Capture of an early fusion-active conformation of HIV-1 gp41.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Capture of an early fusion-active conformation of HIV-1 gp41.

Nat Struct Biol. 1998 Apr;5(4):276-9. Unique Identifier : AIDSLINE MED/98206292
Furuta RA; Wild CT; Weng Y; Weiss CD; Office of Vaccines, Center for Biologics Evaluation and Research, Food; and Drug Administration, Bethesda, Maryland 20892-4555, USA.

Abstract: Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformational changes involving the coiled coil domain of gp41 are required for entry. Capture of this fusion-active conformation of Env provides insights into the early events leading to Env-mediated membrane fusion.

Keywords: *HIV Envelope Protein gp41/CHEMISTRY *HIV Envelope Protein gp41/METABOLISM *HIV-1/PHYSIOLOGY *Membrane Fusion/PHYSIOLOGY *Protein Conformation

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