1998

Access to dental care: changes over time for HIV+/AIDS patients.: Northwest Dent Res. 1997 Spring;7(2):28-30. Unique Identifier : AIDSLINE MED/98148889; Guistino V; Ayer WA; Wilson CJ
T-Cell repertoire in the blood and lungs of atopic asthmatics before and after ragweed challenge.: Am J Respir Cell Mol Biol. 1998 Mar;18(3):370-83. Unique Identifier : AIDSLINE MED/98158673; Yurovsky VV; Weersink EJ; Meltzer SS; Moore WC; Postma DS; Bleecker ER; White B; Department of Medicine, University of Maryland, Baltimore, Maryland; 21201, USA. vyurovsk@umabnet.ab.umd.edu; T cells play a pivotal role in initiating and orchestrating allergic responses in asthma. The goal of this work was to learn whether ragweed challenge in the lungs alters the T-cell repertoire expressed in the blood and lungs of atopic asthmatics. Analyses of cell numbers, differentials, and T-cell subsets in bronchoa
Analysis of the interaction of antibodies with a conserved enzymatically deglycosylated core of the HIV type 1 envelope glycoprotein 120.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):191-8. Unique Identifier : AIDSLINE MED/98150872; Binley JM; Wyatt R; Desjardins E; Kwong PD; Hendrickson W; Moore JP; Sodroski J; Aaron Diamond AIDS Research Center, The Rockefeller University, New; York, New York 10016, USA.; The binding of a panel of monoclonal antibodies to V1, V2, and V3 loop-deleted HIV-1 gp120 was studied by competition analysis. Most of the previously defined relationships between gp120 epitopes were preserved on the variable loop-deleted protein, although interactions between some epitopes were dependent on the pres
Effect of enzymatic deglycosylation on feline immunodeficiency virus sensitivity to antibody-mediated neutralization.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):199-204. Unique Identifier : AIDSLINE MED/98150873; Giannecchini S; Matteucci D; Bendinelli M; Retrovirus Center and Virology Section, Department of Biomedicine,; University of Pisa, Italy.; We have investigated the effect of deglycosylation with peptide-N-glycosidase F (PNGase F) on the sensitivity to inhibition by immune sera of two variants of the Petaluma strain of feline immunodeficiency virus (FIV-Pet), one sensitive to antibody-mediated neutralization because tissue culture adapted and the other, o
Involvement of the complement system in antibody-mediated post-exposure protection against human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):205-11. Unique Identifier : AIDSLINE MED/98150874; Gauduin MC; Weir R; Fung MS; Koup RA; The Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1LAI confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the involvement of the complement system in protection were evaluated in
A human monoclonal antibody specific for the V3 loop of HIV type 1 clade E cross-reacts with other HIV type 1 clades.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):213-21. Unique Identifier : AIDSLINE MED/98150875; Gorny MK; Mascola JR; Israel ZR; VanCott TC; Williams C; Balfe P; Hioe C; Brodine S; Burda S; Zolla-Pazner S; New York University Medical Center, New York 10016, USA.; To ascertain the antigenic relationship between HIV-1 viruses belonging to various genetically defined subgroups (clades), shared epitopes need to be defined. Human monoclonal antibodies MAbs) are particularly useful for this purpose because they can detect complex regions of viral proteins that may be missed by seque
The potential roles of 4-1BB costimulation in HIV type 1 infection.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):223-31. Unique Identifier : AIDSLINE MED/98150876; Wang S; Kim YJ; Bick C; Kim SH; Kwon BS; Department of Microbiology and Immunology, Walther Oncology Center,; Indiana University School of Medicine, Indianapolis 46202, USA.; The potential role of 4-1BB in human immunodeficiency virus HIV-1)-infected T cells was investigated with HIV-1-infected subjects. 4-1BB expression was readily inducible on PHA stimulation of T cells from HIV-1-infected individuals. The level of 4-1BB expression and the percentage of 4-1BB-expressing T cells were high
Inhibition of HIV type 1 BaL replication by MIP-1alpha, MIP-1beta, and RANTES in macrophages.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):233-40. Unique Identifier : AIDSLINE MED/98150877; Capobianchi MR; Abbate I; Antonelli G; Turriziani O; Dolei A; Dianzani F; Institute of Virology, University La Sapienza, Rome, Italy.; The beta-chemokines RANTES, MIP-1alpha, and MIP-1beta have been shown to inhibit the infection of T cells by macrophage-tropic HIV-1 strains by blocking env-driven HIV-1 fusion through competition for the chemokine receptors or receptor downregulation. This study was aimed at testing whether beta-chemokines also inhib
Nonsynonymous mutations within the human immunodeficiency virus type 1 p17 gene are clustered to sequences binding to the host human leukocyte antigen class I molecules.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):241-8. Unique Identifier : AIDSLINE MED/98150878; Birk M; Vahlne A; Sonnerborg A; Sallberg M; Division of Clinical Virology, Huddinge University Hospital, Sweden.; We have analyzed the relation between intrapatient variabilities of the p17 gene and the location of known host p17 cytotoxic T lymphocyte (CTL) epitopes in five patients infected with human immunodeficiency virus type 1 (HIV-1). All patients were typed with respect to the human leukocyte antigen (HLA) class I type. O
Lamivudine resistance of HIV type 1 does not delay development of resistance to nonnucleoside HIV type 1-specific reverse transcriptase inhibitors as compared with wild-type HIV type 1.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):249-53. Unique Identifier : AIDSLINE MED/98150879; Jonckheere H; Witvrouw M; De Clercq E; Anne J; Rega Institute for Medical Research, Leuven, Belgium.; We compared the development of resistance toward BI-RG-587 nevirapine ) and alpha-APA R89439 (loviride) starting from the wild-type HIV-1 strain IIIB and the 3TC-resistant HIV-1 strain containing the M184V mutation. The reverse transcriptase of the M18
A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):255-60. Unique Identifier : AIDSLINE MED/98150880; Balzarini J; Pelemans H; Esnouf R; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium. Jan.Balzarini@rega.kuleuven.ac.be; Treatment of wild-type human immunodeficiency virus [HIV-1(IIIB)]-infected cell cultures with the thiocarboxanilide UC-781 under low selective pressure (i.e., 0.01 microg/ml) resulted in the emergence of V106A RT mutant virus. On increasing drug concentrations (stepwise up to 30 microg/ml) the virus retained the V106A
Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):261-7. Unique Identifier : AIDSLINE MED/98150881; Arai M; Kannagi M; Matsuoka M; Sato T; Yamamoto N; Fujii M; Department of Immunotherapeutics, Medical Research Division, Tokyo; Medical and Dental University, Yushima, Japan.; Human T cell leukemia virus type 1 (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with an autoimmune condition. We examined the sensitivity of HTLV-I-infected T cell lines to Fas-mediated apoptosis, which plays a critical role in the elimination of self-reactive
Severe combined immunodeficient mice engrafted with macaque peripheral blood leukocytes support replication of SIVsmm.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):269-74. Unique Identifier : AIDSLINE MED/98150882; Schwiebert RS; Fultz PN; Department of Microbiology, University of Alabama School of Medicine,; Birmingham 35294, USA.; Peripheral blood leukocytes (PBLs) from normal pigtail macaques were engrafted into severe combined immunodeficient C.B-17 scid/scid (SCID) mice to develop a small animal model in which to study and identify genetic determinants responsible for the acutely lethal disease syndrome induced by SIVsmmPBj14 SIV-PBj14) in p
Partial protection by vaccination with recombinant feline immunodeficiency virus surface glycoproteins.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):275-83. Unique Identifier : AIDSLINE MED/98150883; Leutenegger CM; Hofmann-Lehmann R; Holznagel E; Cuisinier AM; Wolfensberger C; Duquesne V; Cronier J; Allenspach K; Aubert A; Ossent P; Lutz H; Clinical Laboratory, Department of Internal Veterinary Medicine,; University of Zurich, Switzerland. christi8@vetklinik.unizh.ch; In an effort to induce a strong immune response that might protect against feline immunodeficiency virus (FIV) challenge infection, three groups of five specified pathogen-free (spf) cats each were immunized subcutaneously with different FIV antigen preparations. Immunizations were done at weeks 0, 2, and 4 with 100 m
Cloning and characterization of a virtually full-length HIV type 1 genome from a subtype B'-Thai strain representing the most prevalent B-clade isolate in China.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):285-8. Unique Identifier : AIDSLINE MED/98150884; Graf M; Shao Y; Zhao Q; Seidl T; Kostler J; Wolf H; Wagner R; Institute of Medical Microbiology, University of Regensburg, Germany.
Full-length sequence of human immunodeficiency virus type 1 subtype A, recombined with subtype C in the env V3 domain.: AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):289-92. Unique Identifier : AIDSLINE MED/98150885; Sherefa K; Johansson B; Salminen M; Sonnerborg A; Division of Clinical Virology, Karolinska Institute, Huddinge; University Hospital, Stockholm, Sweden.
Species-dependent enantioselective pharmacokinetics of PNU-103017, a pyrone HIV protease inhibitor.: Chirality. 1998;10(3):210-6. Unique Identifier : AIDSLINE MED/98160547; Zhong WZ; Williams MG; Borin MT; Padbury GE; Pharmacia & Upjohn, Kalamazoo, MI 49001, USA. wzhong@am.pnu.com; PNU-103017, 4-Cyano-N-(3-(cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy- 2-oxo-2H-cycloocta(b) pyran-3-yl)methyl)phenyl)-benzenesulfonamide, is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immunodeficiency Diseases. PNU-103017 is a racemic mixture of two enantio
[Care of children with HIV infection]: Kinderkrankenschwester. 1997 Dec;16(12):516-8. Unique Identifier : AIDSLINE MED/98131454; Czudzewitz U; Bennauer M; Hohendahl J; Nageler-Kokott H; Backes E; Grosse S; Klinik fur Kinder- und Jugendmedizin, Ruhr-Universitat Bochum.
Management of adult T-cell leukaemia/lymphoma.: Br J Haematol. 1998 Mar;100(3):453-8. Unique Identifier : AIDSLINE MED/98163153; Pawson R; Mufti GJ; Pagliuca A; Department of Haematology, Royal Free Hospital, London.
CD8+/CD57 cells and apoptosis suppress T-cell functions in multiple myeloma.: Br J Haematol. 1998 Mar;100(3):469-77. Unique Identifier : AIDSLINE MED/98163156; Frassanito MA; Silvestris F; Cafforio P; Dammacco F; Department of Biomedical Sciences and Human Oncology, University of; Bari, Medical School, Italy.; The aim of this study was to evaluate the role of CD8+/CD57+ lymphocytes in the immune dysregulation of multiple myeloma (MM). Cytofluorimetry of peripheral blood lymphocytes (PBL) purified from 39 MM patients showed an inverse relationship between the percentage of CD8+/CD57+ cells and CD4/CD8 ratio. Analysis of thei
Deleted HTLV provirus in peripheral blood cells of a patient with T-cell prolymphocytic leukaemia.: Br J Haematol. 1998 Mar;100(3):567-70. Unique Identifier : AIDSLINE MED/98163170; Kojima K; Sawada T; Yasukawa M; Matsuo Y; Yakushijin Y; Narumi H; Azuma T; Takimoto H; Hara M; Division of Haematology, Ehime Prefectural Central Hospital, Japan.; We describe the first case of T-cell prolymphocytic leukaemia T-PLL) in which the peripheral blood cells contained a human T-lymphotropic virus (HTLV) related tax sequence. Serum screening tests for anti-HTLV-I/II antibodies were negative. Polymerase chain reaction disclosed the presence of an HTLV-I tax sequence in t
The platelet and endothelium in HIV infection [letter]: Br J Haematol. 1998 Mar;100(3):613-4. Unique Identifier : AIDSLINE MED/98163186; Blann A; Constans J; Dignat-George F; Seigneur M
[Species identification of intestinal microsporidiosis in HIV-positive patients using the polymerase chain reaction]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):456-61. Unique Identifier : AIDSLINE MED/98096939; del Aguila C; Soriano V; Navajas R; Subirats M; Fenoy S; Valencia E; Baquero M; Pieniazek NJ; Seccion de Parasitologia, Facultad de Ciencias Experimentales y; Tecnicas, Universidad San Pablo-CEU, Madrid.; BACKGROUND: Microsporidia are opportunistic parasites which, due to their morphologic characteristics, continue presenting diagnostic problems. Species-specific identification of microsporidia has become important because of varying levels of response to albendazole, which is the only effective treatment for some kind
[Patients with human immunodeficiency virus admitted to the emergency service of a general hospital]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):468-72. Unique Identifier : AIDSLINE MED/98096941; Iglesias ML; Pedro-Botet J; Hernandez E; Villalta R; Alvarez A; Gutierrez J; Skaf E; Servicio de Urgencias, Hospital del Mar, Universidad Autonoma de; Barcelona.; BACKGROUND: The description of the demographic, toxicologic, immunologic and clinicopathologic characteristics of patients with known human immunodeficiency virus infection (HIV) admitted to hospital through the emergency department is presented. METHODS: A cohort study of patients with known HIV seropositivity who co
[Diarrhea caused by Cryptosporidium as the initial manifestation of AIDS in an elderly man (letter)]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):495-6. Unique Identifier : AIDSLINE MED/98096948; Velasco M; Pintor E; Piret MV; Barreiro P; Ruiz M; Hernandez MJ
[Persistent bacteremia and infection of an intravascular device by Agrobacterium radiobacter (tumefaciens) in a boy with AIDS letter)]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):496-7. Unique Identifier : AIDSLINE MED/98096949; Salavert M; Breton JR; Perez-Tamarit D; Perez-Belles C; Gobernado M
[Tuberculous abscess simulating complicated acute appendicitis in a patient with HIV infection (letter)]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):497-8. Unique Identifier : AIDSLINE MED/98096950; Pintor E; Velasco M; Piret MV; Minguez P; Ruiz M
[Epiglottitis caused by Haemophilus influenzae type b in a patient with AIDS (letter)]: Enferm Infecc Microbiol Clin. 1997 Nov;15(9):499-500. Unique Identifier : AIDSLINE MED/98096952; Moro MJ; Gutierrez J; Gorgolas M
Differential modulation of the immune response by breast- or formula-feeding of infants.: Acta Paediatr. 1997 Dec;86(12):1291-7. Unique Identifier : AIDSLINE MED/98133450; Pabst HF; Spady DW; Pilarski LM; Carson MM; Beeler JA; Krezolek MP; Department of Pediatrics, University of Alberta, Edmonton, Canada.; Spontaneous integrin expression on CD4+, CD8+ and CD19+ lymphocytes at 6 months was significantly lower in breastfed than formula-fed infants (p
Gender differences in care for acquired immunodeficiency syndrome-related Pneumocystis carinii pneumonia.: Womens Health Issues. 1998 Jan-Feb;8(1):45-52. Unique Identifier : AIDSLINE MED/98164789; Bastian LA; Sloane RJ; DeHovitz JA; Bennett CL; Center for Health Services Research in Primary Care, Durham Veteran; Affairs Medical Center, North Carolina, USA.
Familial transmission of human T-lymphotropic virus type 1 HTLV-1) in patients with adult T-cell leukemia/lymphoma or HTLV-1-associated myelopathy.: J Formos Med Assoc. 1998 Feb;97(2):101-5. Unique Identifier : AIDSLINE MED/98170595; Hu CY; Lin MT; Yang YC; Tang JL; Tseng LH; Wang CH; Chen YC; Yang CS; School of Medical Technology, College of Medicine, National Taiwan; University, Taipei, Taiwan.; The seroprevalence of human T-lymphotropic virus type 1 (HTLV-1) in Taiwan is 0.48%. In this study, we investigated the patterns of intrafamilial transmission of HTLV-1 in Taiwanese patients with adult T-cell leukemia/lymphoma (ATL/
Recombinant coagulation factors.: Blood Rev. 1997 Dec;11(4):169-77. Unique Identifier : AIDSLINE MED/98142446; Roddie PH; Ludlam CA; Department of Haematology, Royal Infirmary of Edinburgh, UK.; The advent of technology that has allowed production of recombinant proteins on an industrial scale has revolutionized haemophilia care. Recombinant coagulation factors, as opposed to their plasma-derived counterparts, have a very low risk for transmission of infectious agents and their use should eradicate the threat
The prevalence of Enterocytozoon bieneusi in acquired immunodeficiency syndrome (AIDS) patients from the north west of England: 1992-1995.: Br J Biomed Sci. 1997 Sep;54(3):186-91. Unique Identifier : AIDSLINE MED/98160571; Kyaw T; Curry A; Edwards-Jones V; Craske J; Mandal BK; Public Health Laboratory, Withington Hospital, Manchester, England,; UK.; Microsporidia are increasingly being recognised as important enteric pathogens in patients with advanced human immunodeficiency virus (HIV) disease, i.e. acquired immunodeficiency syndrome (AIDS). The aims of this study were to investigate the frequency of detection of microsporidia associated with diarrhoea in patien
Microsporidial infections in humans: current practice and developments in laboratory diagnosis.: Br J Biomed Sci. 1997 Sep;54(3):216-21. Unique Identifier : AIDSLINE MED/98160574; Windsor JJ; Department of Microbiology and Immunology, College of Medicine, Sultan; Qaboos University, Muscat, Sultanate of Oman.; Microsporidia are small, intracellular parasites that infect a wide range of hosts, including vertebrates, invertebrates and fish. They were discovered more than a century ago. The first well documented human case, however, was not reported until 100 years later. Since the first case of intestinal
Differences by ancestry in sociodemographics and risk behaviors among Latinos with AIDS. The Supplement to HIV and AIDS Surveillance Project Group.: Ethn Dis. 1997 Autumn;7(3):200-6. Unique Identifier : AIDSLINE MED/98128883; Diaz T; Klevens M; Centers for Disease Control and Prevention, Division of HIV and AIDS; Prevention, Atlanta, GA 30333, USA.; To describe differences by ancestry, we interviewed 1,785 self-identified Latinos who have been reported to have acquired immunodeficiency syndrome from 12 state or local health departments. Central American men and women were the least acculturated group: > 90% were born outside the USA, and more than half answered t
The patient showing HIV infection [news]: Natl Med J India. 1997 Nov-Dec;10(6):298-9. Unique Identifier : AIDSLINE MED/98142104; Pandya SK
[Pilot study of the characteristics of transfused patients and utilized labile blood products]: Transfus Clin Biol. 1997 Dec;4(6):533-40. Unique Identifier : AIDSLINE MED/98108958; Mathoulin-Pelissier S; Vicariot M; Gross S; Waller C; Courtois F; Eghbali H; Saves M; Verret C; Salmi LR; Centre national d'hemovigilance, Bordeaux.; The aim of this study was to describe blood recipients and blood components transfused during the first 24 hours in 13 French hospitals. We included all blood recipients who had not had any blood transfusion within the past six months. Recipients were screened for red cell alloantibodies, the alanine aminotransferase
Tuberculosis in the hospice--a cause for concern?: Palliat Med. 1997 Nov;11(6):469-74. Unique Identifier : AIDSLINE MED/98179694; McKeogh MM; Mildmay Mission Hospital, London, UK.; Open pulmonary tuberculosis has been increasingly seen in HIV-infected patients in this hospice. Multidrug-resistant tuberculosis is a new and serious threat and two cases have occurred in our hospice in the past two years. This infection poses a health risk to staff, patients, relatives and volunteers. Palliative car
AIDS-associated biliary tract disease [letter]: J Am Coll Surg. 1998 Mar;186(3):373-4. Unique Identifier : AIDSLINE MED/98169091; Barie PS
Transplacental antibody transfer and neonatal immunity.: Br J Hosp Med. 1997 Oct 1-14;58(7):317-9. Unique Identifier : AIDSLINE MED/98169785; de Moraes-Pinto I; Hart CA; Department of Medical Microbiology and Genito-Urinary Medicine,; University of Liverpool.
The role of CpG dinucleotides in DNA vaccines.: Trends Microbiol. 1998 Jan;6(1):23-7. Unique Identifier : AIDSLINE MED/98142819; Krieg AM; Yi AK; Schorr J; Davis HL; University of Iowa, Dept of Internal Medicine, Iowa City 52242, USA.; arthur-krieg@uiowa.edu; DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventi
Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans.: QJM. 1998 Jan;91(1):13-8. Unique Identifier : AIDSLINE MED/98179732; Bellamy R; Ruwende C; McAdam KP; Thursz M; Sumiya M; Summerfield J; Gilbert SC; Corrah T; Kwiatkowski D; Whittle HC; Hill AV; Wellcome Trust Centre for Human Genetics, Oxford University, UK.; We retrospectively studied MBP genotypes in patients with malaria, tuberculosis (TB), and persistent hepatitis B virus HBV) carriage, in clinics and hospitals in The Gambia . Children under 10 years with cerebral malaria and/or severe malarial anaemia, were compared with children wi
Treatment of Felty's syndrome with the haemopoietic growth factor granulocyte colony-stimulating factor (G-CSF).: QJM. 1998 Jan;91(1):49-56. Unique Identifier : AIDSLINE MED/98179736; Stanworth SJ; Bhavnani M; Chattopadhya C; Miller H; Swinson DR; Department of Haematology, Manchester Royal Infirmary.; Felty s syndrome (FS) (rheumatoid arthritis with neutropenia and splenomegaly) has a poor prognosis, largely because of the high risk of severe infection. Granulocyte colony-stimulating factor G-CSF) is an emerging treatment for chronic neutropenia. We prospectively monitored its use in eight patients with recurrent i
The 2nd National AIDS Malignancy Conference. Bethesda, Maryland, USA. April 6-8, 1998. Abstracts.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):A1-43. Unique Identifier : AIDSLINE MED/98192040
Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):291-5. Unique Identifier : AIDSLINE MED/98184340; Gisslen M; Hagberg L; Fuchs D; Norkrans G; Svennerholm B; Department of Infectious Diseases, Goteborg University, Sweden.; HIV-1 RNA and neopterin levels were observed longitudinally for 20 to 68 months (mean, 37.5 months) in cerebrospinal fluid (CSF) and serum in 15 HIV-1-infected patients not receiving antiretroviral treatment. During the course of infection the HIV-1 RNA levels increased significantly in CSF, from a mean of 3.08 to 3.5
Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):296-302. Unique Identifier : AIDSLINE MED/98184341; Balzarini J; Cahard D; Wedgwood O; Salgado A; Velazquez S; Yarnold CJ; De Clercq E; McGuigan C; Thormar H; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; Lipophilic masked aryloxyaminoacylphosphoramidate derivatives of 2 ,3 -dideoxynucleoside (ddN) analogues with potent anti-HIV activity (i.e., stavudine [ d4T ], azidothymidine [
Unintegrated circular HIV-1 DNA in the peripheral mononuclear cells of HIV-1-infected subjects: association with high levels of plasma HIV-1 RNA, rapid decline in CD4 count, and clinical progression to AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):303-13. Unique Identifier : AIDSLINE MED/98184342; Panther LA; Coombs RW; Zeh JE; Collier AC; Corey L; Department of Medicine, University of Washington, Seattle, USA.; We observed 36 HIV-infected patients to evaluate whether the presence of tandem 2-long terminal repeat circular unintegrated HIV-1 DNA (2-LTR) in peripheral blood mononuclear cells (PBMC) at baseline was associated with acceleration of HIV disease. Detection of 2-LTR at baseline correlated with high plasma HIV-1 RNA l
Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):314-9. Unique Identifier : AIDSLINE MED/98184343; Palefsky JM; Holly EA; Hogeboom CJ; Ralston ML; DaCosta MM; Botts R; Berry JM; Jay N; Darragh TM; Department of Laboratory Medicine, University of California-San; Francisco 94143, USA.; Anal cancer may be preceded by anal squamous intraepithelial lesions (ASIL), but the natural history of ASIL is poorly understood. In this report, we characterize the 2-year incidence and progression of low-grade SIL (LSIL) and high-grade SIL (HSIL) in a cohort study in 346 HIV-positive and 262 HIV-negative homosexual
Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):320-6. Unique Identifier : AIDSLINE MED/98184344; Palefsky JM; Holly EA; Ralston ML; Arthur SP; Jay N; Berry JM; DaCosta MM; Botts R; Darragh TM; Department of Laboratory Medicine, University of California-San; Francisco, 94143, USA.; Anal cancer is more commonly found in homosexual and bisexual men than cervical cancer is in women. Invasive anal cancer may be preceded by anal squamous intraepithelial lesions (ASIL), and treatment of ASIL may prevent the development of anal cancer. We characterized the prevalence and risk factors for ASIL in 346 HI
Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):327-31. Unique Identifier : AIDSLINE MED/98184345; Stafford MK; Ward H; Flanagan A; Rosenstein IJ; Taylor-Robinson D; Smith JR; Weber J; Kitchen VS; Department of Genitourinary Medicine and Communicable Diseases,; Chelsea and Westminster Hospital, England.; Nonoxynol-9 (N-9) is virucidal in vitro, and is therefore a candidate microbicide for preventing sexual transmission of HIV. However, the activity of N-9 is nonspecific, suggesting that virucidal levels may produce adverse effects including epithelial disruption, inflammation of the genital mucosa, or both. A randomiz
Laboratory test differences associated with HTLV-I and HTLV-II infection. Retrovirus Epidemiology Donor Study Investigators.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):332-8. Unique Identifier : AIDSLINE MED/98184346; Murphy EL; Glynn S; Watanabe K; Fridey J; Smith J; Sacher R; Wright D; Schreiber G; Luban N; University of California San Francisco 94143-0884, USA.; murphy@labmed.ucsf.edu; Reports of laboratory abnormalities associated with HTLV-I and HTLV-II infection are inconsistent. We assessed complete blood counts and selected serum chemistry measures at enrollment in a cohort of 153 HTLV-I-seropositive, 386 HTLV-II-seropositive, and 795 HTLV-seronegative blood donors. Linear and logistic regressi
Randomized, controlled study of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):339-44. Unique Identifier : AIDSLINE MED/98184347; Lalezari JP; Holland GN; Kramer F; McKinley GF; Kemper CA; Ives DV; Nelson R; Hardy WD; Kuppermann BD; Northfelt DW; Youle M; Johnson M; Lewis RA; Weinberg DV; Simon GL; Wolitz RA; Ruby AE; Stagg RJ; Jaffe HS; University of California, San Francisco-Mt. Zion Medical Center, USA.; To assess the effect of intravenous cidofovir on delaying progression of previously treated, relapsing cytomegalovirus CMV ) retinitis, we conducted a randomized, controlled comparison of two maintenance dose levels of cidofov
Size and duration of zidovudine benefit in 1003 HIV-infected patients: U.S. Army, Navy, and Air Force natural history data. Military Medical Consortium for Applied Retroviral Research.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):345-53. Unique Identifier : AIDSLINE MED/98184348; Gardner LI; Harrison SH; Hendrix CW; Blatt SP; Wagner KF; Chung RC; Harris RW; Cohn DL; Burke DS; Mayers DL; Division of Preventive Medicine, Walter Reed Army Institute of; Research, Washington, DC, USA.; OBJECTIVES: The study s objectives were to determine the size and duration of benefits of early versus delayed versus late treatment with zidovudine (ZDV) on disease progression and mortality in HIV-infected patients, and whether patients rapidly progressing before ZDV treatment had a different outcome from those not
Evaluating the cost of medications for ambulatory HIV-infected persons in association with landmark changes in antiretroviral therapy.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):354-60. Unique Identifier : AIDSLINE MED/98184349; Perdue BE; Weidle PJ; Everson-Mays RE; Bozek PS; Department of Pharmacy Services, University of Maryland Medical; System, Baltimore, USA.; Costs of medications for ambulatory HIV-infected people increase as knowledge of antiretroviral therapy and therapy for opportunistic infection grows. We evaluated the evolution of drug costs for HIV-infected persons who attend a university clinic in Baltimore, Maryland. Cross-sectional abstracts of a cohort of patien
Interpretation of indeterminate HIV serology results in an incarcerated population.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):376-9. Unique Identifier : AIDSLINE MED/98184352; Rich JD; Dickinson BP; Spaulding A; Lafazia L; Flanigan TP; The Miriam Hospital and Brown University, Providence, Rhode Island; 02906, USA.; The objective of this study was to evaluate the significance of indeterminate HIV test results in the prison setting. No specific information or guidelines are currently available to direct counseling of incarcerated persons with an indeterminate HIV test. A medical chart review was conducted on all incarcerated inmat
