tolerance in the absence of further immunosuppressive therapy. Veto suppression prev
[Microglia: function in the pathological state]: No To Shinkei. 1998 Jan;50(1):5-16. Unique Identifier : AIDSLINE MED/98154235; Nakajima K; Kohsaka S; Department of Neurochemistry, National Institute of Neuroscience,; Tokyo, Japan.
Prurigo as a clinical prodrome to adult T-cell leukaemia/lymphoma.: Br J Dermatol. 1998 Jan;138(1):137-40. Unique Identifier : AIDSLINE MED/98197299; Setoyama M; Mizoguchi S; Kanzaki T; Department of Dermatology, Kagoshima University Faculty of Medicine,; Japan.; We report a case of adult T-cell leukaemia/lymphoma (ATLL) with prurigo as a prodromal skin manifestation. The patient was a 52-year-old woman with a 2-year history of a fluctuating skin condition consisting of pruritic papules and pigmentation on her lower legs and right buttock. Prurigo was diagnosed at her first vi
Crusted scabies with scalp involvement in HIV-1 infection [letter]: Br J Dermatol. 1998 Jan;138(1):192-3. Unique Identifier : AIDSLINE MED/98197312; Farrell AM; Ross JS; Bunker CB; Staughton RC
Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.: Biochemistry. 1998 Mar 31;37(13):4510-7. Unique Identifier : AIDSLINE MED/98190026; Moulard M; Challoin L; Canarelli S; Mabrouk K; Darbon H; C.I.M.L., Marseille, France, Laboratoire AFMB, IBSM, Marseille,; France. moulard@ciml.univ-mrs.fr; Proteolytic activation of retroviral envelope glycoprotein precursors occurs at the carboxyl side of a consensus motif consisting of the amino acid sequence Arg/Lys)-Xaa-(Arg/Lys)-Arg. Synthetic peptides spanning the processing sites of HIV-1/2 and SIV glycoprotein precursors were examined for their ability to be clea
Structural basis for specificity of retroviral proteases.: Biochemistry. 1998 Mar 31;37(13):4518-26. Unique Identifier : AIDSLINE MED/98190027; Wu J; Adomat JM; Ridky TW; Louis JM; Leis J; Harrison RW; Weber IT; Department of Microbiology and Immunology, Kimmel Cancer Center,; Thomas Jefferson University, Philadelphia, Pennsylvania 19107,; The Rous sarcoma virus (RSV) protease S9 variant has been engineered to exhibit high affinity for HIV-1 protease substrates and inhibitors in order to verify the residues deduced to be critical for the specificity differences. The variant has 9 substitutions (S38T, I42D, I44V, M73V, A100L, V104T, R105P, G106V, and S10
Epitope mapping and serodiagnosis using Ata- and (Lys)7 peptides.: Biochim Biophys Acta. 1998 Feb 2;1379(2):273-81. Unique Identifier : AIDSLINE MED/98189241; Loomans EE; Nijholt LJ; Cremers AJ; Paulij WP; Schielen WJ; Chemistry Research Unit, Organon Teknika B.V., Akzo Nobel, Boxtel, The; Netherlands.; The general applicability of the new peptide immobilization strategy in which the peptide of interest is N-terminally extended with an acetyl-thio-acetyl group or (poly)-Lys extension during synthesis, has been demonstrated in epitope-mapping experiments and serodiagnosis. Ala-scanning experiments and minimal epitope
Inhibition of human immunodeficiency virus type 1 replication in myelomonocytic cells derived from retroviral vector-transduced peripheral blood progenitor cells.: Hum Gene Ther. 1998 Feb 10;9(3):333-40. Unique Identifier : AIDSLINE MED/98167470; Junker U; Kalfoglou CS; Moon JJ; Beck MK; Kaneshima H; Bohnlein E; Systemix, Inc., Palo Alto, CA 94304, USA.; Monocytes and macrophages (Mo/Mphi) contribute to the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection. A successful hematopoietic stem/progenitor cell HSPC)-based gene therapy strategy for HIV-1 disease must protect Mo/Mphi as well as T cells from HIV-1-related pathology. In this report, we demon
Bone marrow stromal cells as targets for gene therapy of hemophilia A.: Hum Gene Ther. 1998 Feb 10;9(3):353-65. Unique Identifier : AIDSLINE MED/98167472; Chuah MK; Brems H; Vanslembrouck V; Collen D; Vandendriessche T; Center for Transgene Technology and Gene Therapy, Flanders; Interuniversity Institute for Biotechnology-University of Leuven,; Belgium.; Attempts to develop an ex vivo gene therapy strategy for hemophilia A, using either primary T cells or bone marrow (BM) stem/progenitor cells have been unsuccessful, due to the inability of these cell types to express coagulation factor VIII FVIII). As an alternative, we evaluated the potential of BM-derived stromal c
Prevalence of HSV-2 antibodies among STD clinic patients in Tanzania.: Int J STD AIDS. 1998 Feb;9(2):104-7. Unique Identifier : AIDSLINE MED/98165199; Langeland N; Haarr L; Mhalu F; Department of Internal Medicine, Haukeland Hospital and University of; Bergen, Norway.; Patients attending a referral sexually transmissible diseases clinic at Muhimbili Medical Centre in Dar-es-Salaam during the period 1989 to 1993 were examined for herpes simplex virus type 2 HSV-2) antibodies. An ELISA technique, using glycoprotein G of HSV-2 as antigen, was used to test 294 patients sera. Of these,
Hypothyroidism and hypoparathyroidism associated with Pneumocystis carinii infection in a patient with AIDS.: Int J STD AIDS. 1998 Feb;9(2):108-10. Unique Identifier : AIDSLINE MED/98165200; Siddiqi A; Goh BT; Brown CL; Hillman RJ; Monson JP; Department of Endocrinology, St Bartholomew's & Royal London School of; Medicine and Dentistry, UK.
Granulomatous extrapulmonary pneumocystosis.: Int J STD AIDS. 1998 Feb;9(2):111-3. Unique Identifier : AIDSLINE MED/98165201; Tan GD; Shaw PJ; Miller RF; Department of Sexually Transmitted Diseases, University College London; Hospitals NHS Trust, UK.
Malignant syphilis: an immunological puzzle.: Int J STD AIDS. 1998 Feb;9(2):114-6. Unique Identifier : AIDSLINE MED/98165202; Kumar B; Muralidhar S; Das A; Department of Dermatology, Postgraduate Institute of Medical Education; and Research, Chandigarh, India.
The management of Chlamydia trachomatis genital infection in genitourinary medicine clinics in the Wessex region.: Int J STD AIDS. 1998 Feb;9(2):117-20. Unique Identifier : AIDSLINE MED/98165203; Priestley CJ; Department of Genitourinary Medicine, Weymouth Community Hospital,; Dorset, UK.; The management of cases of Chlamydia trachomatis genital infection diagnosed in clinics in Wessex in the last quarter of 1996 was surveyed, and the results compared with those obtained in the national gonorrhoea audit. Treatment regimens were extremely varied both between and within clinics. Overall, 71% of patients s
The presence of cotton-wool spots is predictive for the development of CMV retinitis [letter]: Int J STD AIDS. 1998 Feb;9(2):122-3. Unique Identifier : AIDSLINE MED/98165204; Morlat P; Chene G; Vimard E; Dumas B; Ragnaud JM; Beylot J
The role of Ureaplasma urealyticum [letter]: Int J STD AIDS. 1998 Feb;9(2):123-4. Unique Identifier : AIDSLINE MED/98165205; Taylor-Robinson D
A spotted fever and melaena: acute HIV seroconversion [letter]: Int J STD AIDS. 1998 Feb;9(2):124. Unique Identifier : AIDSLINE MED/98165207; Brook MG
Schistosomiasis is another important cause of microscopic haematuria [letter]: Int J STD AIDS. 1998 Feb;9(2):124. Unique Identifier : AIDSLINE MED/98165206; Fox EF; Smith NA; Dean GL; Bingham JS
Infectious hepatitis in HIV-seropositive patients.: Int J STD AIDS. 1998 Feb;9(2):63-9. Unique Identifier : AIDSLINE MED/98165192; Newell A; Nelson M; Department of HIV/GUM, Kobler Centre, St Stephen's Clinic, Chelsea and; Westminster Hospital, London, UK.
Professional competence of doctors in the United Kingdom.: Int J STD AIDS. 1998 Feb;9(2):70-3. Unique Identifier : AIDSLINE MED/98165193; Talbot M; Department of Genito-Urinary Medicine, Royal Hallamshire Hospital,; Sheffield, UK.
The vulval pain syndromes.: Int J STD AIDS. 1998 Feb;9(2):74-8; quiz 79. Unique Identifier : AIDSLINE MED/98165194; Edwards A; Wojnarowska F; Genitourinary Medicine Department, The Radcliffe Infirmary NHS Trust,; Oxford, UK.
Combination therapy for HIV: the effect on inpatient activity, morbidity and mortality of a cohort of patients.: Int J STD AIDS. 1998 Feb;9(2):80-7. Unique Identifier : AIDSLINE MED/98165195; Brettle RP; Wilson A; Povey S; Morris S; Morgan R; Leen CL; Hutchinson S; Lewis S; Gore S; Regional Infectious Disease Unit, City Hospital, Edinburgh, UK.; We set out to quantify the changes in HIV-related morbidity and mortality associated with the clinical use of antiretroviral therapy via prospectively collected patient-related events admissions, bed days, deaths, WHO stage 3 and 4 events and drug costs) on all HIV patients known to the Regional Infectious Disease Uni
Prevalence, causes and outcome of vulval pain in a genitourinary medicine clinic population.: Int J STD AIDS. 1998 Feb;9(2):88-91. Unique Identifier : AIDSLINE MED/98165196; Denbow ML; Byrne MA; Department of Genitourinary Medicine, St Mary's Hospital, London, UK.; A detailed assessment was completed on 150 consecutive new female patients attending a walk-in genitourinary medicine clinic, in order to elicit the features of vulval pain. Twenty patients 13.3%) experienced vulval pain, and of these, 15 (75%) had an infective cause demonstrated. Candidiasis was demonstrated in more
The effect of nonoxynol-9 and chlorhexidine on HIV and sperm in vitro.: Int J STD AIDS. 1998 Feb;9(2):92-7. Unique Identifier : AIDSLINE MED/98165197; Harrison C; Chantler E; Department of Obstetrics and Gynaecology and Reproductive Healthcare,; University of Manchester, UK.; The effect of chlorhexidine and nonoxynol-9, either singly or in combination, on the replication and infectivity of HIV and the survival of both lymphocytes (MT2 cells) and human spermatozoa, was studied in vitro. Exposure of MT2 cells to 200 microg/ml nonoxynol-9 or 1 mg/ml chlorhexidine for one minute destroyed thei
Prevalence and risk factors of HIV-1 and HIV-2 infection in urban and rural areas in Tamil Nadu, India.: Int J STD AIDS. 1998 Feb;9(2):98-103. Unique Identifier : AIDSLINE MED/98165198; Solomon S; Kumarasamy N; Ganesh AK; Amalraj RE; YRG Centre for AIDS Research and Education, Madras, India.; We aim to study the factors associated with the prevalence of HIV-1 and HIV-2 infection in the urban and rural areas of Tamil Nadu, India . The population of Tamil Nadu is approximately 60 million. Between April 94 and March 95, 992 samples from 5 representative urban centres and 107
Insulin therapy of prediabetes suppresses TH1 associated gene expression in BB rat pancreas.: Autoimmunity. 1997;26(1):1-6. Unique Identifier : AIDSLINE MED/98140608; Kolb H; Worz-Pagenstert U; Kleemann R; Rothe H; Rowsell P; Rastegar S; Scott FW; Diabetes Research Institute at the University of Dusseldorf, Germany.; kolb@dfi.uni-duesseldorf.de; Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implante
Multiple eruptive dermatofibromas in three men with HIV infection.: Dermatology. 1997;195(4):344-8. Unique Identifier : AIDSLINE MED/98190372; Ammirati CT; Mann C; Hornstra IK; Department of Medicine, Washington University School of Medicine, St.; Louis, MO 63110, USA.; BACKGROUND: Multiple eruptive dermatofibromas (MEDF) are rare and their etiology is unknown. An association with immunosuppression has led to the speculation that they are the result of an abortive immunoreactive process. In the literature, there have been 5 isolated case reports of multiple dermatofibromas and human
Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation.: Dermatology. 1997;195(4):353-8. Unique Identifier : AIDSLINE MED/98190374; Smith KJ; Skelton HG; Yeager J; Lee RB; Wagner KF; Department of Dermatology, National Naval Medical Center, Bethesda, MD; 20889-5600, USA.; BACKGROUND: Pruritus in HIV-1+ patients is common and increases with disease progression. The causes of pruritus are numerous including xerosis, drug and photoeruptions, follicular and papular eruptions as well as infestations and infections by a wide range of organisms. One other possible factor contributing to pruri
Topical immune modulation with dinitrochlorobenzene in HIV disease: a controlled trial from Brazil.: Dermatology. 1997;195(4):369-73. Unique Identifier : AIDSLINE MED/98190377; Traub A; Margulis SB; Stricker RB; Sexually Transmitted Disease Unit, Irmandade da Santa Casa de; Misericordia, Porto Alegre, Brazil.; OBJECTIVE: Despite the rapid spread of human immunodeficiency virus (HIV) in the developing countries of Africa, Asia and Latin America, accessible and affordable antiretroviral therapies have not been developed. Dinitrochlorobenzene (DNCB) is an inexpensive contact sensitizing agent that stimulates cell-mediated immu
Dideoxyinosine-associated Ofuji papuloerythroderma in an HIV-infected patient [letter]: Dermatology. 1997;195(4):410-1. Unique Identifier : AIDSLINE MED/98190390; Just M; Carrascosa JM; Ribera M; Bielsa I; Ferrandiz C
Chemotherapy in HIV-infected patients with Kaposi's sarcoma [letter]: Dermatology. 1997;195(4):411-2. Unique Identifier : AIDSLINE MED/98190391; Pechere M; Krischer J; Rutschmann OT
Body composition changes in patients with human immunodeficiency virus infection.: Nutrition. 1997 Jul-Aug;13(7-8):629-32. Unique Identifier : AIDSLINE MED/97408735; Bell SJ; Bistrian BR; Connolly CA; Forse RA; Harvard Medical School, Boston, Massachusetts, USA.; Malnutrition characterized by weight loss and often extreme wasting generally develops when patients progress from infection with human immunodeficiency virus (HIV) to AIDS. There is evidence that before the development of AIDS, HIV-infected patients without weight loss show early signs of malnutrition, defined as an
Glutamine requirement of proliferating T lymphocytes [see comments]: Nutrition. 1997 Jul-Aug;13(7-8):646-51. Unique Identifier : AIDSLINE MED/97408738; Yaqoob P; Calder PC; Department of Biochemistry, University of Oxford, United Kingdom.; Glutamine is required for lymphocyte proliferation but the site of glutamine action is not yet known. In this study, the effect of glutamine on key events that occur during lymphocyte activation [interleukin-2 ( IL-2 ) production, IL-2 use, IL-2 receptor expression, tran
Host-cell-specific glycosylation of HIV-2 envelope glycoprotein.: Glycoconj J. 1997 Nov;14(7):785-93. Unique Identifier : AIDSLINE MED/98170934; Liedtke S; Geyer R; Geyer H; Institute of Biochemistry, University of Giessen, Germany.; Neutral complex-type N-glycans of the envelope glycoprotein 120 of HIV-2, propagated in different host cells, display cell-type specific variations. In order to identify typical structural elements, glycans were analysed by gel filtration, by enzymic sequencing and, in part, by matrix-assisted laser desorption/ionizat
The Th1/Th2 paradigm and experimental murine leishmaniasis.: Int Arch Allergy Immunol. 1998 Mar;115(3):191-202. Unique Identifier : AIDSLINE MED/98189645; Lohoff M; Gessner A; Bogdan C; Rollinghoff M; Institut fur Klinische Mikrobiologie und Immunologie, Universitat; Erlangen, Deutschland.; In recent years, the Th1/Th2 concept has become of prime importance in the understanding of heterogeneous responses of the immune system and implications thereof for infectious and autoimmune diseases. Originally established on the basis of different cytokines produced by T cell clones, it is now known that the Th1/Th
Receptor-mediated maternofetal transfer of immunoglobulins. Inhibition of transport of anti-HIV-1 immunoglobulin by generic immunoglobulins in the in vitro perfused placenta.: Int Arch Allergy Immunol. 1998 Mar;115(3):203-9. Unique Identifier : AIDSLINE MED/98189646; Landor M; Rubinstein A; Kim A; Calvelli T; Mizrachi Y; Department of Microbiology and Immunology, Albert Einstein College of; Medicine, Bronx, NY 10461, USA.; OBJECTIVES: The passage of immunoglobulin G (IgG) across the placenta is thought to involve Fc receptors on the syncytiotrophoblast. To confirm the receptor dependency of this process we have studied the changes in the tissue content and transfer kinetics of immunoglobulins and hyperimmune serum to HIV HIVIG) during
Alternative G1m, G2m and G3m allotypes of IGHG genes correlate with atopic and nonatopic pathways of immune regulation in children with bronchial asthma.: Int Arch Allergy Immunol. 1998 Mar;115(3):215-9. Unique Identifier : AIDSLINE MED/98189648; Oxelius VA; Carlsson AM; Aurivillius M; Department of Pediatrics and Clinical Immunology, University Hospital,; University of Lund, Sweden.; Most genetic studies of bronchial asthma deal with IgE responsiveness. The manner by which allergens trigger IgE production and activate mast cells suggests that several genetic loci may be involved. Several reports of candidate genes include chromosome 6 and HLA antigens, chromosome 14q11 and the alpha chain of the T
[Common variable immunodeficiency--analysis of the clinical aspects and results of substitution treatment]: Pneumonol Alergol Pol. 1997;65(3-4):187-97. Unique Identifier : AIDSLINE MED/98150672; Kus J; Maziarka D; I Kliniki Gruzlicy, Warszawie.; The clinical picture and the effects of treatment with intravenous immunoglobulins of 14 adult patients (4 women, 10 men) with common variable immunodeficiency are presented. In most patients the disease began in the second decade of life (17.4 years on average), and the diagnosis was delayed by 7.5 years. Mean observ
[Immunomodulatory properties of subtherapeutic levels of theophylline]: Pneumonol Alergol Pol. 1997;65(3-4):288-91. Unique Identifier : AIDSLINE MED/98150687; Chorostowska-Wynimko J; Zakladu Immunologii Instytutu Gruzlicy i Chorob Pluc w Warszawie.
AIDS Czarina [interview by Theresa Hudson]: Hosp Health Netw. 1998 Feb 20;72(4):26. Unique Identifier : AIDSLINE MED/98214127; Thurman S
Combinatorial peptide library as an immunogen.: Methods Mol Biol. 1998;87:281-96. Unique Identifier : AIDSLINE MED/98183879; Estaquier J; Ameisen JC; Auriault C; Boutillon C; Gras-Masse H; Tartar A; La Jolla Institute for Allergy and Immunology, San Diego, CA, USA.
Quantification of the aortic regurgitant volume with magnetic resonance phase velocity mapping: a clinical investigation of the importance of imaging slice location.: J Heart Valve Dis. 1998 Jan;7(1):94-101. Unique Identifier : AIDSLINE MED/98161249; Chatzimavroudis GP; Oshinski JN; Franch RH; Pettigrew RI; Walker PG; Yoganathan AP; Cardiovascular Fluid Mechanics Laboratory, School of Chemical; Engineering, Georgia Institute of Technology, Atlanta 30332-0100, USA.; BACKGROUND AND AIMS OF THE STUDY: Current techniques for assessment of aortic regurgitation (AR) are mainly qualitative. Magnetic resonance phase velocity mapping (PVM) provides accurate measurements of arterial blood blow. In AR, the aortic regurgitant volume (ARV) can be quantified with a single imaging slice measur
[A clinical and biological study of parasitic and fungal diarrhea in immunosuppressed patients in an urban and suburban area of Yaounde]: Sante. 1997 Nov-Dec;7(6):349-54. Unique Identifier : AIDSLINE MED/98164232; Same-Ekobo A; Lohoue J; Mbassi A; Laboratoire de parasitologie, mycologie et immunologie parasitaire,; CHU de Yaounde, Cameroun.; We studied 66 cases of intestinal mycosis and parasitosis in patients infected with the human immunodeficiency virus with chronic diarrhea. All subjects were from the Yaounde urban area and were followed between February and December 1996. They were recruited from 3 hospitals in the center of Yaounde and were aged bet
[The prevalence of HIV and risk behavior of prostitutes living in 2 populous regions of Bujumbura (Burundi)]: Sante. 1997 Nov-Dec;7(6):355-60. Unique Identifier : AIDSLINE MED/98164233; Buzingo T; Alary M; Sokal DC; Saidel T; Faculte de medecine, Departement de medecine sociale et preventive,; Universite Laval, Quebec, Canada.; This study was designed to determine the prevalence of HIV infection and associated high-risk behavior in female sex workers in two areas of Bujumbura (Bwiza and Musanga), Burundi . Between June 15th and July 15th 1993, 320 female sex workers responded to an anonymous questionnaire
[Pediatric AIDS at the University Hospital Center-Tokoin (Lome): the role of protein-calorie malnutrition and a formulation trial of a clinical diagnostic score]: Sante. 1997 Nov-Dec;7(6):397-404. Unique Identifier : AIDSLINE MED/98164239; Atakouma DY; Agbere AR; Tsolenyanu E; Kusiaku K; Bassuka-Parent A; Tatagan-Agbi K; Prince-David M; Assimadi K; CHU Tokoin, Lome, Togo.; Two cross-sectional studies were carried out in the pediatric ward of the Tokoin Teaching Hospital, Lome. One study determined the prevalence of HIV infection in the 49 malnourished patients treated in the ward in February to March and between August and December 1994. The other was carried out between July 1994 and J
[Current status of the female condom in Africa]: Sante. 1997 Nov-Dec;7(6):405-15. Unique Identifier : AIDSLINE MED/98164240; Deniaud F; Reseau IEC-Population, Abidjan, Cote d'Ivoire.; The female condom was developed in the 1980s. It is a contraceptive device used by women that protects against both pregnancy and sexually-transmitted diseases (STDs) including HIV infection. Two studies have investigated the contraceptive effectiveness of the female condom, and it was found to be as effective as othe
[Large dams, health and nutrition in Africa: beyond the controversy]: Sante. 1997 Nov-Dec;7(6):417-22. Unique Identifier : AIDSLINE MED/98164241; Parent G; Ouedraogo A; Zagre NM; Compaore I; Kambire R; Poda JN; ORSTOM-Nutrition, Ouagadougou 01, Burkina Faso.; The population in sub-Saharan Africa is growing faster than increases in food production, resulting in a net decrease in food production per capita. The Food and Agriculture Organization has stated that there is a risk of widespread hunger which could be prevented by effective planning of water resources . However,
[LACK protein of Leishmania major: a pivotal antigen in the immune relation between host and parasite (news)]: Sante. 1997 Nov-Dec;7(6):425. Unique Identifier : AIDSLINE MED/98164243; Gangneux JP
Reflux of HTLV-I infected lymphocytes from the privileged compartment(s) to peripheral blood flow in patients with HTLV-I-associated myelopathy.: J Mol Med. 1998 Feb;76(2):117-25. Unique Identifier : AIDSLINE MED/98160313; Ijichi S; Ijichi N; Yamano Y; Hall WW; Osame M; Third Department of Internal Medicine, Faculty of Medicine, Kagoshima; University, Japan.; To understand the mechanisms involved in the pathogenesis of human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), three in vivo phenomena which have been observed in the peripheral blood of patients and differing from that in asymptomatic HTLV-I carriers must be take
Integrin receptor-targeted transfer peptides for efficient delivery of antisense oligodeoxynucleotides.: J Mol Med. 1998 Feb;76(2):126-32. Unique Identifier : AIDSLINE MED/98160314; Bachmann AS; Surovoy A; Jung G; Moelling K; Institute of Medical Virology, University of Zurich, Switzerland.; Integrin receptor-targeted transfer of oligodeoxynucleotides ODNs) by small synthetic peptides was used for improving delivery of antisense ODNs. An 18-mer phosphodiester bond containing ODN complementary to c-myb-encoded mRNA was complexed with several transfer peptides, containing as their parts two modules: (a) an
[Intestinal obstruction and necrotizing thyroiditis secondary to Pneumocystis carinii infection in a seropositive hemophiliac patient seropositive for human immunodeficiency virus]: Gastroenterol Hepatol. 1998 Jan;21(1):13-5. Unique Identifier : AIDSLINE MED/98164497; Olcoz Gonni JL; Moran Blanco A; Bahamonde Carrasco A; Alonso A; Suarez D; Gundin MJ; Munoz M; Servicio de Digestivo, Hospital de Leon.; We report a case of bowel infection by Pneumocystis carinii (PC) that presented as an acute obstruction accompanied by intestinal hemorrhage (melena) in a HIV seropositive hemophilic patient. Laparotomy followed by resection of two plaque-like jejunal tumors was performed, and intravenous therapy with pentamidine was
Clinicopathologic aspects of 8 Kaposi's sarcomas among 1009 renal transplant patients.: Gen Diagn Pathol. 1997 Dec;143(4):209-13. Unique Identifier : AIDSLINE MED/98149596; Szende B; Toth A; Perner F; Nagy K; Takacs K; 1st Institute of Pathology and Experimental Cancer Research,; Semmelweis University Medical School, Budapest, Hungary.; bszende@korb1.sote.hu; In 8 of 1009 patients receiving renal grafts and consecutive immunosuppressive therapy during the last 20 years in Budapest, Hungary , Kaposi s sarcoma developed 6.5 months (average) after transplantation. Of 8 cutaneous cases of thi
Pseudoangiomatous hyperplasia of mammary stroma in an HIV patient.: Gen Diagn Pathol. 1997 Dec;143(4):251-4. Unique Identifier : AIDSLINE MED/98149604; de Saint Aubain Somerhausen N; Larsimont D; Cluydts N; Heymans O; Verhest A; Department of Pathology, Institut Jules Bordet, Bruxelles, Belgium.; averhest@ben.vub.ac.be; Pseudoangiomatous hyperplasia of the mammary stroma is a benign mesenchymal proliferative lesion. It is rarely observed as a tumor mass that has to be differentiated from angiosarcoma. We give a review of the literature and report a case unusual in that it occurred in a clinical setting of HIV infection, was rapidly g
[Seroprevalence of hepatitis C virus infection at the time of entry to prison in the prison population in the north-east of Spain]: Rev Esp Salud Publica. 1998 Jan-Feb;72(1):43-51. Unique Identifier : AIDSLINE MED/98138202; BACKGROUND: Spanish prisons have a high number of inmates whose behaviour puts them at risk of being infected by hepatitis C virus (HCV). The object of this study was to establish the prevalence of this infection and its associated factors in the prison population of the north-east of S
Improving adherence with complicated medication regimens.: Med Health R I. 1998 Feb;81(2):54-7. Unique Identifier : AIDSLINE MED/98165964; Geletko SM; Rana KZ; University of Rhode Island College of Pharmacy, Kingston 02881-0809,; USA. sandgel@aol.com
[Monks against AIDS (news)]: Tidsskr Sykepl. 1998 Feb 24;86(4):43. Unique Identifier : AIDSLINE MED/98199644
Psychiatric morbidity in HIV patients.: Can J Psychiatry. 1998 Feb;43(1):51-6. Unique Identifier : AIDSLINE MED/98155851; Khouzam HR; Donnelly NJ; Ibrahim NF; VA Medical Center, Manchester, NH 03104-4098, USA.; OBJECTIVE: To provide an accessible source of clinical information related to the diagnosis and treatment of psychiatric morbidity associated with HIV infection. METHOD: A selective MEDLINE literature search was used to identify 225 relevant articles, 67 of which were selected for inclusion based upon the presence of
The ins and outs of antiviral drug transport in the brain [editorial; comment]: J Neurovirol. 1997 Dec;3(6):385-6. Unique Identifier : AIDSLINE MED/98135451; Gallo JM
The entry of antiviral and antiretroviral drugs into the central nervous system [see comments]: J Neurovirol. 1997 Dec;3(6):387-400. Unique Identifier : AIDSLINE MED/98135452; Groothuis DR; Levy RM; Department of Neurology, Northwestern University Medical School,; Evanston Hospital, Illinois 60201, USA.; The ability of antiviral and antiretroviral drugs to enter the brain is a critical issue in the treatment of many viral brain diseases, including HIV-related neurologic disease. Much of the literature concerning nucleoside analog entry into the nervous system focuses on drug levels in the cerebrospinal fluid (CSF), eq
An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis.: J Neurovirol. 1997 Dec;3(6):401-16. Unique Identifier : AIDSLINE MED/98135453; Persidsky Y; Buttini M; Limoges J; Bock P; Gendelman HE; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68198-5215, USA.; The human immunodeficiency virus type 1 (HIV)-associated dementia complex (ADC) is a neuroimmunological disorder fueled by viral replication in mononuclear phagocytes (MP) (brain macrophages and microglia). The elucidation of MP inflammatory factors involved in neurological dysfunc
Transient infection of astrocytes with HIV-1 primary isolates derived from patients with and without AIDS dementia complex.: J Neurovirol. 1997 Dec;3(6):449-54. Unique Identifier : AIDSLINE MED/98135458; Brengel-Pesce K; Innocenti-Francillard P; Morand P; Chanzy B; Seigneurin JM; Laboratoire de Virologie-RHAP, Faculte de Medecine de Grenoble, La; Tronche, France.; We have studied the replication capacity of primary HIV-1 isolates obtained from four AIDS patients in astrocytes. Two patients (P1 and P2) had neurological manifestations without AIDS Dementia Complex (ADC). The other two patients (P3 and P4) had ADC. Two astrocytoma cell lines and normal fetal astrocytes were inocul
C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells.: J Neurovirol. 1997 Dec;3(6):455-9. Unique Identifier : AIDSLINE MED/98135459; Drew PD; Gado AM; Canning RD; Nagle JW; Dehejia AM; Polymeropoulos MH; Biddison WE; Jacobson S; Becker KG; Neuroimmunology Branch, NCHGR National Institutes of Health, Bethesda,; Maryland 20892, USA.; We report the cloning and characterization of a novel cDNA termed C2H2-546 which encodes a C2H2-type zinc finger protein. C2H2-546 RNA is expressed in the HTLV-1 infected T cells examined which were derived from HAM-TSP patients, but not in T cells derived from ATL patients. The C2H2-546 gene is conserved in humans an
Clinical manifestations and therapies of AIDS associated tumors.: Eur J Med Res. 1998 Mar 23;3(3):127-47. Unique Identifier : AIDSLINE MED/98171582; Brockmeyer N; Barthel B; Essen University Hospital, Department of Dermatology, Venerology, and; Allergology, Hufelandstr. 55, Essen, D-45147, Germany.; n.brockmeyer@uni-essen.de; We are giving an overview over the clinical features and different therapeutic options of HIV associated malignancies. There are three AIDS-defining malignancies: - Kaposi s sarcoma - Non-Hodgkin s lymphoma (NHL) - cervical cancer. In Kaposi sarcoma there is a broad therapeutic spectrum from cryotherapy to systemic ch
Two-dimensional NMR spectroscopy of peptides on beads.: J Magn Reson. 1997 Mar;125(1):185-7. Unique Identifier : AIDSLINE MED/98190563; Jelinek R; Valente AP; Valentine KG; Opella SJ; Department of Chemistry, University of Pennsylvania, Philadelphia; 19104, USA.
