Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis [see comments]

Curr Opin Immunol. 1997 Aug;9(4):563-7. Unique Identifier : AIDSLINE /MED97433412
Grouard G; Clark EA; Regional Primate Research Center, Department of Microbiology,; University of Washington Medical Center, Seattle, WA 98195, USA.

Abstract: Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.
Keywords: *Dendritic Cells/IMMUNOLOGY *HIV/PHYSIOLOGY *HIV Infections/IMMUNOLOGYKWDdendriticcells/immunologyKWDhiv/physiologyKWDhivinfections/immunology
Comment in: Curr Opin Immunol 1997 Aug;9(4):549-50
980130
M9811085

Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1998. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1998. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .