1998

HIV-1 viral load and CD4 cell count in untreated children with vertically acquired asymptomatic or mild disease. Paediatric European Network for Treatment of AIDS (PENTA).: AIDS. 1998 Mar 5;12(4):F1-8. Unique Identifier : AIDSLINE MED/98178983; BACKGROUND: Plasma HIV-1 RNA levels are high in vertically infected infants. Information in older children is limited, particularly in those who have not received antiretroviral therapy. OBJECTIVES: To describe the relationships between HIV-1 RNA, age and CD4 cell count in untreated vertically infected children. DESIG
Suicidal behaviours, euthanasia and AIDS.: AIDS. 1998 Mar 5;12(4):339-47. Unique Identifier : AIDSLINE MED/98178984; Starace F; Sherr L; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.
Inhibition of HIV-1 gp120-induced apoptosis in neuroblastoma SK-N-SH cells by an antisense oligodeoxynucleotide against p53.: AIDS. 1998 Mar 5;12(4):349-54. Unique Identifier : AIDSLINE MED/98178985; Yeung MC; Geertsma F; Liu J; Lau AS; Department of Pediatrics, University of California, San Francisco,; USA.; OBJECTIVES: This study examines the cytotoxicity potential and the mechanism of toxicity of the HIV-1 gp120 on human neuroblastoma cells. DESIGN: Previous data from our group have suggested that the HIV-1 envelope protein gp120 promotes the secretion of tumor necrosis factor-alpha and other factors by astrocytes and m
Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex.: AIDS. 1998 Mar 5;12(4):355-63. Unique Identifier : AIDSLINE MED/98178986; Kerr SJ; Armati PJ; Guillemin GJ; Brew BJ; Centre for Immunology, St Vincent's Hospital, Sydney, Australia.; OBJECTIVE: Concentrations of quinolinic acid, an N-methyl-D-aspartate agonist, are often elevated for long periods of time in the cerebrospinal fluid (CSF) and brain tissue of patients with AIDS dementia complex (ADC). This study was designed to test the hypothesis that chronic exp
Human cytomegalovirus product UL44 downregulates the transactivation of HIV-1 long terminal repeat.: AIDS. 1998 Mar 5;12(4):365-72. Unique Identifier : AIDSLINE MED/98178987; Boccuni MC; Campanini F; Battista MC; Bergamini G; Dal Monte P; Ripalti A; Landini MP; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; OBJECTIVE: Human cytomegalovirus (HCMV) is often isolated from HIV-1-infected patients and the two viruses can infect the same cell type giving rise to direct bidirectional interactions. Whereas the long terminal repeat (LTR) transactivation ability of HCMV immediate early gene (IE
Impaired cytokine production by neutrophils isolated from patients with AIDS.: AIDS. 1998 Mar 5;12(4):373-9. Unique Identifier : AIDSLINE MED/98178988; Gasperini S; Zambello R; Agostini C; Trentin L; Tassinari C; Cadrobbi P; Semenzato G; Cassatella MA; Department of General Pathology, University of Verona, Italy.; OBJECTIVES: To determine the ability of neutrophils isolated from HIV-seropositive patients to produce proinflammatory cytokines. DESIGN: The in vitro responsiveness of polymorphonuclear neutrophils (PMN) and peripheral blood mononuclear cells (PBMC) to lipopolysaccharide (LPS), used in the presence or absence of inte
Does hepatitis C virus co-infection accelerate clinical and immunological evolution of HIV-infected patients?: AIDS. 1998 Mar 5;12(4):381-8. Unique Identifier : AIDSLINE MED/98178989; Piroth L; Duong M; Quantin C; Abrahamowicz M; Michardiere R; Aho LS; Grappin M; Buisson M; Waldner A; Portier H; Chavanet P; Service des Maladies Infectieuses et Tropicales, Hopital d'Enfants,; CHU Dijon, France.; OBJECTIVE: To study the influence of hepatitis C virus (HCV) co-infection on clinical and immunological evolution of HIV-infected patients. DESIGN: A longitudinal study of HIV-infected individuals with or without HCV infection, identified at the Infectious Diseases Department of Dijon University Hospital and enrolled
Cerebrospinal fluid HIV-1 RNA levels: correlation with HIV encephalitis.: AIDS. 1998 Mar 5;12(4):389-94. Unique Identifier : AIDSLINE MED/98178990; Cinque P; Vago L; Ceresa D; Mainini F; Terreni MR; Vagani A; Torri W; Bossolasco S; Lazzarin A; Infectious Diseases Division, San Raffaele Scientific Institute,; Milan, Italy.; OBJECTIVE: Neuropathological abnormalities induced by HIV-1 are not always predictable on the basis of the presence of HIV-related neurological symptoms. HIV-1 RNA load was measured in the cerebrospinal fluid (CSF) of HIV-infected patients to verify whether it could be a marker of HIV-induced neuropathology. DESIGN AN
Short-term evolution of HIV-1 viraemia and CD4+ cell counts in patients who have a primary mutation to zidovudine.: AIDS. 1998 Mar 5;12(4):395-8. Unique Identifier : AIDSLINE MED/98178991; Rubio A; Leal M; Rey C; Pineda JA; Sanchez-Quijano A; Lissen E; Department of Biochemistry, Virgen del Rocio University Hospital,; Seville, Spain.; OBJECTIVE: To investigate the different responses to antiretroviral treatment including zidovudine, of patients harbouring HIV with primary resistance to zidovudine, serum viral load, and CD4+ cell counts, for 24 weeks in a group of antiretroviral-naive patients with the codon 215 mutation of the HIV pol gene and in a
Reduction of the viral load of HIV-1 after the intraperitoneal administration of dextrin 2-sulphate in patients with AIDS.: AIDS. 1998 Mar 5;12(4):399-409. Unique Identifier : AIDSLINE MED/98178992; Shaunak S; Thornton M; John S; Teo I; Peers E; Mason P; Krausz T; Davies DS; Department of Infectious Diseases, Imperial College School of; Medicine, Hammersmith Hospital, London, UK.; OBJECTIVE: To determine the safety and efficacy of the sulphated polysaccharide, dextrin 2-sulphate, when delivered to the lymphatic circulation by the peritoneal route. DESIGN: An open Phase I/II dose-escalation clinical study in which six patients with AIDS were treated with seven courses of dextrin 2-sulphate each
Treatment of HIV-related fluconazole-resistant oral candidosis with D0870, a new triazole antifungal.: AIDS. 1998 Mar 5;12(4):411-6. Unique Identifier : AIDSLINE MED/98178993; Cartledge JD; Denning DW; Dupont B; Clumeck N; De Wit S; Midgley J; Hawkins DA; Gazzard BG; Chelsea and Westminster Hospital, London, UK.; OBJECTIVES: To evaluate the efficacy and tolerance of D0870 in the treatment of HIV-related fluconazole-resistant oro-oesophageal candidosis. DESIGN: Multicentre open study. PATIENTS: HIV-seropositive patients with oro-oesophageal candidosis despite at least 7 days of treatment with fluconazole at doses of 100 mg per
The relationship of clinic experience with advanced HIV and survival of women with AIDS.: AIDS. 1998 Mar 5;12(4):417-24. Unique Identifier : AIDSLINE MED/98178994; Laine C; Markson LE; McKee LJ; Hauck WW; Fanning TR; Turner BJ; Center for Research in Medical Education and Health Care, Division of; Internal Medicine, Jefferson Medical College, Thomas Jefferson; University, Philadelphia, Pennsylvania 19107, USA.; OBJECTIVE: Hospital and physician experience have been linked to improved outcomes for persons with HIV. Because many HIV-infected patients receive care in clinics, we studied clinic HIV experience and survival for women with AIDS. DESIGN: Retrospective cohort study of women with AIDS whose dominant sources of care we
HIV infection and risk factors among female sex workers in southern Vietnam.: AIDS. 1998 Mar 5;12(4):425-32. Unique Identifier : AIDSLINE MED/98178995; Thuy NT; Nhung VT; Thuc NV; Lien TX; Khiem HB; Pasteur Institute, Ho Chi Minh City, Vietnam.; OBJECTIVES: To determine the extent of HIV infection among female commercial sex workers (CSW), to identify risk factors, and to provide baseline data for developing and targeting prevention measures. SUBJECTS AND METHODS: A total of 968 female CSW were enrolled in a cross-sectional study from August 1995 to October 1
Safety evaluation of nonoxynol-9 gel in women at low risk of HIV infection.: AIDS. 1998 Mar 5;12(4):433-7. Unique Identifier : AIDSLINE MED/98178996; Van Damme L; Niruthisard S; Atisook R; Boer K; Dally L; Laga M; Lange JM; Karam M; Perriens JH; STD/HIV Research and Intervention Unit, Institute of Tropical; Medicine, Antwerp, Belgium.; OBJECTIVE: To determine the safety of a vaginal microbicide, COL-1492, containing 52.5 mg nonoxynol-9, applied once daily for 14 days among healthy volunteers. METHODS: A randomized, double-blind controlled trial with three arms, COL-1492 gel versus placebo gel versus no-treatment controls, was conducted. Outcomes of
Profound and unanticipated anemia with lamivudine-zidovudine combination therapy in zidovudine-experienced patients with HIV infection [letter]: AIDS. 1998 Mar 5;12(4):439-40. Unique Identifier : AIDSLINE MED/98178997; Hester EK; Peacock JE Jr
Indinavir-induced renal failure [letter]: AIDS. 1998 Mar 5;12(4):440-1. Unique Identifier : AIDSLINE MED/98178998; Chen SC; Nankivell BJ; Dwyer DE
Is the combination of hepatitis and indinavir potentially dangerous? [letter]: AIDS. 1998 Mar 5;12(4):441-2. Unique Identifier : AIDSLINE MED/98178999; Jeurissen FJ; Schneider MM; Borleffs JC
Quick and easy detection of cytomegalovirus retinitis using conjunctival swab and polymerase chain reaction in AIDS patients [letter]: AIDS. 1998 Mar 5;12(4):443-4. Unique Identifier : AIDSLINE MED/98179000; Chiou SH; Liu JH; Chung YM; Wong WW; Liu SM; Weng WS; Liu WT; Chen KY; Chow KC
CCR-5 genotype and sexual transmission of HIV-1 [letter]: AIDS. 1998 Mar 5;12(4):444-5. Unique Identifier : AIDSLINE MED/98179001; O'Brien TR; Padian NS; Hodge T; Goedert JJ; O'Brien SJ; Carrington M
Molecular epidemiology characterization of a multidrug-resistant Mycobacterium bovis outbreak amongst HIV-positive patients [letter]: AIDS. 1998 Mar 5;12(4):445-6. Unique Identifier : AIDSLINE MED/98179002; Gori A; Marchetti G; Catozzi L; Nigro C; Ferrario G; Rossi MC; Degli Esposti A; Orani A; Franzetti F
Is it necessary to conduct trials with trimethoprim-sulphamethoxazole amongst HIV-infected individuals in Africa? [letter]: AIDS. 1998 Mar 5;12(4):447. Unique Identifier : AIDSLINE MED/98179003; Samb B; Badiane M; Kony S; Larouze B; Faye MA; Sow PS; Badiane S; Metro A; Costagliola D; Ndoye I; Delaporte E; Coll-Seck AM; Coulaud JP
Reduction in oropharyngeal candidiasis following introduction of protease inhibitors [letter]: AIDS. 1998 Mar 5;12(4):447-8. Unique Identifier : AIDSLINE MED/98179004; Hood S; Bonington A; Evans J; Denning D
Progressive multifocal leukoencephalopathy regression with highly active antiretroviral therapy [letter]: AIDS. 1998 Mar 5;12(4):449. Unique Identifier : AIDSLINE MED/98179005; Teofilo E; Gouveia J; Brotas V; da Costa P
Lesbian sex and risk of HIV transmission [letter]: AIDS. 1998 Mar 5;12(4):450-1. Unique Identifier : AIDSLINE MED/98179006; Raiteri R; Baussano I; Giobbia M; Fora R; Sinicco A
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma.: Am J Respir Cell Mol Biol. 1998 Apr;18(4):453-62. Unique Identifier : AIDSLINE MED/98202492; Padrid PA; Mathur M; Li X; Herrmann K; Qin Y; Cattamanchi A; Weinstock J; Elliott D; Sperling AI; Bluestone JA; Department of Medicine, University of Chicago, Chicago, Illinois; 60637, USA. ppadrid@flowcity.bsd.uchicago.edu; Complete T-cell activation requires two distinct signals, one delivered via the T-cell receptor, and the second co-stimulatory signal through CD28/B7 ligation. Previous studies showed that the blockade of CD28/B7 ligation alters differentiation of Th1/Th2 lymphocyte subsets in vitro and in vivo. The present study was
We should routinely offer HIV screening in pregnancy. Pregnancy Subgroup of the Herpes Simplex Advisory Panel [comment]: Br J Obstet Gynaecol. 1998 Mar;105(3):249-51. Unique Identifier : AIDSLINE MED/98194175; Mercey D; Nicoll A; Department of Sexually Transmitted Diseases, UCL Medical School,; London.
