Recombinant viruses as vaccines and immunological tools [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Recombinant viruses as vaccines and immunological tools [see comments]

Curr Opin Immunol. 1997 Aug;9(4):517-24. Unique Identifier : AIDSLINE /MED97433405
Rolph MS; Ramshaw IA; Department of Immunology, Max Planck Institute for Infection Biology,; Monbijoustrasse 2, D-10117, Berlin, Germany. rolph@mpiib-berlin.mpg.de

Abstract: Recombinant viruses have been investigated as candidate vaccines, and have also been used extensively as immunological tools. Recent advances in this area include the following: the construction and testing of a recombinant simian immunodeficiency virus encoding human interferon-gamma; the development of new vectors such as recombinant poliovirus; and the generation of polyepitope vaccines. Basic immunological research has benefited from the use of recombinant viruses to further understand the role of molecules such as CD40 ligand, nitric oxide and interleukin-4.
Keywords: *Immunologic Techniques *Vaccines, Synthetic/IMMUNOLOGYKWDimmunologictechniquesKWDvaccines,synthetic/immunology
Comment in: Curr Opin Immunol 1997 Aug;9(4):453-5
980130
M9811088

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