1998

Advances in management of HIV and its complications. [videorecording]: Marshfield, WI : The Network, [1993] 1 videocassette (58 min.) : sd., col. with b&w ; 1/2 in Unique Identifier : AIDSLINE /MED9707870; Bernstein B; (Producer) Review advances in understanding pathogenesis of HIV. Discuss recent recommendations for antiretroviral therapy.
AIDS. 2nd ed. [computer file]: Philadelphia, PA : Current Medicine, c1996 1 computer laser optical disc : col. ; 4 3/4 in. + 1 guide (26 p.) (Atlas of infectious diseases on CD-ROM ; v. 1) Unique Identifier : AIDSLINE /MED9716934; Mildvan D
Le journal du sida. No 21 (oct. 1990)-: Paris : ARCAT-SIDA, [1990- v Unique Identifier : AIDSLINE /MED9425805
Survivre face au sida en Afrique.: Paris : Editions Karthala, c1994 314 p. : ill (Economie et developpement) Unique Identifier : AIDSLINE /MED9505617; Joinet B
Journal du sida. La lettre. No 1-: Paris : ARCAT-SIDA, [1994- v Unique Identifier : AIDSLINE /MED9615566
Maternite et seropositivite VIH : Hopital Hotel Dieu, Paris, 1994, colloque.: Paris : Arnette Blackwell, c1995 iv, 59 p Unique Identifier : AIDSLINE /MED9505605; Bensaid-Mrejen D
Sang contamine : priorites de l'Etat et decisions politiques.: Montpellier : Editions Espaces 34, c1995 236 p. : ill Unique Identifier : AIDSLINE /MED9708689; Roux J
Anthropologie et SIDA : bilan et perspectives.: Paris : Editions Karthala, c1996 381 p. : ill (Collection Medecines du monde) Unique Identifier : AIDSLINE /MED9707035; Benoist J
La depressione nel cancro e nell'infezione da HIV : cause, conseguenze e trattamento.: Milano, Italy : FrancoAngeli, c1997 182 p. : ill Unique Identifier : AIDSLINE /MED9711863; Grassi L
A world of silence : living with HIV in Matabeleland, Zimbabwe.: Amsterdam : Royal Tropical Institute, c1997 372 p. : ill Unique Identifier : AIDSLINE /MED9710730; Meursing K
HIV-Infekt : Pathogenese, Diagnostik, Therapie.: Berlin ; New York : Springer, c1997 viii, 181 p. : ill Unique Identifier : AIDSLINE /MED9710053; Brockmeyer NH
Pflege von Menschen mit HIV-Infektion und AIDS.: Bern ; Seattle : Huber, c1997 340 p. : ill Unique Identifier : AIDSLINE /MED9710114; Wierz V
HIV prevention and AIDS care in Africa : a district level approach.: Amsterdam : Royal Tropical Institute, c1997 400 p. : ill Unique Identifier : AIDSLINE /MED9712359; Ng'weshemi J
No place for borders : the HIV/AIDS epidemic and development in Asia and the Pacific.: New York : St. Martin's Press, 1997 xxii, 191 p. : ill Unique Identifier : AIDSLINE /MED9711456; Linge GJ; Porter D
Examining relationships between HIV/AIDS and tuberculosis programs in Title I eligible metropolitan areas. Office of Science and Epidemiology: [Rockville, Md.?] : U.S. Dept. of Health and Human Services, Health Resources and Services Administration, Bureau of Health Resources Development, Office of Science & Epidemiology, [1997] 35 p Unique Identifier : AIDSLINE /MED9712366
Viral sex : the nature of AIDS.: New York : Oxford University Press, 1997 xix, 260 p. : ill Unique Identifier : AIDSLINE /MED9711831; Goudsmit J
The AIDS cult : essays on the gay health crisis.: Provincetown, MA : Asklepios, 1997 223 p. : ill Unique Identifier : AIDSLINE /MED9714908; Lauritsen J; Young I
AIDS therapeutics in HIV disease. 2nd ed. / Adrian Palfreeman, Mike Youle, and Charles Farthing.: Chichester ; New York : J. Wiley & Sons, c1998 Unique Identifier : AIDSLINE /MED9716967; Palfreeman A; Youle M; Farthing CF
Progress in preventing AIDS? : dogma, dissent, and innovation : global perspectives.: Amityville, N.Y. : Baywood Pub. Co., c1998 vii, 359 p. : ill Unique Identifier : AIDSLINE /MED9708786; Buchanan DR; Cernada GP
Nutrients and foods in AIDS.: Boca Raton : CRC Press, 1998 (CRC series in modern nutrition) Unique Identifier : AIDSLINE /MED9717531; Watson RR
A deadly dance.: Newsweek. 1997 Sep 29;130(13):76-7. Unique Identifier : AIDSLINE /MED98010190; Peyser M
Consequences of adult HIV infection for outpatient morbidity and treatment costs: a prospective study in a factory clinic in Tanzania.: Health Policy Plan. 1997 Sep;12(3):234-9. Unique Identifier : AIDSLINE /MED97474978; Kikumbih SN; Isingo R; Boerma JT; National Institute for Medical Research, Mwanza, Tanzania.; Most studies of the medical costs of HIV infection focus on the terminal stage of this chronic illness when the patients have developed AIDS or severe HIV disease and in-patient care dominates. Data are also needed on the medical costs during the prolonged phase of HIV infection preceding severe terminal illness and t
Planning with PRA: HIV and STD in a Nepalese mountain community.: Health Policy Plan. 1997 Sep;12(3):253-61. Unique Identifier : AIDSLINE /MED97474981; Butcher K; Kievelitz U; Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), Pulchowk,; Nepal.; The application of Participatory Rural Appraisal methods (PRA) to the topic of sexual health enabled us to explore key factors concerning local people s perceptions regarding HIV/AIDS and STDs and to plan collectively to address the emerging issues. Conducting the process in a gender sensitive way enabled people to fe
The duty to warn third parties and AIDS in Canada.: Health Law Can. 1996 Feb;16(3):83-97. Unique Identifier : AIDSLINE /MED97465399; Sestito J
The ethics of deception in biomedical research.: Health Law Can. 1996 May;16(4):101-10. Unique Identifier : AIDSLINE /MED97465400; Sharpe G; Weisstub DN; McMaster University.
The care is getting there. Data show U.S. system is making people healthier [news]: Mod Healthc. 1997 Oct 6;27(40):58-60. Unique Identifier : AIDSLINE /MED98028280; Moore JD Jr
AIDS information needs: conceptual and content analyses of questions asked of AIDS information hotlines.: Health Educ Res. 1997 Sep;12(3):279-88. Unique Identifier : AIDSLINE /MED97480423; Kalichman SC; Belcher L; Department of Psychology, Georgia State University, Atlanta 30303,; USA.; Dissemination of accurate information about HIV is an essential element of national AIDS prevention strategies and AIDS telephone hotlines serve a vital function in providing such information. In this study, questions asked of two AIDS information hotlines were collected and examined to determine the AIDS information
Prenatal HIV screening in pregnant women: a medical-legal review.: Birth. 1997 Sep;24(3):165-72. Unique Identifier : AIDSLINE /MED98016908; Oldenettel D; Dye TD; Artal R; SUNY Health Science Center, Department of Obstetrics and Gynecology,; Syracuse 13202, USA.; Identifying pregnant women s human immunodeficiency virus (HIV) infection status provides them with the opportunity to seek appropriate treatment and to take measures to prevent vertical and horizontal transmission. Prenatal screening program options include targeting at-risk women, testing on a voluntary basis, or ma
Treatment of NOD diabetes with a novel peptide of the hsp60 molecule induces Th2-type antibodies.: J Autoimmun. 1997 Aug;10(4):323-9. Unique Identifier : AIDSLINE /MED97383171; Bockova J; Elias D; Cohen IR; Department of Immunology, The Weizmann Institute of Science, Rehovot,; 76100, Israel.; A peptide from the sequence of hsp60 molecule, designated p277, has been shown to be functionally involved in modulating the development of auto-immune diabetes in the NOD mouse: administration of p277 to NOD mice can arrest the diabetogenic autoimmune process, even when far advanced. Is p277 the only hsp60 peptide ab
Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines.: J Autoimmun. 1997 Aug;10(4):339-46. Unique Identifier : AIDSLINE /MED97383173; Polanski M; Melican NS; Zhang J; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital and; Harvard Medical School, Boston, MA, 02115, USA.; Oral administration of antigen leads to systemic immune unresponsiveness. Low dose oral tolerance generates regulatory cells which, when triggered in an antigen-specific manner, suppress inflammatory responses. We have previously shown that oral administration of an organ-specific antigen, porcine insulin, protects ag
TCR vbeta usage of TSH receptor-specific CD4+ T cells in Graves' disease patients and healthy humans.: J Autoimmun. 1997 Oct;10(5):479-89. Unique Identifier : AIDSLINE /MED98018742; Raju R; Navaneetham D; Kellermann SA; Freeman SL; Morris JC; McCormick DJ; Conti-Fine BM; Department of Biochemistry, University of Minnesota, St Paul, MN; 55108, USA.; Healthy humans have CD4+ T cells specific for self-components. Since autoreactive T cells in autoimmune patients may use a limited number of TCR V-region genes, we investigated here whether this also occurs for the potentially autoreactive CD4+ cells present in healthy persons. We studied CD4+ cells specific for human
The role of virologic and immunologic factors in mother-to-child transmission of HIV-1.: Am J Reprod Immunol. 1997 Sep;38(3):197-200. Unique Identifier : AIDSLINE /MED97466052; Colognesi C; Halapi E; Jansson M; Hodara V; Steuer G; Tresoldi E; Leitner T; Scarlatti G; Unit of Immunobiology of HIV, DIBIT, San Raffaele Scientific; Institute, Milano, Italy.; PROBLEM: More than 90% of human immunodeficiency virus type 1 HIV-1) infection in children is acquired by mother-to-child transmission. However, infection of the child occurs in between 14 and 35% of cases. METHOD OF STUDY: To understand the mechanisms involved in HIV-1 transmission, we have investigated the antigenic
HIV transmission via breastfeeding: reflections on the issues [editorial]: J Hum Lact. 1997 Sep;13(3):179-81. Unique Identifier : AIDSLINE /MED98000553; Nommsen-Rivers L; Heinig MJ
Characterization of a putative retroviral env-related human protein.: Pathobiology. 1997;65(3):123-8. Unique Identifier : AIDSLINE /MED97455420; Turbeville MA; Rhodes JC; Hyams DM; Distler CM; Steele PE; Department of Pathology, University of Cincinnati College of Medicine,; Ohio, USA.; In this study, we developed a rabbit polyclonal antibody to a fusion protein containing the envelope (env) transmembrane (TM) region from the human endogenous retroviral family, HERV-E. We used this reagent to document the expression of TM-related protein by Western blot in endothelial, colon and prostate carcinoma an
Targeting IL-12, the key cytokine driving Th1-mediated autoimmune diseases.: Chem Immunol. 1997;68:175-97. Unique Identifier : AIDSLINE /MED97469800; Adorini L; Aloisi F; Galbiati F; Gately MK; Gregori S; Penna G; Ria F; Smiroldo S; Trembleau S; Roche Milano Ricerche, Milano, Italia. Luciano.Adorini@Roche.com
Regulation of IL-12 receptor expression in early T-helper responses implies two phases of Th1 differentiation: capacitance and development.: Chem Immunol. 1997;68:54-69. Unique Identifier : AIDSLINE /MED97469794; Murphy KM; Murphy TL; Szabo SJ; Jacobson NG; Guler ML; Gorham JD; Gubler U; Department of Pathology, Washington University School of Medicine, St.; Louis, Mo., USA.
Web alert. Immunity to infection. Genetic effects on immunity. HIV.: Curr Opin Immunol. 1997 Aug;9(4):451. Unique Identifier : AIDSLINE /MED97433394; Greaves DR; Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1; 3RE, UK. david.greaves@path.ox.ac.uk
The role of CD1 molecules in immune responses to infection [see comments]: Curr Opin Immunol. 1997 Aug;9(4):456-61. Unique Identifier : AIDSLINE /MED97433396; Maher JK; Kronenberg M; Department of Microbiology, Molecular Biology Institute University of; California at Los Angeles, Los Angeles, CA 90095, USA. juli@liai.org; Recent work on CD1 molecules has demonstrated that human CD1b and a lipoglycan from mycobacteria that CD1b presents colocalize to late endosomes. Presentation of this lipoglycan by CD1b requires antigen uptake via the mannose receptor. CD8(+) CD1-restricted T cells can decrease the load of intracellular mycobacteria b
Interference with antigen processing by viruses [see comments]: Curr Opin Immunol. 1997 Aug;9(4):470-6. Unique Identifier : AIDSLINE /MED97433398; Hengel H; Koszinowski UH; Max von Pettenkofer-Institut, Lehrstuhl Virologie, Genzentrum, Ludwig; Maximilians-Universitat Munchen, Feodor-Lynen-Strasse 25, 81377,; Munchen, Germany. hengel@lmb.uni-muenchen.de; Viruses that establish persistent infections in their host, such as herpesviruses, adenoviruses or HIV, express proteins designed to pre-empt or evade recognition and elimination by MHC class I restricted CD8+ T lymphocytes. Notable discoveries during the annual period of review have demonstrated that, in principle, e
The impact of host genetics on susceptibility to human infectious diseases.: Curr Opin Immunol. 1997 Aug;9(4):509-16. Unique Identifier : AIDSLINE /MED97433404; Abel L; Dessein AJ; Institut National de la Sante Et de la Recherche Medicale,; Mathematical and Statistical Modeling in Biology and Medicine, Centre; Hospitalo-Universitaire Pitie-Salpetriere, Paris, France. abel@biomath; The development of genetic epidemiology methods using recent human genetic mapping information, together with the growing availability of candidate genes, has led to major advances in the identification of host genes involved in human infectious diseases. Within the past year, highlights include the mapping of a locus
Recombinant viruses as vaccines and immunological tools [see comments]: Curr Opin Immunol. 1997 Aug;9(4):517-24. Unique Identifier : AIDSLINE /MED97433405; Rolph MS; Ramshaw IA; Department of Immunology, Max Planck Institute for Infection Biology,; Monbijoustrasse 2, D-10117, Berlin, Germany. rolph@mpiib-berlin.mpg.de; Recombinant viruses have been investigated as candidate vaccines, and have also been used extensively as immunological tools. Recent advances in this area include the following: the construction and testing of a recombinant simian immunodeficiency virus encoding human interferon-gamma; the development of new vectors s
HIV. A clever hijacker of the immune system [editorial; comment]: Curr Opin Immunol. 1997 Aug;9(4):549-50. Unique Identifier : AIDSLINE /MED97433410; Bolognesi DP; Duke University Medical Center, Center for AIDS Research, Department; of Surgery, Box 2926, Durham, NC 27710-2926, USA.
Co-receptors for HIV-1 entry [see comments]: Curr Opin Immunol. 1997 Aug;9(4):551-62. Unique Identifier : AIDSLINE /MED97433411; Moore JP; Trkola A; Dragic T; The Aaron Diamond AIDS Research Center, The Rockefeller University,; 455 First Avenue, New York, NY 10021, USA. jmoore@adarc.org; HIV-1 enters its target cells by fusion at the plasma membrane. The primary cellular receptor for HIV is CD4, but this molecule is insufficient to permit viral fusion. During 1996, the necessary entry co-factors (co-receptors or second receptors) were identified as being members of the seven-transmembrane-spanning rec
Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis [see comments]: Curr Opin Immunol. 1997 Aug;9(4):563-7. Unique Identifier : AIDSLINE /MED97433412; Grouard G; Clark EA; Regional Primate Research Center, Department of Microbiology,; University of Washington Medical Center, Seattle, WA 98195, USA.; Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus,
Immune reconstitution in HIV infection [see comments]: Curr Opin Immunol. 1997 Aug;9(4):568-72. Unique Identifier : AIDSLINE /MED97433413; Emery S; Lane HC; National Centre in HIV Epidemiology and Clinical Research, University; of New South Wales, 2nd floor, 376 Victoria Street, Darlinghurst,; Sydney, NSW 2010, Australia. semery@nchecr.unsw.edu.au; Progressive immune deficiency arising during HIV disease reflects the continual degradation and the ultimate deletion of immune specificites defined by the CD4(+) T lymphocyte repertoire. Recent evidence suggests that improvements in the immune function of patients with HIV who receive therapy primarily reflects the e
Bibliography. Current world literature. HIV.: Curr Opin Immunol. 1997 Aug;9(4):602-21. Unique Identifier : AIDSLINE /MED98028252
Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centres. Federation National des Centres de Lutte contre le SIDA.: AIDS. 1997 Oct;11(12):F101-5. Unique Identifier : AIDSLINE /MED98000108; Mouton Y; Alfandari S; Valette M; Cartier F; Dellamonica P; Humbert G; Lang JM; Massip P; Mechali D; Leclercq P; Modai J; Portier H; Service des Maladies Infectieuses, Centre Hospitalier, Tourcoing,; France.; OBJECTIVE: To assess the clinical and economic consequences of the use of protease inhibitors in the treatment of HIV infection. DESIGN: Multicentric, observational, retrospective cohort study. SETTING: Ten AIDS reference centres in
Protease inhibitor therapy in children with perinatally acquired HIV infection.: AIDS. 1997 Oct;11(12):F107-11. Unique Identifier : AIDSLINE /MED98000109; Rutstein RM; Feingold A; Meislich D; Word B; Rudy B; Division of General Pediatrics, Children's Hospital of Philadelphia,; Pennsylvania 19104, USA.; OBJECTIVE: To review the short-term response and safety of protease inhibitor therapy in HIV-infected children. DESIGN: Retrospective chart review of open-label protease inhibitor-containing combination therapy . SETTING: Two urban pediatric HIV centers. PATIENTS: Twent
The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Cote d'Ivoire.: AIDS. 1997 Oct;11(12):F85-93. Unique Identifier : AIDSLINE /MED98000106; Ghys PD; Fransen K; Diallo MO; Ettiegne-Traore V; Coulibaly IM; Yeboue KM; Kalish ML; Maurice C; Whitaker JP; Greenberg AE; Laga M; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; OBJECTIVE: To measure the frequency and associated factors of cervicovaginal HIV shedding and to determine the impact of sexually transmitted disease (STD) treatment on HIV shedding. DESIGN: Cross-sectional study with 1-week follow-up. SETTING: Confidential clinic for female sex workers in Abidjan,
Toxicity, efficacy, plasma drug concentrations and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir. Swiss HIV Cohort Study.: AIDS. 1997 Oct;11(12):F95-9. Unique Identifier : AIDSLINE /MED98000107; Lorenzi P; Yerly S; Abderrakim K; Fathi M; Rutschmann OT; von Overbeck J; Leduc D; Perrin L; Hirschel B; Division of Infectious Diseases, University Hospital, Geneva,; Switzerland.; OBJECTIVE: To assess the safety, efficacy and plasma drug levels of the combination of ritonavir plus saquinavir for the treatment of advanced HIV infection. DESIGN: Multicentre pilot study. PATIENTS: Eighteen protease inhibitor-naive patients, with i
The influence of MT-2 tropism on the prognostic implications of the delta32 deletion in the CCR-5 gene.: AIDS. 1997 Oct;11(12):1415-9. Unique Identifier : AIDSLINE /MED98000110; Bratt G; Sandstrom E; Albert J; Samson M; Wahren B; Gay Men's Health Clinic, the Department of Dermatovenereology,; Stockholm Soder Hospital, Sweden.; BACKGROUND: Long-term non-progression in HIV-1-infected patients has been reported to be associated with a 32 base-pair deletion delta32) in one CCR-5 allele. The normal gene product acts as a coreceptor for HIV cell entry and is essential for infection of cells by non-syncytium-inducing and MT-2-negative HIV-1 strain
HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region.: AIDS. 1997 Oct;11(12):1421-31. Unique Identifier : AIDSLINE /MED98000111; Chang HC; Samaniego F; Nair BC; Buonaguro L; Ensoli B; Laboratory of Tumor Cell Biology, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland, USA.; OBJECTIVE: To analyze the mechanisms of release and the extracellular fate of the HIV-1 Tat protein and to determine the Tat domain binding to the extracellular matrix. DESIGN AND METHODS: Release of Tat was studied by pulse-chase experiments with Tat-transfected COS-1 cells in the presence or absence of different ser
Development of genetic vaccines for pathogenic genes: construction of attenuated vif DNA immunization cassettes.: AIDS. 1997 Oct;11(12):1433-44. Unique Identifier : AIDSLINE /MED98000112; Ayyavoo V; Nagashunmugam T; Boyer J; Mahalingam S; Fernandes LS; Le P; Lin J; Nguyen C; Chattargoon M; Goedert JJ; Friedman H; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; OBJECTIVE: To develop a putative immunization cassette using HIV-1 vif accessory gene derived from HIV-1 clinical specimens as a component of a DNA vaccine for HIV-1. METHODS: vif genes were cloned from HIV-1-infected patients and the sequence variation present within the patients was analyzed. Prototypic genetic vari
HIV infection alters the production of both type 1 and 2 cytokines but does not induce a polarized type 1 or 2 state.: AIDS. 1997 Oct;11(12):1445-52. Unique Identifier : AIDSLINE /MED98000113; Fakoya A; Matear PM; Filley E; Rook GA; Stanford J; Gilson RJ; Beecham N; Weller IV; Vyakarnam A; Department of Sexually Transmitted Diseases, University College London; Medical School, UK.; OBJECTIVE: To test the T-helper (TH)1/TH2 cytokine paradigm in HIV infection. DESIGN AND METHODS: Cytokine profiles in two separate studies of HIV patients and controls are presented: (i) a longitudinal study of HIV patients with CD4 counts > 500 x 10(6)/l tested at three timepoints compared with controls; (ii) a blin
Effect of recombinant human granulocyte-macrophage colony-stimulating factor on HIV-related leukopenia: a randomized, controlled clinical study.: AIDS. 1997 Oct;11(12):1453-61. Unique Identifier : AIDSLINE /MED98000114; Barbaro G; Di Lorenzo G; Grisorio B; Soldini M; Barbarini G; Department of Emergency Medicine, La Sapienza University, Rome, Italy.; OBJECTIVE: To assess the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on white blood cell (WBC) count and on the rate of opportunistic infections in a large and selected population of leukopenic HIV-positive patients compared with non-treated controls. DESIGN: Open-label, randomized, comparative
Liposomal amphotericin B (AmBisome) compared with amphotericin B both followed by oral fluconazole in the treatment of AIDS-associated cryptococcal meningitis.: AIDS. 1997 Oct;11(12):1463-71. Unique Identifier : AIDSLINE /MED98000115; Leenders AC; Reiss P; Portegies P; Clezy K; Hop WC; Hoy J; Borleffs JC; Allworth T; Kauffmann RH; Jones P; Kroon FP; Verbrugh HA; de Marie S; University Hospital Rotterdam, The Netherlands.; OBJECTIVE: Amphotericin B deoxycholate initial therapy and fluconazole maintenance therapy is the treatment of choice for AIDS-associated cryptococcal meningitis. However, the administration of amphotericin B is associated with considerable toxicity. A potential strategy for reducing the toxicity and increasing the th
Susceptibility to levofloxacin of Myocobacterium tuberculosis isolates from patients with HIV-related tuberculosis and characterization of a strain with levofloxacin monoresistance. Community Programs for Clinical Research on AIDS 019 and the AIDS Clinical Trials Group 222 Protocol Team.: AIDS. 1997 Oct;11(12):1473-8. Unique Identifier : AIDSLINE /MED98000116; Perlman DC; El Sadr WM; Heifets LB; Nelson ET; Matts JP; Chirgwin K; Salomon N; Telzak EE; Klein O; Kreiswirth BN; Musser JM; Hafner R; Beth Israel Medical Center, New York, NY 10003, USA.; OBJECTIVE: To characterize the susceptibility to levofloxacin of clinical isolates of Mycobacterium tuberculosis (MTB) obtained from patients with HIV-related tuberculosis and to characterize the molecular genetics of levofloxacin resistance. DESIGN AND METHODS: Isolates from culture-positive patients in a
Increased losses of CD4+CD45RA+ cells in late stages of HIV infection is related to increased risk of death: evidence from a cohort of 347 HIV-infected individuals.: AIDS. 1997 Oct;11(12):1479-85. Unique Identifier : AIDSLINE /MED98000117; Ullum H; Lepri AC; Victor J; Skinhoj P; Phillips AN; Pedersen BK; Department of Infectious Diseases, Rhima Centre, Rigshospitalet,; Copenhagen, Denmark.; OBJECTIVE: To examine changes in the distribution of CD4+CD45RA+ naive) and CD4+CD45RO+ (memory) lymphocytes in various stages of HIV infection and the effect of these changes on disease progression. DESIGN AND METHODS: Expression of CD45RA+ and CD45RO+ on CD4+ lymphocytes was analysed by flow cytometry in a prospecti
Longitudinal evaluation of severely anemic children in Kenya: the effect of transfusion on mortality and hematologic recovery.: AIDS. 1997 Oct;11(12):1487-94. Unique Identifier : AIDSLINE /MED98000118; Lackritz EM; Hightower AW; Zucker JR; Ruebush TK 2nd; Onudi CO; Steketee RW; Were JB; Patrick E; Campbell CC; Division of Parasitic Diseases, National Center for Infectious; Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; OBJECTIVE: To determine the effect of transfusion on hematologic recovery and mortality among severely anemic children during and after hospitalization in rural Kenya . DESIGN: Prospective cohort. METHODS: We collected clinical and laboratory information on all severely anemic childr
Actual versus perceived HIV status, sexual behaviors and predictors of unprotected sex among young gay and bisexual men who identify as HIV-negative, HIV-positive and untested.: AIDS. 1997 Oct;11(12):1495-502. Unique Identifier : AIDSLINE /MED98000119; Hays RB; Paul J; Ekstrand M; Kegeles SM; Stall R; Coates TJ; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.; OBJECTIVES: To compare the prevalence and predictors of HIV sexual risk behavior among young gay and bisexual men who perceived themselves to be HIV-negative, HIV-positive, or who were untested. DESIGN: Population-based sample of young gay and bisexual men. METHODS: Using multi-stage probability sampling, 408 gay and
Increasing diversity of HIV-1M serotypes in French blood donors over a 10-year period (1985-1995). Retrovirus Study Group of the French Society of Blood Transfusion.: AIDS. 1997 Oct;11(12):1503-8. Unique Identifier : AIDSLINE /MED98000120; Barin F; Courouce AM; Pillonel J; Buzelay L; Laboratoire de Virologie, Equipe Postulante Centre National de la; Recherche Scientifique 117, Centre Hospitalier Universitaire,; Bretonneau, Tours, France.; OBJECTIVE: Phylogenetic analysis of gene sequences of HIV-1 has led to the classification of isolates into a major group (M) of viruses, itself divided into subtypes (A to I), and a minor group O) of rare isolates. Subtype B viruses are the most prevalent in Western countries but little is known about the dynamics of
CD4 surveillance in Scotland: perspectives on severe HIV-related immunodeficiency. CD4 Collaborative Group.: AIDS. 1997 Oct;11(12):1509-17. Unique Identifier : AIDSLINE /MED98000121; OBJECTIVE: To analyse factors that influence the following: the square root of first CD4 cell count; which individuals are severely immunodeficient at or before the start of monitoring; progression from the date of the earlier of two consecutive CD4 counts
Knowledge of HIV transmission and sexual behavior of college students in Pune, India [letter]: AIDS. 1997 Oct;11(12):1519-20. Unique Identifier : AIDSLINE /MED98000122; Singh U; Porterfield D; Thilakavathi S; Shepard M; Mawar N; Divekar AD; Bollinger R
Nimodipine plus zidovudine versus zidovudine alone in the treatment of HIV-1-associated cognitive deficits [letter]: AIDS. 1997 Oct;11(12):1520-1. Unique Identifier : AIDSLINE /MED98000123; Galgani S; Balestra P; Narciso P; Tozzi V; Sette P; Pau F; Visco G
Evaluation of contrast-enhancing brain lesions in AIDS patients by means of Epstein-Barr virus detection in cerebrospinal fluid and 201thallium single photon emission tomography [letter]: AIDS. 1997 Oct;11(12):1522-3. Unique Identifier : AIDSLINE /MED98000124; Castagna A; Cinque P; d'Amico A; Messa C; Fazio F; Lazzarin A
Stavudine, lamivudine and indinavir in children with advanced HIV-1 infection: preliminary experience [letter]: AIDS. 1997 Oct;11(12):1523-5. Unique Identifier : AIDSLINE /MED98000125; Monpoux F; Sirvent N; Cottalorda J; Mariani R; Lefbvre JC
Nonoxynol-9 as a xenobiotic with endocrine activity [letter]: AIDS. 1997 Oct;11(12):1525-6. Unique Identifier : AIDSLINE /MED98000126; Bourinbaiar AS
Regression of progressive multifocal encephalopathy with highly active antiretroviral therapy [letter]: AIDS. 1997 Oct;11(12):1526-7. Unique Identifier : AIDSLINE /MED98000127; Baqi M; Kucharczyk W; Walmsley SL
Drug resistance mutations as predictors of phenotypic zidovudine resistance in HIV-1 infection [letter]: AIDS. 1997 Oct;11(12):1528-9. Unique Identifier : AIDSLINE /MED98000128; Chen P; Schmit JC; Arendt V; Plesseria JM; Lambert C; Fontaine E; Kirpach P; Ninove D; Schneider F; Hemmer R
Diagnosis of toxoplasmic encephalitis in HIV-infected patients [letter]: AIDS. 1997 Oct;11(12):1529-30. Unique Identifier : AIDSLINE /MED98000129; Gianotti N; Cinque P; Castagna A; Novati R; Moro M; Lazzarin A
Human herpesvirus DNA in prostate and semen from HIV-negative individuals in Italy [letter]: AIDS. 1997 Oct;11(12):1530-2. Unique Identifier : AIDSLINE /MED98000130; Monini P; Howard MR; Rimessi P; de Lellis L; Schulz TF; Cassai E
Large proportion of non-B HIV-1 subtypes and presence of zidovudine resistance mutations among German seroconvertors [letter]: AIDS. 1997 Oct;11(12):1532-3. Unique Identifier : AIDSLINE /MED98000131; Dietrich U; Ruppach H; Gehring S; Knechten H; Knickmann M; Jager H; Wolf E; Husak R; Orfanos CE; Brede HD; Rubsamen-Waigmann H; von Briesen H
A research agenda for AIDS prevention in the developing world.: AIDS. 1997 Sep;11 Suppl 1:S1-4. Unique Identifier : AIDSLINE /MED98025843; Hearst N; Mandel JS; University of California, San Francisco 94105, USA.; BACKGROUND: In the developing world, HIV is spreading in many epidemiologic patterns, ranging from slow spread in limited segments of the population to exponential growth to mature epidemics. These differences are superimposed on widely varying cultures and patterns of behavior, creating unique challenges for preventi
Rapid HIV testing and counseling for voluntary testing centers in Africa.: AIDS. 1997 Sep;11 Suppl 1:S103-10. Unique Identifier : AIDSLINE /MED98025856; McKenna SL; Muyinda GK; Roth D; Mwali M; Ng'andu N; Myrick A; Luo C; Priddy FH; Hall VM; von Lieven AA; Sabatino JR; Mark K; Allen SA; Project San Francisco, Lusaka, Zambia.; OBJECTIVE: Voluntary HIV testing and counseling (VTC) has been shown to reduce the incidence of HIV in cohabiting couples who now represent the majority of new infections in many African cities. Community and client perceptions of a 1-day voluntary testing and counseling program in Lusaka,
Traditional Balinese youth groups as a venue for prevention of AIDS and other sexually transmitted diseases.: AIDS. 1997 Sep;11 Suppl 1:S111-9. Unique Identifier : AIDSLINE /MED98025857; Merati TP; Ekstrand ML; Hudes ES; Suarmiartha E; Mandel JS; Udayana University AIDS Working Group and Citra Usadha Indonesia; Foundation, Bali, Indonesia.; OBJECTIVES: Our aims were to assess the feasibility of conducting peer-led educational interventions against AIDS and other sexually transmitted diseases (STDs) through traditional Balinese youth groups and to gather information on sexual risk-taking and its correlates among Balinese youth. DESIGN: A cross-sectional s
Evaluating an AIDS sexual risk reduction program for young adults in public night schools in Sao Paulo, Brazil.: AIDS. 1997 Sep;11 Suppl 1:S121-7. Unique Identifier : AIDSLINE /MED98025858; Antunes MC; Stall RD; Paiva V; Peres CA; Paul J; Hudes M; Hearst N; AIDS Prevention Studies Nucleus (NEPAIDS), Institute of Psychology,; University of Sao Paulo, Brazil.; OBJECTIVES: To describe sexual risk for HIV infection among adult night school students in Sao Paulo, Brazil , and to evaluate the effect of an HIV/AIDS prevention workshop to reduce sexual risk. SUBJECTS AND METHODS: A longitudinal study was conducted among four demographically sim
Truck drivers in Brazil: prevalence of HIV and other sexually transmitted diseases, risk behavior and potential for spread of infection.: AIDS. 1997 Sep;11 Suppl 1:S15-9. Unique Identifier : AIDSLINE /MED98025845; Lacerda R; Gravato N; McFarland W; Rutherford G; Iskrant K; Stall R; Hearst N; ASPPE-Associacao Santista de Pesquisa Prevencao e Educacao em DST/AIDS; and Secretaria de Higiene e Saude de Santos, Brazil.; OBJECTIVES: To determine the prevalence of HIV and syphilis and related risk behavior in a sample of truck drivers in Santos, Brazil . SUBJECTS AND METHODS: A cross-sectional study was performed of 300 male truck drivers recruited in the port of Santos, Brazil, including a face-to-f
Adolescent sexual behavior along the Trans-Africa Highway in Kenya.: AIDS. 1997 Sep;11 Suppl 1:S21-6. Unique Identifier : AIDSLINE /MED98025846; Nzyuko S; Lurie P; McFarland W; Leyden W; Nyamwaya D; Mandel JS; African Medical and Research Foundation, Nairobi, Kenya.; OBJECTIVE: To describe the demographic characteristics and HIV-related risk behaviors of adolescents frequenting truck stops along the Trans-Africa Highway in Kenya . METHODS: A cross-sectional study of 200 adolescents (52% female) aged 15-19 years was conducted at the Malaba, Sachan
Extremely low awareness of AIDS, sexually transmitted diseases and condoms among Dai ethnic villagers in Yunnan province, China.: AIDS. 1997 Sep;11 Suppl 1:S27-34. Unique Identifier : AIDSLINE /MED98025847; Liao S; Choi KH; Zhang K; Hall TL; Qi B; Deng Y; Fang J; Yang Y; Kay J; Qin Z; Liu W; Mandel JS; Department of Epidemiology, Institute of Medical Sciences, Peking; Union Medical College and Chinese Academy of Medical Science, Beijing.; OBJECTIVE: To assess the awareness of AIDS, other sexually transmitted diseases (STDs), condoms, sources of health information and HIV-related societal risks among Dai villagers in southern Yunnan Province, China . SUBJECTS AND METHODS: In November-December 1994, a cross-sectional de
Risk behavior and HIV seroprevalence among injecting drug users in Rio de Janeiro, Brazil.: AIDS. 1997 Sep;11 Suppl 1:S35-42. Unique Identifier : AIDSLINE /MED98025848; Telles PR; Bastos FI; Guydish J; Inciardi JA; Surratt HL; Pearl M; Hearst N; Nucleo de Estudos e Pesquisa em Atencao ao uso de Drogas, State; University of Rio de Janeiro, Brazil.; OBJECTIVE: To characterize HIV seroprevalence and risk behavior among injecting drug users (IDUs) in Rio de Janeiro, Brazil , between 1990 and 1996. DESIGN: We report data from three separate cross-sectional samples of IDUs in Rio de Janeiro: the World H
HIV risk behavioral surveillance in Bangkok, Thailand: sexual behavior trends among eight population groups.: AIDS. 1997 Sep;11 Suppl 1:S43-51. Unique Identifier : AIDSLINE /MED98025849; Mills S; Benjarattanaporn P; Bennett A; Pattalung RN; Sundhagul D; Trongsawad P; Gregorich SE; Hearst N; Mandel JS; AIDS Control and Prevention Project, Family Health International,; Bangkok, Thailand.; OBJECTIVE: To assess trends in HIV risk behaviors over a 3-year period in eight population groups in Bangkok, Thailand . DESIGN AND SUBJECTS: Using a repeated cross-sectional survey design with a structured questionnaire, we collected five sets of self-reported sexual behavior dat
Rising HIV infection rates in Ho Chi Minh City herald emerging AIDS epidemic in Vietnam.: AIDS. 1997 Sep;11 Suppl 1:S5-13. Unique Identifier : AIDSLINE /MED98025844; Lindan CP; Lieu TX; Giang LT; Lap VD; Thuc NV; Thinh T; Lurie P; Mandel JS; University of California, San Francisco 94025, USA.; OBJECTIVE: To describe the epidemiology of HIV in Ho Chi Minh City in the context of current surveillance data from Vietnam . METHODS: Since the late 1980s, HIV surveillance data have been collected in Ho Chi Minh City from centers for the treatment of venereal disease and tubercul
The correlates of safer behavior among homosexually active men in Lima.: AIDS. 1997 Sep;11 Suppl 1:S53-9. Unique Identifier : AIDSLINE /MED98025850; Caceres CF; Rosasco AM; Institute of Population Studies, Cayetano Heredia University, Lima,; Peru.; OBJECTIVE: To describe sexual behavior patterns and identify psychosocial and situational correlates of safer practices among men who have sex with other men in Lima. DESIGN: A cross-sectional survey. Subjects and methods: In 1992, 223 mostly young, working- and middle-class homosexually active men in Lima, who report
Condom use with casual partners by men in Kampala, Uganda.: AIDS. 1997 Sep;11 Suppl 1:S61-6. Unique Identifier : AIDSLINE /MED98025851; Kamya M; McFarland W; Hudes ES; Ssali A; Busuulwa R; Hearst N; Department of Medicine, Makerere University, Kampala, Uganda.; OBJECTIVE: To estimate the prevalence and correlates of condom use with casual sex partners by men in urban Uganda and to identify barriers to condom use that are amenable to intervention. DESIGN: Cross-sectional, door-to-door survey of men residing in a poor area of Kampala, Ugand
Young people and the structure of sexual risks in Lima.: AIDS. 1997 Sep;11 Suppl 1:S67-77. Unique Identifier : AIDSLINE /MED98025852; Caceres CF; Marin BV; Hudes ES; Reingold AL; Rosasco AM; Institute of Population Studies, Cayetano Heredia University, Lima,; Peru.; OBJECTIVES: (1) To describe psychosocial variables related to sexual activity and the prevalence of contextual factors (e.g. coercion, paid sex and drug/alcohol use) and various sexual experiences among young men and women in Lima; and (2) to assess the relationship between psychosocial, contextual and behavioral fact
HIV/AIDS-related attitudes and practices of hospital-based health workers in Kampala, Uganda.: AIDS. 1997 Sep;11 Suppl 1:S79-85. Unique Identifier : AIDSLINE /MED98025853; Mungherera M; van der Straten A; Hall TL; Faigeles B; Fowler G; Mandel JS; Butabika Mental Hospital, Kampala, Uganda.; OBJECTIVE: To assess HIV/AIDS-related attitudes and practices of hospital-based health workers in Kampala, Uganda . METHODS: A cross-sectional study was conducted in Mulago Hospital, the main national referral hospital in Uganda. A total of 155 physicians and nurses completed a brie
Men with sexually transmitted diseases in Bangkok: where do they go for treatment and why?: AIDS. 1997 Sep;11 Suppl 1:S87-95. Unique Identifier : AIDSLINE /MED98025854; Benjarattanaporn P; Lindan CP; Mills S; Barclay J; Bennett A; Mugrditchian D; Mandel JS; Pongswatanakulsiri P; Warnnissorn T; AIDS Control and Prevention Project, Family Health International,; Bangkok, Thailand.; OBJECTIVES: To describe and identify predictors of health-care seeking behavior among men with sexually transmitted diseases STDs) in Bangkok, Thailand . DESIGN: Cross-sectional survey. METHODS: Men presenting with STDs were recruited from government clinics (n = 101), private cli
Risk factors for prevalent and incident HIV infection in a cohort of volunteer blood donors in Harare, Zimbabwe: implications for blood safety.: AIDS. 1997 Sep;11 Suppl 1:S97-102. Unique Identifier : AIDSLINE /MED98025855; McFarland W; Mvere D; Katzenstein D; University of California, San Francisco 94105, USA.; OBJECTIVES: To compare risk factors for HIV seropositivity with risk factors for HIV seroconversion in a population of volunteer blood donors in Harare, Zimbabwe , and to assess the impact of risk factor exclusion strategies on the safety of the blood supply. DESIGN: A secondary a
Purulent meningitis due to Rhodococcus equi. A case of posttraumatic infection.: APMIS. 1997 Sep;105(9):705-7. Unique Identifier : AIDSLINE /MED98011289; Tunger A; Ozkan F; Vardar F; Burhanoglu D; Ozinel MA; Tokbas A; Department of Microbiology and Clinical Microbiology, Ege University; Medical Faculty, Bornova, Izmir, Turkey.; Opportunistic infections due to Rhodococcus equi have been increasingly reported in the immunocompromised population, especially in patients with AIDS. In this report, we present an unusual case of purulent meningitis that developed in an immunocompetent six-year-old child through direct inoculation of R. equi.
Transduction potential of human retroviruses in highly proliferating small-cell lung cancer cells as well as non-proliferating hematopoietic stem cells.: APMIS. 1997 Sep;105(9):723-9. Unique Identifier : AIDSLINE /MED98011292; Hansen JE; Gram GJ; Nielsen SD; Sorensen A; Jensen PB; Sehested M; Nielsen JO; Rorth M; Department 144, Hvidovre Hospital, Denmark.; Direct gene transfer to solid tissues or metastatic cancer cells requires vectors capable of in vivo transduction to specific cells. The predominant retroviral vectors of murine origin are inactivated by human complement, which precludes their use in vivo. Such inactivation does not take place with vectors based on hu
Safety profile of phase I and II preventive HIV type 1 envelope vaccination: experience of the NIAID AIDS Vaccine Evaluation Group.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1163-77. Unique Identifier : AIDSLINE /MED97454208; Keefer MC; Wolff M; Gorse GJ; Graham BS; Corey L; Clements-Mann ML; Verani-Ketter N; Erb S; Smith CM; Belshe RB; Wagner LJ; McElrath MJ; Schwartz DH; Fast P; University of Rochester School of Medicine and Dentistry, New York; 14642, USA.; The NIAID-sponsored AIDS Vaccine Evaluation Group was established in 1988 to perform phase I/II clinical trials with candidate preventive HIV-1 vaccines. This report includes safety data from 1398 HIV-negative, healthy volunteers who were enrolled into 25 phase I and 1 phase H multicentered, randomized, double-blind s
High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1179-85. Unique Identifier : AIDSLINE /MED97454209; Hocini H; Belec L; Iscaki S; Garin B; Pillot J; Becquart P; Bomsel M; Unite INSERM U430 (Immunopathologie Humaine), Hopital Broussais,; Paris, France. hakim.hocini@brs.ap-hop-paris.fr; The IgG and secretory IgA (S-IgA) responses to the HIV-1 envelope gp160 antigen) were analyzed in the colostrum (Col) and in the cervicovaginal fluid (CVF) of HIV-l-infected women. We show IgG antibodies (Abs) to the recombinant gp160 to be predominant as compared with the corresponding S-IgA isotype. The low level of
Induction of mucosal and systemic responses against human immunodeficiency virus type 1 glycoprotein 120 in mice after oral immunization with a single dose of a Salmonella-HIV vector.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1187-94. Unique Identifier : AIDSLINE /MED97454210; Wu S; Pascual DW; Lewis GK; Hone DM; Division of Infectious Diseases and Gastroenterology, School of; Medicine, Johns Hopkins University, Baltimore, Maryland 21202, USA.; Previous studies from our group showed that a Salmonella-HIV vector vaccine that expressed recombinant HIV-1 envelope protein gp120 stably in the vector cytoplasm elicited type 1 helper T cell (Th1) responses to gp120. Despite the promise of such vaccines, a major limitation in their use was that multiple immunization
An HIV type 1 epidemic among injecting drug users in the former Soviet Union caused by a homogeneous subtype A strain.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1195-201. Unique Identifier : AIDSLINE /MED97454211; Bobkov A; Cheingsong-Popov R; Selimova L; Ladnaya N; Kazennova E; Kravchenko A; Fedotov E; Saukhat S; Zverev S; Pokrovsky V; Weber J; The D.I. Ivanovsky Institute of Virology, Moscow, Russia.; Epidemiological data have demonstrated rapid growth of HIV-1 infections among injecting drug users (IDUs) in the Ukraine and Russia , during 1996. Here we describe the results of genetic analysis of isolates derived from 12 HIV-1-infected IDUs i
Membrane fusion induced by the HIV type 1 fusion peptide: modulation by factors affecting glycoprotein 41 activity and potential anti-HIV compounds.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1203-11. Unique Identifier : AIDSLINE /MED97454212; Pereira FB; Goni FM; Nieva JL; Department of Biochemistry and Molecular Biology (Biomembrane; Laboratory-CSIC), University of the Basque Country, Bilbao, Spain.; Peptides representing a sequence of 23 amino acid residues at the N terminus of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp41 bind and subsequently induce fusion of large unilamellar vesicles (LUV), an activity presumably related to gp41 function in viral infection. These in vitro effects can
Cytotoxic activity of the amino-terminal region of HIV type 1 Nef protein.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1213-20. Unique Identifier : AIDSLINE /MED97454213; Curtain CC; Lowe MG; Arunagiri CK; Mobley PW; Macreadie IG; Azad AA; Biomolecular Research Institute, Parkville Victoria, Australia.; ccurtain@vaxc.cc.monash.edu.au; Myristoylated 21- and 25-residue N-terminal peptides of the Nef protein of HIV-1 lysed human erythrocytes and were cytotoxic toward a human CD4+ T cell line, CEM, and primary human peripheral blood mononuclear cells (PBMCs). The corresponding nonmyristoylated N-terminal peptides were only very weakly hemolytic and cyt
Activation of the HIV type 1 long terminal repeat and viral replication by dimethylsulfoxide and related solvents.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1221-7. Unique Identifier : AIDSLINE /MED97454214; Klebanoff SJ; Mehlin C; Headley CM; Department of Medicine, University of Washington, Seattle 98195-7185,; USA.; The HIV-1 long terminal repeat (LTR) introduced into the macrophage cell line THP-1 and the T lymphocyte cell line Jurkat in association with the luciferase reporter gene is activated by the polar, aprotic solvents dimethylsulfoxide (DMSO), dimethylacetamide (DMAC), and dimethylformamide (DMF). These solvents also gre
Effect of DNA synthesis inhibitors on Kaposi's sarcoma-associated herpesvirus cyclin and major capsid protein gene expression.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1229-33. Unique Identifier : AIDSLINE /MED97454215; Flore O; Gao SJ; Department of Pathology, New York Hospital-Cornell Medical Center, New; York 10021, USA.; Epidemiological studies strongly suggest that a newly discovered herpesvirus, Kaposi s sarcoma associated-herpesvirus (KSHV/HHV8), is the likely infectious cause of Kaposi s sarcoma (KS). Identification of this agent suggests the possibility that existing anti-herpesvirus chemotherapeutics have activity against KSHV.
Interaction of pregnancy steroid hormones and zidovudine in inhibition of HIV type 1 replication in monocytoid and placental Hofbauer cells: implications for the prevention of maternal-fetal transmission of HIV.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1235-42. Unique Identifier : AIDSLINE /MED97454216; Lee AW; Mitra D; Laurence J; Department of Medicine, Cornell University Medical College, New York,; New York 10021, USA.; Zidovudine ( AZT ) has been shown to reduce maternal-fetal transmission of HIV-1 by more than two-thirds in a variety of clinical settings. However, the mechanism of action of AZT in this setting is unclear. Suppression of vertical transmission has occu
Circadian secretory pattern of growth hormone, insulin-like growth factor type I, cortisol, adrenocorticotropic hormone, thyroid-stimulating hormone, and prolactin during HIV infection.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1243-9. Unique Identifier : AIDSLINE /MED97454217; Rondanelli M; Solerte SB; Fioravanti M; Scevola D; Locatelli M; Minoli L; Ferrari E; Department of Internal Medicine, University of Pavia, Italy.; The circadian rhythms of plasma growth hormone (GH), insulin-like growth factor type I (IGF-I), cortisol, adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), and prolactin PRL) were evaluated in 13 HIV-seropositive patients (8 males and 5 females; mean age [+/-SD], 30 +/- 5 years), classified as CDC
HIV type 1 gag subtype A is predominant in Malaysian intravenous drug users.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1251-3. Unique Identifier : AIDSLINE /MED97454218; Kasper P; Chalwatzis N; Duraisamy G; Ofenloch-Hahnle B; Faatz E; Boehringer Mannheim GmbH, Penzberg, Germany.
Sequence analysis of two HTLV type I infections imported to Germany.: AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1255-8. Unique Identifier : AIDSLINE /MED97454219; Ellerbrok H; Fleischer C; Vandamme AM; Kucherer C; Pauli G; Department of Virology, Robert Koch Institute, Berlin, Germany.
Lack of positive outcomes from a cognitive-behavioral HIV and AIDS prevention intervention for inner-city men: lessons from a controlled pilot study.: AIDS Educ Prev. 1997 Aug;9(4):299-313. Unique Identifier : AIDSLINE /MED98017407; Kalichman SC; Rompa D; Coley B; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, USA.; African American men are at increasingly high risk for HIV infection, but there have been few studies of HIV risk reduction interventions for heterosexual ethnic minority men. The present study randomly assigned 81 African American men to one of two HIV prevention interventions: a four-session cognitive-behavioral ski
Unprotected sex and HIV risk taking among young gay men within boyfriend relationships.: AIDS Educ Prev. 1997 Aug;9(4):314-29. Unique Identifier : AIDSLINE /MED98017408; Hays RB; Kegeles SM; Coates TJ; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.; A growing body of research shows that gay men in primary relationships engage in higher rates of unprotected anal intercourse than single gay men. We sought to (a) describe patterns of HIV risk taking among young gay men in boyfriend relationships and (b) identify characteristics of relationships that were most associ
Evaluation of a video-supplement to informed consent: injection drug users and preventive HIV vaccine efficacy trials.: AIDS Educ Prev. 1997 Aug;9(4):330-41. Unique Identifier : AIDSLINE /MED98017409; Fureman I; Meyers K; McLellan AT; Metzger D; Woody G; University of Pennsylvania, PA, USA.; We evaluate the impact of a videotape specially produced to supplement written information about preventive HIV vaccine trials. One hundred eighty-six injection drug users were randomly assigned to an education session in which either: (a) a pamphlet was reviewed before a brief discussion period or (b) the videotape w
Gender differences and other factors associated with HIV testing in a national sample of active drug injectors.: AIDS Educ Prev. 1997 Aug;9(4):342-58. Unique Identifier : AIDSLINE /MED98017410; Davis WR; Deren S; Beardsley M; Wenston J; Tortu S; National Development and Research Institutes, Two World Trade Center,; New York, NY 10048, USA.; Gender, health, HIV risk, and demographic factors were examined with chi-square and logistic regression analyses to assess which of these factors are most predictive of active injection drug users (IDUs ) getting tested for HIV. Analyses were based on 36,898 IDUs recruited to participate in a nationwide multisite HIV
Magic Johnson and children's conceptions of AIDS.: AIDS Educ Prev. 1997 Aug;9(4):359-72. Unique Identifier : AIDSLINE /MED98017411; Quadagno D; Eberstein IW; Foster K; Sittig JE; Sly DF; Kistner JA; Florida State University, Center for the Study of Population,; Tallahassec 32306-4063, USA.; Longitudinal data for a heterogeneous sample of 609 elementary school children are used to assess the long-term effects of Magic Johnson s announcement on children s HIV and AIDS conceptions. Four hypotheses are tested concerning these relationships, and background variables measured prior to Johnson s announcement ar
Perception of risk and sexual self-protective behavior: a methodological critique.: AIDS Educ Prev. 1997 Aug;9(4):373-90. Unique Identifier : AIDSLINE /MED98017412; Poppen PJ; Reisen CA; George Washington University, Washington, DC 20052, USA.; Although several theories suggest that perceptions of the risk of transmission of sexually transmitted diseases, including HIV, motivate individuals to adopt or maintain self-protective behaviors, the research literature has generally failed to demonstrate this relationship. Because many HIV prevention interventions a
HIV and AIDS attitudes in Syleti Bengali community of Chapeltown in Leeds.: AIDS Educ Prev. 1997 Aug;9(4):391-2. Unique Identifier : AIDSLINE /MED98017413; Prasad V; Price H; Pratt A; Pointon B; Leeds School of Medicine, Great Britain.