Mandatory prenatal screening for the human immunodeficiency virus: the experience in south-eastern France of a national policy, 1992-1994 [see comments]: Br J Obstet Gynaecol. 1998 Mar;105(3):269-74. Unique Identifier : AIDSLINE MED/98194179; Rey D; Carrieri MP; Obadia Y; Pradier C; Moatti JP; Regional Center for Disease Control of South-Eastern France,; Marseille.; OBJECTIVE: To evaluate the impact of the 1993 French National Policy which made it mandatory to offer screening for the presence of human immunodeficiency virus (HIV) to all pregnant women who planned to give birth, although women remained free to refuse the test. DESIGN: Successive surveys in April 1992 and May 1994
A randomised trial of mode of delivery in women infected with the human immunodeficiency virus.: Br J Obstet Gynaecol. 1998 Mar;105(3):281-5. Unique Identifier : AIDSLINE MED/98194181; Newell ML; Parazzini F; Mandelbrot L; Peckham C; Semprini A; Bazin B; Darbyshire J; Sanchez E; Pardi G; Institute of Child Health, London, UK.; OBJECTIVE: During the pilot phase of a trial to evaluate the effectiveness of caesarean section delivery compared with vaginal delivery in reducing mother-to-child transmission of human immunodeficiency virus (HIV) infection, the feasibility of randomisation to mode of delivery was assessed. DESIGN: At 36 weeks of pre
RNA-protein interactions in the Tat-trans-activation response element complex determined by site-specific photo-cross-linking.: Biochemistry. 1998 Mar 24;37(12):4235-43. Unique Identifier : AIDSLINE MED/98190001; Wang Z; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical School,; University of Medicine and Dentistry of New Jersey, Piscataway 08854,; USA.; Transcriptional regulation in human immunodeficiency virus type 1 HIV-1) requires specific interactions of Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5 -end of all HIV transcripts. We have used a site-specific cross-linking method based on 6-thioguan
'Unsafe protected sex': qualitative insights on measures of sexual risk.: AIDS Care. 1998 Feb;10(1):105-14. Unique Identifier : AIDSLINE MED/98197268; Quirk A; Rhodes T; Stimson GV; Department of Social Science and Medicine, Imperial College School of; Medicine, London, UK.; To describe forms of unsafe protected sex (vaginal or anal intercourse where condoms are used unsafely) among a sample of drug users in London, data are drawn from a qualitative study of the sexual and drug taking lifestyles of opioid and stimulant users. Depth one-to-one interviews (n = 96) elicited detailed descript
Psychological and socio-medical aspects of HIV/AIDS: a reflection on publications in AIDS care (1989-1995).: AIDS Care. 1998 Feb;10(1):115-21. Unique Identifier : AIDSLINE MED/98197269; Bennett L; Rose D; Jackson A; Thomas S; Department of Behavioural and Social Sciences, University of Sydney,; NSW, Australia.; It is necessary to consider the content and methods of AIDS social research publications for these represent research advances as well as current issues of concern for practitioners, communities and researchers alike. This article critically examines some of the research that has been conducted to date into social asp
Secondary prevention for youths living with HIV.: AIDS Care. 1998 Feb;10(1):17-34. Unique Identifier : AIDSLINE MED/98197261; Rotheram-Borus MJ; Miller S; Department of Psychiatry, University of California, Los Angeles, USA.; As the number of youths infected with HIV rises, secondary prevention programmes are needed to help youths living with HIV meet three goals: (1) increase self-care behaviours, medical adherence and health-related interactions; (2) reduce transmission acts; and (3) enhance their quality of life. This article describes
Safe sex or safe love: competing discourses?: AIDS Care. 1998 Feb;10(1):35-47. Unique Identifier : AIDSLINE MED/98197262; Rosenthal D; Gifford S; Moore S; Centre for the Study of Sexually Transmissible Diseases, La Trobe; University, Victoria, Australia.; The way in which sex may be constructed as safe through its relationship with love is the concern of this study. Interviews with 112 heterosexual women and men from discos and bars in Melbourne, Australia , catering to single adults revealed the pervasive construction of sex wi
The role of disclosure in coping with HIV infection.: AIDS Care. 1998 Feb;10(1):49-60. Unique Identifier : AIDSLINE MED/98197263; Holt R; Court P; Vedhara K; Nott KH; Holmes J; Snow MH; Department of Psychology, The University, Newcastle upon Tyne, UK.; A qualitative investigation was conducted to explore the role of disclosure in HIV infection. Forty homosexual and bisexual men completed a short demographic questionnaire and participated in a one-to-one, semi-structured interview. The interview was designed to address a variety of personal, interpersonal and organiz
HIV/AIDS, micro-ethics and macro-ethics [editorial]: AIDS Care. 1998 Feb;10(1):5-6. Unique Identifier : AIDSLINE MED/98197259; Mann JM
A multicentre study on the causes of death among Italian injecting drug users. AIDS has overtaken overdose as the principal cause of death.: AIDS Care. 1998 Feb;10(1):61-7. Unique Identifier : AIDSLINE MED/98197264; Mezzelani P; Quaglio GL; Venturini L; Lugoboni F; Friedman SR; Des Jarlais DC; Institute of Clinica Medica, University of Verona, Italy.; mezzelani@cmib.univr.it; The causes of death among injecting drug users. (IDUs) are still being discussed worldwide. We analysed the causes of death among IDUs attending 26 centres for drug users in North-Eastern Italy from 1985 to 1994. The study of a total number of 1,022 deaths reveals the following: (1)
Changes in prostitution and the AIDS epidemic in Thailand.: AIDS Care. 1998 Feb;10(1):69-79. Unique Identifier : AIDSLINE MED/98197265; Hanenberg R; Rojanapithayakorn W; Family Health International, Bangkok, Thailand.; The HIV/AIDS epidemic which broke out in Thailand 1988 was mainly caused by the widespread patronage of prostitutes. The Thai authorities responded with programmes which encouraged the use of condoms in commercial sex. These programmes were highly successful. However, prostitutio
Social care of children born to HIV-infected mothers in Europe. European Collaborative Study.: AIDS Care. 1998 Feb;10(1):7-16. Unique Identifier : AIDSLINE MED/98197260; Thorne C; Newell ML; Peckham C; Department of Paediatric Epidemiology, Institute of Child Health,; London, UK. M.Newell@ich.ucl.ac.uk; Children of HIV-infected women are likely to be profoundly affected by their mothers infection, regardless of their own infection status and their number will increase with the spread of infection among women in Europe. This article describes the family circumstances and social care of 1,123 children born to HIV-infe
Safer sex and social class: findings from a study of men using the 'gay scene' in the West Midlands region of the United Kingdom.: AIDS Care. 1998 Feb;10(1):81-8. Unique Identifier : AIDSLINE MED/98197266; Hope VD; MacArthur C; Department of Public Health and Epidemiology, Medical School,; University of Birmingham, Edgbaston, UK. vhope@phls.co.uk; This article reports on associations between socio-demographic factors and safer sexual behaviour among gay and bisexual men in an English region. A cross-sectional survey using an anonymous self-complete questionnaire collected information on sexual behaviour and socio-demographic characteristics. All men using speci
Comparison of the clientele of an anonymous HIV test centre and persons tested in the general population.: AIDS Care. 1998 Feb;10(1):89-103. Unique Identifier : AIDSLINE MED/98197267; Rossi I; Jeannin A; Dubois-Arber F; Guex P; Vannotti M; Faculty of Medicine, University of Lausanne, Switzerland.; Ilario.Rossi@hospvd.ch; This study compares the clientele of a Swiss anonymous test centre with the general population tested. Information was obtained through similar questionnaires submitted to two samples of HIV-tested people aged from 17 to 45 years: the first administered in the context of a general population telephone survey (n = 245)
Construction of vectors expressing bioactive heterodimeric and single-chain murine interleukin-12 for gene therapy.: Hum Gene Ther. 1998 Mar 1;9(4):457-65. Unique Identifier : AIDSLINE MED/98184219; Lee YL; Tao MH; Chow YH; Chiang BL; Graduate Institute of Microbiology, National Taiwan University,; Taipei, Republic of China.; It has been well demonstrated that interleukin-12 (IL-12) could be useful to defend against a variety of pathogens, to suppress tumor growth and metastasis, and even to be employed as an adjuvant of vaccines to enhance beneficial type 1 T helper (Th1) cell response over detrimental type 2 T helper (Th2) cell responses
Stable integration of human immunodeficiency virus-based retroviral vectors into the chromosomes of nondividing cells.: Hum Gene Ther. 1998 Mar 1;9(4):467-75. Unique Identifier : AIDSLINE MED/98184220; Miyake K; Suzuki N; Matsuoka H; Tohyama T; Shimada T; Department of Biochemistry and Molecular Biology, Nippon Medical; School, Tokyo, Japan.; Human immunodeficiency virus type 1 (HIV-1)-based vectors are thought to be useful for gene transfer into nondividing cells. We examined whether HIV vectors can really integrate into the chromosomes of nondividing cells. CD4+HeLa cells arrested at the G2 or G1/S phase were incubated with the HIV vector pseudotyped wit
Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat.: Hum Gene Ther. 1998 Mar 1;9(4):487-96. Unique Identifier : AIDSLINE MED/98184222; Poznansky MC; Foxall R; Mhashilkar A; Coker R; Jones S; Ramstedt U; Marasco W; The Dept. of Genito-Urinary Medicine and Communicable Diseases,; Imperial College School of Medicine at St. Mary's, London, UK.; Current clinical gene therapy protocols for the treatment of human immunodeficiency virus type 1 (HIV-1) infection often involve the ex vivo transduction and expansion of CD4+ T cells derived from HIV-positive patients at a late stage in their disease (CD4 count
Expression of the human immunodeficiency virus type 1 primer binding sequence inhibits HIV-1 replication.: Hum Gene Ther. 1998 Mar 1;9(4):587-90. Unique Identifier : AIDSLINE MED/98184231; Kechli AM; Freiden PJ; Rossi JJ; Brenner MK; Choueiry MA; Garcia JV; Slobod KS; Department of Hematology/Oncology, St. Jude Children's Research; Hospital, Memphis, TN 38105, USA.; Optimal targets for anti-human immunodeficiency virus (HIV) moieties are those regions of the viral genome that are greatly conserved. The primer binding site (PBS) of HIV is an 18-nucleotide sequence complementary to the 3 end of tRNA(Lys3) that serves as the primer for HIV-1 reverse transcription. All HIV-1 isolate
Oral Candida infections--a review.: Indian J Dent Res. 1995 Jul-Sep;6(3):69-82. Unique Identifier : AIDSLINE MED/98156231; Samaranayake LP; Nair RG; Oral Biology Unit, Faculty of Dentistry, University of Hong Kong.; Candida species are the commonest agents of oral mycoses. They cause a variety of diseases including the new variant, erythematous candidosis, which is frequently described in HIV infection. Due to these and other reasons the classification of oral candidosis has been recently revised, and further more new therapeutic
Detection of HIV antibodies in saliva and its implications.: Indian J Dent Res. 1995 Jul-Sep;6(3):95-8. Unique Identifier : AIDSLINE MED/98156233; Anil S; Beena VT; Nair RG; Varghese BJ; Department of Periodontia, Dental College, Trivandrum.; Human immunodeficiency virus has been detected in almost all body fluids. With a silent disease such as HIV infection, testing for HIV antibodies currently is the most cost effective means for determining the incidence and prevalence of HIV infection in the community and for identifying HIV infection in the individual
[Primary HIV infection with esophageal candidiasis and acute toxoplasmosis (letter)]: An Med Interna. 1998 Jan;15(1):50-1. Unique Identifier : AIDSLINE MED/98182984; Mateos Rodriguez F; Fuertes Martin A; Marcos Toledano M; Jimenez Lopez A
AIDS drug scandal in South Africa continues [news]: BMJ. 1998 Mar 14;316(7134):800. Unique Identifier : AIDSLINE MED/98210616; Sidley P
Informed consent and research.: BMJ. 1998 Mar 28;316(7136):1008. Unique Identifier : AIDSLINE MED/98212323; Benatar D; Benatar SR; Department of Philosophy, University of Cape Town, Rondebosch, South; Africa dbenatar@socsci.uct.ac.za
[Evaluation of the quality of life in pediatrics: how to collect the point of view of children]: Arch Pediatr. 1997 Dec;4(12):1238-46. Unique Identifier : AIDSLINE MED/98199231; Manificat S; Dazord A; Cochat P; Nicolas J; Script Inserm et Apret 290, Lyon, France.; There are very few available child quality of life questionnaires. We describe here a French questionnaire (AUQUEI) which consists of a structured format scale (26 items). The first part of the questionnaire studies child satisfaction. Response levels are measured by checking faces expressing different emotional state
Steroid-responsive HIV optic neuropathy.: J Neuroophthalmol. 1998 Mar;18(1):25-9. Unique Identifier : AIDSLINE MED/98193714; Burton BJ; Leff AP; Plant GT; National Hospital for Neurology and Neurosurgery, London, England.; A 37-year-old man with bilateral optic neuropathy who recovered on steroid treatment is described. He was subsequently found to be human immunodeficiency virus 1 (HIV-1) positive prior to the onset of his visual symptoms, and no other cause of his optic neuropathy could be found. There is some evidence that HIV itself
Intracerebral HIV glycoprotein (gp120) enhances tumor metastasis via centrally released interleukin-1.: Brain Res. 1998 Jan 19;781(1-2):244-51. Unique Identifier : AIDSLINE MED/98176052; Hodgson DM; Yirmiya R; Chiappelli F; Taylor AN; Dept. of Neurobiology and Brain Research Institute, School of; Medicine, University of California, Los Angeles, CA 90095, USA.; hodgson@psych.ucla.edu; Infection with the human immunodeficiency virus (HIV) is associated with a high incidence of cancers. This relationship does not appear to be due to a direct effect of the virus, and may be mediated by neuroimmune interactions since the HIV glycoprotein, gp120, enters the brain soon after infection with HIV, and intra
Capture of an early fusion-active conformation of HIV-1 gp41.: Nat Struct Biol. 1998 Apr;5(4):276-9. Unique Identifier : AIDSLINE MED/98206292; Furuta RA; Wild CT; Weng Y; Weiss CD; Office of Vaccines, Center for Biologics Evaluation and Research, Food; and Drug Administration, Bethesda, Maryland 20892-4555, USA.; Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformat
Protease inhibitors for the treatment of human immunodeficiency virus infection.: Am J Health Syst Pharm. 1998 Feb 1;55(3):233-54. Unique Identifier : AIDSLINE MED/98151218; Kakuda TN; Struble KA; Piscitelli SC; Division of Clinical Pharmacology, University of Minnesota Academic; Health Center, Minneapolis, USA.; The pharmacology, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage and administration of protease inhibitors are reviewed. Protease inhibitors are a novel class of drugs used for the treatment of human immunodeficiency virus HIV) infection.
Preventing and treating azole-resistant oropharyngeal candidiasis in HIV-infected patients.: Am J Health Syst Pharm. 1998 Feb 1;55(3):279-83. Unique Identifier : AIDSLINE MED/98151224; Penzak SR; Gubbins PO; Department of Pharmacy Practice, College of Pharmacy, University of; Arkansas for Medical Sciences, Little Rock 72205-7122, USA.
Use of nonnucleoside reverse-transcriptase inhibitors.: Am J Health Syst Pharm. 1998 Feb 1;55(3):283-7. Unique Identifier : AIDSLINE MED/98151225; Holtzer CD; Coleman RL; UCSF AIDS Program, San Francisco General Hospital, CA 94110, USA.; choltzer@sfaids.ucsf.edu
Anonymous anti-HIV agent [editorial]: Nat Med. 1998 Apr;4(4):371. Unique Identifier : AIDSLINE MED/98206841
Indian state plans compulsory HIV testing, segregation and branding [news]: Nat Med. 1998 Apr;4(4):378. Unique Identifier : AIDSLINE MED/98206848; Jayaraman KS
Tipping the scales of herpes simplex virus reactivation: the important responses are local.: Nat Med. 1998 Apr;4(4):381-2. Unique Identifier : AIDSLINE MED/98206850; Posavad CM; Koelle DM; Corey L; Department of Laboratory Medicine, Univ. of Washington, Seattle 98104,; USA.
Mother knows best [news; comment]: Nat Med. 1998 Apr;4(4):390-1. Unique Identifier : AIDSLINE MED/98206855; Scadden DT
Retroviral zoonoses [news; comment]: Nat Med. 1998 Apr;4(4):391-2. Unique Identifier : AIDSLINE MED/98206856; Weiss RA
Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara.: Nat Med. 1998 Apr;4(4):397-402. Unique Identifier : AIDSLINE MED/98206860; Schneider J; Gilbert SC; Blanchard TJ; Hanke T; Robson KJ; Hannan CM; Becker M; Sinden R; Smith GL; Hill AV; Institute of Molecular Medicine, Nuffield Department of Medicine,; University of Oxford, John Radcliffe Hospital, UK.; joerg.schneider@ndm.ox.ac.uk; Immunization with irradiated sporozoites can protect against malaria infection and intensive efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting of single dose priming with plasmid DNA followe
Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination.: Nat Med. 1998 Apr;4(4):421-7. Unique Identifier : AIDSLINE MED/98206864; Cheynier R; Gratton S; Halloran M; Stahmer I; Letvin NL; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris.; The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCG inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV varia
Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease [see comments]: Nat Med. 1998 Apr;4(4):428-34. Unique Identifier : AIDSLINE MED/98206865; Lunardi-Iskandar Y; Bryant JL; Blattner WA; Hung CL; Flamand L; Gill P; Hermans P; Birken S; Gallo RC; Institute of Human Virology, University of Maryland, Baltimore; 21201-1192, USA.; The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi s sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factors is not due to the native hCG heterodimer, including
Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus.: Nat Med. 1998 Apr;4(4):435-40. Unique Identifier : AIDSLINE MED/98206866; Lee H; Veazey R; Williams K; Li M; Guo J; Neipel F; Fleckenstein B; Lackner A; Desrosiers RC; Jung JU; New England Regional Primate Research Center, Harvard Medical School,; Southborough, MA 01772-9102, USA.; At a position equivalent to the gene encoding the saimiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi s sarcoma-associated herpesvirus (KSHV) contains a distinct open reading frame called K1. Although KSHV and HVS are related members of the rhadinovirus subgroup of gamma herpesviruses, K1 and STP e
Novel role of human CD4 molecule identified in neurodegeneration.: Nat Med. 1998 Apr;4(4):441-6. Unique Identifier : AIDSLINE MED/98206867; Buttini M; Westland CE; Masliah E; Yafeh AM; Wyss-Coray T; Mucke L; Department of Neurology, University of California, San Francisco; 94141-9100, USA.; The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peri
In vitro antiviral activity on dengue virus of marine natural products.: Cell Mol Life Sci. 1998 Feb;54(2):167-70. Unique Identifier : AIDSLINE MED/98200779; Laille M; Gerald F; Debitus C; Institut Pasteur, Noumea (New Caledonia). laille@pasteur.nc; Metabolites isolated from marine invertebrates, callipeltin A, crambescidin, ptilomycalin A, celeromycalin, gymnochrome B, gymnochrome D and isogymnochrome D previously shown bioactive on either herpes simplex virus 1 or human immunodeficiency virus, were tested on a new in vitro bioassay using the dengue virus 1. Onl
Immunologic features of tumor-infiltrating lymphocytes and peripheral blood lymphocytes in ovarian cancer patients.: J Soc Gynecol Investig. 1998 Mar-Apr;5(2):102-7. Unique Identifier : AIDSLINE MED/98170128; Schondorf T; Engel H; Kurbacher CM; Brenne U; Kolhagen H; Gohring UJ; Scharl A; Mallmann P; Department of Gynecology and Obstetrics, University of Cologne,; Germany.; OBJECTIVE: To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with ovarian cancer in order to detect specific antitumor-reactive-immunocompetent cells. METHODS: Tumor infiltrating lymphocytes and PBL
Molecular detection and isolation of human T-cell lymphotropic virus type I (HTLV-I) from patients with HAM/TSP in Sao Paulo, Brazil.: Clin Diagn Virol. 1998 Jan;9(1):17-23. Unique Identifier : AIDSLINE MED/98223947; Segurado AA; Domingues RB; Muniz MR; Fink MC; Marchiori PE; Scaff M; Lal RB; Department of Infectious Diseases, School of Medicine, University of; Sao Paulo, Brazil. segurado@usp.br; BACKGROUND: Infection with HTLV-I is etiologically linked with HTLV-I-associated myelopathy/tropical spastic paraparesis HAM/TSP). However some patients with chronic progressive paraparesis resembling HAM/TSP have been shown to be infected with HTLV-II. OBJECTIVE: To clarify the role of each of these human retroviruse
Introduction of HIV-1 subtypes C, E and A into Austria.: Clin Diagn Virol. 1998 Jan;9(1):25-8. Unique Identifier : AIDSLINE MED/98223948; Puchhammer-Stockl E; Kunz C; Faatz E; Kasper P; Heinz FX; Institute of Virology, University of Vienna, Austria.; BACKGROUND: Different subtypes of HIV-1 are prevalent in various geographical regions. Knowledge of their distribution is of importance with respect to possible differences in biological properties (such as reported for subtype E) as well as to diagnostic problems that may arise when specific subtypes are not recogniz
Prevalence of infection with HIV, hepatitis B and C viruses, in four high risk groups in Eritrea.: Clin Diagn Virol. 1998 Jan;9(1):29-35. Unique Identifier : AIDSLINE MED/98223949; Ghebrekidan H; Cox S; Wahren B; Grandien M; Department of Virology, Swedish Institute for Infectious Disease; Control, Karolinska Institute, Stockholm, Sweden.; BACKGROUND: Little is known about the prevalence of infections in different population groups in Africa, and about the influence of living conditions on the spread of infections. This study is the first of its kind in the state of Eritrea and is expected to serve as an evaluation
Liposomal doxorubicin in pulmonary Kaposi's sarcoma: improved survival as compared to patients without liposomal doxorubicin.: Eur J Med Res. 1998 Feb 21;3(1-2):13-9. Unique Identifier : AIDSLINE MED/98174147; Grunaug M; Bogner JR; Loch O; Goebel FD; Medizinische Poliklinik, Ludwig-Maximilians-University, Munich,; Germany.; OBJECTIVE: Pulmonary Kaposi s sarcoma (KS) in HIV-infected patients is characterised by a poor prognosis with a mean survival time of 2 to 6 months. Our goal was to evaluate survival in patients with pulmonary KS treated with Stealth liposomal doxorubicin (SL-DOX) and to compare it with patients without SL-DOX therapy
Neurobehavioral functioning in asymptomatic HIV-1 infected women.: J Int Neuropsychol Soc. 1998 Mar;4(2):172-8. Unique Identifier : AIDSLINE MED/98190732; Stern RA; Arruda JE; Somerville JA; Cohen RA; Boland RJ; Stein MD; Martin EM; Brown University School of Medicine, Providence, RI, USA.; rstern@lifespan.org; Numerous reports have assessed the neuropsychological functioning of medically asymptomatic HIV-1 infected men. However, to date there have been no published studies of the neuropsychological functioning of asymptomatic HIV-1 infected women, even though women represent the fastest-growing demographic group of HIV-1 in
Chemotherapeutic agents for human immunodeficiency virus infection: mechanism of action, pharmacokinetics, metabolism, and adverse reactions.: Clin Ther. 1998 Jan-Feb;20(1):2-25; discussion l. Unique Identifier : AIDSLINE MED/98182568; Beach JW; Department of Pharmaceutical and Biomedical Sciences, College of; Pharmacy, University of Georgia, Athens, USA.; Since the mid-1980s, four new nucleoside reverse transcriptase RT) inhibitors (zalcitabine, didanosine, stavudine , and lamivudine), two nonnucleoside RT inhibitors ( nevirapine and
Oropharyngeal candidiasis: a review of its clinical spectrum and current therapies.: Clin Ther. 1998 Jan-Feb;20(1):40-57. Unique Identifier : AIDSLINE MED/98182570; Epstein JB; Polsky B; Department of Dentistry, Vancouver Hospital & Health Sciences Center,; British Columbia.; With the increased use of antibiotics and immunosuppressive agents, oropharyngeal candidiasis is becoming more common. This infection is also associated with such advances in medical management as chemotherapy and organ transplantation and with human immunodeficiency virus infection. Various topical and systemic agent
Reaching seriously at-risk populations: health interventions in criminal justice settings.: Health Educ Behav. 1998 Feb;25(1):99-120. Unique Identifier : AIDSLINE MED/98134843; Hammett TM; Gaiter JL; Crawford C; Abt Associates, Inc., Cambridge, MA 02138-1168, USA.; ted_hammett@abtassoc.com; More than 6 million people are under some form of criminal justice supervision in the United States on any given day. The vast majority are arrested in and return to urban, low-income communities. These are men, women, and adolescents with high rates of infectious diseases such as HIV/
A study of chest infections in HIV seropositive patients in Kuala Lumpur.: Int J Clin Pract. 1998 Jan-Feb;52(1):23-6. Unique Identifier : AIDSLINE MED/98197628; Wood E; Cheong I; Lee C; Department of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur,; Malaysia.; A retrospective study of 144 adults with HIV infection was conducted to investigate the prevalence of upper and lower respiratory tract infections (URTIs and LRTIs). The patients were divided into two groups: those with acquired HIV through intravenous drug abuse (IVDA), and those who had acquired HIV through other
Host and viral factors influencing heterosexual HIV transmission.: Rev Reprod. 1998 Jan;3(1):42-51. Unique Identifier : AIDSLINE MED/98168806; Miller CJ; California Regional Primate Research Center and Department of; Pathology, Microbiology and Immunology, School of Veterinary Medicine,; University of California, Davis 95616, USA.; The World Health Organization estimates that 28-30 million people have been infected with human immunodeficiency virus (HIV). Although many important questions remain, much has been learned regarding the biology of heterosexual HIV transmission. For example, most sexual transmission of
Optima: a windows-based program for computer-aided optimization of controlled-release dosage forms.: Pharm Dev Technol. 1996 Dec;1(4):405-14. Unique Identifier : AIDSLINE MED/98177749; Lu DR; Abu-Izza K; Chen W; Department of Pharmaceutics, College of Pharmacy, University of; Georgia, Athens 30602, USA. rlu@merc.rx.uga.edu; The purpose of this work was to develop a computer program that assists optimization of controlled-release devices, both visually and mathematically, using response surface methodology (RSM). A Windows-based computer program, Optima, which interactively implemented a number of subroutines for the optimization procedur
Topical lithium succinate ointment (Efalith) in the treatment of AIDS-related seborrhoeic dermatitis.: Clin Exp Dermatol. 1997 Sep;22(5):216-9. Unique Identifier : AIDSLINE MED/98197605; Langtry JA; Rowland Payne CM; Staughton RC; Stewart JC; Horrobin DF; Department of Dermatology, Westminster Hospital, London, UK.; A randomised, double-blind, placebo-controlled trial with lithium succinate ointment was conducted in patients with AIDS-associated facial seborrhoeic dermatitis. Twice daily applications of the ointment brought about a rapid (2.5 days) and highly significant P = 0.007) improvement in the severity of the condition. Li
Erythema elevatum diutinum and AIDS: are they related? [letter]: Clin Exp Dermatol. 1997 Sep;22(5):250-1. Unique Identifier : AIDSLINE MED/98197615; Revenga F; Vera A; Munoz A; De la Llana FG; Alejo M; Rodriguez-Peralto JL
Relation between hospital HIV/AIDS caseload and mortality among persons with HIV/AIDS in Canada.: Clin Invest Med. 1998 Feb;21(1):27-32. Unique Identifier : AIDSLINE MED/98174066; Hogg RS; Raboud J; Bigham M; Montaner JS; O'Shaughnessy M; Schechter MT; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's; Hospital.; OBJECTIVE: To assess the relation between HIV/AIDS hospital caseload and mortality in Canada . DESIGN: Descriptive, population-based study. SETTING: All hospitals in Canada that admitted any patients with HIV or AIDS between Mar. 31, 1987, and Apr. 1, 1994. PATIENTS: All patients wi
[Strongyloides stercoralis infection in a patient with AIDS and non-Hodgkin lymphoma]: Dtsch Med Wochenschr. 1998 Mar 27;123(13):381-5. Unique Identifier : AIDSLINE MED/98217439; Muller A; Fatkenheuer G; Salzberger B; Schrappe M; Diehl V; Franzen C; Klinik I fur Innere Medizin, Universitat zu Koln.; HISTORY AND CLINICAL FINDINGS: The patient, now 50 years old, an immigrant miner from the former Yugoslavia who was known to have AIDS, was in 1992 found to have non-Hodgkin lymphoma of the oesophagus and given five cycles of multiple chemotherapy (CHOP) with complete remission. Subsequently he complained of retroster
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly.: EMBO J. 1998 Mar 16;17(6):1555-68. Unique Identifier : AIDSLINE MED/98169372; von Schwedler UK; Stemmler TL; Klishko VY; Li S; Albertine KH; Davis DR; Sundquist WI; Department of Biochemistry, University of Utah, Salt Lake City, UT; 84132, USA.; After budding, the human immunodeficiency virus (HIV) must mature into an infectious viral particle. Viral maturation requires proteolytic processing of the Gag polyprotein at the matrix-capsid junction, which liberates the capsid (CA) domain to condense from the spherical protein coat of the immature virus into the
Cooperative interaction of ets-1 with USF-1 required for HIV-1 enhancer activity in T cells.: EMBO J. 1998 Mar 16;17(6):1728-39. Unique Identifier : AIDSLINE MED/98169389; Sieweke MH; Tekotte H; Jarosch U; Graf T; EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.; The distal enhancer region of the human immunodeficiency virus 1 HIV-1) long terminal repeat (LTR) is known to be essential for HIV replication and to contain immediately adjacent E-box and Ets binding sites. Based on a yeast one-hybrid screen we have identified the E-box binding protein USF-1 as a direct interaction
Cytomegalovirus retinitis in patients with AIDS in Europe. AIDS in Europe Study Group.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):876-82. Unique Identifier : AIDSLINE MED/98155055; Burke M; Yust I; Katlama C; Vardinon N; Clumeck N; Pinching AJ; Ledergerber B; Gatell JM; Chiesi A; Barton SE; Lundgren JD; Pedersen C; Department of Medicine A and Clinical Immunology, Ichilov Hospital,; Tel Aviv, Israel.; The incidence of cytomegalovirus ( CMV ) retinitis and risk factors associated with the condition were studied in patients with the acquired immune deficiency syndrome (AIDS) in a multicenter retrospective cohort study of 6458
Visceral leishmaniasis in patients infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):898-903. Unique Identifier : AIDSLINE MED/98155058; Laguna F; Adrados M; Alvar J; Soriano V; Valencia ME; Moreno V; Polo R; Verdejo J; Jimenez MI; Martinez P; Martinez ML; Gonzalez-Lahoz JM; Servicio de Enfermedades Infecciosas, Centro Nacional de Investigacion; Clinica, Instituto de Salud Carlos III, Madrid, Spain.; The experience with 52 episodes of visceral leishmaniasis diagnosed in 43 patients is reported. The most common symptoms were fever (81%), splenomegaly (65%), hepatomegaly (63%), and pancytopenia (73%). In 79% of the patients, CD4+ cell counts were
Influence of hepatitis G virus infection on liver disease.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):916-9. Unique Identifier : AIDSLINE MED/98155061; Diamantis ID; Kouroumalis E; Koulentaki M; Fasler-Kan E; Schmid PA; Hirsch HH; Buhler H; Gyr K; Battegay M; Outpatient Department of Internal Medicine, University Hospital Basel,; Switzerland.; The influence of hepatitis G virus (HGV) infection on disease activity in hepatitis C related and unrelated liver disease was investigated in 254 individuals using an EIA polymerase chain reaction assay for HGV. One hundred patients had chronic hepatitis C, 26 primary biliary cirrhosis, and 30 alcoholic liver cirrhosi
Bacteremia and respiratory involvement by Alcaligenes xylosoxidans in patients infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):933-8. Unique Identifier : AIDSLINE MED/98155065; Manfredi R; Nanetti A; Ferri M; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universita di Bologna, Italy.; Seven cases of Alcaligenes xylosoxidans bacteremia and/or respiratory disease in patients infected with the human immunodeficiency virus (HIV) are described. Reported only thrice previously in this setting, these bacterial complications occurred during different phases of HIV infection and were associated with leukope
Pneumocystis carinii meningoradiculitis in a patient with AIDS.: Eur J Clin Microbiol Infect Dis. 1997 Dec;16(12):940-2. Unique Identifier : AIDSLINE MED/98155067; Villanueva JL; Cordero E; Caballero-Granado FJ; Regordan C; Becerril B; Pachon J; Infectious Disease Unit and Service of Microbiology, Hospital; Universitario Virgen del Rocio, Seville, Spain.; Pneumocystis carinii is a common opportunistic pathogen in patients infected with the human immunodeficiency virus (HIV). Pneumocystis carinii pneumonia is common, while extrapulmonary infections with Pneumocystis carinii have been reported sparingly. The clinical features are frequently nonspecific. The detection of
Thyroid abscess due to Rhodococcus equi in a patient infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):55-7. Unique Identifier : AIDSLINE MED/98171138; Martin-Davila P; Quereda C; Rodriguez H; Navas E; Fortun J; Meseguer M; Moreno A; Guerrero A; Department of Microbiology, Hospital Ramon y Cajal, Madrid, Spain.; A case of thyroid abscess due to Rhodococcus equi in an HIV-positive patient with previous pulmonary abscess is reported. Rhodococcus equi is a gram-positive rod that can cause infections in both immunocompetent and immunocompromised patients, though it occurs more frequently in patients with dysfunctional cellular im
Raynaud's phenomenon and acral necrosis after chemotherapy for AIDS-related Kaposi's sarcoma.: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):58-60. Unique Identifier : AIDSLINE MED/98171139; Reiser M; Bruns C; Hartmann P; Salzberger B; Diehl V; Fatkenheuer G; Medizinische Klinik I, University Hospital, Cologne, Germany.; Raynaud s phenomenon is a common vascular side effect of chemotherapy drug regimens. Chemotherapy-induced Raynaud s phenomenon leading to acral gangrene has rarely been reported. In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi s sarcom
Frequent chronic hepatitis B virus infection in HIV-infected patients positive for antibody to hepatitis B core antigen only. Swiss HIV Cohort Study.: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):6-13. Unique Identifier : AIDSLINE MED/98171127; Hofer M; Joller-Jemelka HI; Grob PJ; Luthy R; Opravil M; Division of Infectious Diseases and Hospital Epidemiology, University; Hospital, Zurich, Switzerland.; Persons with immune deficiency may present with atypical results in serological tests for hepatitis B virus (HBV). Frozen serum specimens that were sequentially obtained over time from a cohort of 57 HIV-infected patients, all of whom tested positive only for antibody to hepatitis B core antigen (anti-HBcAg), were the
First isolation in Europe of Legionella feeleii from two cases of pneumonia [letter]: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):64-6. Unique Identifier : AIDSLINE MED/98171142; Lo Presti F; Riffard S; Neyret C; Celard M; Vandenesch F; Etienne J
Expression of dipeptidylaminopeptidase IV/CD26 in peripheral blood lymphocytes of hemophilic subjects.: Eur J Haematol. 1998 Mar;60(3):145-52. Unique Identifier : AIDSLINE MED/98208190; Invernizzi R; Montani N; Giusto M; Mosconi E; Lorenzutti F; Comolli G; Pecci A; Gamba G; Department of Internal Medicine, University of Pavia, Italy.; CD26 antigen, a 110 kDa membrane glycoprotein with exopeptidase activity (DAP IV), is an activation marker of T lymphocytes preferentially expressed on CD4+ memory cells and involved in T cell proliferation and IL-2 production after antigenic stimulation. We employed c
Modulatory function on autologous myeloid progenitor cells of clonal T-lymphocytes following autologous bone marrow transplantation.: Eur J Haematol. 1998 Mar;60(3):189-96. Unique Identifier : AIDSLINE MED/98208196; Hokland P; Carlsen I; Hokland M; Nielsen B; Department of Haematology, Aarhus University Hospital, Denmark.; hokland@gjallar.daimi.aau.dk; We have studied the regulatory capacity of clonal T-lymphocytes from patients undergoing autologous bone marrow transplantation ABMT) on the generation of CFU-GM from their harvest marrow preparations. To this end, T-lymphocytes from peripheral blood from 5 patients undergoing ABMT isolated 10 d before and 7, 14 and 2
Letting minors consent to HIV tests.: Fam Plann Perspect. 1998 Jan-Feb;30(1):2. Unique Identifier : AIDSLINE MED/98155909
Inching toward HIV goals.: Fam Plann Perspect. 1998 Jan-Feb;30(1):2-3. Unique Identifier : AIDSLINE MED/98155910
Does the pill help spread HIV?: Fam Plann Perspect. 1998 Jan-Feb;30(1):3. Unique Identifier : AIDSLINE MED/98155911
[AIDS: when a nightmare becomes controllable... (news)]: Fortschr Med. 1998 Jan 30;116(3):10-1. Unique Identifier : AIDSLINE MED/98183017
[Safer sex--do new therapies promote risk taking? (interview)]: Fortschr Med. 1998 Jan 30;116(3):11-2. Unique Identifier : AIDSLINE MED/98183018; Zippel S; Dermatologischen Klinik und Poliklinik, Munchen.
[Effects of physical exhaustion on immune systems]: Hokkaido Igaku Zasshi. 1998 Jan;73(1):61-71. Unique Identifier : AIDSLINE MED/98207815; Takahashi K; Department of Hygiene and Preventive Medicine, Hokkaido University; School of Medicine, Sapporo, Japan.; The present study was performed to elucidate the effects of physical fatigue on immune parameters of peripheral blood and splenic T cells in rats. Male Wistar rats aged 20 to 45 weeks were used for the experiment. Swimming was employed as a physical fatigue load. The rats in the single-load group with a weight equal t
Systematic method for determining intravenous drug treatment strategies aiding the humoral immune response.: IEEE Trans Biomed Eng. 1998 Apr;45(4):429-39. Unique Identifier : AIDSLINE MED/98217708; Rundell AE; DeCarlo R; Balakrishnan V; HogenEsch H; School of Electrical and Computer Engineering, Purdue University, West; Lafayette, IN 47906, USA. rundell@ecn.purdue.edu; This paper delineates a systematic method for determining optimal intravenous drug delivery strategies for patients having illnesses that primarily evoke a humoral immune response and are treatable by antibiotics. The method derives from a nonlinear, distributed predator-prey model that captures the dominant antigen
A common immunological epitope existing between HIV-1 gp41 and human interferon-alpha and -beta.: Immunobiology. 1998 Feb;198(4):333-42. Unique Identifier : AIDSLINE MED/98223953; Chen YH; Dierich MP; Department of Biological Science and Biotechnology, Tsinghua; University, Beijing, China.; Based on the similar effects that HIV-1 gp41 like human type I interferons (IFN-alpha and -beta) upregulated MHC expression and inhibited lymphocyte proliferation, we compared amino acid sequences of gp41 and human type I interferons (IFN-alpha and beta), and found sequence-similarity existing between the immunosuppre
Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients.: Immunobiology. 1998 Feb;198(4):485-8. Unique Identifier : AIDSLINE MED/98223965; Malo A; Rommel F; Bogner J; Gruber R; Schramm W; Goebel FD; Riethmuller G; Wank R; Institut fur Immunologie, Universitat Munchen, Germany.; The CCR5 chemokine receptor is an important coreceptor for macrophage-tropic HIV strains. Homozygous carriers of the mutated CCR5 receptor with a 32 bp deletion (delta 32-CCR5) are highly protected against HIV infection. A protective effect has also been described for heterozygous individuals carrying both mutated and
Perinatal transmission of HIV and diagnosis of HIV infection in infants: a review.: Ir J Med Sci. 1998 Jan-Mar;167(1):28-32. Unique Identifier : AIDSLINE MED/98201119; Nourse CB; Butler KM; Department of Paediatrics, University College Dublin, Crumlin, Dublin.; Paediatric HIV infection has become a major burden on families, communities and health services worldwide. The vast majority of children now acquire HIV as a result of mother to infant vertical) transmission. Recent major advances have occurred following the greater understanding of the risk factors for perinatal tran
Cyclin D1 overexpression detected by a simple competitive reverse transcription-polymerase chain reaction assay for lymphoid malignancies.: Jpn J Cancer Res. 1998 Feb;89(2):159-66. Unique Identifier : AIDSLINE MED/98208222; Taniguchi T; Fujita A; Takahashi S; Uchimaru K; Yoshikawa M; Asano S; Fujita T; Motokura T; Fourth Department of Internal Medicine, University of Tokyo, School of; Medicine.; t(11;14)(q13;q32) observed in B-cell malignancies is associated with cyclin D1 (bcl-1, PRAD1, CCND1) overexpression. We devised a simple competitive reverse transcription-polymerase chain reaction (RT-PCR) assay for rapid detection of cyclin D1 overexpression. Sharing a single upstream primer derived from a homologous
Management of the orthopaedic complications of haemophilia [editorial]: J Bone Joint Surg Br. 1998 Mar;80(2):191-6. Unique Identifier : AIDSLINE MED/98206518; Rodriguez-Merchan EC
Identification of biological activity profiles using substructural analysis and genetic algorithms.: J Chem Inf Comput Sci. 1998 Mar-Apr;38(2):165-79. Unique Identifier : AIDSLINE MED/98199332; Gillet VJ; Willett P; Bradshaw J; Department of Information Studies, University of Sheffield, Western; Bank, United Kingdom. V.GILLET@SHEFFIELD.AC.UK; A substructural analysis approach is used to calculate biological activity profiles, which contain weights that describe the differential occurrences of generic features (specifically, the numbers of hydrogen-bond donors and acceptors, the numbers of rotatable bonds and aromatic rings, the molecular weights, and the 2
Determination of HCV RNA concentration by direct quantitation of the products from a single RT-PCR.: J Virol Methods. 1997 Dec;69(1-2):113-24. Unique Identifier : AIDSLINE MED/98163285; Perez-Ruiz M; Torres C; Garcia-Lopez PA; Ruiz-Extremera A; Salmeron J; Berzal-Herranz A; Instituto de Parasitologia y Biomedicina Lopez Neyra CSIC, Hospital; Clinico Universitario, Granada, Spain.; A novel method for the estimation of HCV RNA levels in vivo was developed, based on competitive RT-PCR. The use of the Tth DNA polymerase and 5 32P-labeled antisense primer respectively reduced cross-contamination and permitted the direct quantification of viral loads by the analysis of the radioactivity of PCR produ
Semi-quantitative detection of cytomegalovirus DNA from native serum and plasma by nested PCR: influence of DNA extraction procedures.: J Virol Methods. 1997 Dec;69(1-2):125-35. Unique Identifier : AIDSLINE MED/98163286; Hamprecht K; Mikeler E; Jahn G; Abt. Medizinische Virologie und Epidemiologie der Viruskrankheiten,; Hygiene-Institut der Universitat Tubingen, Germany.; klaus.hamprecht@uni-tuebingen.de; The diagnostic implications of different procedures of DNA extraction were examined for the detection of HCMV DNA from sera and plasma of immunosuppressed patients. The detection limit of HCMV plasmid DNA from cell free seronegative plasma and serum by limiting dilution nested PCR decreased in the following sequence:
Quantification of HIV-1 proviral DNA from peripheral blood mononuclear cells using a high throughput four-competitor competitive PCR.: J Virol Methods. 1997 Dec;69(1-2):171-80. Unique Identifier : AIDSLINE MED/98163290; Comandini UV; Sonnerborg A; Vahlne A; Yun Z; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institute, Huddinge Hospital, Sweden.; A multiple competitor PCR (mcPCR) was developed to quantify HIV-1 proviral DNA from peripheral blood mononuclear cells (PBMC). DNA extracted from a mixture of HIV infected PBMC and four size-mutated DNA competitors were co-amplified. The Cy5-fluorescence labelled PCR products were denatured by heating, separated using
Quantification of hepatitis B virus DNA using competitive PCR and a scintillation proximity assay.: J Virol Methods. 1997 Dec;69(1-2):197-208. Unique Identifier : AIDSLINE MED/98163293; Simpson PR; Yu XH; Redza ZM; Anson JG; Chan SH; Lin Y; Scitech Genetics Ltd., The Maxwell, Singapore, Singapore.; A rapid assay for the quantification of hepatitis B virus DNA in human serum was developed. The principle of the method combines competitive polymerase chain reaction (cPCR) (for the controlled amplification of hepatitis B virus DNA) and scintillation proximity assay (SPA) technology (for rapid detection and quantitat
HPV 16 DNA and mRNA in cervical brush samples quantified by PCR and microwell hybridization.: J Virol Methods. 1997 Dec;69(1-2):209-22. Unique Identifier : AIDSLINE MED/98163294; Forslund O; Lindqvist P; Haadem K; Czegledy J; Hansson BG; Clinical Virology Section, Department of Medical Microbiology, Malmo,; Sweden. Ola.Forslund@mikrobiol.mas.lu.se; To quantitate HPV 16 DNA and mRNA, biotinylated amplicons from PCR and reverse transcription PCR were captured on streptavidin-coated microtitre plates. The amount of amplicon was determined by colorimetric detection after hybridization with an alkaline phosphatase-labelled probe. Dynamic ranges of between 4 and 6 log
Reactivity of a new HIV-1 group O third generation A-HIV-1/-2 assay with an unusual HIV-1 seroconversion panel and HIV-1 group O/group M subtyped samples.: J Virol Methods. 1997 Dec;69(1-2):29-37. Unique Identifier : AIDSLINE MED/98163276; van Binsbergen J; Keur W; v.d. Graaf M; Siebelink A; Jacobs A; de Rijk D; Toonen J; Zekeng L; Afane Ze E; Gurtler LG; Organon Teknika, Boxtel, The Netherlands.; It was shown previously that about 97% of the anti-HIV-1 group O strain-positive samples were detected by crossreaction with native HIV-1 gp160 (Van Binsbergen et al., Evaluation of a new third generation anti-HIV-1/anti-HIV-2 assay with increased sensitivity for HIV-1 group O, J. Virol. Methods 60 (1996) 131-137). Fo
Genetic subtyping and epidemiological study of feline immunodeficiency virus by nested polymerase chain reaction-restriction fragment length polymorphism analysis of the gag gene.: J Virol Methods. 1998 Jan;70(1):107-11. Unique Identifier : AIDSLINE MED/98165664; Hohdatsu T; Motokawa K; Usami M; Amioka M; Okada S; Koyama H; Department of Veterinary Infectious Diseases, School of Veterinary; Medicine and Animal Sciences, Kitasato University, Towada, Aomori,; Japan. hohdatsu@vmas.kitasato-u.ac.jp; Genetic subtyping of feline immunodeficiency virus (FIV) was carried out by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. A 329-base pair fragment in the FIV gag gene was amplified by nested PCR, then digested with restriction enzymes, HindIII, PvuII and BamHI. Using the
Safety factors involved in the extraction of biologically active proteins from human immunodeficiency virus.: J Virol Methods. 1998 Jan;70(1):113-5. Unique Identifier : AIDSLINE MED/98165665; White EL; Bowdon BJ; Shannon WM; Southern Research Institute, Birmingham, AL 35205, USA. white@sri.org; The disruption of the viral coat of human immunodeficiency virus by Triton X-100, a nonionic detergent, is a time-dependent process which requires incubation times of 30 min or longer. Conditions for the production of a noninfectious sample from a viral pellet that can be used to measure reverse transcriptase activity
A recombinant protein based immunoassay for the combined detection of antibodies to HIV-1, HIV-2 and HTLV-I.: J Virol Methods. 1998 Jan;70(1):85-91. Unique Identifier : AIDSLINE MED/98165661; Benitez J; Palenzuela D; Rivero J; Gavilondo JV; Immunotechnology and Diagnostics Division, Center for Genetic; Engineering and Biotechnology, Havana, Cuba.; Lab.diagnostico@cigb.edu.cu; The aim of this study was to develop and evaluate a combined assay for the detection of antibodies to HIV-1, HIV-2 and HTLV-I human T-cell leukemia virus type I). A mixture of recombinant proteins and synthetic peptides was fixed to the surface of microELISA wells and a protein A peroxidase conjugate was used as trace
Characterization of endometrial T lymphocyte subpopulations in spontaneous early pregnancy loss.: Hum Reprod. 1998 Jan;13(1):44-7. Unique Identifier : AIDSLINE MED/98171179; Vassiliadou N; Bulmer JN; Department of Pathology, University of Newcastle, Royal Victoria; Infirmary, Newcastle upon Tyne, UK.; T lymphocyte subpopulations were compared in normal first trimester human decidua and in decidua associated with spontaneous abortion. Cryostat sections were labelled using a panel of monoclonal antibodies specific for CD3, CD8, CD4 and for the alphabeta and gammadelta heterodimers of the T cell receptor using an avid
Clinical comparison of an enhanced-sensitivity branched-DNA assay and reverse transcription-PCR for quantitation of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1998 Mar;36(3):716-20. Unique Identifier : AIDSLINE MED/98167726; Nolte FS; Boysza J; Thurmond C; Clark WS; Lennox JL; Department of Pathology, Emory University School of Medicine, Atlanta,; Georgia 30322, USA. fnolte@emory.edu; The performance characteristics of an enhanced-sensitivity branched-DNA assay (bDNA) (Quantiplex HIV-1 version 2.0; Chiron Corp., Emeryville, Calif.) and a reverse transcription (RT)-PCR assay (AMPLICOR HIV-1 Monitor; Roche Diagnostic Systems, Inc., Branchburg, N.J.) were compared in a molecular diagnostic laboratory.
Highly sensitive method for amplification of human immunodeficiency virus type 2 DNA.: J Clin Microbiol. 1998 Mar;36(3):809-11. Unique Identifier : AIDSLINE MED/98167743; Damond F; Loussert-Ajaka I; Apetrei C; Descamps D; Souquiere S; Lepretre A; Matheron S; Brun-Vezinet F; Simon F; Laboratoire de Virologie, Hopital Bichat-Claude Bernard, Paris,; France.; We evaluated a new human immunodeficiency virus type 2 (HIV-2) DNA amplification strategy based on peripheral blood mononuclear cell long PCR (XL PCR) followed by nested PCR amplification. The primers used were located in the highly conserved long terminal repeat and in the pol regions of the genome. Five primer pairs
Intra-assay performance characteristics of five assays for quantification of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1998 Mar;36(3):835-9. Unique Identifier : AIDSLINE MED/98167752; Lin HJ; Pedneault L; Hollinger FB; Division of Molecular Virology, Baylor College of Medicine, Houston,; Texas 77030, USA.; Three kits (Roche AMPLICOR human immunodeficiency virus type 1 [HIV-1] Monitor, Chiron enhanced-sensitivity bDNA, and Organon Teknika NASBA HIV-1 QT) and two in-house assays (from National Genetics Institute and Baylor College of Medicine) were compared with a blinded panel. The results were evaluated as to intra-assa
Detection and direct typing of herpes simplex virus in perianal ulcers of patients with AIDS by PCR.: J Clin Microbiol. 1998 Mar;36(3):848-9. Unique Identifier : AIDSLINE MED/98167756; do Nascimento MC; Sumita LM; de Souza VA; Pannuti CS; Instituto de Infectologia Emilio Ribas, Sao Paulo, SP, Brazil.; The presence of herpes simplex virus type 1 (HSV-1) and HSV-2 in perianal ulcerations of 41 AIDS patients was assessed by virus culture and a type-specific PCR-based assay. HSV was isolated from the lesion site in 24 of 41 (58.5%) patients, and HSV DNA was detected by PCR in all 24 (100%) of these specimens. Additiona
Stability of free and complexed human immunodeficiency virus p24 antigens during storage for various intervals [letter]: J Clin Microbiol. 1998 Mar;36(3):855. Unique Identifier : AIDSLINE MED/98167760; Arya SC
Senate voting and social construction of target populations: a study of AIDS policy making, 1987-1992.: J Health Polit Policy Law. 1998 Feb;23(1):107-32. Unique Identifier : AIDSLINE MED/98182752; Schroedel JR; Jordan DR; Claremont Graduate University.; Scholars have devoted considerable attention to analyzing the social construction of AIDS. To explore the politics of AIDS policymaking, this research uses Schneider and Ingram s (1993) theory of the social construction of target populations to evaluate the U.S. Senate s response to AIDS between 1987 and 1992. Our stu
Respiratory isolation of tuberculosis patients using clinical guidelines and an automated clinical decision support system.: Infect Control Hosp Epidemiol. 1998 Feb;19(2):94-100. Unique Identifier : AIDSLINE MED/98168925; Knirsch CA; Jain NL; Pablos-Mendez A; Friedman C; Hripcsak G; Department of Medicine, College of Physicians and Surgeons, Columbia; University, New York City, USA.; OBJECTIVE: To evaluate a clinical guideline and an automated computer protocol for detection and respiratory isolation of tuberculosis (TB) patients. DESIGN: An automated computer protocol was tested on a retrospective cohort of adult culture-positive TB patients admitted from 1992 to 1993 to Columbia-Presbyterian Med
T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis.: J Immunol. 1998 Jan 15;160(2):1022-8. Unique Identifier : AIDSLINE MED/98211669; Gross DM; Steere AC; Huber BT; Tufts University School of Medicine, Department of Pathology, Boston,; MA 02111, USA.; Cytokines produced by subsets of CD4+ T helper cells responding to an infection influences the efficiency with which the host is able to mount a protective immune response. In an attempt to elucidate the population of active cells involved in the propagation of Lyme arthritis we have utilized intracellular cytokine st
Development of murine allergic asthma is dependent upon B7-2 costimulation.: J Immunol. 1998 Jan 15;160(2):1036-43. Unique Identifier : AIDSLINE MED/98211671; Keane-Myers AM; Gause WC; Finkelman FD; Xhou XD; Wills-Karp M; Department of Environmental Health Sciences, School of Hygiene and; Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Allergic asthma is thought to be mediated by CD4+ T lymphocytes producing the Th2-associated cytokines, IL-4, and IL-5. Recently, the costimulatory molecules B7-1 and B7-2, which are expressed on the surface of APC, have been suggested to influence the development of Th1 vs Th2 immune responses. We examined the in viv
T helper 1 and T helper 2 cells respond differentially to chemokines.: J Immunol. 1998 Jan 15;160(2):550-4. Unique Identifier : AIDSLINE MED/98211611; Siveke JT; Hamann A; Abteilung fur Immunologie, Medizinische Klinik,; Universitatskrankenhaus Eppendorf, Hamburg, Germany.; T effector subsets, such as Th1 or Th2 cells, are key players in inflammatory reactions. It is not known whether chemokines are able to recruit these subsets differentially, as has been shown for memory vs naive T cells. Here we demonstrate that Th1 and Th2 cells differ in their intrinsic migratory properties and thei
Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells.: J Immunol. 1998 Jan 15;160(2):559-65. Unique Identifier : AIDSLINE MED/98211613; Noble A; Pestano GA; Cantor H; Department of Cancer Immunology and AIDS, Dana Farber Cancer; Institute, Boston, MA 02115, USA.; Stimulation of mature CD4 cells through the TCR induces cellular activation and expansion that are often followed by clonal elimination by a form of apoptosis termed activation-induced cell death. This process of CD4 cell apoptosis is generally thought to reflect clonal suicide and to be independent of other cell type
Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses.: J Immunol. 1998 Jan 15;160(2):566-71. Unique Identifier : AIDSLINE MED/98211614; Noble A; Zhao ZS; Cantor H; Department of Cancer Immunology and AIDS, Dana Farber Cancer; Institute, Boston, MA 02115, USA.; We have investigated the role of MHC class I products and CD8 T cells in regulating Ab responses using beta2-microglobulin deficient (beta2m-/-) mice. Beta2m-/- mice produced stronger IgM and IgG responses than did control beta2m+/+ mice to both cellular and viral Ags. These Ab responses could be suppressed by infusio
Reduced T helper 1 responses in IL-12 p40 transgenic mice.: J Immunol. 1998 Jan 15;160(2):588-94. Unique Identifier : AIDSLINE MED/98211617; Yoshimoto T; Wang CR; Yoneto T; Waki S; Sunaga S; Komagata Y; Mitsuyama M; Miyazaki J; Nariuchi H; Department of Allergology, Institute of Medical Science, The; University of Tokyo, Japan.; To investigate the antagonistic effect of IL-12 p40 on IL-12 activity in vivo, we generated transgenic (Tg) mice in which p40 gene was regulated by a liver-specific promoter. Three Tg mouse lines were generated, and they expressed the p40 transgene predominantly in liver. Serum p40 level was extremely high, and it con
MHC class II expression in double mutant mice lacking invariant chain and DM functions.: J Immunol. 1998 Jan 15;160(2):606-14. Unique Identifier : AIDSLINE MED/98211619; Kenty G; Martin WD; Van Kaer L; Bikoff EK; Department of Molecular and Cellular Biology, The Biological; Laboratories, Harvard University, Cambridge, MA 02138, USA.; Invariant (Ii) chain and DM functions are required at distinct stages during class II maturation to promote occupancy by diverse peptide ligands. The class II molecules expressed by mutant mouse strains lacking Ii chain or DM activities display discrete structural and functional abnormalities. The present report descr
The level of CD4 surface protein influences T cell selection in the thymus.: J Immunol. 1998 Jan 15;160(2):634-42. Unique Identifier : AIDSLINE MED/98211622; Frank GD; Parnes JR; Department of Medicine, Stanford University School of Medicine, CA; 94305, USA.; During T cell development thymocytes are subjected to positive and negative selection criteria to ensure that the mature T cell repertoire is MHC restricted, yet self tolerant at the same time. The CD4 and CD8 coreceptors are thought to play a crucial role in this developmental process. To elucidate the role of CD4 in
Opposite CD4/CD8 lineage decisions of CD4+8+ mouse and rat thymocytes to equivalent triggering signals: correlation with thymic expression of a truncated CD8 alpha chain in mice but not rats.: J Immunol. 1998 Jan 15;160(2):700-7. Unique Identifier : AIDSLINE MED/98211630; Mitnacht R; Bischof A; Torres-Nagel N; Hunig T; Institute for Virology and Immunobiology, University of Wurzburg,; Germany.; Unselected CD4+8+ rat thymocytes, generated in vitro from their direct precursors, are readily converted to functional TCRhigh T cells by stimulation with immobilized TCR-specific mAb plus IL-2 . Lineage decision invariably occurs toward CD4-8+, regardless of the timing
Positive selection of thymocytes expressing the same TCR by different MHC ligands results in the production of functionally distinct thymocytes distinguished by differential expression of the heat stable antigen.: J Immunol. 1998 Jan 15;160(2):718-27. Unique Identifier : AIDSLINE MED/98211632; Teh HS; Motyka B; Teh SJ; Department of Microbiology and Immunology, University of British; Columbia, Vancouver, Canada.; The issue of whether the signaling process during positive selection can affect the efficiency by which the positively selected T cells respond to antigenic stimulation has not been addressed. We approached this question by determining the consequences of positive selection of a particular transgenic TCR 2C TCR) in th
Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa.: J Immunol. 1998 Jan 15;160(2):754-62. Unique Identifier : AIDSLINE MED/98211636; Grdic D; Hornquist E; Kjerrulf M; Lycke NY; Department of Medical Microbiology and Immunology, University of; Goteborg, Sweden.; We found that feeding keyhole limpet hemocyanin (KLH) to CD8-deficient (CD8-/-) mice induced oral tolerance that was comparable in both magnitude and quality to that induced in wild-type (wt) mice. The tolerance was dose dependent, and only higher doses of KLH caused significant reduction in specific Ab and T cell res
Presence of activated antigen-binding B cells during immunization enhances relative levels of IFN-gamma in T cell responses.: J Immunol. 1998 Jan 15;160(2):778-87. Unique Identifier : AIDSLINE MED/98211639; Pasare C; Morafo V; Entringer M; Bansal P; George A; Bal V; Rath S; Durdik JM; National Institute of Immunology, New Delhi, India.; To examine the influence of Ag presentation by B cells on immune responses, we have used mice transgenic for an Ig heavy chain from a monoclonal anti-azobenzenearsonate (Ars) Ab to deliver Ag to B cells during immunization. A large proportion of transgene-expressing B cells in these mice binds Ars, while transgenic se
CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen.: J Immunol. 1998 Jan 15;160(2):870-6. Unique Identifier : AIDSLINE MED/98211649; Davis HL; Weeranta R; Waldschmidt TJ; Tygrett L; Schorr J; Krieg AM; Loeb Research Institute, Ottawa Civic Hospital, ON, Canada.; hdavis@civich.ottawa.on.ca; Unmethylated CpG dinucleotides in bacterial DNA or synthetic oligodeoxynucleotides (ODN) cause B cell proliferation and Ig secretion, monocyte cytokine secretion, and activation of NK cell lytic activity and IFN-gamma secretion in vivo and in vitro. The potent immune activation by CpG ODN suggests possible utility for
Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity.: J Immunol. 1998 Jan 15;160(2):877-83. Unique Identifier : AIDSLINE MED/98211650; Hesselgesser J; Liang M; Hoxie J; Greenberg M; Brass LF; Orsini MJ; Taub D; Horuk R; Department of Immunology, Berlex BioSciences, Richmond, CA 94804, USA.; The CXCR4 chemokine receptor has been shown to respond to the C-X-C chemokine stromal-derived factor (SDF-1) and has recently been shown to be an important coreceptor for HIV-1 infection. In the present paper we have tested a number of human lymphocyte cell lines, including Jurkat, HUT78, CEM, and Sup-T1 for the prese
Perforin-deficient CD8+ T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha.: J Immunol. 1998 Jan 15;160(2):898-905. Unique Identifier : AIDSLINE MED/98211653; White DW; Harty JT; Interdisciplinary Graduate Program in Immunology, University of Iowa,; Iowa City 52242, USA.; CD8+ T cells are effective mediators of immunity against Listeria monocytogenes, but the mechanisms by which they provide antilisterial immunity are poorly understood. CD8+ T cells efficiently lyse target cells in vitro by at least two independent pathways. To test the hypothesis that CD8+ T cell-mediated immunity to
Gene organization and promoter function for CC chemokine receptor 5 (CCR5).: J Immunol. 1998 Jan 15;160(2):985-92. Unique Identifier : AIDSLINE MED/98211664; Guignard F; Combadiere C; Tiffany HL; Murphy PM; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892, USA.; CC chemokine receptor 5 (CCR5) functions physiologically as a receptor for the leukocyte chemoattractants macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and functions pathologically as a key cell entry coreceptor for HIV-1. The factors that regulate CCR5 expression may be us
Disseminated Rhodococcus equi and Nocardia farcinica infection in a patient with sarcoidosis [letter]: J Infect. 1998 Jan;36(1):134-5. Unique Identifier : AIDSLINE MED/98175443; Mohammedi I; Vedrinne JM; Floccard B; Reverdy ME; Duperret S; Motin J
Ganciclovir and foscarnet efficacy in AIDS-related CMV polyradiculopathy.: J Infect. 1998 Jan;36(1):29-33. Unique Identifier : AIDSLINE MED/98175416; Anders HJ; Weiss N; Bogner JR; Goebel FD; The Medical Policlinic, Ludwigs-Maximilian University, Munich,; Germany.; Cytomegalovirus ( CMV ) polyradiculopathy is a rare complication of AIDS in which ascending motor weakness, sensory loss and urinary retention are associated with polymorphonuclear pleocytosis and positive CMV polymerase chain reaction in the cerebrospinal fluid C
Variation in morphotype, karyotype and DNA type of fluconazole resistant Candida albicans from an AIDS patient.: J Infect. 1998 Jan;36(1):57-62. Unique Identifier : AIDSLINE MED/98175421; Takasuka T; Baily GG; Birch M; Anderson MJ; Law D; Denning DW; Department of Medicine, University of Manchester School of Medicine,; UK.; Azole-resistant oropharyngeal and oesophageal candidiasis is a recent phenomenon observed in patients with AIDS usually previously treated with fluconazole. Some variation has been observed in antifungal susceptibility testing among separate colonies of Candida albicans from the same patient. This raises the question
Antibodies to mycoplasma fermentans in HIV-positive heterosexual patients: seroprevalence and association with AIDS.: J Infect. 1998 Jan;36(1):79-84. Unique Identifier : AIDSLINE MED/98175425; Horowitz S; Horowitz J; Hou L; Fuchs E; Rager-Zisman B; Jacobs E; Alkan M; Department of Microbiology and Immunology, Faculty of Health Sciences,; Soroka Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva,; Israel.; There are conflicting reports concerning the prevalence of Mycoplasma fermentans in HIV-positive patients and its association with AIDS. Serum antibodies to M. fermentans were measured by a modified immunoblotting technique in 48 HIV-positive heterosexual patients and in 30 HIV-negative heterosexual controls. Antibodi
The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells.: J Leukoc Biol. 1998 Apr;63(4):418-28. Unique Identifier : AIDSLINE MED/98204129; Mackey MF; Barth RJ Jr; Noelle RJ; Department of Microbiology, Dartmouth Medical School and the Norris; Cotton Cancer Center, Lebanon, New Hampshire 03756, USA.; This review focuses on the emerging body of literature suggesting a critical role for CD40/CD154 interactions in antigen-presenting cell (APC) activation, CD4+ and CD8+ T cell priming, and effector T cell maturation. In this context effective antigen presentation involves not only T cell expansion and long-term surviv
HIV-1 induces human monocyte-derived macrophages to produce C3 and to fix C3 on their surface.: J Leukoc Biol. 1998 Apr;63(4):463-8. Unique Identifier : AIDSLINE MED/98204134; Bajtay Z; Kacani L; Erdei A; Dierich MP; Department of Immunology, Eotvos Lorand University, God, Hungary.; Complement components, particularly C3, are known to be involved in the pathogenesis of AIDS and macrophages may serve as a source of C3 at sites of infection. We investigated whether the interaction between HIV-1 and monocytes has any effect on C3 production by the cells. Monocytes isolated from the blood of healthy
Detection of HIV proviral DNA on toothbrushes: a preliminary study.: J Okla Dent Assoc. 1994 Winter;84(3):17-20. Unique Identifier : AIDSLINE MED/98186984; Glass RT; Carson SR; Barker RL; Peiper SC; Shapiro S; Department of Oral Pathology, University of Oklahoma College of; Dentistry, USA.
Optimal conditions of immune complex transfer enzyme immunoassay for p24 antigen of HIV-1.: J Clin Lab Anal. 1998;12(2):115-20. Unique Identifier : AIDSLINE MED/98184982; Hashida S; Ishikawa S; Hashinaka K; Nishikata I; Saito A; Takamizawa A; Shinagawa H; Ishikawa E; Department of Biochemistry, Miyazaki Medical College, Kiyotake, Japan.; In the immune complex transfer enzyme immunoassay for HIV-1 p24 antigen, different preparations of anti-p24 Fab -beta-D-galactosidase conjugate, various periods of time for immunoreactions involved, and shaking for incubations with polystyrene beads were tested. On the basis of the results of these experiments, p24 an
Optimal conditions of immune complex transfer enzyme immunoassays for antibody IgGs to HIV-1 using recombinant p17, p24, and reverse transcriptase as antigens.: J Clin Lab Anal. 1998;12(2):98-107. Unique Identifier : AIDSLINE MED/98184980; Hashida S; Ishikawa S; Hashinaka K; Nishikata I; Oka S; Shimada K; Saito A; Takamizawa A; Shinagawa H; Ishikawa E; Department of Biochemistry, Miyazaki Medical College, Japan.; The immune complex transfer enzyme immunoassays for antibody IgGs to p17, p24, and reverse transcriptase (RT) of HIV-1 were tested under various conditions. Antibody IgGs to HIV-1 were reacted for up to 20 hr with 2,4-dinitrophenyl-bovine serum albumin-recombinant HIV-1 protein conjugates and recombinant HIV-1 protein
A pilot study of combination therapy with indinavir, stavudine d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus.: J Pediatr. 1998 Mar;132(3 Pt 1):543-6. Unique Identifier : AIDSLINE MED/98204481; Kline MW; Fletcher CV; Harris AT; Evans KD; Brundage RC; Remmel RP; Calles NR; Kirkpatrick SB; Simon C; Department of Pediatrics, Baylor College of Medicine and Texas; Children's Hospital, Houston 77030, USA.; Twelve children infected with the human immunodeficiency virus were treated orally with indinavir , stavudine , plus didanosine for 12 to 48 weeks. Therapy was limited in some cases by
[12th World AIDS Conference announces call for abstracts--Geneva to host world's foremost AIDS Conference; focus on "bridging the gap"]: Nippon Seirigaku Zasshi. 1997;59(12):469-70. Unique Identifier : AIDSLINE MED/98187495
The costs of triple-drug anti-HIV therapy for adults in the Americas [letter]: JAMA. 1998 Apr 22-29;279(16):1263-4. Unique Identifier : AIDSLINE MED/98224676; Montaner JS; Hogg RS; Weber AE; Anis AH; O'Shaughnessy MV; Schechter MT
Sex-related alcohol expectancies as moderators of the relationship between alcohol use and risky sex in adolescents.: J Stud Alcohol. 1998 Jan;59(1):71-7. Unique Identifier : AIDSLINE MED/98158083; Dermen KH; Cooper ML; Agocha VB; Research Institute on Addictions, Buffalo, New York 14203, USA.; OBJECTIVE: Alcohol is frequently identified as a potential contributor to HIV-related sexual risk taking. Drawing on alcohol expectancy explanations for postdrinking behavior, the present study tested the hypothesis that adolescents who drink alcohol on a given occasion will be more likely to engage in sexual risk-tak
Heterogeneity in the relationship between the time tradeoff and Short Form-36 for HIV-infected and primary care patients.: Med Care. 1998 Apr;36(4):523-32. Unique Identifier : AIDSLINE MED/98204150; Bult JR; Hunink MG; Tsevat J; Weinstein MC; Monitor Company, Cambridge, MA, USA.; OBJECTIVES: Evidence in the literature suggests that the overall correlation between descriptive and valuational measures of health are weak to moderate. In this study, the relationship between descriptive health status measures, obtained using the Short-Form 36, and health values, measured with the time tradeoff, was
Functional status transitions and survival in HIV disease: evidence from the AIDS Costs and Service Utilization Survey.: Med Care. 1998 Apr;36(4):533-43. Unique Identifier : AIDSLINE MED/98204151; Fleishman JA; Crystal S; Center for Cost and Financing Studies, Agency for Health Care Policy; and Research, Rockville, MD 20852, USA.; OBJECTIVE: The authors examined the prevalence of limitations in physical functioning in a large sample of people with human immunodeficiency virus (HIV) infection and the patterns of change in their functional status with time. METHODS: Patients receiving treatment for HIV infection were sampled from 26 providers in
[Recommendations on antiretroviral treatment. The AIDS Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology]: Med Clin (Barc). 1998 Jan 31;110(3):109-16. Unique Identifier : AIDSLINE MED/98195631; Moreno S; Arrizabalaga J; Gatell JM; Clotet B; Aguirrebengoa K; Antela A; Iribarren JA; Laguna F; Miro JM; Ocana I; Rubio R; Viciana P; Podzamczer D; Hospital Morales Meseguer, Murcia.
