Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease [see comments]

Nat Med. 1998 Apr;4(4):428-34. Unique Identifier : AIDSLINE MED/98206865
Lunardi-Iskandar Y; Bryant JL; Blattner WA; Hung CL; Flamand L; Gill P; Hermans P; Birken S; Gallo RC; Institute of Human Virology, University of Maryland, Baltimore; 21201-1192, USA.

Abstract: The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi's sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factors is not due to the native hCG heterodimer, including its purified subunits or its major degradation product, the beta-core. Using gel permeation chromatography of the clinical grade hCG and urine concentrates from pregnant women, we demonstrate that an as yet unidentified hCG associated factor HAF) with anti-HIV, anti-SIV, anti-KS and pro-hematopoietic activities elutes as two peaks corresponding to 15-30 kDa and 2-4 kDa.
Keywords: *Biological Factors/PHARMACOLOGY *Biological Factors/URINE *Genome, Viral *Gonadotropins, Chorionic/URINE *HIV-1/PHYSIOLOGY *Pregnancy/URINE *Simian Acquired Immunodeficiency Syndrome/DRUG THERAPY *Virus Replication/DRUG EFFECTS

KWDbiologicalfactors/pharmacologyKWDbiologicalfactors/urineKWDgenome,viralKWDgonadotropins,chorionic/urineKWDhiv-1/physiologyKWDpregnancy/urineKWDsimianacquiredimmunodeficiencysyndrome/drugtherapyKWDvirusreplication/drugeffects
Comment in: Nat Med 1998 Apr;4(4):390-1
980730
M9871345

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