Legal penalties and HIV [news]: Nurs Stand. 1997 Aug 13;11(47):12. Unique Identifier : AIDSLINE /MED98017158; Waters A
Chronic actinic dermatitis associated with human immunodeficiency virus infection.: Br J Dermatol. 1997 Sep;137(3):431-6. Unique Identifier : AIDSLINE /MED98010057; Meola T; Sanchez M; Lim HW; Buchness MR; Soter NA; Photomedicine Section, Ronald O.Perelman Department of Dermatology,; New York University School of Medicine, NY, USA.; Chronic actinic dermatitis is a photodistributed, eczematous dermatitis that preferentially affects elderly men and persists for months to years. Its occurrence in individuals infected with human immunodeficiency virus (HIV) has been described in five patients. We report four additional cases of this uncommon, chronic
Atypical Lyme borreliosis in an HIV-infected man.: Br J Dermatol. 1997 Sep;137(3):437-9. Unique Identifier : AIDSLINE /MED98010058; Cordoliani F; Vignon-Pennamen MD; Assous MV; Vabres P; Dronne P; Rybojad M; Morel P; Service de Dermatologie, Hopital Saint-Louis, Paris, France.; We report the fourth case of Lyme borreliosis in a man infected with human immunodeficiency virus (HIV). The erythema chronicum migrans was persistent, overlapping with meningoradiculitis. Repeated immunofluorescence tests for Borrelia burgdorferi sensu lato remained negative in both sera and cerebrospinal fluid CSF),
Human herpesvirus 8 DNA sequences in angiosarcoma of the face [letter]: Br J Dermatol. 1997 Sep;137(3):467. Unique Identifier : AIDSLINE /MED98010065; Gyulai R; Kemeny L; Kiss M; Nagy S; Adam E; Nagy F; Dobozy A
Genetic heterogeneity of AIDS-related small non-cleaved cell lymphoma.: Br J Haematol. 1997 Sep;98(3):726-32. Unique Identifier : AIDSLINE /MED97473477; Gaidano G; Pastore C; Gloghini A; Canzonieri V; Capello D; Franceschi S; Saglio G; Carbone A; Department of Medical Sciences, University of Torino at Novara, Italy.; AIDS-related small noncleaved cell lymphoma (AIDS-SNCCL) includes Burkitt s lymphoma (BL) and high-grade B-cell Burkitt-like lymphoma (BLL). Due to the marked polymorphism of AIDS-related non-Hodgkin s lymphomas (AIDS-NHL), the morphologic distinction between these two types of lymphomas is frequently controversial, a
Transplantation of HLA-mismatched CD34+ selected cells in patients with advanced malignancies: severe immunodeficiency and related complications.: Br J Haematol. 1997 Sep;98(3):760-6. Unique Identifier : AIDSLINE /MED97473482; Bacigalupo A; Mordini N; Pitto A; Piaggio G; Podesta M; Benvenuto F; van Lint MT; Valbonesi M; Lercari G; Carlier P; Lamparelli T; Gualandi F; Occhini D; Bregante S; Figari O; Soracco M; Vassallo F; De Stefano G; Divisione Ematologia II, Ospedale San Martino, Genova, Italy.; This trial was designed to test the use of CD34+ selected haemopoietic stem cells (HSC) in HLA-mismatched donor-recipient pairs, following intensive conditioning with thiotepa, antilymphocyte globulin (ALG), cyclophosphamide and single-dose total-body irradiation (sTBI). 10 patients aged 16-50 with advanced malignanci
Detection of maternal cells in human fetal blood during the third trimester of pregnancy using allele-specific PCR amplification.: Br J Haematol. 1997 Sep;98(3):767-71. Unique Identifier : AIDSLINE /MED97473483; Petit T; Dommergues M; Socie G; Dumez Y; Gluckman E; Brison O; Laboratoire de Genetique Oncologique, URA 1967 CNRS, Institut; Gustave-Roussy, Villejuif, France.; Using a highly sensitive allele-specific PCR amplification method, we have previously shown that maternal cells could be detected in all 10 cord bloods tested. This raised the question of whether maternal cells are released into cord blood during the process of delivery or whether they are already present during pregn
Retinoid-mediated inhibition of cell growth with stimulation of apoptosis in aggressive B-cell lymphomas.: Cell Growth Differ. 1997 Oct;8(10):1071-82. Unique Identifier : AIDSLINE /MED98000232; Sundaresan A; Claypool K; Mehta K; Lopez-Berestein G; Cabanillas F; Ford RJ Jr; Department of Molecular Pathology, University of Texas M. D. Anderson; Cancer Center, Houston 77030, USA.; Retinoids have been shown to modulate cell growth and differentiation in a variety of human tumor cell types, but their effects on B-cell non-Hodgkin s lymphomas (NHL-B) have not been explored. In this study, all-trans retinoic acid (ATRA) in the free form and liposome-encapsulated form (L-ATRA) were used to determine
The history of tuberculosis and its resurgence in the community.: West Afr J Med. 1997 Jan-Mar;16(1):1-5. Unique Identifier : AIDSLINE /MED97279362; Ankrah TC; Department of Medicine, School of Medical Sciences, U.S.T. Kumasi.; Tuberculosis is a chronic bacterial infection caused by Mycobacterium tuberculosis and characterised by the formation of granulomas in infected tissues and by florid cell-mediated hypersensitivity. The usual site of disease is the lungs but other organs may be involved.
IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental allergic encephalomyelitis in SJL mice.: Int Immunol. 1997 Sep;9(9):1243-51. Unique Identifier : AIDSLINE /MED97456871; Nagelkerken L; Blauw B; Tielemans M; Division of Immunological and infectious Diseases, TNO Prevention and; Health, Leiden, The Netherlands.; IL-10 and IL-4 were studied with respect to their capacity to inhibit experimental allergic encephalomyelitis (EAE) induced in SJL/J mice by immunization with the proteolipid protein peptide PLP139-151. Treatment with 2 micrograms IL-10/day from day 0 until day 12 delayed onset of disease and inhibited the severity ofJ
Neutralization of HIV-1 primary isolates by polyclonal and monoclonal human antibodies.: Int Immunol. 1997 Sep;9(9):1281-90. Unique Identifier : AIDSLINE /MED97456875; Hioe CE; Xu S; Chigurupati P; Burda S; Williams C; Gorny MK; Zolla-Pazner S; New York University, Veterans Affairs Medical Centers, NY 10010, USA.; To examine antibody-mediated neutralization of HIV-1 primary isolates in vitro, we tested sera and plasma from infected individuals against four clade B primary isolates. These isolates were analyzed further for neutralization by a panel of several human anti-HIV-1 mAb in order to identify the neutralizing epitopes ofJ
A dominant mechanism coordinately suppresses the expression of Th2 lymphokines.: Int Immunol. 1997 Sep;9(9):1347-53. Unique Identifier : AIDSLINE /MED97456882; Weiss A; Waiser J; Serfling E; Nebl G; Samstag Y; Jack HM; Gessner A; Rollinghoff M; Lohoff M; Institute of Clinical Microbiology, University of Erlangen/Nurnberg,; Germany.; This study, we present evidence for a negatively acting control mechanism that coordinately suppresses the synthesis of the Th2 lymphokines IL-4, IL-5 and IL-6. This control mechanism operates in the murine thymoma cell line BW 5147. When cells of this line were fused to four independently established, well-defined ThJ
BCL-XL-regulated apoptosis in T cell development.: Int Immunol. 1997 Sep;9(9):1375-84. Unique Identifier : AIDSLINE /MED97456885; Chao DT; Korsmeyer SJ; Howard Hughes Medical Institute, Department of Medicine and Pathology,; Washington University School of Medicine, St Louis, MO 63110, USA.; Thymocyte differentiation progresses through well-defined stages in which apoptosis is central to the selection of a functional TCR repertoire. In the present study, we explored the developmental effects of BCL-XL, a repressor of apoptosis. We found that endogenous BCL-XL is down-regulated by both positive and negativJ
Detection of glove puncture and skin contamination during caesarean section.: Br J Obstet Gynaecol. 1997 Oct;104(10):1209-11. Unique Identifier : AIDSLINE /MED97472134; Eckford SD; James M; Jackson SR; Hamer AJ; Browning JJ; Department of Obstetrics and Gynaecology, St Michael's Hospital,; Bristol.; Measures that can be taken to reduce exposure to potentially infected body fluids are of particular relevance in obstetric and gynaecological surgery due to high rates of glove puncture and relatively higher prevalence of human immunodeficiency virus seropositivity in the obstetric age group. We describe the use of a J
Effect of RNA secondary structure on the kinetics of DNA synthesis catalyzed by HIV-1 reverse transcriptase.: Biochemistry. 1997 Oct 14;36(41):12459-67. Unique Identifier : AIDSLINE /MED98026067; Suo Z; Johnson KA; Department of Biochemistry and Molecular Biology, 106 Althouse; Laboratory, The Pennsylvania State University, University Park,; Pennsylvania 16802, USA.; The effect of RNA secondary structure on the kinetics of DNA synthesis catalyzed by HIV-1 RT was determined using a 66 nucleotide RNA template containing a stable 12 base pair hairpin structure. Prior to reaching the hairpin structure, the primer elongation by RT was fast and the kinetics of polymerization was not affJ
Effect of RNA secondary structure on RNA cleavage catalyzed by HIV-1 reverse transcriptase.: Biochemistry. 1997 Oct 14;36(41):12468-76. Unique Identifier : AIDSLINE /MED98026068; Suo Z; Johnson KA; Department of Biochemistry and Molecular Biology, 106 Althouse; Laboratory, The Pennsylvania State University, University Park,; Pennsylvania 16802, USA.; Using a synthetic 66 nucleotide RNA template containing a stable hairpin structure derived from the HIV-1 genome, six predominant RNA cleavage products are found during DNA synthesis catalyzed by HIV-1 RT. These major RNA cleavage sites correlate well with the pause sites seen during primer elongation [Suo, Z., & J
Ion selective folding of loop domains in a potent anti-HIV oligonucleotide.: Biochemistry. 1997 Oct 14;36(41):12498-505. Unique Identifier : AIDSLINE /MED98026071; Jing N; Rando RF; Pommier Y; Hogan ME; Department of Molecular Physiology and Biophysics, Baylor College of; Medicine, Houston, Texas 77030, USA.; Previously, we have described inhibition of HIV-1 infection by T30177, 5 -(GTGGTGGGTGGGTGGGT)-3 , an oligonucleotide that is a potent inhibitor of HIV-1 integrase in vitro (Mazumder et al. 1996) Biochemistry 35, 13762). Here a family of oligonucleotides, analogs of T30177, has been studied. On the basis of thermal den
Binding of the nucleocapsid protein of type 1 human immunodeficiency virus to nucleic acids studied using phosphorescence and optically detected magnetic resonance.: Biochemistry. 1997 Oct 14;36(41):12506-18. Unique Identifier : AIDSLINE /MED98026072; Wu JQ; Ozarowski A; Maki AH; Urbaneja MA; Henderson LE; Casas-Finet JR; Department of Chemistry, University of California, Davis, California; 95616, USA.; The binding of p7 nucleocapsid protein of type 1 human immunodeficiency virus (HIV-1) to various oligonucleotides and polynucleotides has been investigated by phosphorescence and optically detected magnetic resonance (ODMR) spectroscopy. The intrinsic spectroscopic probe used in these studies is the photoexcited tripl
Probing the proximity of the core domain of an HIV-1 Tat fragment in a Tat-TAR complex by affinity cleaving.: Biochemistry. 1997 Oct 14;36(41):12592-9. Unique Identifier : AIDSLINE /MED98026082; Huq I; Rana TM; Department of Pharmacology, Robert Wood Johnson (Rutgers) Medical; School, University of Medicine and Dentistry of New Jersey, 675 Hoes; Lane, Piscataway, New Jersey 08854, USA.; Transactivation of human immunodeficiency virus (HIV) gene expression depends upon the interaction of the viral regulatory protein Tat with the transactivation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5 -end of all mRNAs. We have used a site-directed RNA-cleaving strategy to determine
Implications of RNA structure on the annealing of a potent antisense RNA directed against the human immunodeficiency virus type 1.: Biochemistry. 1997 Oct 21;36(42):12711-21. Unique Identifier : AIDSLINE /MED97477317; Eckardt S; Romby P; Sczakiel G; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Im Neuenheimer Feld 242, D-69120 Heidelberg,; Germany.; Antisense RNA-mediated regulation in bacterial systems is related to the kinetics of RNA-RNA annealing in vitro. Here, we investigated the secondary structure of alphaY69, an effective HIV-directed antisense RNA in human cells. Purified RNA preparations contain a single conformer. The global structure was identified b
RNA recognition by a bent alpha-helix regulates transcriptional antitermination in phage lambda.: Biochemistry. 1997 Oct 21;36(42):12722-32. Unique Identifier : AIDSLINE /MED97477318; Su L; Radek JT; Hallenga K; Hermanto P; Chan G; Labeots LA; Weiss MA; Department of Biochemistry & Molecular Biology, University of Chicago,; Chicago, Illinois 60637-5419, USA.; A novel RNA recognition motif is characterized in an arginine-rich peptide. The motif, derived from lambda transcriptional antitermination protein N, regulates an RNA-directed genetic switch. Its characterization by multidimensional nuclear magnetic resonance (NMR) demonstrates specific RNA-dependent folding of N- and
Synergistic inhibition of HIV-1 reverse transcriptase by combinations of chain-terminating nucleotides.: Biochemistry. 1997 Oct 28;36(43):13223-31. Unique Identifier : AIDSLINE /MED98002694; Villahermosa ML; Martinez-Irujo JJ; Cabodevilla F; Santiago E; Department of Biochemistry and Molecular Biology, University of; Navarra, 31080 Pamplona, Spain.; Synergistic inhibition of HIV replication in cell culture has been reported for many combinations of reverse transcriptase inhibitors. However, the biochemical basis underlying this interaction is in most cases unknown. It has been previously shown that combinations of L-697,661 or U-90152s with
Site-specific phosphorylation of the human immunodeficiency virus type-1 Rev protein accelerates formation of an efficient RNA-binding conformation.: Biochemistry. 1997 Oct 28;36(43):13256-62. Unique Identifier : AIDSLINE /MED98002698; Fouts DE; True HL; Cengel KA; Celander DW; Department of Microbiology and College of Medicine, University of; Illinois at Urbana-Champaign, USA.; Phosphorylation is important in the regulation of many cellular processes, yet the precise role of protein phosphorylation for many RNA-binding protein substrates remains obscure. In this report, we demonstrate that phosphorylation of a recombinant human immunodeficiency virus type-1 Rev protein promotes rapid formati
Sexual behavior of HIV-seropositive young men with congenital coagulopathies. Hemophilia Behavioral Intervention Projects HBIEP) Study Group.: J Adolesc Health. 1997 Oct;21(4):232-7. Unique Identifier : AIDSLINE /MED97449438; Remafedi G; Parsons JT; Schultz JR; Schulz SL; Department of Pediatrics, University of Minnesota, Minneapolis, USA.; PURPOSE: To describe the self-reported sexual behaviors of human immunodeficiency virus (HIV)-seropositive youths with congenital coagulopathies in order to guide the development of interventions to prevent secondary transmission. SUBJECTS: A total of 297 HIV-seropositive males, 12-24 years of age, were sampled from 1
Suicidal ideation, bereavement, HIV serostatus and psychosocial variables in partners of men with AIDS.: AIDS Care. 1997 Aug;9(4):373-84. Unique Identifier : AIDSLINE /MED97479230; Rosengard C; Folkman S; Pacific Graduate School of Psychology, Palo Alto, CA 94303, USA.; crosen@itsa.ucsf.edu; This prospective 2-year study examines suicidal ideation in 86 HIV-positive and 167 HIV-negative caregiving partners of men with AIDS. One hundred and fifty-six of the caregivers became bereaved during the course of the study. The study focuses on the relationship between suicidal ideation and bereavement status berea
Suicidality among HIV-positive psychiatric in-patients.: AIDS Care. 1997 Aug;9(4):385-9. Unique Identifier : AIDSLINE /MED97479231; Wood KA; Nairn R; Kraft H; Siegel A; Department of Psychiatry, Emory University School of Medicine,; Atlanta, Georgia, USA.; Rates of suicidality with HIV-infected, seriously mentally ill individuals were investigated. Fifty asymptomatic HIV-positive psychiatric in-patients were compared to a demographically-matched HIV-negative cohort. The groups were similar, except that seropositive subjects were less likely to be diagnosed with schizoph
Perceptions of children and community members concerning the circumstances of orphans in rural Zimbabwe.: AIDS Care. 1997 Aug;9(4):391-405. Unique Identifier : AIDSLINE /MED97479232; Foster G; Makufa C; Drew R; Mashumba S; Kambeu S; Paediatric Department, Mutare Provincial Hospital, Zimbabwe.; Focus group discussions and interviews were held with 40 orphans, 25 caretakers and 33 other community workers from a rural area near Mutare, Zimbabwe . Orphan concerns included feeling different from other children, stress, stigmatization, exploitation, schooling, lack of visits
Sexual relationships, condom use and risk perception among female bar workers in north-west Tanzania.: AIDS Care. 1997 Aug;9(4):407-16. Unique Identifier : AIDSLINE /MED97479233; Mgalla Z; Pool R; Royal Tropical Institute, Amsterdam, The Netherlands.; This paper discusses the background characteristics, sexual relationships, condom use and risk perception of bar workers in Magu district, north-west Tanzania . Bar workers in Magu are geographically mobile. They are not highly educated but probably have a higher level of schoolin
STD/HIV/AIDS knowledge, beliefs and practices of traditional healers in Botswana.: AIDS Care. 1997 Aug;9(4):417-25. Unique Identifier : AIDSLINE /MED97479234; Chipfakacha VG; Department of Health & Social Welfare, Mmabatho, Republic of South; Africa.; The study investigated knowledge, beliefs, practices and experiences of traditional healers in relation to sexually transmitted diseases (STDs), HIV and AIDS. Traditional healers see about 70% of the African patients, with all kinds of ailments. The advent of HIV/AIDS and the introduction of home-based care in most Af
Widely varying HIV prevalence and risk behaviours among the ethnic minority peoples of northern Thailand.: AIDS Care. 1997 Aug;9(4):427-39. Unique Identifier : AIDSLINE /MED97479235; Beyrer C; Celentano DD; Suprasert S; Sittitrai W; Nelson KE; Kongsub B; Go V; Phanupak P; Johns Hopkins University School of Hygiene and Public Health, USA.; rihes@cmu.chiangmai.ac.th; We compared HIV prevalence, risk behaviours, and social and sexual norms among nine ethnic minority (Hilltribe) groups in northern Thailand . Communities were selected on the basis of size, ethnicity, development level and geography. Subjects (15-45 years) were stratified by gende
HIV-seropositive men who engage in high-risk sexual behaviour: psychological characteristics and implications for prevention.: AIDS Care. 1997 Aug;9(4):441-50. Unique Identifier : AIDSLINE /MED97479236; Kalichman SC; Greenberg J; Abel GG; Psychology Department, Georgia State University, Atlanta 30303, USA.; psysck@panther.gsu.edu; A minority of people who test HIV seropositive continue to engage in sexual behaviour that places their partners at high risk for HIV infection. However, little is known about factors that contribute to sexual risk behaviour among. HIV-seropositive men. In this study, HIV-seropositive men participating in substance ab
A new out-patient care facility for HIV-infected destitute populations in Paris, France.: AIDS Care. 1997 Aug;9(4):451-9. Unique Identifier : AIDSLINE /MED97479237; Chauvin P; Mortier E; Carrat F; Imbert JC; Valleron AJ; Lebas J; Department of Biostatistics and Medical Informatics (INSERM U444),; Paris, France.; In France , the entire population theoretically has access to health coverage, but in fact a section of the poorest population does not. Institutions have therefore been set up to provide medical care for the destitute. The objectives of this study were to describe the social charac
Cross-sectional survey of hospital paediatric HIV/AIDS care in Catalonia, 1992. Hospital Contributors.: AIDS Care. 1997 Aug;9(4):461-9. Unique Identifier : AIDSLINE /MED97479238; Miret M; Vall M; Fortuny C; Casabona J; Centre d'Estudis Epidemiologics sobre la Sida a Catalunya CEESCAT),; Badalona, Spain.; A cross-sectional survey to assess the impact of the paediatric HIV/AIDS epidemic on the hospital-based health care system was performed in state-financed hospitals in Catalonia during 1992, raising issues of relevance today. Out of the 27 hospitals contacted, 20 responded. A considerable proportion of the health care
Sexual Risk Cognitions Questionnaire: a reliability and validity study.: AIDS Care. 1997 Aug;9(4):471-80. Unique Identifier : AIDSLINE /MED97479239; Shah D; Thornton S; Burgess AP; Psychological Medicine Unit, Mental Health Centre, Chelsea &; Westminster Hospital, London, UK.; The Sexual Risk Cognitions Questionnaire was designed to assess the type and frequency of cognitions associated with unsafe sex. It consists of 22 core items (SRCQ-22) with six subsections. Each subsection consists of 8-12 items designed for specific subgroups defined by gender, sexual orientation and HIV serostatus.
Encounters with the Israeli Health Service: impressions from a support group for people with HIV.: AIDS Care. 1997 Aug;9(4):481-6. Unique Identifier : AIDSLINE /MED97479240; Weishut DJ; Israel AIDS Task Force, Tel Aviv, Israel.; The article which follows documents one of the first short-term support groups for HIV-infected people (PWH) in Israel . The group enabled its members to cope in a positive way with issues of life and death and with the daily hardships that accompany their condition, and became an e
Cancer in AIDS.: Curr Opin Oncol. 1997 Sep;9(5):B135-8. Unique Identifier : AIDSLINE /MED97468087
Treatment of epidemic (AIDS-related) Kaposi's sarcoma.: Curr Opin Oncol. 1997 Sep;9(5):433-9. Unique Identifier : AIDSLINE /MED97468077; Jie C; Tulpule A; Zheng T; Masood R; Espina B; Gill PS; Department of Medicine and Pathology, University of Southern; California, School of Medicine, Los Angeles, USA.; Kaposi s sarcoma (KS) is the most common tumor seen in patients with HIV-1 infection. KS causes significant morbidity and mortality through involvement of the skin and visceral organs. The optimal treatment for KS depends on the extent of the disease and immunologic status. However, with knowledge gained on the pathog
Human herpesvirus-8.: Curr Opin Oncol. 1997 Sep;9(5):440-9. Unique Identifier : AIDSLINE /MED97468078; Gillison ML; Ambinder RF; Johns Hopkins Oncology Center, Baltimore, MD 21231, USA.; Our current understanding of Kaposi s sarcoma (KS) has evolved from initial descriptions of this idiopathic sarcoma to a progressively detailed characterization of its probable infectious origin. This article traces the explosive discovery of human herpesvirus-8 (HHV-8) and its etiologic associations with KS, Castle
HIV-associated lymphomas.: Curr Opin Oncol. 1997 Sep;9(5):450-4. Unique Identifier : AIDSLINE /MED97468079; Straus DJ; Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.; Intermediate and high-grade non-Hodgkin s lymphomas (NHL) with a B-cell phenotype are AIDS-defining illnesses. The incidence of systemic NHL increased greatly and primary central nervous system NHL increased even more in the HIV-infected population. Further increases in frequency are anticipated as HIV-infected indivi
The use of new antiretroviral therapy in combination with chemotherapy.: Curr Opin Oncol. 1997 Sep;9(5):455-64. Unique Identifier : AIDSLINE /MED97468080; Tan B; Ratner L; Washington University Medical Center, St. Louis, MO 63110, USA.; With rapid scientific advances in HIV pathogenesis and antiretroviral therapy, the oncologist is faced with new challenges in the treatment of patients with HIV infection and malignancy. HIV infection, by causing immune dysregulation and cytokine production, may alter the natural history of certain neoplasms. Treatmen
[Esophageal ulcer in a patient with AIDS]: Enferm Infecc Microbiol Clin. 1997 May;15(5):269-70. Unique Identifier : AIDSLINE /MED97398768; Blanco JR; Ibarra V; Oteo JA; Servicio de Medicina Interna y Enfermedades Infecciosas, Hospital de; La Rioja.
[Pneumonia caused by Rhodococcus equi in patients with AIDS: difficulty in defining the most appropriate initial treatment letter)]: Enferm Infecc Microbiol Clin. 1997 May;15(5):274-5. Unique Identifier : AIDSLINE /MED97398772; Baraia-Etxaburu J; Malero P; Unzaga MJ; Teira R; Munoz J; Cisterna R; Santamaria JM
[Ritonavir]: Enferm Infecc Microbiol Clin. 1997 May;15(5):281. Unique Identifier : AIDSLINE /MED97398778
GaLV pseudotyped vectors and cationic lipids transduce human CD34+ cells.: Hum Gene Ther. 1997 Sep 20;8(14):1685-94. Unique Identifier : AIDSLINE /MED97462644; Dybing J; Lynch CM; Hara P; Jurus L; Kiem HP; Anklesaria P; Targeted Genetics Corporation, Seattle, WA 98101, USA.; High transduction frequency of hematopoietic stem/progenitor cells is essential to derive clinical benefits for treating certain inherited and acquired diseases. We demonstrate here stable gene transfer into human bone marrow-derived CD34+ progenitors using cationic lipids to facilitate GaLV and amphotroic pseudotyped
Female genital mutilation [editorial]: Int J STD AIDS. 1997 Oct;8(10):599-601. Unique Identifier : AIDSLINE /MED97454142; Fox EF; de Ruiter A; Bingham JS
Sex, thrush and bacterial vaginosis.: Int J STD AIDS. 1997 Oct;8(10):603-8. Unique Identifier : AIDSLINE /MED97454143; Hay PE; Ugwumadu A; Chowns J; Department of Genitourinary Medicine, St George's Hospital, London,; UK.; Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of childbearing age. In some women it shows a relapsing and remitting course with apparently spontaneous onset and resolution. There are intermediate patterns of vaginal flora in which lactobacilli and other species co-exist. We asked wome
Physician concurrence with primary care guidelines for persons with HIV disease.: Int J STD AIDS. 1997 Oct;8(10):609-13. Unique Identifier : AIDSLINE /MED97454144; Heath K; Hogg RS; Singer J; Schechter MT; O'Shaughnessy MV; Montaner JS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; An anonymous questionnaire was mailed to 3 groups of physicians in British Columbia: 659 registrants of a province-wide human immunodeficiency virus (HIV) drug treatment programme (Group 1); 765 who had had a patient test positive for HIV (Group 2); and a random sample of 484 (Group 3). Questionnaires provided data ab
Recombinant human interferon-beta for condylomata acuminata: a randomized, double-blind, placebo-controlled study of intralesional therapy.: Int J STD AIDS. 1997 Oct;8(10):614-21. Unique Identifier : AIDSLINE /MED97454145; Bornstein J; Pascal B; Zarfati D; Goldshmid N; Abramovici H; Department of Obstetrics and Gynecology, Carmel Medical Center and; Rappaport Faculty of Medicine, Technion-Israel Institute of; Technology, Haifa, Israel.; To assess the efficacy of a novel glycosylated mammalian cell derived recombinant human interferon-beta (r-hIFN-beta-1a) in the intralesional treatment of genital condylomata acuminata. The study was randomized, double-blind and placebo-controlled. Patients (n=60) with up to 8 distinct condylomata acuminata were rando
Recombinant human interferon-beta in the treatment of condylomata acuminata.: Int J STD AIDS. 1997 Oct;8(10):622-8. Unique Identifier : AIDSLINE /MED97454146; Dinsmore W; Jordan J; O'Mahony C; Harris JR; McMillan A; Radcliffe KW; Engrand P; Jackson BW; Galazka AR; Abdul-Ahad AK; Illingworth JM; Department of Genito-Urinary Medicine, Royal Victoria Hospital,; Belfast, Northern Ireland.; The number of clinic consultations for condylomata acuminata genital warts) has increased substantially during the last 30 years. Most infections produce benign lesions but a few types may be associated with cervical and penile cancers. Interferons (IFN) have shown antiviral properties to these infections and IFN-beta
Introduction of HIV into drug injector networks outside AIDS epicentres.: Int J STD AIDS. 1997 Oct;8(10):629-35. Unique Identifier : AIDSLINE /MED97454147; Williams ML; Zhao Z; Bowen AM; Freeman RC; Elwood WN; Rusek R; NOVA Research Company, Bethesda, Maryland, USA.; Injection drug users (IDUs) continue to be at risk for HIV infection despite high levels of knowledge about how human immunodeficiency virus/acquired immunodeficiency syndrome HIV/AIDS) is transmitted. Yet, among not-in-treatment injection drug users, the chances of becoming infected with HIV vary substantially. Infor
Sexually transmitted diseases and human immunodeficiency virus infections in women attending an antenatal clinic in Abidjan, Cote d'Ivoire.: Int J STD AIDS. 1997 Oct;8(10):636-8. Unique Identifier : AIDSLINE /MED97454148; Diallo MO; Ettiegne-Traore V; Maran M; Kouadio J; Brattegaard K; Makke A; Van Dyck E; Laga M; De Cock KM; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; A cross-sectional survey was conducted among women attending an antenatal clinic in Abidjan to determine the prevalence of sexually transmitted diseases (STDs) and HIV infection, and to identify factors associated with the presence of gonococcal and/or chlamydial cervical infection. Among 546 women, 3.7% had a gonococ
Relationship of genital wart burden to therapeutic response to fluorouracil/epinephrine injectable gel.: Int J STD AIDS. 1997 Oct;8(10):639-42. Unique Identifier : AIDSLINE /MED97454149; Swinehart JM; Korey A; Orenberg EK; Colorado Medical Research Center, Denver 80210, USA.; The efficacy of a single cycle of a new therapy for genital warts, intradermal fluorouracil/epinephrine (5-FU/epi) injectable gel, has been evaluated in 2 large pivotal trials; the objective of this study was to evaluate a second cycle of treatment. Twenty-two patients with total wart areas of 5-447 mm2 were treated w
The last sexual encounter: the contextualization of sexual risk behaviour.: Int J STD AIDS. 1997 Oct;8(10):643-5. Unique Identifier : AIDSLINE /MED97454150; Leonard L; Ross MW; Center for Health Promotion Research and Development, University of; Texas-Houston School of Public Health, 77225, USA.; We aim to apply critical incident methodology to details of respondents last sexual encounter to provide contextualized data on sexual behaviour and alleviate the problem of recall bias. In areas of Houston, Texas, registering high prevalence rates of syphilis, we elicited information from 400 men and women about the
HIV infection among pregnant women in Burkina Faso: a nationwide serosurvey.: Int J STD AIDS. 1997 Oct;8(10):646-51. Unique Identifier : AIDSLINE /MED97454151; Sangare L; Meda N; Lankoande S; Van Dyck E; Cartoux M; Compaore IP; Catraye J; Sanou PT; Soudre R; Department of Microbiology, Faculty of Health Sciences, University of; Ouagadougou, Burkina Faso, West Africa.; To determine the prevalence of HIV infection among pregnant women in Burkina Faso and to identify factors associated with HIV infection in this population, we performed in 4 antenatal clinics in 4 urban centres located in the centre, the north, the east and the south-west of the c
Calcifying Pneumocystis carinii thyroiditis.: Int J STD AIDS. 1997 Oct;8(10):652-4. Unique Identifier : AIDSLINE /MED97454152; O'Donovan ML; Fitzpatrick F; Mulcahy F; Gaffney EF; Department of Histopathology, St James's Hospital, Dublin, Ireland.
Extragenital chancre of the tongue.: Int J STD AIDS. 1997 Oct;8(10):655-6. Unique Identifier : AIDSLINE /MED97454153; Arunkumar S; Prasad S; Loganathan B; Johnson M; Jayapaul K; Institute of Venereology, Government General Hospital, Chennai Medical; College, Tamilnadu, India.
An audit of clinic acceptability for patients.: Int J STD AIDS. 1997 Oct;8(10):657-8. Unique Identifier : AIDSLINE /MED97454154; Fisk PG; Julian S; Department of Genito-Urinary Medicine, Leicester Royal Infirmary, UK.
Female genital mutilation in a genitourinary medicine clinic: a case note review [letter]: Int J STD AIDS. 1997 Oct;8(10):659-60. Unique Identifier : AIDSLINE /MED97454155; Fox E; de Ruiter A; Bingham JS
Testosterone treatment of clinical hypogonadism in patients with HIV/AIDS.: Int J STD AIDS. 1997 Sep;8(9):537-45. Unique Identifier : AIDSLINE /MED97437808; Rabkin JG; Rabkin R; Wagner GJ; Department of Psychiatry, College of Physicians and Surgeons, Columbia; University, New York, USA.; The use of testosterone to treat clinical symptoms of hypogonadism and wasting among patients with HIV/AIDS is a relatively new area of inquiry and clinical application. Outcome measures have included changes in mood, libido, energy, weight and muscle mass. The purpose of this review is to identify the questions most
Ureaplasma urealyticum [editorial]: Int J STD AIDS. 1997 Sep;8(9):546-51. Unique Identifier : AIDSLINE /MED97437809; Hudson MM; Talbot MD
Prognostic markers and surrogate markers of clinical progression in HIV infection.: Int J STD AIDS. 1997 Sep;8(9):552-6; quiz 557. Unique Identifier : AIDSLINE /MED97437810; Churchill DR; Department of Genitourinary Medicine and Communicable Diseases,; Imperial College School of Medicine at St Mary's, London, UK.
Isolated microscopic haematuria in the genitourinary clinic: the value of renal biopsy.: Int J STD AIDS. 1997 Sep;8(9):558-62. Unique Identifier : AIDSLINE /MED97437811; Topham P; Young S; Harper S; Furness P; Riley V; Feehally J; Department of Nephrology, Leicester General Hospital, UK.; Isolated microscopic haematuria is a common finding in the genitourinary clinic. The conventional approach to investigation includes urological referral for cystourethroscopy if renal imaging is normal. However the diagnostic yield is very low; in particular urothelial malignancy at age
Bacterial infections in adult patients hospitalized with AIDS: case-control study of prophylactic efficacy of trimethoprim-sulfamethoxazole versus aerosolized pentamidine.: Int J STD AIDS. 1997 Sep;8(9):563-9. Unique Identifier : AIDSLINE /MED97437812; Tabet SR; Krone MR; Hooton TM; Koutsky LA; Holmes KK; Department of Medicine, School of Medicine, University of Washington,; Seattle, USA.; To determine the association between trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis for Pneumocystis carinii pneumonia and risk of bacterial infections in persons with AIDS, we abstracted hospital records from 6496 adult admissions to 42 hospitals in western Washington state. Of these admissions, 570 involved 637
HIV/AIDS care giving physicians: their experience and practice patterns.: Int J STD AIDS. 1997 Sep;8(9):570-5. Unique Identifier : AIDSLINE /MED97437813; Heath KV; Bally G; Yip B; O'Shaughnessy MV; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; To identify associations between HIV-related experience and patterns of service provision, physicians across Canada were solicited by mail to register in a national network of HIV/AIDS care givers. Respondents provided data about: personal, demographic and practice characteristics;
Patterns of sexually transmitted diseases in female sex workers in Surabaya, Indonesia.: Int J STD AIDS. 1997 Sep;8(9):576-80. Unique Identifier : AIDSLINE /MED97437814; Joesoef MR; Linnan M; Barakbah Y; Idajadi A; Kambodji A; Schulz K; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; Sex workers and their clients as core groups of high frequency transmitters play a dominant role in the transmission of HIV and other sexually transmitted diseases (STDs). In Surabaya, Indonesia , little is known about the prevalence of STDs in various sex establishments. We cond
Intracavitary contact X-ray therapy of oral HIV-associated Kaposi's sarcoma.: Int J STD AIDS. 1997 Sep;8(9):581-4. Unique Identifier : AIDSLINE /MED97437815; Caccialanza M; Piccinno R; Gnecchi L; Beretta M; Cusini M; Department of Photoradiotherapy, University of Milan, Ospedale; Maggiore, IRCCS, Italy.; A retrospective study was performed to assess the efficacy and low mucosal toxicity of intracavitary contact X-ray therapy ICRT), a proposed treatment of small/medium sized lesions of oral HIV-associated Kaposi s sarcoma (HIV-KS). Twenty-six patients with histologically confirmed oral HIV-KS underwent ICRT in the peri
Immunohistochemical investigations of genital ulcers caused by Haemophilus ducreyi.: Int J STD AIDS. 1997 Sep;8(9):585-8. Unique Identifier : AIDSLINE /MED97437816; Abeck D; Freinkel AL; Korting HC; Szeimis RM; Ballard RC; Department of Dermatology and Allergy, Technical University, Munich,; Germany.; To gain information on the specific composition of the inflammatory infiltrate of genital ulcers caused by Haemophilus ducreyi, biopsies of 6 genital ulcers which were diagnosed as chancroid on clinical and microbiological grounds were subjected to immunohistochemical investigations after conventional haematoxylineosi
Colpitis macularis and macular vaginitis unrelated to Trichomonas vaginalis infection.: Int J STD AIDS. 1997 Sep;8(9):589-91. Unique Identifier : AIDSLINE /MED97437817; Sonnex C; Department of Genitourinary Medicine, Addenbrooke's Hospital,; Cambridge, UK.
Outpatient therapy of HIV-associated oral and oesophageal candidosis.: Int J STD AIDS. 1997 Sep;8(9):592-4. Unique Identifier : AIDSLINE /MED97437818; Ustianowski AP; Leake H; Evans S; Brighton Health Care, East Sussex, UK.
Correlation between total and CD4 lymphocyte counts in HIV infection [letter]: Int J STD AIDS. 1997 Sep;8(9):597. Unique Identifier : AIDSLINE /MED97437819; Brettle RP
Review of drug expenditure for a genitourinary medicine department [letter]: Int J STD AIDS. 1997 Sep;8(9):597-8. Unique Identifier : AIDSLINE /MED97437820; Talbot P; Moss TR
Detection of bovine immunodeficiency virus antibodies in cattle by western blot assay with recombinant gag protein.: J Vet Diagn Invest. 1997 Oct;9(4):347-51. Unique Identifier : AIDSLINE /MED98018041; Zhang S; Xue W; Wood C; Chen Q; Kapil S; Minocha HC; Department of Diagnostic Medicine/Pathobiology, College of Veterinary; Medicine, Kansas State University, Manhattan 66506, USA.; A western blot assay using purified recombinant bovine immunodeficiency virus gag protein has been developed for detection of bovine immunodeficiency virus antibodies in bovine serum samples. The test was standardized with known bovine immunodeficiency virus positive and negative bovine serum samples and the monoclona
Red cell aplasia caused by parvovirus B19 in AIDS: use of i.v. immunoglobulin.: Ann Hematol. 1997 Jul-Aug;75(1-2):67-8. Unique Identifier : AIDSLINE /MED97463986; Koduri PR; Kumapley R; Khokha ND; Patel AR; Department of Medicine, Cook County Hospital, Chicago, IL 60612, USA.; We describe the case of a 34-year-old man with AIDS who developed severe anemia due to chronic pure red cell aplasia (PRCA) caused by parvovirus B19. Following initial treatment with an infusion of intravenous immunoglobulin (IVIg), 1 g/kg, PRCA resolved, but there was a recurrence of severe anemia in 3 months. Retrea
Investigating the relationship between economic status and HIV risk.: J Health Care Poor Underserved. 1997 Nov;8(4):416-23. Unique Identifier : AIDSLINE /MED97474913; Murrain M; Barker T; School of Natural Science, Hampshire College, Amherst, MA 01002, USA.; Although anecdotal information suggests that there is a relationship between socioeconomic status and HIV risk, there have been few investigations of that possible relationship. Understanding that relationship can have important implications for designing and implementing prevention programs. This study investigated t
Strategies for suppression, containment, and eradication of resurgent tuberculosis.: J Health Care Poor Underserved. 1997 Nov;8(4):424-36. Unique Identifier : AIDSLINE /MED97474914; Young RC Jr; Rachal RE; Bailey SB; Tate HL; Nelson-Knuckles B; Department of Family and Preventive Medicine, Meharry Medical College,; Nashville, TN 37208, USA.; This review provides strategies for the suppression, containment, and eventual eradication of resurgent tuberculosis. Some ethnic minority communities are at greatest risk because of the prevalence of human immunodeficiency virus/acquired immunodeficiency syndrome, poverty and malnutrition, congregate living situation
An analysis of unmet need for HIV services: The Houston Study.: J Health Care Poor Underserved. 1997 Nov;8(4):446-60. Unique Identifier : AIDSLINE /MED97474916; Montoya ID; Richard AJ; Bell DC; Atkinson JS; HIV/AIDS is indicative of general institutional neglect that disproportionately affects minorities, poor, and underserved populations. Among women and minorities, HIV infection is associated with preexisting economic distress. Moreover, socioeconomic resources, gender, and race/ethnicity may determine access to medica
Prevalence of human immunodeficiency virus infection, mortality rate, and serogroup distribution among patients with pneumococcal bacteremia at Denver General Hospital, 1984-1994.: Clin Infect Dis. 1997 Aug;25(2):195-9. Unique Identifier : AIDSLINE /MED97473667; Hibbs JR; Douglas JM Jr; Judson FN; McGill WL; Rietmeijer CA; Janoff EN; Infectious Disease Section, Veterans Affairs Medical Center,; Minneapolis, Minnesota 55417, USA.; Pandemics of human immunodeficiency virus (HIV) type 1 infection and penicillin resistance highlight the urgency of preventing invasive pneumococcal disease with vaccination. We characterized pneumococcal serogroup distribution and the mortality rate among 460 patients with pneumococcal bacteremia from 1984 through 19
Mycobacterium xenopi infection in patients with human immunodeficiency virus infection.: Clin Infect Dis. 1997 Aug;25(2):206-10. Unique Identifier : AIDSLINE /MED97473669; el-Helou P; Rachlis A; Fong I; Walmsley S; Phillips A; Salit I; Simor AE; Department of Medicine, Sunnybrook Health Science Centre, Toronto,; Ontario, Canada.; Mycobacterium xenopi is one of the most frequently isolated nontuberculous mycobacteria in Ontario, Canada . We reviewed the records of 28 human immunodeficiency virus (HIV)-infected patients from whom M. xenopi was isolated between 1982 and 1995. M. xenopi was recovered from respir
Pneumocystis carinii pneumonia in patients without human immunodeficiency virus infection [editorial; comment]: Clin Infect Dis. 1997 Aug;25(2):219-20. Unique Identifier : AIDSLINE /MED97473672; Walzer PD
Variation of chest radiographic patterns in pulmonary tuberculosis by degree of human immunodeficiency virus-related immunosuppression. The Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). The AIDS Clinical Trials Group ACTG).: Clin Infect Dis. 1997 Aug;25(2):242-6. Unique Identifier : AIDSLINE /MED97473677; Perlman DC; el-Sadr WM; Nelson ET; Matts JP; Telzak EE; Salomon N; Chirgwin K; Hafner R; Division of Infectious Diseases, Beth Israel Medical Center, New York,; New York 10003, USA.; Our aim was to evaluate the effect of human immunodeficiency virus (HIV) disease stage on chest radiographic (CXR) findings among patients with HIV-related pulmonary tuberculosis (TB). Data are from a prospective multicenter treatment trial for HIV-related TB. Baseline CXR findings and CD4+ lymphocyte counts were comp
Parasitic sinusitis and otitis in patients infected with human immunodeficiency virus: report of five cases and review.: Clin Infect Dis. 1997 Aug;25(2):267-72. Unique Identifier : AIDSLINE /MED97473680; Dunand VA; Hammer SM; Rossi R; Poulin M; Albrecht MA; Doweiko JP; DeGirolami PC; Coakley E; Piessens E; Wanke CA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston,; Massachusetts 02215, USA.; We describe five cases of parasitic sinusitis and otitis in patients infected with human immunodeficiency virus (HIV) and review 14 reported cases. The pathogens identified in our group of patients included agents such as Microsporidium, Cryptosporidium, and Acanthamoeba species. The clinical features common to these
Histoplasmosis and kidney disease in patients with AIDS.: Clin Infect Dis. 1997 Aug;25(2):281-4. Unique Identifier : AIDSLINE /MED97473682; Burke DG; Emancipator SN; Smith MC; Salata RA; Department of Medicine, Case Western Reserve University, University; Hospitals of Cleveland, Ohio 44106-5083, USA.; Renal disease in patients infected with human immunodeficiency virus (HIV) often presents with significant proteinuria and progressive renal failure; focal glomerulosclerosis is the most common renal pathology identified. To our knowledge, we report the first case of nephrotic-range proteinuria and preserved renal fun
To tap or not to tap? [editorial; comment]: Clin Infect Dis. 1997 Aug;25(2):289-91. Unique Identifier : AIDSLINE /MED97473684; Tauber MG
Genital ulceration and clinical acumen [editorial; comment]: Clin Infect Dis. 1997 Aug;25(2):299-300. Unique Identifier : AIDSLINE /MED97473686; Ronald A
Incidence and epidemiology of nosocomial infections in patients infected with human immunodeficiency virus [see comments]: Clin Infect Dis. 1997 Aug;25(2):318-20. Unique Identifier : AIDSLINE /MED97473690; Frank U; Daschner FD; Schulgen G; Mills J; San Francisco General Hospital, University of California, USA.; In a prospective study, we investigated the incidence, characteristics, and risk factors of nosocomial infections (NIs) in patients with human immunodeficiency virus disease. There was a total of 528 admissions of 405 eligible patients; 46 NIs (8.7% per discharge) were identified in 39 patients. The proportional frequ
Changing epidemiology of nosocomial infections in human immunodeficiency virus-infected patients [editorial; comment]: Clin Infect Dis. 1997 Aug;25(2):321-3. Unique Identifier : AIDSLINE /MED97473691; Kuehnert MJ; Jarvis WR
Increased endothelin levels in cerebrospinal fluid samples from adults with bacterial meningitis.: Clin Infect Dis. 1997 Aug;25(2):329-30. Unique Identifier : AIDSLINE /MED97473696; Koedel U; Gorriz C; Lorenzl S; Pfister HW; Department of Neurology, Ludwig-Maximilians-University of Munich,; Klinikum Grosshadern, Germany.
Measurement of human immunodeficiency virus (HIV) type 1 RNA load distinguishes progressive infection from nonprogressive HIV-1 infection in men and women.: Clin Infect Dis. 1997 Aug;25(2):332-3. Unique Identifier : AIDSLINE /MED97473698; Fang G; Siegal FP; Weiser B; Grimson R; Anastos K; Back S; Burger H; Wadsworth Center, New York State Department of Health, Albany, USA.
Spontaneous rupture of the spleen revealing primary human immunodeficiency virus infection.: Clin Infect Dis. 1997 Aug;25(2):336-7. Unique Identifier : AIDSLINE /MED97473701; Barrier JH; Bani-Sadr F; Gaillard F; Raffi F; Department of Internal Medicine, Hotel-Dieu, Nantes, France.
Recurrent iritis after intravenous administration of cidofovir.: Clin Infect Dis. 1997 Aug;25(2):337-8. Unique Identifier : AIDSLINE /MED97473702; Palau LA; Tufty GT; Pankey GA; Department of Infectious Diseases, Ochsner Clinic, New Orleans,; Louisiana, USA.
Disseminated histoplasmosis and human immunodeficiency virus type 1 infection: risk factors in Guatemala [letter]: Clin Infect Dis. 1997 Aug;25(2):343-4. Unique Identifier : AIDSLINE /MED97473705; Segura L; Rojas M; Pelaez N; Shor-Posner G; RosaRe D; Moreno J; Klaskala W; Baum MK
Enterocytozoon bieneusi infection in patients who are not infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1997 Aug;25(2):344. Unique Identifier : AIDSLINE /MED97473706; Albrecht H; Sobottka I
Effect of food intake on the bioavailability of itraconazole [letter]: Clin Infect Dis. 1997 Aug;25(2):344-5. Unique Identifier : AIDSLINE /MED97473707; Feola D; Rapp RP
Antibody response to Haemophilus influenzae type b vaccine in relation to the number of CD4+ T lymphocytes in adults infected with human immunodeficiency virus.: Clin Infect Dis. 1997 Sep;25(3):600-6. Unique Identifier : AIDSLINE /MED97458116; Kroon FP; van Dissel JT; Rijkers GT; Labadie J; van Furth R; Department of Infectious Diseases, University Hospital Leiden, the; Netherlands.; A prospective study of antibody production by adults infected with human immunodeficiency virus (HIV) after vaccination with tetanus toxoid-conjugated Haemophilus influenzae type b (Hib) vaccine was conducted. Concentrations of antibodies to the two immunogenic components of the vaccine (i.e., polyribosylribitolphosph
Clinical correlates of interferon gamma production in patients with tuberculosis.: Clin Infect Dis. 1997 Sep;25(3):617-20. Unique Identifier : AIDSLINE /MED97458120; Sodhi A; Gong J; Silva C; Qian D; Barnes PF; Department of Medicine, University of Southern California School of; Medicine, Los Angeles 90033, USA.; To determine if the capacity to produce interferon (IFN) gamma is related to the clinical manifestations of tuberculosis, we correlated Mycobacterium tuberculosis-induced IFN-gamma production by peripheral blood mononuclear cells (PBMCs) with clinical, radiographic, and laboratory variables for 63 human immunodeficien
Comparison of combination therapy regimens for treatment of human immunodeficiency virus-infected patients with disseminated bacteremia due to Mycobacterium avium. ANRS Trial 033 Curavium Group. Agence Nationale de Recherche sur le Sida.: Clin Infect Dis. 1997 Sep;25(3):621-9. Unique Identifier : AIDSLINE /MED97458121; May T; Brel F; Beuscart C; Vincent V; Perronne C; Doco-Lecompte T; Saint-Marc T; Dautzenberg B; Grosset J; Service de Maladies Infectieuses et Tropicales, Hopitaux de Brabois,; Nancy, France.; We conducted a randomized, open-label trial in 42 French hospitals to compare the clinical and bacteriologic efficacy of combination therapy with clarithromycin/clofazimine (Clm/Clof) with that of combination therapy with clarithromycin/rifabutin/ethambutol (Clm/Rib/Et
Varicella-zoster virus (VZV) DNA in cerebrospinal fluid of patients infected with human immunodeficiency virus: VZV disease of the central nervous system or subclinical reactivation of VZV infection?: Clin Infect Dis. 1997 Sep;25(3):634-9. Unique Identifier : AIDSLINE /MED97458123; Cinque P; Bossolasco S; Vago L; Fornara C; Lipari S; Racca S; Lazzarin A; Linde A; Department of Infectious Diseases, San Raffaele Scientific Institute,; Luigi Sacco Hospital, Milan, Italy.; To identify varicella-zoster virus (VZV) infections of the nervous system in patients infected with human immunodeficiency virus (HIV), polymerase chain reaction (PCR) analysis of cerebrospinal fluid (CSF) samples from 514 consecutive HIV-infected patients with neurological disease was performed to detect VZV DNA. VZV
Comparison of sensitivities to two commercially available tuberculin skin test reagents in persons with recent tuberculosis [see comments]: Clin Infect Dis. 1997 Sep;25(3):661-3. Unique Identifier : AIDSLINE /MED97458127; Duchin JS; Jereb JA; Nolan CM; Smith P; Onorato IM; Department of Medicine, University of Washington, Seattle 98104, USA.; Discrepancies have been reported between results obtained with tuberculin skin tests (TSTs) performed with use of different reagents. We compared TST results and determined the sensitivities of the two commercially available TSTs in 51 human immunodeficiency virus-negative persons with culture-confirmed active tubercu
Factors influencing time to sputum conversion among patients with smear-positive pulmonary tuberculosis [see comments]: Clin Infect Dis. 1997 Sep;25(3):666-70. Unique Identifier : AIDSLINE /MED97458129; Telzak EE; Fazal BA; Pollard CL; Turett GS; Justman JE; Blum S; Bronx Lebanon Hospital Center and the Department of Medicine, Albert; Einstein College of Medicine, New York 10457, USA.; For hospitalized patients with smear-positive pulmonary or laryngeal tuberculosis, the Centers for Disease Control and Prevention recommends that three consecutive sputum samples be negative for acid-fast bacilli (AFB) before respiratory isolation is discontinued. Limited data are available to predict the length of ti
An unholy trinity--three negative sputum smears and release from tuberculosis isolation [editorial; comment]: Clin Infect Dis. 1997 Sep;25(3):671-2. Unique Identifier : AIDSLINE /MED97458130; Iseman MD
Candidal meningitis in HIV-infected patients: analysis of 14 cases.: Clin Infect Dis. 1997 Sep;25(3):673-6. Unique Identifier : AIDSLINE /MED97458131; Casado JL; Quereda C; Oliva J; Navas E; Moreno A; Pintado V; Cobo J; Corral I; Department of Infectious Diseases, Hospital Ramon y Cajal, Madrid,; Spain.; Five cases of candidal meningitis in human immunodeficiency virus HIV)-infected patients have been diagnosed in our hospital. This article describes these cases and reviews another nine previously reported in the literature. Most patients (71%) had at least one well-known predisposing factor for candidiasis. Median CD
Focal infections due to non-typhi Salmonella in patients with AIDS: report of 10 cases and review.: Clin Infect Dis. 1997 Sep;25(3):690-7. Unique Identifier : AIDSLINE /MED97458134; Fernandez Guerrero ML; Ramos JM; Nunez A; Nunez A; de Gorgolas M; Division of Infectious Diseases, Fundacion Jimenez Diaz, Universidad; Autonoma de Madrid, Spain.; Bacteremia due to non-typhi Salmonella is frequent in human immunodeficiency virus (HIV)-infected patients; however, focal complications rarely have been reported. Ten of 38 HIV-infected patients (26.3%) with salmonellosis documented over a period of 9 years had focal suppurative complications; only 19 (3.9%) of 490 a
High prevalence of gynecologic disease among hospitalized women with human immunodeficiency virus infection.: Clin Infect Dis. 1997 Sep;25(3):706-12. Unique Identifier : AIDSLINE /MED97458136; Frankel RE; Selwyn PA; Mezger J; Andrews S; AIDS Program, Yale School of Medicine, Yale University, New Haven,; Connecticut 06510, USA.; We offered standardized gynecologic examinations to consecutive women admitted to an AIDS-designated inpatient medical service; 65 (97%) of 67 women consented to the examination. The median CD4+ T lymphocyte count was 54/mm3. Only 9% of the women were admitted for primary gynecologic or genitourinary diagnoses; howeve
Pneumocystis carinii pneumonia in infants who were exposed to human immunodeficiency virus but were not infected: an exception to the AIDS surveillance case definition.: Clin Infect Dis. 1997 Sep;25(3):739-40. Unique Identifier : AIDSLINE /MED97458144; Heresi GP; Caceres E; Atkins JT; Reuben J; Doyle M; Department of Pediatrics, University of Texas Medical School, Houston,; USA.