[Prevalence of oral lesions diagnosed in a group of intravenous drug addict prisoners with AIDS and their correlation with CD4 lymphocyte count (letter)]: Med Clin (Barc). 1998 Jan 31;110(3):119. Unique Identifier : AIDSLINE MED/98195635; Esparza Gomez GC; Garcia-Pola Vallejo MJ; Aguirre Urizar JM; Giron Morazo FJ
Antiretrovirals during pregnancy in HIV-1-positive women in New York City [letter]: Lancet. 1998 Apr 4;351(9108):1029-30. Unique Identifier : AIDSLINE MED/98206588; Fischer C; Rosenwald V; Harewood L; Blum C
US court to rule whether HIV infection constitutes disability [news]: Lancet. 1998 Apr 4;351(9108):1041. Unique Identifier : AIDSLINE MED/98206600; McCarthy M
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1056; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206605; Di Perri G; Bonora S; Vento S; Allegranzi B; Concia E
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1056-7; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206606; French M; Lenzo N; John M; Mallal S; Price P
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1057-8; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206607; Behrens G; Knuth C; Schedel I; Mendila M; Schmidt RE
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1058; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206608; Harindra V; Foley E
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1058; discussion 1058-9. Unique Identifier : AIDSLINE MED/98206609; Vento S; Renzini C; Casali F; Ghironzi G; Concia E
Highly active antiretroviral therapy [letter]: Lancet. 1998 Apr 4;351(9108):1059-60. Unique Identifier : AIDSLINE MED/98206610; Drobniewski F; Eltringham I
[Genetic predisposition to infectious diseases]: Med Trop (Mars). 1997;57(3 Suppl):10-2. Unique Identifier : AIDSLINE MED/98174357; Dessein A; INSERM U399 Immunologie et Genetique des Maladies Parasitaires,; Faculte de Medecine, Marseille, France.; At the present time more is known about barriers to transmission of infectious agents between species than barriers to transmission within the same species. However differences in resistance to infection have been well-established within given species of various plants and domestic farm animals. Unsurprisingly several
HIV-protease inhibitors.: N Engl J Med. 1998 Apr 30;338(18):1281-92. Unique Identifier : AIDSLINE MED/98213300; Flexner C; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, MD, USA.
Hepatitis B virus infection [letter]: N Engl J Med. 1998 Apr 30;338(18):1311-2; discussion 1312-3. Unique Identifier : AIDSLINE MED/98213306; Abramowicz D; Blanpain C; Knoop C
Hepatitis B virus infection [letter]: N Engl J Med. 1998 Apr 30;338(18):1312; discussion 1312-3. Unique Identifier : AIDSLINE MED/98213307; Koblin BA; Taylor PE; Stevens CE
AIDS therapy in Brazil [letter]: Nature. 1998 Apr 2;392(6675):431. Unique Identifier : AIDSLINE MED/98208020; Castello-Branco LR; Linhares-Carvalho MI; Ponce de Leon AC
[Longitudinal echocardiographic study of HIV positive patients]: Minerva Cardioangiol. 1997 Nov;45(11):573-9. Unique Identifier : AIDSLINE MED/98210457; Cottini E; Raspagliesi M; Giacone G; Cosentino M; Rando G; Vintaloro G; Cirino A; Spagnoli R; Istituto di Clinica Medica II L. Condorellio, Universita degli Studi,; Catania.; BACKGROUND: From May 1992 to June 1996 the authors have studied a group of 39 subjects with positive anti-HIV, with echo 2D color Doppler examination, to evaluate with semi-annual controls, the wide variety of cardiac complications in the various phases of clinical evolution of the illness. METHODS: At the moment of r
[Laboratory diagnosis of intestinal micro-parasitosis in AIDS patients: state of the art]: Minerva Med. 1998 Jan-Feb;89(1-2):23-7. Unique Identifier : AIDSLINE MED/98221793; Terra L; Pellicano S; Milano M; Ospedale S. Giovanni di Dio, Divisione di Malattie Infettive, ASL n.; 5, Crotone.; BACKGROUND: The diarrhea, often associated with growing thin and weight loss, is important for nutritional state and quality of life in AIDS patients. It was demonstrated that patients with AIDS who present diarrhea have a greater degree of immunosuppression than those without diarrhea, predisposing the gastrointestin
Human renal allograft rejection: molecular characterization.: Nephrol Dial Transplant. 1998;13 Suppl 1:21-4. Unique Identifier : AIDSLINE MED/98168336; Suthanthiran M; Department of Medicine, New York Hospital-Cornell Medical Center, NY,; USA.
Donor insemination and human immunodeficiency virus transmission.: Obstet Gynecol. 1998 Apr;91(4):515-8. Unique Identifier : AIDSLINE MED/98200002; Wortley PM; Hammett TA; Fleming PL; Division of HIV/AIDS Prevention, National Centers for HIV, STD, and TB; Prevention, Centers for Disease Control and Prevention, Atlanta,; Georgia 30333, USA. pmwl@cdc.gov; OBJECTIVE: To describe cases of AIDS attributed to donor insemination identified through national human immunodeficiency virus (HIV)/AIDS surveillance and to compare the number identified through surveillance with our estimate of the number of women infected as a result of donor insemination before the initiation of d
Human immunodeficiency virus test refusal in pregnancy: a challenge to voluntary testing.: Obstet Gynecol. 1998 Apr;91(4):540-5. Unique Identifier : AIDSLINE MED/98200006; Carusi D; Learman LA; Posner SF; Department of Obstetrics, Gynecology and Reproductive Sciences,; University of California, San Francisco, USA.; OBJECTIVE: To determine if awareness of methods to reduce vertical transmission of human immunodeficiency virus (HIV) is associated with HIV test acceptance and to clarify patients attitudes toward routine versus elective prenatal HIV testing. METHODS: In a cross-sectional study, 247 antenatal patients were surveyed
Characterization of receptors with a new negative image: use in molecular docking and lead optimization.: Proteins. 1998 Feb 15;30(3):321-36. Unique Identifier : AIDSLINE MED/98176724; Oshiro CM; Kuntz ID; Department of Pharmaceutical Chemistry, University of California, San; Francisco 94143, USA.; The characterization of receptor binding sites is an important aspect of molecular docking, molecular recognition, and the structure-based design process. This characterization can take several forms: the receptor surface itself can be delineated or described, the space adjacent to the surface can be chemically mapped
[Diabetes and hyperglycemia in patients under treatment for HIV infection with the protease inhibitors indavir, ritonavir, saquinavir as well as nelfinavir (in development, but not yet released (news)]: Pharm Unserer Zeit. 1997 Dec;26(6):317. Unique Identifier : AIDSLINE MED/98174761
The relationship of mood, endocrine, and sexual disorders in human immunodeficiency virus positive (HIV+) women: an exploratory study.: Psychosom Med. 1998 Jan-Feb;60(1):11-6. Unique Identifier : AIDSLINE MED/98151197; Goggin K; Engelson ES; Rabkin JG; Kotler DP; Aaron Diamond Foundation, New York State Psychiatric Institute,; Cornell Medical College, USA.; OBJECTIVE: This exploratory study assessed the prevalence of mood disorders, sexual disorders, and endocrine abnormalities, and explored the relationship between these parameters in a sample of HIV+ women. METHOD: Fifty-four HIV+ women were evaluated with the Structured Clinical Interview for DSM-III-R (SCID) and meas
Epstein-Barr virus-induced lymphoblastoid cell lines from patients with primary immunodeficiency diseases.: Scand J Immunol. 1980;11(2):155-62. Unique Identifier : AIDSLINE MED/98198145; Tsuchiya S; Konno T; Tada K; Ono Y; Department of Pediatrics, Tohoku University School of Medicine,; Sendai, Japan.; Peripheral lymphocytes from eight patients with congenital immunodeficiency diseases were infected with Epstein-Barr virus EBV) in an attempt to establish B lymphoblastoid cell lines LCL). These patients included three boys with congenital agammaglobulinaemia, two girls with hypogammaglobulinaemia, one boy with common
Lives in the balance [news]: Sci Am. 1998 Apr;278(4):17-8. Unique Identifier : AIDSLINE MED/98193960; Beardsley T
Viruses have many ways to be unwelcome guests [news]: Science. 1998 Apr 10;280(5361):204-5. Unique Identifier : AIDSLINE MED/98225996; Balter M
The numbers game for virus-specific CD8+ T cells.: Science. 1998 Apr 10;280(5361):227. Unique Identifier : AIDSLINE MED/98225998; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA. peter.doherty@stjude.org
Crystal structure and evolution of a transfer RNA splicing enzyme.: Science. 1998 Apr 10;280(5361):279-84. Unique Identifier : AIDSLINE MED/98202609; Li H; Trotta CR; Abelson J; Division of Biology, Mail Code 147-75, California Institute of; Technology, Pasadena, CA 91125, USA.; The splicing of transfer RNA precursors is similar in Eucarya and Archaea. In both kingdoms an endonuclease recognizes the splice sites and releases the intron, but the mechanism of splice site recognition is different in each kingdom. The crystal structure of the endonuclease from the archaeon Methanococcus jannaschi
Medical management of the pregnant woman infected with human immunodeficiency virus type 1 and her child.: Semin Perinatol. 1998 Feb;22(1):72-86. Unique Identifier : AIDSLINE MED/98184002; Andiman WA; Department of Pediatrics, Yale University School of Medicine, New; Haven, CT 06520, USA.; Heterosexual contact and intravenous drug use continue to result in new cases of human immunodeficiency virus type 1 (HIV-1) infection among adolescents and women of childbearing age. In North American and European surveys, 0.1% to 0.3% of childbearing women are infected with HIV; rates are 10 to 20 times higher in so
Depletion of mitochondrial DNA by ddC in untransformed human cell lines.: Somat Cell Mol Genet. 1997 Jul;23(4):287-90. Unique Identifier : AIDSLINE MED/98203657; Nelson I; Hanna MG; Wood NW; Harding AE; Department of Clinical Neurology, Institute of Neurology, Queen; Square, London.; In order to study the interaction between the nuclear and mitochondrial genomes we have developed a non-transformed cell system. It is based upon the complete removal of mtDNA from fibroblasts by treatment with a nucleoside analogue, 2 ,3 dideoxycytidine (
Prenatal human immunodeficiency virus and sexually transmitted disease screening. Getting the message across [editorial]: Sex Transm Dis. 1998 Mar;25(3):137-8. Unique Identifier : AIDSLINE MED/98185678; Greenblatt RM
Do spermicides containing nonoxynol-9 prevent sexually transmitted infections? A meta-analysis.: Sex Transm Dis. 1998 Mar;25(3):144-50. Unique Identifier : AIDSLINE MED/98185680; Cook RL; Rosenberg MJ; Robert Wood Johnson Clinical Scholars Program, University of North; Carolina at Chapel Hill, USA.; BACKGROUND AND OBJECTIVES: There are conflicting opinions on whether to recommend spermicides containing nonoxynol-9 for prevention of sexually transmitted diseases, including human immunodeficiency virus (HIV). GOAL: To systematically review and summarize the medical literature on the effect of spermicides containing
Physicians' practices and opinions regarding prenatal screening for human immunodeficiency virus and other sexually transmitted diseases.: Sex Transm Dis. 1998 Mar;25(3):169-75. Unique Identifier : AIDSLINE MED/98185684; Mills WA; Martin DL; Bertrand JR; Belongia EA; Acute Disease Epidemiology Section, Minnesota Department of Health,; Minneapolis 55440, USA.; BACKGROUND AND OBJECTIVES: Early prenatal diagnosis of sexually transmitted diseases (STDs), particularly human immunodeficiency virus (HIV), is critical for maternal and infant health. We conducted a survey to assess physicians prenatal STD screening practices and opinions. STUDY DESIGN: A random sample of obstetric
Oral malignancies diagnosed in an HIV-dedicated dental clinic.: Tex Dent J. 1996 Jun;113(6):49-57. Unique Identifier : AIDSLINE MED/98179352; Flaitz CM; Nichols CM; Hicks MJ; Division of Oral Pathology, University of Texas-Houston, Health; Science Center Dental Branch 77030-3402, USA.