Prevalence of HTLV-I in leprosy patients in two sanatoriums in Japan.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):380-3. Unique Identifier : AIDSLINE MED/98184353; Muneishi H; Taguchi H; Sawada T; Ikezoe T; Matsui S; Tanaka S; Taniguchi T; Onoue O; Miyoshi I; Department of Internal Medicine, Kochi Medical School, Japan.; To determine the association between leprosy and HTLV-I, 450 and 394 leprosy patients in two sanatoriums in Japan (Sanatorium-A in Okayama prefecture and Sanatorium-B in Gunma prefecture) were investigated serologically for antibodies to HTLV-I. Serology was positive for HTLV-I in 3
Occupational blood exposure and HIV infection among oral and maxillofacial surgeons.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Feb;85(2):128-34. Unique Identifier : AIDSLINE MED/98164185; Gooch BF; Siew C; Cleveland JL; Gruninger SE; Lockwood SA; Joy ED; Centers for Disease Control and Prevention, Atlanta, Ga., USA.; OBJECTIVE: The purpose of this study was to examine occupational blood exposure and the seroprevalence of HIV infection among oral and maxillofacial surgeons. STUDY DESIGN: Three hundred twenty-one oral and maxillofacial surgeons attending an annual meeting voluntarily and anonymously participated in an HIV serosurvey
Comparison of neutralizing and hemagglutination-inhibiting antibody responses to influenza A virus vaccination of human immunodeficiency virus-infected individuals.: Clin Diagn Lab Immunol. 1998 Jan;5(1):114-7. Unique Identifier : AIDSLINE MED/98115426; Benne CA; Kroon FP; Harmsen M; Tavares L; Kraaijeveld CA; De Jong JC; Eijkman-Winkler Laboratory of Medical Microbiology, University; Hospital Utrecht, The Netherlands.; A neutralization enzyme immunoassay (N-EIA) was used to determine the neutralizing serum antibody titers to influenza A/ Taiwan /1/86 H1N1) and Beijing/353/89 (H3N2) viruses after vaccination of 51 human immunodeficiency virus (HIV) t
Distribution of CCR5delta32 in human immunodeficiency virus-infected children and its relationship to disease course.: Clin Diagn Lab Immunol. 1998 Jan;5(1):38-40. Unique Identifier : AIDSLINE MED/98115412; Bakshi SS; Zhang L; Ho D; Than S; Pahwa SG; Department of Pediatrics, North Shore University Hospital-New York; University School of Medicine, Manhasset, USA.; Homozygosity for a 32-bp deletion in the CCR5 gene (CCR5delta32) has been shown to confer resistance to infection with the macrophage-tropic strain of human immunodeficiency virus (HIV) type 1. We examined the distribution of CCR5delta32 in 47 children (age range, 1.5 to 19 years), of whom 43 were infected with HIV, b
Depressed phagocytosis and oxidative burst in polymorphonuclear leukocytes from individuals with pulmonary tuberculosis with or without human immunodeficiency virus type 1 infection.: Clin Diagn Lab Immunol. 1998 Jan;5(1):41-4. Unique Identifier : AIDSLINE MED/98115413; Shalekoff S; Tiemessen CT; Gray CM; Martin DJ; National Institute for Virology, and Department of Virology,; University of the Witwatersrand, Johannesburg, South Africa.; SharonS@niv.ac.za; Phagocytosis and oxidative burst in whole-blood granulocytes were assessed by flow cytometry with Phagotest and Bursttest kits, respectively. Seventy individuals were included in this study: 15 healthy, normal donors, 18 human immunodeficiency virus (HIV) type 1 (HIV-1)-seropositive patients, 19 patients with pulmonar
Assessment of a new immunoassay for serological confirmation and discrimination of human T-cell lymphotropic virus infections.: Clin Diagn Lab Immunol. 1998 Jan;5(1):45-9. Unique Identifier : AIDSLINE MED/98115414; Zrein M; Louwagie J; Boeykens H; Govers L; Hendrickx G; Bosman F; Sablon E; Demarquilly C; Boniface M; Saman E; Innogenetics NV, Ghent, Belgium. maanzre@innogenetics.be; The present study evaluated a new confirmatory assay for antibodies to human T-cell lymphotropic virus type 1 and 2 HTLV-1 and HTLV-2) proteins performed with serum samples from various commercial sources. The new test is a line immunoassay LIA) with a nylon membrane sensitized with the most relevant antigens of HTLVs
HEp-2 cell-adherent Escherichia coli and intestinal secretory immune response to human immunodeficiency virus (HIV) in outpatients with HIV-associated diarrhea.: Clin Diagn Lab Immunol. 1998 Jan;5(1):87-90. Unique Identifier : AIDSLINE MED/98115422; Mathewson JJ; Salameh BM; DuPont HL; Jiang ZD; Nelson AC; Arduino R; Smith MA; Masozera N; Center for Infectious Diseases, The University of Texas School of; Public Health and Medical School, Houston 77030, USA.; JMATHEWSON@UTSPH.SPH.UTH.TMC.EDU; HEp-2 cell-adherent Escherichia coli and the human immunodeficiency virus (HIV) itself have recently been incriminated as causes of chronic HIV-associated diarrhea. This study sought to determine the prevalence of these two agents among HIV-infected patients with diarrhea in an outpatient setting in the
Enhancement of antibody-dependent cellular cytotoxicity of neonatal cells by interleukin-2 (IL-2) and IL-12.: Clin Diagn Lab Immunol. 1998 Jan;5(1):98-104. Unique Identifier : AIDSLINE MED/98115424; Nguyen QH; Roberts RL; Ank BJ; Lin SJ; Lau CK; Stiehm ER; Department of Pediatrics, Children's Hospital, University of; California at Los Angeles, 90095, USA.; Newborn infants are more susceptible to infections due in part to deficiencies in the cytotoxic functions of their lymphocytes. We investigated the ability of interleukin-2 ( IL-2 ) and IL-12 to enhance the cytotoxicity of neonatal (cord blood) and adult mononuclear cell
CCR2 polymorphism and HIV disease. Swiss HIV Cohort [letter]: Nat Med. 1998 Mar;4(3):252-3. Unique Identifier : AIDSLINE MED/98160216; Rizzardi GP; Morawetz RA; Vicenzi E; Ghezzi S; Poli G; Lazzarin A; Pantaleo G
Cancelled trial exposes Japanese research deficiencies [news]: Nat Med. 1998 Mar;4(3):260. Unique Identifier : AIDSLINE MED/98160223; Saegusa A
Chemokine genes--beating the odds [news; comment]: Nat Med. 1998 Mar;4(3):275-7. Unique Identifier : AIDSLINE MED/98160233; Stewart G
Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection: implications for antiviral therapy.: Nat Med. 1998 Mar;4(3):341-5. Unique Identifier : AIDSLINE MED/98160246; Pantaleo G; Cohen OJ; Schacker T; Vaccarezza M; Graziosi C; Rizzardi GP; Kahn J; Fox CH; Schnittman SM; Schwartz DH; Corey L; Fauci AS; Laboratory of AIDS Immunopathogenesis, Department of Medicine, Centre; Hospitalier Vadois, Lausanne, Switzerland.; Evolutionary patterns of virus replication and distribution in lymphoid tissue during the early phases of HIV infection have not been delineated. Lymph node (LN) biopsies were excised from patients at different times after the estimated time of primary infection. Within 3 months of the acute viral syndrome, HIV was mo
Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency.: Nat Med. 1998 Mar;4(3):346-9. Unique Identifier : AIDSLINE MED/98160247; Glushakova S; Grivel JC; Fitzgerald W; Sylwester A; Zimmerberg J; Margolis LB; Laboratory of Cellular and Molecular Biophysics, National Institute of; Child Health and Human Development, National Institutes of Health,; Bethesda, Maryland 20892-1855, USA.; Both cellular and humoral immunodeficiency develop in vivo after prolonged infection with HIV-1, but the mechanisms are unclear. Initial infection with HIV-1 is transmitted by macrophage M)-tropic/non-syncytia-inducing (NSI) viruses, which hyperactivate the immune system, and, in one view, cause immunodeficiency by e
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation [see comments]: Nat Med. 1998 Mar;4(3):350-3. Unique Identifier : AIDSLINE MED/98160248; Kostrikis LG; Huang Y; Moore JP; Wolinsky SM; Zhang L; Guo Y; Deutsch L; Phair J; Neumann AU; Ho DD; The Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.; Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, respectively. Most new infections involve transmission of R5 viruses, but variants can arise la
Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors.: Nat Med. 1998 Mar;4(3):354-7. Unique Identifier : AIDSLINE MED/98160249; Poeschla EM; Wong-Staal F; Looney DJ; Department of Medicine, University of California San Diego, La Jolla; 92093-0655, USA.; The molecular bases for species barriers to lentiviral replication are not well understood, but are of interest for explaining lentiviral pathogenesis, devising therapeutic strategies, and adapting lentiviruses to gene therapy. HIV-1-based lentiviral vectors efficiently transduce nondividing cells, but present complex
Sperm head agglutination induced by V3 peptide does not occur through a CD4 receptor.: Chung Hua I Hsueh Tsa Chih (Taipei). 1998 Jan;61(1):24-8. Unique Identifier : AIDSLINE MED/98170428; Ou MC; Tzeng CR; Ng HT; Department of Obstetrics and Gynecology, Taipei Medical College; Hospital, Taiwan, ROC.; BACKGROUND: Although recent studies have shown that HIV (human immunodeficiency virus) can attach to sperm, the mechanism by which it does this is not yet understood. It has been shown that CD4 receptors on T4 cells are responsible for the binding of gp120 (glycoprotein 120) to HIV; however, the existence of CD4 recep
A fatal case of Rhodotorula meningitis in AIDS.: Med Health R I. 1998 Jan;81(1):22-3. Unique Identifier : AIDSLINE MED/98134206; Ahmed A; Aggarwal M; Chiu R; Ramratnam B; Rinaldi M; Flanigan TP; Division of Gastroenterology, Stanford University School of Medicine,; CA 94305-5487, USA.
Candida dubliniensis: an emerging opportunistic pathogen.: Curr Top Med Mycol. 1997 Dec;8(1-2):15-25. Unique Identifier : AIDSLINE MED/98164814; Sullivan D; Coleman D; Department of Oral Surgery, Oral Medicine and Oral Pathology, School; of Dental Science, University of Dublin, Trinity College, Ireland.; djsullvn@tcd.ie; The incidence of opportunistic fungal infections continues to increase, partly as a result of the continuing AIDS epidemic. Candida albicans remains the most important fungal pathogen and is frequently associated with oral candidiasis in HIV-infected individuals. Over the past decade, however, there has been an increa
Penicillium marneffei infection in patients infected with human immunodeficiency virus.: Curr Top Med Mycol. 1997 Dec;8(1-2):35-42. Unique Identifier : AIDSLINE MED/98164816; Vanittanakom N; Sirisanthana T; Faculty of Medicine, Chiang Mai University, Thailand.; Opportunistic infections are major causes of morbidity in patients with human immunodeficiency virus (HIV) infection. Penicillium marneffei infection is very common in HIV-infected individuals in northern Thailand . The patients usually present with fever, anemia, weight loss, ski
High-performance liquid chromatographic determination of ritonavir in human plasma, cerebrospinal fluid and saliva.: J Chromatogr B Biomed Sci Appl. 1998 Jan 23;705(1):119-26. Unique Identifier : AIDSLINE MED/98158443; Hoetelmans RM; van Essenberg M; Profijt M; Meenhorst PL; Mulder JW; Beijnen JH; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; A simple, ion-pair high-performance liquid chromatographic method has been developed and validated for the quantitative determination of the HIV protease inhibitor ritonavir in human plasma, cerebrospinal fluid and saliva. Sample pretreatment consiste
The UL6 locus of pseudorabies virus and its homology to oncogenic herpesviruses.: Oncol Rep. 1998 Jan-Feb;5(1):115-9. Unique Identifier : AIDSLINE MED/98124637; Pederson NE; Casey JT 2nd; Koslowski KM; Shaver PR; Department of Microbiology and Immunology, East Carolina University; School of Medicine, Greenville, NC, 27858-4354, USA.; The UL6 locus of pseudorabies virus (PRV) was analyzed to reveal a gene cluster with homology to herpes simplex virus UL5, UL6, UL7 and UL8, Epstein-Barr virus BBRF1 and BBRF2, and Kaposi sarcoma-associated herpes virus ORF43 and ORF42. The noncoding region between PRV UL7 and UL8 contained 16 copies of a 14 bp T + C-
Functionally and phenotypically mature mouse CD8+ T cells develop in porcine thymus grafts in mice.: Xenotransplantation. 1998 Feb;5(1):99-104. Unique Identifier : AIDSLINE MED/98168584; Zhao Y; Barth RN; Swenson K; Pearson DA; Sykes M; Bone Marrow Transplantation Section, Massachusetts General; Hospital/Harvard Medical School, Boston 02129, USA.; Mouse CD4+ T cells efficiently develop in fetal pig thymus (FP THY) grafts and repopulate the periphery of T cell and NK cell-depleted, thymectomized (ATX) mice. However, efficient peripheral repopulation of mouse CD8+ T cells does not occur in these mice. We have therefore evaluated the maturation and function of mou
Inhibition of methadone and buprenorphine N-dealkylations by three HIV-1 protease inhibitors.: Drug Metab Dispos. 1998 Mar;26(3):257-60. Unique Identifier : AIDSLINE MED/98160431; Iribarne C; Berthou F; Carlhant D; Dreano Y; Picart D; Lohezic F; Riche C; Laboratoires de Biochimie-Nutrition EA948, Faculte de Medecine, Brest,; France.; Ritonavir , indinavir, and saquinavir, all human immunodeficiency virus-1 protease inhibitors with a potent antiviral effect during triple therapy, are extensively metabolized by liver cytochrome P45
Schizophrenic patients before and after HIV infection: a case-control study.: Encephale. 1997 Nov-Dec;23(6):437-41. Unique Identifier : AIDSLINE MED/98150184; Mauri MC; Fabiano L; Bravin S; Ricci C; Invernizzi G; Department of Clinical Psychiatry, University of Milan, IRCCS,; Ospedale Maggiore di Milano, Italy.; Thirteen HIV positive schizophrenic patients (Group 1), age ranging from 23 to 60 years, diagnosed as schizophrenics (DSM IV), were studied during a four week hospitalization period, due to an acute exacerbation phase. The patients were treated with haloperidol (3-15 mg/die p.o.) and diazepam (2-25 mg/die p.o.). Clini
[Epidemiology of psychopathologic disorders in infectious diseases]: Encephale. 1997 Dec;23 Spec No 5:3-8. Unique Identifier : AIDSLINE MED/98150171; Pelissolo A; Service de Psychiatrie, Hopital Fernand-Widal, Paris.