CD30-regulated apoptosis in murine CD8 T cells after cessation of TCR signals.: Cell Immunol. 1997 Dec 15;182(2):125-36. Unique Identifier : AIDSLINE MED/98189269; Telford WG; Nam SY; Podack ER; Miller RA; Department of Pathology, University of Michigan Medical School, Ann; Arbor, USA.; A variety of culture systems have been developed to study mechanisms of activation-induced cell death in peripheral T lymphocytes either during the initial period after exposure to an activating stimulus or following repeated stimulation of activated T cells. In this study we describe a new culture model for the analy
Generation of stable CD4+ and CD8+ T cell lines from patients immunized with ras oncogene-derived peptides reflecting codon 12 mutations.: Cell Immunol. 1997 Dec 15;182(2):137-51. Unique Identifier : AIDSLINE MED/98189270; Abrams SI; Khleif SN; Bergmann-Leitner ES; Kantor JA; Chung Y; Hamilton JM; Schlom J; Laboratory of Tumor Immunology and Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-1750, USA.; Previous studies have identified and characterized both murine in vivo and human in vitro T cell responses reflecting specific mutations in the ras proto-oncogenes at codon 12, 13, or 61. In an attempt to determine whether peptide epitopes reflecting point mutations in the ras oncogenes are immunogenic in humans for t
Partial signaling by cytokines: cytokine regulation of cell cycle and Fas-dependent, activation-induced death in CD4+ subsets.: Cell Immunol. 1997 Dec 15;182(2):152-60. Unique Identifier : AIDSLINE MED/98189271; Wang R; Ciardelli TL; Russell JH; Department of Molecular Biology and Pharmacology, Washington; University Medical School, St. Louis, Missouri 63110, USA.; Fas-dependent, activation-induced death (AID) of T cells has been implicated in the regulation of peripheral T cell populations. We have previously reported that IL-2 plays a unique role in regulating sensitivity to AID in primary CD4+ cells. In this report we have com
Regulatory cells generated by testicular tolerization to retinal S-antigen: possible involvement of IL-4, IL-10, and TGF-beta in the suppression of experimental autoimmune uveoretinitis.: Cell Immunol. 1997 Dec 15;182(2):89-98. Unique Identifier : AIDSLINE MED/98189265; Yotsukura J; Huang H; Singh AK; Shichi H; Department of Ophthalmology, Wayne State University, School of; Medicine, Detroit, Michigan 48201, USA.; Intratesticular injection of a retinal protein (S-antigen) into Lewis rats induces systemic immunotolerance (designated orchidic tolerance) and renders animals refractory to experimental autoimmune uveoretinitis (EAU) produced by S-antigen immunization. We demonstrated in this work that the immunotolerance could be tr
Immunotherapy with low-dose interleukin-2: rationale for prevention of immune-deficiency-associated cancer.: Cancer J Sci Am. 1997 Dec;3 Suppl 1:S129-36. Unique Identifier : AIDSLINE MED/98118734; Khatri VP; Baiocchi RA; Bernstein ZP; Caligiuri MA; Division of Surgery, Roswell Park Cancer Institute, Buffalo, New York,; USA.; PURPOSE: Congenital, acquired, and some iatrogenically induced immune deficiencies are characterized by an increased incidence of viral-associated cancers. Preclinical and clinical studies were conducted to understand the pathogenesis of immune-deficiency-associated cancer and its response to low-dose recombinant inte
Rational interleukin-2 therapy.: Cancer J Sci Am. 1997 Dec;3 Suppl 1:S137-40. Unique Identifier : AIDSLINE MED/98118735; Smith KA; Immunology Program, Graduate School of Medical Sciences, Cornell; University, USA.; The administration of cytokines that augment the function of the immune system can be accomplished safely and without toxicity, provided a rational approach is used. Such a therapeutic method should be based upon the principles of pharmacology and the structure-activity relationships of the cytokine-receptor interacti
Antimicrobial resistance in gonococci isolated from patients and from commercial sex workers in Harare, Zimbabwe.: Int J Antimicrob Agents. 1997 Jan;9(3):175-9. Unique Identifier : AIDSLINE MED/98186599; Mason PR; Gwanzura L; Latif AS; Marowa E; Ray S; Katzenstein DA; University of Zimbabwe Medical School, Harare. zapp@healthnet.zw; The objective is to compare antibiotic resistance amongst gonococci isolated from different patient groups in Harare, Zimbabwe . Antimicrobial susceptibilities of Neisseria. gonorrhoeae were determined by disc sensitivity tests. The MICs for penicillin, kanamycin, ceftriaxone, nor
Combined somatic and psychiatric care--effects on personnel treating drug addicts with infectious diseases.: J Occup Health Psychol. 1997 Jul;2(3):263-72. Unique Identifier : AIDSLINE MED/98177721; Ahlberg-Hulten G; Theorell T; Department of Occupational Health, Karolinska Hospital, Stockholm,; Sweden.; Infectious disease care, psychiatric care of drug addicts, and social care were combined in a ward for drug addicts with infectious diseases. The aim of this study was to evaluate the effects on the personnel (n = 22). One ward with infectious disease care of HIV and AIDS patients (n = 24) and another with nonsomatic
An exploration into occupational stress experienced by HIV health care professionals who work within genitourinary medicine settings.: J Occup Health Psychol. 1998 Jan;3(1):83-9. Unique Identifier : AIDSLINE MED/98177698; Huengsberg M; Vedhara K; Nott KH; Bradbeer C; Department of Genitourinary Medicine, Whittall Street Clinic,; Birmingham, United Kingdom.; The present study investigates the occupational stress of health care workers involved with HIV care in genitourinary medicine GUM) outpatient departments. Sixteen nursing and 14 medical staff completed the P. Gray-Toft and J. G. Anderson (1981) occupational stress inventory. This assesses 7 potential sources of stres
Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients.: Clin Chem. 1998 Apr;44(4):858-62. Unique Identifier : AIDSLINE MED/98213162; Huengsberg M; Winer JB; Gompels M; Round R; Ross J; Shahmanesh M; Department of GU Medicine, Whittall Street Clinic, Birmingham, UK.; Mia@di-ren.demon.co.uk; An alternative pathway of Trp metabolism involves the conversion of Trp to kynurenine by indoleamine-2,3-dioxygenase, which leads to synthesis of the neurotoxin, quinolinic acid. This study explores the relationship of indoleamine-2,3-dioxygenase activity with stages of HIV infection. Sera from 206 HIV-positive and 72
Echocardiographic detection of Kaposi's sarcoma causing cardiac tamponade in a patient with acquired immunodeficiency syndrome.: Clin Cardiol. 1998 Feb;21(2):131-3. Unique Identifier : AIDSLINE MED/98150921; Chyu KY; Birnbaum Y; Naqvi T; Fishbein MC; Siegel RJ; Division of Cardiology, Cedars-Sinai Medical Center, University of; California Los Angeles, 90048, USA.; Pericardial effusions are common in patients with acquired immunodeficiency syndrome (AIDS). The differential diagnosis is diverse, and in most cases the etiology cannot be established. A cardiac tamponade was diagnosed in a 32-year-old male with AIDS and systemic Kaposi s sarcoma. Transthoracic echocardiography revea
Lack of evidence of transmission of HIV-1 to family contacts of HIV-1 infected children.: Clin Pediatr (Phila). 1998 Mar;37(3):175-8. Unique Identifier : AIDSLINE MED/98207215; Courville TM; Caldwell B; Brunell PA; Division of Pediatric Infectious Diseases, Ahmanson Pediatric Center,; Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Although a number of studies have documented that casual household contact does not result in the transmission of HIV, isolated cases of person-to-person transmission have been reported. We report a study of household transmission in which the families were unaware the children were infected with HIV and thus took no
Antiretroviral therapy: an update.: Conn Med. 1998 Jan;62(1):25-8. Unique Identifier : AIDSLINE MED/98170449; Reddy P; Ross J; Hartford Hospital, Connecticut, USA.
Serologic testing of cornea donors.: Cornea. 1998 Mar;17(2):123-8. Unique Identifier : AIDSLINE MED/98179007; Glasser DB; Patuxent Medical Group, Columbia, Maryland 21045, USA.; PURPOSE: To review the current requirements and rationale for serologic testing of cornea donors and to provide guidelines for dealing with results of nonrequired tests. METHODS: Eye Bank Association of America (EBAA) and Food and Drug Administration FDA ) regulations are examined with
Chromosomal assignment of human endogenous retrovirus K (HERV-K) env open reading frames.: Cytogenet Cell Genet. 1997;79(1-2):157-61. Unique Identifier : AIDSLINE MED/98194233; Mayer J; Meese E; Mueller-Lantzsch N; Abt. Virologie, Institut fur Medizinische Mikrobiologie und Hygiene,; Universitatskliniken des Saarlandes, Homburg/Saar, Germany.; The haploid human genome contains at least one human endogenous retrovirus K (HERV-K) env gene displaying an open reading frame, as evidenced by the high antibody titers against HERV-K Env in germ cell tumor patients at the time of tumor detection. However, the chromosomal assignment of an intact HERV-K env sequence i
[Determinations of antiovarian antibodies and cellular immunity functions in patients with premature ovarian failure]: Chung Hua Fu Chan Ko Tsa Chih. 1996 Oct;31(10):603-5. Unique Identifier : AIDSLINE MED/97421026; Huang Q; Liu Q; Wu J; Nanjing General Hospital in Nanjing Area of PLA.; OBJECTIVE: To investigate the variations of cellular immunity function and its relationship with antiovarian antibodies (AOAb) in patients with premature ovarian failure (POF). METHODS: Serum AOAb, T-lymphocyte subsets and leukocyteprocoagulant activity LPCA) to ovarian antigens of peripheral blood were examined in 30
The importance of oral care in HIV infection.: Chronicle. 1994 May;57(3):38. Unique Identifier : AIDSLINE MED/98188934; Durham TM
AIDS [news]: Chronicle. 1994 May;57(3):44. Unique Identifier : AIDSLINE MED/98188935; deShazer DO
AIDS update [news]: Chronicle. 1995 May;58(3):38. Unique Identifier : AIDSLINE MED/98188931; deShazer DO
Isolation of processed, H-2Kb-binding ovalbumin-derived peptides associated with the stress proteins HSP70 and gp96.: Eur J Immunol. 1998 Mar;28(3):1016-21. Unique Identifier : AIDSLINE MED/98202678; Breloer M; Marti T; Fleischer B; von Bonin A; Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.; Stress-induced proteins or heat shock proteins (HSP) of 96 kDa mass (gp96) and 70 kDa mass (HSP70) have been shown previously to elicit specific immunity to tumors from which they are isolated. This immunity is dependent on CD8+ cytotoxic T cells which are readily primed in vivo by immunization with HSP. The immunizat
Fibronectin-binding protein I of Streptococcus pyogenes is a promising adjuvant for antigens delivered by mucosal route.: Eur J Immunol. 1998 Mar;28(3):1069-77. Unique Identifier : AIDSLINE MED/98202684; Medina E; Talay SR; Chhatwal GS; Guzman CA; Division of Microbiology, GBF-National Research Centre for; Biotechnology, Braunschweig, Germany.; A common problem in human vaccinology is the limited availability of efficient and non-toxic adjuvants capable of promoting mucosal responses. The potential usefulness of fibronectin-binding protein I (Sfbl) of Streptococcus pyogenes as immunological adjuvant was assessed using ovalbumin (OVA) as a model antigen. Mice
Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens.: Eur J Immunol. 1998 Mar;28(3):1089-103. Unique Identifier : AIDSLINE MED/98202686; Kim JJ; Trivedi NN; Nottingham LK; Morrison L; Tsai A; Hu Y; Mahalingam S; Dang K; Ahn L; Doyle NK; Wilson DM; Chattergoon MA; Chalian AA; Boyer JD; Agadjanyan MG; Weiner DB; Department of Chemical Engineering, University of Pennsylvania,; Philadelphia, USA.; Immunization with nucleic acids has been shown to induce both antigen-specific cellular and humoral immune responses in vivo. We hypothesize that immunization with DNA could be enhanced by directing specific immune responses induced by the vaccine based on the differential correlates of protection known for a particul
Percutaneous sensitization with allergens through barrier-disrupted skin elicits a Th2-dominant cytokine response.: Eur J Immunol. 1998 Mar;28(3):769-79. Unique Identifier : AIDSLINE MED/98202651; Kondo H; Ichikawa Y; Imokawa G; Biological Science Laboratory, Kao Corporation, Tochigi, Japan.; We investigated whether percutaneous sensitization with different allergens through barrier-disrupted skin regulates the balance of Th1/Th2 cytokine expression. When mice were sensitized with the typical hapten picryl chloride (PiCl) by a single topical application to intact skin, there was an up-regulation in the lym
Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses.: Eur J Immunol. 1998 Mar;28(3):881-90. Unique Identifier : AIDSLINE MED/98202664; Kim YJ; Kim SH; Mantel P; Kwon BS; Department of Microbiology and Immunology, Indiana University School; of Medicine, Indianapolis, USA.; Our present study provides evidence that the 4-1BB signal is critical to CD28 co-stimulation in maintaining T cell activation when CD28 has been down-regulated because of repeated stimulation. The 4-1BB signal synergized with CD28 co-stimulation by lowering the threshold of anti-CD28 required to sustain proliferation
Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants.: Eur J Immunol. 1998 Mar;28(3):914-25. Unique Identifier : AIDSLINE MED/98202668; Akdis CA; Blesken T; Wymann D; Akdis M; Blaser K; Swiss Institute of Allergy and Asthma Research, Davos, Switzerland.; akdisac@siaf.unizh.ch; Bee venom phospholipase A2 (PLA) represents the major allergen and antigen in allergic and non-allergic individuals sensitized to bee sting. We have studied specific activation of peripheral T cells by different structural and conformational variants of PLA and secretion of cytokines regulating IgE and IgG4 antibody (
CD4/CD8 ratios in bronchoalveolar lavage fluid: of value for diagnosing sarcoidosis? [editorial; comment]: Eur Respir J. 1997 Dec;10(12):2699-700. Unique Identifier : AIDSLINE MED/98152639; Costabel U
The CD4/CD8 ratio in BAL fluid is highly variable in sarcoidosis [see comments]: Eur Respir J. 1997 Dec;10(12):2716-21. Unique Identifier : AIDSLINE MED/98152643; Kantrow SP; Meyer KC; Kidd P; Raghu G; Division of Pulmonary and Critical Care Medicine, Dept of Medicine,; University of Washington Medical Center, Seattle 98195-6522, USA.; Patients with pulmonary sarcoidosis frequently have increased numbers of lymphocytes and a high ratio of CD4+ to CD8+ T-lymphocytes (CD4/CD8 ratio) in bronchoalveolar lavage (BAL) fluid. Some investigators have suggested that these parameters can be used to distinguish sarcoidosis from other types of interstitial lung
Pulmonary fibrosis with predominant CD8 lymphocytic alveolitis and anti-Jo-1 antibodies.: Eur Respir J. 1997 Dec;10(12):2907-12. Unique Identifier : AIDSLINE MED/98152678; Sauty A; Rochat T; Schoch OD; Hamacher J; Kurt AM; Dayer JM; Nicod LP; Dept of Internal Medicine, University Hospital, Geneva, Switzerland.; Interstitial lung disease (ILD) is a complication of polymyositis PM) and dermatomyositis (DM). It often manifests itself in association with myositis-specific antisynthetase autoantibodies, among which anti-Jo-1 antibodies are the most commonly encountered. In contrast, ILD associated with anti-Jo-1 antibodies withou
Large quantity production with extreme convenience of human SDF-1alpha and SDF-1beta by a Sendai virus vector.: FEBS Lett. 1998 Mar 20;425(1):105-11. Unique Identifier : AIDSLINE MED/98200085; Moriya C; Shioda T; Tashiro K; Nagasawa T; Ikegawa M; Ohnishi Y; Kato A; Hu H; Xin X; Hasan MK; Maekawa M; Takebe Y; Sakai Y; Honjo T; Nagai Y; Department of Viral Infection, Institute of Medical Science,; University of Tokyo, Japan.; We describe a robust expression of human stromal cell-derived factor-1alpha (SDF-1alpha) and SDF-1beta, the members of CXC-chemokine family, with a novel vector system based upon Sendai virus, a non-segmented negative strand RNA virus. Recombinant SDF-1alpha and SDF-1beta were detected as a major protein species in cu