Herpesvirus-like DNA sequences in Kaposi's sarcoma lesions from two women with AIDS.: Clin Infect Dis. 1997 Sep;25(3):740-1. Unique Identifier : AIDSLINE /MED97458145; Pulik M; Dupin N; Gorin I; Department of Hematology, Centre Hospitalier d'Argenteuil, France.
Disseminated Mycobacterium genavense infection as a cause of pseudo-Whipple's disease and sclerosing cholangitis.: Clin Infect Dis. 1997 Sep;25(3):742-3. Unique Identifier : AIDSLINE /MED97458147; Albrecht H; Rusch-Gerdes S; Stellbrink HJ; Greten H; Jackle S; Medizinische Klinik, Universitatskrenkenhaus Eppendorf, Hamburg,; Germany.
Nephrotic syndrome associated with bacillary angiomatosis in a patient with AIDS.: Clin Infect Dis. 1997 Sep;25(3):750-1. Unique Identifier : AIDSLINE /MED97458153; Newell AM; Francis N; Nelson MR; St. Stephen's Centre, Chelsea and Westminster Hospital, London, United; Kingdom.
Anterior uveitis in a patient with AIDS who was treated with terbinafine for oral candidiasis: a potential drug-induced reaction.: Clin Infect Dis. 1997 Sep;25(3):752-3. Unique Identifier : AIDSLINE /MED97458155; Price T; Stallman J; Dretler RH; Dekalb Medical Center, Georgia Retina, PC, and Infectious Disease; Specialists of Atlanta, Decatur 30033, USA.
A life-threatening adverse reaction during trimethoprim-sulfamethoxazole desensitization in a previously hypersensitive patient infected with human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1997 Sep;25(3):754-6. Unique Identifier : AIDSLINE /MED97458157; Marsh BJ
Amphotericin B-induced hypothermia not proven [letter; comment]: Clin Infect Dis. 1997 Sep;25(3):757. Unique Identifier : AIDSLINE /MED97458159; Craven PC
Nosocomial Clostridium difficile-associated diarrhea in patients with AIDS: a three-year survey and review.: Clin Infect Dis. 1997 Sep;25 Suppl 2:S204-5. Unique Identifier : AIDSLINE /MED97456723; Mastroianni A; Coronado O; Nanetti A; Valentini R; Manfredi R; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Policlinico Sant' Orsola, Universita di Bologna, Italy.
[Differences in laboratory parameters in clinical categories CDC/93) of HIV infection]: An Med Interna. 1997 Aug;14(8):399-402. Unique Identifier : AIDSLINE /MED98021667; Menendez Martinez MA; Perez De Oteyza C; Muro Garcia R; Garcia Cortes A; Pastor Gomez JM; Unidad VIH, Hospital Militar Gomez Ulla, Universidad Complutense,; Madrid.; OBJECTIVE: To establish the difference between the evolutive clinical categories (CDC/93) of the HIV infection, on the basis of diverse laboratory parameters. MATERIAL AND METHOD: 332 samples of blood, from 118 patients with HIV infection revised every three months from 1986, were studied. Determinations: haematologic
[Bone marrow examination in patients with human immunodeficiency virus infection and fever of unknown origin (letter)]: An Med Interna. 1997 Aug;14(8):428-9. Unique Identifier : AIDSLINE /MED98021676; Raya Sanchez JM; Brito Barroso ML; Gomez Sirvent JL; Hernandez Nieto L
[Disseminated histoplasmosis and HIV infection (letter)]: An Med Interna. 1997 Aug;14(8):431-3. Unique Identifier : AIDSLINE /MED98021680; Rodriguez Junquera M; Carcaba Fernandez V; Alfonso Megido J; Velasco Alvarez L; Dominguez Iglesias F
Viral safety of plasma-derived factor VIII and IX concentrates.: Blood Coagul Fibrinolysis. 1997 Aug;8 Suppl 1:S19-23. Unique Identifier : AIDSLINE /MED98011897; Ludlam CA; Department of Haematology, Royal Infirmary of Edinburgh NHS Trust,; Edinburgh, UK.; Treatment, or prevention, of bleeding in severe haemophilia requires lifelong therapy with repeated injections of factor VIII/IX concentrate which carry a risk of viral infection. The overall safety of all blood products depends not only upon careful donor selection and the screening of donations for infectious viruse
Who should receive recombinant factor VIII?: Blood Coagul Fibrinolysis. 1997 Aug;8 Suppl 1:S25-7. Unique Identifier : AIDSLINE /MED98011898; Giangrande PL; Oxford Haemophilia Centre, Churchill Hospital, UK.; Recent guidelines published by the United Kingdom Haemophilia Centre Directors Organisation state that recombinant factor VIII constitutes the treatment of choice for all patients with haemophilia A. However, certain categories may have to be accorded priority as financial resources a
Transport properties of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine in the rat choroid plexus.: Biopharm Drug Dispos. 1997 Oct;18(7):611-22. Unique Identifier : AIDSLINE /MED97471840; Takasawa K; Suzuki H; Sugiyama Y; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences,; University of Tokyo, Japan.; Transport properties of 3 -azido-3 -deoxythymidine ( AZT ) and 2 ,3 -dideoxyinosine (DDI) were characterized in the isolated rat choroid plexus. AZT and DDI competitively inhibited the active transport of [3H]benzylpenicillin, a prototypic organic anion
Isolation, characterization and molecular cloning of a leaf-specific lectin from ramsons (Allium ursinum L.).: Plant Mol Biol. 1997 Nov;35(4):531-5. Unique Identifier : AIDSLINE /MED98009988; Smeets K; Van Damme EJ; Van Leuven F; Peumans WJ; Laboratory for Phytopathology and Plant Protection, Katholieke; Universiteit Leuven, Belgium.; Lectins were isolated from roots and leaves of ramsons and compared to the previously described bulb lectins. Biochemical analyses indicated that the root lectins AUAIr and AUAIIr are identical to the bulb lectins AUAI and AUAII, whereas the leaf lectin AUAL has no counterpart in the bulbs. cDNA cloning confirmed that
The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription.: Semin Cancer Biol. 1997 Apr;8(2):121-9. Unique Identifier : AIDSLINE /MED97445684; Mosialos G; Infectious Disease Division, Brigham & Women's Hospital, Harvard; Medical School, Boston, MA 02115, USA.; Rel/NF-kappa B is a ubiquitous transcription factor that consists of multiple polypeptide subunits, and is subject to complex regulatory mechanisms that involve protein-protein interactions, phosphorylation, ubiquitination, proteolytic degradation, and nucleocytoplasmic translocation. The sophisticated control of Rel/
IL-12 as an adjuvant for cell-mediated immunity.: Semin Immunol. 1997 Oct;9(5):285-91. Unique Identifier : AIDSLINE /MED97468436; Scott P; Trinchieri G; Department of Pathobiology, University of Pennsylvania School of; Veterinary Medicine, Philadelphia 19104, USA.; Recent studies have shown that IL-12 initiates the development of cell-mediated immunity following infection with certain infectious agents. This attribute of IL-12 makes it a potentially effective adjuvant for vaccines. This review summarizes our findings in the Leishmania system, outlining the role of endogenous IL-
Challenges for vaccination against sexually-transmitted diseases: induction and long-term maintenance of mucosal immune responses in the female genital tract.: Semin Immunol. 1997 Oct;9(5):303-14. Unique Identifier : AIDSLINE /MED97468438; Rosenthal KL; Gallichan WS; Department of Pathology, McMaster University Health Sciences Centre,; Hamilton, Ontario, Canada.; The ability to develop vaccines capable of preventing or protecting against sexually transmitted viruses, such as herpes simplex virus (HSV) and HIV is likely to depend on the induction of long-term mucosal immune responses. We have utilized a recombinant adenovirus capable of expressing HSV glycoprotein B AdgB8) to d
The office of national AIDS policy: a new director offers new hope [editorial]: J Assoc Nurses AIDS Care. 1997 Sep-Oct;8(5):16-7. Unique Identifier : AIDSLINE /MED97443673; Sowell RL
Needle and syringe exchange: pride and prejudice.: J Assoc Nurses AIDS Care. 1997 Sep-Oct;8(5):18-20. Unique Identifier : AIDSLINE /MED97443674; Bradley-Springer L
Psychosocial predictors of life satisfaction among persons living with HIV infection and AIDS.: J Assoc Nurses AIDS Care. 1997 Sep-Oct;8(5):21-30. Unique Identifier : AIDSLINE /MED97443675; Heckman TG; Somlai AM; Sikkema KJ; Kelly JA; Franzoi SL; Center for AIDS Intervention Research, Medical College of Wisconsin,; USA.; As AIDS becomes a more chronic but manageable illness, understanding quality of life issues among persons living with this disease has become an important goal of health care researchers. However, most quality of life investigations of persons living with HIV disease have relied heavily on clinical samples (e.g., hosp
HIV RNA quantitation: marker of HIV infection.: J Assoc Nurses AIDS Care. 1997 Sep-Oct;8(5):31-8. Unique Identifier : AIDSLINE /MED97443676; Melroe NH; Stawarz KE; Simpson J; Henry WK; HIV Program at St. Paul Ramsey Medical Center, USA.; Assessment of the status and prognosis of an HIV-infected individual traditionally has been difficult for the clinician. The use of markers of disease progression such as CD4+ has been found to not be a complete indicator of the status of an HIV-infected individual. As a result, determining appropriate therapy for the
Malnutrition associated with HIV/AIDS. Part Two: Assessment and interventions.: J Assoc Nurses AIDS Care. 1997 Sep-Oct;8(5):39-48. Unique Identifier : AIDSLINE /MED97443677; Casey KM; Nutritional deficits can be forestalled through early assessment and intervention. Appropriate treatment may alter the continuum of deterioration and improve a patient s quality of life. This article reviews the comprehensive nutritional assessment, the adoption of screening tools, and the multidisciplinary, multimoda
Characteristics of volunteer participants in phase I HIV vaccine trials.: J Assoc Nurses AIDS Care. 1997 Sep-Oct;8(5):59-65. Unique Identifier : AIDSLINE /MED97443678; Crumbo CL; Rybczyk GK; Wagner LJ; AIDS Vaccine Evaluation Unit, Vanderbilt University Medical Center,; USA.; This study examines characteristics of volunteers participating in Phase I HIV vaccine trials. An understanding of these characteristics may assist in the recruitment of volunteers for future trials. Volunteer surveys from 232 participants were reviewed. A total of 95% of the volunteers were Caucasian, 69% were hetero
Nursing considerations in the use of cidofovir for CMV retinitis in patients with AIDS: report of a roundtable meeting.: J Assoc Nurses AIDS Care. 1997 Sep-Oct;8(5):66-74. Unique Identifier : AIDSLINE /MED97443679; Martin MA; Kane C; Department of Medicine, UCLA Medical Center, USA.; Cytomegalovirus ( CMV ) retinitis, a late complication of infection with HIV, generally leads to blindness if untreated. Although the retinal damage from CMV cannot be reversed, disease progression can be arrested with any one of three antiviral agents, which must
Magic Johnson and Lazarus: the new syndromes.: J Assoc Nurses AIDS Care. 1997 Sep-Oct;8(5):75-6. Unique Identifier : AIDSLINE /MED97443680; Gregonis SW; Allegheny University of the Health Sciences.
[Value of high-resolution CT of the lungs in acute pulmonary symptoms of patients with HIV infections]: Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 1997 Sep;167(3):227-33. Unique Identifier : AIDSLINE /MED98014730; Diehl SJ; Lehmann KJ; Thienel F; Georgi M; Institut fur Klinische Radiologie, Fakultat fur Klinische Medizin; Mannheim, Universitat Heidelberg.; PURPOSE: The purpose of this study was to assess the clinical value of HRCT of the lung in patients with known HIV-infection and acute lung disease. In a prospective study a HRCT was performed in 31 patients infected with the HIV-1 virus, mainly stage C (CDC), who had acute pulmonary symptoms. Precondition for the HRC
Contamination incidents among doctors and midwives: reasons for non-reporting and knowledge of risks.: Occup Med (Oxf). 1997 Aug;47(6):357-60. Unique Identifier : AIDSLINE /MED97468552; Burke S; Madan I; Department of Occupational Health and Safety, Southmead Health; Services NHS Trust, Westbury on Trym, Bristol, UK.; A 6-month retrospective self-administered questionnaire study of 482 doctors and 380 midwives in two NHS Trusts was undertaken. The response rate was 384 (80%) and 293 (77%) respectively. The study revealed that only nine per cent of doctors and 46% of midwives had reported the contamination incidents they had receive
Dysregulation of membrane-bound tumor necrosis factor-alpha and tumor necrosis factor receptors on mononuclear cells in human immunodeficiency virus type 1 infection: low percentage of p75-tumor necrosis factor receptor positive cells in patients with advanced disease and high viral load.: Blood. 1997 Oct 1;90(7):2670-9. Unique Identifier : AIDSLINE /MED97465514; Hestdal K; Aukrust P; Muller F; Lien E; Bjerkeli V; Espevik T; Froland SS; Department of Pediatric Research, University of Oslo, The National; Hospital, Norway.; The correlation of persistent tumor necrosis factor-alpha TNF-alpha) activation with disease progression in patients infected with human immunodeficiency virus type 1 (HIV-1), suggests a role for TNF-alpha in the pathogenesis of HIV-1 infection. In the present study, we examined by flow cytometry the expression of mem
Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients.: Blood. 1997 Oct 1;90(7):2826-9. Unique Identifier : AIDSLINE /MED97465531; Parravicini C; Olsen SJ; Capra M; Poli F; Sirchia G; Gao SJ; Berti E; Nocera A; Rossi E; Bestetti G; Pizzuto M; Galli M; Moroni M; Moore PS; Corbellino M; Department of Pathology, Ospedale L. Sacco, Milano, Italy.; Kaposi s sarcoma-associated herpesvirus (KSHV) is a newly discovered herpes virus found in all forms of Kaposi s sarcoma KS) including KS among immunosuppressed transplant patients. It is unknown whether this virus is transmitted by organ transplantation or is reactivated during immunosuppression among those patients
Hemophiliacs with nonprogressive human immunodeficiency virus disease [letter]: Blood. 1997 Oct 1;90(7):2846-8. Unique Identifier : AIDSLINE /MED97465536; Jimeenez-Yuste V; Hernandez-Navarro F; Magallon M; Bernal A; Garcia Saiz A
Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1.: Blood. 1997 Oct 15;90(8):3142-53. Unique Identifier : AIDSLINE /MED98025899; Tsukada J; Misago M; Serino Y; Ogawa R; Murakami S; Nakanishi M; Tonai S; Kominato Y; Morimoto I; Auron PE; Eto S; First Department of Internal Medicine, School of Medicine and the; School of Health Sciences, University of Occupational and; Environmental Health, Kitakyushu, Japan.; The human T-cell leukemia virus type I (HTLV-I), which infects a wide variety of mammalian cells including monocytes and macrophages, encodes a transactivating protein designated as Tax. We now report that Tax induces the human prointerleukin-1beta IL1B) gene promoter in monocytic cells. In our transient transfection
Antitumor effects of nonconjugated murine Lym-2 and human-mouse chimeric CLL-1 monoclonal antibodies against various human lymphoma cell lines in vitro and in vivo.: Blood. 1997 Oct 15;90(8):3160-6. Unique Identifier : AIDSLINE /MED98025901; Funakoshi S; Hirano A; Beckwith M; Asai O; Jorgensen G; Tian Z; Hornick JL; Hu P; Khawli LA; Epstein AL; Longo DL; Murphy WJ; Division of Basic Sciences, Intramural Research Support Program, SAIC; Frederick, National Cancer Institute-Frederick Cancer Research and; Development Center, MD 21702-1201, USA.; Lym-2 is a murine monoclonal antibody (MoAb) directed towards a human class II molecule variant reactive with both normal and neoplastic human B lymphocytes. Previous studies have shown that signals transmitted by class II molecules that stimulate normal lymphocytes can be inhibitory for B-cell lymphoma growth by sign
Increased enzymatic activity of the T-cell antigen receptor-associated fyn protein tyrosine kinase in asymptomatic patients infected with the human immunodeficiency virus.: Blood. 1997 Nov 1;90(9):3603-12. Unique Identifier : AIDSLINE /MED98008125; Phipps DJ; Yousefi S; Branch DR; Department of Oncology Research, The Toronto Hospital Research; Institute, Toronto, Ontario, Canada.; The immune system of patients infected with human immunodeficiency virus (HIV) is in a state of chronic activation; however, the nature of HIV-related immune activation is unknown. As normal T-cell activation involves early tyrosine phosphorylation induced by the T-cell antigen receptor-associated src-family protein t
Molecular mimicry between the rabies virus glycoprotein and human immunodeficiency virus-1 GP120: cross-reacting antibodies induced by rabies vaccination.: Blood. 1997 Nov 1;90(9):3623-8. Unique Identifier : AIDSLINE /MED98008127; Bracci L; Ballas SK; Spreafico A; Neri P; Department of Molecular Biology, University of Siena, Policlinico Le; Scotte, Siena, Italy.; The 160-170 sequence of human immunodeficiency virus (HIV)-1 gp120 mimics a nicotinic receptor-binding motif of rabies virus glycoprotein and snake neurotoxins. This sequence has been proposed to be involved in the binding of HIV-1 gp120 to the acetylcholine binding sites of nicotinic receptors. By using biomolecular
Human immunodeficiency virus-1 env impairs Fc receptor-mediated phagocytosis via a cyclic adenosine monophosphate-dependent mechanism.: Blood. 1997 Nov 1;90(9):3760-5. Unique Identifier : AIDSLINE /MED98008144; Thomas CA; Weinberger OK; Ziegler BL; Greenberg S; Schieren I; Silverstein SC; El Khoury J; Department of Physiology and Cellular Biophysics, Howard Hughes; Medical Institute, Columbia University, New York, NY 10032, USA.; Human immunodeficiency virus (HIV)-1 expression in mononuclear phagocytes is associated with multiple functional defects, including phagocytosis. To assess Fcgamma receptor (FcgammaR) function in cells expressing HIV-1, human promonocytic cells U937) acutely or chronically infected with HIV-1, or stably transfected wi
[HIV/AIDS counseling services for foreigners at the Shinjuku Public Health Center]: Nippon Koshu Eisei Zasshi. 1997 May;44(5):391-9. Unique Identifier : AIDSLINE /MED97404448; Nakanishi Y; Saito N; Morita R; Oyama Y; Jitthai N; Kihara M; Shinjuku Public Health Center.; Since October 1994, the Shinjuku Public Health Center in collaboration with an NGO, has offered AIDS counseling services for foreigners. Although the NGO operated with volunteers before July 1995, the Center began budgeted HIV/AIDS counseling for foreigners from July 1995. The pre-HIV test counseling and post-test cou
[Current status of HIV infection in Yunnan Province of China]: Nippon Koshu Eisei Zasshi. 1997 May;44(5):400-10. Unique Identifier : AIDSLINE /MED97404449; Hirabayashi K; Tajima K; Soda K; Yi Z; Dong ZX; He CH; Lin YG; Expert Service Division, International Medical Center of Japan.; In cooperation with the Chinese Academy of Preventive Medicine and Yunnan Province Provincial Office for AIDS Control and Prevention, we studied the current status of HIV infection intravenous drug users (IVDUs) and other high risk groups in Yunnan province of China . As of the end o
[The HIV/AIDS Epidemic in Cambodia]: Nippon Koshu Eisei Zasshi. 1997 May;44(5):411-8. Unique Identifier : AIDSLINE /MED97404450; Soda K; Morio S; Tajima K; Kitamura K; Toba M; Ito A; Kihara M; Ichikawa S; Imai M; Mizushima S; Ohshige K; Department of Public Health, Yokohama City University School of; Medicine, Japan.; In December 1995 and March 1996, we visited institutes which were conducting epidemiological studied of HIV/AIDS in Cambodia , and obtained data for further collaborative study between Japan and Cambodia. Data included information on AIDS patien
Stability of treatment preferences: although most preferences do not change, most people change some of their preferences.: J Clin Ethics. 1997 Summer;8(2):124-35. Unique Identifier : AIDSLINE /MED97448220; Kohut N; Sam M; O'Rourke K; MacFadden DK; Salit I; Singer PA; University of Toronto Joint Centre for Bioethics, Ontario, Canada.
The effect of ethnicity on ICU use and DNR orders in hospitalized AIDS patients.: J Clin Ethics. 1997 Summer;8(2):150-7. Unique Identifier : AIDSLINE /MED97448222; Tulsky JA; Cassileth BR; Bennett CL; Center for Health Services Research in Primary Care, VA Medical; Center, Durham, NC, USA.
Legal trends in bioethics.: J Clin Ethics. 1997 Summer;8(2):204-7. Unique Identifier : AIDSLINE /MED97448231; Davis DS; Cleveland-Marshall College of Law, Cleveland State University, OH,; USA.
The historical background of the control of enzootic bovine leukosis in Estonia.: Rev Sci Tech. 1996 Sep;15(3):1007-20. Unique Identifier : AIDSLINE /MED97177636; Viltrop A; Laht T; Veterinary Research Centre, Estonian University of Agriculture, Tartu,; Estonia.; The authors describe the history of enzootic bovine leukosis EBL) in Estonia , including the occurrence and distribution of disease within the cattle population, and the factors which have influenced disease spread since the 1950s. The principles of various control schemes which we
Cat-scratch disease and bacillary angiomatosis.: Rev Sci Tech. 1996 Sep;15(3):1061-73. Unique Identifier : AIDSLINE /MED97177641; Chomel BB; Department of Population Health and Reproduction, School of Veterinary; Medicine, University of California, Davis 95616, USA.; Cat-scratch disease (CSD) was first described by Debre in 1950, yet the causative bacterial agent of CSD remained obscure until 1992, when Bartonella (formerly Rochalimaea) henselae was implicated in CSD by serological and microbiological studies. B. henselae had initially been linked to
The effect of fixation type on DNA extracted from paraffin-embedded tissue for PCR studies in dermatopathology.: Dermatology. 1997;195(2):105-7. Unique Identifier : AIDSLINE /MED97456757; Alaibac M; Filotico R; Giannella C; Paradiso A; Labriola A; Marzullo F; Laboratory of Experimental Oncology, National Cancer Institute, Bari,; Italy.; BACKGROUND: Amplification of nucleic acids from paraffin-embedded material by the polymerase chain reaction (PCR) is widely used to detect viral genomes, clonal gene rearrangements and oncogene mutations in skin specimens. Fixation with embedding of skin tissue is a procedure that has a profound effect on its molecula
Kaposi's sarcoma: the efficacy of a single fraction of 800 cGy.: Dermatology. 1997;195(2):142-4. Unique Identifier : AIDSLINE /MED97456765; Yildiz F; Ozyar E; Uzal D; Sahin S; Atahan IL; Department of Radiation Oncology, Hacettepe University, Faculty of; Medicine, Ankara, Turkey.; BACKGROUND: Although Kaposi s sarcoma is the most common neoplasm in association with AIDS, classic Kaposi s sarcoma is rare. The best treatment modality is still unclear. METHODS: Between December 1993 and December 1995, 42 fields in 12 patients with Kaposi s sarcoma were treated at our department. Only 3 patients ha
Preservation of allergic contact dermatitis to poison ivy urushiol) in late HIV disease. The implications and relevance to immunotherapy with contact allergens.: Dermatology. 1997;195(2):145-9. Unique Identifier : AIDSLINE /MED97456766; Smith KJ; Skelton HG; Nelson A; Wagner KF; Hackley BE Jr; National Naval Medical Center, Department of Dermatology, Bethesda, MD; 20814, USA.; BACKGROUND: Delayed hypersensitivity reactions (DTH) are lost with progression of HIV disease. This loss of DTH commonly occurs before the onset of opportunistic infections and is an independent predictor of disease progression. OBJECTIVE: We wanted to determine whether patients in late HIV disease with a history of a
Adult T-cell leukemia/lymphoma presenting with digital gangrene.: Dermatology. 1997;195(2):150-2. Unique Identifier : AIDSLINE /MED97456767; Setoyama M; Yamamoto S; Kanzaki T; Department of Dermatology, Faculty of Medicine, Kagoshima University,; Japan.; There have been only a few reports in the literature of lymphoma patients suffering from digital gangrene. The present case, a 40-year old man with adult T-cell leukemia/lymphoma (ATLL) showed marked edematous and dyshidrosis-like changes of the digital fingers. As a result of these changes, most of the fingertips of
Indinavir sulfate renal toxicity in a pediatric hemophiliac with HIV infection.: Ann Pharmacother. 1997 Oct;31(10):1146-9. Unique Identifier : AIDSLINE /MED97478595; Ascher DP; Lucy MD; Department of Pediatrics, Wilford Hall Medical Center, San Antonio,; TX, USA.; OBJECTIVE: To report a case of renal toxicity associated with administration of indinavir sulfate in a pediatric hemophiliac with HIV infection. CASE SUMMARY: A 16-year-old white hemophiliac boy with HIV infection secondary to tainted coagulation factor VIII was treated with indinavir sulfate. The patient developed gr
Idiopathic CD4+ T-lymphocytopenia in a non-Hodgkin's lymphoma patient.: Intern Med. 1997 Sep;36(9):643-6. Unique Identifier : AIDSLINE /MED97458290; Hanamura I; Wakita A; Harada S; Tsuboi K; Komatsu H; Banno S; Iwaki O; Takeuchi G; Nitta M; Ueda R; Second Department of Internal Medicine, Nagoya City University Medical; School.; We report a case of idiopathic CD4+ T-lymphocytopenia with malignant lymphoma (diffuse large, B-cell type) for which there was no evidence of human immunodeficiency virus type 1 or type 2 infection and no other known causes of immunodeficiency. She had never suffered from any opportunistic infection until the diagnosi
[Acute retinal necrosis. Silicon oil tamponade in retinal detachment]: Ophthalmologe. 1997 Aug;94(8):568-72. Unique Identifier : AIDSLINE /MED97465203; Stoffelns B; Pfeiffer N; Augenklinik, Johannes-Gutenberg-Universitat, Mainz.; BACKGROUND: Because retinal necrosis syndrome seldom occurs, we present our results of silicone oil tamponade for associated retinal detachment. PATIENTS AND METHODS: Thirteen eyes from 13 patients undergoing retinal reattachment surgery for retinal detachment associated with acute retinal necrosis in a consecutive se
Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease.: Int Arch Allergy Immunol. 1997 Oct;114(2):103-10. Unique Identifier : AIDSLINE /MED97478307; Brener Z; Gazzinelli RT; Centro de Pesquisas Rene Rachou-Fiocruz, Belo Horizonte, MG, Brazil.; The major goal of studies on immunity to Trypanosoma cruzi is the understanding of immunological mechanisms involved in resistance to this protozoan as well as the pathogenesis of Chagas disease. Different studies have defined CD8+ T lymphocytes, IFN-gamma and macrophages as important elements controlling parasite re
Interleukin 7 and sCD23 synergize in the induction of human T cell activation in HIV-1-infected subjects.: Int Arch Allergy Immunol. 1997 Oct;114(2):120-9. Unique Identifier : AIDSLINE /MED97478310; Fratazzi C; Guerriero M; Carini C; Department of Medicine, Harvard Medical School, Boston, Mass., USA.; The role played by CD23 in retroviral infections is still unclear. The synergistic effects of interleukin 7 (IL-7) and sCD23 on T cell proliferation and the generation of HIV-1-specific cytotoxic T lymphocytes (CTL) in mitogen- and antigen-stimulated systems were examined. Addition of IL-7 and sCD23 at the onset of cu
Molecular cloning and expression of cynomolgus monkey interferon-gamma cDNA.: Int Arch Allergy Immunol. 1997 Nov;114(3):229-36. Unique Identifier : AIDSLINE /MED98028533; Tatsumi M; Sata T; Department of Veterinary Science, AIDS Research Center, National; Institute of Infectious Diseases, Tokyo, Japan.; Since the discovery of its involvement in the pathogenesis of simian immunodeficiency virus infection, the role of macaque monkey interferon-gamma (IFNgamma) has been a focus of particular interest. The purpose of this study was to express bioactive recombinant monkey IFNgamma, as well as clone cynomolgus monkey IFNga
Mortality associated with HIV-1 infection over five years in a rural Ugandan population: cohort study.: BMJ. 1997 Sep 27;315(7111):767-71. Unique Identifier : AIDSLINE /MED98004926; Nunn AJ; Mulder DW; Kamali A; Ruberantwari A; Kengeya-Kayondo JF; Whitworth J; Medical Research Programme on AIDS in Uganda, Uganda Virus Research; Institute, Entebbe. ajn@mrc.ucl.ac.uk; OBJECTIVE: To assess the impact of HIV-1 infection on mortality over five years in a rural Ugandan population. DESIGN: Longitudinal cohort study followed up annually by a house to house census and medical survey. SETTING: Rural population in south west Uganda. SUBJECTS: About 10,000 people from 15 villages who were en
HIV antibody assay that gave false negative results: multicentre collaborative study.: BMJ. 1997 Sep 27;315(7111):772-4. Unique Identifier : AIDSLINE /MED98004927; Evans BG; Parry JV; Mortimer PP; Public Health Laboratory Service, London. bevans@phls.co.uk; OBJECTIVE: To identify false negative results arising from the use of a commercial kit to detect antibody to HIV-1 and HIV-2 between July 1995 and March 1996. DESIGN: The 56 laboratories in the United Kingdom that were using the assay were asked to retrieve and retest specimens with an
Doctors volunteer to be guinea pigs for AIDS vaccine [news]: BMJ. 1997 Oct 4;315(7112):833. Unique Identifier : AIDSLINE /MED98014823; Josefson D
HIV treatment in children brought into line with that in adults [news]: BMJ. 1997 Oct 11;315(7113):902. Unique Identifier : AIDSLINE /MED98027608; Josefson D
Inequality in funding for AIDS across England threatens regional services [letter]: BMJ. 1997 Oct 11;315(7113):950-1. Unique Identifier : AIDSLINE /MED98027630; Bellis MA; McCullagh J; Thomson R; Regan D; Syed Q; Kelly T
HIV infection among victims of accidental fatal drug overdoses in New York City.: Addiction. 1997 Aug;92(8):1017-22. Unique Identifier : AIDSLINE /MED98025957; Tardiff K; Marzuk PM; Leon AC; Hirsch CS; Portera L; Hartwell N; Department of Psychiatry, Cornell University Medical College, New York; 10021, USA.; AIMS: To determine the factors associated with HIV seroprevalence rates for victims of drug overdoses. DESIGN: Descriptive epidemiologic survey of a complete 3-year sample of accidental fatal drug overdoses. SETTING: New York City (population 7,322,564). PARTICIPANTS: All people over 15 years of age (n = 2159) who die
Methadone maintenance and hepatitis C virus infection among injecting drug users.: Addiction. 1997 Aug;92(8):999-1005. Unique Identifier : AIDSLINE /MED98025955; Crofts N; Nigro L; Oman K; Stevenson E; Sherman J; Macfarlane Burnet Centre for Medical Research, Victoria, Australia.; crofts@mbcmr.unimelb.edu.au; Harm reduction strategies for the prevention of transmission of human immunodeficiency virus (HIV) transmission among injecting drug users (IDUs) have been widely implemented in Australia and are seen to have been effective in preventing the spread of HIV. A major strategy has b
Immune activation in cervical neoplasia: cross-sectional association between plasma soluble interleukin 2 receptor levels and disease.: Cancer Epidemiol Biomarkers Prev. 1997 Oct;6(10):807-13. Unique Identifier : AIDSLINE /MED97473921; Hildesheim A; Schiffman MH; Tsukui T; Swanson CA; Lucci J 3rd; Scott DR; Glass AG; Rush BB; Lorincz AT; Corrigan A; Burk RD; Helgesen K; Houghten RA; Sherman ME; Kurman RJ; Berzofsky JA; Kramer TR; Division of Cancer Epidemiology and Genetics, National Cancer; Institute, Bethesda, Maryland 20892, USA. Hildesha@epndce.nci.nih.gov; In a previous study (Tsukui et al., Cancer Res., 56: 3967-3974, 1996), we observed an inverse association between degree of cervical neoplasia and interleukin (IL) 2 production by peripheral blood mononuclear cells in response to human papillomavirus (HPV) 16 E6 and E7 peptides in vitro. This suggested that a Th1-medi
Deletion variants within the NF-kappaB activation domain of the LMP1 oncogene in acquired immunodeficiency syndrome-related large cell lymphomas, in prelymphomas and atypical lymphoproliferations.: Leuk Lymphoma. 1997 Jul;26(3-4):239-50. Unique Identifier : AIDSLINE /MED97462659; Berger C; Brousset P; McQuain C; Knecht H; LINK Laboratories at the Cancer Center, University of Massachusetts; Medical Center, North Worcester 01655-0246, USA.; The latent membrane protein 1 (LMP1) oncogene of Epstein Barr virus (EBV) is expressed in tumor cells of acquired immunodeficiency syndrome (AIDS) related lymphomas, HIV-negative, EBV-associated malignant lymphoproliferations, nasopharyngeal carcinoma, as well as in reactive immunoblasts of infectious mononucleosis. N
Frequent hepatic involvement in adult T cell leukemia: comparison with non-Hodgkin's lymphoma.: Leuk Lymphoma. 1997 Jul;26(3-4):327-35. Unique Identifier : AIDSLINE /MED97462668; Yamada Y; Kamihira S; Murata K; Yamamura M; Maeda T; Tsukasaki K; Jubash T; Atogami S; Sohda H; Taguchi T; Tomonaga M; Department of Laboratory Medicine, Atomic Disease Institute, Nagasaki; University School of Medicine, Japan.; We examined 111 patients with acute type- or lymphoma type-adult T-cell leukemia (ATL) and compared them with 106 patients with non-Hodgkin s lymphoma (NHL). In addition to skin involvement and hypercalcemia which are already known to be frequent in ATL, ATL patients showed an high
Autologous stem cell infusion for acute myeloblastic leukemia in an HIV-1 carrier.: Bone Marrow Transplant. 1997 Oct;20(7):611-2. Unique Identifier : AIDSLINE /MED97477002; Schneider E; Lambermont M; Van Vooren JP; Bastin G; Feremans W; Kentos A; Lemoine F; Liesnard C; Delforge ML; Crenier L; Capel P; Farber CM; Clinic of Haematology, Hopital Erasme, Brussels, Belgium.; We present the case of an asymptomatic HIV carrier, who presented with acute myeloblastic leukemia in third relapse and successfully underwent autologous stem cell transplantation as a rescue treatment. This observation supports the conclusion that tolerance of autologous bone marrow or stem cell transplant in patient
Positive role of macaque cytotoxic T lymphocytes during SIV infection: decrease of cellular viremia and increase of asymptomatic clinical period.: FEMS Immunol Med Microbiol. 1997 Sep;19(1):81-7. Unique Identifier : AIDSLINE /MED97463288; Villada IB; Mortara L; Aubertin AM; Gras-Masse H; Levy JP; Guillet JG; Institut Cochin de Genetique Moleculaire, Laboratoire d'Immunologie; des Pathologies Infectieuses et Tumorales, Universite Rene Descartes,; Hopital Cochin, Paris, France.; We have measured cellular viremia and observed clinical outcome of macaques from two cohorts, the first including 12 macaques infected by SIVmac251 and the second including 12 macaques immunized by lipopeptides and then challenged by SIVmac251. In the first cohort (SIV-infected macaques), 3 patterns of CTL responders
Assessing Health-Related Quality of Life in Early HIV Disease. Proceedings of a meeting. Paris, France, 1-2 October 1996.: Qual Life Res. 1997 Aug;6(6):469-605. Unique Identifier : AIDSLINE /MED97471605
Current antiretroviral therapy: an overview.: Qual Life Res. 1997 Aug;6(6):471-4. Unique Identifier : AIDSLINE /MED97471606; Gulick RM; Division of Infectious Disease, New York University School of; Medicine, NY 10016, USA.; Advances in the understanding of human immunodeficiency virus HIV) pathogenesis, clinical assessment with viral load testing and the availability of potent combination antiretroviral therapy regimens have led to significant changes in options for HIV-infected patients. From the first approved antiretroviral agent, zid
Assessing health-related quality of life in HIV disease: key measurement issues.: Qual Life Res. 1997 Aug;6(6):475-80. Unique Identifier : AIDSLINE /MED97471607; Shumaker SA; Ellis S; Naughton M; Department of Public Health Sciences, Bowman Gray School of Medicine,; Wake Forest University, Winston-Salem, NC 27157-1063, USA.; The reliable and valid assessment of health-related quality of life (HRQoL) in human immunodeficiency virus (HIV) clinical research presents both familiar and unique challenges. Consistent with HRQoL research in general, measures of HRQoL in HIV disease must meet a set of standard psychometric properties, produce inte
Evidence for reliability, validity and usefulness of the Medical Outcomes Study HIV Health Survey (MOS-HIV).: Qual Life Res. 1997 Aug;6(6):481-93. Unique Identifier : AIDSLINE /MED97471608; Wu AW; Revicki DA; Jacobson D; Malitz FE; Department of Health Policy and Management, School of Hygiene and; Public Health, Johns Hopkins University, Baltimore, MD, USA.; awu@hsr.jhsph.edu; The Medical Outcomes Study HIV Health Survey (MOS-HIV) is a brief, comprehensive measure of health-related quality of life HRQoL) used extensively in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). The 35-item questionnaire includes ten dimensions (health perceptions, pain, physical, role,
Assessment of quality of life in early stage HIV-infected persons: data from the AIDS Time-oriented Health Outcome Study ATHOS).: Qual Life Res. 1997 Aug;6(6):494-506. Unique Identifier : AIDSLINE /MED97471609; Lubeck DP; Fries JF; Department of Medicine, Stanford University, CA, USA.; The development of new pharmaceutical interventions for persons with human immunodeficiency virus (HIV) infection has resulted in extended survival and a need for valid, reliable and responsive instruments to assess health-related QoL (HRQoL). This paper reviews the reliability and validity of an HRQoL instrument, the
The Quality of Well-Being scale in asymptomatic HIV-infected patients. HNRC Group. HIV Neural Behavioral Research Center.: Qual Life Res. 1997 Aug;6(6):507-14. Unique Identifier : AIDSLINE /MED97471610; Kaplan RM; Patterson TL; Kerner DN; Atkinson JH; Heaton RK; Grant I; Department of Family and Preventive Medicine, University of; California, San Diego, USA.; We review applications of the Quality of Well-Being (QWB) scale for use in studies of human immunodeficiency virus (HIV)-infected patients. The QWB scale is a preference-weighted decision theory-based measure that summarizes outcomes in terms of quality-adjusted life years (QALYs). In order to validate the QWB scale f
Measuring quality of life in early HIV disease: the modular approach.: Qual Life Res. 1997 Aug;6(6):515-30. Unique Identifier : AIDSLINE /MED97471611; Lenderking WR; Testa MA; Katzenstein D; Hammer S; Phase V Technologies, Inc., Wellesley, MA 02181, USA.; RATIONALE: to examine the reliability and validity of the General Health Self-assessment, a modular questionnaire for self-assessment of quality of life (QoL) in human immunodeficiency virus (HIV) clinical trials and to describe the baseline QoL of participants in a large HIV clinical trial. DESIGN: the domains assess
Applications of the Medical Outcomes Study health-related quality of life measures in HIV/AIDS.: Qual Life Res. 1997 Aug;6(6):531-54. Unique Identifier : AIDSLINE /MED97471612; Wu AW; Hays RD; Kelly S; Malitz F; Bozzette SA; Department of Health Policy and Management, School of Hygiene and; Public Health, Johns Hopkins University, Baltimore, MD, USA.; awu@hsr.jhsph.edu; The leading health status instruments in human immunodeficiency virus (HIV) research are based on the pool of items developed as part of the Medical Outcomes Study (MOS). The measures include the SF-20, MOS-HIV, SF-36, SF-12, SF-56, SF-38 (Patient Reported Status and Experience Survey (PARSE)), SF-21 and HIV Cost and
Use of the MQoL-HIV with asymptomatic HIV-positive patients.: Qual Life Res. 1997 Aug;6(6):555-60. Unique Identifier : AIDSLINE /MED97471613; Smith KW; Avis NE; Mayer KH; Swislow L; New England Research Institutes, Watertown, MA 02172, USA.; kevins@neri.org; The purpose of this study was to determine the appropriateness of the recently developed Multidimensional Quality of Life Questionnaire for HIV/AIDS (MQoL-HIV) as a measure of quality of life (QoL) in cases of asymptomatic human immunodeficiency virus HIV) infection. The MQoL-HIV is a 40-item instrument measuring ten
Performance of a new, HIV/AIDS-targeted quality of life (HAT-QoL) instrument in asymptomatic seropositive individuals.: Qual Life Res. 1997 Aug;6(6):561-71. Unique Identifier : AIDSLINE /MED97471614; Holmes WC; Shea JA; Division of General Internal Medicine, Center for Clinical; Epidemiology and Biostatistics, University of Pennsylvania School of; Medicine, Philadelphia 19104-6021, USA.; OBJECTIVE: To evaluate the psychometric performance of a new human immunodeficiency virus/acquired immune deficiency syndrome HIV/AIDS)-targeted quality of life (QoL) instrument in asymptomatic HIV-seropositive individuals. METHODS: 201 urban and rural, HIV-seropositive subjects were recruited to complete a 76-item pi
Psychometric validation of the revised Functional Assessment of Human Immunodeficiency Virus Infection (FAHI) quality of life instrument.: Qual Life Res. 1997 Aug;6(6):572-84. Unique Identifier : AIDSLINE /MED97471615; Peterman AH; Cella D; Mo F; McCain N; Center on Outcomes, Research and Education, Evanston Northwestern; Healthcare, IL 60201, USA.; The revised Functional Assessment of Human Immunodeficiency Virus Infection (FAHI) quality of life (QoL) instrument has been updated and expanded to provide more complete and accurate coverage of human immune deficiency virus/acquired immune deficiency syndrome (HIV/AIDS)-related QoL. Factor analysis and the Rasch mea
Measuring quality of life from the point of view of HIV-positive subjects: the HIV-QL31.: Qual Life Res. 1997 Aug;6(6):585-94. Unique Identifier : AIDSLINE /MED97471616; Leplege A; Rude N; Ecosse E; Ceinos R; Dohin E; Pouchot J; INSERM U292, Kremlin Bicetre, France.; Assessment of the quality of life (QoL) of human immunodeficiency virus (HIV)-infected subjects is often based on questionnaires in which the items or questions are not seen to be relevant by patients, nor by the users of the data obtained. It therefore seemed appropriate to return to the issue. The methodological and
Health status assessment for the twenty-first century: item response theory, item banking and computer adaptive testing.: Qual Life Res. 1997 Aug;6(6):595-600. Unique Identifier : AIDSLINE /MED97471617; Revicki DA; Cella DF; MEDTAP International, Bethesda, MD 20814, USA.; Health status assessment is frequently used to evaluate the combined impact of human immunodeficiency virus (HIV) disease and its treatment on functioning and well-being from the patient s perspective. No single health status measure can efficiently cover the range of problems in functioning and well-being experienced
Summary and recommendations for future research.: Qual Life Res. 1997 Aug;6(6):601-5. Unique Identifier : AIDSLINE /MED97471618; Berzon RA; Leplege AP; Lohr KN; Lenderking WR; Wu AW; Bayer Pharmaceutical Division, West Haven, CT, USA.
Learning disturbances in offsprings of zidovudine (AZT) treated rats.: Neurobiology (Bp). 1997;5(1):83-5. Unique Identifier : AIDSLINE /MED97448295; Petyko Z; Lenad L; Sumegi B; Hajnal A; Csete B; Faludi B; Jando G; Neurophysiology Research Group, Hungarian Academy of Sciences, Pecs,; Hungary.
AIDS drugs. Dramatic twist on coverage.: Hosp Health Netw. 1997 Oct 5;71(19):82, 84. Unique Identifier : AIDSLINE /MED98004031; Nordhaus-Bike AM
Breastfeeding and HIV transmission [news]: Midwifery Today Childbirth Educ. 1997 Fall;(43):69. Unique Identifier : AIDSLINE /MED98017915
Eukaryotic initiation factor 5A activity and HIV-1 Rev function.: Biol Signals. 1997 May-Jun;6(3):124-33. Unique Identifier : AIDSLINE /MED97430996; Bevec D; Hauber J; Novartis Research Institute, Department of Immunodermatology, Vienna,; Austria.; Eukaryotic initiation factor 5A (eIF-5A) is the only cellular protein known to contain the unusual amino acid hypusine, a modification that appears to be required for cell proliferation. This hypusine-modified protein stimulates synthesis of methionyl-puromycin in an in vitro assay which mimics the formation of the fi
Two distinct pathways for intronless mRNA expression: one related, the other unrelated to human immunodeficiency virus Rev and human T cell leukemia virus type I Rex functions.: Biol Signals. 1997 May-Jun;6(3):134-42. Unique Identifier : AIDSLINE /MED97430997; Kiyokawa T; Umemoto T; Watanabe Y; Matsushita S; Shida H; Institute for Virus Research, Kyoto University, Japan.; Intronless mRNAs were classified into two classes based on the sensitivities of their expression to the inhibitory effect of TAgRex, a dominant-negative mutant of the Rex protein of human T cell leukemia virus type I, and their abilities to express the genes encoded in the intron of the human immunodeficiency virus HI
Effects of inhibitors of RNA and protein synthesis on the subcellular distribution of the eukaryotic translation initiation factor, eIF-5A, and the HIV-1 Rev protein.: Biol Signals. 1997 May-Jun;6(3):143-9. Unique Identifier : AIDSLINE /MED97430998; Shi XP; Yin KC; Waxman L; Department of Biological Chemistry, Merck Research Laboratories, West; Point, Pa 19486, USA. xiao-ping-shi@merck.com; The subcellular distributions of the endogenous eukaryotic translation initiation factor, eIF-5A, and Rev, a protein of the human immunodeficiency virus proposed to interact with eIF-5A, were studied in COS-7 cells treated with inhibitors of RNA or protein synthesis. We have previously shown that transiently expressed
Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification.: Biol Signals. 1997 May-Jun;6(3):166-74. Unique Identifier : AIDSLINE /MED97431001; Liu YP; Nemeroff M; Yan YP; Chen KY; Department of Chemistry, Rutgers-State University of New Jersey; 08855-0939, USA.; Hypusine formation on the eukaryotic initiation factor 5A eIF-5A) precursor represents a unique posttranslational modification that is ubiquitously present in eukaryotic cells and archaebacteria. Specific inhibition of deoxyhypusine synthase leads to growth arrest and cell death. The precise cellular function of eIF-5
HIV transmission in men who have sex with men.: Commun Dis Rep CDR Wkly. 1993 Feb 19;3(8):33. Unique Identifier : AIDSLINE /MED98017325
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1993 Feb 19;3(8):37-8. Unique Identifier : AIDSLINE /MED98017326
Evaluation of awareness and utilization of an autologous blood transfusion programme.: Transfus Med. 1997 Sep;7(3):197-202. Unique Identifier : AIDSLINE /MED97461944; Dhingra-Kumar N; Sikka M; Madan N; Sood SK; Department of Pathology, University College of Medical Sciences,; Delhi, India.; Autologous blood transfusion (ABT) has an important role in transfusion practice in the developing world due to increasing incidence of HIV and hepatitis C virus infection. Our study was done to evaluate the level of awareness and utilization of an autologous blood transfusion programme in a teaching hospital in Delhi
Spontaneous eye blinking, a measure of dopaminergic function, in children with acquired immunodeficiency syndrome.: Arch Pediatr Adolesc Med. 1997 Oct;151(10):1025-32. Unique Identifier : AIDSLINE /MED98002530; Vreugdenhil H; Brouwers P; Wolters P; Bakker D; Moss H; HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda,; Md., USA.; OBJECTIVE: To investigate possible alterations in dopaminergic function in children with acquired immunodeficiency syndrome by evaluating spontaneous eye blink rate, a putative measure of central dopaminergic function. DESIGN: Evaluation of previously videotaped test sessions of a consecutive case series of 50 childre
Informing children of their human immunodeficiency virus infection [editorial; comment]: Arch Pediatr Adolesc Med. 1997 Oct;151(10):976-7. Unique Identifier : AIDSLINE /MED98002521; Schonfeld DJ
Patterns of disclosure and perceptions of the human immunodeficiency virus in infected elementary school-age children [see comments]: Arch Pediatr Adolesc Med. 1997 Oct;151(10):978-85. Unique Identifier : AIDSLINE /MED98002522; Funck-Brentano I; Costagliola D; Seibel N; Straub E; Tardieu M; Blanche S; Unite d'Immuno-Hematologie, Federation de Pediatrie, Hopital; Necker-Enfants Malades, Paris, France.; OBJECTIVE: To investigate the patterns of disclosure and perceptions of human immunodeficiency virus (HIV) status in a group of HIV-infected elementary school-age children. DESIGN: A survey. SETTING: A referred care university hospital center. PATIENTS: All HIV-infected children born before August 31, 1985, and schedu
Inclusion body myositis and myopathies.: Curr Opin Neurol. 1997 Oct;10(5):413-20. Unique Identifier : AIDSLINE /MED97471947; Sivakumar K; Dalakas MC; Neuromuscular Diseases Section, National Institute of Neurological; Disorders and Stroke, National Institutes of Health, Bethesda,; Maryland 20892-1382, USA.; Sporadic inclusion body myositis is a frequent, acquired, adult-onset vacuolar myopathy affecting proximal and distal muscles with a distinct, easily identifiable clinical pattern. Although its primary cause is still unknown, autoimmune, viral, and degenerative processes, alone or in combination, are being considered.