[Neuropsychiatric complications and HIV infection in the adult]: Encephale. 1997 Dec;23 Spec No 5:30-5. Unique Identifier : AIDSLINE MED/98150176; Bouvet O; Centre Hospitalier Ste-Anne, Paris.
[Psychologic effect of HIV infection. Occasional support by psychoanalytic consultation]: Encephale. 1997 Dec;23 Spec No 5:36-42. Unique Identifier : AIDSLINE MED/98150177; Duval F; Navelet C; Psychologue Clinicien, Hopital Rotschild, Paris.
[Depressive states during severe infectious illnesses]: Encephale. 1997 Dec;23 Spec No 5:9-13. Unique Identifier : AIDSLINE MED/98150172; Salmon D; Mercuel A; Hopital Cochin, Paris.
Selective tolerization of Th1-like cells after nasal administration of a cholera toxoid-LACK conjugate.: Eur J Immunol. 1998 Feb;28(2):424-32. Unique Identifier : AIDSLINE MED/98180344; McSorley SJ; Rask C; Pichot R; Julia V; Czerkinsky C; Glaichenhaus N; Centre National de la Recherche Scientifique, Institut de; Pharmacologie Moleculaire et Cellulaire, Valbonne, France.; mcsor001@tc.umn.edu; Recent reports have suggested that after infection of BALB/c mice with Leishmania major, CD4+ T cells responding to a single antigen, LACK (Leishmania homologue of receptors for activated C kinase), drive the differentiation of other responding T cells to the Th2 phenotype and so allow lesion development to occur. Tra
The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb.: Eur J Immunol. 1998 Feb;28(2):525-31. Unique Identifier : AIDSLINE MED/98180357; Ferlin WG; von der Weid T; Cottrez F; Ferrick DA; Coffman RL; Howard MC; Department of Immunobiology, DNAX Research Institute, Palo Alto, CA,; USA.; A protective immune response to the intracellular parasite Leishmania major requires the development of a Th1 CD4+ T cell phenotype. We demonstrate herein that BALB/c mice, which normally develop a susceptible Th2 response to L. major infection, are protected when co-injected with an agonistic anti-murine CD40 mAb. An
Stable polarization of peripheral blood T cells towards type 1 or type 2 phenotype after polyclonal activation.: Eur J Immunol. 1998 Feb;28(2):532-9. Unique Identifier : AIDSLINE MED/98180358; Asselin S; Conjeaud H; Minty A; Fradelizi D; Breban M; INSERM U477, Hopital Cochin, Universite Rene Descartes, Paris, France.; Polarization of T lymphocytes towards type 1 (T1) or type 2 (T2) subsets producing a distinct array of cytokines plays a role in several diseases and could be used for therapeutic intervention. Bearing this purpose in mind, we have established suitable in vitro conditions to drive resting polyclonal human T cells towa
Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection.: Eur J Immunol. 1998 Feb;28(2):560-9. Unique Identifier : AIDSLINE MED/98180361; Petschner F; Zimmerman C; Strasser A; Grillot D; Nunez G; Pircher H; Institute for Medical Microbiology and Hygiene, Department of; Immunology, University of Freiburg, Germany.; We examined the CD8+ T cell response to lymphocytic choriomeningitis virus (LCMV) in mice doubly transgenic for an LCMV-specific TCR and for either bcl-xL or bcl-2. Clonal down-sizing of the anti-viral CD8+ T cell response and the generation of T cell memory was not influenced by constitutive expression of these anti-
CD40 ligand and IFN-gamma synergistically restore IL-12 production in HIV-infected patients.: Eur J Immunol. 1998 Feb;28(2):646-56. Unique Identifier : AIDSLINE MED/98180370; Chougnet C; Thomas E; Landay AL; Kessler HA; Buchbinder S; Scheer S; Shearer GM; Experimental Immunology Branch, National Cancer Institute, Bethesda,; MD 20892, USA.; IL-12 production in HIV-infected (HIV+) individuals is severely impaired after stimulation by bacterial products or T cell-dependent stimuli. Because CD40-CD40 ligand (CD40L) interactions are the major mechanism involved in the T cell-dependent activation of antigen-presenting cells, we investigated whether this pathw
Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani.: Eur J Immunol. 1998 Feb;28(2):669-80. Unique Identifier : AIDSLINE MED/98180372; Engwerda CR; Murphy ML; Cotterell SE; Smelt SC; Kaye PM; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, GB. c.engwerda@lshtm.ac.uk; IL-12 plays a key role in stimulating both innate and antigen-specific immune responses against a number of intracellular pathogens. A neutralizing anti-IL-12 monoclonal antibody (mAb) was used to define and compare the role of endogenous IL-12 in the liver and spleen of mice infected with Leishmania donovani. IL-12 n
Antigen dose-dependent differences in IgE antibody production are not due to polarization towards Th1 and Th2 cell subsets.: Eur J Immunol. 1998 Feb;28(2):681-6. Unique Identifier : AIDSLINE MED/98180373; Arps V; Sudowe S; Kolsch E; Institute for Immunology, University of Munster, Germany.; arps@uni-muenster.de; The quality of the humoral immune response against protein antigens in CBA/J mice is dependent on the antigen dose used for immunization: low doses induce high titers of IgE antibodies, whereas high doses promote the production of IgG2a antibodies but inhibit IgE formation. To investigate whether the reciprocal regula
A T cell activation antigen, Ly6C, induced on CD4+ Th1 cells mediates an inhibitory signal for secretion of IL-2 and proliferation in peripheral immune responses.: Eur J Immunol. 1998 Feb;28(2):696-707. Unique Identifier : AIDSLINE MED/98180375; Yamanouchi S; Kuwahara K; Sakata A; Ezaki T; Matsuoka S; Miyazaki J; Hirose S; Tamura T; Nariuchi H; Sakaguchi N; Department of Immunology, Kumamoto University School of Medicine,; Honjo, Japan.; A T cell activation antigen, Ly6C, is considered to be involved in the autoimmunity of some autoimmune-prone mice; however, the function of Ly6C remains largely unknown. We prepared a rat anti-mouse Ly6C monoclonal antibody (mAb) (S14) that inhibits the proliferation of peripheral T cells stimulated with anti-CD3 mAb
[Mortality among drug addicts: an Italian multicenter study. ESEDA group (Epidemiological Studies on Effects of Drug Abuse)]: Epidemiol Prev. 1997 Oct-Dec;21(4):265-71. Unique Identifier : AIDSLINE MED/98150486; To investigate temporal and geographical differences in mortality of intravenous drug users (IDUs) in Italy , a multicenter cohort of IDUs entering public treatment centres in Turin (n = 6975), Rome (n = 4660), Naples (n = 3785) and Cagliari (n = 1630) between 1980-1992, was enrolled
Determinants of squamous intraepithelial lesions (SIL) on Pap smear: the role of HPV infection and of HIV-1-induced immunosuppression. DIANAIDS Collaborative Study Group.: Eur J Epidemiol. 1997 Dec;13(8):937-43. Unique Identifier : AIDSLINE MED/98135692; Rezza G; Giuliani M; Branca M; Benedetto A; Migliore G; Garbuglia AR; D'Ubaldo C; Pezzotti P; Cappiello G; Pomponi Formiconi D; Suligoi B; Schiesari A; Ippolito G; Giacomini G; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome, Italy.; This study aimed to identify risk factors for squamous intraepithelial lesions (SIL) in women with known HIV status and to explore the association between SIL, HPV subtype, and HIV-induced immunosuppression. The study population consisted of women with known HIV serological status who were attending a network of 16 cl
Decreasing age at infection for homosexually acquired HIV in Italy: results of a back-calculation analysis.: Eur J Epidemiol. 1997 Dec;13(8):963-6. Unique Identifier : AIDSLINE MED/98135696; Marschner IC; Bosch RJ; Harvard School of Public Health, Boston 02115, USA.; marsch@sdac.harvard.edu; The age-specific incidence of homosexually acquired HIV in Italy was examined, based on 3918 AIDS cases diagnosed by the end of 1994 and reported by the end of 1995 through the national surveillance system. Using a smoothed back-calculation analysis, the estimated median age at infe
Characterization of the internal promoter of human T-cell leukemia virus type I.: FEBS Lett. 1998 Feb 13;423(1):25-30. Unique Identifier : AIDSLINE MED/98165680; Ariumi Y; Shimotohno K; Noda M; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.; The HTLV-I provirus contains two different promoters: the classical retroviral promoter in the 5 long terminal repeat LTR) and our previously identified second promoter in the pol gene just upstream of the ATG codon of the tax gene. Here, we demonstrated that the internal promoter expresses the gene for Tax but not R
Selective induction of CD8+ T cell functions by single substituted analogs of an antigenic peptide: distinct signals for IL-10 production.: FEBS Lett. 1998 Feb 20;423(2):138-42. Unique Identifier : AIDSLINE MED/98171300; Kohyama M; Kakehi M; Totsuka M; Hachimura S; Hisatsune T; Kaminogawa S; Department of Applied Biological Chemistry, The University of Tokyo,; Japan.; The CD8+ T cell clone 5F1 produces interleukin 10 (IL-10) and interferon gamma(IFN-gamma) in response to stimulation with a peptide corresponding to region 142-149 of bovine alpha(s1)-casein (p142-149). Ninety analog peptides derived from p142-149 with single amino acid substitutions of putative T cell receptor contac
HIV screening for pregnant women in south eastern France: evolution 1992-1994-1996.: Eur J Obstet Gynecol Reprod Biol. 1998 Jan;76(1):5-9. Unique Identifier : AIDSLINE MED/98142537; Rey D; Obadia Y; Carrieri MP; Moatti JP; Observatoire Regional de la Sante, Marseille, France.; OBJECTIVES: To assess the evolution of the HIV screening practices towards pregnant women between 1992 and 1996, in relation with the 1993 French mandatory obligation to offer prenatal HIV testing and recent therapeutic possibilities to reduce HIV vertical transmission. STUDY DESIGN: Three successive surveys (January
Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x.: Diabetologia. 1998 Feb;41(2):178-84. Unique Identifier : AIDSLINE MED/98158416; Lamhamedi-Cherradi SE; Luan JJ; Eloy L; Fluteau G; Bach JF; Garchon HJ; INSERM U25 and Institut Necker, Hopital Necker, Paris, France.; Activated lymphocytes of autoimmune non-obese diabetic (NOD) mice exhibit an increased resistance to programmed cell death (PCD) following withdrawal of interleukin-2 ( IL-2 ). In the present study, we found that resistance of NOD T lymphocytes to PCD was increased as ea
Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice.: Diabetologia. 1998 Feb;41(2):237-40. Unique Identifier : AIDSLINE MED/98158425; Tian J; Chau C; Kaufman DL; Department of Molecular and Medical Pharmacology, University of; California, Los Angeles 90095-1735, USA.; Little is known about the immunological impact of insulin administration other than it can boost insulin autoantibody levels. In particular, while the subcutaneous administration of a soluble foreign antigen (without adjuvant) is generally only weakly immunogenic in a naive animal, it is unknown what effect the subcut
Extra protection is prudent, not discriminatory [letter]: Gen Dent. 1997 Jul-Aug;45(4):332-3; discussion 334-8. Unique Identifier : AIDSLINE MED/98176416; Goleburn G
Ethics, or opinion? [letter]: Gen Dent. 1997 Jul-Aug;45(4):333-8. Unique Identifier : AIDSLINE MED/98176417; Gherardi RJ
Exploring ethical foundations [letter]: Gen Dent. 1997 Jul-Aug;45(4):334-8. Unique Identifier : AIDSLINE MED/98176418; Eichler D
First report of a healthy Indian heterozygous for delta 32 mutant of HIV-1 co-receptor-CCR5 gene.: Gene. 1998 Jan 30;207(2):141-7. Unique Identifier : AIDSLINE MED/98172746; Husain S; Goila R; Shahi S; Banerjea A; Laboratory of Virology, National Institute of Immunology, New Delhi,; India.; The beta-chemokine receptor, CCR5, is a major co-receptor for macrophage tropic non-syncytia-inducing isolates of HIV-1. Recently a 32 bp homozygous deletion in the coding region of CCR5 has been reported in a very small percentage (
The sodA gene of Haemophilus ducreyi encodes a hydrogen peroxide-inhibitable superoxide dismutase.: Gene. 1998 Jan 30;207(2):251-7. Unique Identifier : AIDSLINE MED/98172759; San Mateo LR; Toffer KL; Kawula TH; Department of Microbiology and Immunology, School of Medicine,; University of North Carolina at Chapel Hill 27599, USA.; Haemophilus ducreyi is the etiologic agent of the sexually transmitted disease chancroid, an ulcerative condition implicated in increased HIV transmission. There is increasing evidence for the roles of oxidative stress proteins including superoxide dismutase enzymes in the survival and persistence of pathogenic organi
Thrombophilic condition in HIV-infected patients [letter]: Haematologica. 1997 Nov-Dec;82(6):733-4. Unique Identifier : AIDSLINE MED/98160663; Trotti R; Rondanelli M; Anesi A
CD8+ T-cell clones in old mice.: Immunol Rev. 1997 Dec;160:139-44. Unique Identifier : AIDSLINE MED/98137153; Ku CC; Kotzin B; Kappler J; Marrack P; Howard Hughes Medical Institute, National Jewish Medical and Research; Center, Denver, Colorado 80206, USA.; Most old mice and human beings contain large clones of CD8+ alpha beta TCR+ T cells. In mice, clones bearing V beta 7 appear more frequently in animals infected with mouse hepatitis virus than in uninfected animals. This property is controlled by some non-MHC gene in the animals. The frequency of old mice containing s
Prevalence of HBsAg in patients with HIV infection and AIDS [letter]: Indian J Gastroenterol. 1998 Jan;17(1):35-6. Unique Identifier : AIDSLINE MED/98126668; Sehgal S; Mujtaba S
[Combination treatment of HIV infection]: Internist (Berl). 1997 Dec;38(12):1146-53. Unique Identifier : AIDSLINE MED/98126459; Goebel FD; Bogner JR; Medizinische Poliklinik der Ludwig-Maximilians-Universitat, Munchen.