Reporting adverse drug reactions in HIV infection [editorial]: Genitourin Med. 1997 Oct;73(5):335. Unique Identifier : AIDSLINE MED/98196238; Arlett PR; Lee EH; Hooker M; Darbyshire JH; Breckenridge AM
From human immunodeficiency virus (HIV) infection of the brain to dementia.: Genitourin Med. 1997 Oct;73(5):343-7. Unique Identifier : AIDSLINE MED/98196240; Trillo-Pazos G; Everall IP; Department of Neuropathology, Institute of Psychiatry, London.; Human immunodeficiency virus (HIV) can cause both primary and secondary brain diseases. Numerous neuropathological studies have shown that up to 90% of patients with acquired immune deficiency syndrome (AIDS) have lesions in the nervous system. In this review, we discuss the entry of HIV into the brain, the general fe
Direct estimates of prevalent HIV infection in adults in England and Wales for 1991 and 1993: an improved method.: Genitourin Med. 1997 Oct;73(5):348-54. Unique Identifier : AIDSLINE MED/98196241; Petruckevitch A; Nicoll A; Johnson AM; Bennett D; Department of Sexually Transmitted Diseases, University College London; Medical School.; OBJECTIVE: To estimate the number of prevalent HIV infections in England and Wales at the end of 1991 and 1993. METHOD: A direct method was used whereby population estimates derived from the National Survey of Sexual Attitudes and Lifestyle (NATSAL) and prevalence data from the Unlinked Anonymous HIV Prevalence Monito
Therapy for genital herpes in immunocompromised patients: a national survey. The Herpes Simplex Advisory Panel.: Genitourin Med. 1997 Oct;73(5):391-3. Unique Identifier : AIDSLINE MED/98196250; Scoular A; Barton S; Department of Genitourinary Medicine and Sexual Health, Glasgow Royal; Infirmary.; OBJECTIVES: To estimate the extent of aciclovir refractory herpes simplex virus (HSV) infection in HIV coinfected patients in the United Kingdom and survey clinicians on their approaches to its management. DESIGN: Questionnaire survey of representative sample of one third of United Kin
Condylomata acuminata of the penis progressing rapidly to invasive squamous cell carcinoma.: Genitourin Med. 1997 Oct;73(5):402-3. Unique Identifier : AIDSLINE MED/98196254; Sanders CJ; Health Services Department, Bulawayo, Zimbabwe.
Haemolytic uraemic syndrome complicated by disseminated extraneural cryptococcosis [clinical conference]: Genitourin Med. 1997 Oct;73(5):410-4. Unique Identifier : AIDSLINE MED/98196256; Pozniak AL; Lucas SB; Miller RF; Department of Genitourinary Medicine, King's College School of; Medicine and Dentistry, London.
Medical Society for the Study of Venereal Disease seventy fifth spring meeting: Oxford 1997.: Genitourin Med. 1997 Oct;73(5):418-20. Unique Identifier : AIDSLINE MED/98196258; Winter A; Ross J; Department of Genitourinary Medicine, Coventry and Warwickshire; Hospital.
Stavudine induced macrocytosis [letter]: Genitourin Med. 1997 Oct;73(5):421. Unique Identifier : AIDSLINE MED/98196259; Ahmad S; Sukthankar A
Response to treatment of chronic hepatitis C with interferon alpha in patients infected with HIV-1 is associated with higher CD4+ cell count.: Infection. 1998 Jan-Feb;26(1):16-9. Unique Identifier : AIDSLINE MED/98166072; Mauss S; Klinker H; Ulmer A; Willers R; Weissbrich B; Albrecht H; Haussinger D; Jablonowski H; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Universitat Dusseldorf, Germany.; The aim of this study was to assess the efficacy and tolerance of interferon alpha (IFN alpha) treatment of chronic hepatitis C in HIV-seropositive patients. Seventeen patients with actively replicating hepatitis C were consecutively enrolled and treated with IFN alpha 5 MIU three times a week and followed up for at l
The probability of acquiring primary Toxoplasma infection in HIV-infected patients: results of an 8-year retrospective study.: Infection. 1998 Jan-Feb;26(1):20-5. Unique Identifier : AIDSLINE MED/98166073; Reiter-Owona I; Bialek R; Rockstroh JK; Seitz HM; Institut fur Medizinische Parasitologie, Universitat Bonn, Germany.; There is much hope that HIV-infected patients and AIDS patients can reckon with a prolonged survival in future. The increased survival of AIDS patients with positive Toxoplasma serology is not necessarily associated with an increased risk of developing Toxoplasma encephalitis. For HIV-infected patients with negative T
Catabolism of the human erythrocyte C3b/C4b receptor (CR1, CD35): vesiculation and/or proteolysis?: Immunopharmacology. 1997 Dec;38(1-2):129-40. Unique Identifier : AIDSLINE MED/98136601; Dervillez X; Oudin S; Libyh MT; Tabary T; Reveil B; Philbert F; Bougy F; Pluot M; Cohen JH; Laboratoire d'Immunologie, CHU Robert Debre, Reims, France.; Human erythrocytes (E) react by exocytosis of membrane vesicles to various stresses including the fixation of the membrane attack complex of Complement. E from normal individuals loose a notable proportion of their initial number of surface CR1 molecules during the ageing process. An acquired decrease of CR1 on E also
HTLV-1 associated adult T-cell leukemia in a Micronesian patient: the first reported case.: Hawaii Med J. 1998 Jan;57(1):372-4. Unique Identifier : AIDSLINE MED/98170479; Miller CF; Cumings MD; Gress FM; Berg BW; Tripler Army Medical Center, HI 96859, USA.
Kawasaki disease and the T-cell antigen receptor.: Hum Immunol. 1998 Jan;59(1):29-38. Unique Identifier : AIDSLINE MED/98205878; Jason J; Montana E; Donald JF; Seidman M; Inge KL; Campbell R; Department of Health and Human Services, Public Health Service,; Atlanta, GA, USA.; We investigated the evidence for an infectious etiology of Kawasaki disease (KD), an acute vasculitis of unknown etiology, by assessing the effects of KD on the T cell antigen receptor variable beta region families (V beta). Using 3-color flow cytometry, we studied KD patients pre- and post-intravenous gamma globulin
Individuals from multiplex insulin-dependent diabetes mellitus IDDM) families express higher levels of TCRBV2S1 than controls.: Hum Immunol. 1998 Jan;59(1):39-47. Unique Identifier : AIDSLINE MED/98205879; Craddock T; Shefta J; Gilbey SG; Lancaster FC; Boylston AW; Molecular Medicine Unit, Leeds University, St. James University; Hospital, England.; T lymphocytes recognise peptide antigens through the T cell antigen receptor, which is composed of variable alpha and beta chains. There are forty-six functional variable regions on the beta chain. In this study the expression of the T cell receptor beta-chain variable regions 2S1 and 3S1, in a large cohort of multipl
In-vitro interaction of terbinafine with amphotericin B, fluconazole and itraconazole against clinical isolates of Candida albicans.: J Antimicrob Chemother. 1998 Jan;41(1):59-65. Unique Identifier : AIDSLINE MED/98172028; Barchiesi F; Di Francesco LF; Compagnucci P; Arzeni D; Giacometti A; Scalise G; Institute of Infectious Diseases & Public Health, University of; Ancona, Italy.; A chequerboard titration broth microdilution method, performed according to the recommendations of the National Committee for Clinical Laboratory Standards, was applied to study the in-vitro interaction of terbinafine with amphotericin B, fluconazole and itraconazole against 30 strains of Candida albicans isolated fro
Organization of HIV-1 capsid proteins on a lipid monolayer.: J Biol Chem. 1998 Mar 27;273(13):7177-80. Unique Identifier : AIDSLINE MED/98184812; Barklis E; McDermott J; Wilkens S; Fuller S; Thompson D; Vollum Institute and Department of Microbiology, Oregon Health; Sciences University, Portland, Oregon 97201-3098, USA.; barklis@ohsu.edu; In an in vitro system that mimics the assembly of immature human immunodeficiency virus (HIV) particles, ordered arrays of HIV-1 capsid (CA) proteins encoded by the viral gag gene have been obtained by incubation of histidine-tagged capsid proteins His-HIVCA) beneath lipid monolayers containing the nickel-chelating li
Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat.: J Biol Chem. 1998 Mar 27;273(13):7205-9. Unique Identifier : AIDSLINE MED/98184819; Poggi A; Rubartelli A; Zocchi MR; Laboratory of Immunopathology, National Institute for Cancer Research; and Advanced Biotechnology Center, Genoa 16132, Italy.; The entry of extracellular calcium in leukocytes mediates several cellular processes; however, unlike in excitable tissues, the underlying molecular mechanisms are poorly defined. In this paper we provide phenotypical and biochemical evidence that peripheral blood-derived human dendritic cells express dihydropyridine-
Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.: J Biol Chem. 1998 Mar 27;273(13):7222-7. Unique Identifier : AIDSLINE MED/98184821; Proost P; De Meester I; Schols D; Struyf S; Lambeir AM; Wuyts A; Opdenakker G; De Clercq E; Scharpe S; Van Damme J; Laboratory of Molecular Immunology, Rega Institute for Medical; Research, University of Leuven, Minderbroedersstraat 10, B-3000; Leuven, Belgium. Paul.Proost@rega.kuleuven.ac.be; Chemokines are key players in inflammation and infection. Natural forms of the C-X-C chemokine granulocyte chemotactic protein-2 GCP-2) and the C-C chemokine regulated on activation normal T cell expressed and secreted (RANTES), which miss two NH2-terminal residues, including a Pro in the penultimate position, have be
Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells.: J Biol Chem. 1998 Mar 27;273(13):7431-40. Unique Identifier : AIDSLINE MED/98184848; Kwon H; Pelletier N; DeLuca C; Genin P; Cisternas S; Lin R; Wainberg MA; Hiscott J; Lady Davis Institute for Medical Research, McGill University,; Montreal, Quebec H3T 1E2, Canada.; Human immunodeficiency virus (HIV-1) utilizes the NF-kappaB/Rel proteins to regulate transcription through NF-kappaB binding sites in the HIV-1 long terminal repeat (LTR). Normally, NF-kappaB is retained in the cytoplasm by inhibitory IkappaB proteins; after stimulation by multiple activators including viruses, Ikappa
Insertions into the beta3-beta4 hairpin loop of HIV-1 reverse transcriptase reveal a role for fingers subdomain in processive polymerization.: J Biol Chem. 1998 Mar 27;273(13):7529-37. Unique Identifier : AIDSLINE MED/98184861; Kew Y; Olsen LR; Japour AJ; Prasad VR; Department of Microbiology & Immunology, Albert Einstein College of; Medicine, Bronx, New York 10461, USA.; Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase RT) displays a characteristic poor processivity during DNA polymerization. Structural elements of RT that determine processivity are poorly understood. The three-dimensional structure of HIV-1 RT, which assumes a hand-like structure, shows that the fing
The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women.: J Clin Endocrinol Metab. 1998 Apr;83(4):1312-8. Unique Identifier : AIDSLINE MED/98202161; Sinha-Hikim I; Arver S; Beall G; Shen R; Guerrero M; Sattler F; Shikuma C; Nelson JC; Landgren BM; Mazer NA; Bhasin S; Division of Endocrinology, Metabolism, and Molecular Medicine, Charles; R. Drew University of Medicine and Science, Los Angeles, California; 90059, USA.; Measurements of total and free testosterone levels in women have lacked precision and accuracy because of limited assay sensitivity. The paucity of normative data on total and free testosterone levels in healthy women has confounded interpretation of androgen levels in women with human immunodeficiency virus (HIV) inf
Ultra low dose interleukin-2 therapy promotes a type 1 cytokine profile in vivo in patients with AIDS and AIDS-associated malignancies.: J Clin Invest. 1998 Mar 15;101(6):1373-8. Unique Identifier : AIDSLINE MED/98171525; Khatri VP; Fehniger TA; Baiocchi RA; Yu F; Shah MH; Schiller DS; Gould M; Gazzinelli RT; Bernstein ZP; Caligiuri MA; Division of Surgery, Roswell Park Cancer Institute, Buffalo, New York; 14263, USA.; This study was undertaken to determine if prolonged daily subcutaneous administration of ultra low dose IL-2 could influence the constitutive endogenous production of a type 1 IFN-gamma) cytokine in patients with AIDS or AIDS-associated malignancies. Using a quantitati
T cells reactive to a single immunodominant self-restricted allopeptide induce skin graft rejection in mice.: J Clin Invest. 1998 Mar 15;101(6):1398-407. Unique Identifier : AIDSLINE MED/98171528; Valujskikh A; Matesic D; Gilliam A; Anthony D; Haqqi TM; Heeger PS; Department of Medicine, Cleveland Veterans Affairs Medical Center,; Case Western Reserve University, Cleveland, Ohio 44106, USA.; Alloreactive T lymphocytes can respond to foreign MHC complexed with foreign peptides through the direct pathway of allorecognition and can additionally recognize allopeptides expressed in the context of recipient (self) MHC through the indirect pathway. To better elucidate how indirect pathway-responsive CD4(+) T cel
Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes.: J Clin Invest. 1998 Apr 1;101(7):1500-8. Unique Identifier : AIDSLINE MED/98192680; Koelle DM; Posavad CM; Barnum GR; Johnson ML; Frank JM; Corey L; Department of Medicine, University of Washington, Seattle, Washington; 98195, USA. viralimm@u.washington.edu; The mechanisms involved in host clearance of symptomatic mucocutaneous herpes simplex virus (HSV) infection are unclear. We studied the functional properties of bulk cultures of skin-infiltrating lymphocytes from normal skin and serial biopsies of recurrent genital HSV-2 lesions, and compared HSV-specific and NK respo
Prevalence of markers for human immunodeficiency, hepatitis B and hepatitis C viruses in maxillofacial and oral surgery patients at Medunsa.: J Dent Assoc S Afr. 1993 Jul;48(7):377-80. Unique Identifier : AIDSLINE MED/98172607; Dreyer AF; Aspinall S; Jacobs FJ; Department of Maxillofacial and Oral Surgery, Medical University of; Southern Africa, Medunsa.; Information on the incidence of human immunodeficiency virus HIV) and hepatitis B (HBV) and C (HCV) virus infections is needed for the planning of preventative measures against the spreading of these blood borne pathogens through treatment in the clinic. A survey was conducted to determine the incidence for 180 patien
African perspectives of the oro-facial appearance of HIV/AIDS.... [editorial]: J Dent Assoc S Afr. 1994 Nov;49(11):541. Unique Identifier : AIDSLINE MED/98169694; Arendorf T; Sauer G
Dental extractions performed in HIV-positive patients [letter]: J Dent Res. 1998 Apr;77(4):533-4. Unique Identifier : AIDSLINE MED/98198861; Diz Dios P; Vazquez Garcia E; Feijoo JF
The oral effects of AIDS [letter]: J Ala Dent Assoc. 1996 Winter;80(1):40-1. Unique Identifier : AIDSLINE MED/98156308; Neiburger EJ
A randomized controlled trial evaluating nutrition counseling with or without oral supplementation in malnourished HIV-infected patients.: J Am Diet Assoc. 1998 Apr;98(4):434-8. Unique Identifier : AIDSLINE MED/98209512; Rabeneck L; Palmer A; Knowles JB; Seidehamel RJ; Harris CL; Merkel KL; Risser JM; Akrabawi SS; Department of Veterans Affairs Medical Center and the Department of; Medicine, Baylor College of Medicine, Houston, Tex 77030, USA.; OBJECTIVE: To evaluate the effects of nutrition counseling with or without oral supplementation in malnourished patients infected with the human immunodeficiency virus (HIV). DESIGN: Randomized controlled trial. SUBJECTS: HIV-infected men (n=118) who were less than 90% of usual weight for height or who had lost more t
An elemental diet containing medium-chain triglycerides and enzymatically hydrolyzed protein can improve gastrointestinal tolerance in people infected with HIV.: J Am Diet Assoc. 1998 Apr;98(4):460-2. Unique Identifier : AIDSLINE MED/98209517; Salomon SB; Jung J; Voss T; Suguitan A; Rowe WB; Madsen DC; AIDS Demonstration Project, Maricopa County Department of Health; Services, Phoenix, Ariz, USA.
Clusters of perifollicular macrophages in normal murine skin: physiological degeneration of selected hair follicles by programmed organ deletion.: J Histochem Cytochem. 1998 Mar;46(3):361-70. Unique Identifier : AIDSLINE MED/98155238; Eichmuller S; van der Veen C; Moll I; Hermes B; Hofmann U; Muller-Rover S; Paus R; Department of Dermatology, Charite, Humboldt-Universitat zu Berlin,; Berlin, Germany.; In back skin sections from adolescent C57BL/6 mice, regularly distributed, perifollicular inflammatory cell clusters (PICC) were found located around the distal noncycling portion of about 2% of all hair follicles examined. The PICC and the affected hair follicles were characterized during spontaneously developed or i
CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.: J Immunol. 1997 Dec 1;159(11):5197-200. Unique Identifier : AIDSLINE MED/98208235; Topham DJ; Tripp RA; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.; Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or perforin (P-/-). Virus-immune P+/+ and P-/- CD8+ T cells can thus function in, respectively, a Fas-/- or Fas+/+ lung environment. The obvious question is whether the P-/- CD8+ set is effect
Apoptotic cell death upon contact of CD4+ T lymphocytes with HIV glycoprotein-expressing cells is mediated by caspases but bypasses CD95 (Fas/Apo-1) and TNF receptor 1.: J Immunol. 1997 Dec 1;159(11):5246-52. Unique Identifier : AIDSLINE MED/98208242; Ohnimus H; Heinkelein M; Jassoy C; Institute for Virology and Immunobiology, Julius Maximilians; University, Wurzburg, Germany.; Loss of CD4+ T helper lymphocytes is central to the development of immunodeficiency after infection with HIV. In this study, we demonstrate that contact of primary uninfected CD4+ T lymphocytes with HIV-infected or HIV envelope glycoprotein-expressing cells results in apoptotic cell death of both uninfected and infect
TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells.: J Immunol. 1997 Dec 1;159(11):5364-71. Unique Identifier : AIDSLINE MED/98208255; Liu T; Chambers B; Diehl AD; Van Kaer L; Jondal M; Ljunggren HG; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; Immunization of C57BL/6 (B6) mice with heat-killed Sendai virus generates a Sendai virus-specific CD8+ T cell response. This suggests that APC have the capacity to take up and present exogenous (nonreplicative) Sendai virus Ag on MHC class I molecules. Little is known about the intracellular requirements for processin
Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry.: J Immunol. 1997 Dec 1;159(11):5441-9. Unique Identifier : AIDSLINE MED/98208263; Moriuchi H; Moriuchi M; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; The chemokine receptor CCR5 is a cofactor for cellular entry of macrophage-tropic strains of HIV-1. Expression of CCR5 is restricted to T cells, macrophages, and certain cell lines; however, the mechanisms controlling its expression remain largely unknown. To delineate these mechanisms, approximately 1.0 kb of DNA fro
TCR vaccines for active immunotherapy of T cell malignancies.: J Immunol. 1997 Dec 1;159(11):5516-27. Unique Identifier : AIDSLINE MED/98208272; Okada CY; Wong CP; Denney DW; Levy R; Stanford University School of Medicine, Department of Medicine, CA; 94305, USA. cokada@leland.stanford.edu; We have developed a TCR-based vaccine approach for the treatment of T cell malignancies. TCR genes were isolated from C6VL, a T cell tumor of C57BL/Ka origin. The transmembrane encoding domains of the TCR genes were replaced by sequences encoding for phosphatidylinositol-linked cell surface expression. A high expressi
Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide.: J Immunol. 1997 Dec 1;159(11):5585-93. Unique Identifier : AIDSLINE MED/98208280; Hogaboam CM; Chensue SW; Steinhauser ML; Huffnagle GB; Lukacs NW; Strieter RM; Kunkel SL; Department of Pathology, University of Michigan Medical School, Ann; Arbor 48109-0602, USA.; Pulmonary granulomatous inflammation modulated by IFN-gamma and IL-12 is also associated with augmented inducible nitric oxide synthase (NOS II). To address the role of increased nitric oxide synthesis in this model, mice received daily i.p. injections of NG-nitro-L-arginine-methyl ester (L-NAME; 8 mg/kg) during both
Priming with IL-4 and IL-13 during HIV-1 infection restores in vitro IL-12 production by mononuclear cells of HIV-infected patients.: J Immunol. 1997 Dec 1;159(11):5705-14. Unique Identifier : AIDSLINE MED/98208295; Marshall JD; Robertson SE; Trinchieri G; Chehimi J; The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104,; USA.; The production of proinflammatory cytokines can be regulated by several factors that exert activating or inhibitory effects. IL-4, IL-10, IL-13, TGF-beta, and PGE2 have demonstrated a very wide range of potent macrophage-deactivating activities and, specifically, down-regulation of the production of many proinflammato
A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis.: J Immunol. 1997 Dec 1;159(11):5715-23. Unique Identifier : AIDSLINE MED/98208296; Ugrinovic S; Mertz A; Wu P; Braun J; Sieper J; Department of Medicine, Klinikum Benjamin Franklin, Free University,; Berlin, Germany.; The reason for the high association of HLA-B27 with diseases such as ankylosing spondylitis and reactive arthritis is not clear. In reactive arthritis, the triggering bacteria are known, thus allowing investigation of their interaction with HLA-B27. CTL lines derived from five patients with Yersinia-induced reactive a
Ligation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas ligand expression.: J Immunol. 1997 Dec 1;159(11):5742-9. Unique Identifier : AIDSLINE MED/98208299; Oberg HH; Sanzenbacher R; Lengl-Janssen B; Dobmeyer T; Flindt S; Janssen O; Kabelitz D; Department of Immunology, Paul Ehrlich Institute, Langen, Germany.; Cross-linking of cell surface CD4 molecules by anti-CD4 mAb or HIV-1 gp120/anti-gp120 Ab primes resting T lymphocytes for activation-induced cell death (AICD) triggered via the CD3/TCR complex. In striking contrast, we demonstrate here that preincubation of activated human CD4+ T cells with anti-CD4 mAb consistently i
Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets.: J Immunol. 1997 Dec 15;159(12):5802-9. Unique Identifier : AIDSLINE MED/98209746; Boutin Y; Leitenberg D; Tao X; Bottomly K; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06510, USA.; We have recently shown that altered peptide ligands influence differentiation of CD4+ T cells into Th1 and Th2 subsets. In the present study, we have examined the biochemical signals in naive CD4+ T cells after priming with altered peptide ligand (APL) that correlate with differences in cytokine expression. Although w
In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets.: J Immunol. 1997 Dec 15;159(12):5834-40. Unique Identifier : AIDSLINE MED/98209749; Cua DJ; Stohlman SA; Department of Neurology, University of Southern California School of; Medicine, Los Angeles 90033, USA.; SJL mice provide an interesting paradigm to examine the role(s) of APC in the differential induction of Th1 and Th2 cells. Immunization of young male SJL mice results in the preferential induction of Th2 cells, whereas Th1 cells are induced in age-matched female or older male SJL mice. The absence of Th1 responses in
Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.: J Immunol. 1997 Dec 15;159(12):5956-63. Unique Identifier : AIDSLINE MED/98209763; Tao X; Constant S; Jorritsma P; Bottomly K; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06510, USA.; Differentiation of naive CD4 T cells into cytokine-secreting effector Th1 and Th2 cells is influenced by several factors. We have previously reported that the affinity of antigen for TCR and antigen dose can influence the differentiation of Th1 and Th2 cells. Several in vitro and in vivo models have demonstrated a rol
Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation.: J Immunol. 1997 Dec 15;159(12):5973-83. Unique Identifier : AIDSLINE MED/98209765; Vanhecke D; Verhasselt B; De Smedt M; Leclercq G; Plum J; Vandekerckhove B; University of Gent, Department of Clinical Chemistry, Microbiology and; Immunology, University Hospital Gent-Blok A, Belgium.; Mature functional CD4 or CD8 single positive (SP) thymocytes differentiate from immature CD4+ 8+ double positive (DP) precursors through a process of positive selection and terminal differentiation. To study CD4/CD8 lineage commitment, human postselection CD69+ thymocytes were separated into distinct subpopulations ba
Activation-related differences in HLA class I-bound peptides: presentation of an IL-1 receptor antagonist-derived peptide by activated, but not resting, CD4+ T lymphocytes.: J Immunol. 1997 Dec 15;159(12):5993-9. Unique Identifier : AIDSLINE MED/98209767; Frumento G; Corradi A; Ferrara GB; Rubartelli A; Servizio di Immunogenetica, Istituto Nazionale per la Ricerca sul; Cancro, Genova, Italy. frumento@sirio.cba.unige.it; We have compared by reverse phase HPLC the set of peptides eluted from HLA class I molecules in resting and activated CD4+ Jurkat cells. Two peptides were identified that are presented de novo upon activation. After sequencing, one of these peptides turned out to derive from IL-1R antagonist (IL-1Ra). In keeping with
CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes.: J Immunol. 1997 Dec 15;159(12):6009-17. Unique Identifier : AIDSLINE MED/98209769; Poccia F; Cipriani B; Vendetti S; Colizzi V; Poquet Y; Battistini L; Lopez-Botet M; Fournie JJ; Gougeon ML; Department of Biology, University of Rome Tor Vergata, Italy.; poccia@utovrm.it; Viral, bacterial, protozoal, and cancer-associated Ags elicit strong responses in human gammadelta T lymphocytes. The majority of these cells in the peripheral blood express the Vgamma9Vdelta2-encoded TCR and recognize nonpeptidic phosphoantigens without an apparent MHC restriction. We have shown that Vgamma9Vdelta2 T
Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses.: J Immunol. 1997 Dec 15;159(12):6120-30. Unique Identifier : AIDSLINE MED/98209783; Wizel B; Nunes M; Tarleton RL; Department of Cellular Biology, University of Georgia, Athens 30602,; USA.; CD8+ T lymphocytes play a critical role in immunity to Trypanosoma cruzi. However, the target molecules of this T cell subset have not been elucidated. In this work, we report the identification of an H-2Kb-restricted CTL epitope within two trypomastigote surface Ags encoded by members of the T. cruzi sialidase/trans-
Second-hand smoke is an adjuvant for T helper-2 responses in a murine model of allergy.: J Immunol. 1997 Dec 15;159(12):6169-75. Unique Identifier : AIDSLINE MED/98209789; Seymour BW; Pinkerton KE; Friebertshauser KE; Coffman RL; Gershwin LJ; Department of Immunobiology, DNAX Research Institute of Molecular and; Cellular Biology, Palo Alto, CA 94304, USA.; Epidemiologic studies have suggested that second-hand smoke increases the incidence and severity of allergies and asthma. To address this, we developed a murine model that included generation of and exposure to environmental tobacco smoke (ETS) followed by aerosolized Ag challenge. We report herein that exposure of
Identification and characterization of multiple HLA-A24-restricted HIV-1 CTL epitopes: strong epitopes are derived from V regions of HIV-1.: J Immunol. 1997 Dec 15;159(12):6242-52. Unique Identifier : AIDSLINE MED/98209798; Ikeda-Moore Y; Tomiyama H; Miwa K; Oka S; Iwamoto A; Kaneko Y; Takiguchi M; Department of Tumor Biology, Institute of Medical Science, University; of Tokyo, Japan.; HIV-1-specific CTL has a crucial role in the elimination of the virus. However, a restricted number of common HLA class I alleles has been studied for their presentation of HIV-1 CTL epitopes. We have attempted to identify HIV-1 CTL epitopes presented by HLA-A*2402 using reverse immunogenetics. Fifty-three HLA-A*2402-
Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.: J Immunol. 1997 Dec 15;159(12):6253-9. Unique Identifier : AIDSLINE MED/98209799; Ross SE; Williams RO; Mason LJ; Mauri C; Marinova-Mutafchieva L; Malfait AM; Maini RN; Feldmann M; Kennedy Institute of Rheumatology, London, United Kingdom.; Rolipram is a type IV phosphodiesterase inhibitor that suppresses inflammation and TNF-alpha production. As anti-TNF-alpha therapy is effective in rheumatoid arthritis, we investigated the effect of rolipram on collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis. Rolipram was administered after th
A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease.: J Immunol. 1997 Dec 15;159(12):6276-82. Unique Identifier : AIDSLINE MED/98209802; Plevy SE; Landers CJ; Prehn J; Carramanzana NM; Deem RL; Shealy D; Targan SR; Cedars-Sinai Division of Gastroenterology, Inflammatory Bowel Disease; Center, Los Angeles, CA 90048, USA.; Recent clinical studies of Crohn s disease patients demonstrated dramatic clinical responses following one i.v. infusion of a chimeric mAb to TNF-alpha (cA2). To assess the role of TNF-alpha in mucosal cytokine regulation, the effects of TNF-alpha on lamina propria mononuclear cell (LPMC) Th1 production were determine
TNF-alpha down-regulates type 1 cytokines and prolongs survival of syngeneic islet grafts in nonobese diabetic mice.: J Immunol. 1997 Dec 15;159(12):6298-303. Unique Identifier : AIDSLINE MED/98209805; Rabinovitch A; Suarez-Pinzon WL; Sorensen O; Rajotte RV; Power RF; Department of Medicine, University of Alberta, Edmonton, Canada.; Administration of TNF-alpha to autoimmune diabetes-prone nonobese diabetic mice and biobreeding rats inhibits diabetes development; however, the mechanism(s) of diabetes prevention by TNF-alpha has not been established. We used the model of syngeneic islet transplantation into diabetic nonobese diabetic mice to study
Dichotomous effects of beta-chemokines on HIV replication in monocytes and monocyte-derived macrophages.: J Immunol. 1998 Apr 1;160(7):3091-5. Unique Identifier : AIDSLINE MED/98189749; Kelly MD; Naif HM; Adams SL; Cunningham AL; Lloyd AR; Inflammation Research Unit, School of Pathology, University of New; South Wales, Sydney, Australia.; The role of beta-chemokines in the pathogenesis of HIV disease remains undefined. Given the potent capacities of these proteins to attract mononuclear cells to inflammatory sites, such as lymph nodes of patients with HIV disease, the effects of exposure of monocytes and monocyte-derived macrophages to beta-chemokines
