Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus.

Nat Med. 1998 Apr;4(4):435-40. Unique Identifier : AIDSLINE MED/98206866
Lee H; Veazey R; Williams K; Li M; Guo J; Neipel F; Fleckenstein B; Lackner A; Desrosiers RC; Jung JU; New England Regional Primate Research Center, Harvard Medical School,; Southborough, MA 01772-9102, USA.

Abstract: At a position equivalent to the gene encoding the saimiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi's sarcoma-associated herpesvirus (KSHV) contains a distinct open reading frame called K1. Although KSHV and HVS are related members of the rhadinovirus subgroup of gamma herpesviruses, K1 and STP exhibit no similarity in amino acid sequence or in structural organization. Since STP is required for the oncogenic potential of HVS, we investigated the functional consequence of K1 expression. Expression of the K1 gene in rodent fibroblasts produced morphologic changes and focus formation indicative of transformation. A recombinant herpesvirus in which the STP oncogene of HVS was replaced with K1, immortalized primary T lymphocytes to IL-2 independent growth and induced lymphoma in common marmosets. These results demonstrate the transforming potential of the K1 gene of KSHV.
Keywords: *Genes, Viral *Herpesvirus, Kaposi Sarcoma-Associated/GENETICS *Open Reading Frames *Sarcoma, Kaposi/VIROLOGY *Viral Proteins/BIOSYNTHESIS *Viral Proteins/GENETICS

KWDgenes,viralKWDherpesvirus,kaposisarcoma-associated/geneticsKWDopenreadingframesKWDsarcoma,kaposi/virologyKWDviralproteins/biosynthesisKWDviralproteins/genetics
980730
M9871344

Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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