Worldwide distribution of HTLV.: Jpn J Cancer Res. 1998 Jan;89(1):inside front cover. Unique Identifier : AIDSLINE MED/98169288; Tajima K; Division of Epidemiology, Aichi Cancer Center Research Institute,; Nagoya, Japan.
Characterization of mRNA expression of IkappaB alpha and NF-kappaB subfamilies in primary adult T-cell leukemia cells.: Jpn J Cancer Res. 1998 Jan;89(1):53-9. Unique Identifier : AIDSLINE MED/98169298; Inoue M; Matsuoka M; Yamaguchi K; Takatsuki K; Yoshida M; Department of Cellular and Molecular Biology, The Institute of Medical; Science, The University of Tokyo.; Tax protein of HTLV-1 activates the transcriptional capacity of the NF-kappaB family, resulting in up-regulation of various genes, which are linked to phenotypic alterations of HTLV-1-infected T cells. To understand NF-kappaB regulation in HTLV-1-infected leukemic cells in vivo, we analyzed expression of NF-kappaB and
Adsorptive endocytosis mediates the passage of HIV-1 across the blood-brain barrier: evidence for a post-internalization coreceptor.: J Cell Sci. 1998 Feb;111 ( Pt 4):533-40. Unique Identifier : AIDSLINE MED/98107969; Banks WA; Akerstrom V; Kastin AJ; Veterans Affairs Medical Center and Tulane Univeristy School of; Medicine, New Orleans, LA 70146, USA. bbbpts@mailhost.tcs.tulane.edu; HIV-1 induces the AIDS dementia complex and infects brain endothelial and glial cells. Because the endothelial cells comprising the blood-brain barrier (BBB) do not possess CD4 receptors or galactosylceramide binding sites, it is unclear how HIV-1 negotiates the BBB. Previous work
Breaking the silence, dismantling taboos: Latino novels on AIDS.: J Homosex. 1998;34(3-4):155-75. Unique Identifier : AIDSLINE MED/98166128; Sandoval Sanchez A; Department of Spanish, Mount Holyoke College, South Hadley, MA 01075,; USA.; As AIDS has ravaged the world in the last two decades, literature has played an important role in giving testimony of the epidemic. According to different communities and particular experiences, AIDS literature can offer ways of coping and surviving. In the last few years the U.S. Latino/a population has been highly a
Construction and characterization of a radio-iodinatable mutant of recombinant human CD4.: J Immunol Methods. 1997 Dec 29;210(2):215-25. Unique Identifier : AIDSLINE MED/98179127; Ferrer M; Godbout KL; Sullivan BJ; Austen DA; Sanderson CT; Kelley KC; Osburne MS; Harrison SC; van Schravendijk MR; Department of Molecular and Cellular Biology, Harvard University,; Cambridge, MA 02138, USA.; Recombinant soluble human CD4 (rsCD4) has been used in iodinated form to study the interaction of CD4 with its ligands. However, the utility of [125I]-rsCD4 is limited because rsCD4 is inefficiently iodinated and the iodinated protein is poorly active. The iodination properties of rsCD4 most likely reflect the poor ac
Widening social inequalities in mortality: the case of Barcelona, a southern European city.: J Epidemiol Community Health. 1997 Dec;51(6):659-67. Unique Identifier : AIDSLINE MED/98179653; Borrell C; Plasencia A; Pasarin I; Ortun V; Municipal Institute of Health, Barcelona, Spain.; OBJECTIVE: To analyse trends in mortality inequalities in Barcelona between 1983 and 1994 by comparing rates in those electoral wards with a low socioeconomic level and rates in the remaining wards. DESIGN: Mortality trends study. SETTING: The city of Barcelona ( Spain ). SUBJECTS: Th
Epidemiology of hepatitis C virus infection among injecting drug users in Australia.: J Epidemiol Community Health. 1997 Dec;51(6):692-7. Unique Identifier : AIDSLINE MED/98179658; Crofts N; Jolley D; Kaldor J; van Beek I; Wodak A; Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria,; Australia.; STUDY OBJECTIVE: To review the epidemiology of hepatitis C virus HCV) infection among injecting drug users (IDUs) in Australia , and consider needs for further research and prevention policies and programmes. DESIGN: (1) Review of the results of surveillance for HCV; (2) review o
CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease.: J Exp Med. 1998 Mar 16;187(6):855-64. Unique Identifier : AIDSLINE MED/98167922; Cong Y; Brandwein SL; McCabe RP; Lazenby A; Birkenmeier EH; Sundberg JP; Elson CO; Division of Gastroenterology and Hepatology, The University of Alabama; at Birmingham, Birmingham, Alabama 35294-0007, USA.; C3H/HeJBir mice are a new substrain that spontaneously develop colitis early in life. This study was done to determine the T cell reactivity of C3H/HeJBir mice to candidate antigens that might be involved in their disease. C3H/HeJBir CD4+ T cells were strongly reactive to antigens of the enteric bacterial flora, but n
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.: J Exp Med. 1998 Mar 16;187(6):875-83. Unique Identifier : AIDSLINE MED/98167924; Sallusto F; Lenig D; Mackay CR; Lanzavecchia A; Basel Institute for Immunology, CH-4005, Basel, Switzerland.; sallusto@bii.ch; Chemokines and their receptors are important elements for the selective attraction of various subsets of leukocytes. To better understand the selective migration of functional subsets of T cells, chemokine receptor expression was analyzed using monoclonal antibodies, RNase protection assays, and the response to distin
The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy.: J Exp Med. 1998 Mar 16;187(6):949-59. Unique Identifier : AIDSLINE MED/98167931; Tenner-Racz K; Stellbrink HJ; van Lunzen J; Schneider C; Jacobs JP; Raschdorff B; Grosschupff G; Steinman RM; Racz P; Medical Department, Eppendorf University, 20251 Hamburg, Germany.; The efficacy of triple drug therapy for HIV-1 infection encourages its early use to prevent damage to the immune system. We monitored the effects of such therapy on 12 patients with 14-75-mo histories of minimal disease, i.e., CD4+ counts constantly >500/microl and little or no lymph node enlargement. In this way, we
Comparison of protein surfaces using a genetic algorithm.: J Comput Aided Mol Des. 1997 Nov;11(6):557-69. Unique Identifier : AIDSLINE MED/98152048; Poirrette AR; Artymiuk PJ; Rice DW; Willett P; Krebs Institute for Biomolecular Research, Department of Information; Studies, University of Sheffield, U.K.; A genetic algorithm (GA) is described which is used to compare the solvent-accessible surfaces of two proteins or fragments of proteins, represented by a dot surface calculated using the Connolly algorithm. The GA is used to move one surface relative to the other to locate the most similar surface region between the t
Congenital and perinatal cytomegalovirus infection in infants born to mothers infected with human immunodeficiency virus.: J Pediatr. 1998 Feb;132(2):285-90. Unique Identifier : AIDSLINE MED/98165486; Mussi-Pinhata MM; Yamamoto AY; Figueiredo LT; Cervi MC; Duarte G; Department of Pediatrics, Faculty of Medicine of Ribeirao Preto,; University of Sao Paulo, Brazil.; OBJECTIVES: To determine the rates of congenital and perinatal cytomegalovirus ( CMV ) infection among infants born to mothers infected with HIV compared with infants born to mothers not infected with HIV from a CMV-immune, low
[Imaging of AIDS in children]: J Radiol. 1997 Dec;78(12):1233-43. Unique Identifier : AIDSLINE MED/98160943; Geoffray A; Spehl M; Chami M; Bosson N; Toppet V; Deville A; Fondation Lenval, Nice.; In children, AIDS is mainly related to materno-foetal transmission. Due to antiviral therapy and prevention of infections, the initially very poor prognosis has improved and the length of survival has increased. There are two groups of children: the first (25%) in which the disease occurs early and is very severe, a s
Infections and cancer: viruses are still prime suspects [news]: J Natl Cancer Inst. 1998 Mar 18;90(6):418-20. Unique Identifier : AIDSLINE MED/98180458; McCann J
[HIV screening in maternity clinics]: Katilolehti. 1998 Jan;103(1):23-4. Unique Identifier : AIDSLINE MED/98166574; Parviainen M; With a decision of the Finnish Department of Health and Social Welfare the HIV-screenings have been extended from the beginning of the year. The most important reason for this is the development of the medical treatment. With the present treatment, the transmitting of the HIV-infection from mother to child can be prev
The effect of exercise training on aerobic fitness, immune indices, and quality of life in HIV+ patients.: Med Sci Sports Exerc. 1998 Jan;30(1):11-6. Unique Identifier : AIDSLINE MED/98133786; Stringer WW; Berezovskaya M; O'Brien WA; Beck CK; Casaburi R; Harbor-UCLA Medical Center, Division of Respiratory and Critical, Care; Physiology and Medicine, Torrance, CA 90509, USA.; PURPOSE: Thirty four HIV+ patients participated in a 6-wk aerobic exercise training program to determine whether exercise improved aerobic fitness, immune indices, and quality of life. METHODS: Subjects were assigned to three groups: control (no regular aerobic exercise), moderate exercise, and heavy exercise training
Production of TNFalpha and IL-6 by activated whole blood from HIV-1 infected patients detected by a one-stage procedure: relationship with the phenotype of HIV-1 isolates.: Microbiol Immunol. 1997;41(12):939-46. Unique Identifier : AIDSLINE MED/98151143; Benyoucef S; Hober D; Shen L; Ajana F; De Groote D; Bocket-Mouton L; Gerard Y; Lion G; Vilain V; Wattre P; Laboratoire de Virologie, CHU, Lille, France.; Diluted whole blood (WB) culturing may be the most appropriate milieu in which to study cytokine production in vitro. We tested TNFalpha and IL-6 production using small volumes of WB (25 microl) from HIV-1 positive patients with a one-step procedure that combines WB stimulation with LPS, PHA and cytokine measurement.