Purified MHC class I and peptide complexes activate naive CD8+ T cells independently of the CD28/B7 and LFA-1/ICAM-1 costimulatory interactions.: J Immunol. 1998 Apr 1;160(7):3180-7. Unique Identifier : AIDSLINE MED/98189760; Goldstein JS; Chen T; Brunswick M; Mostowsky H; Kozlowski S; Division of Monoclonal Antibodies, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, MD 20892, USA.; goldstein@a1.cber.fda.gov; T cells play a central role in the initiation, maintenance, and regulation of the immune response. Effector responses of T cells are controlled by complex combinations of lymphokines and adhesion/costimulatory molecule signals. To isolate the effects of specific adhesion/costimulatory molecules and to define the minim
Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells.: J Immunol. 1998 Apr 1;160(7):3188-93. Unique Identifier : AIDSLINE MED/98189761; Groux H; Bigler M; de Vries JE; Roncarolo MG; Immunobiology Department, DNAX Research Institute of Molecular; Immunology and Cellular Biology, Palo Alto, CA 94304, USA.; groux@dnax.org; IL-10 is a well-documented immunosuppressant that inhibits macrophage-dependent Ag presentation and CD4+ T cell proliferation in vitro. We report that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8+ T cells when added concomitantly with the Ag
Differential susceptibility to activation-induced apoptosis among peripheral Th1 subsets: correlation with Bcl-2 expression and consequences for AIDS pathogenesis.: J Immunol. 1998 Apr 1;160(7):3194-206. Unique Identifier : AIDSLINE MED/98189762; Ledru E; Lecoeur H; Garcia S; Debord T; Gougeon ML; Departement SIDA et Retrovirus, Institut Pasteur, Paris, France.; It has been proposed that HIV infection is associated with an imbalance in Th1 and Th2 subsets. Recent reports indicate that Th1 and Th2 effectors differ in their susceptibility to activation-induced apoptosis. To determine whether increased T cell apoptosis in HIV-infected patients contributes to alterations in cytok
CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C-) to TCR/CD8 signaling in response to antigen.: J Immunol. 1998 Apr 1;160(7):3236-43. Unique Identifier : AIDSLINE MED/98189766; Curtsinger JM; Lins DC; Mescher MF; The Center for Immunology and the Department of Laboratory Medicine; and Pathology, University of Minnesota, Minneapolis 55455, USA.; Memory CD8+ T cells from mice previously primed with alloantigen alloAg) can respond in vitro to IL-2 and purified class I alloAg presented on microspheres, while no response can be detected using cells from naive mice. Similar results have been obtained using cells fr
Inhibition of an in vitro CD4+ T cell alloresponse using altered peptide ligands.: J Immunol. 1998 Apr 1;160(7):3244-50. Unique Identifier : AIDSLINE MED/98189767; Daniel C; Grakoui A; Allen PM; Department of Pathology and Center for Immunology, Washington; University School of Medicine, St. Louis, MO 63110, USA.; In this study, we explore the potential of altered peptide ligands (APLs) to modulate the alloresponse of CD4+ T cells using elements of the murine hemoglobin (Hb) Ag model. We first demonstrated that the T cell 2.102, specific for the Hb(64-76)/I-Ek complex, was alloreactive against splenocytes of the H-2p haplotype.
Functional consequences of costimulation by ICAM-1 on IL-2 gene expression and T cell activation.: J Immunol. 1998 Apr 1;160(7):3259-68. Unique Identifier : AIDSLINE MED/98189769; Zuckerman LA; Pullen L; Miller J; Committee on Immunology, Department of Molecular Genetics and Cell; Biology, University of Chicago, IL 60637, USA.; LFA-1 is a well-recognized adhesion molecule, but its role in providing costimulatory signals to T cells has remained controversial. We have compared the ability of class II-positive transfectants that do and do not coexpress ICAM-1 (ProAd and ProAd-ICAM) to activate Ag-specific Th1 clones and naive CD4-positive T cel
Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4.: J Immunol. 1998 Apr 1;160(7):3385-92. Unique Identifier : AIDSLINE MED/98189785; Moriggl R; Kristofic C; Kinzel B; Volarevic S; Groner B; Brinkmann V; Institute for Experimental Cancer Research, Tumor Biology Center,; Freiburg, Germany.; We have shown previously that human CD4+ 45RO- T cells could be primed for a Th2 phenotype independent of IL-4 if they were activated by anti-CD28 mAb plus IL-2 . If additional TCR signals were provided, the cells differentiated toward Th1 independent of IL-12. Here we
A critical role for IL-13 in resistance to intestinal nematode infection.: J Immunol. 1998 Apr 1;160(7):3453-61. Unique Identifier : AIDSLINE MED/98189793; Bancroft AJ; McKenzie AN; Grencis RK; School of Biological Science, University of Manchester, United; Kingdom. abancrof@fs1.scg.man.ac.uk; Mice in which either the IL-4 or the IL-13 gene has been disrupted (IL-4 KO and IL-13 KO) were susceptible to infection with the intestinal nematode Trichuris muris, whereas their wild-type littermates were highly resistant and expelled the parasite. IL-4 KO mice showed diminished Th2-type responses with T. muris infe
Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response.: J Immunol. 1998 Apr 1;160(7):3487-93. Unique Identifier : AIDSLINE MED/98189797; Ning Q; Brown D; Parodo J; Cattral M; Gorczynski R; Cole E; Fung L; Ding JW; Liu MF; Rotstein O; Phillips MJ; Levy G; Multiogran Transplant Program, Department of Medicine, Toronto; Hospital, University of Toronto, Ontario, Canada.; Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses. It has been previously shown to attenuate the course of fulminant hepatitis in mice produced by murine hepatitis virus strain 3. We therefore studied the effects of ribavirin on murine hepatitis virus strain
Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10.: J Immunol. 1998 Apr 1;160(7):3602-9. Unique Identifier : AIDSLINE MED/98189811; Ludviksson BR; Sneller MC; Chua KS; Talar-Williams C; Langford CA; Ehrhardt RO; Fauci AS; Strober W; Mucosal Immunity Section, Laboratory of Clinical Investigation,; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland 20892, USA. bludviksson@atlas.niaid.nih.gov; Wegener s granulomatosis (WG) is a granulomatous vasculitis that affects the upper respiratory tract, lung, and kidney. Since T cells make up a significant proportion of cells infiltrating granulomatous lesions in WG, we investigated the proliferative response and cytokine profile of T cells from these patients. PBMCs
Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.: J Immunol. 1998 Apr 1;160(7):3610-6. Unique Identifier : AIDSLINE MED/98189812; Spaeny-Dekking EH; Hanna WL; Wolbink AM; Wever PC; Kummer AJ; Swaak AJ; Middeldorp JM; Huisman HG; Froelich CJ; Hack CE; Central Laboratory of The Netherlands Red Cross Blood Transfusion; Service, Amsterdam.; Activated CTLs and NK cells induce apoptosis via multiple mechanisms, including that termed granule exocytosis. The latter pathway consists of vectorial secretion of perforin and a family of granule-associated serine proteases (granzymes) to the target cell. To establish whether granzymes are released extracellularly
Human immunodeficiency virus type 1 gp160 and gp41 binding to Candida albicans selectively enhances candidal virulence in vitro.: J Infect Dis. 1998 Apr;177(4):1057-63. Unique Identifier : AIDSLINE MED/98194605; Gruber A; Lukasser-Vogl E; Borg-von Zepelin M; Dierich MP; Wurzner R; Institut fur Hygiene, University of Innsbruck, Austria.; Previously, it has been shown that human immunodeficiency virus HIV)-1 envelope proteins gp160 and gp41 bind to Candida albicans. Whether this interaction affects candidal virulence in vitro was investigated. HIV-1 gp160 or gp120 treatment of C. albicans significantly altered neither growth nor phospholipase activity
Cerebrospinal fluid levels of biopterin, nitric oxide metabolites, and immune activation markers and the clinical course of human cerebral malaria.: J Infect Dis. 1998 Apr;177(4):1064-8. Unique Identifier : AIDSLINE MED/98194606; Weiss G; Thuma PE; Biemba G; Mabeza G; Werner ER; Gordeuk VR; Department of Internal Medicine, University Hospital, University of; Innsbruck, Austria. guenter.weiss@uibk.ac.at; Cerebrospinal fluid samples from 130 children who presented with cerebral malaria were investigated to elucidate the impact of biopterin production, NO formation, and local immune activation on the clinical course of this disease. Biopterin levels were significantly lower in patients who were in a deeper coma (P = 02)
Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus-infected patients.: J Infect Dis. 1998 Apr;177(4):1080-3. Unique Identifier : AIDSLINE MED/98194610; Tural C; Romeu J; Sirera G; Andreu D; Conejero M; Ruiz S; Jou A; Bonjoch A; Ruiz L; Arno A; Clotet B; Ophthalmologic Department, Germans Trias i Pujol University Hospital,; Badalona, Spain.; Seven AIDS patients who were receiving suppressive therapy for previously diagnosed cytomegalovirus ( CMV ) retinitis were offered treatment with protease inhibitors (PIs). S
Major expansions of select CD8+ subsets in acute Epstein-Barr virus infection: comparison with chronic human immunodeficiency virus disease.: J Infect Dis. 1998 Apr;177(4):1083-7. Unique Identifier : AIDSLINE MED/98194611; Lynne JE; Schmid I; Matud JL; Hirji K; Buessow S; Shlian DM; Giorgi JV; Department of Medicine, UCLA School of Medicine, Los Angeles,; California 90095-1745, USA.; CD8+ lymphocyte phenotypes were characterized during acute Epstein-Barr virus (EBV) infection, and a comparison was made to previous studies of human immunodeficiency virus (HIV). This was of interest because CD8+ cells contribute to immunologic control of both infections, but the usual outcome of EBV infection is ben
Natural history of Epstein-Barr virus infection in a prospective pediatric cohort born to human immunodeficiency virus-infected mothers.: J Infect Dis. 1998 Apr;177(4):1087-90. Unique Identifier : AIDSLINE MED/98194612; Pedneault L; Lapointe N; Alfieri C; Ghadirian P; Carpentier L; Samson J; Joncas J; Department of Microbiology and Infectious Diseases, Research Center,; and Centre Maternel et Infantile sur le SIDA, Hopital Sainte-Justine,; Montreal, Canada. LP88709@glaxowellcome.com; To determine whether Epstein-Barr virus (EBV) constitutes a contributing factor in AIDS and, conversely, whether the human immunodeficiency virus (HIV) alters the course of primary EBV infection in a pediatric population, 62 children born to HIV-infected mothers and prospectively followed were evaluated. EBV infection
Circulating levels of RANTES in human immunodeficiency virus type 1 infection: effect of potent antiretroviral therapy.: J Infect Dis. 1998 Apr;177(4):1091-6. Unique Identifier : AIDSLINE MED/98194613; Aukrust P; Muller F; Froland SS; Research Institute for Internal Medicine, Medical Department A,; University of Oslo, Rikshospitalet, Norway. pal.aukrust@klinmed.uio.no; RANTES has been found to suppress human immunodeficiency virus type 1 (HIV-1) replication. To further elucidate the role of this chemokine in HIV-1 infection, RANTES levels were analyzed in serum and platelet-free plasma (PFP) in 53 HIV-1-infected patients and 20 controls. RANTES levels were significantly elevated in
Intrapartum mucosal exposure to human immunodeficiency virus type 1 (HIV-1) of infants born to HIV-1-infected mothers correlates with maternal plasma virus burden.: J Infect Dis. 1998 Apr;177(4):1097-100. Unique Identifier : AIDSLINE MED/98194614; Ait-Khaled M; Lyall EG; Stainsby C; Taylor GP; Wright A; Weber JN; McClure MO; Tudor-Williams G; Department of Genito-Urinary Medicine, and Communicable Diseases,; Jefferiss Research Trust Laboratories, London, United Kingdom.; The majority of vertical infections with human immunodeficiency virus type 1 (HIV-1) occur at or near delivery, strongly suggesting a mucosal route of transmission. The frequency and level of intrapartum mucosal exposure to HIV-1 of 22 infants born to infected mothers was investigated. Maternal plasma HIV-1 RNA and CD
Human immunodeficiency virus type 1 RNA shedding in the female genital tract.: J Infect Dis. 1998 Apr;177(4):1100-3. Unique Identifier : AIDSLINE MED/98194615; Goulston C; McFarland W; Katzenstein D; Division of Infectious Diseases and Geographic Medicine, Stanford; University, California 94305-5107, USA.; Cervical and plasma samples obtained twice, at 2-week intervals, from 49 human immunodeficiency virus type 1 (HIV-1)-positive women were assayed for HIV-1 RNA. More than 100 copies of HIV-1 RNA were detected in cervical swab supernatants (CSS) from 24 49%) of 49 women. HIV-1 RNA in CSS was detected in younger women wi
Dissemination of Mycobacterium tuberculosis across the San Francisco Bay Area.: J Infect Dis. 1998 Apr;177(4):1104-7. Unique Identifier : AIDSLINE MED/98194616; Bradford WZ; Koehler J; El-Hajj H; Hopewell PC; Reingold AL; Agasino CB; Cave MD; Rane S; Yang Z; Crane CM; Small PM; Medical Service, San Francisco General Hospital, and University of; California 94110, USA. bill@itsa.ucsf.edu; The propensity of Mycobacterium tuberculosis genotypes to spread across geographic boundaries was investigated by comparing the IS6110 and polymorphic GC-rich sequence patterns of M. tuberculosis isolates from San Francisco and the East Bay, two distinct regions separated by San Francisco Bay. Of 724 isolates from inc
Stability of Mycobacterium tuberculosis DNA genotypes.: J Infect Dis. 1998 Apr;177(4):1107-11. Unique Identifier : AIDSLINE MED/98194617; Yeh RW; Ponce de Leon A; Agasino CB; Hahn JA; Daley CL; Hopewell PC; Small PM; Department of Medicine, Stanford University School of Medicine, CA; 94305, USA.; To assess genotype stability in Mycobacterium tuberculosis, DNA genotypes were compared in sequential isolates from 49 patients who had sputum cultures separated by at least 90 days that grew M. tuberculosis. By use of IS6110 and the polymorphic GC-rich sequence (PGRS) as markers, it was found that paired isolates fro
Human herpesvirus 8 group B and C variants circulating in Sao Paulo, Brazil [letter]: J Infect Dis. 1998 Apr;177(4):1136-7. Unique Identifier : AIDSLINE MED/98194624; Caterino-de-Araujo A
