Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination.

Nat Med. 1998 Apr;4(4):421-7. Unique Identifier : AIDSLINE MED/98206864
Cheynier R; Gratton S; Halloran M; Stahmer I; Letvin NL; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris.

Abstract: The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCG inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV variant was noted, probably as a result of the infiltration of activated antigen-specific T cell clones as opposed to infection by blood borne virus in situ. The dynamics of SIV quasispecies in peripheral blood suggests sequential waves of viral replication, illustrating the role of antigenic stimulation as a driving force in viral dissemination and pathogenesis.
Keywords: *BCG Vaccine/PHARMACOLOGY *Gene Products, env/GENETICS *Hypersensitivity, Delayed *Simian Acquired Immunodeficiency Syndrome/IMMUNOLOGY *SIV/PHYSIOLOGY *T-Lymphocytes/IMMUNOLOGY *Virus Replication/IMMUNOLOGY

KWDbcgvaccine/pharmacologyKWDgeneproducts,env/geneticsKWDhypersensitivity,delayedKWDsimianacquiredimmunodeficiencysyndrome/immunologyKWDsiv/physiologyKWDt-lymphocytes/immunologyKWDvirusreplication/immunology
980730
M9871346

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