Influence of hepatitis G virus infection on liver disease. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Influence of hepatitis G virus infection on liver disease.

Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):916-9. Unique Identifier : AIDSLINE MED/98155061
Diamantis ID; Kouroumalis E; Koulentaki M; Fasler-Kan E; Schmid PA; Hirsch HH; Buhler H; Gyr K; Battegay M; Outpatient Department of Internal Medicine, University Hospital Basel,; Switzerland.

Abstract: The influence of hepatitis G virus (HGV) infection on disease activity in hepatitis C related and unrelated liver disease was investigated in 254 individuals using an EIA polymerase chain reaction assay for HGV. One hundred patients had chronic hepatitis C, 26 primary biliary cirrhosis, and 30 alcoholic liver cirrhosis. In addition, 51 hepatitis B surface antigen HBsAg)-positive and 47 anti-hepatitis C virus (HCV)-positive blood donors were screened. Hepatitis G virus was detected in 18% of patients with chronic hepatitis C, 13% of patients with alcoholic liver cirrhosis, 11% of patients with primary biliary cirrhosis, 10% of anti-HCV-positive blood donors, and 2% of HBsAg-positive blood donors. Virus load and alanine aminotransferase (ALT) levels did not differ significantly in patients with HCV alone versus patients coinfected with HCV and HGV. However, mild liver fibrosis correlated with HGV coinfection. Hepatitis G virus did not influence ALT levels or liver damage in liver disease unrelated to viral infection.
Keywords: *Hepatitis Agents, GB *Hepatitis, Viral, Human/COMPLICATIONS *Liver Diseases/COMPLICATIONS

KWDhepatitisagents,gbKWDhepatitis,viral,human/complicationsKWDliverdiseases/complications
980730
M9871321

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