Drug-susceptible tuberculosis [letter]: J Infect Dis. 1998 Apr;177(4):1138-9. Unique Identifier : AIDSLINE MED/98194625; Munsiff SS; Driver C
In vivo production of cytokines and beta (C-C) chemokines in human recurrent herpes simplex lesions--do herpes simplex virus-infected keratinocytes contribute to their production?: J Infect Dis. 1998 Apr;177(4):827-38. Unique Identifier : AIDSLINE MED/98194576; Mikloska Z; Danis VA; Adams S; Lloyd AR; Adrian DL; Cunningham AL; Centre for Virus Research, Westmead Institutes of Health Research,; NSW, Australia. zorkam@westmed.wh.su.edu.au; Recurrent human herpes simplex lesions are infiltrated by macrophages and CD4 and CD8 lymphocytes, which secrete cytokines and chemokines. Vesicle fluid was examined by ELISA for the presence of cytokines and beta (C-C) chemokines. On the first day of the lesion, high concentrations of interleukin (IL)-1beta, and IL-6
The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus.: J Infect Dis. 1998 Apr;177(4):839-47. Unique Identifier : AIDSLINE MED/98194577; Saiz JC; Lopez-Labrador FX; Ampurdanes S; Dopazo J; Forns X; Sanchez-Tapias JM; Rodes J; Hospital Clinic, Department of Medicine, Facultad de Medicina,; Universidad de Barcelona, Spain. JCSAIZ@medicina.ub.es; Hepatitis C virus (HCV) RNA serum concentration, quasispecies complexity, and sequence and phylogenetic analysis of the nonstructural 5A gene (NS5A) interferon sensitivity determining region (ISDR) were determined in pretreatment serum samples from 47 patients with chronic hepatitis C (36 infected by HCV genotype 1b a
Absence of hepatitis C virus and detection of hepatitis G virus/GB virus C RNA sequences in the semen of infected men.: J Infect Dis. 1998 Apr;177(4):848-54. Unique Identifier : AIDSLINE MED/98194578; Semprini AE; Persico T; Thiers V; Oneta M; Tuveri R; Serafini P; Boschini A; Giuntelli S; Pardi G; Brechot C; Department of Obstetrics and Gynecology, San Paolo Biomedical; Institute, University of Milan Medical School, Italy. reprodun@tin.it; The identification of hepatitis C virus (HCV) in semen remains controversial and that of hepatitis G virus (HGV) or GB virus C GBV-C) has never been investigated. Serum and semen from 90 anti-HCV-positive drug users were tested (27 infected with HIV) for HCV and HGV/GBV-C RNAs by polymerase chain reaction (PCR) assay,
Passive immunization with a human immunodeficiency virus type 1-neutralizing monoclonal antibody in Hu-PBL-SCID mice: isolation of a neutralization escape variant.: J Infect Dis. 1998 Apr;177(4):889-97. Unique Identifier : AIDSLINE MED/98194583; Andrus L; Prince AM; Bernal I; McCormack P; Lee DH; Gorny MK; Zolla-Pazner S; Lindsley F. Kimball Research Institute of the New York Blood Center,; New York University Medical Center, New York 10021, USA.; landrus@NYBC.org; A monoclonal antibody (694/98-D) directed toward the V3 loop of human immunodeficiency virus type 1 (HIV-1) was evaluated for pre- and postexposure prophylaxis in SCID mice reconstituted with human peripheral blood lymphocytes (Hu-PBL-SCID). Fifty percent protection against the HIV-1LAI strain was obtained by preexpos
Improvement in cell-mediated immune function during potent anti-human immunodeficiency virus therapy with ritonavir plus saquinavir.: J Infect Dis. 1998 Apr;177(4):898-904. Unique Identifier : AIDSLINE MED/98194584; Angel JB; Kumar A; Parato K; Filion LG; Diaz-Mitoma F; Daftarian P; Pham B; Sun E; Leonard JM; Cameron DW; Department of Medicine, University of Ottawa, Canada. jangel@ogh.on.ca; Inhibiting human immunodeficiency virus (HIV) replication with potent antiretroviral therapy may result in improved immune function, and this may lead to favorable outcomes, independent of changes in CD4+ lymphocyte count. The effect of combination protease inhibitor therapy (
gp41 envelope protein of human immunodeficiency virus induces interleukin (IL)-10 in monocytes, but not in B, T, or NK cells, leading to reduced IL-2 and interferon-gamma production.: J Infect Dis. 1998 Apr;177(4):905-13. Unique Identifier : AIDSLINE MED/98194585; Barcova M; Kacani L; Speth C; Dierich MP; Institute for Hygiene, University of Innsbruck and; Ludwig-Boltzmann-Institute for AIDS Research, Austria.; The effect of extracellular domain of human immunodeficiency virus (HIV-1) transmembrane glycoprotein gp41 on interleukin IL)-10, IL-2 , interferon (IFN)-y, IL-4, and tumor necrosis factor-alpha production by human peripheral blood mononuclear cells (PBMC) was assessed
Immunomodulatory treatment of Mycobacterium avium complex bacteremia in patients with AIDS by use of recombinant granulocyte-macrophage colony-stimulating factor.: J Infect Dis. 1998 Apr;177(4):914-20. Unique Identifier : AIDSLINE MED/98194586; Kemper CA; Bermudez LE; Deresinski SC; Department of Medicine, Santa Clara Valley Medical Center, San Jose,; California 95128, USA.; Eight AIDS patients with Mycobacterium avium complex (MAC) bacteremia were randomized to receive azithromycin with or without granulocyte-macrophage colony-stimulating factor (GM-CSF) for 6 weeks to examine the effect of GM-CSF administration on clearance of mycobacteremia and on monocyte function. Superoxide anion pr
Reduced expression of interleukin-8 receptors A and B on polymorphonuclear neutrophils from persons with human immunodeficiency virus type 1 disease and pulmonary tuberculosis.: J Infect Dis. 1998 Apr;177(4):921-30. Unique Identifier : AIDSLINE MED/98194587; Meddows-Taylor S; Martin DJ; Tiemessen CT; Medical Research Council AIDS Virus Research Unit, National Institute; for Virology, Johannesburg, South Africa.; The expression of the two human interleukin (IL)-8 receptors, designated IL-8RA (CXCR-1) and IL-8RB (CXCR-2), on the surface of whole blood polymorphonuclear leukocytes (PMNL) was determined by use of receptor-specific monoclonal antibodies and flow cytometry. Sixteen subjects each were included in 4 study groups: hea
Neurosyphilis during the AIDS epidemic, San Francisco, 1985-1992.: J Infect Dis. 1998 Apr;177(4):931-40. Unique Identifier : AIDSLINE MED/98194588; Flood JM; Weinstock HS; Guroy ME; Bayne L; Simon RP; Bolan G; Department of Medicine, University of California, San Francisco, USA.; FLOO101W@CDC.GOV; To investigate the epidemiology and clinical spectrum of neurosyphilis in a population with high rates of coexisting syphilis and human immunodeficiency virus (HIV) infection, a retrospective analysis of cases in all San Francisco hospitals from 1985 to 1992 was conducted. Neurosy
Treponema pallidum, lipoproteins, and synthetic lipoprotein analogues induce human immunodeficiency virus type 1 gene expression in monocytes via NF-kappaB activation.: J Infect Dis. 1998 Apr;177(4):941-50. Unique Identifier : AIDSLINE MED/98194589; Theus SA; Harrich DA; Gaynor R; Radolf JD; Norgard MV; Department of Microbiology, University of Texas Southwestern Medical; Center, Dallas 75235-9048, USA.; Syphilitic genital ulcers are cofactors for the bidirectional transmission of human immunodeficiency virus (HIV). U937 human promonocytic cells chronically infected with HIV-1 (U1 cells) or transiently transfected with wild type or mutant HIV long terminal repeat (LTR) reporter constructs were used to examine mechanis
Development of quinolone-resistant Campylobacter fetus bacteremia in human immunodeficiency virus-infected patients.: J Infect Dis. 1998 Apr;177(4):951-4. Unique Identifier : AIDSLINE MED/98194590; Meier PA; Dooley DP; Jorgensen JH; Sanders CC; Huang WM; Patterson JE; Department of Infectious Diseases, Wilford Hall Medical Center, Ft.; Sam Houston, TX, USA.; Campylobacter fetus subspecies fetus has been recognized as a cause of systemic illness in immunocompromised hosts, including relapsing bacteremia in human immunodeficiency virus HIV)-infected patients. Acquired resistance to quinolone therapy, while reported for a variety of bacteria, including Campylobacter jejuni,
[A chemokine PBSF/SDF-1 and its receptor CXCR4: function and involvement in HIV-1 infection]: Seikagaku. 1997 Dec;69(12):1373-8. Unique Identifier : AIDSLINE MED/98144976; Nagasawa T; Research Institute, Osaka Medical Center for Maternal and Child; Health.
Knowledge, attitudes, and practices of senior high school students regarding human immunodeficiency virus infection.: J Med Assoc Thai. 1998 Feb;81(2):130-5. Unique Identifier : AIDSLINE MED/98190748; Tuchinda S; Chotpitayasunondh T; Teeraratkul A; Children's Hospital, Bangkok, Thailand.; A survey of knowledge, attitude and practice (KAP) regarding human immunodeficiency virus infection was performed on 899 students from 3 government-administered high schools located in the Bangkok Metropolitan area. Initially, all students completed a written questionnaire (pre-test) regarding HIV/AIDS. Following this
Cytotoxic T lymphocytes in AIDS pathogenesis: lessons to be learned from the macaque model of simian immunodeficiency virus infection.: J Gen Virol. 1998 Mar;79 ( Pt 3):415-21. Unique Identifier : AIDSLINE MED/98178633; Geretti AM; Hulskotte E; Osterhaus AD; Institute of Virology, Erasmus University, Rotterdam, The Netherlands.; geretti@rfhsm.ac.uk
Evaluation of a candidate human immunodeficiency virus type 1 HIV-1) vaccine in macaques: effect of vaccination with HIV-1 gp120 on subsequent challenge with heterologous simian immunodeficiency virus-HIV-1 chimeric virus.: J Gen Virol. 1998 Mar;79 ( Pt 3):423-32. Unique Identifier : AIDSLINE MED/98178634; Stott EJ; Almond N; Kent K; Walker B; Hull R; Rose J; Silvera P; Sangster R; Corcoran T; Lines J; Silvera K; Luciw P; Murphy-Corb M; Momin P; Bruck C; Division of Retrovirology, National Institute for Biological Standards; & Control, Potters Bar, Herts, UK. jstott@nibsc.ac.uk; Human immunodeficiency virus type 1 (HIV-1) envelope vaccines can now be evaluated for efficacy in macaques by challenging with chimeric viruses in which the env, tat and rev genes of simian immunodeficiency virus (SIV) have been replaced by those of HIV-1. Most experiments have so far been conducted using gp120 molec
Substance P and histamine induce interleukin-6 expression in human astrocytoma cells by a mechanism involving protein kinase C and nuclear factor-IL-6.: J Neurochem. 1998 Apr;70(4):1577-83. Unique Identifier : AIDSLINE MED/98181719; Lieb K; Schaller H; Bauer J; Berger M; Schulze-Osthoff K; Fiebich BL; Abteilung Psychiatrie, Universitat Freiburg, Germany.; Interleukin-6 (IL-6) is a proinflammatory cytokine whose synthesis is induced by a variety of stimuli including interleukin-1 (IL-1), substance P (SP), and histamine. Because IL-6 has been implicated in the etiopathology of different human diseases including multiple myeloma, rheumatoid arthritis, multiple sclerosis,
Diagnosing HIV-related disease: using the CD4 count as a guide.: J Gen Intern Med. 1998 Feb;13(2):131-6. Unique Identifier : AIDSLINE MED/98161480; Jung AC; Paauw DS; Department of Medicine, University of Washington, Seattle 98195-6420,; USA.; OBJECTIVE: To summarize current information on the relation between CD4 counts and the risk of different HIV-related diseases. MEASUREMENTS AND MAIN RESULTS: MEDLINE search of English language articles between 1985 and 1996 using the medical subject heading (MeSH) term CD4 lymphocyte count and searches using key wor
National HIV telephone consultation line [letter]: J Gen Intern Med. 1998 Feb;13(2):146. Unique Identifier : AIDSLINE MED/98161485; Liljestrand P; Goldschmidt RH
Patients, HIV status, and confidentiality laws.: J Mich Dent Assoc. 1995 Jun;77(5):16. Unique Identifier : AIDSLINE MED/98169654; Weber RD
Responding to the challenge: the dental management of HIV.: J Mich Dent Assoc. 1995 Sep;77(7):32-4, 36-8, 40 passim. Unique Identifier : AIDSLINE MED/98169659; Chase WR
Should dentists be obligated to report their HIV status? [editorial]: J Mich Dent Assoc. 1995 Sep;77(7):6. Unique Identifier : AIDSLINE MED/98216665; Chase WR
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.: J Virol. 1998 Apr;72(4):2615-29. Unique Identifier : AIDSLINE MED/98184490; Chun RF; Semmes OJ; Neuveut C; Jeang KT; Molecular Virology Section, Laboratory of Molecular Microbiology,; National Institutes of Allergy and Infectious Diseases, Bethesda,; Maryland 20892-0460, USA.; We previously reported (K. T. Jeang, R. Chun, N. H. Lin, A. Gatignol, C. G. Glabe, and H. Fan, J. Virol. 67: 6224-6233, 1993) that human immunodeficiency virus type 1 (HIV-1) Tat and Sp1 form a protein-protein complex. Here, we have characterized the physical interaction and a functional consequence of Tat-Sp1 contact
A replication-competent retrovirus arising from a split-function packaging cell line was generated by recombination events between the vector, one of the packaging constructs, and endogenous retroviral sequences.: J Virol. 1998 Apr;72(4):2663-70. Unique Identifier : AIDSLINE MED/98184495; Chong H; Starkey W; Vile RG; Division of Histopathology, United Medical and Dental Schools of Guy's; and St. Thomas's Hospitals, London, United Kingdom.; Previously we reported the presence of a replication-competent retrovirus in supernatant from a vector-producing line derived from a widely used split-function amphotropic packaging cell line. Rigorous routine screening of all retroviral stocks produced in our laboratory has not, previously or since, indicated the pre
Mucosal immunity to herpes simplex virus type 2 infection in the mouse vagina is impaired by in vivo depletion of T lymphocytes.: J Virol. 1998 Apr;72(4):2677-85. Unique Identifier : AIDSLINE MED/98184497; Parr MB; Parr EL; School of Medicine, Southern Illinois University, Carbondale 62901,; USA. mparr@som.siu.edu; Intravaginal (IVAG) inoculation of wild-type herpes simplex virus type 2 (HSV-2) in mice causes epithelial infection followed by lethal neurological illness, while IVAG inoculation of attenuated HSV-2 causes epithelial infection followed by development of protective immunity against subsequent IVAG challenge with wild
In vivo evolution of a novel, syncytium-inducing and cytopathic feline leukemia virus variant.: J Virol. 1998 Apr;72(4):2686-96. Unique Identifier : AIDSLINE MED/98184498; Rohn JL; Moser MS; Gwynn SR; Baldwin DN; Overbaugh J; Department of Microbiology, University of Washington, Seattle 98195,; USA.; Studies of feline leukemia virus (FeLV) have illustrated the importance of the genotype of the infecting virus in determining disease outcome. In FeLV infections, as in other retroviral infections, it is less clear how virus variants that evolve from the transmitted virus affect pathogenesis. We previously reported an
The I domain is required for efficient plasma membrane binding of human immunodeficiency virus type 1 Pr55Gag.: J Virol. 1998 Apr;72(4):2723-32. Unique Identifier : AIDSLINE MED/98184502; Sandefur S; Varthakavi V; Spearman P; Department of Pediatrics, Vanderbilt University, Nashville, Tennessee; 37232-2581, USA.; The interaction of the human immunodeficiency virus type 1 HIV-1) Pr55Gag molecule with the plasma membrane of an infected cell is an essential step of the viral life cycle. Myristic acid and positively charged residues within the N-terminal portion of MA constitute the membrane-binding domain of Pr55Gag. A separate a
Immature dendritic cells selectively replicate macrophagetropic M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells.: J Virol. 1998 Apr;72(4):2733-7. Unique Identifier : AIDSLINE MED/98184503; Granelli-Piperno A; Delgado E; Finkel V; Paxton W; Steinman RM; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, New York 10021, USA.; piperno@rockvax.rockefeller.edu; Dendritic cells (DCs) can develop from CD14+ peripheral blood monocytes cultured in granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). By 6 days in culture, the cells have the characteristics of immature DCs and can be further induced to mature by inflammatory stimuli or by monocyte-co
Plasma membrane-targeted Raf kinase activates NF-kappaB and human immunodeficiency virus type 1 replication in T lymphocytes.: J Virol. 1998 Apr;72(4):2788-94. Unique Identifier : AIDSLINE MED/98184510; Flory E; Weber CK; Chen P; Hoffmeyer A; Jassoy C; Rapp UR; Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat; Wurzburg, Germany.; Increasing evidence points to a role of the mitogenic Ras/Raf/MEK/ERK signaling cascade in regulation of human immunodeficiency virus type 1 (HIV-1) gene expression. Stimulation of elements of this pathway leads to transactivation of the HIV-1 promoter. In particular, the NF-kappaB motif in the HIV long terminal repea
Specific interactions between retrovirus Env and Gag proteins in rat neurons.: J Virol. 1998 Apr;72(4):2832-45. Unique Identifier : AIDSLINE MED/98184515; Weclewicz K; Ekstrom M; Kristensson K; Garoff H; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.; In this work we have studied the intracellular localization properties of the Gag and Env proteins of Moloney murine leukemia virus (MLV) and human immunodeficiency virus (HIV) in dorsal root ganglion (DRG) neurons of rat. These neurons form thick bundles of axons, which facilitates protein localization studies by imm
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.: J Virol. 1998 Apr;72(4):2846-54. Unique Identifier : AIDSLINE MED/98184516; Wiegers K; Rutter G; Kottler H; Tessmer U; Hohenberg H; Krausslich HG; Heinrich-Pette-Institut, Hamburg, Germany.; Retroviruses are produced as immature particles containing structural polyproteins, which are subsequently cleaved by the viral proteinase (PR). Extracellular maturation leads to condensation of the spherical core to a capsid shell formed by the capsid (CA) protein, which encases the genomic RNA complexed with nucleoc
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.: J Virol. 1998 Apr;72(4):2855-64. Unique Identifier : AIDSLINE MED/98184517; Platt EJ; Wehrly K; Kuhmann SE; Chesebro B; Kabat D; Department of Biochemistry and Molecular Biology, Oregon Health; Sciences University, Portland 97201-3098, USA.; It has been proposed that changes in cell surface concentrations of coreceptors may control infections by human immunodeficiency virus type 1 (HIV-1), but the mechanisms of coreceptor function and the concentration dependencies of their activities are unknown. To study these issues and to generate stable clones of adh
The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity.: J Virol. 1998 Apr;72(4):2890-5. Unique Identifier : AIDSLINE MED/98184521; Rezende LF; Curr K; Ueno T; Mitsuya H; Prasad VR; Department of Microbiology and Immunology, Albert Einstein College of; Medicine, Bronx, New York 10461, USA.; Variants of human immunodeficiency virus type 1 (HIV-1) that are highly resistant to a number of nucleoside analog drugs have been shown to develop in some patients receiving 2 ,3 -dideoxy-3 -azidothymidine therapy in combination with 2 ,3 -dideoxycytidine or 2 ,3 -dideoxyinosine. The appearance, in the reverse transc
Functional analysis of the human immunodeficiency virus type 1 Rev protein oligomerization interface.: J Virol. 1998 Apr;72(4):2935-44. Unique Identifier : AIDSLINE MED/98184526; Thomas SL; Oft M; Jaksche H; Casari G; Heger P; Dobrovnik M; Bevec D; Hauber J; Department of Immunology, Novartis Research Institute, Vienna,; Austria.; The expression of human immunodeficiency virus type 1 (HIV-1) structural proteins requires the action of the viral trans-regulatory protein Rev. Rev is a nuclear shuttle protein that directly binds to its cis-acting Rev response element (RRE) RNA target sequence. Subsequent oligomerization of Rev monomers on the RRE a
Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus.: J Virol. 1998 Apr;72(4):2962-8. Unique Identifier : AIDSLINE MED/98184529; Ott DE; Coren LV; Copeland TD; Kane BP; Johnson DG; Sowder RC 2nd; Yoshinaka Y; Oroszlan S; Arthur LO; Henderson LE; AIDS Vaccine Program, SAIC/Frederick, National Cancer Institute,; Frederick Cancer Research and Development Center, Maryland 21702-1201,; USA. ott@avpvx1.ncifcrf.gov; Host proteins are incorporated into retroviral virions during assembly and budding. We have examined three retroviruses, human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and Moloney murine leukemia virus (Mo-MuLV), for the presence of ubiquitin inside each of these virions. After a pro
Extensive diversification of human immunodeficiency virus type 1 subtype B strains during dual infection of a chimpanzee that progressed to AIDS.: J Virol. 1998 Apr;72(4):3005-17. Unique Identifier : AIDSLINE MED/98184535; Wei Q; Fultz PN; Department of Microbiology, University of Alabama School of Medicine,; Birmingham 35294, USA.; A chimpanzee (C-499) infected for more than 9 years with two subtype B isolates of human immunodeficiency virus type 1 HIV-1), one (HIV-1(SF2)) that replicates poorly and one HIV-1(LAV-1b)) that replicates efficiently in chimpanzees, died of AIDS 11 years after initial infection (F. J. Novembre et al., J. Virol. 71:40
Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription.: J Virol. 1998 Apr;72(4):3037-44. Unique Identifier : AIDSLINE MED/98184538; Stark LA; Hay RT; School of Biomedical Sciences, Irvine Building, University of St.; Andrews, Fife, Scotland.; The vpr gene of human immunodeficiency virus type 1 (HIV-1) encodes a 96-amino-acid 14-kDa protein (viral protein R [Vpr]), which is produced late in the viral life cycle and is incorporated into the virion. Although Vpr is not required for viral replication in transformed cell lines and primary T lymphocytes, it is e
Detection of hepatitis G virus replication sites by using highly strand-specific Tth-based reverse transcriptase PCR.: J Virol. 1998 Apr;72(4):3072-5. Unique Identifier : AIDSLINE MED/98184543; Laskus T; Radkowski M; Wang LF; Vargas H; Rakela J; Division of Transplantation Medicine, Thomas E. Starzl Transplantation; Institute, University of Pittsburgh, Pennsylvania 15213, USA.; The replication sites of the recently discovered hepatitis G virus (HGV) remain unknown. Using highly strand-specific Tth-based reverse transcriptase PCR, we searched for the presence of viral RNA negative strand in multiple autopsy tissues from four patients with AIDS and in peripheral blood mononuclear cells from si
Type D retrovirus capsid assembly and release are active events requiring ATP.: J Virol. 1998 Apr;72(4):3098-106. Unique Identifier : AIDSLINE MED/98184547; Weldon RA Jr; Parker WB; Sakalian M; Hunter E; Department of Microbiology, University of Alabama at Birmingham,; 35294, USA.; Mason- Pfizer monkey virus (M-PMV), the prototype type D retrovirus, differs from most other retroviruses by assembling its Gag polyproteins into procapsids in the cytoplasm of infected cells. Once assembled, the procapsids migrate to the plasma membrane, where they acquire
Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells.: J Virol. 1998 Apr;72(4):3161-8. Unique Identifier : AIDSLINE MED/98184554; Korin YD; Zack JA; Department of Pathology and Laboratory Medicine, University of; California, Los Angeles, School of Medicine, 90095, USA.; Successful infection by human immunodeficiency virus type 1 HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile, reverse transcripts. In the present study, we isolated highly purified quiescent T cells and utilized the CD3/CD28 activa
The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity.: J Virol. 1998 Apr;72(4):3178-84. Unique Identifier : AIDSLINE MED/98184556; Chen YL; Trono D; Camaur D; Infectious Disease Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; The Nef protein of human immunodeficiency virus type 1 (HIV-1) promotes virion infectivity through mechanisms that are yet ill defined. Some Nef is incorporated into particles, where it is cleaved by the viral protease between amino acids 57 and 58. The functional significance of this event, which liberates the C-term
The bovine leukemia virus encapsidation signal is composed of RNA secondary structures.: J Virol. 1998 Apr;72(4):3196-204. Unique Identifier : AIDSLINE MED/98184558; Mansky LM; Wisniewski RM; Department of Medical Microbiology and Immunology, Creighton; University School of Medicine, Omaha, Nebraska 68178, USA.; mansky.3@osu.edu; The encapsidation signal of bovine leukemia virus (BLV) was previously shown by deletion analysis to be discontinuous and to extend into the 5 end of the gag gene (L. Mansky et al., J. Virol. 69:3282-3289, 1995). The global minimum-energy optimal folding for the entire BLV RNA, including the previously mapped primary
Synergistic neutralization of simian-human immunodeficiency virus SHIV-vpu+ by triple and quadruple combinations of human monoclonal antibodies and high-titer anti-human immunodeficiency virus type 1 immunoglobulins.: J Virol. 1998 Apr;72(4):3235-40. Unique Identifier : AIDSLINE MED/98184563; Li A; Katinger H; Posner MR; Cavacini L; Zolla-Pazner S; Gorny MK; Sodroski J; Chou TC; Baba TW; Ruprecht RM; Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute, and; Harvard Medical School, Boston, Massachusetts 02115, USA.; We have tested triple and quadruple combinations of human monoclonal antibodies (MAbs), which are directed against various epitopes on human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins, and a high-titer anti-HIV-1 human immunoglobulin HIVIG) preparation for their abilities to neutralize a chimeric sim
In vivo replication capacity rather than in vitro macrophage tropism predicts efficiency of vaginal transmission of simian immunodeficiency virus or simian/human immunodeficiency virus in rhesus macaques.: J Virol. 1998 Apr;72(4):3248-58. Unique Identifier : AIDSLINE MED/98184565; Miller CJ; Marthas M; Greenier J; Lu D; Dailey PJ; Lu Y; California Regional Primate Research Center, and Department of; Veterinary Pathology, Microbiology and Immunology, School of; Veterinary Medicine, University of California Davis, 95616, USA.; cjmiller@ucdavis.edu; We used the rhesus macaque model of heterosexual human immunodeficiency virus (HIV) transmission to test the hypothesis that in vitro measures of macrophage tropism predict the ability of a primate lentivirus to initiate a systemic infection after intravaginal inoculation. A single atraumatic intravaginal inoculation
Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo.: J Virol. 1998 Apr;72(4):3300-6. Unique Identifier : AIDSLINE MED/98184570; Zennou V; Mammano F; Paulous S; Mathez D; Clavel F; Unite d'Oncologie Virale, Departement Sida et Retrovirus, Institut; Pasteur, Paris, France.; We examined the viral replicative capacity and protease-mediated processing of Gag and Gag-Pol precursors of human immunodeficiency virus (HIV) variants selected for resistance to protease inhibitors . We compared recombinant viruses carrying plasma HIV RNA protease
Human immunodeficiency virus neurotropism: an analysis of viral replication and cytopathicity for divergent strains in monocytes and microglia.: J Virol. 1998 Apr;72(4):3340-50. Unique Identifier : AIDSLINE MED/98184574; Ghorpade A; Nukuna A; Che M; Haggerty S; Persidsky Y; Carter E; Carhart L; Shafer L; Gendelman HE; Center for Neurovirology and Neurodegenerative Disorders and the; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68198, USA.; Productive replication of human immunodeficiency virus type 1 HIV-1) in brain macrophages and microglia is a critical component of viral neuropathogenesis. However, how virus-macrophage interactions lead to neurological disease remains incompletely understood. Possibly, a differential ability of virus to replicate in
Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia.: J Virol. 1998 Apr;72(4):3351-61. Unique Identifier : AIDSLINE MED/98184575; Ghorpade A; Xia MQ; Hyman BT; Persidsky Y; Nukuna A; Bock P; Che M; Limoges J; Gendelman HE; Mackay CR; Center for Neurovirology and Neurodegenerative Disorders and; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68198, USA.; Human immunodeficiency virus type 1 (HIV-1) infection in mononuclear phagocyte lineage cells (monocytes, macrophages, and microglia) is a critical component in the pathogenesis of viral infection. Viral replication in macrophages serves as a reservoir, a site of dissemination, and an instigator for neurological sequel
Efficient expression and rapid purification of human T-cell leukemia virus type 1 protease.: J Virol. 1998 Apr;72(4):3383-6. Unique Identifier : AIDSLINE MED/98184579; Ding YS; Owen SM; Lal RB; Ikeda RA; School of Chemistry and Biochemistry, Georgia Institute of Technology,; Atlanta 30332-0400, USA.