Selective quasispecies transmission after systemic or mucosal exposure of macaques to simian immunodeficiency virus.: Virology. 1998 Mar 30;243(1):12-20. Unique Identifier : AIDSLINE MED/98201641; Neildez O; Le Grand R; Caufour P; Vaslin B; Cheret A; Matheux F; Theodoro F; Roques P; Dormont D; CEA, Service de Neurovirologie, CRSSA, Fontenay aux Roses, France.; Sexual transmission is the major cause of the AIDS epidemic. For the development of new antiviral and vaccine strategies, we therefore need to understand the mechanisms by which lentiviruses cross the mucosal barrier and the subsequent pathogenic consequences. For this purpose, experimental approaches are greatly faci
Reactivities of human sera with human herpesvirus-8-infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs.: Virology. 1998 Mar 30;243(1):208-17. Unique Identifier : AIDSLINE MED/98201660; Chandran B; Smith MS; Koelle DM; Corey L; Horvat R; Goldstein E; Department of Microbiology, Molecular Genetics and Immunology,; University of Kansas Medical Center, Kansas City 66160, USA.; bchandra@kumc.edu; The reactivates of human sera with uninduced and phorbol ester TPA)-induced human herpesvirus-8 (HHV-8)-infected BCBL-1 cells were examined by immunofluorescence assay (IFA) and by radioimmunoprecipitation reactions (RIP). The seroprevalence of HHV-8 infections is low in the United States
Identification and characterization of virus assembly intermediate complexes in HIV-1-infected CD4+ T cells.: Virology. 1998 Mar 30;243(1):78-93. Unique Identifier : AIDSLINE MED/98201647; Lee YM; Yu XF; Department of Molecular Microbiology and Immunology, School of Hygiene; and Public Health, Johns Hopkins University, Baltimore, Maryland; 21205, USA.; For type-C and lentiviruses, including human immunodeficiency virus type 1 (HIV-1), the pathway of virus assembly remains poorly defined, and the assembly and budding of capsids are believed to occur simultaneously at the plasma membrane of the infected cell. We have now identified two putative HIV-1 assembly intermed
Activation of BLV transcription by NF-kappa B and Tax.: Virology. 1998 Mar 30;243(1):94-8. Unique Identifier : AIDSLINE MED/98201648; Brooks PA; Cockerell GL; Nyborg JK; Department of Pathology, Colorado State University, Fort Collins; 80523, USA.; Bovine leukemia virus (BLV) is the causative agent of bovine leukosis, a naturally occurring fatal disease in cattle. BLV transcription is regulated by cellular transcription factors and the virally encoded oncoprotein Tax. In this report, we investigated the functional role of the putative NF-kappa B binding site rec
The origin and evolution of human T-cell lymphotropic virus types I and II.: Virus Genes. 1998;16(1):69-84. Unique Identifier : AIDSLINE MED/98223987; Suzuki Y; Gojobori T; Center for Information Biology, National Institute of Genetics,; Mishima, Japan.; Studies on human T-cell lymphotropic virus types I (HTLV-I) and II (HTLV-II) are briefly reviewed from the viewpoint of molecular evolution, with special reference to the evolutionary rate and evolutionary relationships among these viruses. In particular, it appears that, in contrast to the low level of variability of
Angioimmunoblastic lymphadenopathy with dysproteinemia: emphasis on pathogenesis and treatment.: Acta Haematol. 1998;99(2):57-64. Unique Identifier : AIDSLINE MED/98213113; Sallah S; Gagnon GA; Division of Hematology/Oncology, East Carolina University Medical; School, Greenville, NC 27858, USA.; Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a rare lymphoproliferative disorder characterized by diffuse lymphadenopathy, fever, hepatosplenomegaly, hemolytic anemia, and polyclonal hypergammaglobulinemia. Morphologically, the involved lymph nodes demonstrate complete effacement of the normal arch
Antiretroviral therapy in human immunodeficiency virus-infected individuals.: Adv Intern Med. 1998;43:373-402. Unique Identifier : AIDSLINE MED/98167088; Spooner KM; Department of Internal Medicine, National Naval Medical Center,; Bethesda, Maryland, USA.
AIDS in persons 50 years of age and older [news]: Am Fam Physician. 1998 Apr 1;57(7):1691-2. Unique Identifier : AIDSLINE MED/98217399
Volunteer participation in context: motivations and political efficacy within three AIDS organizations.: Am J Community Psychol. 1997 Dec;25(6):809-37. Unique Identifier : AIDSLINE MED/98195709; Stewart E; Weinstein RS; Department of Psychology, University of Illinois at Urbana-Champaign; 61820, USA.; Employed quantitative and qualitative data in a contextual examination of participation in three San Francisco-area HIV/AIDS organizations: an urban, gay community-based social change setting; an urban, broadly focused information/referral setting; and a suburban individual support setting. The settings attracted diff
Regression of cytomegalovirus retinitis associated with protease-inhibitor treatment in patients with AIDS [letter]: Am J Ophthalmol. 1998 Apr;125(4):567-8. Unique Identifier : AIDSLINE MED/98218654; Tanguilig GG; Rutzen AR; Ortega-Larrocea G
Post-transcriptional induction of p21cip1 protein in condylomata and dysplasias is inversely related to human papillomavirus activities.: Am J Pathol. 1998 Apr;152(4):1015-24. Unique Identifier : AIDSLINE MED/98206438; Schmidt-Grimminger DC; Wu X; Jian Y; Broker TR; Chow LT; The Department of Biochemistry and Molecular Genetics, University of; Alabama at Birmingham, 35294-0005, USA.; Infections of the genital and oral epithelia by human papillomaviruses cause condylomata, papillomas, and squamous intraepithelial neoplasms, some of which can progress to invasive cancers. We describe an induction of p21cip1/WAF1/sdi1 protein in a fraction of the spinous cells in benign lesions and in cervical intrae
Histologic and immunophenotypic features prior to transformation in patients with transformed cutaneous T-cell lymphoma: is CD25 expression in skin biopsy samples predictive of large cell transformation in cutaneous T-cell lymphoma?: Am J Dermatopathol. 1998 Feb;20(1):1-6. Unique Identifier : AIDSLINE MED/98163189; Stefanato CM; Tallini G; Crotty PL; Department of Pathology, Yale University Medical School, New Haven,; CT, USA.; Large cell transformation (LCT) in cutaneous T-cell lymphoma CTCL) is estimated to occur up to approximately 20% of patients. This morphologic change is associated with aggressive behavior and shortened survival. Our purpose was to identify morphologic and/or immunophenotypic features in CTCL skin biopsies that are pr
The evaluation of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in cutaneous lesions of Kaposi's sarcoma: a study of formalin-fixed paraffin-embedded tissue.: Am J Dermatopathol. 1998 Feb;20(1):7-11. Unique Identifier : AIDSLINE MED/98163190; Herman PS; Shogreen MR; White WL; Department of Pathology, Bowman Gray School of Medicine/Wake Forest; University, Winston-Salem, North Carolina 27157, USA.; The etiologic role of human herpesvirus 8 (HHV8) in Kaposi s sarcoma (KS) remains controversial. This polymerase chain reaction (PCR)-based study was undertaken to evaluate the relationship of HHV8 in KS from our geographical region and to determine its utility in formalin-fixed, paraffin-embedded biopsy specimens. Fo
Correlates of infection control practices in dentistry.: Am J Infect Control. 1998 Feb;26(1):29-34. Unique Identifier : AIDSLINE MED/98163840; Gershon RR; Karkashian C; Vlahov D; Grimes M; Spannhake E; Department of Environmental Health Science, School of Public Health,; Johns Hopkins University, Baltimore, MD 21205, USA.; BACKGROUND: Studies conducted in the first decade of the AIDS epidemic indicated that, in general, dentists had suboptimal levels of compliance with standard infection control practices, including work practices designed to reduce exposure to bloodborne pathogens. This study was designed to assess current rates of com
[Human herpesvirus 8]: Ann Med Interne (Paris). 1997;148(5):385-9. Unique Identifier : AIDSLINE MED/98199215; Agut H; Dupin N; Aubin JT; Huraux JM; Laboratoire de Virologie du CERVI, Groupe Hospitalier; Pitie-Salpetriere, Paris.; Human herpesvirus 8 (HHV-8, KSHV) is a novel virus for which fragments of genomic sequence were identified in 1994. This was done by means of a differential amplification technique applied to the DNA of Kaposi s sarcoma lesions and normal tissues obtained from the same individual. The analysis of nucleotide sequence h
[HTLV I virus infection disclosed by recurrent scabies associated with genital condylomatosis]: Ann Med Interne (Paris). 1997;148(5):406-7. Unique Identifier : AIDSLINE MED/98199218; Dupin M; Guennoc B; Zimmermann R; Martin L; Verrier B; Flechaire A; Combemale P; Service de Dermatologie, Hopital d'Instruction des Armees Desgenettes,; Lyon.
[Specific bronchial sites of Mycobacterium kansasii in 2 patients with human immunodeficiency virus infection]: Ann Med Interne (Paris). 1997;148(8):577-8. Unique Identifier : AIDSLINE MED/98199205; Boudon P; Lepennec MP; Malbec D; Mathieu M; Choudat L; Valeyre D; Service de Medecine Interne, Hopital Robert Ballanger,; Aulnay-sous-Bois.
Optic neuritis heralding varicella zoster virus retinitis in a patient with acquired immunodeficiency syndrome.: Ann Neurol. 1998 Apr;43(4):534-6. Unique Identifier : AIDSLINE MED/98206414; Meenken C; van den Horn GJ; de Smet MD; van der Meer JT; Department of Ophthalmology, Academic Medical Center, University of; Amsterdam, The Netherlands.; We report on a 29-year-old severely compromised acquired immunodeficiency syndrome patient who developed retrobulbar optic neuritis 5 weeks after an episode of cutaneous herpes zoster infection. During the optic neuritis, varicella zoster virus could be demonstrated in the cerebrospinal fluid. The neuritis responded w
Treatment of cytomegalovirus retinitis with intraocular implants.: AORN J. 1998 Feb;67(2):356-60, 362-5, 368; quiz 369-72. Unique Identifier : AIDSLINE MED/98166016; Costabile BS; Ophthalmology Department, National Naval Medical Center, Bethesda, MD,; USA.; Cytomegalovirus ( CMV ) retinitis affects 20% to 40% of patients with AIDS and is the leading cause of vision loss associated with AIDS. Three treatment options currently exist (ie, IV administration of antiviral medications, intravitreal injections of ganciclovir
Lymphoma of the tympanic membrane in acquired immunodeficiency syndrome.: Auris Nasus Larynx. 1998 Jan;25(1):89-94. Unique Identifier : AIDSLINE MED/98173955; Goodarzi MO; Broberg TG; Lalwani AK; Department of Otolaryngology-Head and Neck Surgery, University of; California, San Francisco 94143-0342, USA.; Lymphoproliferative disease is more common in the immunocompromised host and can occur at unusual sites. Lymphomas of the temporal bone are rare. We present the first case of a large B-cell Lymphoma of the tympanic membrane in a patient with acquired immunodeficiency syndrome. The tympanic membrane is a site rich with
Arthralgias and cryoglobulinemia during protease inhibitor therapy in a patient infected with human immunodeficiency virus and hepatitis C virus.: Arthritis Rheum. 1998 Apr;41(4):740-3. Unique Identifier : AIDSLINE MED/98209857; Monsuez JJ; Vittecoq D; Musset L; Alemanni M; Dussaix E; Autran B; Hopital Paul Brousse, Villejuif, France.; We present the case of a woman who had a chronic infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). She developed severe polyarthralgias associated with type II mixed cryoglobulinemia during therapy with an HIV-1 protease inhibitor. This therapy resulted in a dramatic increase in her CD4+ T
Vaginal immunization with recombinant gram-positive bacteria.: Am J Reprod Immunol. 1998 Mar;39(3):199-208. Unique Identifier : AIDSLINE MED/98187357; Medaglini D; Oggioni MR; Pozzi G; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; PROBLEM: Many viral and bacterial pathogens enter the body through the genital mucosa. Therefore, one of the major goals of a vaccine against sexually transmitted diseases (STDs) should be to induce an immune response in the genital mucosa capable of controlling the entry of the pathogen. Our approach for the developm
Influence of the estrous cycle on the presence and distribution of immune cells in the rat reproductive tract.: Am J Reprod Immunol. 1998 Mar;39(3):209-16. Unique Identifier : AIDSLINE MED/98187358; Kaushic C; Frauendorf E; Rossoll RM; Richardson JM; Wira CR; Department of Physiology, Dartmouth Medical School, Lebanon, New; Hampshire 03756-0001, USA.; PROBLEM: Previous studies have shown that the uterus and vagina contain cells that can present antigen to ovalbumin-specific T-cells. The objective of the present study was to systematically characterize the immune cells [major histocompatibility complex MHC) class-II+, macrophages, granulocytes, dendritic cells, and
HIV transmission via breastfeeding: reflection on the issues [letter]: J Hum Lact. 1998 Mar;14(1):13. Unique Identifier : AIDSLINE MED/98205533; Spangler AK
Inhibition of human immunodeficiency