Bioactive fragment of human IL-1beta [163-171] modulates the immune response to synthetic peptides of HIV.: Microbiol Immunol. 1997;41(12):965-74. Unique Identifier : AIDSLINE MED/98151146; Gokulan K; Rao DN; Department of Biochemistry, All India Institute of Medical Sciences,; New Delhi.; The activation of T helper cells specific for viral antigens is critical for antibody production and the generation of cytotoxic T cells during retroviral infection. In this study, we examined the effect of linking HIV peptides with a bioactive fragment of human interleukin-1beta (IL-1beta) (163-171) on the induction
Application of equine infectious anemia virus core proteins produced in a baculovirus expression system to serological diagnosis.: Microbiol Immunol. 1997;41(12):975-80. Unique Identifier : AIDSLINE MED/98151147; Kong XG; Pang H; Sugiura T; Sentsui H; Onodera T; Matsumoto Y; Akashi H; National Institute of Animal Health, Tsukuba, Ibaraki, Japan.; Equine infectious anemia virus (EIAV) core proteins were obtained from a baculovirus expression system. Recombinant baculoviruses rBVs) highly expressed the Gag precursor and p26 antigens in an rBV-infected Sf21 cell culture supernatant. Enzyme-linked immunosorbent assay (ELISA) and agar gel immunodiffusion (AGID) wer
Mechanisms of allografted tumor rejection: the roles of T cells in allograft rejection mediated by a type of bone marrow-derived macrophage.: Microbiol Immunol. 1997;41(12):981-90. Unique Identifier : AIDSLINE MED/98151148; Ushio-Umeda Y; Yoshida R; Department of Cell Biology, Osaka Bioscience Institute, Suita, Japan.; Allografted tumor rejection does not occur in the absence of T cells, but the main effector cells responsible for the rejection are allograft-induced macrophages (AIM). We examined the roles of T cells in the AIM-mediated rejection of Meth A (H-2d) tumor cells from C57BL/6 (H-2b) mice. Irradiation of C57BL/6 mice abro
[HIV infection: antiretroviral therapy 1997. Consensus statement of the International AIDS Society-USA Panel]: Med Monatsschr Pharm. 1997 Dec;20(12):343-6. Unique Identifier : AIDSLINE MED/98096987
Sexual transmission and the natural history of human herpesvirus 8 infection.: N Engl J Med. 1998 Apr 2;338(14):948-54. Unique Identifier : AIDSLINE MED/98172957; Martin JN; Ganem DE; Osmond DH; Page-Shafer KA; Macrae D; Kedes DH; Center for AIDS Prevention Studies, Department of Epidemiology and; Biostatistics, San Francisco General Hospital, CA, USA.; BACKGROUND: Although human herpesvirus 8 (HHV-8) has been suspected to be the etiologic agent of Kaposi s sarcoma, little is known about its seroprevalence in the population, its modes of transmission, and its natural history. METHODS: The San Francisco Men s Health Study, begun in 1984, is a study of a population-bas
Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus.: Neuroscience. 1998 Apr;83(3):691-700. Unique Identifier : AIDSLINE MED/98144547; Krucker T; Toggas SM; Mucke L; Siggins GR; Scripps Research Institute and AIDS Research Center, Department of; Neuropharmacology, La Jolla, CA 92037, USA.; The human immunodeficiency virus type-1 envelope glycoprotein gp120 is shed from the virus and from infected cells and thus can diffuse and interact with a variety of central nervous system cells. Transgenic mice constitutively expressing glial fibrillary acidic protein-driven gp120 from brain astrocytes display neuro
Home medical tests increase in use and popularity.: N J Med. 1998 Feb;95(2):27-9. Unique Identifier : AIDSLINE MED/98166402; Noonan SS
HIV resources [letter]: N J Med. 1998 Feb;95(2):8. Unique Identifier : AIDSLINE MED/98166397; Apuzzio J
Making sense of the law [letter]: N J Med. 1998 Feb;95(2):8, 12. Unique Identifier : AIDSLINE MED/98166398; Harris C
Transient increase in CD45RO expression on T lymphocytes in infected newborns.: Pediatr Res. 1998 Feb;43(2):283-90. Unique Identifier : AIDSLINE MED/98133445; Tezuka T; Sugita K; Mizobe N; Goi K; Miyamoto N; Nakamura M; Kagami K; Yokoyama T; Nakazawa S; Department of Pediatrics, Yamanashi Medical University, Japan.; Although infections are a significant cause of mortality and long-term morbidity of newborns, the early diagnosis of neonatal infections remains difficult. It has been shown recently that up-regulation of CD45RO expression on umbilical cord lymphocytes might be a good indicator for intrauterine viral infections. To ev
AIDS and dentistry: 1997.: Northwest Dent. 1997 Jan-Feb;76(1):19-23, 25-8, 30-4. Unique Identifier : AIDSLINE MED/98148862; Rhodus NL; Little JW; University of Minnesota School of Dentistry, Minneapolis 55455, USA.
Mutational analysis of the tRNA3Lys/HIV-1 RNA (primer/template) complex.: Nucleic Acids Res. 1998 Mar 1;26(5):1198-204. Unique Identifier : AIDSLINE MED/98136200; Isel C; Keith G; Ehresmann B; Ehresmann C; Marquet R; Unite Propre de Recherche No. 9002 du Centre National de la Recherche; Scientifique, Institut de Biologie Moleculaire et Cellulaire, 15 rue; Rene Descartes, 67084 Strasbourg cedex, France.; Retroviruses use a specific tRNA, whose 3 end is complementary to the 18 nucleotides of the primer binding site (PBS), to prime reverse transcription. Previous work has shown that initiation of HIV-1 reverse transcription is a specific process, in contrast with the subsequent elongation phase. HIV-1 reverse transcrip
Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.: Nucleic Acids Res. 1998 Mar 1;26(5):1294-301. Unique Identifier : AIDSLINE MED/98136213; Greger IH; Demarchi F; Giacca M; Proudfoot NJ; Sir William Dunn School of Pathology, University of Oxford, South; Parks Road, Oxford OX1 3RE, UK.; Transcriptional interference between adjacent genes has been demonstrated in a variety of biological systems. To study this process in RNA polymerase II (pol II) transcribed genes we have analysed the effect of transcription on tandem HIV-1 promoters integrated into the genome of HeLa cells. We show that transcription
Specific cleavage of a target RNA from HIV-1 by mammalian tRNA 3' processing endoribonuclease directed by an RNA heptamer.: Nucleic Acids Symp Ser. 1997;(36):22-5. Unique Identifier : AIDSLINE MED/98138682; Nashimoto M; Kaspar R; JT Life Science Research Laboratory, Kanagawa, Japan.; Mammalian tRNA 3 processing endoribonuclease (3 tRNase) can recognize pre-tRNA-like complexes between a 5 half tRNA(Arg) and a 3 half tRNA(Arg) with a 3 trailer, and can cleave the 3 half tRNA(Arg) after the discriminator nucleotide (Nashimoto M., 1996, RNA, 2:523-534). 3 tRNase cleaved the 3 half tRNA(Arg) in
Rational and combinatorial strategies for designing oligonucleotides targeted to RNA structures.: Nucleic Acids Symp Ser. 1997;(36):39-41. Unique Identifier : AIDSLINE MED/98138687; Toulme JJ; Le Tinevez R; Boiziau C; Dausse E; INSERM U386, IFR Pathologies Infectieuses, Universite Victor Segalen,; Bordeaux, France.; Many RNA structures play a key role in the regulation of gene expression. We designed synthetic oligonucleotides able to interact with folded RNA regions (see Toulme et al., Biochimie 1996) 78, 663-673, for a review). We have demonstrated that a decanucleotide can form a triple helix with the stem of the hairpin respo
The effect of pseudouridine and pH on the structure and dynamics of the anticodon stem-loop of tRNA(Lys,3).: Nucleic Acids Symp Ser. 1997;(36):56-7. Unique Identifier : AIDSLINE MED/98138692; Durant PC; Davis DR; Department of Medicinal Chemistry, University of Utah, Salt Lake City; 84112, USA.; The anticodon stem-loop hairpin of tRNA(Lys,3) was synthesized and the solution structure determined by NMR spectroscopy. The hairpin is thermodynamically stabilized by pseudouridine as determined by UV Tm measurements, and the local loop structure is stabilized with base-stacking of the nucleosides in the anticodon l
Cryptosporidiosis in persons with HIV infection.: Postgrad Med J. 1997 Nov;73(865):713-6. Unique Identifier : AIDSLINE MED/98179708; Ramratnam B; Flanigan TP; Miriam Hospital, Brown University School of Medicine, Providence, RI,; USA.; Cryptosporidium parvum is an ubiquitous protozoan parasite that is a major cause of diarrhoea in individuals infected with human immunodeficiency virus. The hallmarks of infection include profuse watery diarrhoea which may become chronic in the severely immunosuppressed individual. No uniformly effective therapy exist
Tissue disposition of zidovudine and its phosphorylated metabolites in zidovudine-treated healthy and retrovirus infected mice.: Pharm Res. 1998 Jan;15(1):139-44. Unique Identifier : AIDSLINE MED/98148541; Chow HH; Brookshier G; Li P; Department of Pharmacy Practice and Science, College of Pharmacy,; University of Arizona, Tucson 85721, USA. chow@pharmacy.arizona.edu; PURPOSE: The purpose of this study was to examine the effect of chronic AZT treatment on the in vivo tissue disposition of the phosphorylated AZT metabolites in healthy and retrovirus infected mice. METHODS: Female C57BL/6 mice at 12 weeks after inocu
Retroviruses and sexual size dimorphism in domestic cats (Felis catus L.).: Proc R Soc Lond B Biol Sci. 1998 Feb 7;265(1392):167-73. Unique Identifier : AIDSLINE MED/98154455; Pontier D; Fromont E; Courchamp F; Artois M; Yoccoz NG; UMR-CNRS 5558 'Biometrie, Genetique et Biologie des Populations,; Universite Claude Bernard Lyon 1, Villeurbanne, France.; dpontier@biomserv.univ-lyon1.fr; Hochberg and co-workers have predicted that an increase in host adult mortality due to parasites is balanced by an earlier age at first reproduction. In polygynous species we hypothesize that such a pattern would lead to diverging selection pressure on body size between sexes and increased sexual size dimorphism. In p
Dynamics of cytotoxic T-lymphocyte exhaustion.: Proc R Soc Lond B Biol Sci. 1998 Feb 7;265(1392):191-203. Unique Identifier : AIDSLINE MED/98154457; Wodarz D; Klenerman P; Nowak MA; University Hospital Zurich, Institute of Experimental Immunology,; Switzerland.; We examine simple mathematical models to investigate the circumstances under which the dynamics of cytotoxic T-lymphocyte CTL) activation and differentiation may result in the loss of virus specific CD8+ cells, a process known as CTL exhaustion. We distinguish between two general classes of viruses: (i) viruses infect
[HIV follow-up. New data on pathophysiology and treatment of psychiatric disturbances in the course of AIDS]: Psychiatr Pol. 1997 Mar-Apr;31(2):197-209. Unique Identifier : AIDSLINE MED/98061234; Nasierowski T; Matsumoto H; I Klinika Psychiatryczna AM w Warszawie.; In the article summarized here, the authors present the most important achievements in the research on pathogenesis and treatment of AIDS, with particular consideration of psychiatric disturbances occurring in the course of infection by AIDS. Since the 1 st of January 1993, a new definition of AIDS has been obligatory
[Psychiatric disorders and sensory deprivation in AIDS. Case report]: Psychiatr Pol. 1997 Mar-Apr;31(2):211-4. Unique Identifier : AIDSLINE MED/98061235; Nasierowski T; Kaminska-Kopicz E; I Klinika Psychiatryczna AM w Warszawie.; In AIDS there are several opportunistic infections that may occur. Some of them can lead to blindness (for example toxoplasmosis, CMV ). It is known that psychiatric disorders can also occur in AIDS. Both situations can take place at the same time. In that case w
Evaluation of serologic markers for transfusion transmitted infectious diseases for allogeneic blood donors in Puerto Rico.: P R Health Sci J. 1997 Sep;16(3):255-8. Unique Identifier : AIDSLINE MED/98093628; Martinez-Diaz H; Frye-Maldonado AC; Climent-Peris C; Velez-Rosario R; Department of Pathology, University of Puerto Rico.; The purpose of this project is to assess the prevalence of serologic markers for transfusion transmitted infectious disease in allogeneic blood donors of the American Red Cross Blood Services (ARCBS) in Puerto Rico . Four hundred records were randomly selected from a population
Pulmonary cryptococcoma with CD4 lymphocytopenia and meningitis in an HIV-negative patient.: Respir Med. 1998 Jan;92(1):120-2. Unique Identifier : AIDSLINE MED/98179760; Ho CL; Chang BC; Hsu GC; Wu CP; Department of Medicine, Tri-Service General Hospital, National Defense; Medical Center, Taipei, Taiwan, Republic of China.
[Multicentric Castleman's disease with mediastinal involvement in a patient with HIV infection]: Rev Mal Respir. 1997 Dec;14(6):481-3. Unique Identifier : AIDSLINE MED/98157692; Azoulay E; Herry I; Antoine M; Mayaud C; Cadranel J; Service de Pneumologie et Reanimation Respiratoire, Hopital Tenon,; Paris.; Castleman s disease is most often seen by a thoracic physician as a mediastinal tumour which is discovered fortuitously and whose surgical excision leads to a cure. We report a case of a patient of 30 who was seropositive for HIV and was suffering from Castleman s disease initially localised to the mediastinum. The di
[Manifestations, diagnosis and treatment of non-tuberculous mycobacterial infections in patients with HIV infection]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S142-51. Unique Identifier : AIDSLINE MED/98157684; Payen MC; De Wit S; Clumeck N; CHU Saint-Pierre, Bruxelles, Belgique.; The most frequent bacterial infections in patients infected with HIV and suffering from AIDS are non-tuberculous mycobacterial infections. Their incidence is increasing all the more as the survival of profoundly immunocompromised patients is prolonged. There are unknown factors as regards the precise origin of these i
[The natural history of tuberculosis infection and skin tuberculin reaction]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S27-32. Unique Identifier : AIDSLINE MED/98157674; Flament-Saillour M; Perronne C; Service des Maladies Infectieuses et Tropicales, Hopital; Raymond-Poincare, Garches.; Though most often asymptomatic, tuberculous infection induces a delayed hypersensitivity reaction in the host by activating cellular immunity thus rendering the host refractory, a priori , to a new infection; at least provided that the infecting dose is not massive or that the immune system of the host is not comprom
[The bacteriology of tuberculosis and non-tuberculosis mycobacterial infections]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S33-48. Unique Identifier : AIDSLINE MED/98157675; Wyplosz B; Truffot-Pernot C; Robert J; Jarlier V; Grosset J; Laboratoire Central de Bacteriologie, Groupe Hospitalier; Pitie-Salpetriere, Paris.; Changing incidence and nature of mycobacterial infections subsequent to the historical regression of tuberculosis and the acquired human immunodeficiency syndrome (AIDS) epidemic, as well as the development of new technical tools for molecular biology, have profoundly modified the methods used for the bacteriological
[Tuberculous infection and pulmonary tuberculosis in adults]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S49-59. Unique Identifier : AIDSLINE MED/98157676; Huchon G; Service de Pneumologie, Hopital Ambroise-Pare, Boulogne.; A tuberculous infection is the result of inhalation of tubercle bacilli either in great numbers or in subjects with diminished immunity. Clinical tuberculosis will only occur in 10 per cent of subjects following a first infection (primary tuberculosis) or subsequently (secondary tuberculosis or by a reactivation of a
[Pulmonary manifestations of tuberculosis in children]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S60-71. Unique Identifier : AIDSLINE MED/98157677; Olivier C; Service de Pediatrie Generale, Hopital Louis-Mourier, Colombes.; The occurrence of tuberculosis in children is dependent on a contagious bacillus carrying adult. Among 500 cases notified annually, perhaps 5 or 6% of the total infectious reservoir in France , 75% have parenchymal pulmonary disease and/or lymph nodes. These tuberculous diseases onl
[The epidemiology of tuberculosis and of the resistance to antitubercular agents]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S8-18. Unique Identifier : AIDSLINE MED/98157672; Ait Khaled N; Enarson D; Billo N; Union Internationale Contre la Tuberculose et les Maladies; Respiratoires (UICTMR), Paris.; Tuberculosis is once more a subject of world wide preoccupation; since 1985 a disturbing recrudescence of this disease has been noted in numerous countries related to population growth and the worsening of poverty in those countries without natural resources, and disadvantaged groups living on the margins of society i
[Antitubercular chemotherapy]: Rev Mal Respir. 1997 Dec;14 Suppl 5:S88-104. Unique Identifier : AIDSLINE MED/98157679; Jouveshomme S; Dautzenberg B; Service de Pneumologie et Reanimation Respiratoire, Groupe Hospitalier; Pitie-Salpetriere, Paris.; Treatment of tuberculosis has three major goals: healing the patient, preventing selection of resistant strains and control transmission of tuberculosis. A 6 month regimen consisting of isoniazid, rifampin with addition of pyrazinamide for 2 months is the preferred treatment for pulmonary and extra-pulmonary tuberculo
Advances in HIV/AIDS statistical methodology over the past decade.: Stat Med. 1998 Jan 15;17(1):1-25. Unique Identifier : AIDSLINE MED/98125007; Foulkes MA; Division of AIDS, National Institute of Allergy and Infectious; Diseases, Bethesda, MD 20892, USA.; This review provides a synopsis of the developments over the past decade in mathematical and statistical methodology in response to the AIDS epidemic. This review includes highlights of the development of epidemic models, approaches to describing the natural history of HIV infection, and the methods developed for HIV
The use of simulation and bootstrap in information-based group sequential studies.: Stat Med. 1998 Jan 15;17(1):75-87. Unique Identifier : AIDSLINE MED/98125012; Scharfstein DO; Tsiatis AA; Department of Biostatistics, Johns Hopkins School of Public Health,; Baltimore, MD 21205-2179, USA.; In this paper, we present an information-based design and monitoring procedure which applies to any type of model for any type of group sequential study provided there is a unique parameter of interest one can estimate efficiently. Simulation techniques are described to handle the design phase of this procedure. Since
Nanolasers.: Sci Am. 1998 Mar;278(3):56-61. Unique Identifier : AIDSLINE MED/98148683; Gourley PL
Tuberculosis in England and Wales in 1993: results of a national survey. Public Health Laboratory Service/British Thoracic Society/Department of Health Collaborative Group.: Thorax. 1997 Dec;52(12):1060-7. Unique Identifier : AIDSLINE MED/98177544; Kumar D; Watson JM; Charlett A; Nicholas S; Darbyshire JH; PHLS Communicable Disease Surveillance Centre, London, UK.; BACKGROUND: A national survey of tuberculosis notifications in England and Wales was carried out in 1993 to determine the notification rate of tuberculosis and the trends in the occurrence of disease by ethnic group in comparison with the findings of similar surveys in 1978/79, 1983, and 1988. The prevalence of HIV in
Elevated free phenytoin and free valproic acid concentrations in sera of patients infected with human immunodeficiency virus.: Ther Drug Monit. 1998 Feb;20(1):63-7. Unique Identifier : AIDSLINE MED/98146505; Dasgupta A; McLemore JL; Department of Pathology and Laboratory Medicine, University of; Texas-Houston Health Science Center 77030, USA.; Seizures are common in patients infected with human immunodeficiency virus (HIV). Phenytoin and valproic acid are common anticonvulsants, and both drugs are strongly bound to serum albumin. Because patients infected with HIV are often on polytherapy, using homeopathic medicines, and may also have hypoalbuminemia, elev
[Acquired immunodeficiency syndrome in Moroccan children. A report of 8 cases]: Tunis Med. 1996 Jun-Jul;74(6-7):299-304. Unique Identifier : AIDSLINE MED/98166979; Lahbabi MS; Benomar S; Chaoui DM; Sqalli M; Service pediatrie 1 Hopital d'Enfant CHU Ibn Rochd Casablanca, Maroc.
[Novelties in tuberculosis]: Tunis Med. 1997 Dec;75(12):898-902. Unique Identifier : AIDSLINE MED/98168158; Bouacha H; Aouina H; Baccar MA; Azzabi S; Khirouni S; Lahidheb D
[Parvovirus B19--a cause of hepatitis in patients with liver transplantation, anemia in HIV positive individuals and encephalopathies in children]: Ugeskr Laeger. 1998 Mar 9;160(11):1653. Unique Identifier : AIDSLINE MED/98183145; Christensen LS; Hoiby N
Apoptotic killing of CD4+ T lymphocytes in HIV-1-infected PHA-stimulated PBL cultures is mediated by CD8+ LAK cells.: Virology. 1998 Feb 15;241(2):169-80. Unique Identifier : AIDSLINE MED/98160771; Wang L; Klimpel GR; Planas JM; Li H; Cloyd MW; Department of Pathology, University of Texas Medical Branch, Galveston; 77555-1019, USA.; In vitro infection of PHA-stimulated, normal CD4+ human peripheral blood T lymphocytes (PBLs) with several HIV-1 isolates did not result in cytopathology, despite high levels of virus replication and the fact that some of these isolates were cytopathic in certain cell lines. In contrast, infection of unfractionated PB
Differences in chemokine coreceptor usage between genetic subtypes of HIV-1.: Virology. 1998 Feb 15;241(2):181-8. Unique Identifier : AIDSLINE MED/98160772; Tscherning C; Alaeus A; Fredriksson R; Bjorndal A; Deng H; Littman DR; Fenyo EM; Albert J; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.; HIV-1 uses chemokine coreceptors for cell entry. CXCR4 is the major coreceptor for T-cell-line-adapted isolates and CCR5 for non-T-cell-line-adapted isolates. This study investigated if coreceptor usage differs between genetic subtypes of HIV-1. Eighty-one primary isolates representing nine different genetic subtypes
Persistent HTLV-I infection of breast luminal epithelial cells: a role in HTLV transmission?: Virology. 1998 Feb 15;241(2):200-14. Unique Identifier : AIDSLINE MED/98160774; Southern SO; Southern PJ; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA. sarka@lenti.med.umn.edu; Human T cell leukemia viruses are predominantly transmitted from mother to child by breastfeeding. Endemic levels of HTLV infection are associated with ethnic groups that have traditionally practised long-term breastfeeding. In the course of long-term lactation, we have found that human milk contains leukocytes and ep
Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems.: Virology. 1998 Feb 15;241(2):224-33. Unique Identifier : AIDSLINE MED/98160776; Luo T; Douglas JL; Livingston RL; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38105, USA.; Retroviruses have been extensively used in the development of gene transfer systems. Recently, there has been a great deal of interest in the use of lentiviruses for gene transfer because they infect nondividing cells. Human immunodeficiency virus (HIV) has been the lentivirus most often used for this purpose, but its
Chimeras containing influenza NS1 and HIV-1 Rev protein sequences: mechanism of their inhibition of nuclear export of Rev protein-RNA complexes.: Virology. 1998 Feb 15;241(2):234-50. Unique Identifier : AIDSLINE MED/98160777; Chen Z; Li Y; Krug RM; Department of Molecular Biology and Biochemistry, Rutgers University,; Piscataway, New Jersey 08855, USA.; Nuclear RNA export mediated by the HIV-1 Rev protein is inhibited by chimeric proteins in which the wild-type Rev protein is covalently linked to amino acid sequences of the NS1 protein of influenza A virus (NS1A protein), a protein that inhibits nuclear RNA export. These chimeric molecules function not only in cis bu
Evolution of human immunodeficiency virus type 1 envelope sequences in infected individuals with differing disease progression profiles.: Virology. 1998 Feb 15;241(2):251-9. Unique Identifier : AIDSLINE MED/98160778; Shankarappa R; Gupta P; Learn GH Jr; Rodrigo AG; Rinaldo CR Jr; Gorry MC; Mullins JI; Nara PL; Ehrlich GD; Department of Pathology, University of Pittsburgh, Pennsylvania 15261,; USA.; Sequence variation displayed by the human immunodeficiency virus type 1 (HIV-1) has been proposed to be linked to the pathogenesis of acquired immunodeficiency syndrome (AIDS). To assess viral evolution during the course of infection, we evaluated sequence variability in the env variable domains in four HIV-1-infected
Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS.: Virology. 1998 Feb 15;241(2):260-8. Unique Identifier : AIDSLINE MED/98160779; Green KA; Noelle RJ; Green WR; Department of Microbiology, Dartmouth Medical School, Lebanon, New; Hampshire 03756, USA.; In genetically susceptible C57BL/6 mice the LP-BM5 isolate of murine retroviruses causes profound splenomegaly, lymphadenopathy, hypergammaglobulinemia, and an immunodeficiency syndrome bearing many similarities to the pathologies seen in AIDS. Because of these similarities, which also include terminal B cell lymphoma
Characterization of the cytotoxic factor(s) released from thymic dendritic cells upon human immunodeficiency virus type 1 infection.: Virology. 1998 Feb 15;241(2):285-97. Unique Identifier : AIDSLINE MED/98160782; Beaulieu S; Lafontaine M; Richer M; Courchesne I; Cohen EA; Bergeron D; Departement de Microbiologie et Immunologie, Universite de Montreal,; Succursale Centre-ville, Quebec, Canada.; We previously demonstrated that infection of primary human thymic dendritic cells (DCs) with laboratory strains of HIV leads to the release of soluble factor(s) which induced thymocyte killing. In the present paper, we extend the characterization of this process. Our results reveal that primary HIV-1 isolates are simi
Human T-cell leukemia virus type 1 Tax protein induces the expression of lymphocyte chemoattractant SDF-1/PBSF.: Virology. 1998 Feb 15;241(2):298-303. Unique Identifier : AIDSLINE MED/98160783; Arai M; Ohashi T; Tsukahara T; Murakami T; Hori T; Uchiyama T; Yamamoto N; Kannagi M; Fujii M; Department of Immunotherapeutics, Tokyo Medical and Dental University,; Japan.; We investigated the mechanism of lymphocyte infiltration into tissues infected with human T-cell leukemia virus type 1 HTLV-1). The cytokine SDF-1/PBSF is a highly efficient chemoattractant for lymphocytes. Reverse transcription-PCR analysis showed that among various human T-cell lines, those infected with HTLV-1 sele
Glomerular lesions in HIV-infected patients: a Yale University Department of Medicine Residency Peer-Teaching Conference.: Yale J Biol Med. 1997 Mar-Apr;70(2):161-73. Unique Identifier : AIDSLINE MED/98152867; Wrone EM; Carey H; Reilly RF; Department of Medicine, Yale University School of Medicine, New Haven,; Connecticut, USA.; HIV-associated nephropathy (HIVAN) is a clinicopathologic entity characterized by heavy proteinuria, absence of edema and an irreversible decline in renal function. Findings on renal biopsy include: collapsed glomerular capillaries; visceral glomerular epitheliosis; microcystic tubules; mesangial prominence; and endot
[Morphological study of Enterocytozoon bineousi in patients with AIDS and chronic diarrhea]: Acta Gastroenterol Latinoam. 1997;27(4):241-5. Unique Identifier : AIDSLINE MED/98064170; Velasquez JN; Di Risio C; Carnevale S; Corti M; Benetucci J; Bossini JP; Cabrera M; Chertcoff A; Labbe JH; Rodriguez M; Bessaso H; Guarnera EA; Departamento de Parasitologia, Instituto Nacional de Microbiologia Dr.; Carlos G. Malbran, Buenos Aires, Argentina.; Microsporidia are protozoan parasites responsible for significant gastrointestinal disease in patients infected with the human immunodeficiency virus. We report the clinical features of three patients with chronic diarrhea and intestinal microsporidiosis caused by Ente
The effects of human immunodeficiency virus in the central nervous system.: Adv Virus Res. 1998;50:1-47. Unique Identifier : AIDSLINE MED/98181623; Kolson DL; Lavi E; Gonzalez-Scarano F; Department of Neurology and Microbiology, University of Pennsylvania; School of Medicine, Philadelphia 19104-6146, USA.; More than a decade after the first description of HIV DNA in the nervous system the pathophysiology of HIVD remains largely enigmatic, with data supporting a number of potential mechanisms for the development of neuronal dysfunction. Nevertheless, a few key findings have considerable support in the literature devoted
Pathogenesis of AIDS-related lymphomas: molecular and histogenetic heterogeneity.: Am J Pathol. 1998 Mar;152(3):623-30. Unique Identifier : AIDSLINE MED/98161506; Gaidano G; Carbone A; Dalla-Favera R; Division of Internal Medicine, University of Torino at Novara, Italy.
Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis.: Am J Pathol. 1998 Mar;152(3):659-65. Unique Identifier : AIDSLINE MED/98161511; Westmoreland SV; Rottman JB; Williams KC; Lackner AA; Sasseville VG; Division of Comparative Pathology, New England Regional Primate; Research Center, Harvard Medical School, Southborough, Massachusetts; 01772-9102, USA.; Although the mechanisms of human immunodeficiency virus (HIV) neuroinvasion, neuronal injury, and subsequent development of HIV-1-associated AIDS dementia complex are not fully understood, a correlation between monocyte/macrophage infiltrates in the brain and neurological disease e
Detection of HTLV-1 by polymerase chain reaction in situ hybridization in adult T-cell leukemia/lymphoma.: Am J Pathol. 1998 Mar;152(3):683-9. Unique Identifier : AIDSLINE MED/98161515; Setoyama M; Kerdel FA; Elgart G; Kanzaki T; Byrnes JJ; Department of Dermatology, Kagoshima University Faculty of Medicine,; Sakuragaoka, Japan. setoyama@med5.kufm.kagoshima-u.ac.jp; A method for nonradioactive polymerase chain reaction in situ hybridization was developed and used to determine the distribution of human T-lymphotropic virus type I (HTLV-I) proviral DNA in paraffin-embedded surgical specimens of adult T-cell leukemia/lymphoma (ATLL). As controls, we used biopsy samples of five cases
Randomized, placebo-controlled trial of paroxetine versus imipramine in depressed HIV-positive outpatients.: Am J Psychiatry. 1998 Mar;155(3):367-72. Unique Identifier : AIDSLINE MED/98162368; Elliott AJ; Uldall KK; Bergam K; Russo J; Claypoole K; Roy-Byrne PP; Department of Psychiatry and Behavioral Sciences, University of; Washington, Seattle 98104, USA. aelliott@u.washington.edu; OBJECTIVE: This study examined whether a selective serotonin reuptake inhibitor (paroxetine) had comparable efficacy but greater tolerability than a tricyclic antidepressant (imipramine) in depressed patients with HIV infection. METHOD: Seventy-five HIV-positive patients (45% of whom had AIDS) were blindly and randoml
[Free radicals and HIV infection]: Ann Biol Clin (Paris). 1997 Nov-Dec;55(6):565-71. Unique Identifier : AIDSLINE MED/98160896; Rabaud C; Tronel H; Fremont S; May T; Canton P; Nicolas JP; Service de maladies infectieuses et tropicales, CHU de Nancy, Hopitaux; de Brabois, Vandoeuvre-les-Nancy.; In HIV infected patients, the increase of the concentration of free radicals is related to: a depletion of protective system glutathione peroxidase, superoxide dismutase, vitamin E, selenium ...), and an increased production of free radicals superoxide anion, hydrogen peroxide, hydroxil radical) consecutive to the act
Effect of fluconazole on indinavir pharmacokinetics in human immunodeficiency virus-infected patients.: Antimicrob Agents Chemother. 1998 Feb;42(2):223-7. Unique Identifier : AIDSLINE MED/98139004; De Wit S; Debier M; De Smet M; McCrea J; Stone J; Carides A; Matthews C; Deutsch P; Clumeck N; Division of Infectious Diseases, C.H.U. Saint-Pierre, Brussels,; Belgium.; To evaluate a potential pharmacokinetic interaction of coadministration of fluconazole, and indinavir, a human immunodeficiency virus (HIV) protease inhibitor, 13 patients were enrolled in a multiple-dose, three-period, placebo-controlled, crossover study. Patients were randomly assigned to receive indinavir at 1,000
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents.: Antimicrob Agents Chemother. 1998 Feb;42(2):241-53. Unique Identifier : AIDSLINE MED/98139008; Sanglard D; Ischer F; Koymans L; Bille J; Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois,; Lausanne, Switzerland. dsanglar@eliot.unil.ch; The cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) of yeasts is involved in an important step in the biosynthesis of ergosterol. Since CYP51A1 is the target of azole antifungal agents, this enzyme is potentially prone to alterations leading to resistance to these agents. Among them, a decrease in the affini
A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs.: Antimicrob Agents Chemother. 1998 Feb;42(2):269-76. Unique Identifier : AIDSLINE MED/98139012; Hertogs K; de Bethune MP; Miller V; Ivens T; Schel P; Van Cauwenberge A; Van Den Eynde C; Van Gerwen V; Azijn H; Van Houtte M; Peeters F; Staszewski S; Conant M; Bloor S; Kemp S; Larder B; Pauwels R; VIRCO, Central Virological Laboratory, Edegem, Belgium.; kurt.hertogs@virco.be; Combination therapy with protease (PR) and reverse transcriptase RT) inhibitors can efficiently suppress human immunodeficiency virus (HIV) replication, but the emergence of drug-resistant variants correlates strongly with therapeutic failure. Here we describe a new method for high-throughput analysis of clinical samp
Pharmacokinetics and absolute bioavailability of oral foscarnet in human immunodeficiency virus-seropositive patients.: Antimicrob Agents Chemother. 1998 Feb;42(2):293-7. Unique Identifier : AIDSLINE MED/98139016; Noormohamed FH; Youle MS; Higgs CJ; Martin-Munley S; Gazzard BG; Lant AF; Department of Clinical Pharmacology and Therapeutics, Imperial College; School of Medicine, Chelsea and Westminster Hospital, London, United; Kingdom. f.noormohamed@lc.ac.uk; The pharmacokinetics, absolute bioavailability, accumulation, and tolerability over 8 days of an oral formulation of foscarnet (90 mg/kg of body weight once daily [QD] [n = 6], 90 mg/kg twice daily [BID] [n = 6], and 180 mg/kg QD [n = 31) were investigated in 15 asymptomatic, human immunodeficiency virus-seropositive
Single-dose pharmacokinetics of indinavir and the effect of food.: Antimicrob Agents Chemother. 1998 Feb;42(2):332-8. Unique Identifier : AIDSLINE MED/98139022; Yeh KC; Deutsch PJ; Haddix H; Hesney M; Hoagland V; Ju WD; Justice SJ; Osborne B; Sterrett AT; Stone JA; Woolf E; Waldman S; Merck Research Laboratories, West Point, Pennsylvania 19486, USA.; kuang_yeh@merck.com; Indinavir sulfate is a human immunodeficiency virus type 1 HIV-1) protease inhibitor indicated for treatment of HIV infection and AIDS in adults. The purpose of this report is to summarize single-dose studies which characterized the pharmacokinetics o
Mathematical modeling of the interrelationship of CD4 lymphocyte count and viral load changes induced by the protease inhibitor indinavir.: Antimicrob Agents Chemother. 1998 Feb;42(2):358-61. Unique Identifier : AIDSLINE MED/98139027; Drusano GL; Stein DS; Department of Medicine, Albany Medical College, New York 12208, USA.; GLDrusano@aol.com; While CD4 cell counts are widely used to predict disease progression in human immunodeficiency virus (HIV)-infected patients, they are poorly explanatory of the progression to AIDS or death after the introduction of chemotherapy. Changes in HIV load (as measured by RNA PCR) have been shown to be a much better predicto
TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus.: Antimicrob Agents Chemother. 1998 Feb;42(2):383-8. Unique Identifier : AIDSLINE MED/98139031; Uckun FM; Chelstrom LM; Tuel-Ahlgren L; Dibirdik I; Irvin JD; Langlie MC; Myers DE; Wayne Hughes Institute, St. Paul, Minnesota 55113, USA.; faith_uckun@mercury.ih.org; We have evaluated the clinical potential of TXU anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-sev
Zalcitabine population pharmacokinetics: application of radioimmunoassay.: Antimicrob Agents Chemother. 1998 Feb;42(2):409-13. Unique Identifier : AIDSLINE MED/98139036; Adams JM; Shelton MJ; Hewitt RG; DeRemer M; DiFrancesco R; Grasela TH; Morse GD; Department of Pharmacy Practice, State University of New York at; Buffalo, Amherst 14260, USA.; Zalcitabine population pharmacokinetics were evaluated in 44 human immunodeficiency virus-infected patients (39 males and 5 females) in our immunodeficiency clinic. Eighty-one blood samples were collected during routine clinic visits for the measurement of plasma zalcitabine concentrations by radioimmunoassay 1.84+/-1
The Cys607-->Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients.: Antimicrob Agents Chemother. 1998 Feb;42(2):444-6. Unique Identifier : AIDSLINE MED/98139045; Baldanti F; Underwood MR; Talarico CL; Simoncini L; Sarasini A; Biron KK; Gerna G; Servizio di Virologia, IRCCS Policlinico S. Matteo, Pavia, Italy.; Two ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strains recovered from an AIDS patient (strain VR4990) and a heart transplant recipient (strain VR5474) showed a Cys607-->Tyr change in the UL97-encoded phosphotransferase. No amino acid substitutions were observed in the
A mutation at position 190 of human immunodeficiency virus type 1 reverse transcriptase interacts with mutations at positions 74 and 75 via the template primer.: Antimicrob Agents Chemother. 1998 Feb;42(2):447-52. Unique Identifier : AIDSLINE MED/98139046; Boyer PL; Gao HQ; Hughes SH; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Maryland 21702-1201, USA.; We have analyzed amino acid substitutions at position G190 in the reverse transcriptase (RT) of human immunodeficiency virus type 1 HIV-1). The mutation G190E, which is responsible for resistance to certain nonnucleoside inhibitors, results in RT that has significantly less polymerase activity and that is less process
Estimate of the frequency of human immunodeficiency virus type 1 protease inhibitor resistance within unselected virus populations in vitro.: Antimicrob Agents Chemother. 1998 Feb;42(2):478-80. Unique Identifier : AIDSLINE MED/98139056; Tucker SP; Stiebel TR Jr; Potts KE; Smidt ML; Bryant ML; G. D. Searle, Searle Research and Development, St. Louis, Missouri; 63198, USA. simon.t@biota.com.au; The frequency of drug-resistant human immunodeficiency virus type 1 (HIV-1) variants in virus populations not previously exposed to drug was determined in vitro by using HIV-1RF and the protease inhibitor SC-55389A. Two variants with single mutations responsible for drug resistance (V82A and N88S) were quantifiably is
Prevalence of parvovirus B19 infection among patients with human immunodeficiency virus infection in Barcelona, Spain [letter]: Arch Intern Med. 1998 Mar 23;158(6):680-1. Unique Identifier : AIDSLINE MED/98180532; Negredo E; Domingo P; Rabella N; Lopez-Contreras J; Fontanet A; Orellana I
Human immunodeficiency virus sexual risk reduction in homeless men with mental illness.: Arch Gen Psychiatry. 1998 Mar;55(3):266-72. Unique Identifier : AIDSLINE MED/98169040; Susser E; Valencia E; Berkman A; Sohler N; Conover S; Torres J; Betne P; Felix A; Miller S; Department of Psychiatry, Columbia University School of Medicine, New; York State Psychiatric Institute, New York 10032, USA.; BACKGROUND: The spread of human immunodeficiency virus infection to impaired groups has intensified the challenge for its prevention; control of the epidemic now requires behavioral change among persons with limited ability to sustain attention and learn. In this randomized clinical trial, we tested an intervention to
Characterization of an integrase mutant of feline immunodeficiency virus.: Arch Virol. 1998;143(1):1-14. Unique Identifier : AIDSLINE MED/98166861; Tomonaga K; Itagaki SI; Kashiwase H; Kawaguchi Y; Inoshima Y; Ikeda Y; Mikami T; Department of Veterinary Microbiology, University of Tokyo, Japan.; The role of the integrase region of feline immunodeficiency virus FIV) in viral replication was examined using an integrase mutant clone of FIV which carries a frameshift mutation in the region. Upon transfection, although the integrase mutant was able to release virus-like particles into the supernatant from the tran
Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E.: Arch Virol. 1998;143(1):157-62. Unique Identifier : AIDSLINE MED/98166873; Inoshima Y; Miyazawa T; Kohmoto M; Ikeda Y; Sato E; Hohdatsu T; Mathiason-Dubard C; Hoover EA; Mikami T; Department of Veterinary Microbiology, Graduate School of Agricultural; and Life Sciences, University of Tokyo, Japan.; Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV gen
Detection of bovine immunodeficiency-like virus infection in experimentally infected calves.: Arch Virol. 1998;143(1):181-9. Unique Identifier : AIDSLINE MED/98166876; Baron T; Betemps D; Mallet F; Cheynet V; Levy D; Belli P; Centre National d'Etudes Veterinaires et Alimentaires, Lyon, France.; Detection of BIV virus infection by serological means, PCR and virus isolation in experimentally infected calves is described. Viral sequences were specifically detected by PCR in peripheral blood mononuclear cells (PBMCs), with primer systems located in the gag, pol and tat regions of the viral genome. An enzyme-link
Construction and characterization of a stably transformed HeLa cell line in which the expression of bovine herpesvirus 1 ICP0 BICP0) is induced by tetracycline.: Arch Virol. 1998;143(1):35-48. Unique Identifier : AIDSLINE MED/98166864; Steinmann NA; Nunez R; Koppel R; Ackermann M; Institute of Virology, University of Zurich, Switzerland.; To explore the effects BICP0 (a principal transactivator of BHV-1 gene expression) on viral promoter elements, we established a cell line in which the expression of BICP0 is regulated by tetracycline. A hybrid promoter containing reiterated copies of the tet-operator (tet-O) and a minimal herpesviral alpha gene transi
Facilitation of HIV-1 isolation from patients by neuraminidase.: Arch Virol. 1998;143(1):85-95. Unique Identifier : AIDSLINE MED/98166868; Xin X; Shioda T; Fukushima M; Hu H; Oka S; Iwamoto A; Nagai Y; Department of Viral Infection, University of Tokyo, Japan.; We previously reported that infectivities of human and other non-human lentiviruses incl