Co-receptors for HIV-1 entry [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Co-receptors for HIV-1 entry [see comments]

Curr Opin Immunol. 1997 Aug;9(4):551-62. Unique Identifier : AIDSLINE /MED97433411
Moore JP; Trkola A; Dragic T; The Aaron Diamond AIDS Research Center, The Rockefeller University,; 455 First Avenue, New York, NY 10021, USA. jmoore@adarc.org

Abstract: HIV-1 enters its target cells by fusion at the plasma membrane. The primary cellular receptor for HIV is CD4, but this molecule is insufficient to permit viral fusion. During 1996, the necessary entry co-factors (co-receptors or second receptors) were identified as being members of the seven-transmembrane-spanning receptor family fusin: CXCR4 for T-tropic strains and CCR5, principally, for M-tropic strains. The co-receptor functions of these proteins are inhibited by their natural alpha- and beta-chemokine ligands.
Keywords: *HIV-1/PHYSIOLOGY *Receptors, CCR5/PHYSIOLOGY *Receptors, CXCR4/PHYSIOLOGY *Receptors, Virus/PHYSIOLOGYKWDhiv-1/physiologyKWDreceptors,ccr5/physiologyKWDreceptors,cxcr4/physiologyKWDreceptors,virus/physiology
Comment in: Curr Opin Immunol 1997 Aug;9(4):549-50
980130
M9811086

Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1998. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1998. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .