The role of CD1 molecules in immune responses to infection [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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The role of CD1 molecules in immune responses to infection [see comments]

Curr Opin Immunol. 1997 Aug;9(4):456-61. Unique Identifier : AIDSLINE /MED97433396
Maher JK; Kronenberg M; Department of Microbiology, Molecular Biology Institute University of; California at Los Angeles, Los Angeles, CA 90095, USA. juli@liai.org

Abstract: Recent work on CD1 molecules has demonstrated that human CD1b and a lipoglycan from mycobacteria that CD1b presents colocalize to late endosomes. Presentation of this lipoglycan by CD1b requires antigen uptake via the mannose receptor. CD8(+) CD1-restricted T cells can decrease the load of intracellular mycobacteria by granule release. TCR-transgenic and CD1-deficient mice have provided insights into the role of CD1 in the T helper responses required for the clearance of some microorganisms.
Keywords: *Antigen Presentation/IMMUNOLOGY *Antigens, CD1/PHYSIOLOGY *Infection/IMMUNOLOGYKWDantigenpresentation/immunologyKWDantigens,cd1/physiologyKWDinfection/immunology
Comment in: Curr Opin Immunol 1997 Aug;9(4):453-5
980130
M9811091

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