Bacteremia and respiratory involvement by Alcaligenes xylosoxidans in patients infected with the human immunodeficiency virus. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Bacteremia and respiratory involvement by Alcaligenes xylosoxidans in patients infected with the human immunodeficiency virus.

Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):933-8. Unique Identifier : AIDSLINE MED/98155065
Manfredi R; Nanetti A; Ferri M; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universita di Bologna, Italy.

Abstract: Seven cases of Alcaligenes xylosoxidans bacteremia and/or respiratory disease in patients infected with the human immunodeficiency virus (HIV) are described. Reported only thrice previously in this setting, these bacterial complications occurred during different phases of HIV infection and were associated with leukopenia-neutropenia in four patients and a central vascular catheter in two. Although the majority of cases were diagnosed after day 3 of hospitalization, a distinct source of infection was never identified. In four patients with advanced underlying disease, a polymicrobial infection was present. In vitro resistance to aminoglycosides, first-generation cephalosporins, and aztreonam was identified, but treatment with fluoroquinolones, piperacillin, or an aminoglycoside in combination with either ceftazidime or pefloxacin was successful in all cases. The relevance of Alcaligenes xylosoxidans and related species of gram-negative non-glucose fermenting bacilli as opportunistic pathogens in the immunocompromised host and in the setting of HIV infection is briefly reviewed.
Keywords: *Alcaligenes *AIDS-Related Opportunistic Infections/MICROBIOLOGY *Bacteremia/COMPLICATIONS *Respiratory Tract Infections/COMPLICATIONS

KWDalcaligenesKWDaids-relatedopportunisticinfections/microbiologyKWDbacteremia/complicationsKWDrespiratorytractinfections/complications
980730
M9871320

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