The impact of host genetics on susceptibility to human infectious diseases.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

The impact of host genetics on susceptibility to human infectious diseases.

Curr Opin Immunol. 1997 Aug;9(4):509-16. Unique Identifier : AIDSLINE /MED97433404
Abel L; Dessein AJ; Institut National de la Sante Et de la Recherche Medicale,; Mathematical and Statistical Modeling in Biology and Medicine, Centre; Hospitalo-Universitaire Pitie-Salpetriere, Paris, France. abel@biomath

Abstract: The development of genetic epidemiology methods using recent human genetic mapping information, together with the growing availability of candidate genes, has led to major advances in the identification of host genes involved in human infectious diseases. Within the past year, highlights include the mapping of a locus controlling the intensity of infection by Schistosoma mansoni, the demonstration that mutations in the interferon-gamma receptor 1 gene are causative of disseminated infection due to weakly pathogenic mycobacteria, and the identification, in the CCR5 gene, of a deletion which provides high protection against HIV-1 infection. The impact of these findings on the understanding of infectious disease pathogenesis and on the design of future preventive and therapeutic strategies should be considerable.

Keywords: *Infection/IMMUNOLOGY
980130
M9811089

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