Community equipoise and the architecture of clinical research.: Camb Q Healthc Ethics. 1997 Fall;6(4):385-96. Unique Identifier : AIDSLINE /MED97437683; Karlawish JH; Lantos J; Section of General Internal Medicine, University of Chicago, USA.; We have argued for a revision of Freedman s concept of clinical equipoise to a broader sense of community that includes physicians and patients. Community equipoise is an essential condition for physicians and patients to answer these questions: Should there be a trial? If so, what kind? We have argued that community
[Ethical dilemmas of nurses concerning informational privacy of persons with HIV/AIDS. An exploratory study of the kinds of dilemmas, emotional experiences and coping strategies]: Verpleegkunde. 1997 May;12(2):82-94. Unique Identifier : AIDSLINE /MED98018168; Vrehen HM; van der Bijl J; Divisie Interne Geneeskunde en Dermatologie van het Academisch; Ziekenhuis Utrecht.; This paper reports on the results of a study conducted in 1994. The aim of the study was to gain insight into nurses perceptions of ethical dilemmas concerning informational privacy of patients with hiv/aids. The chosen research method was descriptive, from a qualitative research perspective (Grounded Theory). The pu
Nonspecific interstitial pneumonitis mimicking Pneumocystis carinii pneumonia.: Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):912-7. Unique Identifier : AIDSLINE /MED97455792; Sattler F; Nichols L; Hirano L; Hiti A; Hofman F; Hughlett C; Zeng L; Boylen CT; Koss M; Department of Medicine, University of Southern California School of; Medicine, Los Angeles County-University of Southern California Medical; Center 90033, USA.; Bronchoalveolar lavage (BAL) and transbronchial biopsies from 351 human immunodeficiency virus (HIV)-positive patients with presumed Pneumocystis pneumonia were analyzed to determine the spectrum and frequency of interstitial lung disease mimicking Pneumocystis pneumonia. Among 67 patients without Pneumocystis, nonspe
Comparison of murine nasal-associated lymphoid tissue and Peyer's patches.: Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1256-62. Unique Identifier : AIDSLINE /MED98011995; Heritage PL; Underdown BJ; Arsenault AL; Snider DP; McDermott MR; Department of Pathology, McMaster University, Hamilton, Ontario,; Canada.; The nasal mucosal is the first site of contact with inhaled antigens. However, the nature of local immune responses and the role of nasal-associated lymphoid tissue (NALT) in those responses have rarely been studied. To characterize the cells involved in mucosally derived immune responses, NALT and Peyer s patch (PP)
Ribavirin therapy for adenovirus pneumonia in an AIDS patient.: Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1263-4. Unique Identifier : AIDSLINE /MED98011996; Maslo C; Girard PM; Urban T; Guessant S; Rozenbaum W; Service des Maladies Infectieuses et Tropicales, Hopital Rothschild,; Paris, France.; We report the effectiveness of ribavirin in an AIDS patient with multinodular pneumonia due to adenovirus. A 38-year-old AIDS patient who experienced multiple opportunistic infections and whose CD4 lymphocyte count was 5/mm3 developed bilateral nodular lung opacities. Lung surgical biopsy yielded necrotizing pneumonit
Chest radiographic findings in patients with tuberculosis with recent or remote infection.: Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1270-3. Unique Identifier : AIDSLINE /MED98011998; Jones BE; Ryu R; Yang Z; Cave MD; Pogoda JM; Otaya M; Barnes PF; Department of Radiology, University of Southern California School of; Medicine, Los Angeles, USA.; To determine if chest radiographic findings differ in adult tuberculosis patients with recent and remote infection, we reviewed the chest radiographs of 103 patients with tuberculosis in Los Angeles and performed RFLP analyses of their Mycobacterium tuberculosis isolates. Patients whose isolates had identical or close
The genetics of allergen-induced airway hyperresponsiveness in mice.: Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 2):S89-96. Unique Identifier : AIDSLINE /MED98011951; Wills-Karp M; Ewart SL; Department of Environmental Health Sciences, The Johns Hopkins; University School of Hygiene and Public Health, Baltimore, Maryland; 21205, USA.; Airway hyperresponsiveness (AHR) is a fundamental aspect of asthma that has been shown to be influenced by both environmental and genetic factors. Antigen sensitization and challenge of the A/J inbred mouse strain induced AHR, eosinophilic airway inflammation, and lung goblet cell hyperplasia. We discuss the evidence
Patients unaware of their HIV status present to inner city accident and emergency department with respiratory complications.: J Accid Emerg Med. 1997 Sep;14(5):304-6. Unique Identifier : AIDSLINE /MED97461656; Landau R; Coker R; Vermeulen E; Touquet R; Fothergill J; Poznansky MC; Department of Accident and Emergency Medicine, St Mary's Hospital,; London W2 1NY, UK.; OBJECTIVE: To examine the clinical presentations and management of patients presenting to an accident and emergency (A&E) department with an AIDS defining illness (ADI). METHODS: Presentations of patients in the A&E department with ADI were reviewed retrospectively. The age, sex, ethnic origin, risk factor for
MR spectroscopy and diffusion-weighted MR imaging in focal brain lesions in AIDS.: Neuroimaging Clin N Am. 1997 Aug;7(3):409-26. Unique Identifier : AIDSLINE /MED98021586; Chang L; Ernst T; Department of Neurology, University of California, Los Angeles, School; of Medicine, USA.; Focal brain lesions in AIDS may be difficult to diagnose with conventional imaging techniques. Recent advances in magnetic resonance (MR), including MR spectroscopy (MRS) and diffusion-weighted imaging (DWI), may provide additional information in the evaluation of these diseases. MRS of various AIDS brain lesions show
Functional imaging of the AIDS dementia complex and the metabolic pathology of the HIV-1-infected brain.: Neuroimaging Clin N Am. 1997 Aug;7(3):431-45. Unique Identifier : AIDSLINE /MED98021587; Navia BA; Gonzalez RG; Department of Neurology, Tufts University School of Medicine, Boston,; Massachusetts, USA.; The AIDS- dementia complex remains one of the more common neurologic disorders associated with human immunodeficiency virus HIV) infection. Despite several advances that have been made in elucidating some of its clinical and biological features, pathogenesis is not well understood,
Magnetization transfer imaging in AIDS-related brain diseases.: Neuroimaging Clin N Am. 1997 Aug;7(3):447-60. Unique Identifier : AIDSLINE /MED98021588; Dousset V; Armand JP; Huot P; Viaud B; Caille JM; Service de Neuroradiologie, Hopital Pellegrin, Bordeaux, France.; MT makes it possible to characterize tissue destruction in several CNS diseases, including AIDS-related diseases such as PML or HIV encephalitis. MR may be helpful in establishing diagnosis, disease burden, prognosis, and therapeutic efficacy. MT may also contribute to the investigation of the natural history of the d
Rationale for the use of contrast media in MR imaging.: Neuroimaging Clin N Am. 1997 Aug;7(3):461-98. Unique Identifier : AIDSLINE /MED98021589; Andreula CF; Recchia-Luciani AN; Neuroradiology Service, University of Bari, Italy.; Understanding the rationale of contrast media use in MR imaging is based on knowledge of the blood brain barrier (BBB) and the pathophysiology of infectious agents attacking the central nervous system. This article focuses on the relationship between BBB structures and functions in healthy and unhealthy conditions and
Nuclear medicine applications to the neuroimaging of AIDS. A neuroradiologist's perspective.: Neuroimaging Clin N Am. 1997 Aug;7(3):499-511. Unique Identifier : AIDSLINE /MED98021590; Ruiz A; Post JD; Ganz WI; Georgiou M; Department of Radiology, University of Miami School of Medicine,; Florida, USA.; The human immunodeficiency virus (HIV) responsible for AIDS is reaching epidemic proportions in the United States and Europe. As new therapeutic modalities against HIV are uncovered and applied to treat prophylactically asymptomatic and therapeutically symptomatic HIV positive patients
Central nervous system opportunistic infections.: Neuroimaging Clin N Am. 1997 Aug;7(3):513-25. Unique Identifier : AIDSLINE /MED98021591; Wright D; Schneider A; Berger JR; Department of Neurology, University of Kentucky College of Medicine,; Lexington, USA.; The spectrum of opportunistic infections occurring in association with human-immunodeficiency virus, type 1, is very broad. These infections develop most frequently in the setting of advanced immunosuppression. There is no part of the neuraxis that is immune to these complications and the concurrence of more than one
HIV-1-related neurologic disorders. Neurosurgical implications.: Neuroimaging Clin N Am. 1997 Aug;7(3):527-59. Unique Identifier : AIDSLINE /MED98021592; Levy RM; Rothholtz V; Division of Neurological Surgery, Northwestern University Medical; School, Chicago, Illinois, USA.; It has become important for clinicians to increase their understanding of the breadth, mechanism, and neurosurgical implications of viral illnesses of the central nervous system. These needs can now be more safely and accurately addressed using stereotactic neurosurgical techniques. This article provides an introducti
Subtle neuropsychological impairment and minor cognitive-motor disorder in HIV-1 infection. Neuroradiological, neurophysiological, neuroimmunological, and virological correlates.: Neuroimaging Clin N Am. 1997 Aug;7(3):561-79. Unique Identifier : AIDSLINE /MED98021593; Goodkin K; Wilkie FL; Concha M; Asthana D; Shapshak P; Douyon R; Fujimura RK; LoPiccolo C; University of Miami School of Medicine, Florida, USA.; HIV-1 infection of brain may be associated with multiple treatment targets, only the most severe of which is represented by HAD. Focusing on earlier treatment targets such as MCMD and cognitive-motor impairment in the absence of any clinical disorder (as well as neuroprotection) may prove to be of greater clinical uti
Clinical and biologic features of the AIDS dementia complex.: Neuroimaging Clin N Am. 1997 Aug;7(3):581-92. Unique Identifier : AIDSLINE /MED98021594; Navia BA; Department of Neurology, Tufts University School of Medicine, Boston,; Massachusetts, USA.; Human immunodeficiency virus type 1 infection is frequently associated with complications of the nervous system, involving all levels of the neuraxis. Many of these represent focal disorders, such as toxoplasmosis, lymphoma, and progressive multifocal leukoencephalopathy. This article reviews the salient clinical and
Pediatric neuro-AIDS. Update.: Neuroimaging Clin N Am. 1997 Aug;7(3):593-613. Unique Identifier : AIDSLINE /MED98021595; Belman AL; Department of Neurology and Pediatrics, School of Medicine, State; University of New York at Stony Brook, USA.; Vertically transmitted HIV-1 infection occurs in an immature developing organism. The maturational stage of the nervous and immune system when exposed to the direct or indirect effects of the virus is likely to be of utmost importance. Innumerable dynamic interactions occur between these two systems during development
Neuroimaging--autopsy correlations in AIDS.: Neuroimaging Clin N Am. 1997 Aug;7(3):615-37. Unique Identifier : AIDSLINE /MED98021596; Smirniotopoulos JG; Koeller KK; Nelson AM; Murphy FM; Department of Radiology and Nuclear Medicine, Uniformed Services,; University of the Health Sciences, School of Medicine, Bethesda,; Maryland, USA.; This article is a brief review of the radiologic-pathologic correlation of central nervous lesions occurring in patients with AIDS. The major discussions of the imaging appearance and radiologic differential diagnosis have been presented elsewhere in this issue. Our emphasis is on the gross pathologic correlations tha
Neuropathology of myelitis, myelopathy, and spinal infections in AIDS.: Neuroimaging Clin N Am. 1997 Aug;7(3):639-50. Unique Identifier : AIDSLINE /MED98021597; Budka H; Clinical Department of Neuropathology and Neurochemistry, University; of Vienna, Austria.; In AIDS, pathology in the spinal contents usually follows that in the brain but is less frequent. Opportunistic infections are found in an average of 9.5% of spinal AIDS autopsies but in 54% of autopsies of the whole CNS. Necrotizing CMV radiculomyelitis is a ra
Haemophilus influenzae septic arthritis and HIV disease [letter]: Br J Rheumatol. 1997 Sep;36(9):1027. Unique Identifier : AIDSLINE /MED98018733; Manfredi R; Legnani G; Mastroianni A; Coronado OV; Chiodo F
The sequential analysis of T lymphocyte subsets and interleukin-6 in polymyalgia rheumatica patients as predictors of disease remission and steroid withdrawal.: Br J Rheumatol. 1997 Sep;36(9):976-80. Unique Identifier : AIDSLINE /MED98018719; Corrigall VM; Dolan AL; Dasgupta B; Panayi GS; Rheumatology Unit, Guy's Hospital, London.; CD4 and CD8 T lymphocyte subsets, the late T cell activation marker, HLA-DR, and serum interleukin-6 (IL-6) levels of 57 polymyalgia rheumatica (PMR) patients were followed over 2 yr to investigate whether they could be used to predict the safe withdrawal of steroid therapy. Cell phenotypes were studied by flow cytome
In vitro antimicrobial properties of azidothymidine (AZT).: Acta Microbiol Immunol Hung. 1997;44(2):165-71. Unique Identifier : AIDSLINE /MED97471724; Monno R; Marcuccio L; Valenza MA; Leone E; Bitetto C; Larocca A; Maggi P; Quarto M; Institute of Medical Microbiology, Clinic of Infectious Diseases and; Institute of Hygiene, University of Bari, Bari, Italy.; In addition to the activity against a number of retroviruses, azidothymidine ( AZT ) has antibacterial activity against many bacteria. The effect of AZT on 224 bacterial species, including 25 strains of Salmonella spp. isolated from HIV-positive patient
[New options in the management of HIV-infection]: Fortschr Med Suppl. 1997;180:1-8. Unique Identifier : AIDSLINE /MED97473144
Dipeptidyl peptidase IV (CD26) activity in human alloreactive T cell subsets varies with the stage of differentiation and activation status.: Transpl Immunol. 1997 Jun;5(2):152-61. Unique Identifier : AIDSLINE /MED97414177; Ruiz P; Hao L; Zucker K; Zacharievich N; Viciana AL; Shenkin M; Miller J; Department of Pathology, University of Miami School of Medicine,; Florida 33101, USA.; Dipeptidyl peptidase IV (DPP IV), also known as CD26, is a transmembrane serine aminopeptidase which has an ontogenically related expression on T cells and participates on several immunological functions. CD26 appears to play an important role in alloimmunity during host T cell activation subsequent to alloantigen enc
A strategy for generating consistent long-term donor-specific tolerance to solid organ allografts.: Transpl Immunol. 1997 Jun;5(2):83-8. Unique Identifier : AIDSLINE /MED97414168; Levy AE; Alexander JW; Babcock GF; University of Cincinnati, Medical Center, Department of Surgery,; Cincinnati, OH 45267-0558, USA.; Current triple drug immunosuppression while effective, increases the risk of opportunistic infection and lymphoproliferative disorders. An alternative strategy would be the generation of donor-specific tolerance with short-term treatment. The use of donor-specific transfusions (DST) with a single brief course of cyclo
The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease.: Bioorg Med Chem. 1997 Jul;5(7):1311-20. Unique Identifier : AIDSLINE /MED98020698; Rutenber EE; De Voss JJ; Hoffman L; Stroud RM; Lee KH; Alvarez J; McPhee F; Craik C; Ortiz de Montellano PR; Department of Biochemistry and Biophysics, University of California at; San Francisco, 94143, U.S.A.; A pharmacophore derived from the structure of the dithiolane derivative of haloperidol bound in the active site of the HIV-1 protease (HIV-1 PR) has been used to search a three-dimensional database for new inhibitory frameworks. This search identified an FMOC-protected N-tosyl arginine as a lead candidate. A derivativ
Transmission of HIV from mother to child.: Paediatr Nurs. 1997 Sep;9(7):18-20. Unique Identifier : AIDSLINE /MED98009673; Durston P; Birmingham children's hospital NHS Trust.
Activation of latent HIV-1 by Mycobacterium tuberculosis and its purified protein derivative in alveolar macrophages from HIV-infected individuals in vitro.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):325-31. Unique Identifier : AIDSLINE /MED98000298; Toossi Z; Nicolacakis K; Xia L; Ferrari NA; Rich EA; Case Western Reserve University, Cleveland Veterans Affairs, Ohio; 44106-4984, U.S.A.; Although Mycobacterium tuberculosis (MTB) and its purified protein derivative (PPD) induce HIV in cell lines that harbor latent HIV infection, it is not known whether similar activation of HIV in primary macrophages infected with HIV occurs. This possibility was examined using alveolar macrophages (AM) obtained by bro
Progressive encephalopathy associated with CD4/CD8 inversion in adult FIV-infected cats.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):332-40. Unique Identifier : AIDSLINE /MED98000299; Podell M; Hayes K; Oglesbee M; Mathes L; Department of Veterinary Clinical Sciences, Center for Retrovirus; Research, The Ohio State University, Columbus 43210, U.S.A.; Experimental intravenous challenge of five adult cats with the feline immunodeficiency virus Maryland isolate (FIV-MD) was investigated for its ability to induce neurologic abnormalities associated with the onset of immunodeficiency. Five 8-month-old cats were inoculated with 1000 median tissue culture infective dose
Clinical manifestations and predictors of survival in older women infected with HIV.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):341-5. Unique Identifier : AIDSLINE /MED98000300; Clark RA; Bessinger R; Louisiana State University Medical Center, New Orleans, U.S.A.; To review the natural history of HIV infection in older women, a retrospective review of women enrolled in the HIV Outpatient Program based at the Medical Center of Louisiana in New Orleans was performed. Eighty-four of the women were at least 40 years of age. Older women were more likely to be diagnosed with selected
Predictors of survival in HIV-infected persons with 50 or fewer CD4 cells/mm3.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):346-55. Unique Identifier : AIDSLINE /MED98000301; Spino C; Kahn JO; Dolin R; Phair JP; Statistical and Data Analysis Center, Harvard School of Public Health,; Boston, Massachusetts, U.S.A.; The objective of this study was to identify prognostic factors for survival in patients with pretreatment CD4
Application of an expert system in the management of HIV-infected patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):356-62. Unique Identifier : AIDSLINE /MED98000302; Pazzani MJ; See D; Schroeder E; Tilles J; Department of Information and Computer Sciences, University of; California, Irvine, Orange 92868, U.S.A.; A rule-based expert system, Customized Treatment Strategies for HIV (CTSHIV), which encodes information from the literature on known drug-resistant mutations was developed. Additional rules include ranking and weighting based on antiviral activities, redundant mechanisms of action, overlapping toxicities, relative lev
Survival after AIDS diagnosis in a cohort of hemophilia patients. Multicenter Hemophilia Cohort Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):363-9. Unique Identifier : AIDSLINE /MED98000303; Gail MH; Tan WY; Pee D; Goedert JJ; Biostatistics Branch, National Cancer Institute, Bethesda, Maryland; 20892-7368, U.S.A.; We studied factors affecting survival after the diagnosis of AIDS in a cohort of 1253 patients with hemophilia. The nature of the AIDS-defining condition was found to be as important as age at seroconversion and CD4+ lymphocyte level in predicting survival. A multivariate analysis yielded estimates of median survival
High risk of HIV-related mortality is associated with selenium deficiency.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):370-4. Unique Identifier : AIDSLINE /MED98000304; Baum MK; Shor-Posner G; Lai S; Zhang G; Lai H; Fletcher MA; Sauberlich H; Page JB; Department of Psychiatry and Behavioral Sciences, University of Miami,; School of Medicine, Florida 33136, U.S.A.; To determine the independent contribution of specific immunologic and nutritional factors on survival in HIV-1 disease, CD4 cell count, antiretroviral treatment, plasma levels of vitamins A, E, B6, and B12 and minerals selenium and zinc were considered in relation to relative risk for HIV-related mortality. Immune par
HIV-1 risk and vaccine acceptability in the Ugandan military.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):375-80. Unique Identifier : AIDSLINE /MED98000305; Hom DL; Johnson JL; Mugyenyi P; Byaruhanga R; Kityo C; Louglin A; Svilar GM; Vjecha M; Mugerwa RD; Ellner JJ; Department of Medicine, Case Western Reserve University and University; Hospitals of Cleveland, Ohio 44106-4984, U.S.A. dlh3@po.cwru.edu; Between July and October 1993, 570 19- to 22-year-old volunteers were screened for HIV-1, with a resulting seroprevalence rate of 18.3% (95% CI: 14.0%, 22.6%). A cohort of 249 HIV-1-noninfected military recruits in the Ugandan Peoples Defense Forces was followed prospectively for up to 18 months to document rates of
Prevalence and risk factors for HTLV-II infection in 913 injecting drug users in Stockholm, 1994.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):381-6. Unique Identifier : AIDSLINE /MED98000306; Krook A; Albert J; Andersson S; Biberfeld G; Blomberg J; Eklund I; Engstrom A; Julander I; Kall K; Martin C; Stendahl P; Struve J; Sonnerborg A; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institute, Huddinge University Hospital,; Stockholm, Sweden.; The prevalence and risk factors for acquisition of human T-cell lymphotropic virus type I and II (HTLV-I and II) were investigated in a prospective study of 913 injecting drug users IDUs) in Stockholm in 1994. Epidemiologic data were recorded, and blood samples were tested for antibodies against HTLV-I and HTLV-II; hu
Decreased survival of HTLV-I carriers in leprosy patients from the Democratic Republic of the Congo: a historical prospective study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):387-90. Unique Identifier : AIDSLINE /MED98000307; Lechat MF; Shrager DI; Declercq E; Bertrand F; Blattner WA; Blumberg BS; Universite Catholique de Louvain, Brussels, Belgium.; In this historical prospective study using sera stored for 22 years, we investigated the effect of HTLV-I infection on survival in a population of leprosy patients in the Democratic Republic of the Congo (formerly Zaire ). We also determined th
Modified amplicor HIV-1 polymerase chain reaction assay in Thailand [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):391-2. Unique Identifier : AIDSLINE /MED98000308; Young N; Shaffer N; Chaowanachan T; Rapier J; Kittinunvorakoon C; Suksaweang S; Rayfield M; Kalish ML; Mastro TD
Thalidomide use is associated with weight gain in HIV-1-positive clients [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):392. Unique Identifier : AIDSLINE /MED98000309; Sharp M; Getty J; Klausner JD
HIV-1 encodes a sequence overlapping env gp41 with highly significant similarity to selenium-dependent glutathione peroxidases [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):393-4. Unique Identifier : AIDSLINE /MED98000310; Taylor EW; Bhat A; Nadimpalli RG; Zhang W; Kececioglu J
HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):1-9. Unique Identifier : AIDSLINE /MED98018764; Mavoungou E; Georges-Courbot MC; Poaty-Mavoungou V; Nguyen HT; Yaba P; Delicat A; Georges AJ; Russo-Marie F; Department of Immunology and Immunogenetics, International Center for; Medical Research, Franceville, Gabon. emavoung@cirmfrv.fr; We investigated the early interactions between HIV-1, HIV-2, and simian immunodeficiency virus (SIV) envelope glycoproteins gp120(IIIB), gp105(ROD), and gp120(mac251), and human and macaque cells of the lymphocytic series. Our results demonstrate that the soluble viral glycoproteins induce a specific phospholipase A2
HIV-infected individuals with the CCR delta32/CCR5 genotype have lower HIV RNA levels and higher CD4 cell counts in the early years of the infection than do patients with the wild type. Copenhagen AIDS Cohort Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):10-4. Unique Identifier : AIDSLINE /MED98018765; Katzenstein TL; Eugen-Olsen J; Hofmann B; Benfield T; Pedersen C; Iversen AK; Sorensen AM; Garred P; Koppelhus U; Svejgaard A; Gerstoft J; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.; The relations among serum HIV RNA levels, CD4 cell counts, presence of the mutant CCR5-allele in heterozygous form, and clinical outcome was analyzed in 96 patients from the Copenhagen AIDS Cohort. In the early years of the infection, patients with the CCR5 delta32/CCR5 genotype had significantly lower HIV RNA levels
Cost-utility analysis of prophylactic treatment with oral ganciclovir for cytomegalovirus retinitis.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):15-21. Unique Identifier : AIDSLINE /MED98018766; Moore RD; Chaisson RE; Johns Hopkins University School of Medicine, Baltimore, Maryland; 21205, U.S.A.; OBJECTIVE: Cytomegalovirus ( CMV ) retinitis is a relatively common opportunistic infection in late-stage HIV disease, causing significant morbidity and mortality. Prophylactic use of oral ganciclovir has recently been shown to decrease the incidence of CMV retini
Predictors and impact of patients lost to follow-up in a long-term randomized trial of immediate versus deferred antiretroviral treatment.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):22-30. Unique Identifier : AIDSLINE /MED98018767; Ioannidis JP; Bassett R; Hughes MD; Volberding PA; Sacks HS; Lau J; Division of Geographic Medicine and Infectious Diseases, New England; Medical Center, Boston, Massachusetts, U.S.A.; We studied predictors for losses to follow-up and the impact of such losses in the AIDS Clinical Trials Group 019 protocol, a long-term randomized trial of immediate versus deferred antiretroviral therapy in asymptomatic HIV-1-infected patients with >500 CD4 cells/mm3. The trial was selected because of its key importa
HIV-2 genetic variation and DNA load in asymptomatic carriers and AIDS cases in Guinea-Bissau.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):31-8. Unique Identifier : AIDSLINE /MED98018768; Norrgren H; Marquina S; Leitner T; Aaby P; Melbye M; Poulsen AG; Larsen O; Dias F; Escanilla D; Andersson S; Albert J; Naucler A; National Public Health Laboratory, Bissau, Guinea-Bissau.; The purpose of this study was to document which genetic subtypes of HIV-2 are present in Guinea-Bissau and to investigate whether asymptomatic HIV-2 carriers and AIDS patients carry distinct genetic variants. A secondary aim was to correlate proviral DNA load to clinical and immun
Trends in incidence of AIDS illnesses in Australia from 1983 to 1994: the Australian AIDS cohort.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):39-43. Unique Identifier : AIDSLINE /MED98018769; Dore GJ; Hoy JF; Mallal SA; Li Y; Mijch AM; French MA; Cooper DA; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research, University; of New South Wales, Sydney, Australia.; To assess time trends in incidence of AIDS illnesses in Australia , a retrospective cohort of people diagnosed with AIDS from January 1, 1983 to December 31, 1994 in three HIV medicine units in Sydney, Melbourne, and Perth was established. Data on initial and subsequent AIDS illn
Co-occurrence of AIDS and tuberculosis: results of a database match" and investigation.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):44-9. Unique Identifier : AIDSLINE /MED98018770; Gollub EL; Trino R; Salmon M; Moore L; Dean JL; Davidson BL; AIDS Activities Coordinating Office and the TB Control Division,; Department of Public Health, Philadelphia, Pennsylvania 19146, U.S.A.; PURPOSE: To conduct a match between the AIDS and Tuberculosis TB) Registries in Philadelphia. METHODS: Database extracts for the year 1993 were prepared manually and matched by name, birth date, and social security number. Reported cases not matching with those on the primary registry were investigated. Proportion lev
Increasing HIV prevalence in a rural district of South Africa from 1992 through 1995.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):50-3. Unique Identifier : AIDSLINE /MED98018771; Coleman RL; Wilkinson D; Hlabisa Hospital, South African Medical Research Council.; OBJECTIVES: To describe the increasing prevalence of HIV infection in a rural district in South Africa , to compare this with a nearby urban setting, and to estimate the prevalence of infection in the general population of the rural district. DESIGN: Serial anonymous cross-sectiona
Updates of cost of illness and quality of life estimates for use in economic evaluations of HIV prevention programs.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):54-62. Unique Identifier : AIDSLINE /MED98018772; Holtgrave DR; Pinkerton SD; Center for AIDS Intervention Research, Medical College of Wisconsin,; Milwaukee 53202, U.S.A. holtgrav@post.its.mcw.edu; To allocate limited economic and other resources for HIV prevention and treatment for maximum benefit, health policy planners and decision makers require accurate, current estimates of the lifetime costs of HIV-related illness and the impact of therapy on the quality of life of HIV-infected persons. These data are cen
HIV-1 subtypes in Nairobi, Kenya [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):63-4. Unique Identifier : AIDSLINE /MED98018773; Belda FJ; Mwchari C; Hawken M; Barlow KL; Clewley JP
CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation.: J Mol Med. 1997 Aug;75(8):603-8. Unique Identifier : AIDSLINE /MED97442661; Samoilova EB; Horton JL; Zhang H; Chen Y; Institute for Human Gene Therapy, University of Pennsylvania School of; Medicine, Philadelphia 19104, USA.; Although it is well established that CD40 and its ligand (CD40L) play pivotal roles in the development of humoral immunity, their roles in cell-mediated immunity and cell-mediated autoimmune diseases are not well defined. We report here that CD40:CD40L interaction is crucial for the development of experimental autoimm
Reduction in risk behavior among adults with severe mental illness who learned to advocate for HIV prevention.: Psychiatr Serv. 1997 Oct;48(10):1283-8. Unique Identifier : AIDSLINE /MED97465039; Kelly JA; McAuliffe TL; Sikkema KJ; Murphy DA; Somlai AM; Mulry G; Miller JG; Stevenson LY; Fernandez MI; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee 53226, USA.; OBJECTIVES: The study evaluated the relative impact of HIV risk reduction interventions for adults with severe mental illness living in the inner city. METHODS: A total of 104 chronically mentally ill men and women were interviewed to determine sexual risk behavior over the past month and to assess HIV risk-related ps
Antiviral ribozymes. New jobs for ancient molecules.: Mol Biotechnol. 1997 Aug;8(1):17-33. Unique Identifier : AIDSLINE /MED97468308; Menke A; Hobom G; Institut fur Mikrobiologie und Molekularbiologie, Giessen, Germany.; Catalytic RNAs are a genetic property not only of some particular viroids or viruses, but also are more common naturally among eukaryotes and even prokaryotes than earlier expected. However, the major interest in ribozymes results from their potential for development of tailor-made cDNA constructions designed to be
[Adult T-cell leukemia]: Ryoikibetsu Shokogun Shirizu. 1997;(17 Pt 2):333-6. Unique Identifier : AIDSLINE /MED97423989; Nakayama M; Tajiri M; Shimomura T; Tazoe N; Kumamoto Kurokami Clinic.
[HIV associated nephropathy]: Ryoikibetsu Shokogun Shirizu. 1997;(17 Pt 2):507-10. Unique Identifier : AIDSLINE /MED97424037; Harada T; Ozono Y; Miyazaki M; Renal Care Unit, Nagasaki University Hospital.
[Infection of mycoplasma]: Ryoikibetsu Shokogun Shirizu. 1997;(17 Pt 2):694-6. Unique Identifier : AIDSLINE /MED97424087; Sakuma S; Sakumoto M; Kumazawa J; Department of Urology, Faculty of Medicine, Kyushu University.
Cell and molecular biology of chemical allergy.: Clin Rev Allergy Immunol. 1997 Summer;15(2):145-68. Unique Identifier : AIDSLINE /MED97461042; Kimber I; Dearman RJ; Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield,; Cheshire, UK.
Reactivation of oral herpes simplex virus: implications for clinical management of herpes simplex virus recurrence during radiotherapy.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Sep;84(3):272-8. Unique Identifier : AIDSLINE /MED98020979; Oakley C; Epstein JB; Sherlock CH; Department of Oral Biological and Medical Sciences, Faculty of; Dentistry, University of British Columbia, Canada.; Herpes viruses are characterized by their ability to establish and maintain latent infections that can be reactivated. Several stimuli can trigger the reactivation of herpes viruses, which are perhaps best recognized in the recurrent blisters and ulcers associated with herpes simplex virus. We present two clinical cas
The dangerous financial politics of AIDS "cocktail" therapies.: J Health Care Finance. 1997 Fall;24(1):59-63. Unique Identifier : AIDSLINE /MED97468245; Wolfson J; Tampa Bay Pediatric and Family AIDS Program, University of South; Florida College of Public Health, Tampa, USA.; Political pressures by local AIDS activists are forcing some communities to redirect limited financial resources exclusively toward new drug therapies called protease inhibitors . These expensive and often reckless decisions threaten both the financial integrity of A
AIDS buyers' clubs.: Am J Health Syst Pharm. 1997 Sep 15;54(18):2122-4. Unique Identifier : AIDSLINE /MED98021014; DeChristoforo R; Minor JR; Pharmacy Department, Warren G. Magnuson Clinical Center, National; Institutes of Health, Bethesda, MD, USA.
Home collection and non-blood-based methods of testing for the human immunodeficiency virus.: Am J Health Syst Pharm. 1997 Oct 1;54(19):2232-5. Unique Identifier : AIDSLINE /MED97472488; Goetsch R; Minor JR; Piscitelli SC; Division of Pharmacovigilance and Epidemiology, Food and Drug; Administration, Rockville, MD, USA.
Esophageal candidiasis as a complication of inhaled corticosteroids.: Ann Allergy Asthma Immunol. 1997 Oct;79(4):333-8. Unique Identifier : AIDSLINE /MED98020249; Simon MR; Houser WL; Smith KA; Long PM; Department of Pediatrics, Wayne State University School of Medicine,; Detroit, Michigan, USA.; BACKGROUND: Oropharyngeal candidiasis is a well-described side effect of inhaled corticosteroids. Nevertheless, few cases of esophageal candidiasis have been reported. OBJECTIVE: To present a patient with esophageal candidiasis associated with inhaled corticosteroids. METHODS: Case report. RESULTS: Our patient is a 70
Distinct genotypic distributions of cytomegalovirus (CMV) envelope glycoprotein in bone marrow and renal transplant recipients with CMV disease.: Clin Diagn Lab Immunol. 1997 Sep;4(5):515-8. Unique Identifier : AIDSLINE /MED97445909; Woo PC; Lo CY; Lo SK; Siau H; Peiris JS; Wong SS; Luk WK; Chan TM; Lim WW; Yuen KY; Department of Microbiology, The University of Hong Kong, Hong Kong.; A prospective study of the spectrum of glycoprotein B (gB) and glycoprotein H (gH) genotypes of cytomegalovirus ( CMV ) was conducted with five categories of patients: viremic bone marrow-transplant (BMT) recipients who develop
Synthetic-peptide-based enzyme-linked immunosorbent assay for screening human serum or plasma for antibodies to human immunodeficiency virus type 1 and type 2.: Clin Diagn Lab Immunol. 1997 Sep;4(5):598-603. Unique Identifier : AIDSLINE /MED97445924; Gonzalez L; Boyle RW; Zhang M; Castillo J; Whittier S; Della-Latta P; Clarke LM; George JR; Fang X; Wang JG; Hosein B; Wang CY; United Biomedical, Inc., Hauppauge, New York 11788, USA.; A synthetic-peptide-based enzyme-linked immunosorbent assay (EIA) capable of screening for antibodies to both human immunodeficiency virus type 1 (HIV-1) and HIV-2 has been developed for use in blood banks and diagnostic laboratories. Microtiter wells are coated with two synthetic peptides, one corresponding to the hi
Dilution assessment of cervicovaginal secretions collected by vaginal washing to evaluate mucosal shedding of free human immunodeficiency virus.: Clin Diagn Lab Immunol. 1997 Sep;4(5):624-6. Unique Identifier : AIDSLINE /MED97445930; Mohamed AS; Becquart P; Hocini H; Metais P; Kazatchkine M; Belec L; Laboratoire de Virologie, Hopital Broussais, Paris, France.; A 10 mM concentration of lithium does not interfere with reverse transcription (RT) or PCR. Sampling of cervicovaginal fluid by vaginal washing, with lithium (10 mM) in the washing buffer as a marker of dilution, may be utilized to accurately determine in HIV-infected women, by quantitative RT-PCR, the genital sheddin
Differences in humoral responses to the p24 antigen between Ethiopian and Swedish human immunodeficiency virus type 1-infected patients may suggest influences from a T-helper 2-like phenotype.: Clin Diagn Lab Immunol. 1997 Sep;4(5):627-9. Unique Identifier : AIDSLINE /MED97445931; Kebede T; Britton S; Fehniger T; Vahlne A; Sallberg M; Department of Immunology, Microbiology, Pathology, and Infectious; Diseases, Karolinska Institutet, Huddinge Hospital, Sweden.; The levels of human immunodeficiency virus type 1 p24 antibodies and p24 antigen among 256 Ethiopians and Africans and 86 Swedes were compared. The elevated levels of total anti-p24 immunoglobulin G (IgG) and anti-p24 IgG4 among the Ethiopian and African patients suggest influences from T-helper-cell type 2-like respo
Antibodies to the hepatitis B e antigen (HBeAg) can be induced in HBeAg-transgenic mice by adoptive transfer of a specific T-helper 2 cell clone.: Clin Diagn Lab Immunol. 1997 Sep;4(5):630-2. Unique Identifier : AIDSLINE /MED97445932; Hultgren C; Milich DR; Sallberg M; Division of Clinical Virology, Huddinge University Hospital, Sweden.; Production of antibody to hepatitis B e antigen (HBeAg); i.e., anti-HBe antibody,) in HBeAg-transgenic mice is believed to be mediated by T-helper 2 (Th2) cells. Injection of an HBeAg-specific Th2 clone into HBeAg-transgenic H-2k mice induced anti-HBe antibody production, confirming the function of Th2 cells in this m
Inhibition of HIV-1 replication by retroviral vectors expressing monomeric and multimeric hammerhead ribozymes.: Gene Ther. 1997 Aug;4(8):861-7. Unique Identifier : AIDSLINE /MED97479364; Ramezani A; Ding SF; Joshi S; Department of Medical Genetics and Microbiology, Faculty of Medicine,; University of Toronto, Ontario, Canada.; Retroviral vectors were engineered to express monomeric and multimeric hammerhead ribozymes targeting one and nine highly conserved sites within the HIV-1 envelope (Env) coding region. In vitro, both the monomeric and multimeric ribozymes were shown to be active and cleave the target RNA containing the cleavage sites.
Enhancement of retroviral production from packaging cell lines expressing the human immunodeficiency type 1 VPU gene.: Gene Ther. 1997 Aug;4(8):868-74. Unique Identifier : AIDSLINE /MED97479365; Kobinger GP; Mouland AJ; Lalonde JP; Forget J; Cohen EA; Departement de Microbiologie et Immunologie, Faculte de Medecine,; Universite de Montreal, Quebec, Canada.; The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. Interestingly, Vpu was also shown to enhance the release of capsids produced by gag gene contructs of other retroviruses that lack a Vpu-like activity. To investigate the effect of Vpu expression on viral
Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells.: Immunity. 1997 Sep;7(3):401-9. Unique Identifier : AIDSLINE /MED97464539; McSorley SJ; Soldera S; Malherbe L; Carnaud C; Locksley RM; Flavell RA; Glaichenhaus N; Institut de Pharmacologie Moleculaire et Cellulaire, Centre National; de la Recherche Scientifique UPR411, Valbonne, France.; Recent experiments have suggested that tumor necrosis factor alpha (TNFalpha) can down-regulate islet-specific T cells and prevent the development of autoimmune diabetes. Here we demonstrate that transgenic mice expressing both TNFalpha and the Leishmania major LACK antigen in the pancreas RIP-TNFalpha/RIP-LACK) exhib
A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice.: Immunity. 1997 Oct;7(4):525-36. Unique Identifier : AIDSLINE /MED98014596; Hostert A; Tolaini M; Roderick K; Harker N; Norton T; Kioussis D; Division of Molecular Immunology, National Institute for Medical; Research, The Ridgeway, London, England.; The coreceptors CD4 and CD8 play a crucial role during thymocyte development and T cell effector function, and their expression is developmentally regulated. To determine the underlying molecular mechanisms of CD8 gene regulation we cloned the murine CD8 gene locus from genomic libraries and analyzed this region for d
An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.: Immunity. 1997 Oct;7(4):537-47. Unique Identifier : AIDSLINE /MED98014597; Ellmeier W; Sunshine MJ; Losos K; Hatam F; Littman DR; Division of Molecular Pathogenesis, Skirball Institute of Biomolecular; Medicine, New York University Medical Center, New York 10016, USA.; Positive selection of CD4+CD8+ T cells to the CD4+CD8- helper and CD4- CD8+ cytotoxic lineages is a multistep process that involves complex regulation of coreceptor gene expression. By analyzing expression of a reporter gene in transgenic mice, we have identified a DNA segment, located between the murine CD8beta and C
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.: Immunity. 1997 Oct;7(4):571-81. Unique Identifier : AIDSLINE /MED98014600; Robinson D; Shibuya K; Mui A; Zonin F; Murphy E; Sana T; Hartley SB; Menon S; Kastelein R; Bazan F; O'Garra A; Department of Immunobiology, DNAX Research Institute of Molecular and; Cellular Biology, Palo Alto, California 94304, USA.; In these studies, IFN gamma-inducing factor (IGIF), unlike IL-12, did not drive Th1 development in BALB/c or C57BL/6 mice, but like IL-1alpha, potentiated IL-12-driven Th1 development in BALB/c mice. IGIF and IL-12 synergized for IFN gamma production from Th1 cells. Unlike IL-1alpha, IGIF had no effect on Th2 cells. I
CD4: a co-receptor in the immune response and HIV infection.: Int J Biochem Cell Biol. 1997 Jun;29(6):871-5. Unique Identifier : AIDSLINE /MED97449786; Bowers K; Pitcher C; Marsh M; Medical Research Council Laboratory for Molecular Cell Biology,; University College London, U.K.; CD4 is a transmembrane glycoprotein of the immunoglobulin superfamily, expressed on developing thymocytes, major histocompatibility class II (class II MHC) restricted mature T lymphocytes and, in humans, on cells of the macrophage/monocyte lineage. On lymphoid cells, CD4 plays a critical role during thymocyte ontogeny
Management of silicone-induced cataract in AIDS patients treated for viral retinitis-associated retinal detachment.: Ophthalmic Surg Lasers. 1997 Oct;28(10):828-31. Unique Identifier : AIDSLINE /MED97477843; Korobelnik JF; Hannouche D; Cochereau I; Demers P; Hoang-Xuan T; Department of Ophthalmology, Bichat-Claude Bernard Hospital, Paris,; France.; BACKGROUND AND OBJECTIVE: To evaluate the outcome of cataract surgery for patients with acquired immunodeficiency syndrome AIDS) who underwent vitrectomy and silicone tamponade for viral retinitis-associated retinal detachment. PATIENTS AND METHODS: The authors retrospectively reviewed the data of five AIDS patients (
[A malabsorption syndrome, gastrointestinal leishmaniasis and HIV infection (letter)]: Gastroenterol Hepatol. 1997 Aug-Sep;20(7):386. Unique Identifier : AIDSLINE /MED97474897; Alguacil GF; Moreno J; Ortolano A; Hallal H
TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.: Mol Med. 1997 Aug;3(8):553-64. Unique Identifier : AIDSLINE /MED97453243; Fiala M; Looney DJ; Stins M; Way DD; Zhang L; Gan X; Chiappelli F; Schweitzer ES; Shapshak P; Weinand M; Graves MC; Witte M; Kim KS; Department of Medicine, UCLA School of Medicine 90095-1769, USA.; fiala@ucla.edu; BACKGROUND: HIV-1 invades the central nervous system early after infection when macrophage infiltration of the brain is low but myelin pallor is suggestive of blood-brain-barrier damage. High-level plasma viremia is a likely source of brain infection. To understand the invasion route, we investigated virus penetration
The J. David Gladstone Institutes.: Mol Med. 1997 Sep;3(9):569-71. Unique Identifier : AIDSLINE /MED97464994; Mahley RW; J. David Gladstone Institutes, San Francisco, CA 94141-9100, USA.; robert_mahley@quickmail.ucsf.edu
Wrong kind of chemokine research [editorial; comment]: Nat Med. 1997 Oct;3(10):1051. Unique Identifier : AIDSLINE /MED97475173
Are anti-HIV drugs an effective treatment? [letter]: Nat Med. 1997 Oct;3(10):1052. Unique Identifier : AIDSLINE /MED97475174; Karpas A; Ash S; Bainbridge D
CCR2 chemokine receptor and AIDS progression [letter; comment]: Nat Med. 1997 Oct;3(10):1052-3. Unique Identifier : AIDSLINE /MED97475175; Smith MW; Carrington M; Winkler C; Lomb D; Dean M; Huttley G; O'Brien SJ
AIDS vaccine trial. Publicity stunt or genuine attempt at progress? [news]: Nat Med. 1997 Oct;3(10):1055-6. Unique Identifier : AIDSLINE /MED97475177; Birmingham K
A chemokine trap for HIV co-receptors [news; comment] [see comments]: Nat Med. 1997 Oct;3(10):1074-5. Unique Identifier : AIDSLINE /MED97475186; Lusso P
Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy.: Nat Med. 1997 Oct;3(10):1102-9. Unique Identifier : AIDSLINE /MED97475197; Withers-Ward ES; Amado RG; Koka PS; Jamieson BD; Kaplan AH; Chen IS; Zack JA; Department of Microbiology and Immunology, UCLA School of Medicine; 90095, USA.; Stem cell gene therapy strategies for AIDS require that differentiation-inducing stromal elements of HIV-infected individuals remain functionally intact to support the maturation of exogenous progenitor cells into mature CD4+ cells. To investigate the feasibility of stem cell reconstitution strategies in AIDS, we used
Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy [see comments]: Nat Med. 1997 Oct;3(10):1110-6. Unique Identifier : AIDSLINE /MED97475198; Chen JD; Bai X; Yang AG; Cong Y; Chen SY; Department of Cancer Biology, Bowman Gray School of Medicine, Wake; Forest University, Winston-Salem, North Carolina 27157, USA.; CXC-chemokine receptor (CXCR)-4/fusin, a newly discovered co-receptor for T-cell line (T)-tropic HIV-1 virus, plays a critical role in T-tropic virus fusion and entry into permissive cells. The occurrence of T-tropic HIV viruses is associated with CD4-positive cell decline and progression to AIDS, suggesting that the
HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.: Nat Med. 1997 Oct;3(10):1117-23. Unique Identifier : AIDSLINE /MED97475199; Ayyavoo V; Mahboubi A; Mahalingam S; Ramalingam R; Kudchodkar S; Williams WV; Green DR; Weiner DB; Department of Pathology, University of Pennsylvania, Philadelphia; 19104, USA.; The HIV-1 accessory gene product Vpr can influence viral pathogenesis by affecting viral replication as well as host cell transcription and proliferation. We have investigated the effects of Vpr on host cell activation and confirm that it influences cellular proliferation. However, we have also found that Vpr modulate
The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression [see comments]: Nat Med. 1997 Oct;3(10):1160-2. Unique Identifier : AIDSLINE /MED97475208; Michael NL; Louie LG; Rohrbaugh AL; Schultz KA; Dayhoff DE; Wang CE; Sheppard HW; Division of Retrovirology, Walter Reed Army Institute of Research,; Rockville, Maryland 20850, USA.; Entry of human immunodeficiency virus type 1 (HIV-1) into target cells requires both CD4 (ref. 1, 2) and one of a growing number of G-protein-coupled seven-transmembrane receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 or CXCR4, although other receptors, including CCR2B an
In vivo HIV-1 frameshifting efficiency is directly related to the stability of the stem-loop stimulatory signal.: RNA. 1997 Oct;3(10):1153-8. Unique Identifier : AIDSLINE /MED97465799; Bidou L; Stahl G; Grima B; Liu H; Cassan M; Rousset JP; Genetique Moleculaire de la Traduction-Equipe d'accueil N 1831 de; I'Universite Pierre et Marie Curie, Institut de Genetique et; Microbiologie, URA CNRS 2225, Universite Paris-Sud, Orsay, France.; In many retroviruses, the expression of reverse transcriptase, protease, and integrase is dependent upon a -1 frameshift event. The frameshift signal is composed of a slippery sequence where the ribosome shifts, and a downstream stimulatory sequence. In most cases, the stimulatory sequence is a pseudoknot, but in some
Substrate structure requirements of the Pac1 ribonuclease from Schizosaccharmyces pombe.: RNA. 1997 Oct;3(10):1182-93. Unique Identifier : AIDSLINE /MED97465802; Rotondo G; Huang JY; Frendewey D; Department of Microbiology, New York University School of Medicine,; New York 10016, USA.; The Pac1 ribonuclease of Schizosaccharomyces pombe is a member of the RNase III family of double-strand-specific ribonucleases. To examine RNA structural features required for efficient cleavage by the Pac1 RNase, we tested a variety of double-stranded and hairpin RNAs as substrates for the enzyme. The Pac1 RNase requ
Adrenal carcinomas in AIDS. Report of three cases.: Clin Imaging. 1997 Sep-Oct;21(5):375-8. Unique Identifier : AIDSLINE /MED97462517; Ferrozzi F; Bova D; Campodonico F; Garlaschi G; Passari A; Pizzaferri P; Istituto di Scienze Radiologiche, Universita Degli Studi-Parma, Italy.; With the recent advances in treatment of AIDS, we have seen an increase in detection of malignant neoplasms in our patients. While some malignancies have an undoubted relationship with the HIV infection, others represent nothing more than sporadic reports and their relationship with the underlying immunological defici
Differential diagnosis of facial nerve palsy.: Sarcoidosis Vasc Diffuse Lung Dis. 1997 Sep;14(2):115-20. Unique Identifier : AIDSLINE /MED97451556; James DG; Royal Free Hospital, London, UK.; Facial nerve palsy is the most frequent neurological presentation of sarcoidosis. It occurs with equal frequency on the right or left side, and equally unilateral or bilateral. When bilateral facial palsy develops in a young adult, sarcoidosis is the most likely cause. In our series of 147 patients with ocular sarcoid
HIV infection in Rhode Island adolescents.: Med Health R I. 1997 Oct;80(10):331-3. Unique Identifier : AIDSLINE /MED98011171; Pugatch D; Rich JD; Flanigan TP; Providence, RI, USA. DPugatch@Lifepsan.org
Human immunodeficiency virus infection and sexually transmitted diseases.: Med Health R I. 1997 Oct;80(10):334-7. Unique Identifier : AIDSLINE /MED98011172; Uvin SC; Flanigan TP; Miriam Hospital, Brown University School of Medicine, Providence, RI; 02906, USA.
Changes in sexual behavior related to HIV/AIDS knowledge.: Med Health R I. 1997 Oct;80(10):341-2. Unique Identifier : AIDSLINE /MED98011174; Hesser JE; Kim H
[A matter of principle on HIV positivity (interview by Marit Fonn)]: Tidsskr Sykepl. 1997 Jun 17;85(11):18. Unique Identifier : AIDSLINE /MED98018178; Wenaes W
[HIV/AIDS--let the virus speak (interview by Olav Andre Manum)]: Tidsskr Sykepl. 1997 Jun 17;85(11):37. Unique Identifier : AIDSLINE /MED98018187; Ovlien T
[Nursing of AIDS patients (letter)]: Tidsskr Sykepl. 1997 Jun 17;85(11):7-8. Unique Identifier : AIDSLINE /MED98018173; Sprakehaug O
[Close up: Widar Wenaes, nurse supported by justice--following judgment (interview by Marit Fonn)]: Tidsskr Sykepl. 1997 Aug 19;85(13):20-2. Unique Identifier : AIDSLINE /MED98009738; Wenaes W
[Complete victory for HIV-positive nurse (news)]: Tidsskr Sykepl. 1997 Aug 19;85(13):4. Unique Identifier : AIDSLINE /MED98009732; Fonn M
Tennessee's AIDS Centers of Excellence Project.: Tenn Med. 1997 Oct;90(10):416-7. Unique Identifier : AIDSLINE /MED97465285; Long WJ
Treatment of patients with HIV in state of flux [see comments]: Todays Surg Nurse. 1997 Mar-Apr;19(2):18-20; quiz 33-4. Unique Identifier : AIDSLINE /MED97377631; Stephenson M; Protection of patients privacy is important professionally, legally, and personally. Nurses must use discretion when discussing the HIV status of a patient with others. Treating patients with HIV or AIDS involves protection of staff as well as the patient.
Contesting confidentiality [letter]: Todays Surg Nurse. 1997 Mar-Apr;19(2):6. Unique Identifier : AIDSLINE /MED97377629; Brown CL
HIV infection and the dermatologist: introduction.: Semin Cutan Med Surg. 1997 Sep;16(3):179-80. Unique Identifier : AIDSLINE /MED97444096; Cruz PD Jr
Human herpesvirus 8 and Kaposi's sarcoma.: Semin Cutan Med Surg. 1997 Sep;16(3):181-7. Unique Identifier : AIDSLINE /MED97444097; Dictor M; Department of Pathology, University of Lund Hospital, Sweden.; In the last 2 years, the discovery that the suspected causative agent of Kaposi s sarcoma (KS) is a new gamma-herpesvirus, called human herpesvirus type 8 (HHV8) or Kaposi s sarcoma-associated herpesvirus (KSHV), has been followed by studies showing it to be a sine qua non of all clinical forms of KS and a specific ma
Bacillary angiomatosis and other Bartonella species infections.: Semin Cutan Med Surg. 1997 Sep;16(3):188-99. Unique Identifier : AIDSLINE /MED97444098; Wong R; Tappero J; Cockerell CJ; Department of Dermatology, University of Texas Southwestern Medical; Center, Dallas, USA.; Infections with organisms of the genus Bartonella, for many years important only in South and Central America, have assumed significance in developing countries, especially in conjunction with the advent of the pandemic of the human immunodeficiency virus infection. New molecular and culture techniques have determined
Fungal infections in HIV-infected patients.: Semin Cutan Med Surg. 1997 Sep;16(3):200-12. Unique Identifier : AIDSLINE /MED97444099; Durden FM; Elewski B; Department of Dermatology, Case Western Reserve University, University; Hospitals of Cleveland, OH 44106, USA.; Opportunistic fungal infections are commonly encountered in the acquired immunodeficiency syndrome (AIDS) patient population. Fungal infections in the patient infected with the human immunodeficiency virus (HIV) are a major cause of morbidity and mortality. The yeasts Candida and Cryptococcus neoformans, the dimorphic
HIV-related psoriasis and Reiter's syndrome.: Semin Cutan Med Surg. 1997 Sep;16(3):213-8. Unique Identifier : AIDSLINE /MED97444100; Weitzul S; Duvic M; Department of Dermatology, University of Texas Southwestern Medical; Center, Dallas, USA.; Infection with the human immunodeficiency virus (HIV) is associated with the development of psoriasis and related disorders, including psoriatic arthritis, dactylitis and enthesitis, and Reiter s syndrome. The etiologic mechanisms remain unclear but most likely represent a combination of genetic and environmental fact
HIV-related eosinophilic folliculitis: a panel discussion.: Semin Cutan Med Surg. 1997 Sep;16(3):219-23. Unique Identifier : AIDSLINE /MED97444101; Majors MJ; Berger TG; Blauvelt A; Smith KJ; Turner ML; Cruz PD Jr; Department of Dermatology, University of Texas Southwestern Medical; Center, Dallas 75235-9292, USA.; Eosinophilic folliculitis is a common cause of morbidity in patients infected with the human immunodeficiency virus (HIV) and a marker of the acquired immunodeficiency syndrome (AIDS). No causative organism has yet been identified, although an aberrant Th2-type immune response to a follicular antigen appears relevant
Current antiretroviral therapy in the treatment of HIV infection.: Semin Cutan Med Surg. 1997 Sep;16(3):224-34. Unique Identifier : AIDSLINE /MED97444102; Chopra KF; Tyring SK; Department of Microbiology and Immunology, University of Texas Medical; Branch at Galveston, USA.; Since the introduction of the first antiretroviral agent, zidovudine ( AZT ) in 1987, much progress has been made in the chemotherapy of the human immunodeficiency virus (HIV). Currently nine antiretroviral agents are approved for the treatment of indiv
Treatment of HIV-related scabies with emphasis on the efficacy of ivermectin.: Semin Cutan Med Surg. 1997 Sep;16(3):235-40. Unique Identifier : AIDSLINE /MED97444103; Taplin D; Meinking TL; Department of Dermatology, University of Miami School of Medicine, FL; 33101, USA.; Since the mid-1980s, worldwide reports confirm that scabies in individuals infected with the human immunodeficiency virus (HIV) result in a wide range of-clinical manifestations which differ from those seen in immunocompetent patients. There is also general agreement that HIV-related scabies is more difficult to treat
Ultraviolet therapy of HIV-infected individuals: a panel discussion.: Semin Cutan Med Surg. 1997 Sep;16(3):241-5. Unique Identifier : AIDSLINE /MED97444104; Houpt KR; Beer JZ; Horn TD; Moy JA; Zmudzka BZ; Cruz PD Jr; Department of Dermatology, The University of Texas Southwestern; Medical Center, Dallas 75235-9069, USA.; Patients infected with the human immunodeficiency virus (HIV) frequently develop skin diseases that are responsive to ultraviolet (UV) radiation. Studies on the effects of UV on HIV and on the immune system in vitro and in transgenic animals have raised questions regarding the safety of UV exposure in these patients.
A community-based approach to the control of sexually transmitted diseases in the Northern Territory.: Aust N Z J Public Health. 1997 Aug;21(5):519-23. Unique Identifier : AIDSLINE /MED98003861; Bowden FJ; Bastian I; Johnston F; AIDS/STD Unit, Territory Health Services, Darwin, Casuarina, NT.; frank.bowden@nt.gov.au; A program to control sexually transmitted diseases (STDs) was undertaken during a Men s Health Week in a remote Aboriginal community in Western Arnhem Land, Northern Territory. A total of 151 men aged 13 years and over who attended over a five-day period underwent a full physical examination, and first-void urine spec
Senior school students' experiences and opinions of school-based HIV-AIDS education.: Aust N Z J Public Health. 1997 Aug;21(5):531-8. Unique Identifier : AIDSLINE /MED98003863; Lupton D; Tulloch J; Centre for Cultural Risk Research, School of Social Sciences and; Liberal Studies, Charles Sturt University, Bathurst, New South Wales.; This article reports the findings from the second part of a two-stage study that used both qualitative and quantitative methods to investigate the communication context of school-based HIV-AIDS education in state secondary schools in metropolitan and rural areas of New South Wales. The quantitative data are here descr
An exploration of the meaning and use of spirituality among women with HIV/AIDS.: Altern Ther Health Med. 1997 Sep;3(5):55-60. Unique Identifier : AIDSLINE /MED97433536; Guillory JA; Sowell R; Moneyham L; Seals B; Department of Community Health and Preventive Medicine, Morehouse; School of Medicine, Atlanta, Ga, USA.; Disease progression and the onset of AIDS slowly strip away the human form and dignity. As the physical body succumbs to the disease, those with HIV/AIDS search for meaning in life as they seek ways to prolong survival. The purpose of this study was to explore the meaning and use of spirituality in women infected with
Multicentric endobronchial smooth muscle tumors associated with the Epstein-Barr virus in an adult patient with the acquired immunodeficiency syndrome: a case report.: Cancer. 1997 Nov 15;80(10):1910-3. Unique Identifier : AIDSLINE /MED98031620; Bluhm JM; Yi ES; Diaz G; Colby TV; Colt HG; Division of Pulmonary and Critical Care Medicine, University of; California, San Diego Medical Center, 92103, USA.; BACKGROUND: The incidence of benign and malignant smooth-muscle tumors (leiomyomas and leiomyosarcomas) is increased in children with the acquired immunodeficiency syndrome (AIDS). Epstein-Barr virus (EBV) infection has been implicated in the pathogenesis of these tumors. Smooth muscle tumors in adults with AIDS are e
Mechanisms of bone lesions in multiple myeloma and lymphoma.: Cancer. 1997 Oct 15;80(8 Suppl):1557-63. Unique Identifier : AIDSLINE /MED98026745; Roodman GD; Department of Medicine/Hematology, Audie Murphy Veterans; Administration Hospital, San Antonio, Texas 78284, USA.; BACKGROUND: Bone lesions and hypercalcemia occur rarely in patients with hematologic malignancies, except those patients with multiple myeloma and adult T-cell leukemia/lymphoma (ATL) associated with the human T-cell leukemia/lymphoma virus-1 HTLV-1) virus. The primary mechanism for bone destruction in patients with m
Allergic contact dermatitis: understanding the immune response and potential for targeted therapy using cytokines.: Mol Med Today. 1997 Oct;3(10):423-8. Unique Identifier : AIDSLINE /MED98023326; Enk AH; Dept of Dermatology, University of Mainz, Germany.; Allergic contact dermatitis is the most common job-related disease of the western world. The only available treatments are avoidance of contact with the allergen and the use of potent corticosteroids. Recently, the role of cytokines in the pathogenesis of this disease has been studied and, besides defining the key mol
Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen.: Cancer Res. 1997 Oct 15;57(20):4570-7. Unique Identifier : AIDSLINE /MED98021980; Zaremba S; Barzaga E; Zhu M; Soares N; Tsang KY; Schlom J; Laboratory of Tumor Immunology and Biology, Division of Basic; Sciences, National Cancer Institute, Bethesda, Maryland 20892-1750,; USA.; A vaccination strategy designed to enhance the immunogenicity of self-antigens that are overexpressed in tumor cells is to identify and slightly modify immunodominant epitopes that elicit T-cell responses. The resultant T cells, however, must maintain their ability to recognize the native configuration of the peptide-
Association of human T-cell leukemia virus and myelodysplastic syndrome in a central European population.: Cancer Res. 1997 Nov 1;57(21):4718-21. Unique Identifier : AIDSLINE /MED98014552; Karlic H; Mostl M; Mucke H; Pavlova B; Pfeilstocker M; Heinz R; L. Boltzmann Institute for Leukemia Research and Hematology, Hanusch; Hospital, Vienna, Austria.; In addition to a few disorders such as acute T-cell leukemia that are typically associated with the human T-cell leukemia virus HTLV) 1 in endemic regions, this virus may also play a role in some other hematological diseases. Here, we examine the incidence of HTLV in hematological diseases from a nonendemic region in
Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo.: Cancer Res. 1997 Nov 1;57(21):4862-7. Unique Identifier : AIDSLINE /MED98014573; Etoh K; Tamiya S; Yamaguchi K; Okayama A; Tsubouchi H; Ideta T; Mueller N; Takatsuki K; Matsuoka M; Second Department of Internal Medicine, Kumamoto University School of; Medicine, Japan.; Clonal proliferation of human T-lymphotropic virus type I HTLV-I)-infected cells has been detected by Southern blot analysis and inverse PCR in patients with adult T-cell leukemia, patients with HTLV-I-associated diseases, and even in asymptomatic carriers. Combining inverse PCR with long PCR, we amplified the genomic
Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type I-infected lymphocytes by 13-cis-retinoic acid.: Cancer Res. 1997 Nov 1;57(21):4916-23. Unique Identifier : AIDSLINE /MED98014581; Furuke K; Sasada T; Ueda-Taniguchi Y; Yamauchi A; Inamoto T; Yamaoka Y; Masutani H; Yodoi J; Department of Biological Responses, Institute for Virus Research,; College of Medical Technology, Kyoto University, Japan.; We have shown that cell cycle progression of human T-cell leukemia virus type I (HTLV-I)-transformed T-cell lines was inhibited by 13-cis-retinoic acid (13cRA). In the present study, we report that 13cRA inhibited proliferation and induced cell death of peripheral blood mononuclear cells obtained from four patients wi
Comparative quantification of human cytomegalovirus DNA in blood of immunocompromised patients by PCR and Murex Hybrid Capture System.: Clin Diagn Virol. 1997 Aug;8(2):159-65. Unique Identifier : AIDSLINE /MED97462494; Baldanti F; Zavattoni M; Sarasini A; Gatti M; Chezzi L; Gerna G; Viral Diagnostic Service, IRCCS Policlinico S. Matteo, Pavia, Italy.; BACKGROUND: Monitoring of human cytomegalovirus (HCMV) load by quantification of antigenemia, viremia and DNAemia is helpful in the management of HCMV infections in immunocompromised patients. In fact, threshold values of these viral parameters are associated with the emergence of
Immune effector cells in idiopathic pulmonary fibrosis.: Curr Opin Pulm Med. 1997 Sep;3(5):348-55. Unique Identifier : AIDSLINE /MED97472577; Agostini C; Siviero M; Semenzato G; Universita di Padova, Dipartimento di Medicina Clinica e Sperimentale,; Italy.; Idiopathic pulmonary fibrosis (IPF) is a poorly understood immunomediated disorder that is characterized by three major features; influx of inflammatory cells into the lower respiratory tract, alveolar epithelial or capillary cell injury, and release of cytokines that stimulate proliferation of fibroblasts and type II
Treatment of nontuberculous mycobacterial infections: role of clarithromycin and azithromycin.: Clin Ther. 1997 Jul-Aug;19(4):626-38; discussion 603. Unique Identifier : AIDSLINE /MED98025616; Tartaglione T; The incidence of identification of nontuberculous mycobacteria has increased since the advent of the acquired immunodeficiency syndrome epidemic. Although Mycobacterium avium complex appears to be responsible for most episodes of nontuberculous disease, several other previously rare species are increasingly being dete
AIDS risk behaviors, knowledge, and attitudes among pregnant adolescents and young mothers.: Health Educ Behav. 1997 Oct;24(5):613-24. Unique Identifier : AIDSLINE /MED97453154; Koniak-Griffin D; Brecht ML; UCLA School of Nursing 90095-6919, USA. dkoniak@ucla.edu; This study assessed AIDS risk behaviors, knowledge, and related attitudes of pregnant adolescents and young mothers (n = 151). Results revealed that a substantial portion of the sample engaged in sexual behaviors (e.g., unprotected sex and multiple sex partners) that increased their risk for acquiring HIV and possibly
Hedgehogs, foxes, and a new science.: Nat Biotechnol. 1997 Sep;15(9):819. Unique Identifier : AIDSLINE /MED97451434; DeLisi C; Cantor C; Weng Z; College of Engineering, Boston University, MA 02215.; delisi@enga.bu.edu
HIV vector challenges gene therapy oversight [news]: Nat Biotechnol. 1997 Sep;15(9):832. Unique Identifier : AIDSLINE /MED97451437; Fox JL
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.: Nat Biotechnol. 1997 Sep;15(9):871-5. Unique Identifier : AIDSLINE /MED97451449; Zufferey R; Nagy D; Mandel RJ; Naldini L; Trono D; Salk Institute, La Jolla, CA 92037-1099, USA.; Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vivo delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted. Thi
Ribozyme therapeutics.: Nat Biotechnol. 1997 Sep;15(9):921-2. Unique Identifier : AIDSLINE /MED97451459; Persidis A; Argonex Inc., Charlottesville, VA 22901, USA. apersidis@argonex.com
KSHV and Kaposi's sarcoma: the end of the beginning?: Cell. 1997 Oct 17;91(2):157-60. Unique Identifier : AIDSLINE /MED98004219; Ganem D; Howard Hughes Medical Institute, Department of Microbiology,; University of California Medical Center, San Francisco 94143-0414,; USA.
The p38 mitogen-activated protein kinase pathway in activated and anergic Th1 cells.: Cell Immunol. 1997 Sep 15;180(2):116-23. Unique Identifier : AIDSLINE /MED98000948; DeSilva DR; Jones EA; Feeser WS; Manos EJ; Scherle PA; Inflammatory Diseases Research, Dupont Merck Pharmaceutical Company,; Wilmington, Delaware 19880-0400, USA.; Stimulation of T cells through the TCR leads to activation of the mitogen-activated protein kinase (MAPK) family members ERK extracellular signal-regulated kinase) and JNK (jun NH2-terminal kinase). These kinases act in synergy to increase the activity of the transcription factor AP-1 which is involved in the transcri
Human T lymphotropic virus type I (HTLV-I)-specific T helper cell responses from HTLV-I seronegative patients with chronic myelopathy and MS in Japan.: Mult Scler. 1996 Feb;1(4):200-3. Unique Identifier : AIDSLINE /MED98005294; Nishimura M; Jacobson S; Uchiyama T; Ohta M; Saida T; Department of Neurology and Clinical Research Center, Utano National; Hospital, Kyoto, Japan.; Human T lymphotropic virus type I (HTLV-I) is a human retrovirus etiologically linked to Adult T cell leukemia (ATL) and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although most HAM/TSP patients have high anti-HTLV-I antibody titers in their sera, HTLV-I infected but seronegative patients wit
Psychobiology of HIV infection.: Crit Rev Neurobiol. 1997;11(4):289-321. Unique Identifier : AIDSLINE /MED97477782; Cole SW; Kemeny ME; UCLA, Department of Hematology-Oncology 90024-1563, USA.; This review surveys evidence relevant to the proposition that psychobiologic factors may influence the progress of infection with human immunodeficiency virus Type 1 (HIV-1). Little research has directly examined the influence of psychobiologic factors on the pathogenetic mechanisms underlying HIV progression. However
Generalizations of current status data with applications.: Lifetime Data Anal. 1995;1(1):101-9. Unique Identifier : AIDSLINE /MED98006498; Jewell NP; Laan MV; Division of Biostatistics, University of California, USA.; In estimation of a survival function, current status data arises when the only information available on individuals is their survival status at a single monitoring time. Here, we briefly review extensions of this form of data structure in two directions: (i) doubly censored current status data, where there is incomple
Survival trees with time-dependent covariates: application to estimating changes in the incubation period of AIDS.: Lifetime Data Anal. 1995;1(1):35-47. Unique Identifier : AIDSLINE /MED98006493; Bacchetti P; Segal MR; Department of Epidemiology and Biostatistics, University of; California, San Francisco 94143-0840, USA. peter@biostat.ucsf.edu; Tree-structured methods for exploratory data analysis have previously been extended to right-censored survival data. We further extend these methods to allow for truncation and time-dependent covariates. We apply the new methods to a data set on incubation times of acquired immunodeficiency syndrome (AIDS), using cale
Gaussian models for degradation processes-Part I: Methods for the analysis of biomarker data.: Lifetime Data Anal. 1995;1(2):131-44. Unique Identifier : AIDSLINE /MED98006500; Doksum KA; Normand SL; University of California, Berkeley, USA.; We present two stochastic models that describe the relationship between biomarker process values at random time points, event times, and a vector of covariates. In both models the biomarker processes are degradation processes that represent the decay of systems over time. In the first model the biomarker process is a
Optimizing combination chemotherapy for Kaposi's sarcoma [comment]: Cancer J Sci Am. 1997 Sep-Oct;3(5):268-70. Unique Identifier : AIDSLINE /MED97468004; Yarchoan R; Little R; HIV and AIDS Malignancy Branch, National Cancer Institute, National; Institutes of Health, Bethesda, MD 20892-1906, USA.
AIDS Clinical Trials Group Study 094: a phase I/II trial of ABV chemotherapy with zidovudine and recombinant human GM-CSF in AIDS-related Kaposi's sarcoma [see comments]: Cancer J Sci Am. 1997 Sep-Oct;3(5):278-83. Unique Identifier : AIDSLINE /MED97468007; Gill PS; Mitsuyasu RT; Montgomery T; Huang J; Cabriales S; Testa M; Espina BM; Levine AM; Miles SA; Department of Internal Medicine, University of Southern California; School of Medicine, Los Angeles, USA.; PURPOSE: To define the maximum tolerated dose of doxorubicin when combined with fixed doses of bleomycin, vincristine, zidovudine, and recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) in patients with advanced AIDS-related Kaposi s sarcoma. PATIENTS AND METHODS: Twenty male patients were t
Evaluation of immunodominant epitopes of human T-lymphotropic virus type 1 (HTLV-I) using synthetic peptides.: Biomed Pept Proteins Nucleic Acids. 1995;1(3):117-22. Unique Identifier : AIDSLINE /MED98005199; Lairmore MD; Lal RB; Kaumaya PT; Center for Retrovirus Research, College of Veterinary Medicine,; Atlanta, GA, USA.; Human T-lymphotropic virus type 1 (HTLV-I) causes adult T-cell leukemia/lymphoma (ATLL) and has been associated with a variety of immunologically-mediated diseases. Recently, the immunodominant epitopes of HTLV-I have begun to be defined through the utilization of synthetic peptides and recombinant proteins. Strategie
Rapid desilylation of oligoribonucleotides at elevated temperatures: cleavage activity in ribozyme-substrate assays.: Biomed Pept Proteins Nucleic Acids. 1995;1(4):227-30. Unique Identifier : AIDSLINE /MED98005193; Vinayak R; Andrus A; Hampel A; Division of Perkin Elmer Corporation, Foster City, CA 94404, USA.; Treatment of 2 -O-silyl-oligoribonucleotides with triethylamine trihydrofluoride in DMF at 55 degrees C for 1 h effected complete desilylation. The product was isolated by a single addition of 1-butanol to the reaction mixture. The resulting RNA was found to be identical with that obtained by traditional desilylation
Affinity purification of a correctly folded fragment of synthetic HIV-1 mRNA using a HIV-1 Rev peptide-ligand.: Biomed Pept Proteins Nucleic Acids. 1996;2(2):47-50. Unique Identifier : AIDSLINE /MED98005183; Englebretsen DR; Scanlon MJ; West ML; Centre for Drug Design and Development, University of Queensland, St.; Lucia, Australia.; Formation of a macromolecular complex between the RNA binding protein HIV-1 Rev and HIV-1 mRNA is an essential prerequisite for nuclear export and subsequent expression of HIV-1 mRNA. The arginine rich peptide TRQARRNRRRRWRARQR, corresponding to residues 34-50 of HIV-1 Rev, contains the mRNA binding motif. We prepared
HIV risk perception, risk behavior, and seroprevalence among female commercial sex workers in Georgetown, Guyana.: Rev Panam Salud Publica. 1997 Jun;1(6):451-9. Unique Identifier : AIDSLINE /MED97364458; Carter KH; Harry BP; Jeune M; Nicholson D; Pan American Health Organization, Georgetown, Guyana.; A study of 108 female sex workers engaged in prostitution in Georgetown, Guyana , was made in April 1993. Based on interviews and procurement of blood samples, the study investigated relationships between HIV seroprevalences and AIDS knowledge, risk behaviors, client characteristics
Communicable diseases surveillance.: Commun Dis Intell. 1997 Sep 18;21(19):270-8. Unique Identifier : AIDSLINE /MED97462062
Restoration of the immunocompetence by IL-2 activation and TCR-CD3 engagement of the in vivo anergized tumor-specific CTL from lung cancer patients.: J Immunother. 1997 Sep;20(5):354-64. Unique Identifier : AIDSLINE /MED97477809; Chen YM; Yang WK; Whang-Peng J; Tsai WY; Hung YM; Yang DM; Lin WC; Perng RP; Ting CC; Chest Department, Veterans General Hospital-Taipei, Taiwan, R.O.C.; The present study investigates the nature of the immunosuppressed state of the lymphocytes obtained from the malignant pleural effusion (effusion associated lymphocytes, EAL) of lung cancer patients. The immunocompetence of EAL from 13 patients was assessed by determining their T-helper cell phenotype, proliferative r
Characterization of tumor-infiltrating lymphocytes derived from human tumors for use as adoptive immunotherapy of cancer.: J Immunother. 1997 Sep;20(5):377-86. Unique Identifier : AIDSLINE /MED97477812; Schiltz PM; Beutel LD; Nayak SK; Dillman RO; Patty and George Hoag Cancer Center, Newport Beach, California, USA.; From 1991 to 1995, we initiated cultures of 94 fresh tumor samples of various histologies in an effort to grow tumor-infiltrating lymphocytes (TIL) using flasks and subsequent expansion in semipermeable bags. The five most prevalent tumor types from which TIL were successfully initiated were melanoma 25 successful ini
Interferon-alpha neutralizing antibodies in HIV and chronic HCV patients treated with natural-source human leukocyte-derived interferon-alpha n3.: Hum Antibodies. 1997;8(3):129-36. Unique Identifier : AIDSLINE /MED97463299; Zhao XX; Hua J; Smith T; Ferencz-Biro K; Liao MJ; Rashidbaigi A; Interferon Sciences, New Brunswick, NJ 08901-3605, USA.; Human leukocyte-derived IFN-alpha n3 (Alferon N Injection) was administered subcutaneously to treat 20 patients with asymptomatic human immunodeficiency virus type 1 (HIV-1) and 141 patients with chronic hepatitis C virus (HCV) infections. The treatment of HIV-1 and HCV patients, previously untreated with any IFN prep
[Trace elements in biological samples and immunologic parameters in environmentally exposed populations (preliminary study)]: G Ital Med Lav Ergon. 1997 Jan-Mar;19(1):53-5. Unique Identifier : AIDSLINE /MED97434683; Boscolo P; Di Gioacchino M; Spano A; Di Giacomo F; Ballone E; D'Isidoro G; Cavallucci E; Giuliano G; Centro di Medicina del Lavoro ed Ergoftalmologia, Dipartimento di; Scienze, Statistica Medica, Universita G. D'Annunzio, Chieti.; In non-smoking policemen from a town of Central Italy , blood CD4+ lymphocytes were reduced and CD8+ were increased as compared with a control group. This immunological alteration was not evident in the smoking policemen. Urine lead (marker of exposure to toxic agents produced by tra
Treatment of posttransplantation hepatitis B.: Liver Transpl Surg. 1997 Sep;3(5 Suppl 1):S8-12. Unique Identifier : AIDSLINE /MED98018579; Perrillo RP; Section of Gastroenterology and Hepatology, Ochsner Clinic, New; Orleans, LA 70121, USA.
Diagnosis of disseminated mycobacterial infection: testing a simple and inexpensive method for use in developing countries.: Bull World Health Organ. 1997;75(4):361-6. Unique Identifier : AIDSLINE /MED98002367; Fandinho FC; Grinsztejn B; Veloso VG; Lourenco MC; Werneck-Barroso E; Joao E; Nogueira SA; Fonseca L de S; Microbiology Institute, Federal University of Rio de Janeiro, Brazil.; With the development of the acquired immunodeficiency syndrome AIDS) epidemic, the isolation of mycobacteria from blood has become a common problem for clinical laboratories. In this study two methods were used for the recovery of mycobacteria from blood specimens obtained from AIDS patients: (1) direct inoculation of
Apoptotic DNA fragmentation, and its in vitro prevention by nicotinamide, in lymphocytes from HIV-1-seropositive patients and in HIV-1-infected MT-4 cells.: Cell Biochem Funct. 1997 Sep;15(3):171-9. Unique Identifier : AIDSLINE /MED98020789; Savarino A; Martini C; Orofino GC; Cantamessa C; Castelli L; Pich PG; Sinicco A; Pugliese A; Department of Medical and Surgical Sciences, University of Turin,; Italy.; Apoptosis seems to play an important role in the decline of CD4+ T-cells in patients infected with HIV-1. Moreover, extensive interest in apoptosis comes from the observation that it correlates both with the progression and the severity of HIV-1 infection. A cross-sectional study was made to evaluate whether such corr
Modification of swelling-contraction-aggregation processes in rat muscle mitochondria by the 1,4-dihydropyridines, cerebrocrast and glutapyrone, themselves and in the presence of azidothymidine.: Cell Biochem Funct. 1997 Sep;15(3):211-20. Unique Identifier : AIDSLINE /MED98020794; Velena A; Skujins A; Svirskis S; Bisenieks E; Uldrikis J; Poikans J; Duburs G; Klusa V; Latvian Institute of Organic Synthesis, Riga, Latvia.; The influence of the 1,4-dihydropyridines (DHPs), water-soluble glutapyrone available as sodium, potassium and ammonium salts of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-DHP-4-carboxamide)glutar- ic acid, from one side, and a lipophylic cerebrocrast, 2-propoxyethyl 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-DHP-3,5-
Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1/LFA-1 adhesion.: Circulation. 1997 Oct 7;96(7):2247-53. Unique Identifier : AIDSLINE /MED97477134; Isobe M; Suzuki J; Yamazaki S; Yazaki Y; Horie S; Okubo Y; Maemura K; Yazaki Y; Sekiguchi M; First Department of Internal Medicine, Shinshu University School of; Medicine, Matsumoto, Japan. isobemi@gipac.shinshu-u.ac.jp; BACKGROUND: Specific immune tolerance to cardiac allografts is induced by anti-ICAM-1 and anti-LFA-1 MAbs. Although the expression of the Th1 cytokines IL-2 and IFN-gamma is shown to increase in association with acute rejection, the roles of cytokines in the induction
IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis.: Clin Exp Immunol. 1997 Oct;110(1):114-21. Unique Identifier : AIDSLINE /MED98013206; Till S; Walker S; Dickason R; Huston D; O'Brien F; Lamb J; Kay AB; Corrigan C; Durham S; Upper Respiratory Medicine, Imperial College School of Medicine at; National Heart and Lung Institute, London, UK.; Grass pollen immunotherapy for the treatment of seasonal allergic rhinitis ( summer hayfever ) results in improvement in symptoms, a reduction in the early and late phase responses to allergen provocation and decreased tissue eosinophilia. Immunotherapy may act by altering the pattern of cytokine production by allerge
In vitro measurement of cytotoxic T cell activity does not predict clinical progression in paediatric HIV disease--two case studies.: Clin Exp Immunol. 1997 Oct;110(1):15-21. Unique Identifier : AIDSLINE /MED98013192; Froebel KS; Mok JY; Aldhous MC; Armitage MP; Arnott M; Reynolds LM; Peutherer JF; Burns SM; Centre for HIV Research, University of Edinburgh, UK.; Cytotoxic T cells are believed to be an important immune response in HIV infection, both in the initial response to viraemia, and in controlling HIV replication and maintaining clinical stability. We report here the detailed findings in two vertically infected children, from the Edinburgh perinatal cohort. Both were c
Altered sialylation of alveolar macrophages in HIV-1-infected individuals.: Clin Exp Immunol. 1997 Oct;110(1):22-5. Unique Identifier : AIDSLINE /MED98013193; Perrin C; Giordanengo V; Bannwarth S; Blaive B; Lefebvre JC; Service de Pneumologie and Faculte de Medecine, Nice, France.; In previous studies, we have demonstrated that O-glycans at the surface of HIV-1-infected cell lines were hyposialylated. Moreover, we and others have shown that HIV+ individuals produced autoantibodies that react with hyposialylated CD43, on T cell lines. Since the autoantigen responsible for this abnormal immune res
Cell-mediated immune responses to mycobacterial antigens in patients with pulmonary tuberculosis and HIV infection.: Clin Exp Immunol. 1997 Oct;110(1):26-34. Unique Identifier : AIDSLINE /MED98013194; Silveira H; Ordway D; Dockrell H; Jackson M; Ventura F; Centro de Malaria e Outras Doencas Tropicais/IHMT, UNL, Lisboa,; Portugal.; Lymphocyte proliferation and cytokine responses induced by a panel of mycobacterial antigens were compared in Portuguese donors with pulmonary tuberculosis (TB) with or without HIV co-infection, HIV+ patients and healthy Mantoux-positive controls. Control donors showed stronger proliferative responses than any of the
Decreased expression of cytokines that induce type 1 helper T cell/interferon-gamma responses in genetically susceptible mice infected with Mycobacterium avium.: Clin Immunol Immunopathol. 1997 Oct;85(1):112-6. Unique Identifier : AIDSLINE /MED97467787; Kobayashi K; Nakata N; Kai M; Kasama T; Hanyuda Y; Hatano Y; Department of Host Defenses, Leprosy Research Center, National; Institute of Infectious Diseases, Tokyo, Japan.; kaz-koba@sa2.so-net.or.jp; Mycobacterium avium is an intracellular microorganism that infects and multiplies within macrophages. Cell-mediated immunity plays an important role in host defense. Two cytokines, interleukin 12 (IL-12) and interferon-gamma-inducing factor IGIF), produced mainly by macrophages, are critical for the development of typ
T lymphocyte subpopulations in anorexia nervosa refeeding [letter; comment]: Clin Immunol Immunopathol. 1997 Oct;85(1):117. Unique Identifier : AIDSLINE /MED97467788; Pomeroy C
Lack of associations of chemotactic cytokines with viral burden, disease progression, or lymphocyte subsets in HIV-infected individuals.: Clin Immunol Immunopathol. 1997 Oct;85(1):21-7. Unique Identifier : AIDSLINE /MED97467774; Krowka JF; Gesner ML; Ascher MS; Sheppard HW; Viral and Rickettsial Disease Laboratory, Division of Communicable; Disease Control, California Department of Health Services, Berkeley; 94704, USA.; Plasma samples from HIV-infected (HIV+) rapid progressors (RP) and nonprogressors (NP) in the San Francisco Men s Health Study showed significantly elevated levels of RANTES but not macrophage inflammatory protein 1 (MIP1) alpha or MIP1 beta in comparison to HIV-seronegative (HIV-) controls. In 32 individuals who beca
Prevalence of cryoglobulins and hepatitis C virus infection in HIV-infected patients.: Clin Exp Rheumatol. 1997 Sep-Oct;15(5):523-7. Unique Identifier : AIDSLINE /MED97453098; Cohen P; Roulot D; Ferriere F; Nguyen QT; Lortholary O; Jarrousse B; Deny P; Coste T; Robineau M; Guillevin L; Department of Internal Medicine, Hopital Avicenne, Universite; Paris-Nord, Bobigny, France.; PURPOSE AND METHODS: In order to evaluate the prevalence of positive hepatitis C virus (HCV) serology and cryoglobulinemia in human immunodeficiency virus (HIV)-infected patients, the prevalence and the clinical significance of cryoglobulinemia were prospectively studied in a cohort of 86 HIV-infected subjects seen as
Orthopaedic surgery in hemophilic patients with human immunodeficiency virus.: Clin Orthop. 1997 Oct;(343):81-7. Unique Identifier : AIDSLINE /MED98004970; Phillips AM; Sabin CA; Ribbans WJ; Lee CA; Royal Free Hospital, Northampton, United Kingdom.; Patients registered at the author s hemophilia center between 1982 and 1994 were studied to establish whether major orthopaedic surgical procedures accelerate the fall of CD4 lymphocyte counts of patients with hemophilia who are infected with the human immunodeficiency virus, and whether patients who had surgery had d
Therapeutic options in the management of hemophilic synovitis.: Clin Orthop. 1997 Oct;(343):88-92. Unique Identifier : AIDSLINE /MED98004971; Gilbert MS; Radomisli TE; Department of Orthopaedic Surgery, Mount Sinai School of Medicine, New; York, NY, USA.; There is a complex relationship between recurrent bleeding, synovitis, and the development of arthritis in the patient with hemophilia. There are many options available for the treatment of recurrent bleeding and hemophilic synovitis, indicating that none works very well. Conservative treatment, including replacement
Clinical pharmacokinetics of stavudine.: Clin Pharmacokinet. 1997 Oct;33(4):276-84. Unique Identifier : AIDSLINE /MED98001855; Rana KZ; Dudley MN; Antiinfective Pharmacology Research Unit, University of Rhode Island; College of Pharmacy, Roger Williams Medical Center, Providence, USA.; Canark@aol.com; Stavudine ( d4T ) is a pyrimidine nucleoside analogue used in the treatment of human immunodeficiency virus (HIV) infection. It inhibits viral reverse transcriptase as do zidovudine (
Severe pulmonary hypertension without significant pulmonary parenchymal disease in a pediatric patient with acquired immunodeficiency syndrome.: Clin Pediatr (Phila). 1992 Oct;31(10):629-31. Unique Identifier : AIDSLINE /MED98005963; Rhodes J; Schiller MS; Montoya CH; Fikrig S; Department of Pediatric Cardiology, Children's Medical Center of; Brooklyn, New York, USA.
N-acetylation among HIV-positive patients and patients with AIDS: when is fast, fast and slow, slow?: Clin Pharmacol Ther. 1997 Sep;62(3):261-71. Unique Identifier : AIDSLINE /MED97472231; O'Neil WM; Gilfix BM; DiGirolamo A; Tsoukas CM; Wainer IW; Division of Experimental Medicine, McGill University Department of; Medicine, Montreal, Quebec, Canada.; BACKGROUND: The discrepancy between genotype and expressed phenotype of the polymorphic N-acetyltransferase (NAT2) has been suggested by separate genotypic and phenotypic studies in populations with human immunodeficiency virus (HIV). Only one study has examined both genotype and phenotype in the same population, and
Osteoarticular and muscle infectious lesions in patients with the human immunodeficiency virus.: Clin Rheumatol. 1997 Sep;16(5):450-3. Unique Identifier : AIDSLINE /MED98006361; Belzunegui J; Gonzalez C; Lopez L; Plazaola I; Maiz O; Figueroa M; Rheumatology Unit, Hosp. NS Aranzazu, San Sebastian, Spain.; Between 1988 and 1995, 1832 HIV positive patients were evaluated in our institution. We studied the epidemiologic, immunologic and bacteriologic data, laboratory tests, and X-Ray films in those with musculoskeletal infection. We reviewed twenty-one cases of musculoskeletal infection in twenty patients aged 23-35 years
Fusospirochetal superinfection of pre-existing oral lesion in patients with acquired immunodeficiency syndrome.: Diagn Microbiol Infect Dis. 1997 Sep;29(1):51-3. Unique Identifier : AIDSLINE /MED98011500; Bottone EJ; Lee P; Department of Medicine, Mount Sinai Hospital, New York, New York; 10029, USA.; Three patients with AIDS presented with nonbleeding, painful, fetid, oral ulcers overlaid with a grayish-black semiadherent membrane at the sites of a pre-existing lesion. These lesions persisted despite treatment directed toward the primary etiology cytomegalovirus , Kaposi s sarco
Nonresponse bias in a national study of dentists' infection control practices and attitudes related to HIV.: Community Dent Oral Epidemiol. 1997 Aug;25(4):319-23. Unique Identifier : AIDSLINE /MED97473968; McCarthy GM; MacDonald JK; Faculty of Dentistry, University of Western Ontario, London, Canada.; gmccarth@julian.uwo.ca; The aim was to investigate late response and nonresponse bias in a survey related to HIV and infection control. Questionnaires with ID numbers were mailed to a stratified random sample of dentists in Canada with additional mailings 4 and 7 weeks later n = 6444). We compared respons
A review of the design of vaccine efficacy trials and a proposal for the design of the VA Cooperative Study of Active Immunotherapy of HIV Infection.: Control Clin Trials. 1997 Oct;18(5):397-419. Unique Identifier : AIDSLINE /MED97461057; Peduzzi P; Donta S; Iwane M; Cooperative Studies Program, VA Medical Center, West Haven, CT 06516,; USA.; We review the design of vaccine trials based on a search of the medical literature over the past four years, and present the proposed design of a therapeutic HIV vaccine efficacy study by the Department of Veterans Affairs Cooperative Studies Program. We explore the reasons for the atypical design of many vaccine tria
The relationship between study design, results, and reporting of randomized clinical trials of HIV infection.: Control Clin Trials. 1997 Oct;18(5):431-44. Unique Identifier : AIDSLINE /MED97461059; Ioannidis JP; Cappelleri JC; Sacks HS; Lau J; Division of Geographic Medicine and Infectious Diseases, New England; Medical Center Hospitals, Tufts University School of Medicine, Boston,; Massachusetts, USA.; We examined whether the study design of randomized clinical trials for medications against human immunodeficiency virus (HIV) may affect the results and whether the outcomes of these trials affect reporting and publication. We used a database of 71 published randomized HIV-related drug efficacy trials and considered t
An immunohistochemical study of TNF-alpha in optic nerves from AIDS patients.: Curr Eye Res. 1997 Oct;16(10):1064-8. Unique Identifier : AIDSLINE /MED97471920; Lin XH; Kashima Y; Khan M; Heller KB; Gu XZ; Sadun AA; Department of Ophthalmology, Doheny Eye Institute, University of; Southern California, Los Angeles 90033, USA.; PURPOSE: Both in vitro and in vivo studies have implicated a role for tumor necrosis factor (TNF-alpha) in the pathology of demyelinating diseases. The purpose of this study was to address the hypothesis that TNF-alpha is a mediator of AIDS-related optic nerve injury and to determine the cell types involved in the pro
HIV antibodies: further questions and a plea for clarification.: Curr Med Res Opin. 1997;13(10):627-34. Unique Identifier : AIDSLINE /MED97468053; Papadopulos-Eleopulos E; Turner VF; Papadimitriou JM; Stewart G; Causer D; Department of Medical Physics, Royal Perth Hospital, Western; Australia.; The existence of specific antibody/protein reactions is the crucial assumption underlying proof of HIV isolation, proof of HIV infection and the causative role of HIV in AIDS. However, since 1. antibodies which react with the HIV proteins arise following allogenic stimuli in non-HIV-infected animals and humans, as w
Characterization of amiodarone pneumonitis as related to inflammatory cells and surfactant apoprotein.: Chest. 1997 Oct;112(4):1068-74. Unique Identifier : AIDSLINE /MED98022142; Nagata N; Suematsu R; Yoshii C; Miyazaki H; Sueishi K; Kido M; Division of Respiratory Diseases, School of Medicine, University of; Occupational and Environmental Health, Kitakyushu, Japan.; STUDY OBJECTIVE: To characterize the inflammation observed in amiodarone-induced pneumonitis. DESIGN: The density of inflammatory cells in BAL fluid (BALF) and lung interstitium was quantified in a rat model of amiodarone pneumonitis. Immunoperoxidase staining for surfactant apoprotein was evaluated in lung tissue. AN
Lymphocytic alveolitis after primary HIV infection with CMV coinfection.: Chest. 1997 Oct;112(4):1127-8. Unique Identifier : AIDSLINE /MED98022153; Jouveshomme S; Couderc LJ; Ferchal F; Vignon D; Autran B; Balloul E; Caubarrere I; Service de Pneumologie, Hopital Foch, Suresnes, France.; Herein is a report of an adult case of primary HIV infection with cytomegalovirus coinfection causing cough, fever, and lymphocytic alveolitis. Primary HIV infection has not been previously reported as a cause of lymphocytic alveolitis.
Cross regulation by IL-10 and IL-2/IL-12 of the helper T cells and the cytolytic activity of lymphocytes from malignant effusions of lung cancer patients.: Chest. 1997 Oct;112(4):960-6. Unique Identifier : AIDSLINE /MED98022126; Chen YM; Yang WK; Ting CC; Tsai WY; Yang DM; Whang-Peng J; Perng RP; Chest Department, Veterans General Hospital-Taipei, Taiwan, ROC.; STUDY OBJECTIVE: Our previous report demonstrated that there was impairment of local cellular immunity with elevated interleukin-10 (IL-10) and undetectable IL-12 in neoplastic pleural effusion. These findings suggest that the local immune reactions favor the T-helper type 2 (Th2) pathway instead of Th1 pathway. The p
[Transmission of HIV by an infected surgeon in France]: Chirurg. 1997 Aug;68(8):Suppl 240. Unique Identifier : AIDSLINE /MED97443433
Suppression of HIV-1 replication by propolis and its immunoregulatory effect.: Drugs Exp Clin Res. 1997;23(2):89-96. Unique Identifier : AIDSLINE /MED97454978; Harish Z; Rubinstein A; Golodner M; Elmaliah M; Mizrachi Y; Albert Einstein College of Medicine, Department of Pediatrics,; Microbiology and Immunology, Bronx, New York 10461, USA.; In the current study we show that propolis, a non-toxic natural bee-hive product, suppresses HIV-1 replication and modulates in vitro immune responses. CEM cells were treated with propolis at nontoxic concentrations prior to or following infection with HIV-1. Propolis abolished syncytium formation at 4.5 micrograms/ml
In vitro metabolism of indinavir in the human fetal liver microsomes.: Drug Metab Dispos. 1997 Oct;25(10):1219-22. Unique Identifier : AIDSLINE /MED97464559; Chiba M; Nshime JA; Lin JH; Department of Drug Metabolism I, Merck Research Laboratories, West; Point, PA 19486, USA. Masato_Chiba@merck.com; In vitro microsomal formation of primary metabolites of indinavir CRIXIVAN, MK-0639, L-735,524), an HIV protease inhibitor, were qualitatively similar among the different developmental stages in humans, although the fetal liver had a lower capability
Evaluation of the effect of fluconazole on the pharmacokinetics of ritonavir.: Drug Metab Dispos. 1997 Sep;25(9):1104-6. Unique Identifier : AIDSLINE /MED97456315; Cato A 3rd; Cao G; Hsu A; Cavanaugh J; Leonard J; Granneman R; Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL; 60064, USA.; The effects of fluconazole on the pharmacokinetics of the HIV protease inhibitor ritonavir were investigated after multiple dosing in an open-label study. In this randomized, two-period crossover study, eight healthy subjects received ritonavir alone 200 mg every 6 hr for 4 days) and ritonavir with fluconazole 400 mg
Social network characteristics and injecting HIV-risk behaviors among street injection drug users.: Drug Alcohol Depend. 1997 Aug 25;47(2):137-43. Unique Identifier : AIDSLINE /MED97443499; Suh T; Mandell W; Latkin C; Kim J; Department of Mental Hygiene, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, MD 21205, USA. tsuh@kihm.re.kr; As an alternative approach to individually-focused understanding of HIV risk behavior, this study explored the relationship between social network characteristics and HIV-risk injecting behaviors. Subjects were 499 inner-city injection drug users IDUs) recruited from the streets of Baltimore, Maryland. Analysis of str
Validity of three measures of antisociality in predicting HIV risk behaviors in methadone-maintenance patients.: Drug Alcohol Depend. 1997 Aug 25;47(2):99-107. Unique Identifier : AIDSLINE /MED97443495; Tourian K; Alterman A; Metzger D; Rutherford M; Cacciola JS; McKay JR; University of Pennsylvania, Treatment Research Center, Philadelphia; 19104, USA.; Most opiate users are injection drug users (IDUs). A significant percentage of IDUs have antisocial personality disorder (APD). APD has been found by some researchers to be an additional risk factor for human immunodeficiency virus (HIV) infection in IDUs. The present study evaluated the association of sociodemographi
[More successful therapy of CMV retinitis in AIDS patients news)]: Dtsch Med Wochenschr. 1997 Sep 19;122(38):A23. Unique Identifier : AIDSLINE /MED98030188
[HIV--transmission by kissing]: Dtsch Med Wochenschr. 1997 Sep 26;122(39):A8. Unique Identifier : AIDSLINE /MED98037375; Schattenfroh S
[Meningitis after acute Borrelia burgdorferi infection in HIV infection]: Dtsch Med Wochenschr. 1997 Sep 26;122(39):1178-80. Unique Identifier : AIDSLINE /MED98011211; Dudle G; Opravil M; Luthy R; Weber R; Abteilung Infektionskrankheiten und Spitalhygiene, Universitatsspital; Zurich.; HISTORY AND CLINICAL FINDINGS: A 39-year-old HIV positive patient developed myalgia, headache and cough 4 weeks after a tick bite. His temperature was 37.4 degrees C and a circular pale erythema was noted over the left lower leg. INVESTIGATIONS: C-reactive protein was raised to 120 mg/l, white blood cell count was 586
[Medical students still fail to know about the epidemiology of HIV (letter)]: Dtsch Med Wochenschr. 1997 Sep 26;122(39):1197-8. Unique Identifier : AIDSLINE /MED98011216; Klewer J; Seelbach H; Kugler J
[More and more of HIV non-B infections in Germany, too]: Dtsch Med Wochenschr. 1997 Oct 2;122(40):A9. Unique Identifier : AIDSLINE /MED98012819; Apel B
[HIV-therapy: as early and as intensive as possible (news)]: Dtsch Med Wochenschr. 1997 Oct 10;122(41):A27. Unique Identifier : AIDSLINE /MED98027734
[Initial administration of a protease inhibitor delays the progression of AIDS by half time]: Dtsch Med Wochenschr. 1997 Oct 17;122(42):A27. Unique Identifier : AIDSLINE /MED98027745
Immunotoxicity of 2',3'-dideoxyinosine in female B6C3F1 mice.: Drug Chem Toxicol. 1997 Aug;20(3):189-228. Unique Identifier : AIDSLINE /MED97437744; Phillips KE; McCay JA; Brown RD; Musgrove DL; Meade BJ; Butterworth LF; Wilson S; White KL Jr; Munson AE; Department of Pharmacology & Toxicology, Medical College of; Virginia/Virginia Commonwealth University, Richmond 23298-0613, USA.; 2 ,3 -dideoxyinosine (ddI) is one of several purine analogues used for the treatment of HIV and the acquired immunodeficiency syndrome (AIDS). These nucleoside analogues are promising in their inhibition of viral reverse transcriptase and termination of DNA synthesis. However, each of these drugs has toxicity associat
Apoptosis: clinical relevance and pharmacological manipulation.: Drugs. 1997 Oct;54(4):511-32. Unique Identifier : AIDSLINE /MED97479878; Thatte U; Dahanukar S; Department of Pharmacology, Seth GS Medical College, Mumbai, India.; anand.rao@gems.vsnl.net.in; Apoptosis, often synonymously used with the term programmed cell death , is an active, genetically controlled process that removes unwanted or damaged cells. Suppression, overexpression or mutation of a number of genes which orchestrate the apoptotic process are associated with disease. The diseases in which apoptosi
Recurrent respiratory tract infections in paediatric patients.: Drugs. 1997;54 Suppl 1:1-4. Unique Identifier : AIDSLINE /MED98021172; Bellanti JA; International Center for Interdisciplinary Studies of Immunology,; Georgetown University School of Medicine, Washington, DC, USA.; Paediatric respiratory tract infections are one of the most common reasons for physician visits and hospitalisation, and are associated with significant morbidity and mortality. The role of physicians and other healthcare professionals has expanded from merely treating disease to implementing measures aimed at health
HIV antibody testing in a teaching hospital: policy versus practice.: East Afr Med J. 1997 May;74(5):315-6. Unique Identifier : AIDSLINE /MED97478098; Adu-Sarkodie YA; Department of Clinical Microbiology Komfo Anokye Teaching Hospital,; Kumasi, Ghana.; The cost of HIV antibody testing can be phenomenal. Thus many countries, Ghana included, have adopted policies to guide physicians in making judicious test requests. An analysis of compliance with this policy in a teaching hospital in Ghana, shows that 70% of physician requests meet
Nutritional status of HIV-seropositive subjects in an AIDS clinic in Paris.: Eur J Clin Nutr. 1997 Sep;51(9):637-40. Unique Identifier : AIDSLINE /MED97451116; Niyongabo T; Bouchaud O; Henzel D; Melchior JC; Samb B; Dazza MC; Ruggeri C; Begue JC; Coulaud JP; Larouze B; IMEA/INSERM U13, Hopital Bichat-Claude Bernard, Paris, France.; OBJECTIVE: To measure the prevalence and analyse the characteristics of malnutrition among subjects attending an AIDS outpatient clinic and a day care center, to improve the nutritional management of HIV-infected subjects. DESIGN: Prospective cross-sectional study. SETTING: AIDS clinic in a University Hospital in Pari
Interpersonal perception of the AIDS risk potential of persons of the opposite sex.: Health Psychol. 1997 Sep;16(5):480-6. Unique Identifier : AIDSLINE /MED97448135; Malloy TE; Fisher WA; Albright L; Misovich SJ; Fisher JD; Department of Psychology, Rhode Island College, Providence 02908, USA.; tmalloy@grog.ric.edu; Individuals engage in high rates of AIDS risk behavior, despite awareness that infection is preventable, and use biased decision rules for determining the AIDS risk potential of their own and others behavior. In this laboratory study, 32 male and 32 female university students made judgments of the AIDS risk potential
Effects of a drinking event on behavioral skills and condom attitudes in men: implications for HIV risk from a controlled experiment.: Health Psychol. 1997 Sep;16(5):490-5. Unique Identifier : AIDSLINE /MED97448137; Gordon CM; Carey MP; Carey KB; Department of Psychology, Syracuse University, New York 13244-2340,; USA. cmgordon@mailbox.syr.edu; This study experimentally tested the effects of a drinking event on HIV-related behavioral skills and condom attitudes. Sixty unmarried, heterosexual men were assigned to 1 of 3 conditions sober, placebo, or alcohol). Participants who consumed alcohol demonstrated lower skill to negotiate for condom use relative to so
The HIV-1 5' LTR poly(A) site is inactivated by U1 snRNP interaction with the downstream major splice donor site.: EMBO J. 1997 Sep 15;16(18):5752-63. Unique Identifier : AIDSLINE /MED97459960; Ashe MP; Pearson LH; Proudfoot NJ; Sir William Dunn School of Pathology, Oxford University, South Parks; Road, Oxford OX1 3RE, UK.; The inactivity of the 5 long terminal repeat (LTR) poly(A) site immediately downstream of the cap site maximizes the production of HIV-1 transcripts. In this paper, we demonstrate that this inactivity is mediated by the interaction of the U1 snRNP with the major splice donor site (MSD). The inhibition of the HIV-1 po
Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.: Eur J Biochem. 1997 Sep 1;248(2):313-22. Unique Identifier : AIDSLINE /MED98004269; Lange-Savage G; Berchtold H; Liesum A; Budt KH; Peyman A; Knolle J; Sedlacek J; Fabry M; Hilgenfeld R; Hoechst AG, Central Pharma Research, Frankfurt, Germany.; Human immunodeficiency virus 1 (HIV-1) protease is a prime target in the search for drugs to combat the AIDS virus. The enzyme functions as a C2-symmetric dimer, cleaving the gag and gag-pol viral polyproteins at distinct sites. The possession of a twofold axis passing through the active site, has led to the design of
Studies on the NusB protein of Escherichia coli--expression and determination of secondary-structure elements by multinuclear NMR spectroscopy.: Eur J Biochem. 1997 Sep 1;248(2):338-46. Unique Identifier : AIDSLINE /MED98004272; Berglechner F; Richter G; Fischer M; Bacher A; Gschwind RM; Huenges M; Gemmecker G; Kessler H; Lehrstuhl fur Organische Chemie und Biochemie, Technische Universitat; Munchen, Garching, Germany.; The product of the nusB gene of Escherichia coli modulates the efficiency of transcription termination at nut (N utilization) sites of various bacterial and bacteriophage lambda genes. Similar control mechanisms operate in eukaryotic viruses (e.g. human immunodeficiency virus). A recombinant strain of E. coli producin
Current knowledge of Bartonella species.: Eur J Clin Microbiol Infect Dis. 1997 Jul;16(7):487-506. Unique Identifier : AIDSLINE /MED97418379; Maurin M; Birtles R; Raoult D; Unite des Rickettsies, CNRS UPRESA 6020, Universite de la; Mediterrance, Faculte de Medecine, Marseille, France.; Bartonella species are now considered emerging pathogens. Of the 11 currently recognized species, four have been implicated in human disease, although only two have been encountered in Europe. Bartonella quintana infections are now being diagnosed among the urban homeless and deprived, manifesting as trench fever, and
A case of fatal disseminated histoplasmosis of autochthonous origin in an Italian AIDS patient [letter]: Eur J Clin Microbiol Infect Dis. 1997 Jul;16(7):545-6. Unique Identifier : AIDSLINE /MED97418389; Antinori S; Galimberti L; Bonaccorso C; Vago L; Nebuloni M; Esposito R
Detection of Mycobacterium avium-intracellulare in the blood of HIV-infected patients by a commercial polymerase chain reaction kit [letter]: Eur J Clin Microbiol Infect Dis. 1997 Jul;16(7):549-51. Unique Identifier : AIDSLINE /MED97418392; Ninet B; Auckenthaler R; Rohner P; Delaspre O; Hirschel B
Edwardsiella tarda septicemia with cellulitis in a patient with AIDS [letter]: Eur J Clin Microbiol Infect Dis. 1997 Jul;16(7):551-3. Unique Identifier : AIDSLINE /MED97418393; Fournier S; Pialoux G; Feuillie V; Fleury J; Dupont B
Atypical coccidioidomycosis in an AIDS patient successfully treated with fluconazole.: Eur J Clin Microbiol Infect Dis. 1997 Aug;16(8):592-4. Unique Identifier : AIDSLINE /MED97464758; Hernandez JL; Echevarria S; Garcia-Valtuille A; Mazorra F; Salesa R; Department of Internal Medicine, Hospital Marques de Valdecilla,; University of Cantabria, Santander, Spain.; Cervical lymphadenopathy due to Coccidioides immitis occurred as the sole opportunistic infection in a Spanish patient with the acquired immunodeficiency syndrome. Twelve years earlier the patient had lived in the desert regions of the southwestern USA. After an initial course of high doses of fluconazole, the patient
Mixed Candida glabrata and Candida albicans disseminated candidiasis in a heroin addict.: Eur J Clin Microbiol Infect Dis. 1997 Aug;16(8):598-600. Unique Identifier : AIDSLINE /MED97464760; Bougnoux ME; Dupont C; Turner L; Rouveix E; Dorra M; Nicolas-Chanoine MH; Department of Microbiology, Hopital Ambroise-Pare, Universite Paris V,; Boulogne-Billancourt, France.; The case of a white-heroin addict who developed disseminated candidiasis following coinfection by Candida glabrata and Candida albicans is reported. Genomic random amplified polymorphic DNA typing suggested that the Candida glabrata blood isolates originated in the oral cavity of the patient. This case strengthens the
Genotypic identification of sequential Candida albicans isolates from AIDS patients by polymerase chain reaction techniques.: Eur J Clin Microbiol Infect Dis. 1997 Aug;16(8):601-5. Unique Identifier : AIDSLINE /MED97464761; Barchiesi F; Di Francesco LF; Compagnucci P; Arzeni D; Cirioni O; Scalise G; Istituto di Malattie Infettive & Medicina Pubblica, Universita degli; Studi di Ancona, Ospedale Umberto Io, Italy.; Random amplification of polymorphic DNA and inter-repeat polymerase chain reaction (IR-PCR) were compared with restriction fragment length polymorphism (RFLP) analysis as methods for DNA typing of Candida albicans. Forty-seven strains of Candida albicans isolated from the oral cavities of five AIDS patients undergoing
Hepatitis C and human immunodeficiency virus infection following ozone autohaemotherapy [letter]: Eur J Clin Microbiol Infect Dis. 1997 Aug;16(8):620. Unique Identifier : AIDSLINE /MED97464766; Daschner FD
Lymphocyte subpopulations in the blood of women with HPV 16 positive and negative cervical cancer.: Eur J Gynaecol Oncol. 1997;18(5):394-6. Unique Identifier : AIDSLINE /MED98018289; Frankowski A; Wiktorowicz K; Kedzia W; Porzba E; Gozdzicka-Jolefiak A; Kedzia H; Institute of Gynaecology and Obstetrics, Medical Academy, Poland.; In this study the morphologic features and subpopulation of lymphocytes in the blood of women with uterine cervical cancer HPV 16 positive and HPV 16 negative was compared. The essential morphological differentiation in two groups of cancer was not found, but a statistically significant increase in CD 19 lymphocytes i
Interleukin-2 receptor beta and gamma chain dysregulation during the inhibition of CD4 T cell activation by human immunodeficiency virus-1 gp120.: Eur J Immunol. 1997 Sep;27(9):2188-94. Unique Identifier : AIDSLINE /MED98000965; Bani L; David D; Fevrier M; Pialoux G; Dupont B; Sugamura K; Theze J; Departement d'Immunologie, Institut Pasteur, Paris, France.; We have observed that CD4 T lymphocytes from human immunodeficiency virus (HIV)-infected patients marginally express interleukin-2 receptor (IL-2R) beta and IL-2R gamma chains which are essential for IL-2 signal transduction. To analyze this observation further, we studied the influence of gp120 on the cell surface ex
Opposite role for interleukin-4 and interferon-gamma on CD30 and lymphocyte activation gene-3 (LAG-3) expression by activated naive T cells.: Eur J Immunol. 1997 Sep;27(9):2239-44. Unique Identifier : AIDSLINE /MED98000972; Annunziato F; Manetti R; Cosmi L; Galli G; Heusser CH; Romagnani S; Maggi E; Istituto di Medicina Interna e Immunoallergologia, University of; Florence, Italy.; Polarized human type 1 and type 2 T helper cells not only produce different sets of cytokines, but they also preferentially express certain activation markers, such as lymphocyte activation gene-3 LAG-3) and CD30, respectively. In this study we have examined the LAG-3 and CD30 expression in relation to the lineage com
T cell repertoire in patients with multiple myeloma and monoclonal gammopathy of undetermined significance: clonal CD8+ T cell expansions are found preferentially in patients with a low tumor burden.: Eur J Immunol. 1997 Sep;27(9):2245-52. Unique Identifier : AIDSLINE /MED98000973; Halapi E; Werner A; Wahlstrom J; Osterborg A; Jeddi-Tehrani M; Yi Q; Janson CH; Wigzell H; Grunewald J; Mellstedt H; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; The T cell receptor (TCR) variable (V) gene repertoire was analyzed in patients with monoclonal gammopathy of undetermined significance (MGUS) (n = 17), multiple myeloma (MM) stage I (n = 16), MM stages II/III (n = 31) and age-matched controls (n = 27) by immunofluorescence and flow cytometry using a panel of mouse mo
Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection.: Eur J Immunol. 1997 Sep;27(9):2279-89. Unique Identifier : AIDSLINE /MED98000977; Ghendler Y; Hussey RE; Witte T; Mizoguchi E; Clayton LK; Bhan AK; Koyasu S; Chang HC; Reinherz EL; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA; 02115, USA. yoseph_ghendler@dfci.harvard.edu; To investigate negative selection events during intrathymic ontogeny, we established T cell receptor (TCR)-transgenic mice [N15tg/RAG-2-/- (H-2b)] expressing a single TCR specific for vesicular stomatitis virus nuclear octapeptide N52-59 (VSV8) in the context of the major histocompatibility complex (MHC) class I molec
Antigen-specific CD8+ T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection.: Eur J Immunol. 1997 Sep;27(9):2310-6. Unique Identifier : AIDSLINE /MED98000981; Cose SC; Jones CM; Wallace ME; Heath WR; Carbone FR; Department of Pathology and Immunology, Monash Medical School,; Melbourne, Australia.; Inoculation with replicating virus leads to an increase in T cell numbers within lymph nodes that drain the site of infection. This increase has been associated with a nonspecific proliferation of bystander cells, with only a minority thought to be directed to the infectious agent. Such an assumption is largely based
Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides.: Eur J Immunol. 1997 Sep;27(9):2323-9. Unique Identifier : AIDSLINE /MED98000983; Sewell AK; Harcourt GC; Goulder PJ; Price DA; Phillips RE; Nuffield Department of Clinical Medicine, John Radcliffe Hospital,; Oxford, GB. asewell@worf.molbiol.ox.ac.uk; Mutations in human immunodeficiency virus (HIV) cluster in cytotoxic T lymphocyte (CTL) epitopes (Phillips, R. E. et al., Nature 1991. 354: 453) and are subject to immune-mediated positive selection (Price, D. A. et al., Proc. Natl. Acad. Sci. USA 1997. 94: 1890). We studied the effects of naturally occurring mutation
Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes.: Eur J Immunol. 1997 Sep;27(9):2330-9. Unique Identifier : AIDSLINE /MED98000984; Trembleau S; Penna G; Gregori S; Gately MK; Adorini L; Roche Milano Ricerche, Milano, Italy.; Nonobese diabetic (NOD) mice develop spontaneous insulin-dependent diabetes mellitus (IDDM), and the pancreas-infiltrating T cells invariably show a Th1 phenotype. We demonstrated here that the interleukin (IL)-12 antagonist (p40)2 can deviate the default Th1 development of naive T cell receptor TCR)-transgenic CD4+ c
Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.: Eur J Immunol. 1997 Sep;27(9):2457-65. Unique Identifier : AIDSLINE /MED98001000; Mazerolles F; Barbat C; Fischer A; INSERM U 429, Hopital Necker-Enfants Maladis, Paris, France.; mazerol@ceylan.necker.fr; Human immunodeficiency virus binds to CD4+ T lymphocyte by the interaction, in part, between its gp120 envelope glycoprotein and the CD4 molecule. We and others have reported that the lipid kinase phosphatidylinositol-3-kinase (PI3-kinase) is associated with the CD4-p56lck complex and can be activated by various CD4 l
Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production.: Eur J Pharmacol. 1997 Jul 23;331(2-3):245-52. Unique Identifier : AIDSLINE /MED97418910; Zidek Z; Holy A; Frankova D; Institute of Pharmacology, Academy of Sciences of the Czech Republic,; Prague. zidekz@biomed.cas.cz; The immunomodulatory properties of (R)-enantiomer of 9-(2-phoshonomethoxypropyl)adenine ((R)-PMPA), one of the most potent acyclic nucleotide analogs effective against human immunodeficiency virus (HIV), were investigated under in vitro conditions using murine peritoneal macrophages. Remaining without influence on int
Specific immunosuppression of corneal allograft rejection by combination of anti-VLA-4 and anti-LFA-1 monoclonal antibodies in mice.: Exp Eye Res. 1997 Jul;65(1):89-98. Unique Identifier : AIDSLINE /MED97383206; Hori J; Isobe M; Yamagami S; Mizuochi T; Tsuru T; Department of Ophthalmology, University of Tokyo Faculty of Medicine,; Tokyo, Japan.; It has been reported that allograft rejection is mediated by a variety of adhesion molecules. Using a corneal allograft model in mice, we studied the role of very late antigen (VLA)-4 and leukocyte function-associated antigen (LFA)-1 adhesion molecules in corneal allograft rejection and the effects of monoclonal antib
[Classical Kaposi sarcoma and volcanic soil in southern Italy: a case-control study]: Epidemiol Prev. 1997 Apr-Jun;21(2):114-7. Unique Identifier : AIDSLINE /MED97432209; Montella M; Franceschi S; Geddes da Filicaia M; De Macro M; Arniani S; Balzi D; Delfino M; Iannuzzo M; Buonanno M; Satriano RA; Servizio Epidemiologia, 1st. Naz Tumori, Napoli.; We tested the hypothesis of a relationship between Kaposi s sarcoma (KS) and volcanic soil by means of a case-control study based on 70 cases of classic KS and 280 hospital controls from the Campania region, an area of active volcanism in the South of Italy . Birth and residence in v
Analysis of myeloid-associated genes in human hematopoietic progenitor cells.: Exp Hematol. 1997 Oct;25(11):1158-66. Unique Identifier : AIDSLINE /MED97467112; Bello-Fernandez C; Matyash M; Strobl H; Scheinecker C; Knapp W; Institute of Immunology-Vienna International Research Cooperation; Center at SFI, University of Vienna, Austria.; The distribution of myeloid lineage-associated cytokine receptors and lysosomal proteins was analyzed in human CD34+ cord blood cell (CB) subsets at different stages of myeloid commitment by reverse-transcriptase polymerase chain reaction (RT-PCR). The highly specific granulomonocyte-associated lysosomal proteins myel
Use of hematopoietic cytokines to accelerate the recovery of the immune system in irradiated mice.: Exp Hematol. 1997 Oct;25(11):1167-71. Unique Identifier : AIDSLINE /MED97467113; Frasca D; Guidi F; Arbitrio M; Pioli C; Leter G; Spano M; Doria G; Laboratory of Immunology, AMB-PRO-TOSS, ENEA CR Casaccia, Rome, Italy.; In our previous studies aimed at designing appropriate strategies to accelerate recovery of the immune system after irradiation, we found that the hematopoietic cytokine recombinant murine (rmu) interleukin (IL)-3 was able to induce differentiation and growth of thymocytes and splenic T and B lymphocytes in mice expos
Human T lymphotropic virus-type I Tax induction of CD21/Epstein-Barr virus receptor expression on T cells and its significance in leukemogenesis of adult T cell leukemia.: Exp Hematol. 1997 Nov;25(12):1246-52. Unique Identifier : AIDSLINE /MED98019000; Ohtsubo H; Arima N; Matsushita K; Hidaka S; Fujiwara H; Arimura K; Kukita T; Fukumori J; Matsumoto T; Eizuru Y; Tanaka H; The First Department of Internal Medicine, Center for Chronic Viral; Disease, Faculty of Medicine, Kagoshima University, Japan.; CD21, which is expressed on B cells, is also expressed on human T lymphotropic virus-type I (HTLV-I)-infected T cell lines. CD21 also serves as a receptor of Epstein-Barr virus (EBV). We evaluated the mechanism of CD21 induction on HTLV-I-infected T cells and its clinical significance in the leukemogenesis of adult T
Acute renal failure and proximal tubule lesions after trichosanthin injection in rats.: Exp Mol Pathol. 1997 Apr;64(2):78-89. Unique Identifier : AIDSLINE /MED97462316; Tang NL; Chan WL; Ke YO; Mak MK; Lai FM; Tam SC; Department of Physiology, Chinese University of Hong Kong, Hong Kong.; The structural basis of the recently recognized renal impairment after infusion of trichosanthin (TCS), a type I ribosome inactivating protein, is uncertain, but functionally it appears to be related to a lesion in the renal tubules. In this study, renal dysfunction in experimental rats was induced by a single dose of
Detection of BK polyomavirus genotypes in healthy and HIV-positive children.: Eur J Epidemiol. 1997 Sep;13(6):653-7. Unique Identifier : AIDSLINE /MED97464390; Di Taranto C; Pietropaolo V; Orsi GB; Jin L; Sinibaldi L; Degener AM; Institute of Microbiology, University La Sapienza, Rome, Italy.; Urine samples from 211 community children (3-7 years age), from 33 HIV type-1 infected children and from 56 HIV-negative children were collected and analyzed for the presence of BK virus (BKV) DNA by PCR. PCR amplifications were carried out using primers specific for the BKV structural region VP1. We also investigated
Sexual initiation with older male partners and subsequent HIV risk behavior among female adolescents.: Fam Plann Perspect. 1997 Sep-Oct;29(5):212-4. Unique Identifier : AIDSLINE /MED97464784; Miller KS; Clark LF; Moore JS; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, USA.; Data from a 1993-1994 survey of 150 black and Hispanic teenagers were used to examine differences in HIV risk-related behavior between young women who have a first sexual partner three or more years older than themselves and those whose first partner is their age. Compared with teenagers whose first partner had been r
HIV-1 envelope protein, gp120, has no effects on inositol phosphate production and metabolism in the Jurkat T-cell line either in the presence or absence of receptor stimulation.: FEBS Lett. 1997 Aug 11;413(1):75-80. Unique Identifier : AIDSLINE /MED97431615; Sumner MT; Shears SB; Laboratory of Signal Transduction, National Institute of Environmental; Health Sciences, National Institutes of Health, Research Triangle; Park, NC 27709, USA. sumner1@niehs.nih.gov; We have used HPLC techniques to investigate the effects of gp120 upon inositol phosphate turnover in Jurkat E6-1 CD4+ T-cells, to pursue previous reports that this viral coat protein: (a) inhibits receptor-activated inositol phosphate release; (b) stimulates basal inositol phosphate release; (c) inhibits inositol poly
Rescue of a neutralizing anti-viral antibody fragment from an intracellular polyclonal repertoire expressed in mammalian cells.: FEBS Lett. 1997 Sep 15;414(3):537-40. Unique Identifier : AIDSLINE /MED97462803; Gargano N; Cattaneo A; MRC Laboratory of Molecular Biology, Cambridge, UK.; The intracellular expression of recombinant antibodies in mammalian cells is an experimental strategy to inhibit in vivo the function of selected molecules. However, one limitation of this technology is represented by the unpredictable behaviour of antibodies, under conditions of intracellular expression. For this rea
HIV-1 Nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas).: FEBS Lett. 1997 Sep 15;414(3):603-6. Unique Identifier : AIDSLINE /MED97462818; Okada H; Takei R; Tashiro M; Department of Virology 1, National Institute of Infectious Diseases,; Tokyo, Japan.; The Nef protein of HIV-1 binds to uninfected CD4+T lymphocytes and induces apoptotic cytolysis of the cells. We examined several human blood cell lines and peripheral blood mononuclear cells PBMCs) for Nef-induced apoptotic cell death. Soluble Nef protein was shown to bind to the cell surface of not only CD4+T cells b
Regulation of ocular immune responses.: Eye. 1997;11 ( Pt 2):171-5. Unique Identifier : AIDSLINE /MED98010121; Streilein JW; Schepens Eye Research Institute, Harvard Medical School, Boston, MA; 02114, USA.; The existence of immune privilege in numerous tissues and organs, including the eye, has been re-emphasised during the past few years, and experimental studies have begun to unravel the multiple mechanisms, both passive and active, that make privilege possible. In this review, recent evidence bearing on the factors re
T cell mechanisms in experimental autoimmune uveoretinitis: susceptibility is a function of the cytokine response profile.: Eye. 1997;11 ( Pt 2):209-12. Unique Identifier : AIDSLINE /MED98010127; Caspi RR; Sun B; Agarwal RK; Silver PB; Rizzo LV; Chan CC; Wiggert B; Wilder RL; Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD; 20892-1858, USA.; This study addresses the question whether susceptibility versus resistance to experimental autoimmune uveoretinitis (EAU) is connected to a Th1-type (interferon-gamma high, interleukin-4 low), versus a Th2-type (IFN-gamma low, IL-4 high) response. Primed lymph node cells of susceptible Lewis rats produced IFN-gamma in
CD8 cytotoxic T-cell clone rapidly transfers autoimmune diabetes in very young NOD and MHC class I-compatible scid mice.: Diabetologia. 1997 Sep;40(9):1044-52. Unique Identifier : AIDSLINE /MED97445356; Yoneda R; Yokono K; Nagata M; Tominaga Y; Moriyama H; Tsukamoto K; Miki M; Okamoto N; Yasuda H; Amano K; Kasuga M; Second Department of Internal Medicine, Kobe University School of; Medicine, Japan.; A CD8 T-cell clone (YNK1.3) generated from acutely diabetic NOD mouse islets, showed proliferation and cytotoxicity when challenged with NOD and BALB/c islet cells and NOD-derived insulinoma cells. When 1-2 x 10(7) YNK1.3 cells were administered to 7-10-day-old NOD mice, the cells transferred overt diabetes very rapid
[Cardiac complications in HIV infections]: G Ital Cardiol. 1997 Sep;27(9):917-24. Unique Identifier : AIDSLINE /MED98018345; Cecchi E; Parrini I; Chinaglia A; Pomari F; Dal Conte I; Lipani F; Preziosi C; Zucco S; Brusasco G; Trinchero R; Divisione di Cardiologia, Ospedale Maria Vittoria, Torino.; Cardiological involvement in HIV infection is relatively rare but it presents important clinical aspects that are still open questions. We report our experience with HIV patients who underwent cardiological evaluation, Doppler echocardiography and follow-up. MATERIAL AND METHOD: We selected 127 patients (9%) on the ba
Taking a new TAK on tat transactivation [comment]: Genes Dev. 1997 Oct 15;11(20):2593-9. Unique Identifier : AIDSLINE /MED97477367; Jones KA; The Salk Institute for Biological Studies, La Jolla, California; 92037-1099 USA. jones@salk.edu
Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro.: Genes Dev. 1997 Oct 15;11(20):2622-32. Unique Identifier : AIDSLINE /MED97477369; Zhu Y; Pe'ery T; Peng J; Ramanathan Y; Marshall N; Marshall T; Amendt B; Mathews MB; Price DH; Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242; USA.; P-TEFb is a key regulator of the process controlling the processivity of RNA polymerase II and possesses a kinase activity that can phosphorylate the carboxy-terminal domain of the largest subunit of RNA polymerase II. Here we report the cloning of the small subunit of Drosophila P-TEFb and the finding that it encodes
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro.: Genes Dev. 1997 Oct 15;11(20):2633-44. Unique Identifier : AIDSLINE /MED97477370; Mancebo HS; Lee G; Flygare J; Tomassini J; Luu P; Zhu Y; Peng J; Blau C; Hazuda D; Price D; Flores O; Tularik, Inc., South San Francisco, California 94080 USA.; To identify novel inhibitors of transcriptional activation by the HIV Tat protein, we used a combination of in vitro and in vivo Tat-dependent transcription assays to screen >100,000 compounds. All compounds identified blocked Tat-dependent stimulation of transcriptional elongation. Analysis of a panel of structurally
The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.: Genes Dev. 1997 Oct 15;11(20):2645-57. Unique Identifier : AIDSLINE /MED97477371; Cujec TP; Okamoto H; Fujinaga K; Meyer J; Chamberlin H; Morgan DO; Peterlin BM; Howard Hughes Medical Institute, Department of Medicine, University of; California at San Francisco, San Franscisco, California USA.; The human immunodeficiency virus encodes the transcriptional transactivator Tat, which binds to the transactivation response TAR) RNA stem-loop in the viral long terminal repeat (LTR) and increases rates of elongation rather than initiation of transcription by RNA polymerase II (Pol II). In this study, we demonstrate
Developmental expression analysis of the 1731 retrotransposon reveals an enhancement of Gag-Pol frameshifting in males of Drosophila melanogaster.: Gene. 1997 Sep 1;196(1-2):83-93. Unique Identifier : AIDSLINE /MED97464053; Haoudi A; Rachidi M; Kim MH; Champion S; Best-Belpomme M; Maisonhaute C; Laboratoire de Genetique Cellulaire et Moleculaire, UA 1135 CNRS,; Universite Pierre and Marie Curie, Paris, France.; Extensive analyses of Drosophila melanogaster retrotransposon transcriptions in cultured cells or during development have been reported, but little is known about their translation during the development of the fly. Analysis of the translational products of the 1731 Drosophila melanogaster retrotransposon in Kc Drosop
The 5'-upstream region of the rat phospholipase C-beta 3 gene contains two critical Sp1 sites and an HIV Inr-like element.: Gene. 1997 Sep 15;197(1-2):19-28. Unique Identifier : AIDSLINE /MED97473492; Kang JS; Lee HB; Rhee SG; Park K; Yoo OJ; Department of Biological Sciences, Korea Advanced Institute of Science; and Technology, Taejon, South Korea.; The 5 -upstream region of the rat phospholipase C-beta 3 gene PLC-beta 3) has been cloned and characterized. Sequence analysis of the 5 -upstream region showed that it contains a GC-rich region (-166 to +1: 79%) and multiple binding sites for the transcription factors Sp1, AP-1 and AP-2, but does not contain a canonic
Chronic diarrhoea in AIDS [letter; comment]: Gut. 1997 Sep;41(3):418. Unique Identifier : AIDSLINE /MED98022352; Hicks S; Phillips AD
[The enigma of Kaposi's sarcoma--the end of the matter? editorial)]: Harefuah. 1997 Jul;133(1-2):22-4. Unique Identifier : AIDSLINE /MED97473189; Ben-Amitai D
[HIV infected patient wanted to hold physician responsible. He was acquitted--what belongs in patient records]: Fortschr Med. 1997 Sep 10;115(25):55-6. Unique Identifier : AIDSLINE /MED97469811; Sautter R
Thymoma associated with CD4+ lymphopenia, cytomegalovirus infection, and Kaposi's sarcoma.: Hum Pathol. 1997 Oct;28(10):1211-3. Unique Identifier : AIDSLINE /MED98001495; Moysset I; Lloreta J; Miguel A; Vadell C; Ribalta T; Estrach T; Serrano S; Department of Pathology, Hospital Universitari del Mar, Autonomous; University of Barcelona, Spain.; A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi s sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endothelial cells. It is known that KS has a high
Production and characterization of monoclonal antibodies to human interleukin-12.: Hybridoma. 1997 Aug;16(4):363-9. Unique Identifier : AIDSLINE /MED97455044; Carter RW; Patel PM; Stanley AJ; Ingham E; Wadhwa M; Bird C; Thorpe R; Selby PJ; Banks RE; ICRF Cancer Medicine Research Unit, St James's University Hospital,; Leeds, UK.; Interleukin-12 is a cytokine that plays a central role in mediating cell mediated immunity via enhancement of a TH1 cell response. IL-12, unusually for a cytokine, has a heterodimeric structure made up of 35 kDa and 40 kDa subunits. The aim of this study was to produce and characterize monoclonal antibodies to recombi
Knowledge generation for the HIV-affected family.: Image J Nurs Sch. 1997;29(3):269-74. Unique Identifier : AIDSLINE /MED98021305; Brown MA; Department of Family and Child Nursing, University of Washington,; Seattle 98195, USA.; PURPOSE: To examine the current literature about HIV-affected families in regard to knowledge development and priorities for future research. SIGNIFICANCE: The current view of HIV focuses largely on HIV-infected individuals. There is a paucity of relevant research and a need to make explicit the priorities for knowled
Caring for an AIDS patient.: Imprint. 1996 Sep;43(4):47, 56. Unique Identifier : AIDSLINE /MED97357719; Storms I; Florida Atlantic University, Boca Raton, USA.
An essential role for endogenous interferon-gamma in the generation of protective T cells against Mycobacterium bovis BCG in mice.: Immunology. 1997 Aug;91(4):529-35. Unique Identifier : AIDSLINE /MED98018496; Yang J; Mitsuyama M; Department of Bacteriology, Niigata University School of Medicine,; Japan.; Protective CD4+ T cells against Mycobacterium bovis bacillus Calmette-Guerin (BCG), which are characterized by the ability to produce interferon-gamma (IFN-gamma), could be induced by immunization of mice with viable BCG but not with killed BCG. A high level of IFN-gamma mRNA was observed when normal spleen cells were
Massive production of Th2 cytokines by human CD4+ effector T cells transiently expressing the natural killer cell marker CD57/HNK1.: Immunology. 1997 Aug;91(4):541-7. Unique Identifier : AIDSLINE /MED98018498; Brinkmann V; Kristofic C; Department of Asthma/Allergy Research, Ciba-Geigy Ltd, Basel,; Switzerland.; We have reported previously that uncommitted human CD4+ CD45RO- T cells default to the T-helper type 1 (Th1) pathway, if they are costimulated by anti-CD3 plus anti-CD28 monoclonal antibodies mAb). In contrast, 5% of the uncommitted T cells differentiate into Th2 cells, if they are stimulated by anti-CD28 plus interle
Recruitment of multiple V beta genes in the TCR repertoire against a single pathogenic thyroglobulin epitope.: Immunology. 1997 Aug;91(4):623-7. Unique Identifier : AIDSLINE /MED98018510; Rao VP; Russell RS; Carayanniotis G; Division of Endocrinology, Faculty of Medicine, Memorial University of; Newfoundland, St John's, Canada.; In autoimmune thyroid disease, the question whether thyroid-infiltrating, autoreactive T cells are derived from a polyclonal or oligoclonal subset has been the subject of considerable debate. In this report, we have examined the T-cell receptor (TCR) V beta profile of mouse clonal T cells responding to a single thyroi
Mannan-binding lectin serum concentrations in HIV-infected patients are influenced by the stage of disease.: Immunol Lett. 1997 Aug;58(3):171-5. Unique Identifier : AIDSLINE /MED97438932; Prohaszka Z; Thiel S; Ujhelyi E; Szlavik J; Banhegyi D; Fust G; 3rd Department of Medicine, Semmelweis Medical University, Budapest,; Hungary.; Serum concentrations of mannan-binding lectin (MBL) were determined in the sera of 67 HIV-seropositive patients in different stages of HIV disease and in the sera of 75 HIV-seronegative healthy individuals. In the asymptomatic (AS) HIV-infected persons MBL concentrations were found to be significantly (P
Increasing trend of HIV seroprevalence among pulmonary tuberculosis patients in Pune, India.: Indian J Med Res. 1997 Sep;106:207-11. Unique Identifier : AIDSLINE /MED98017965; Paranjape RS; Tripathy SP; Menon PA; Mehendale SM; Khatavkar P; Joshi DR; Patil U; Gadkari DA; Rodrigues JJ; National AIDS Research Institute, Pune.; A total of 4618 tuberculosis patients attending the TB clinic at the Sassoon General Hospitals, Pune between 1991 and 1996 were screened for anti-HIV antibodies. Of these 694 were found reactive in enzyme immuno assay (EIA) and 624 were further confirmed by a second test, either rapid EIA or Western blot. HIV-1 reacti
Awareness & knowledge of AIDS & HIV risk among women attending STD clinics in Pune, India.: Indian J Med Res. 1997 Sep;106:212-22. Unique Identifier : AIDSLINE /MED98017966; Mawar N; Mehendale S; Thilakavathi S; Shepherd M; Rodrigues J; Bollinger R; Bentley M; National AIDS Research Institute, Pune, India.; The present study attempts to understand the awareness, knowledge and risk to HIV/AIDS among two groups of women: one reporting sex-work (FSW) and second reporting other work (FOW) from two clinics in Pune. The patients are screened for HIV and enrolled in the study. This paper includes 711 women covered between May 1
Hepatitis B kills more than AIDS [news]: Indian J Med Sci. 1997 Feb;51(2):58. Unique Identifier : AIDSLINE /MED98017345
HIV associated chronic atypical osteomyelitis by mycobacterium fortuitum--Chelonae group--a case report.: Indian J Med Sci. 1997 May;51(5):161-3. Unique Identifier : AIDSLINE /MED98017354; Gadre DV; Deptt. of Microbiology UCMS, Delhi.; In developing countries where tuberculosis is endemic, the HIV patients have tuberculosis as one of the major opportunistic infections. Commonly M. tuberculosis, M. Avium-intracellular are the causative agents of pulmonary, extra-pulmonary and disseminated infection in AIDS patients. Here is a report of a 32 year old
HIV and breastfeeding--an alternative [letter]: Indian Pediatr. 1997 May;34(5):453-6. Unique Identifier : AIDSLINE /MED97473263; Selvan R
Nitric oxide regulates clonal expansion and activation-induced cell death triggered by staphylococcal enterotoxin B.: Infect Immun. 1997 Oct;65(10):4030-7. Unique Identifier : AIDSLINE /MED97461322; Bras A; Rodriguez-Borlado L; Gonzalez-Garcia A; Martinez-A C; Department of Immunology and Oncology, National Center for; Biotechnology, CSIC, Universidad Autonoma, Cantoblanco Campus, Madrid,; Spain. abras@cnb.uam.es; Increased interest has recently been focused on nitric oxide (NO) due to its several biological roles. Apart from being a potential antimicrobial defense and a mediator of autoimmune diseases, NO also appears to be a strong mediator of T-cell responses. In this report, we have characterized the effect of NO on T-cell
Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria.: Infect Immun. 1997 Oct;65(10):4090-3. Unique Identifier : AIDSLINE /MED97461331; Hviid L; Kurtzhals JA; Goka BQ; Oliver-Commey JO; Nkrumah FK; Theander TG; Center for Medical Parasitology, Copenhagen University Hospital; Rigshospitalet), University of Copenhagen, Denmark. lhcmp@rh.dk; Frequencies and absolute numbers of peripheral T-cell subsets were monitored closely following acute Plasmodium falciparum malaria in 22 Ghanaian children from an area of hyperendemicity for seasonal malaria transmission. The children presented with cerebral or uncomplicated malaria (CM or UM, respectively) or with se
Lipopeptides of Borrelia burgdorferi outer surface proteins induce Th1 phenotype development in alphabeta T-cell receptor transgenic mice.: Infect Immun. 1997 Oct;65(10):4094-9. Unique Identifier : AIDSLINE /MED97461332; Infante-Duarte C; Kamradt T; Deutsches Rheuma Forschungszentrum, Berlin, Germany.; Induction of the appropriate T helper cell (Th) subset is crucial for the resolution of infectious diseases and the prevention of immunopathology. Some pathogens preferentially induce Th1 or Th2 responses. How microorganisms influence Th phenotype development is unknown. We asked if Borrelia burgdorferi, the spirochet
Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa.: Infect Immun. 1997 Oct;65(10):4229-35. Unique Identifier : AIDSLINE /MED97461350; Haeberle HA; Kubin M; Bamford KB; Garofalo R; Graham DY; El-Zaatari F; Karttunen R; Crowe SE; Reyes VE; Ernst PB; Department of Pediatrics, University of Texas Medical Branch,; Galveston 77555-0366, USA.; The objective of these experiments was to examine the ability of Helicobacter pylori to stimulate interleukin-10 (IL-10) or IL-12 and select for either Th1 or Th2 cells. Gastric biopsy specimens were collected from patients who were categorized with respect to the presence of H. pylori and gastric disease as well as t
In vitro modulation of proliferation and cytokine production by human peripheral blood mononuclear cells from subjects with various forms of coccidioidomycosis.: Infect Immun. 1997 Nov;65(11):4483-7. Unique Identifier : AIDSLINE /MED98013072; Ampel NM; Christian L; Department of Medicine, University of Arizona College of Medicine,; Tucson Veterans Affairs Medical Center, 85723, USA.; nampel@u.arizona.edu; Using peripheral blood mononuclear cells (PBMC) from individuals with or without coccidioidal delayed-type hypersensitivity (DTH), we examined and attempted to modulate the in vitro responses of PBMC from various donors to the coccidioidal antigen toluene spherule lysate (TSL). Among healthy DTH-positive donors, 100 n
Th1 response in Salmonella typhimurium-infected mice with a high or low rate of bacterial clearance.: Infect Immun. 1997 Nov;65(11):4509-14. Unique Identifier : AIDSLINE /MED98013076; Pie S; Truffa-Bachi P; Pla M; Nauciel C; Laboratoire de Microbiologie, Faculte de Medecine de Paris-Ouest,; Universite Paris, Garches, France.; Previous studies have shown that the capacity to clear an attenuated strain of Salmonella typhimurium after the second week of infection varies widely among mouse strains. Bacterial clearance is mediated by CD4+ T cells and is regulated in part by the H-2 complex. The aim of the present study was to compare the patter
Immunization with heat-killed Mycobacterium vaccae stimulates CD8+ cytotoxic T cells specific for macrophages infected with Mycobacterium tuberculosis.: Infect Immun. 1997 Nov;65(11):4525-30. Unique Identifier : AIDSLINE /MED98013078; Skinner MA; Yuan S; Prestidge R; Chuk D; Watson JD; Tan PL; Genesis Research & Development Corporation Limited, Auckland, New; Zealand.; Immune responses to Mycobacterium tuberculosis are analyzed in mice which have been immunized with Mycobacterium vaccae to examine novel ways of altering protective immunity against M. tuberculosis. The spleen cells of mice immunized with M. vaccae proliferate and secrete gamma interferon (IFN-gamma) in response to ch
Salmonellae activate tumor necrosis factor alpha production in a human promonocytic cell line via a released polypeptide.: Infect Immun. 1997 Nov;65(11):4624-33. Unique Identifier : AIDSLINE /MED98013092; Ciacci-Woolwine F; Kucera LS; Richardson SH; Iyer NP; Mizel SB; Department of Microbiology and Immunology, Wake Forest University; Medical Center, Winston-Salem, North Carolina 27157, USA.; Invasive strains of Salmonella spp. cause both systemic and localized infections in humans. The ability to resist infection and some aspects of the tissue pathology associated with the presence of Salmonella in the gastrointestinal tract have been shown to be mediated in part by the induction of tumor necrosis factor
Effect of CMV serology and CMV disease on AIDS morbidity and mortality [letter]: Infection. 1997 Jul-Aug;25(4):255. Unique Identifier : AIDSLINE /MED97411290; Laing RB; Brettle RP; Leen CL
Tuberculosis and HIV infection: a review.: Infection. 1997 Sep-Oct;25(5):274-80. Unique Identifier : AIDSLINE /MED97475348; Schurmann D; Nightingale SD; Bergmann F; Ruf B; II. Medizinische Klinik (Infektiologie), Virchow-Klinikum,; Humboldt-Universitat zu Berlin, Germany.
HHV-8 in PBMC and Kaposi's sarcoma activity [letter]: Infection. 1997 Sep-Oct;25(5):326. Unique Identifier : AIDSLINE /MED97475361; Poggi C; Lafeuillade A; Profizi N; Poizot-Martin I
Characterization of antigenic peptide epitopes by reverse immunology: induction of cytotoxic T lymphocytes specific for exogenous peptide only [letter]: Int J Cancer. 1997 Sep 4;72(5):912-5. Unique Identifier : AIDSLINE /MED97456299; Tanzarella S; Fleischhauer K; van Endert P; Bordignon C; Traversari C
Stimulation of CD8+ T cell responses to MAGE-3 and Melan A/MART-1 by immunization to a polyvalent melanoma vaccine.: Int J Cancer. 1997 Sep 17;72(6):972-6. Unique Identifier : AIDSLINE /MED98021353; Reynolds SR; Oratz R; Shapiro RL; Hao P; Yun Z; Fotino M; Vukmanovic S; Bystryn JC; Ronald O. Perelman Department of Dermatology, New York University; Medical Center, New York 10016, USA.; A critical requirement for cancer vaccines is that they stimulate CD8+ T cell responses. In this study, we tested the ability of a polyvalent melanoma vaccine to induce CD8+ T cell responses to the melanoma associated antigens MAGE-3 and Melan A/MART-1. Fifteen HLA-A2+ patients with resected malignant melanoma were im
HIV infection increases the risk of squamous intra-epithelial lesions in women with HPV infection: an analysis of HPV genotypes. DIANAIDS Collaborative Study Group.: Int J Cancer. 1997 Sep 17;72(6):982-6. Unique Identifier : AIDSLINE /MED98021355; Cappiello G; Garbuglia AR; Salvi R; Rezza G; Giuliani M; Pezzotti P; Suligoi B; Branca M; Migliore G; Formigoni Pomponi D; D'Ubaldo C; Ippolito G; Giacomini G; Benedetto A; Virology Centre, S. Camillo Hospital, Rome, Italy.; We assessed the association between different HPV genotypes, HIV infection, and cervical squamous intra-epithelial lesions (SIL) in 236 women with known HIV serostatus enrolled in a longitudinal multicentric study in Italy . Of these women, 135 were HIV-infected, and were not markedl
Role of the genetic background of rats in infection by HTLV-I and HTLV-II and in the development of associated diseases.: Int J Cancer. 1997 Sep 26;73(1):131-6. Unique Identifier : AIDSLINE /MED97475296; Kazanji M; Ibrahim F; Fiette L; Bomford R; De The G; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur, Paris,; France.; Three aspects of the rat model of HTLV-I/II infection were investigated. (i) The efficacy of HTLV-I-transformed rat cell lines in infecting different strains of rats: WKY and Lewis HTLV-I-transformed cell lines were injected into adult WKY, Lewis and Brown Norway rats, representing
Human herpesvirus-8 (HHV-8) DNA associated with anaplastic large cell lymphoma of the B-cell type in an HIV-1-positive patient [letter]: Int J Cancer. 1997 Oct 9;73(2):303-4. Unique Identifier : AIDSLINE /MED97474435; Buske C; Hannig H; Hiddemann W; Bodemer W
Spontaneous programmed cell death (PCD) process of lymphocytes of FIV-infected cats: pharmacological modulation in vitro.: Int J Immunopharmacol. 1997 Mar;19(3):167-79. Unique Identifier : AIDSLINE /MED97451180; Guiot AL; Rigal D; Chappuis G; Rhone Merieux, Lyon, France.; We previously reported that unstimulated lymphocytes in culture from FIV-infected cats undergo spontaneous apoptosis in vitro as indicated by internucleosomal DNA fragmentation and hypodiploid DNA content of nuclei. Unlike what is reported in HIV-infected individuals, we observed that cell death of cat lymphocytes was
Overdramatization of the burdens on health and social services: a continuing debate in the history of German medicine.: Int J Health Serv. 1997;27(3):559-74. Unique Identifier : AIDSLINE /MED97431189; Schmacke N; Departing from the latest academic research into Nazi medicine in Germany , the author looks at theoretical and ideological concepts in German history that left their mark on the formation of race hygiene. He argues that the overdramatization of the economic burden caused by the sp
Cutaneous disseminated histoplasmosis in AIDS patients in south Florida.: Int J Dermatol. 1997 Aug;36(8):599-603. Unique Identifier : AIDSLINE /MED97470474; Bellman B; Berman B; Sasken H; Kirsner RS; Department of Dermatology and Cutaneous Surgery, University of Miami; School of Medicine, Florida, USA.; BACKGROUND: Histoplasma capsulatum is a dimorphic pathogenic fungus endemic to the Mississippi and Ohio river valleys. In the immunocompetent it causes a self-limited disease, but in the immunocompromised may lead to disseminated disease (disseminated histoplasmosis (DH)). It is one of the opportunistic infections whi
[Risk behaviors related with infection by human immunodeficiency virus among adolescent students in Catalonia]: Gac Sanit. 1997 Mar-Apr;11(2):66-73. Unique Identifier : AIDSLINE /MED97379016; Miret M; Rodes A; Valverde G; Geli M; Casabona J; Centre d'Estudis Epidemiologics sobre la Sida de Catalunya.; OBJECTIVE: To determine the prevalence of HIV-risk behaviours among high-school adolescents, and the association with HIV-related knowledge, attitudes and risk perception. SUBJECTS AND METHODS: In 1992-93 a questionnaire was administered to the students of a convenience sample of 30 classes, previously to an AIDS educ
Disruption of Th1/Th2 cytokine balance by cocaine is mediated by corticosterone.: Immunopharmacology. 1997 Aug;37(1):25-33. Unique Identifier : AIDSLINE /MED97431148; Stanulis ED; Jordan SD; Rosecrans JA; Holsapple MP; Department of Pharmacology and Toxicology, Medical College of; Virginia/Virginia Commonwealth University, Richmond 23298-0613, USA.; Cocaine has been shown to affect immune function through the release of corticosterone. Acute administration of both cocaine and corticosterone produces an enhancement of the T-dependent antibody response to sheep erythrocytes. The T-independent antibody response to DNP-ficoll is not enhanced under identical condition
Time-dose considerations in the treatment of anal cancer.: Int J Radiat Oncol Biol Phys. 1997 Oct 1;39(3):651-7. Unique Identifier : AIDSLINE /MED97475894; Constantinou EC; Daly W; Fung CY; Willett CG; Kaufman DS; DeLaney TF; Department of Radiation Oncology, Boston University Medical; Center/School of Medicine, MA 02118-2393, USA.; PURPOSE: To analyze the impact of patient and treatment parameters in concurrent chemoradiation treatment for anal carcinoma. METHODS AND MATERIALS: Retrospective review of 50 MO anal cancer patients treated from 1984-1994. Most patients received concurrent 5-FU, mitomycin, and radiation. Local control and disease-fre
Surface applicators for high dose rate brachytherapy in AIDS-related Kaposi's sarcoma.: Int J Radiat Oncol Biol Phys. 1997 Oct 1;39(3):769-74. Unique Identifier : AIDSLINE /MED97475910; Evans MD; Yassa M; Podgorsak EB; Roman TN; Schreiner LJ; Souhami L; Department of Radiation Oncology, Royal Victoria Hospital, McGill; University, Montreal, QC, Canada.; PURPOSE: The development of commercially available surface applicators using high dose rate remote afterloading devices has enabled radiotherapy centers to treat selected superficial lesions using a remote afterloading brachytherapy unit. The dosimetric parameters of these applicators, the clinical implementation of t
Scientists to pursue AIDS vaccine based on EIA model [news]: J Am Vet Med Assoc. 1997 Aug 1;211(3):266. Unique Identifier : AIDSLINE /MED97408133
Mycobacterium avium intracellulare infection in patients with HIV or AIDS.: J Antimicrob Chemother. 1997 Aug;40(2):156-60. Unique Identifier : AIDSLINE /MED97445691; Brettle RP; Royal Infirmary NHS Trust, City Hospital, and Department of Medicine,; Royal Infirmary, University of Edinburgh, UK.
Quantitative cytomegalovirus (CMV) antigenaemia during antiviral treatment of AIDS-related CMV disease.: J Antimicrob Chemother. 1997 Aug;40(2):299-302. Unique Identifier : AIDSLINE /MED97445713; Manfredi R; Lazzarotto T; Spezzacatena P; Dal Monte P; Mastroianni A; Coronado OV; Chiodo F; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; In order to assess the value of quantitative measurement of cytomegalovirus ( CMV ) antigenaemia as a marker for the guidance of antiviral chemotherapy in the AIDS setting, 33 patients with CMV complications and showing at leas
Valproic acid treatment of AIDS-related mania [letter]: J Clin Psychiatry. 1997 Sep;58(9):406-7. Unique Identifier : AIDSLINE /MED98018708; RachBeisel JA; Weintraub E
The core domain of HIV-1 integrase recognizes key features of its DNA substrates.: J Biol Chem. 1997 Oct 10;272(41):25809-15. Unique Identifier : AIDSLINE /MED97467380; Gerton JL; Brown PO; Department of Microbiology and Immunology, Stanford University Medical; Center, Stanford, California 94305-5428, USA.; We investigated which features of the substrate specificity of human immunodeficiency virus type 1 (HIV-1) integrase could be assigned to the central domain of the 288-residue HIV-1 integrase protein, composed of amino acids 50-212. This domain contains the active site and shares structural homology with a large famil
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.: J Biol Chem. 1997 Oct 10;272(41):25816-23. Unique Identifier : AIDSLINE /MED97467381; Jin DY; Teramoto H; Giam CZ; Chun RF; Gutkind JS; Jeang KT; Molecular Virology Section, Laboratory of Molecular Microbiology,; NIAID, National Institutes of Health, Bethesda, Maryland 20892-0460,; USA.; Tumor necrosis factor alpha (TNFalpha) has pleiotropic effects on cellular metabolism. One of the signaling paths from the TNFalpha receptor induces a stress-activated protein kinase cascade. Components within this TNFalpha kinase cascade include mitogen-activated protein kinase/extracellular signal-regulated kinase k
Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro.: J Biol Chem. 1997 Oct 10;272(41):25935-40. Unique Identifier : AIDSLINE /MED97467397; Davis DA; Newcomb FM; Starke DW; Ott DE; Mieyal JJ; Yarchoan R; HIV and AIDS Malignancy Branch, NCI, National Institutes of Health,; Bethesda, Maryland 20892, USA.; Previous studies have suggested that the two conserved cysteines of the HIV-1 protease may be involved in regulating protease activity. Here, we examined diglutathionylated wild type protease Cys-67-SSG, Cys-95-SSG) and the monoglutathionylated protease mutants (C67A, Cys-95-SSG and C95A, Cys-67-SSG) as potential subs
Preoperative endovascular embolisation of a vertebral haemangioma.: J Bone Joint Surg Br. 1997 Sep;79(5):808-11. Unique Identifier : AIDSLINE /MED97470581; Ng VW; Clifton A; Moore AJ; Atkinson Morley's Hospital, London, England, UK.; We describe the successful relief of compression of the spinal cord due to a vertebral haemangioma by transcatheter embolisation using cyanoacrylate compounds before operation, and provide a brief review of the literature.
Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.: J Cell Biol. 1997 Nov 3;139(3):651-64. Unique Identifier : AIDSLINE /MED98012198; Signoret N; Oldridge J; Pelchen-Matthews A; Klasse PJ; Tran T; Brass LF; Rosenkilde MM; Schwartz TW; Holmes W; Dallas W; Luther MA; Wells TN; Hoxie JA; Marsh M; Medical Research Council Laboratory for Molecular Cell Biology and; Department of Biochemistry, University College London, London WC1E; 6BT, United Kingdom.; The chemokine receptor CXCR4 is required, together with CD4, for entry by some isolates of HIV-1, particularly those that emerge late in infection. The use of CXCR4 by these viruses likely has profound effects on viral host range and correlates with the evolution of immunodeficiency. Stromal cell-derived factor-1 SDF-
Glucocorticoids and the immune function in the human immunodeficiency virus infection: a study in hypercortisolemic and cortisol-resistant patients.: J Clin Endocrinol Metab. 1997 Oct;82(10):3260-3. Unique Identifier : AIDSLINE /MED97469932; Norbiato G; Bevilacqua M; Vago T; Taddei A; Clerici; Department of Endocrinology, L. Sacco University Hospital, Milan,; Italy.; Immunological studies in human immunodeficiency virus HIV)-positive patients suggest that the disease progression is accompanied by a defective production of type 1 cytokines interleukin-2 ( IL-2 ) and IL-12], an increased production of type 2 cytokines (IL-4, IL-6, and
Abnormalities of apolipoprotein E in the acquired immunodeficiency syndrome.: J Clin Endocrinol Metab. 1997 Nov;82(11):3734-40. Unique Identifier : AIDSLINE /MED98024985; Grunfeld C; Doerrler W; Pang M; Jensen P; Weisgraber KH; Feingold KR; Department of Medicine, University of California, San Francisco, USA.; Given the important role of apolipoprotein E (apoE) in triglyceride metabolism, we analyzed plasma levels and degree of sialylation of apoE in subjects with the acquired immunodeficiency syndrome (AIDS), a disorder accompanied by hypertriglyceridemia. Levels of apoE were significantly increased 1.84-fold) and correlat
Regulation of mucosal immune responses: distinct antigens and antigen presenting cells.: J Clin Immunol. 1997 Sep;17(5):349-53. Unique Identifier : AIDSLINE /MED97468217; Mayer L; Mount Sinai School of Medicine, Division of Clinical Immunology, New; York, New York 10029, USA.
Host-pathogen interactions in the immunopathogenesis of Lyme disease.: J Clin Immunol. 1997 Sep;17(5):354-65. Unique Identifier : AIDSLINE /MED97468218; Hu LT; Klempner MS; Tupper Research Institute, Division of Geographic Medicine and; Infectious Diseases, New England Medical Center, Tufts University; School of Medicine, Boston, Massachusetts 02111, USA.; The immunopathogenesis of Lyme disease is complicated and requires a thorough understanding of the interaction among the causative organism, Borrelia burgdorferi, its tick vector, and its mammalian hosts. In vitro, animal and human studies have shown that the organism is capable of adapting to and utilizing elements f
Altered IL-1 expression and compartmentalization in monocytes from patients with AIDS stimulated with Mycobacterium avium complex.: J Clin Immunol. 1997 Sep;17(5):387-95. Unique Identifier : AIDSLINE /MED97468222; Johnson JL; Shiratsuchi H; Toossi Z; Ellner JJ; Department of Medicine, Case Western Reserve University, University; Hospitals, Cleveland, Ohio, USA.; The pathophysiologic basis for the exuberant intracellular growth of Mycobacterium avium complex (MAC) in AIDS patients is unclear but may relate to altered expression of modulatory cytokines. Interleukin (IL)-1, IL-6, and TNF-alpha expression by monocytes from AIDS patients and healthy subjects (HS) stimulated with i
Suppressed cell-mediated immunity and monocyte and natural killer cell activity following allogeneic immunization of women with spontaneous recurrent abortion.: J Clin Immunol. 1997 Sep;17(5):408-19. Unique Identifier : AIDSLINE /MED97468225; Gafter U; Sredni B; Segal J; Kalechman Y; Department of Nephrology, Rabin Medical Center, Petah-Tikva, Israel.; Spontaneous recurrent abortion (SRA) has been treated by means of immunization with paternal or third-party white blood cells, yet the immunological basis for SRA and for the role of immunization protocols in pregnancy outcome remains controversial. To elucidate this question, nine women with SRA were immunized with p
Numerical and functional characteristics of lymphocyte subsets in centenarians.: J Clin Immunol. 1997 Sep;17(5):420-9. Unique Identifier : AIDSLINE /MED97468226; Miyaji C; Watanabe H; Minagawa M; Toma H; Kawamura T; Nohara Y; Nozaki H; Sato Y; Abo T; Department of Immunology, Niigata University School of Medicine,; Japan.; The immune system in the aged is a very interesting subject for study. In this study, analysis was extended to extrathymic T cells as well as NK cells and conventional T cells (i.e., thymus-derived T cells) in terms of their constitution and function in both healthy and unhealthy centenarians. Middle-aged persons we
FIGO Committee for the Study of Ethical Aspects of Human Reproduction: guidelines on the subject of AIDS and human reproduction.: Hum Reprod. 1997 Aug;12(8):1619. Unique Identifier : AIDSLINE /MED97452367; Schenker JG; FIGO Ethical Committee, Jerusalem, Israel.
Molecular epidemiology of Mycobacterium tuberculosis strains isolated during a 3-year period (1993 to 1995) in Seville, Spain.: J Clin Microbiol. 1997 Oct;35(10):2472-6. Unique Identifier : AIDSLINE /MED97461210; Safi H; Aznar J; Palomares JC; Department of Microbiology, School of Medicine, University of Seville,; Spain.; The genetic polymorphism of Mycobacterium tuberculosis strains isolated in Seville, Spain , was studied by using computer-assisted analysis of the IS6110 fingerprint in order to determine the current situation and to evaluate the human-to-human transmission of this pathogen. One hund
Use of different molecular typing techniques for bacteriological follow-up in a clinical trial with AIDS patients with Mycobacterium avium bacteremia.: J Clin Microbiol. 1997 Oct;35(10):2503-10. Unique Identifier : AIDSLINE /MED97461216; Picardeau M; Varnerot A; Lecompte T; Brel F; May T; Vincent V; Laboratoire de Reference des Mycobacteries, Institut Pasteur, Paris,; France.; One hundred ninety-six Mycobacterium avium isolates from blood samples recovered from 93 AIDS patients for several months were typed by serotyping, by IS1245 restriction fragment length polymorphism (RFLP) analysis and in some cases RFLP analysis with plasmids pVT2 and pLR7 as probes, and by pulsed-field gel electroph
Detection of Pneumocystis carinii DNA in air samples: likely environmental risk to susceptible persons.: J Clin Microbiol. 1997 Oct;35(10):2511-3. Unique Identifier : AIDSLINE /MED97461217; Bartlett MS; Vermund SH; Jacobs R; Durant PJ; Shaw MM; Smith JW; Tang X; Lu JJ; Li B; Jin S; Lee CH; Indiana University School of Medicine, Indianapolis 45202-5120, USA.; mbartlet@indyvax.iupui.edu; The means by which humans acquire Pneumocystis carinii is not well understood. Whether it can be acquired from specific environmental sources or transmitted from person to person has not been determined. This study was designed to detect nucleic acids of P. carinii in air samples from various locations, including P. c
Limited value of PCR for detection of Toxoplasma gondii in blood from human immunodeficiency virus-infected patients.: J Clin Microbiol. 1997 Oct;35(10):2639-41. Unique Identifier : AIDSLINE /MED97461241; Franzen C; Altfeld M; Hegener P; Hartmann P; Arendt G; Jablonowski H; Rockstroh J; Diehl V; Salzberger B; Fatkenheuer G; Department of Internal Medicine I, University of Cologne, Germany.; Caspar.Franzen@Uni-Koeln.DE; Cerebral toxoplasmosis is a common, opportunistic, and often life-threatening disease in HIV-infected patients. Diagnosis is supported mainly by clinical evidence and computerized tomography or magnetic resonance imaging scans, but brain images may share features with other brain diseases occurring in HIV-infected pat
Histoplasma capsulatum sinusitis.: J Clin Microbiol. 1997 Oct;35(10):2649-50. Unique Identifier : AIDSLINE /MED97461243; Butt AA; Carreon J; Section of Infectious Diseases, Louisiana State University Medical; Center, New Orleans 70112, USA. aabutt@bellsouth.net; Sinusitis is commonly reported in patients with AIDS. In addition to the usual bacterial pathogens isolated from immunocompetent patients, sinusitis in patients with AIDS may be caused by a variety of unusual bacteria, viruses, fungi, parasites, and mycobacteria. Histoplasma capsulatum has not typically been associate
Prospective study of human herpesvirus 6, human herpesvirus 7, and cytomegalovirus infections in human immunodeficiency virus-positive patients.: J Clin Microbiol. 1997 Oct;35(10):2657-9. Unique Identifier : AIDSLINE /MED97461246; Fabio G; Knight SN; Kidd IM; Noibi SM; Johnson MA; Emery VC; Griffiths PD; Clark DA; Department of Virology, Royal Free Hospital School of Medicine,; Hampstead, London, United Kingdom.; Blood samples from human immunodeficiency virus (HIV)-positive patients were monitored for cytomegalovirus ( CMV ), human herpesvirus 6 (HHV-6), and HHV-7 by PCR. We detected CMV in 17% of the patients, HHV-6 in 6%, and HHV-7 i
Detection of lipoarabinomannan antibodies in patients with newly acquired tuberculosis and patients with relapse tuberculosis.: J Clin Microbiol. 1997 Oct;35(10):2663-4. Unique Identifier : AIDSLINE /MED97461248; Julian E; Matas L; Ausina V; Luquin M; Departamento de Genetica y Microbiologia, Universidad Autonoma de; Barcelona, Bellaterra, Spain.; A commercially available dot immunoassay that employs the lipoarabinomannan antigen was evaluated for the serologic diagnosis of tuberculosis. The test showed a high specificity 100%); however, its sensitivity was low (18.5%). Antibodies to lipoarabinomannan were detected in the sera of 7 of 71 patients with newly acq
Evaluation of the ESP Culture System II for recovery of mycobacteria from blood specimens collected in isolator tubes.: J Clin Microbiol. 1997 Oct;35(10):2681-2. Unique Identifier : AIDSLINE /MED97461254; Tholcken CA; Huang S; Woods GL; Department of Pathology, University of Texas Medical Branch, Galveston; 77555-0740, USA.; The reliability of the ESP Culture System II (ESP II; AccuMed International, Westlake, Ohio), a continuously monitoring, nonradiometric mycobacterial culture system, for recovery of mycobacteria from sediments of blood collected in an Isolator tube was evaluated by comparing its performance to inoculation of the sedim
DNA typing suggests pigeon droppings as a source of pathogenic Cryptococcus neoformans serotype D.: J Clin Microbiol. 1997 Oct;35(10):2683-5. Unique Identifier : AIDSLINE /MED97461255; Garcia-Hermoso D; Mathoulin-Pelissier S; Couprie B; Ronin O; Dupont B; Dromer F; Unite de Mycologie, Institut Pasteur, Paris, France.; The unusual proportion of serotype D strains of Cryptococcus neoformans infecting patients diagnosed with cryptococcosis in some parts of France prompted the analysis of DNA fingerprints obtained with 26 clinical and 29 environmental isolates from the same area. Our results suggest
Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury.: J Clin Invest. 1997 Oct 15;100(8):2022-7. Unique Identifier : AIDSLINE /MED97474771; Gerard C; Frossard JL; Bhatia M; Saluja A; Gerard NP; Lu B; Steer M; Ina Sue Perlmutter Laboratory, Children's Hospital, Department of; Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School; and the Center for Blood Research, Boston, Massachusetts 02115, USA.; beta-Chemokines and their receptors mediate the trafficking and activation of a variety of leukocytes including the lymphocyte and macrophage. An array of no less than eight beta-chemokine receptors has been identified, four of which are capable of recognizing the chemokines MIP1alpha and RANTES. Genetic deletion of o
Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways.: J Clin Invest. 1997 Oct 15;100(8):2043-53. Unique Identifier : AIDSLINE /MED97474774; Blauvelt A; Asada H; Saville MW; Klaus-Kovtun V; Altman DJ; Yarchoan R; Katz SI; Dermatology Branch, National Cancer Institute, Bethesda, Maryland; 20892-1908, USA. andrew_blauvelt@nih.gov; There is substantial evidence that dendritic cells (DC) residing within epithelial surfaces (e.g., Langerhans cells) are the initial cells infected with HIV after mucosal exposure to virus. To study DC-HIV interactions in detail, we propagated Langerhans cell-like DC from cord blood CD34(+) cells and from adult blood
Responsiveness of muscle protein synthesis to growth hormone administration in HIV-infected individuals declines with severity of disease.: J Clin Invest. 1997 Oct 15;100(8):2125-32. Unique Identifier : AIDSLINE /MED97474784; McNurlan MA; Garlick PJ; Steigbigel RT; DeCristofaro KA; Frost RA; Lang CH; Johnson RW; Santasier AM; Cabahug CJ; Fuhrer J; Gelato MC; Department of Surgery, State University of New York at Stony Brook,; Stony Brook, New York 11794, USA. mcnurlan@surg.som.sunysb.edu; This study was undertaken to determine if human recombinant growth hormone (hrGH, 6 mg/d for 2 wk) would stimulate muscle protein synthesis in AIDS wasting. Healthy controls were compared with patients who were HIV+, had AIDS without weight loss, and had AIDS with > 10% weight loss. Before hrGH, rates of skeletal musc
Enterocytozoon bieneusi in AIDS: symptomatic relief and parasite changes after furazolidone.: J Clin Pathol. 1997 Jun;50(6):472-6. Unique Identifier : AIDSLINE /MED98026352; Dionisio D; Manneschi LI; Di Lollo S; Orsi A; Sterrantino G; Meli M; Gabbrielli M; Tani A; Papucci A; Leoncini F; Infectious Diseases Unit, Careggi Hospital, Florence, Italy.; AIMS: To investigate changes in morphology of the developmental stages of Enterocytozoon bieneusi and symptomatic relief observed in AIDS patients after treatment with furazolidone. METHODS: Six AIDS patients with symptomatic E bieneusi infection of the small intestine were treated with a course of furazolidone. All p
Itraconazole solution: higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis.: J Clin Pathol. 1997 Jun;50(6):477-80. Unique Identifier : AIDSLINE /MED98026353; Cartledge JD; Midgely J; Gazzard BG; St Stephen's Centre, Chelsea and Westminster Hospital, London, UK.; AIMS: To compare the serum concentrations of itraconazole and hydroxyitraconazole after treatment with itraconazole cyclodextrin solution and itraconazole capsules in human immunodeficiency virus (HIV) positive patients with oral candidosis. METHODS: The pharmacokinetics of itraconazole and its active metabolite hydro
HIV-1 detection by nested PCR and viral culture in fresh or cryopreserved postmortem skin: potential implications for skin handling and allografting.: J Clin Pathol. 1997 Jun;50(6):481-4. Unique Identifier : AIDSLINE /MED98026354; Gala JL; Vandenbroucke AT; Vandercam B; Pirnay JP; Delferriere N; Burtonboy G; Department of Clinical Molecular Biology, Saint Luc Hospital, Catholic; University of Louvain, Brussels, Belgium.; AIMS: To date, the risk relating to the handling or allografting of human immunodeficiency virus type 1 (HIV-1) infected postmortem skin remains hypothetical. While blood screening for HIV antibodies is still the key safety procedure to detect HIV infected cadavers, false negative results are a concern. Conversely, fa
The immune response in halo nevi.: J Am Acad Dermatol. 1997 Oct;37(4):620-4. Unique Identifier : AIDSLINE /MED98002888; Zeff RA; Freitag A; Grin CM; Grant-Kels JM; Department of Pathology, University of Connecticut Health Center,; Farmington 06030, USA.; The mechanism(s) responsible for halo nevus presents a provocative link with the immune response to melanoma. Although no direct demonstration of melanocyte killing has been observed by the immune effector cells found within the halo, the abundance of antigen-presenting cells in the regressing nevus and the presence o
Resolution of Kaposi's sarcoma associated with undetectable level of human herpesvirus 8 DNA in a patient with AIDS after protease inhibitor therapy.: J Am Acad Dermatol. 1997 Oct;37(4):648-9. Unique Identifier : AIDSLINE /MED98002894; Burdick AE; Carmichael C; Rady PL; Tyring SK; Badiavas E; Department of Dermatology and Cutaneous Surgery, University of Miami; School of Medicine, Florida 33136, USA.
HIV-associated eosinophilic pustular folliculitis [letter]: J Am Acad Dermatol. 1997 Oct;37(4):670-1. Unique Identifier : AIDSLINE /MED98002906; Basarab T
Histopathological changes of primary HIV infection. Description of three cases and review of the literature.: J Cutan Pathol. 1997 Sep;24(8):507-10. Unique Identifier : AIDSLINE /MED97472938; Barnadas MA; Alegre M; Baselga E; Randazzo L; Margall N; Rabella N; Curell R; de Moragas JM; Department of Dermatology, Hospital de la Sta, Barcelona, Spain.; The histopathological changes observed in the cutaneous rash of three patients who suffered the acute phase of HIV infection are described. In all three patients a perivascular and interstitial inflammatory infiltrate was present in the upper and mid-reticular dermis. In one biopsy isolated areas of epidermal necrosis
The Muir-Torre syndrome in a black patient with AIDS: histopathology and molecular genetic studies.: J Cutan Pathol. 1997 Sep;24(8):511-8. Unique Identifier : AIDSLINE /MED97472939; Warschaw KE; Eble JN; Hood AF; Wolverton SE; Halling KC; Department of Dermatology, Indiana University School of Medicine,; Indianapolis, USA.; In 1981, a black man had adenocarcinoma of the colon. In 1986, he had a sebaceous adenoma and the diagnosis of the Muir-Torre syndrome was established. The patient was found to be HIV sero-positive in 1986, and 8 years later fulfilled the CDC criteria for AIDS. During 1989 to 1993 the CD4 count was > 200 cells/ml and
HIV status and the risk of post-extraction complications.: J Dent Res. 1997 Oct;76(10):1644-52. Unique Identifier : AIDSLINE /MED97467687; Dodson TB; Department of Surgery, Emory University School of Medicine, Atlanta,; Georgia, USA.; Tooth extraction is commonly performed for patients infected with the human immunodeficiency virus (HIV). We undertook a prospective study to determine if HIV-positive patients had an increased risk for complications following tooth extraction. The study sample was composed of patients who presented for tooth extracti
Exploring attitudes of white dental students regarding willingness to treat people with HIV.: J Dent Educ. 1997 Sep;61(9):717-26. Unique Identifier : AIDSLINE /MED97462321; Driscoll JM; Hoffman MA; Counseling and Psychological Services, Duke University, Durham, NC; 27708-9095, USA.; This descriptive field study examines the willingness of ninety white dental students to provide care to people with Human Immunodeficiency Virus disease (HIV disease). This study suggests that perceived clinical ability, attitudes toward gay men, and white racial attitudes account for white dental students willingne
Treatment of the HIV-infected patient [letter]: J Am Dent Assoc. 1997 Oct;128(10):1350, 1352. Unique Identifier : AIDSLINE /MED97473273; Giambalvo AM
HIV Postexposure Prophylaxis Registry [news]: J Am Dent Assoc. 1997 Oct;128(10):1362. Unique Identifier : AIDSLINE /MED97473275
Oral health problems and use of dental services among HIV-infected adults. Supplement to HIV/AIDS Surveillance Project Group.: J Am Dent Assoc. 1997 Oct;128(10):1417-22. Unique Identifier : AIDSLINE /MED97473280; Greene VA; Chu SY; Diaz T; Schable B; Surveillance Branch of the Division of HIV/AIDS Prevention, National; Center for HIV, STD, and TB Prevention, Centers for Disease Control; and Prevention, Atlanta 30333, USA.; Between January and May 1994, a 14-question survey regarding oral symptoms and use of dental care services was added to a multistate interview project of adults infected with the human immunodeficiency virus. Results indicate that there are disparities and perceived barriers among HIV-infected adults seeking and recei
The inhibitory effects of topically active glucocorticoids on IL-4, IL-5, and interferon-gamma production by cultured primary CD4+ T cells.: J Allergy Clin Immunol. 1997 Oct;100(4):511-9. Unique Identifier : AIDSLINE /MED97478251; Umland SP; Nahrebne DK; Razac S; Beavis A; Pennline KJ; Egan RW; Billah MM; Schering-Plough Research Institute, Kenilworth, N.J. 07033, USA.; This study was conducted to directly compare the in vitro efficacy and potency of several glucocorticoids in inhibiting T-cell cytokine production. The glucocorticoids tested were fluticasone propionate, budesonide, triamcinolone acetonide, and beclomethasone dipropionate, which are currently inhaled therapies for the
HIV and medical nutrition therapy.: J Am Diet Assoc. 1997 Oct;97(10 Suppl 2):S161-6. Unique Identifier : AIDSLINE /MED97477578; Young JS; California State University, Los Angeles, USA.; In those who are infected with human immunodeficiency virus, poor nutritional status can result from numerous causes, including anorexia, catabolism, chronic infection, fever, poor nutrient intake, nausea, vomiting, diarrhea, malabsorption, metabolic disturbances, lack of access to food, depression, and side effects o
Delayed diagnosis: a 78-year-old man with AIDS [letter]: J Am Geriatr Soc. 1997 Oct;45(10):1282-3. Unique Identifier : AIDSLINE /MED97470081; Ankrom M; Greenough WB 3rd
Immune alterations in geriatric mice dosed subacutely with diethylstilbestrol (DES).: J Appl Toxicol. 1997 Sep-Oct;17(5):265-71. Unique Identifier : AIDSLINE /MED97479657; Smith BJ; Holladay SD; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland; Regional College of Veterinary Medicine, Virginia Polytechnic; Institute and State University, Blacksburg 24061-0442, USA.; Exposure to both physiological and pharmacological doses of estrogenic compounds has been reported to alter immunologic responses in humans as well as in developmental and adult murine models. Despite the current therapeutic use of potent estrogens, including diethylstilbestrol (DES), in geriatric human disorders, elu
Dynamics of hepatitis B virus infection in vivo.: J Hepatol. 1997 Sep;27(3):431-6. Unique Identifier : AIDSLINE /MED97459347; Zeuzem S; de Man RA; Honkoop P; Roth WK; Schalm SW; Schmidt JM; Medizinische Klinik II, Klinikum der Johann Wolfgang; Goethe-Universitat, Frankfurt a.M., Germany.; BACKGROUND/AIMS: Information on the kinetics of the pretreatment steady-state of HBV can be obtained from serial measurements of serum hepatitis B virus (HBV) DNA concentrations following lamivudine ((-)enantiomer of 3 -thiacytidine)-induced perturbation of the balance between virus production and clearance. METHODS:
Outbreak among HIV-infected patients of Staphylococcus aureus resistant to cotrimoxazole and methicillin.: Infect Control Hosp Epidemiol. 1997 Sep;18(9):617-21. Unique Identifier : AIDSLINE /MED97455049; Alonso R; Padilla B; Sanchez-Carrillo C; Munoz P; Rodriguez-Creixems M; Bouza E; Servicio de Microbiologia Clinica y Enfermedades Infecciosas, Hospital; General Universitario Gregorio Maranon, Madrid, Spain.; OBJECTIVE: To describe an outbreak of trimethoprim-sulfamethoxazole (cotrimoxazole)-resistant and methicillin-resistant Staphylococcus aureus (CMRSA) in a unit housing patients infected with the human immunodeficiency virus HIV). DESIGN: Prospective study involving patients colonized or infected with CMRSA. PATIENTS:
Urinary tract infection in the immunocompromised host. Lessons from kidney transplantation and the AIDS epidemic.: Infect Dis Clin North Am. 1997 Sep;11(3):707-17. Unique Identifier : AIDSLINE /MED98017691; Tolkoff-Rubin NE; Rubin RH; Massachusetts General Hospital, Boston, USA.; The occurrence of urinary tract infection and its clinical impact is determined, as with any infectious disease, by the interaction between the virulence of the infecting organism and the host defense mechanisms that can be mobilized. In the case of urinary tract infections, an anatomically and functionally intact kid
Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.: J Immunol. 1997 Nov 15;159(10):4665-75. Unique Identifier : AIDSLINE /MED98031717; Manning TC; Rund LA; Gruber MM; Fallarino F; Gajewski TF; Kranz DM; Department of Biochemistry, University of Illinois, Urbana 61801, USA.; Three sources of help for the development of a CD8+ CTL response have been described: the CD4+ direct and indirect pathways and the CD8+ direct pathway. In an effort to understand the minimal requirements for the development of a CTL response in vivo, we have bred mice transgenic for the 2C TCR onto a RAG(-/-) backgro
IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function.: J Immunol. 1997 Nov 15;159(10):4686-92. Unique Identifier : AIDSLINE /MED98031719; Cameron MJ; Arreaza GA; Zucker P; Chensue SW; Strieter RM; Chakrabarti S; Delovitch TL; The John P. Robarts Research Institute, University of Western Ontario,; London, Canada.; Beginning at the time of insulitis, nonobese diabetic (NOD) mice demonstrate a thymocyte and peripheral T cell proliferative hyporesponsiveness induced by TCR cross-linking, which is associated with reduced IL-2 and IL-4 secretion. We previously reported that NOD CD4+
Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism.: J Immunol. 1997 Nov 15;159(10):4781-92. Unique Identifier : AIDSLINE /MED98031730; Christianson GJ; Brooks W; Vekasi S; Manolfi EA; Niles J; Roopenian SL; Roths JB; Rothlein R; Roopenian DC; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; The goal of this study was to determine whether class I proteins play an important role in the regulation of Ig and to elucidate the mechanism(s) involved. We analyzed the phenotype imposed by a null allele of beta 2-microglobulin (beta 2m). Serum Ig levels of several mouse strains showed a beta 2m dependence that was
Activated T helper 1 and T helper 2 cells differentially express the beta-2-adrenergic receptor: a mechanism for selective modulation of T helper 1 cell cytokine production.: J Immunol. 1997 Nov 15;159(10):4857-67. Unique Identifier : AIDSLINE /MED98031739; Ramer-Quinn DS; Baker RA; Sanders VM; Department of Cell Biology, Neurobiology, and Anatomy, Loyola; University Medical Center, Maywood, IL 60153, USA.; We recently reported that resting clones of murine Th1 cells, but not resting Th2 cells, expressed a detectable level of the beta-2-adrenergic receptor (beta 2AR). In the present study, we proposed that the level of beta 2AR expression on anti-CD3 mAb-activated CD4+ effector Th cells may differ from the level on resti
Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.: J Immunol. 1997 Nov 15;159(10):4943-51. Unique Identifier : AIDSLINE /MED98031748; Dressel A; Chin JL; Sette A; Gausling R; Hollsberg P; Hafler DA; Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard; Medical School, Boston, MA 02115, USA.; Determination of immunodominant epitopes of MHC class I-restricted self-Ags and elucidation of TCR contact residues is of potential importance in providing a means of manipulating the immune response to self-Ags in human autoimmune diseases. A computer algorithm was used to examine the sequences of the two major encep
Cultured blood dendritic cells retain HIV-1 antigen-presenting capacity for memory CTL during progressive HIV-1 infection.: J Immunol. 1997 Nov 15;159(10):4973-82. Unique Identifier : AIDSLINE /MED98031752; Fan Z; Huang XL; Zheng L; Wilson C; Borowski L; Liebmann J; Gupta P; Margolick J; Rinaldo C; University of Pittsburgh Graduate School of Public Health, PA 15261,; USA.; Dendritic cells (DC) are potent APC that may be involved in the pathogenesis of HIV-1 infection. We studied the APC function of DC from HIV-1-infected subjects that were derived from monocyte-depleted PBMC by culture in human IL-4 and human granulocyte-macrophage CSF. The cultured cells from the HIV-1-infected subject
Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.: J Immunol. 1997 Nov 15;159(10):5014-23. Unique Identifier : AIDSLINE /MED98031757; Wynn TA; Morawetz R; Scharton-Kersten T; Hieny S; Morse HC 3rd; Kuhn R; Muller W; Cheever AW; Sher A; Laboratory of Parasitic Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892-0425, USA.; twynn@pop.niaid.nih.gov; In response to i.v.-injected eggs of Schistosoma mansoni, normal mice develop a dominant type 2 response, whereas IL-10-deficient animals generate a mixed type 1/type 2 cytokine profile and show reduced pulmonary granuloma formation. IL-4-deficient mice, while displaying diminished type 2 responses and granulomatous i
Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response.: J Immunol. 1997 Nov 15;159(10):5024-31. Unique Identifier : AIDSLINE /MED98031758; Hondowicz BD; Scharton-Kersten TM; Jones DE; Scott P; Department of Pathobiology, University of Pennsylvania School of; Veterinary Medicine, Philadelphia 19104, USA.; Leishmania major-infected C3H mice develop a Th1 response, but studies have shown that treatment of C3H mice with anti-IL-12 or anti-IFN-gamma mAb promotes the development of a Th2 response and susceptibility. However, we discovered that C3H mice treated for 3 wk with either anti-IL-12 or anti-IFN-gamma mAb eventually
Human monoclonal antibodies to the V3 loop of HIV-1 with intra- and interclade cross-reactivity.: J Immunol. 1997 Nov 15;159(10):5114-22. Unique Identifier : AIDSLINE /MED98031769; Gorny MK; VanCott TC; Hioe C; Israel ZR; Michael NL; Conley AJ; Williams C; Kessler JA 2nd; Chigurupati P; Burda S; Zolla-Pazner S; New York University Medical Center, NY 10016, USA.; Five human anti-V3 mAbs were generated from Ab-producing cells derived from the blood of HIV-1-infected individuals from North America and selected using the V3 peptide of a divergent clade B isolate, HIV(RF). The anti-V3(RF) mAbs were mapped to a cluster of three overlapping epitopes present in the KSITKGP sequence l
CD28 costimulation increases CD8+ cell suppression of HIV replication.: J Immunol. 1997 Nov 15;159(10):5123-31. Unique Identifier : AIDSLINE /MED98031770; Barker E; Bossart KN; Fujimura SH; Levy JA; Department of Medicine, University of California School of Medicine,; San Francisco 94143, USA.; A subset of CD8+ T lymphocytes that expresses CD28, a membrane receptor for B7 differentiation Ags found on APCs, is primarily responsible for the noncytotoxic suppression of HIV replication in CD4+ cells of HIV-infected individuals. Optimal inhibition of HIV production by CD8+ cells occurs after triggering the CD28 m
Recombinant T cell receptor molecules can prevent and reverse experimental autoimmune encephalomyelitis: dose effects and involvement of both CD4 and CD8 T cells.: J Immunol. 1997 Nov 15;159(10):5150-6. Unique Identifier : AIDSLINE /MED98031773; Kumar V; Coulsell E; Ober B; Hubbard G; Sercarz E; Ward ES; Department of Microbiology and Molecular Genetics, University of; California, Los Angeles 90095, USA.; Autoimmune diseases are often characterized by spontaneous remission followed by relapses. Although the mechanism(s) controlling pathogenic self-reactive T cells are not fully understood, recent data in experimental autoimmune encephalomyelitis (EAE), a prototype for CD4 T cell-mediated autoimmune diseases, indicate t
Comparison of HIV-1 envelope-specific CD4+ T cell lines simultaneously established from peripheral blood mononuclear cells and lymph node biopsy in HIV-1-infected individuals.: J Immunol. 1997 Nov 15;159(10):5162-7. Unique Identifier : AIDSLINE /MED98031775; Ratto-Kim S; Sitz KV; Scherer AM; Kim JH; Anderson DW; Nau ME; Mann DL; Akolkar PN; Gulwani-Akolkar B; Silver J; Birx DL; Henry M. Jackson Foundation, Rockville, MD 20850, USA.; skim@hiv.hjf.org; HIV-1 envelope-specific CD4+ T cell lines were established simultaneously from PBMC and lymph node mononuclear cells of two HIV-1-infected patients. Three recombinant envelope proteins were used to establish the CD4+ T cell lines: gp160NL4-3, gp120IIIB, and gp120MN. Six T cell lines were established from the first pat
CD4+ Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristane-induced arthritis.: J Immunol. 1997 Oct 15;159(8):3692-7. Unique Identifier : AIDSLINE /MED98018227; Beech JT; Siew LK; Ghoraishian M; Stasiuk LM; Elson CJ; Thompson SJ; Department of Pathology and Microbiology, University of Bristol,; United Kingdom.; Previous studies showed that mice with pristane-induced arthritis PIA) and those protected from the disease by preimmunization with mycobacterial 65-kDa heat shock protein (hsp65), possess raised immune responses to hsp65. Thus, a paradox exists whereby T cells from both arthritic and hsp65-protected animals prolifera
IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent.: J Immunol. 1997 Oct 15;159(8):3731-8. Unique Identifier : AIDSLINE /MED98018232; Huang H; Hu-Li J; Chen H; Ben-Sasson SZ; Paul WE; Laboratory of Immunology, National Institute of Allergy and Infectious; Diseases, Bethesda, MD 20892-1892, USA.; CD4+ T cell differentiation into cells capable of producing IL-4 and IL-13 (Th2 cells) requires the presence of IL-4 and is STAT-6 dependent. Here we show that IL-4 is not required for IL-4 or IL-13 production by Th2 cells. Anti-IL-4 or anti-IL-4R Ab did not diminish IL-4 production by Th2 cells in response to TCR-med
The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL.: J Immunol. 1997 Oct 15;159(8):3748-56. Unique Identifier : AIDSLINE /MED98018234; Hadley GA; Bartlett ST; Via CS; Rostapshova EA; Moainie S; Department of Surgery, University of Maryland Medical School,; Baltimore 21201, USA. GHADLEY@SURGERY2.AB.UMD.EDU; The interaction of CD8+CTL with epithelial layers is an important but poorly defined aspect of organ allograft rejection. We herein report that CD103 (formerly alpha E integrin), a known receptor for the epithelial cell-specific ligand E-cadherin, is expressed by a major subset of CD8 + CTL elicited in response to all
Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells.: J Immunol. 1997 Oct 15;159(8):3823-37. Unique Identifier : AIDSLINE /MED98018243; Czerniecki BJ; Carter C; Rivoltini L; Koski GK; Kim HI; Weng DE; Roros JG; Hijazi YM; Xu S; Rosenberg SA; Cohen PA; Department of Surgery, University of Pennsylvania Medical Center,; Philadelphia 19104, USA.; Human peripheral blood contains a small subpopulation of immature dendritic cells (iDC) distinguished from circulating monocytes by their low expression of CD14. We utilized leukapheresis and countercurrent centrifugal elutriation to obtain myeloid origin mononuclear cell (MOMC) fractions of monocytes and iDC for stud
Depletion of CD8+ T lymphocytes by murine monoclonal CD8 antibodies and restored specific T cell proliferation in vivo in a patient with chronic hepatitis C.: J Immunol. 1997 Oct 15;159(8):4064-71. Unique Identifier : AIDSLINE /MED98018269; Kiefersauer S; Reiter C; Eisenburg J; Diepolder HM; Rieber EP; Riethmuller G; Gruber R; Institute for Immunology, Klinikum Grosshadern, University of Munich,; Germany.; Cellular immune mechanisms, especially those mediated by CD8+ T cells, are important in the pathogenesis and control of viral infections. On the other hand, as shown for chronic lymphocytic choriomeningitis virus infection in the mouse, CD8+ T cells may not only hinder the elimination of a virus, but make the host unr
Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression.: J Immunol. 1997 Oct 15;159(8):4077-83. Unique Identifier : AIDSLINE /MED98018271; Lafrenie RM; Wahl LM; Epstein JS; Yamada KM; Dhawan S; Craniofacial Developmental Biology and Regeneration Branch, National; Institute of Dental Research, Bethesda, MD 20892, USA.; Treatment of primary monocytes with soluble HIV-Tat protein is associated with increased monocyte metalloproteinase-9 (MMP-9) expression and enhanced beta 2 integrin expression that increases monocyte/endothelial adhesion. These alterations require greater than 12 h of HIV-Tat treatment, suggesting the involvement of
Role of passenger leukocytes in allograft rejection: effect of depletion of donor alveolar macrophages on the local production of TNF-alpha, T helper 1/T helper 2 cytokines, IgG subclasses, and pathology in a rat model of lung transplantation.: J Immunol. 1997 Oct 15;159(8):4084-93. Unique Identifier : AIDSLINE /MED98018272; Sekine Y; Bowen LK; Heidler KM; Van Rooijen N; Brown JW; Cummings OW; Wilkes DS; Division of Cardiothoracic Surgery, Indiana University School of; Medicine, Indianapolis 46202, USA.; Acute lung allograft rejection is believed to be initiated by passenger leukocytes, such as alveolar macrophages (AM), in the donor organ, which release TNF-alpha, and present alloantigens to host lymphocytes, to up-regulated Th1 cellular and humoral immunity. However, the role of donor AM in local TNF-alpha synthesis
Regulation of nuclear factor-kappa B and its inhibitor I kappa B-alpha/MAD-3 in monocytes by Mycobacterium tuberculosis and during human tuberculosis.: J Immunol. 1997 Oct 15;159(8):4109-16. Unique Identifier : AIDSLINE /MED98018275; Toossi Z; Hamilton BD; Phillips MH; Averill LE; Ellner JJ; Salvekar A; Division of Infectious Diseases, Case Western Reserve University,; Cleveland, OH 44106-4984, USA. zxt2@p.o.cwru.edu; Blood monocytes from patients with active tuberculosis are activated in vivo, as evidenced by an increase in the stimulated release of proinflammatory cytokines, such as TNF-alpha, and the spontaneous expression of IL-2R. Further, monocytes from patients demonstrate an augmented susceptibility to a productive infectio
Distinct roles for B7-1 and B7-2 determinants during priming of effector CD8+ Tc1 and regulatory CD4+ Th2 cells for contact hypersensitivity.: J Immunol. 1997 Nov 1;159(9):4217-26. Unique Identifier : AIDSLINE /MED98026138; Xu H; Heeger PS; Fairchild RL; Department of Immunology, Cleveland Clinic Foundation, OH 44195-0001,; USA.; Contact hypersensitivity (CHS) is a CD8+ T cell-mediated response to hapten sensitization and challenge of the epidermis. Both the IFN-gamma-producing effector CD8+ T cells and the IL-4/IL-10-producing CD4+ T (Th2) cells that restrict the magnitude and duration of the response are primed by hapten-presenting Langerhan
Cellular requirements for the activation and proliferation of ruminant gammadelta T cells.: J Immunol. 1997 Nov 1;159(9):4287-94. Unique Identifier : AIDSLINE /MED98026146; Hanrahan CF; Kimpton WG; Howard CJ; Parsons KR; Brandon MR; Andrews AE; Nash AD; Center for Animal Biotechnology, University of Melbourne School of; Veterinary Science, Australia.; Requirements for the activation and proliferation of gammadelta T cells were investigated. Maximum numbers of gammadelta T cells expressed the IL-2R alpha-chain after 6-h Con A stimulation in peripheral blood, efferent lymph, and afferent lymph. In comparison, IL-2R alpha-chain expression on CD4 T cells only reached m
Activation and migration of CD8 T cells in the intestinal mucosa.: J Immunol. 1997 Nov 1;159(9):4295-306. Unique Identifier : AIDSLINE /MED98026147; Kim SK; Reed DS; Heath WR; Carbone F; Lefrancois L; Division of Rheumatic Diseases, University of Connecticut Health; Center, Farmington 06030, USA.; The activation of CD8 T cells was studied using transgenic mice expressing an MHC class I-restricted OVA-specific TCR (OT-I). Immunization of OT-I mice resulted in activation of lymph node T cells and up-regulation of expression of B220, CD11a, and CD44 and caused a preferential loss of mucosal-type T cells from the p
Reversal of human allergic T helper 2 responses by engagement of signaling lymphocytic activation molecule.: J Immunol. 1997 Nov 1;159(9):4316-21. Unique Identifier : AIDSLINE /MED98026149; Carballido JM; Aversa G; Kaltoft K; Cocks BG; Punnonen J; Yssel H; Thestrup-Pedersen K; de Vries JE; Department of Human Immunology, DNAX Research Institute of Molecular; and Cellular Biology, Palo Alto, CA 94304, USA.; Allergen-specific Th2 cells accumulate at high frequencies in the skin of patients with atopic dermatitis (AD), where they contribute to the induction and maintenance of the lesions that are characteristic for the disease. Attenuation of these lesions in response to successful therapy is associated with a reduction in
Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry.: J Immunol. 1997 Nov 1;159(9):4322-9. Unique Identifier : AIDSLINE /MED98026150; Moriuchi M; Moriuchi H; Turner W; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1576, USA.; The chemokine receptor CXCR4 (also designated fusin and LESTR) is a cofactor for fusion and entry of T cell-tropic strains of HIV-1. CXCR4 is expressed in various cell types; however, the mechanisms involved in the regulation of its expression remain unknown. To delineate these mechanisms, approximately 1.2 kb of DNA
Alteration of glycosylation renders HIV sensitive to inactivation by normal human serum.: J Immunol. 1997 Nov 1;159(9):4356-61. Unique Identifier : AIDSLINE /MED98026154; Reed DJ; Lin X; Thomas TD; Birks CW; Tang J; Rother RP; Department of Molecular Development, Alexion Pharmaceuticals, New; Haven, CT 06511, USA.; Retroviruses from various mammalian species, excluding humans, are effectively inactivated in normal human serum (NHS). Recent studies have shown that NHS inactivation of retroviruses occurs through natural Ab recognition of a terminal glycosidic moiety on the viral envelope that is acquired during replication in the
Intracytoplasmic delivery of listeriolysin O by a vaccinal strain of Bacillus anthracis induces CD8-mediated protection against Listeria monocytogenes.: J Immunol. 1997 Nov 1;159(9):4435-43. Unique Identifier : AIDSLINE /MED98026164; Sirard JC; Fayolle C; de Chastellier C; Mock M; Leclerc C; Berche P; Unite de Toxines et Pathogenie Bacteriennes, URA 1858 CNRS, Institut; Pasteur, Paris, France.; The facultative intracellular pathogen Listeria monocytogenes secretes a 58-kDa hemolysin, listeriolysin O (LLO), that allows bacteria to access the cytoplasm and to multiply inside infected cells. LLO is also a protective Ag required for the development of specific immunity. We studied the capacity of a new bacterial
B7-2 blockade enhances T cell responses to Leishmania donovani.: J Immunol. 1997 Nov 1;159(9):4460-6. Unique Identifier : AIDSLINE /MED98026167; Murphy ML; Engwerda CR; Gorak PM; Kaye PM; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, United Kingdom.; Infection with Leishmania donovani has been reported to induce a dominant Th1-type response in all strains of mice examined, providing a model for examining the regulation of Th1 responses in the relative absence of Th2 cross-regulation. Here we demonstrate that blockade of the costimulatory molecule B7-2, but not B7-
Distinct CD4+ T cell helper requirements in Theileria parva-immune and naive bovine CTL precursors.: J Immunol. 1997 Nov 1;159(9):4539-45. Unique Identifier : AIDSLINE /MED98026177; Taracha EL; Awino E; McKeever DJ; International Livestock Research Institute, Nairobi, Kenya.; E.Taracha@cgnet.com; There is strong evidence that class I MHC-restricted parasite-specific CD8+ CTL protect cattle against the protozoan parasite Theileria parva. As part of an effort to develop a subunit vaccine for the induction of these responses, we have investigated the factors involved in the generation of T. parva-specific CTL in
Regulation of anti-HIV-1 activity of RANTES by heparan sulfate proteoglycans.: J Immunol. 1997 Nov 1;159(9):4587-92. Unique Identifier : AIDSLINE /MED98026182; Oravecz T; Pall M; Wang J; Roderiquez G; Ditto M; Norcross MA; Division of Hematologic Products, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, MD 20892, USA.; The role of cell surface proteoglycans in CC chemokine-mediated anti-HIV-1 activity in T cells and macrophages was investigated. Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to
CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.: J Immunol. 1997 Nov 1;159(9):4620-7. Unique Identifier : AIDSLINE /MED98026186; Balasa B; Krahl T; Patstone G; Lee J; Tisch R; McDevitt HO; Sarvetnick N; Department of Immunology, The Scripps Research Institute, La Jolla, CA; 92037, USA.; The nonobese diabetic (NOD) mouse spontaneously develops T cell-dependent autoimmune diabetes. Here, we investigate the role of CD40 ligand (CD40L)-CD40 costimulation in the initiation and progression of this disease. Anti-CD40L mAb treatment of 3- to 4-wk-old NOD females (the age at which insulitis typically begins)
Single-cell cytokine profiles in normal humans: comparison of flow cytometric reagents and stimulation protocols.: J Immunol Methods. 1997 Aug 22;207(1):13-22. Unique Identifier : AIDSLINE /MED97469110; Jason J; Larned J; Immunology Branch, Centers for Disease, Control and Prevention CDC),; U.S. Department of Health and Human Services (DHHS), U.S. Public; Health Service (PHS), Atlanta, GA 30333, USA.; Cytokines are produced and function at a micro environmental level: intracellular assessment has only recently become practically feasible. We used 3-color flow cytometry to examine surface and cytoplasmic antigens on peripheral blood lymphocytes of 18 normal donors, assessing the applicability/comparability of variou
Generation of neutralizing antibody to the reverse transcriptase of human immunodeficiency virus type 1 by immunizing of mice with an infectious vaccinia virus recombinant.: J Immunol Methods. 1997 Aug 22;207(1):53-60. Unique Identifier : AIDSLINE /MED97469114; Chiba J; Nakano M; Suzuki Y; Aoyama K; Ohba H; Kobayashi T; Yasuda A; Kojima A; Kurata T; Department of Biological Science and Technology, Science University of; Tokyo, Chiba, Japan. chibaj@rs.noda.sut.ac.jp; Antibodies inhibiting the reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1) were found to be generated in the serum of mice repeatedly infected with a vaccinia virus recombinant, WRRT, expressing the enzyme. A monoclonal antibody mAb), 7C4, which specifically and almost completely inhibits the
A rapid streptavidin-capture ELISA specific for the detection of antibodies to feline foamy virus.: J Immunol Methods. 1997 Aug 22;207(1):69-77. Unique Identifier : AIDSLINE /MED97469116; Winkler IG; Lochelt M; Levesque JP; Bodem J; Flugel RM; Flower RL; School of Pharmacy and Medical Science, University of South Australia,; Adelaide, Australia.; We report a simple procedure for the rapid development of an ELISA with the potential for wide application to any defined protein antigen. The procedure involves the expression of protein encoded by a PCR product, using a commercially available T-vector that adds a biotin tag, and a single step purification by affinit
The impact of HIV infection on lactose absorptive capacity.: J Infect. 1997 Jul;35(1):31-5. Unique Identifier : AIDSLINE /MED97425671; Corazza GR; Ginaldi L; Furia N; Marani-Toro G; Di Giammartino D; Quaglino D; Department of Internal Medicine, University of L'Aquila, Italy.; Forty HIV-infected adult patients at different disease stages and 44 healthy volunteers were evaluated for lactose malabsorption using the hydrogen breath test after 20 g lactose ingestion. All subjects were previously tested for breath hydrogen (H2) excretion after 12 g lactulose ingestion. The presence of intestinal
Procalcitonin as a marker of bacterial sepsis in patients infected with HIV-1.: J Infect. 1997 Jul;35(1):41-6. Unique Identifier : AIDSLINE /MED97425673; Gerard Y; Hober D; Assicot M; Alfandari S; Ajana F; Bourez JM; Chidiac C; Mouton Y; Bohuon C; Wattre P; Laboratoire de Virologie, Batiment I.R.F.P.P.S., CHU, Lille, France.; Procalcitonin (ProCT) is a recently described marker of severe sepsis. It was decided to assess the value of proCT as a marker of secondary infection in patients infected with HIV-1. ProCT plasma levels were measured by immunoluminometric assay in a prospective study in 155 HIV-infected individuals: 102 asymptomatic a
Monitoring antiretroviral activity using ICDp24 and CD4 counts in HIV infection.: J Infect. 1997 Jul;35(1):67-71. Unique Identifier : AIDSLINE /MED97425677; Lillo FB; Maillard M; Saracco A; Varnier OE; Laboratory of Virology and Infectious Disease Clinic, AIDS Centre San; Luigi IRCCS HSR, Milano, Italy.; The fluctuations of HIV-1 p24 antigen concentration have been monitored in the follow-up of 118 subjects in different clinical stages and compared to their CD4 cell count; 104 patients received antiretroviral therapy. Persistent (65%) or sporadic 28%) antigenaemia has been detected in most patients in different clinic
Outpatient parenteral antimicrobial therapy: experience in a large teaching hospital.: J Infect. 1997 Jul;35(1):73-6. Unique Identifier : AIDSLINE /MED97425678; Wiselka MJ; Nicholson KG; Department of Infectious Diseases and Tropical Medicine, Leicester; Royal Infirmary, U.K.; OBJECTIVE: to determine the practicality of treatment of infectious conditions requiring prolonged parenteral antimicrobial therapy. METHOD: review of all patients admitted to a Regional Infectious Diseases (ID) Unit who received outpatient parenteral therapy over a 12-month period. The study identified the conditions
Cytomegalovirus encephalomyelomeningoradiculitis in acquired immunodeficiency syndrome (AIDS).: J Infect. 1997 Jul;35(1):78-81. Unique Identifier : AIDSLINE /MED97425680; Luttmann S; Husstedt IW; Lugering N; Heese C; Stoll R; Domschke W; Evers S; Kuchelmeister K; Gullotta F; Department of Neurology, University of Munster, Germany.; Acute inflammatory polyradiculitis represents an uncommon peripheral nerve complication during HIV infection. The case of an HIV-seropositive patient who was admitted to hospital for a cauda equina syndrome is reported. Despite early application of anticytomegalic medication, a cytomegalovrirus (
Central nervous system involvement as a relapse of disseminated histoplasmosis in an Italian AIDS patient.: J Infect. 1997 Jul;35(1):83-4. Unique Identifier : AIDSLINE /MED97425682; Vullo V; Mastroianni CM; Ferone U; Trinchieri V; Folgori F; Lichtner M; D'Agostino C; Department of Infectious and Tropical Diseases, La Sapienza; University, Policlinico Umberto I, Rome, Italy.; A case of an Italian AIDS patient who developed both meningitis and cerebral mass lesion as a final relapse of disseminated histoplasmosis is reported. Central nervous system (CNS) involvement occurred while the patient was receiving both amphotericin B and itraconazole as maintenance therapy, thus indicating the diff
Isospora belli in a patient with AIDS.: J Infect. 1997 Jul;35(1):94-5. Unique Identifier : AIDSLINE /MED97425688; Hamour A; Curry A; Ridge A; Baily G; Wilson G; Mandal B; Department of Infectious Diseases & Tropical Medicine (Monsal Unit),; North Manchester General Hospital, U.K.
Response to hepatitis A vaccination in human immunodeficiency virus-infected and -uninfected homosexual men.: J Infect Dis. 1997 Oct;176(4):1064-7. Unique Identifier : AIDSLINE /MED97472343; Neilsen GA; Bodsworth NJ; Watts N; Sydney Sexual Health Centre, Sydney Hospital, NSW, Australia.; The influence of human immunodeficiency virus (HIV) infection and vaccination schedule on the immunogenicity of a hepatitis A vaccine was examined. Ninety HIV-infected homosexual men received two vaccinations with hepatitis A vaccine (each 2 mL of 720 ELISA units/mL) either 1 or 6 months apart; 44 HIV-uninfected men r
Polymerase chain reaction detection and clinical significance of varicella-zoster virus in cerebrospinal fluid from human immunodeficiency virus-infected patients.: J Infect Dis. 1997 Oct;176(4):1080-4. Unique Identifier : AIDSLINE /MED97472347; Burke DG; Kalayjian RC; Vann VR; Madreperla SA; Shick HE; Leonard DG; Department of Medicine, University Hospitals of Cleveland, Ohio, USA.; Varicella-zoster virus (VZV) causes ocular and other central nervous system (CNS) disease in human immunodeficiency virus HIV)-infected persons. To study the prevalence of CNS disease due to VZV, cerebrospinal fluid (CSF) specimens from 84 consecutive HIV-infected patients with new neurologic symptoms were tested for
Delayed-type hypersensitivity skin testing using third variable loop peptides identifies T lymphocyte epitopes in human immunodeficiency virus-infected persons.: J Infect Dis. 1997 Oct;176(4):1085-9. Unique Identifier : AIDSLINE /MED97472348; Sitz KV; Loomis-Price LD; Ratto-Kim S; Kenner JR; Sau P; Eckels KH; Redfield RR; Birx DL; Division of Retrovirology, Walter Reed Army Institute of Research, and; Henry M. Jackson Foundation, Rockville, Maryland, USA.; Cellular immune responses to human immunodeficiency virus type 1 HIV-1) infection, particularly in vivo responses, have been difficult to study in large patient cohorts because of technical impediments. By use of small peptide fragments of the HIV-1 gp120 third variable loop, the CD4 T lymphocyte epitopes of 2 HIV-inf
Is crusted (Norwegian) scabies a marker of adult T cell leukemia/lymphoma in human T lymphotropic virus type I-seropositive patients?: J Infect Dis. 1997 Oct;176(4):1090-2. Unique Identifier : AIDSLINE /MED97472349; del Giudice P; Sainte Marie D; Gerard Y; Couppie P; Pradinaud R; Department of Dermatology, Hopital General de Cayenne, French Guiana.; Human T cell lymphotropic virus type I (HTLV-I)-induced immunosuppression has been suggested to explain the occurrence of crusted scabies in HTLV-I-infected patients. HTLV-I is the etiologic agent of adult T cell leukemia/lymphoma (ATL). Crusted scabies diagnosed in 6 HTLV-I-seropositive patients was studied to look f
CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status.: J Infect Dis. 1997 Oct;176(4):1093-6. Unique Identifier : AIDSLINE /MED97472350; Hoffman TL; MacGregor RR; Burger H; Mick R; Doms RW; Collman RG; Department of Pathology, University of Pennsylvania School of; Medicine, Philadelphia 19104-6060, USA.; Persons who are homozygous for the delta32 polymorphism of the CCR5 chemokine receptor gene are highly protected against human immunodeficiency virus type 1 (HIV-1) infection. Previous studies described 54 HIV-1-discordant couples in whom no virus transmission occurred despite extensive sexual contact. The possible ro
Cryptosporidiosis in adults in Lusaka, Zambia, and its relationship to oocyst contamination of drinking water.: J Infect Dis. 1997 Oct;176(4):1120-3. Unique Identifier : AIDSLINE /MED97472357; Kelly P; Baboo KS; Ndubani P; Nchito M; Okeowo NP; Luo NP; Feldman RA; Farthing MJ; Digestive Diseases Research Centre, St. Bartholomew's and the Royal; London School of Medicine and Dentistry, London, United Kingdom.; In Lusaka, where human immunodeficiency virus seroprevalence in young adults is approximately 25%, four townships were studied to establish the prevalence of persistent diarrhea in adults and the etiologic importance of cryptosporidiosis in adults with persistent diarrhea. Cryptosporidium parvum oocyst contamination o
A randomized, double-blind, placebo-controlled trial of cidofovir gel for the treatment of acyclovir-unresponsive mucocutaneous herpes simplex virus infection in patients with AIDS.: J Infect Dis. 1997 Oct;176(4):892-8. Unique Identifier : AIDSLINE /MED97472321; Lalezari J; Schacker T; Feinberg J; Gathe J; Lee S; Cheung T; Kramer F; Kessler H; Corey L; Drew WL; Boggs J; McGuire B; Jaffe HS; Safrin S; Mt. Zion Medical Center and San Francisco General Hospital, University; of California, USA.; The safety and efficacy of cidofovir gel for treatment of acyclovir-unresponsive herpes simplex virus infections in AIDS patients was evaluated in a randomized, double-blind, multicenter trial. Cidofovir (0.3% or 1%) or placebo gel was applied once daily for 5 days. Ten of 20 cidofovir-treated and none of 10 placebo-t
Mutations in the pol gene of human immunodeficiency virus type 1 in infected patients receiving didanosine and hydroxyurea combination therapy.: J Infect Dis. 1997 Oct;176(4):899-903. Unique Identifier : AIDSLINE /MED97472322; De Antoni A; Foli A; Lisziewicz J; Lori F; Research Institute for Genetic and Human Therapy, Washington, DC, USA.; The pattern of mutations in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) strains that confer resistance to didanosine (ddI) was analyzed in 2 groups of patients receiving either ddI monotherapy or ddI plus hydroxyurea HU) combination therap
Long-term evaluation of cellular immunity during antiretroviral therapy and immunization with human immunodeficiency virus type 1 HIV-1) Env glycoprotein in HIV-1-infected persons.: J Infect Dis. 1997 Oct;176(4):904-12. Unique Identifier : AIDSLINE /MED97472323; Carlesimo M; Pontesilli O; Guerra EC; Varani AR; Bernardi ML; Ricci G; Alario C; Pirillo MF; Mattiacci G; Leone P; Cassone A; Aiuti F; Clinical Immunology and Allergy, University of Rome La Sapienza, and; Istituto Superiore di Sanita, Italy.; Cellular immune responses to human immunodeficiency virus type 1 HIV-1) antigens, microbial recall antigens, and CD3 monoclonal antibody were studied in HIV-1-infected asymptomatic patients in a phase II, double-blind trial of immunization with recombinant HIV-1 gp160 in or not in association with zidovudine. A vigoro
Effects of intravenous immunoglobulin in vivo on abnormally increased tumor necrosis factor-alpha activity in human immunodeficiency virus type 1 infection.: J Infect Dis. 1997 Oct;176(4):913-23. Unique Identifier : AIDSLINE /MED97472324; Aukrust P; Hestdal K; Lien E; Bjerkeli V; Nordoy I; Espevik T; Muller F; Froland SS; Medical Department A and Research Institute for Internal Medicine,; University of Oslo, National Hospital, Rikshospitalet, Norway.; The effect of a single bolus injection (0.4 g/kg) of intravenous immunoglobulin (IVIG) on the tumor necrosis factor (TNF) system in human immunodeficiency virus type 1 (HIV-1)-infected patients was investigated. At 140 h after infusion, there was a significant decrease in levels of TNF-alpha and a significant increase
Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection.: J Infect Dis. 1997 Oct;176(4):924-32. Unique Identifier : AIDSLINE /MED97472325; Pilgrim AK; Pantaleo G; Cohen OJ; Fink LM; Zhou JY; Zhou JT; Bolognesi DP; Fauci AS; Montefiori DC; Department of Surgery, Duke University Medical Center, Durham, North; Carolina 27710, USA.; The role of neutralizing antibodies in human immunodeficiency virus type 1 (HIV-1) infection is poorly understood and was assessed by evaluating responses at different stages of infection. Undiluted sera from long-term nonprogressors (LTNP) had broad neutralizing antibodies against heterologous primary isolates and we
In vitro characterization of adult primary human immunodeficiency virus type 1: demonstration of distinctive single-cell killing phenotypes in spite of similar levels of viral replication.: J Infect Dis. 1997 Oct;176(4):933-40. Unique Identifier : AIDSLINE /MED97472326; Pal A; Greenough TC; Sullivan JL; Somasundaran M; Department of Pediatrics, University of Massachusetts Medical Center,; Worcester, USA.; Two primary human immunodeficiency virus (HIV)-1 biologic clones have been studied extensively in a system using CD4 T cell-enriched peripheral blood lymphocytes and anti-CD4 antibody to measure viral replication kinetics and single-cell cytopathicity. Biologic clones from a person with AIDS replicated to high levels
Factors associated with increased levels of human immunodeficiency virus type 1 DNA in semen.: J Infect Dis. 1997 Oct;176(4):941-7. Unique Identifier : AIDSLINE /MED97472327; Xu C; Politch JA; Tucker L; Mayer KH; Seage GR 3rd; Anderson DJ; Department of Obstetrics, Gynecology, and Reproductive Biology,; Brigham and Women's Hospital, Harvard Medical School, Boston,; Massachusetts, USA.; Human immunodeficiency virus type 1 (HIV-1)-infected cells have been isolated from semen and may be a major source of transmissible virus. Quantitative polymerase chain reaction (PCR) assay was used to determine HIV proviral DNA load in cellular fractions of semen from 74 antiviral therapy-naive HIV-1-seropositive men
Superinfection with human immunodeficiency virus type 2 can reactivate virus production in baboons but is contained by a CD8 T cell antiviral response.: J Infect Dis. 1997 Oct;176(4):948-59. Unique Identifier : AIDSLINE /MED97472328; Locher CP; Blackbourn DJ; Barnett SW; Murthy KK; Cobb EK; Rouse S; Greco G; Reyes-Teran G; Brasky KM; Carey KD; Levy JA; Department of Medicine, University of California, San Francisco; 94143-1270, USA.; An animal model was used to assess whether resistance to superinfection by human immunodeficiency virus (HIV) can exist in vivo. Asymptomatic baboons (Papio cynocephalus), previously infected with HIV-2, were first challenged with homologous virus HIV-2UC2 or HIV-2UC14) and later with heterologous virus HIV-2UC12). Af
T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen.: J Infect Dis. 1997 Oct;176(4):960-8. Unique Identifier : AIDSLINE /MED97472329; Quayle AJ; Xu C; Mayer KH; Anderson DJ; Department of Obstetrics, Gynecology, and Reproductive Biology,; Brigham and Women's Hospital, Harvard Medical School, Boston,; Massachusetts, USA.; The cellular fraction of semen contains spermatozoa, immature germ cells, leukocytes, and epithelial cells. Recent evidence implicates seminal cells as a major source of sexually transmitted human immunodeficiency virus (HIV) in semen, but the identity and infectious potential of infected cells remains poorly understo
Clinical cryptosporidiosis and human immunodeficiency virus HIV)-induced immunosuppression: findings from a longitudinal study of HIV-positive and HIV-negative former injection drug users.: J Infect Dis. 1997 Oct;176(4):969-75. Unique Identifier : AIDSLINE /MED97472330; Pozio E; Rezza G; Boschini A; Pezzotti P; Tamburrini A; Rossi P; Di Fine M; Smacchia C; Schiesari A; Gattei E; Zucconi R; Ballarini P; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome, Italy.; The natural history of cryptosporidiosis was investigated during a waterborne outbreak among 1731 members of a drug rehabilitation community in Italy ; 19.6% of the members were positive for human immunodeficiency virus (HIV). Demographic and clinical information and pre-outbreak ser
Genetic similarity among Mycobacterium avium isolates from blood, stool, and sputum of persons with AIDS.: J Infect Dis. 1997 Oct;176(4):976-83. Unique Identifier : AIDSLINE /MED97472331; Mazurek GH; Chin DP; Hartman S; Reddy V; Horsburgh CR Jr; Green TA; Yajko DM; Hopewell PC; Reingold AL; Crawford JT; National Center for Infectious Diseases, Centers for Disease Control; and Prevention, Atlanta, Georgia 30333, USA.; Large-restriction-fragment pattern comparison of Mycobacterium avium from 85 blood, stool, and respiratory specimens from 25 human immunodeficiency virus-infected San Francisco patients revealed 4 strains that infected multiple people (3 groups of 2 patients and 1 group of 3 patients). Most patients harbored a single
Risk for retinitis in patients with AIDS can be assessed by quantitation of threshold levels of cytomegalovirus DNA burden in blood.: J Infect Dis. 1997 Nov;176(5):1146-55. Unique Identifier : AIDSLINE /MED98022670; Rasmussen L; Zipeto D; Wolitz RA; Dowling A; Efron B; Merigan TC; Center for AIDS Research at Stanford, Department of Medicine, Stanford; University, California 94305, USA.; Cytomegalovirus ( CMV ) retinitis in patients infected with human immunodeficiency virus (HIV) is a significant clinical problem. Seventy-five patients with CD4 T cell counts
Stavudine plus lamivudine in advanced human immunodeficiency virus disease: a short-term pilot study.: J Infect Dis. 1997 Nov;176(5):1156-60. Unique Identifier : AIDSLINE /MED98022671; Rouleau D; Conway B; Raboud J; Rae S; Fransen S; Shillington A; Zala C; O'Shaughnessy MV; Montaner JS; British Columbia Centre for Excellence in HIV/AIDS, and Canadian HIV; Trials Network, St. Paul's Hospital, University of British Columbia,; Vancouver.; The short-term effects of stavudine ( d4T ) plus lamivudine ( 3TC ) were evaluated among 48 human immunodeficiency viru
Predicting clinical progression or death in subjects with early-stage human immunodeficiency virus (HIV) infection: a comparative analysis of quantification of HIV RNA, soluble tumor necrosis factor type II receptors, neopterin, and beta2-microglobulin. Multicenter AIDS Cohort Study.: J Infect Dis. 1997 Nov;176(5):1161-7. Unique Identifier : AIDSLINE /MED98022672; Stein DS; Lyles RH; Graham NM; Tassoni CJ; Margolick JB; Phair JP; Rinaldo C; Detels R; Saah A; Bilello J; Department of Medicine, Albany Medical College, New York 12208, USA.; Quantification of human immunodeficiency virus (HIV) RNA by branched-chain DNA signal amplification, measurement of soluble tumor necrosis factor type II receptors (sTNFR-II), neopterin, beta2-microglobulin, or CD4 cell counts can be used to predict the risk of clinical progression or death in HIV infection but have n
Chemokine-independent in vitro resistance to human immunodeficiency virus (HIV-1) correlating with low viremia in long-term and recently infected HIV-1-positive persons.: J Infect Dis. 1997 Nov;176(5):1168-74. Unique Identifier : AIDSLINE /MED98022673; Schwartz DH; Castillo RC; Arango-Jaramillo S; Sharma UK; Song HF; Sridharan G; Department of Molecular Microbiology and Immunology, Johns Hopkins; School of Hygiene and Public Health, Baltimore, Maryland 21205, USA.; Chemokines have been implicated as protective factors against human immunodeficiency virus (HIV) infection, competing for binding to receptors that also function as coreceptors for HIV. In this study of HIV-positive donors, peripheral blood mononuclear cell (PBMC) culture resistance to endogenous and exogenous HIV cor
Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor.: J Infect Dis. 1997 Nov;176(5):1175-9. Unique Identifier : AIDSLINE /MED98022674; Al-Harthi L; Roebuck KA; Kessler H; Landay A; Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's; Medical Center, Chicago, Illinois 60612-3833, USA.; Protease inhibitors block virus maturation and prevent the spread of human immunodeficiency virus (HIV)-1 in vitro. HIV-1-positive persons produce higher levels of proinflammatory cytokines that up-regulate HIV-1 replication. For the protease inhibitor to be effective in vivo, it must be able to suppress cytokine-indu
Augmented serum neutralizing activity against primary human immunodeficiency virus type 1 (HIV-1) isolates in two groups of HIV-1-infected long-term nonprogressors.: J Infect Dis. 1997 Nov;176(5):1180-7. Unique Identifier : AIDSLINE /MED98022675; Zhang YJ; Fracasso C; Fiore JR; Bjorndal A; Angarano G; Gringeri A; Fenyo EM; Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm,; Sweden.; Neutralizing activity against primary human immunodeficiency virus type 1 (HIV-1) isolates from 17 persons who were long-term disease nonprogressors (LTNPs) and 13 persons who were fast progressors (FPs) was compared. Sera from LTNPs showed higher neutralizing activity both in titer and in host spectrum than did sera
Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaques.: J Infect Dis. 1997 Nov;176(5):1188-97. Unique Identifier : AIDSLINE /MED98022676; Kent SJ; Woodward A; Zhao A; Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria,; Australia.; Macaca nemestrina efficiently control acute human immunodeficiency virus type 1 (HIV-1) infection. The roles of helper (Th) and cytotoxic (CTL) T cells in controlling acute HIV-1 infection in both peripheral blood and lymph node mononuclear cells (PBMC and LNMC) were assessed in this model. Th and CTL responses to HIV
Simian immunodeficiency virus burden in tissues and cellular compartments during clinical latency and AIDS.: J Infect Dis. 1997 Nov;176(5):1198-208. Unique Identifier : AIDSLINE /MED98022677; Reinhart TA; Rogan MJ; Huddleston D; Rausch DM; Eiden LE; Haase AT; Department of Microbiology, University of Minnesota Medical School,; Minneapolis 55455, USA.; In the course of human immunodeficiency virus infection or of the related simian immunodeficiency virus (SIV), progression to AIDS is associated with high virus burdens in blood. How virus burden in the bloodstream is related to virus burden in tissue reservoirs was addressed in an animal model of rhesus macaques infe
A randomized evaluation of ethambutol for prevention of relapse and drug resistance during treatment of Mycobacterium avium complex bacteremia with clarithromycin-based combination therapy. California Collaborative Treatment Group.: J Infect Dis. 1997 Nov;176(5):1225-32. Unique Identifier : AIDSLINE /MED98022680; Dube MP; Sattler FR; Torriani FJ; See D; Havlir DV; Kemper CA; Dezfuli MG; Bozzette SA; Bartok AE; Leedom JM; Tilles JG; McCutchan JA; University of Southern California School of Medicine, Los Angeles,; USA.; Patients with AIDS and Mycobacterium avium complex (MAC) bacteremia are at high risk for relapse and emergence of resistant isolates during monotherapy with clarithromycin. Ninety-five AIDS patients with MAC bacteremia received clarithromycin plus clofazimine, with or without ethambutol, in a prospective, multicenter,
Review: the immune response in human tuberculosis--implications for tuberculosis control.: J Infect Dis. 1997 Nov;176(5):1351-9. Unique Identifier : AIDSLINE /MED98022696; Ellner JJ; Department of Medicine, Case Western Reserve University and University; Hospitals, Cleveland, Ohio 44106-4984, USA.
The 30-bp deletion variant of Epstein-Barr virus-encoded latent membrane protein-1 prevails in acute infectious mononucleosis.: J Infect Dis. 1997 Nov;176(5):1370-3. Unique Identifier : AIDSLINE /MED98022699; Berger C; McQuain C; Sullivan JL; Nadal D; Quesenberry PJ; Knecht H; Department of Pediatrics, University of Massachusetts Medical Center,; Worcester 01655-0246, USA.; To assess the frequency of malignancy-associated 30-bp deletion variants of the latent membrane protein 1 (LMP-1) in benign conditions, a comparative sequence analysis was done using samples from 20 American children with acute infectious mononucleosis and 16 Swiss children with chronic tonsillar hyperplasia. The 30-b
Lymph node expansion of CD4+ lymphocytes during antiretroviral therapy.: J Infect Dis. 1997 Nov;176(5):1378-82. Unique Identifier : AIDSLINE /MED98022701; Lafeuillade A; Chouraqui M; Hittinger G; Poggi C; Delbeke E; Department of Infectious Diseases, General Hospital, Toulon, France.; The evolution of lymphocyte subsets was analyzed in sequential lymph nodes (LN) biopsies and compared with that in the blood of 25 human immunodeficiency virus type 1 (HIV-1)-infected patients receiving highly active antiretroviral therapy. An average of 3 biopsies were obtained from each patient, with a mean follow-u
Temporal relationship between human immunodeficiency virus type 1 RNA levels in serum and cellular infectious load in peripheral blood.: J Infect Dis. 1997 Nov;176(5):1383-7. Unique Identifier : AIDSLINE /MED98022702; Blaak H; de Wolf F; van 't Wout AB; Pakker NG; Bakker M; Goudsmit J; Schuitemaker H; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service, University of; Amsterdam.; Cross-sectional analysis of 252 paired serum and peripheral blood mononuclear cell (PBMC) samples derived from 54 human immunodeficiency virus type 1 (HIV-1)-infected persons revealed a correlation between HIV-1 RNA load in serum and infectious load in peripheral CD4 T cells after 18 months of follow-up and before an
Correlation of virus load in plasma and lymph node tissue in human immunodeficiency virus infection. INCAS Study Group. Italy, Netherlands, Canada, Australia, and (United) States.: J Infect Dis. 1997 Nov;176(5):1388-92. Unique Identifier : AIDSLINE /MED98022703; Harris M; Patenaude P; Cooperberg P; Filipenko D; Thorne A; Raboud J; Rae S; Dailey P; Chernoff D; Todd J; Conway B; Montaner JS; Pathology Department, St. Paul's Hospital, University of British; Columbia, Vancouver, Canada.; The impact of long-term changes in plasma viremia, produced by effective combination antiretroviral therapy, on human immunodeficiency virus (HIV) burden within tissue reservoirs is unknown. Fifteen patients who had received at least 1 year of therapy with two or three drug combinations of zidovudine, didanosine, and
Zidovudine-resistant human immunodeficiency virus type 1 strains subcultured in the presence of both lamivudine and quinoxaline HBY 097 retain marked sensitivity to HBY 097 but not to lamivudine.: J Infect Dis. 1997 Nov;176(5):1392-7. Unique Identifier : AIDSLINE /MED98022704; Balzarini J; Pelemans H; Riess G; Roesner M; Winkler I; De Clercq E; Kleim JP; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; Replication of zidovudine-resistant human immunodeficiency virus type 1 (HIV-1) strains (containing the 41 Met-->Leu and 215 Thr-->Tyr mutations in reverse transcriptase [RT]) was inhibited to a significantly greater extent by the combination of lamivudine and quinoxaline HBY 097 than by either drug alone or even full
Syphilis serology in human immunodeficiency virus infection: evidence for false-negative fluorescent treponemal testing.: J Infect Dis. 1997 Nov;176(5):1397-400. Unique Identifier : AIDSLINE /MED98022705; Erbelding EJ; Vlahov D; Nelson KE; Rompalo AM; Cohn S; Sanchez P; Quinn TC; Brathwaite W; Thomas DL; Department of Medicine, Johns Hopkins University School of Medicine; and School of Hygiene and Public Health, Baltimore, Maryland 21205,; USA.; Injection drug users were assessed serologically for human immunodeficiency virus infection and syphilis every 6 months. Treatment histories were reviewed for any high-titer biologic false-positive (BFP) reactors, that is, persons with rapid plasma reagin (RPR) titers > or = 1:4 and negative results for fluorescent tr
Neutralization assays using the BZ167 strain of human immunodeficiency virus type 1 [letter]: J Infect Dis. 1997 Nov;176(5):1410-2. Unique Identifier : AIDSLINE /MED98022708; Moore JP; Montefiori DC
Does prior tuberculosis protect human immunodeficiency virus-infected persons from Mycobacterium avium complex disease? [letter]: J Infect Dis. 1997 Nov;176(5):1412-3. Unique Identifier : AIDSLINE /MED98022709; Collazos J
Serum vitamin E decreases in HIV-seropositive subjects over time.: J Lab Clin Med. 1997 Sep;130(3):293-6. Unique Identifier : AIDSLINE /MED98000036; Pacht ER; Diaz P; Clanton T; Hart J; Gadek JE; Department of Internal Medicine, The Ohio State University Medical; Center, Columbus, USA.; Vitamin E is an important lipid soluble antioxidant that has a number of crucial functions including protecting lipids from oxidative damage. It also may play an important role in enhancing the immune response in subjects with Human Immunodeficiency Virus HIV) infection. The current study measured the serum level of v
Microorganisms and their interaction with the immune system.: J Leukoc Biol. 1997 Oct;62(4):415-29. Unique Identifier : AIDSLINE /MED97474286; Kotwal GJ; Department of Microbiology and Immunology, University of Louisville; School of Medicine, Kentucky 40292, USA.; Microorganisms interact with the immune system in multiple ways. In an interaction between a microorganism and its host, the defense of the host does not go unchallenged. Microorganisms have for decades been suspected of possessing the capabilities of hiding from and escaping the consequences of immune surveillance. E
Initiation codon scanthrough versus termination codon readthrough demonstrates strong potential for major histocompatibility complex class I-restricted cryptic epitope expression.: J Exp Med. 1997 Oct 6;186(7):1051-8. Unique Identifier : AIDSLINE /MED97461591; Bullock TN; Patterson AE; Franlin LL; Notidis E; Eisenlohr LC; Department of Microbiology and Immunology, Kimmel Cancer Center,; Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.; Accumulating evidence shows that the repertoire of major histocompatibility complex class I-restricted epitopes extends beyond conventional translation reading frames. Previously, we reported that scanthrough translation, where the initiating AUG of a primary open reading frame is bypassed, is most likely to account f
Two novel routes of transporter associated with antigen processing (TAP)-independent major histocompatibility complex class I antigen processing.: J Exp Med. 1997 Oct 6;186(7):1087-98. Unique Identifier : AIDSLINE /MED97461594; Snyder HL; Bacik I; Bennink JR; Kearns G; Behrens TW; Bachi T; Orlowski M; Yewdell JW; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892-0440, USA.; Jaw1 is an endoplasmic reticulum (ER) resident protein representative of a class of proteins post translationally inserted into membranes via a type II membrane anchor (cytosolic NH2 domain, lumenal COOH domain) in a translocon-independent manner. We found that Jaw1 can efficiently deliver a COOH-terminal antigenic pe
Peripheral selection of T cell repertoires: the role of continuous thymus output.: J Exp Med. 1997 Oct 6;186(7):1099-106. Unique Identifier : AIDSLINE /MED97461595; Tanchot C; Rocha B; U345 Institut National de la Sante et de la Recherche Medicale,; Institut Necker, 156, 75730 Paris Cedex 15, France.; We investigated the role of continuous thymus output in the shaping of mature T cell repertoires by studying in vivo the survival of a single clone of mature Rag2-deficient T cell receptor (TCR) transgenic cells at different stages of activation in the absence or presence of thymus export. In the absence of thymus exp
Role of interleukin 12 and costimulators in T cell anergy in vivo.: J Exp Med. 1997 Oct 6;186(7):1119-28. Unique Identifier : AIDSLINE /MED97461597; Parijs LV; Perez VL; Biuckians A; Maki RG; London CA; Abbas AK; Immunology Research Division, Department of Pathology, Brigham &; Women's Hospital and Harvard Medical School, Boston, Massachusetts; 02115, USA.; The induction of T cell anergy in vivo is thought to result from antigen recognition in the absence of co-stimulation and inflammation, and is associated with a block in T cell proliferation and Th1 differentiation. Here we have examined the role of interleukin (IL)-12, a potent inducer of Th1 responses, in regulating
Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major.: J Exp Med. 1997 Oct 6;186(7):1137-47. Unique Identifier : AIDSLINE /MED97461599; Gurunathan S; Sacks DL; Brown DR; Reiner SL; Charest H; Glaichenhaus N; Seder RA; Lymphokine Regulation Unit, Laboratory of Clinical Investigation,; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892, USA.; To determine whether DNA immunization could elicit protective immunity to Leishmania major in susceptible BALB/c mice, cDNA for the cloned Leishmania antigen LACK was inserted into a euykaryotic expression vector downstream to the cytomegalovirus promoter. Susceptible BALB/c mice w
How many thymocytes audition for selection?: J Exp Med. 1997 Oct 6;186(7):1149-58. Unique Identifier : AIDSLINE /MED97461600; Merkenschlager M; Graf D; Lovatt M; Bommhardt U; Zamoyska R; Fisher AG; Lymphocyte Development Group, Medical Research Council Clinical; Sciences Centre, Royal Postgraduate Medical School, Hammersmith; Hospital, London W12 0NN, United Kingdom. mmerkens@rpms.ac.uk; T cell maturation requires the rearrangement of clonotypic T cell receptors (TCR) capable of interacting with major histocompatibility complex (MHC) ligands to initiate positive and negative selection. Only 3-5% of thymocytes mature to join the peripheral T cell pool. To investigate the basis for this low success rate
Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95.: J Exp Med. 1997 Oct 6;186(7):1171-6. Unique Identifier : AIDSLINE /MED97461603; Wang J; Lenardo MJ; Laboratory of Immunology, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892-1892, USA.; B cells are susceptible to Fas ligand (FasL)+ CD4(+) Th1 cell-mediated apoptosis. We demonstrate that blocking the interactions between lymphocyte function associated (LFA)-1 and intercellular adhesion molecule(ICAM)-1 and ICAM-2 completely suppresses Fas-dependent B cell lysis. Antibodies to CD2 and CD48 partially su
Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice.: J Exp Med. 1997 Oct 6;186(7):989-97. Unique Identifier : AIDSLINE /MED97461586; Kagi D; Odermatt B; Seiler P; Zinkernagel RM; Mak TW; Hengartner H; Ontario Cancer Institute, Toronto M5G2M9, Canada. dkagi@amgen.com; To investigate the role of T cell-mediated, perforin-dependent cytotoxicity in autoimmune diabetes, perforin-deficient mice were backcrossed with the nonobese diabetes mouse strain. It was found that the incidence of spontaneous diabetes over a 1 yr period was reduced from 77% in perforin +/+ control to 16% in perfori
Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization.: J Exp Med. 1997 Oct 20;186(8):1287-98. Unique Identifier : AIDSLINE /MED97477412; Ugolini S; Mondor I; Parren PW; Burton DR; Tilley SA; Klasse PJ; Sattentau QJ; Centre d'Immunologie de Marseille-Luminy, France.; Antibody-mediated neutralization of human immunodeficiency virus type-1 (HIV-1) is thought to function by at least two distinct mechanisms: inhibition of virus-receptor binding, and interference with events after binding, such as virus-cell membrane fusion. Here we show, by the use of a novel virus-cell binding assay,
Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection.: J Exp Med. 1997 Oct 20;186(8):1365-72. Unique Identifier : AIDSLINE /MED97477420; Katsikis PD; Garcia-Ojeda ME; Torres-Roca JF; Tijoe IM; Smith CA; Herzenberg LA; Herzenberg LA; Department of Genetics, Stanford University School of Medicine,; California 94305, USA. katsikis@auhs.edu; Apoptosis of peripheral blood T cells has been suggested to play an important role in the pathogenesis of human immunodeficiency virus (HIV) infection. Spontaneous, Fas (CD95)-induced and activation-induced T cell apoptosis have all been described in peripheral blood mononuclear cell cultures of HIV-infected individua
Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding.: J Exp Med. 1997 Oct 20;186(8):1373-81. Unique Identifier : AIDSLINE /MED97477421; Wu L; LaRosa G; Kassam N; Gordon CJ; Heath H; Ruffing N; Chen H; Humblias J; Samson M; Parmentier M; Moore JP; Mackay CR; LeukoSite, Inc., Cambridge, Massachusetts 02142, USA.; lijun_wu@leukosite.com; CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic strains of HIV-1. To understand the molecular basis of the binding of chemokines and HIV-1 to CCR5, we developed a number of mAbs that inhibit the various interactions of CCR5,
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4.: J Exp Med. 1997 Oct 20;186(8):1383-8. Unique Identifier : AIDSLINE /MED97477422; Schols D; Struyf S; Van Damme J; Este JA; Henson G; De Clercq E; Laboratory of Experimental Chemotherapy, Rega Institute for Medical; Research, Leuven, Belgium. dominique.schols@rega.kuleuven.ac.be; Bicyclams are a novel class of antiviral compounds that are highly potent and selective inhibitors of the replication of HIV-1 and HIV-2. Surprisingly, however, when the prototype compound AMD3100 was tested against M-tropic virus strains such as BaL, ADA, JR-CSF, and SF-162 in human peripheral blood mononuclear cells
A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection.: J Exp Med. 1997 Oct 20;186(8):1389-93. Unique Identifier : AIDSLINE /MED97477423; Murakami T; Nakajima T; Koyanagi Y; Tachibana K; Fujii N; Tamamura H; Yoshida N; Waki M; Matsumoto A; Yoshie O; Kishimoto T; Yamamoto N; Nagasawa T; Department of Microbiology, Tokyo Medical and Dental University School; of Medicine, Japan.; Several members of the chemokine receptor family have been shown to function in association with CD4 to permit human immunodeficiency virus type 1 (HIV-1) entry and infection. The CXC chemokine receptor CXCR4/fusin is a receptor for pre-B cell growth stimulating factor (PBSF)/stromal cell-derived factor 1 SDF-1) and s
A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor.: J Exp Med. 1997 Oct 20;186(8):1395-400. Unique Identifier : AIDSLINE /MED97477424; Doranz BJ; Grovit-Ferbas K; Sharron MP; Mao SH; Goetz MB; Daar ES; Doms RW; O'Brien WA; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; The chemokine receptor CXCR4 is the major coreceptor used for cellular entry by T cell- tropic human immunodeficiency virus HIV)-1 strains, whereas CCR5 is used by macrophage (M)-tropic strains. Here we show that a small-molecule inhibitor, ALX40-4C, inhibits HIV-1 envelope (Env)-mediated membrane fusion and viral ent
Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression.: J Exp Med. 1997 Nov 3;186(9):1535-46. Unique Identifier : AIDSLINE /MED98012227; Giese NA; Gabriele L; Doherty TM; Klinman DM; Tadesse-Heath L; Contursi C; Epstein SL; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-0760, USA. ngiese@atlas.niaid.nih.gov; Mice with a null mutation of the gene encoding interferon consensus sequence-binding protein (ICSBP) develop a chronic myelogenous leukemia-like syndrome and mount impaired responses to certain viral and bacterial infections. To gain a mechanistic understanding of the contributions of ICSBP to humoral and cellular imm
Women's health care for the coming millennium.: J Fla Med Assoc. 1997 Aug-Sep;84(6):358-63. Unique Identifier : AIDSLINE /MED98021532; Foster HW Jr; Meharry Medical College, Nashville, Tennessee, USA.; In examining ways to improve female health care access and utilization, the magnitude of health problems must be examined before the design of solutions. Two types of barriers interfere with health care: attitudinal barriers blocking motivation to seek health care services and organizational barriers which block actua
Inhibition of human immunodeficiency virus type 1 particle formation by alterations of defined amino acids within the C terminus of the capsid protein.: J Gen Virol. 1997 Oct;78 ( Pt 10):2489-96. Unique Identifier : AIDSLINE /MED98007625; Kattenbeck B; von Poblotzki A; Rohrhofer A; Wolf H; Modrow S; Institut fur Medizinische Mikrobiologie und Hygiene, Universitat; Regensburg, Germany.; In previous studies, we demonstrated that the substitution of amino acid triplets for alanines in the carboxy-terminal portion amino acids 341-352: ATL EEM MTA CQC) of the capsid protein domain (p24) of human immunodeficiency virus type 1 (HIV-1) partly led to an inhibitory effect on the capacity to form virus-like pa
Generation of infectious virus particles by transient co-expression of human immunodeficiency virus type 1 gag mutants.: J Gen Virol. 1997 Oct;78 ( Pt 10):2497-501. Unique Identifier : AIDSLINE /MED98007626; Chen YL; Ts'ai PW; Yang CC; Wang CT; Institute of Clinical Medicine, National Yang-Ming University, and; Department of Medical Research and Education, Veterans General; Hospital-Taipei, Taiwan, Republic of China.; We have demonstrated that COS7 cells transiently co-expressing myristylation-defective (Myr-) and protease-defective (PR-) human immunodeficiency virus (HIV) mutants can release infectious virions when co-transfected with an amphotropic murine leukaemia virus envelope protein expression plasmid (SV-A-MLV-env). In cont
Expression of naturally occurring antisense RNA inhibits human immunodeficiency virus type 1 heterologous strain replication.: J Gen Virol. 1997 Oct;78 ( Pt 10):2503-11. Unique Identifier : AIDSLINE /MED98007627; Tagieva NE; Vaquero C; Institut Cochin de Genetique Moleculaire, Paris, France.; Recently, the presence of human immunodeficiency virus type 1 HIV-1) RNA transcripts with negative-strand polarity has been shown in tissue culture models of acute and persistently infected cells. One of these transcripts encodes a 189 amino acid open reading frame. This highly conserved antisense sequence is compleme
Syncytium formation induced by human immunodeficiency virus type 1 isolates correlates with affinity for CD4.: J Gen Virol. 1997 Oct;78 ( Pt 10):2513-22. Unique Identifier : AIDSLINE /MED98007628; Watkins BA; Crowley R; Davis AE; Louie AT; Reitz MS Jr; Division of Basic Sciences, National Cancer Institute, National; Institutes of Health, Bethesda, MD 20892, USA. bawatkins@earthlink.net; Different strains of human immunodeficiency virus type 1 (HIV-1) show considerable divergence in genetic content and biological properties. One property that has been closely correlated with clinical prognosis is the ability to induce syncytia formation in susceptible cells. This ability had been correlated with the V
No reactivation of attenuated immunodeficiency viruses in rhesus macaques after vaccinia virus-induced immune activation.: J Gen Virol. 1997 Oct;78 ( Pt 10):2523-8. Unique Identifier : AIDSLINE /MED98007629; Dittmer U; Nisslein T; Meyerhans A; Hunsmann G; Stahl-Hennig C; Deutsches Primatenzentrum, Virologie und Immunologie, Gottingen,; Germany. udittmer@atlas.niaid.nih.gov; Live-attenuated simian immunodeficiency virus (SIV) protects macaques against challenge with pathogenic SIV. To evaluate the safety of such vaccines, an investigation of whether or not nef-deleted SIV could be reactivated in vivo by immune activation of the host was conducted. In addition, monkeys infected with apatho
Live attenuated simian immunodeficiency virus prevents super-infection by cloned SIVmac251 in cynomolgus monkeys.: J Gen Virol. 1997 Oct;78 ( Pt 10):2529-39. Unique Identifier : AIDSLINE /MED98007630; Titti F; Sernicola L; Geraci A; Panzini G; Di Fabio S; Belli R; Monardo F; Borsetti A; Maggiorella MT; Koanga-Mogtomo M; Corrias F; Zamarchi R; Amadori A; Chieco-Bianchi L; Verani P; Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.; The ability of a live attenuated simian immunodeficiency virus SIV) to protect against challenge with cloned SIVmac251/BK28 was evaluated in four cynomolgus macaques. The intravenous infection of the C8 variant of the SIVmac251/32H virus, carrying an in-frame 12 bp deletion in the nef gene, did not affect the CD4+ and
Elevation of cytokines associated with the thrombocytopenia of equine infectious anaemia.: J Gen Virol. 1997 Oct;78 ( Pt 10):2541-8. Unique Identifier : AIDSLINE /MED98007631; Tornquist SJ; Oaks JL; Crawford TB; Department of Veterinary Microbiology and Pathology, Washington State; University, Pullman 99164-7040, USA. tornquis@ccmail.orst.edu; Thrombocytopenia is a common finding in infection with equine infectious anaemia virus (EIAV), a lentivirus with some homology to human immunodeficiency virus (HIV). The thrombocytopenia of EIA, like that in some HIV patients, appears to have a multifactorial pathogenesis. To investigate the decreased platelet product
Comparison of the complete sequence of feline spumavirus with those of the primate spumaviruses reveals a shorter gag gene.: J Gen Virol. 1997 Oct;78 ( Pt 10):2549-64. Unique Identifier : AIDSLINE /MED98007632; Helps CR; Harbour DA; Department of Clinical Veterinary Science, University of Bristol,; Langford, UK.; The complete nucleotide sequence of the provirus of feline foamy virus (FeFV), strain F-17, was determined, and compared to the available data for human and simian spumaviruses. In addition to the usual retroviral gag, pol and env genes, two open reading frames are present between the env gene and the 3 -LTR, as in th
Interleukin 4 stimulates infection and temporary growth of human neonatal lymphocytes exposed in vitro to human T-lymphotropic virus type I, but fails to substitute for interleukin 2 in the immortalization of infected cultures.: J Gen Virol. 1997 Oct;78 ( Pt 10):2565-74. Unique Identifier : AIDSLINE /MED98007633; Mastino A; Grelli S; Favalli C; Matteucci C; De Carli M; Garaci E; Macchi B; Institute of Microbiology, Faculty of Science, University of Messina,; Italy.; It has been shown that interleukin 4 (IL-4) stimulates the proliferation of cells from patients affected by adult T-cell leukaemia, the haematological malignancy aetiologically associated with human T-lymphotropic virus type I (HTLV-I). In the present study, human neonatal lymphocytes were exposed to HTLV-I in vitro i
Spliced human endogenous retroviral HERV-H env transcripts in T-cell leukaemia cell lines and normal leukocytes: alternative splicing pattern of HERV-H transcripts.: J Gen Virol. 1997 Oct;78 ( Pt 10):2575-85. Unique Identifier : AIDSLINE /MED98007634; Lindeskog M; Blomberg J; Department of Medical Microbiology, Lund University, Sweden.; mats.lindeskog@mmb.lu.se; The majority of human endogenous retroviral HERV-H elements in the human genome have large deletions in pol and lack most of env, 5-10% are more or less complete with a potentially immunosuppressive transmembrane protein-encoding env region. Spliced HERV-H env transcripts were detected in T-cell leukaemia cell lines a
Inhibition of murine leukaemia virus retrotranscription by the intracellular expression of a phage-derived anti-reverse transcriptase antibody fragment.: J Gen Virol. 1997 Oct;78 ( Pt 10):2591-9. Unique Identifier : AIDSLINE /MED98007636; Gargano N; Cattaneo A; MRC Laboratory of Molecular Biology, Cambridge, UK.; The intracellular targeting of recombinant antibodies is an experimental strategy to interfere with the function of selected molecules that is being utilized in a variety of different systems for research and medical applications. Since recombinant antibodies are increasingly being derived from phage display libraries
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.: J Nat Prod. 1997 Sep;60(9):884-8. Unique Identifier : AIDSLINE /MED97463579; Lin YM; Anderson H; Flavin MT; Pai YH; Mata-Greenwood E; Pengsuparp T; Pezzuto JM; Schinazi RF; Hughes SH; Chen FC; MediChem Research, Inc., Lemont, Illinois 60439, USA.; Eleven biflavonoids, including amentoflavone (1), agathisflavone 2), robustaflavone (3), hinokiflavone (4), volkensiflavone (5), morelloflavone (7), rhusflavanone (9), succedaneaflavanone (10), GB-1a (11), GB-1a 7 -O-beta-glucoside (13), and GB-2a (14) isolated from Rhus succedanea and Garcinia multiflora, as well as
Proton MRS and quantitative MRI assessment of the short term neurological response to antiretroviral therapy in AIDS.: J Neurol Neurosurg Psychiatry. 1997 Oct;63(4):477-82. Unique Identifier : AIDSLINE /MED98001292; Wilkinson ID; Lunn S; Miszkiel KA; Miller RF; Paley MN; Williams I; Chinn RJ; Hall-Craggs MA; Newman SP; Kendall BE; Harrison MJ; Department of Medical Physics and Bioengineering, The Middlesex; Hospital, University College London Hospitals NHS Trust, UK.; OBJECTIVE: To investigate MRI and proton spectroscopy changes in five patients with HIV associated dementia complex (HADC) treated with antiretroviral therapy. METHODS: Three markers were evaluated: (1) CSF/intracranial volume ratio; (2) T2 weighted signal ratio between parieto-occ
Association between HIV distal symmetric polyneuropathy and Mycobacterium avium complex infection [letter]: J Neurol Neurosurg Psychiatry. 1997 Oct;63(4):557. Unique Identifier : AIDSLINE /MED98001321; Woolley I; Faragher M; Spelman D
Successful application of pentoxifylline in the treatment of HTLV-I associated myelopathy.: J Neurol Sci. 1997 Oct 3;151(1):97-101. Unique Identifier : AIDSLINE /MED97475506; Shirabe S; Nakamura T; Tsujino A; Nishiura Y; Furuya T; Goto H; Suenaga A; Nakane S; Yoshimura T; Nagataki S; First Department of Internal Medicine, Nagasaki University School of; Medicine, Japan.; Fifteen patients with human T-cell lymphotropic virus type-I HTLV-I)-associated myelopathy (HAM) were treated in an uncontrolled preliminary trial by oral administration of pentoxifylline (PTX). Motor function, neurological evaluation, immunological markers and parameters were evaluated after four weeks. In 13 of the
Acute polyradiculopathies in HIV-infected patients.: J Neurol. 1997 Aug;244(8):499-504. Unique Identifier : AIDSLINE /MED97455173; Corral I; Quereda C; Casado JL; Cobo J; Navas E; Perez-Elias MJ; Pintado V; Fortun J; Guerrero A; Servicio de Neurologia, Hospital Ramon Y Cajal, Madrid, Spain.; We studied 17 consecutive cases of acute polyradiculopathy (PR) diagnosed in HIV-infected patients to investigate the possible causes of this syndrome in our milieu. Sixteen patients presented with lumbosacral PR and one patient had predominantly cervical PR. Electrophysiological study showed a predominantly motor axo
PET scanning and the human immunodeficiency virus-positive patient.: J Nucl Med. 1997 Oct;38(10):1575-83. Unique Identifier : AIDSLINE /MED98021748; O'Doherty MJ; Barrington SF; Campbell M; Lowe J; Bradbeer CS; Clinical PET Centre, Guys and St. Thomas Hospital Trust, St. Thomas'; Hospital, London, United Kingdom.; The use of PET scanning in patients with human immunodeficiency virus infection and fever of unknown origin, confusion and/or weight loss was investigated. METHODS: Eighty patients were examined using PET. Fifty-seven patients had half-body scans with [18F]fluorodeoxyglucose (FDG), and 23 patients had brain studies pe
[Informational needs and information-seeking behaviors of recently diagnosed HIV seropositive gay man]: Hu Li Tsa Chih. 1997 Jun;44(3):32-40. Unique Identifier : AIDSLINE /MED98028979; Ko NY; Shiau C; Sheu SL; In recent years, substantial changes in doctor-patient relations and consumer oriented attitudes have occurred. Many patients need more information regarding their diagnosis and treatment for developing positive coping strategies to face their disease. This case report uses an informational needs theoretical framework
More sensitive immune complex transfer enzyme immunoassay for antibody IgG to p17 of HIV-1 with shorter incubation time for immunoreactions and larger volumes of serum samples.: J Clin Lab Anal. 1997;11(5):244-50. Unique Identifier : AIDSLINE /MED97437858; Ishikawa S; Hashida S; Hashinaka K; Kojima M; Saito A; Takamizawa A; Shinagawa H; Oka S; Shimada K; Ishikawa E; Department of Biochemistry, Miyazaki Medical College, Japan.; In the previous immune complex transfer enzyme immunoassay for antibody IgG to p17 of HIV-1, the immune complex comprising 2,4-dinitrophenyl-bovine serum albumin-recombinant p17 conjugate, anti-p17 IgG, and recombinant p17-beta-D-galactosidase conjugate was trapped onto polystyrene beads coated with anti-2,4-dinitroph
More reliable diagnosis of infection with human immunodeficiency virus type 1 (HIV-1) by detection of antibody IgGs to pol and gag proteins of HIV-1 and p24 antigen of HIV-1 in urine, saliva, and/or serum with highly sensitive and specific enzyme immunoassay (immune complex transfer enzyme immunoassay): a review.: J Clin Lab Anal. 1997;11(5):267-86. Unique Identifier : AIDSLINE /MED97437861; Hashida S; Hashinaka K; Ishikawa S; Ishikawa E; Department of Biochemistry, Miyazaki Medical College, Japan.; Ultrasensitive enzyme immunoassays (immune complex transfer enzyme immunoassays) were developed for antibody IgGs to HIV-1 using recombinant reverse transcriptase (rRT), p17 (rp17), and p24 (rp24) as antigens. Antibody IgGs were reacted with 2,4-dinitrophenyl-recombinant antigens and recombinant antigen-beta-D-galacto
Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8)--a new human tumour virus.: J Pathol. 1997 Jul;182(3):262-5. Unique Identifier : AIDSLINE /MED98009940; Brooks LA; Wilson AJ; Crook T; Department of Clinical Sciences, London School of Hygiene and Tropical; Medicine, U.K.; Recently, a novel DNA virus has been molecularly cloned from Kaposi s sarcoma (KS) tissue, a tumour common in acquired immune deficiency syndrome (AIDS). Analysis of the viral genome confirms that it is a relative of human herpesviruses and the virus has been designated HHV-8. Epidemiological evidence suggests a stron
Ultrastructural characterization of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in Kaposi's sarcoma lesions: electron microscopy permits distinction from cytomegalovirus CMV).: J Pathol. 1997 Jul;182(3):273-81. Unique Identifier : AIDSLINE /MED98009942; Said JW; Chien K; Tasaka T; Koeffler HP; Department of Pathology, UCLA School of Medicine, USA.; Kaposi s sarcoma (KS) has been shown by molecular techniques to be associated with infection with human herpesvirus 8 HHV8/KSHV), but specific ultrastructural characterization of the virus has been impaired by the frequent presence in these lesions of other herpesviruses, particularly
Evaluation of an interdisciplinary training program in palliative care: addressing the needs of rural and northern communities.: J Palliat Care. 1997 Autumn;13(3):5-12. Unique Identifier : AIDSLINE /MED98015538; Janson LK; Dudgeon D; Nelson F; Henteleff P; Balneaves L; Faculty of Health and Human Sciences, Edith Cowan University,; Churchlands, Western Australia.; Our study was a pilot test of an interdisciplinary training program in palliative care to improve the quality of care to terminally ill cancer and AIDS patients in rural and northern communities in Manitoba. The program involved two weeks of intense palliative care training for nurses, social workers, physicians, and
The integration of medical management with recovery.: J Psychoactive Drugs. 1997 Jul-Sep;29(3):233-7. Unique Identifier : AIDSLINE /MED97479773; Schulz JE; Department of Family Medicine, East Carolina University School of; Medicine, Greenville, North Carolina 27858-4354, USA.; Patients recovering from alcohol and other drug addiction have unique medical and pharmacological needs. Careful selection of medications call decrease the risk of relapse. Angiotensin-converting enzyme inhibitors and calcium channel-blocking medications are excellent choices to treat hypertension. Most gastrointestin
Periodontal status of HIV-1 and HIV-2 seropositive and HIV seronegative female commercial sex workers in Senegal.: J Periodontol. 1997 Sep;68(9):827-31. Unique Identifier : AIDSLINE /MED98021108; Ndiaye CF; Critchlow CW; Leggott PJ; Kiviat NB; Ndoye I; Robertson PB; Georgas KN; Department of Dentistry, University of Dakar, Senegal.; Comprehensive studies of 92 commercial sex workers in Senegal , Africa included an oral examination in which we obtained measurements of decayed, missing, and filled (DMF) teeth; plaque index; gingival index; recession; probing depth (PD); clinical attachment loss (CAL); and the pr
CD30+ lymphocytes in chronic gingivitis from HIV-positive patients: a pilot study.: J Periodontol. 1997 Sep;68(9):881-3. Unique Identifier : AIDSLINE /MED98021116; Gomez RS; de Souza PE; da Costa JE; Araujo NS; Department of Oral Surgery and Pathology, School of Dentistry, Minas; Gerais Federal University, Belo Horizonte, Brazil.; Th2 type lymphocytes are characterized by high expression of CD30 glycoprotein. Increased serum levels of CD30 and Th2 IL-4 producing T-cells are found during AIDS progression. Since HIV-positive patients are more susceptible to periodontal disease, quantitative analysis of positive cells for the CD30 receptor in chro
AIDS overseas. Personal glimpses of a worldwide epidemic.: J Christ Nurs. 1997 Summer;14(3):10. Unique Identifier : AIDSLINE /MED98029021; Gesto K; Valley Hospice in Steubenville, Ohio, USA.
Beyond broken dreams. A mother's journey through AIDS.: J Christ Nurs. 1997 Summer;14(3):11-4. Unique Identifier : AIDSLINE /MED98029022; Warden V; Sandin FC; First Baptist Church of McKinney, Texas, USA.
AIDS other victims: a story of courage and faith.: J Christ Nurs. 1997 Summer;14(3):15-8. Unique Identifier : AIDSLINE /MED98029023; Rubin M; Telemetry Unit, Frankford Hospital in Philadelphia, Pennsylvania, USA.
Christie Hinds's personal crusade fighting AIDS with faith, facts friendship [interview by Karen Schmidt]: J Christ Nurs. 1997 Summer;14(3):19-22. Unique Identifier : AIDSLINE /MED98029024; Hinds C
Robin's place.: J Christ Nurs. 1997 Summer;14(3):8-9. Unique Identifier : AIDSLINE /MED98029020; Ellerhorst-Ryan JM; Alliance Home Health Services, Cincinnati, Ohio, USA.
FK-506 and cyclosporin A potentiate the IgE antibody production by contact sensitization with hapten in mice.: J Pharmacol Exp Ther. 1997 Oct;283(1):321-7. Unique Identifier : AIDSLINE /MED97476088; Nagai H; Hiyama H; Matsuo A; Ueda Y; Inagaki N; Kawada K; Department of Pharmacology, Gifu Pharmaceutical University, Japan.; Five repeated topical applications of 2,4-dinitrofluorobenzene to the ears of BALB/c mice resulted in contact dermatitis on the ears as well as significant elevation in dinitrophenol-specific IgE antibody and total IgE in the serum. FK-506 and cyclosporin A inhibited the development of contact dermatitis in terms of s
In vitro lymphocyte proliferation test in the diagnosis of oral mucosal hypersensitivity reactions to dental amalgam.: J Oral Pathol Med. 1997 Sep;26(8):362-6. Unique Identifier : AIDSLINE /MED98021188; Laine J; Happonen RP; Vainio O; Kalimo K; Department of Oral Diseases, University Central Hospital of Turku,; Finland.; Patch testing was carried out in 23 patients with oral lichenoid lesions (OLL) topographically related to dental amalgam fillings. Twelve patients displayed positive reactions to several mercury compounds, whereas 11 patients were negative. An in vitro lymphocyte proliferation (LyPro) test was carried out using differ
Expression of ICAM-1 in implanted primary and metastatic squamous cell carcinomas in rats.: J Oral Pathol Med. 1997 Sep;26(8):371-6. Unique Identifier : AIDSLINE /MED98021190; Li X; Fujikura Y; Wang YH; Sawada T; Tokuda N; Lovely RS; Hayatsu Y; Fukumoto T; Shinozaki F; Department of Oral and Maxillofacial Surgery, Yamaguchi University; School of Medicine, Ube, Japan.; FF6 tumor cells are derived from a spontaneous rat squamous cell carcinoma (SCC) which originally arose in the facial skin of a DA rat. In this study, FF6 tumor cells were implanted into rat oral mucosa to establish an ex vivo metastatic model. We analyzed the expression of intercellular cell adhesion molecule-1 (ICAM
Fatigue, depression, and quality of life in HIV-positive men.: J Psychosoc Nurs Ment Health Serv. 1997 Sep;35(9):32-40. Unique Identifier : AIDSLINE /MED97443671; Walker K; McGown A; Jantos M; Anson J; Psychology Department, Faculty of Applied Science, University of; Canberra, Australia.; 1. Fatigue is a real symptom of HIV infection, and up to two thirds of clients with HIV report symptoms of depression. 2. Depression and fatigue, besides being closely related in HIV cases, have an adverse effect on quality of life. 3. Treating depression and underlying causes of fatigue will improve the quality of li
Kaposi's sarcoma and the new herpesvirus [editorial]: J Med Microbiol. 1997 Jun;46(6):433-5. Unique Identifier : AIDSLINE /MED98011273; Birley HD; Schultz TF
Relation between phylogeny of African green monkey CD4 genes and their respective simian immunodeficiency virus genes.: J Med Primatol. 1997 Jun;26(3):120-8. Unique Identifier : AIDSLINE /MED98017879; Fomsgaard A; Muller-Trutwin MC; Diop O; Hansen J; Mathiot C; Corbet S; Barre-Sinoussi F; Allan JS; Statens Serum Institut, Technical University of Denmark, Copenhagen,; Denmark. afo@ssi.dk; An apparent species-specific relatedness of SIVagm suggests a coevolution with their natural hosts. However, the exact species or subspecies classification of African green monkeys, AGM, is uncertain because current classification schemes rely on phenotype markers, while more definitive genetic data are lacking. In th
CD8+ cell-mediated immune responses: relation to disease resistance and susceptibility in lentivirus-infected primates.: J Med Primatol. 1997 Jun;26(3):129-38. Unique Identifier : AIDSLINE /MED98017880; Buijs L; Bogers WM; Eichberg JW; Heeney JL; Department of Virology, Biomedical Primate Research Centre, Rijswijk,; The Netherlands.; Immune responses mediated by CD8+ lymphocytes have been correlated with protection from HIV infection and disease progression in humans and nonhuman primates. The CD8+ cell population is heterogeneous in terms of biological function and phenotype. We have undertaken a review of the current state of knowledge of subtyp
A malignant astrocytoma containing simian virus 40 DNA in a macaque infected with simian immunodeficiency virus.: J Med Primatol. 1997 Jun;26(3):172-80. Unique Identifier : AIDSLINE /MED98017885; Hurley JP; Ilyinskii PO; Horvath CJ; Simon MA; Division of Comparative Pathology, New England Regional Primate; Research Center, Harvard Medical School, Southborough, Massachusetts; 01772-9102, USA.; Polyomaviruses have proven oncogenicity in nonhost experimental animals; however, studies concerning the association between human brain tumors and simian and human polyomaviruses have yielded inconclusive results. We examined the relationship of SV40 to a malignant astrocytoma found in the right frontal lobe of a pig
The story of second cancers in patients cured of testicular cancer: tarnishing success or burnishing irrelevance? [editorial; comment]: J Natl Cancer Inst. 1997 Oct 1;89(19):1394-5. Unique Identifier : AIDSLINE /MED97467696; Nichols CR; Loehrer PJ Sr
Jekyll and Hyde: a new license for thalidomide? [news]: J Natl Cancer Inst. 1997 Oct 15;89(20):1480-1. Unique Identifier : AIDSLINE /MED97477278; Saphir A
Using 3'-azido-2',3'-dideoxythymidine (AZT) to prevent perinatal human immunodeficiency virus transmission and risk of transplacental carcinogenesis [editorial; comment]: J Natl Cancer Inst. 1997 Nov 5;89(21):1566-7. Unique Identifier : AIDSLINE /MED98026472; Reggy AA; Rogers MF; Simonds RJ
Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys [see comments]: J Natl Cancer Inst. 1997 Nov 5;89(21):1602-8. Unique Identifier : AIDSLINE /MED98026481; Olivero OA; Anderson LM; Diwan BA; Haines DC; Harbaugh SW; Moskal TJ; Jones AB; Rice JM; Riggs CW; Logsdon D; Yuspa SH; Poirier MC; Division of Basic Sciences, National Cancer Institute, Bethesda, MD; 20892-4255, USA. olivero@pop.nci.nih.gov; BACKGROUND: When given during pregnancy, the drug 3 -azido-2 ,3 -dideoxythymidine ( AZT ) substantially reduces maternal-fetal transmission of human immunodeficiency virus type 1 (HIV-1). However, AZT has been shown to be carcinogenic in adult mice afte
Gp120 can revert antagonism at the glycine site of NMDA receptors mediating GABA release from cultured hippocampal neurons.: J Neurosci Res. 1997 Sep 15;49(6):732-8. Unique Identifier : AIDSLINE /MED97474236; Fontana G; Valenti L; Raiteri M; Institute of Pharmacology and Pharmacognosy, University of Genoa,; Italy.; The effects of the human immunodeficiency virus type 1 envelope protein gp120 on the release of GABA elicited by N-methyl-D-aspartate (NMDA) from rat hippocampal neurons in primary culture has been investigated. NMDA (1-300 microM) increased in a concentration-dependent manner (EC50 =37.9+/-12 microM) the release of [
Renal aspergilloma mimicking a tumor on ultrasonography.: J Ultrasound Med. 1997 Aug;16(8):555-7. Unique Identifier : AIDSLINE /MED97460830; Fung Y; Yeh HC; Department of Radiology, Mount Sinai Hospital, New York, NY 10029,; USA.
Parotid MALT lymphoma in HIV infected children.: J Ultrasound Med. 1997 Sep;16(9):615-7. Unique Identifier : AIDSLINE /MED97462998; Corr P; Vaithilingum M; Thejpal R; Jeena P; Department of Radiology, University of Natal, Durban, South Africa.; A retrospective review of 10 children with biopsy proved mucosa-associated lymphoid tissue lymphoma of the parotid glands demonstrated multifocal hypoechoic intraparotid nodules and cysts with punctate calcification on sonography. This was confirmed on computed tomographic examination. All children were seropositive f
A mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site.: J Virol. 1997 Nov;71(11):8124-32. Unique Identifier : AIDSLINE /MED98001327; Du Z; Ilyinskii PO; Lally K; Desrosiers RC; Engelman A; New England Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772, USA.; Sequences at the left terminus of U3 in the left long terminal repeat (LTR) and at the right terminus of U5 in the right LTR are important for integration of retroviral DNA. In the infectious pathogenic molecular clone of simian immunodeficiency virus strain mac239 (SIVmac239), 10 of the 12 terminal base pairs form an
Live, attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus.: J Virol. 1997 Nov;71(11):8141-8. Unique Identifier : AIDSLINE /MED98001329; Shibata R; Siemon C; Czajak SC; Desrosiers RC; Martin MA; Laboratory of Molecular Microbiology, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Three rhesus macaques, previously immunized with SIVdelta3 or SIVdelta2, each an attenuated derivative of SIVmac239, and two naive monkeys were challenged with 30,000 50% tissue culture infective doses of SHIV, an SIV/human immunodeficiency virus type 1 (HIV-1) chimeric virus bearing the dual-tropic envelope of HIV-1D
Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1.: J Virol. 1997 Nov;71(11):8195-203. Unique Identifier : AIDSLINE /MED98001335; Pelemans H; Esnouf R; Dunkler A; Parniak MA; Vandamme AM; Karlsson A; De Clercq E; Kleim JP; Balzarini J; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside reverse transcriptase RT)
Resistance to a drug blocking human immunodeficiency virus type 1 entry (RPR103611) is conferred by mutations in gp41.: J Virol. 1997 Nov;71(11):8230-6. Unique Identifier : AIDSLINE /MED98001339; Labrosse B; Pleskoff O; Sol N; Jones C; Henin Y; Alizon M; INSERM, Institut Cochin de Genetique Moleculaire, Paris, France.; A triterpene derived from betulinic acid (RPR103611) blocks human immunodeficiency virus type 1 (HIV-1) infection and fusion of CD4+ cells with cells expressing HIV-1 envelope proteins (gp120 and gp41), suggesting an effect on virus entry. This compound did not block infection by a subtype D HIV-1 strain (NDK) or cell
Usage of the coreceptors CCR-5, CCR-3, and CXCR-4 by primary and cell line-adapted human immunodeficiency virus type 2.: J Virol. 1997 Nov;71(11):8237-44. Unique Identifier : AIDSLINE /MED98001340; Sol N; Ferchal F; Braun J; Pleskoff O; Treboute C; Ansart I; Alizon M; INSERM, Institut Cochin de Genetique Moleculaire, Paris, France.; The chemokine receptors CCR-5 and CXCR-4, and possibly CCR-3, are the principal human immunodeficiency virus type 1 (HIV-1) coreceptors, apparently interacting with HIV-1 envelope, in association with CD4. Cell lines coexpressing CD4 and these chemokine receptors were infected with a panel of seven primary HIV-2 isola
High viral burden and rapid CD4+ cell depletion in human immunodeficiency virus type 1-infected SCID-hu mice suggest direct viral killing of thymocytes in vivo.: J Virol. 1997 Nov;71(11):8245-53. Unique Identifier : AIDSLINE /MED98001341; Jamieson BD; Uittenbogaart CH; Schmid I; Zack JA; Department of Medicine, UCLA School of Medicine and Jonsson; Comprehensive Cancer Center, Los Angeles, California 90095-1678, USA.; The mechanism of CD4+ cell loss in lymphoid organs is unknown. In this study, human immunodeficiency virus (HIV) infection of human fetal thymus/liver implants in severe combined immunodeficient mice was used to investigate the mechanism of HIV-induced depletion of CD4-bearing cells in vivo. The implants were assessed
Neutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and independent binding of virus to cells.: J Virol. 1997 Nov;71(11):8289-98. Unique Identifier : AIDSLINE /MED98001346; Valenzuela A; Blanco J; Krust B; Franco R; Hovanessian AG; Unite de Virologie et d'Immunologie Cellulaire, Institut Pasteur,; Paris, France.; The CD4 molecule is an essential receptor for human immunodeficiency virus type 1 (HIV-1) through high-affinity interactions with the viral external envelope glycoprotein gp120. Previously, neutralizing monoclonal antibodies (MAbs) specific to the third hypervariable domain of gp120 (the V3 loop) have been thought to
Studies of AIDS vaccination using an ex vivo feline immunodeficiency virus model: protection conferred by a fixed-cell vaccine against cell-free and cell-associated challenge differs in duration and is not easily boosted.: J Virol. 1997 Nov;71(11):8368-76. Unique Identifier : AIDSLINE /MED98001357; Matteucci D; Pistello M; Mazzetti P; Giannecchini S; Del Mauro D; Lonetti I; Zaccaro L; Pollera C; Specter S; Bendinelli M; Department of Biomedicine, University of Pisa, Italy.; Cats immunized with cells infected with a primary isolate of feline immunodeficiency virus (FIV) and fixed with paraformaldehyde were challenged with cell-free or cell-associated homologous virus obtained ex vivo. Complete protection was observed in animals challenged with cell-free virus 4 months after completion of
Virus-specific, CD8+ major histocompatibility complex class I-restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus-infected beta2-microglobulin-deficient mice.: J Virol. 1997 Nov;71(11):8392-6. Unique Identifier : AIDSLINE /MED98001360; Quinn DG; Zajac AJ; Hioe CE; Frelinger JA; Department of Microbiology and Immunology, Loyola University Chicago,; Maywood, Illinois 60153, USA.; Following infection with lymphocytic choriomeningitis virus LCMV), normal adult mice generate virus-specific, major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTL) which clear the virus after intraperitoneal infection or cause death following intracranial (i.c.) infection. We have inv
Promiscuous use of CC and CXC chemokine receptors in cell-to-cell fusion mediated by a human immunodeficiency virus type 2 envelope protein.: J Virol. 1997 Nov;71(11):8405-15. Unique Identifier : AIDSLINE /MED98001362; Bron R; Klasse PJ; Wilkinson D; Clapham PR; Pelchen-Matthews A; Power C; Wells TN; Kim J; Peiper SC; Hoxie JA; Marsh M; Department of Biochemistry, University College London, United Kingdom.; The CC chemokine receptors CCR5, CCR2, and CCR3 and the CXC chemokine receptor CXCR4 have been implicated as CD4-associated cofactors in the entry of primary and cell line-adapted human immunodeficiency virus type 1 (HIV-1) strains. CXCR4 is also a receptor for T-cell-line-adapted, CD4-independent strains of HIV-2. Wi
Mutational analysis of human immunodeficiency virus type 1 HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.: J Virol. 1997 Nov;71(11):8456-66. Unique Identifier : AIDSLINE /MED98001367; Kawano Y; Tanaka Y; Misawa N; Tanaka R; Kira JI; Kimura T; Fukushi M; Sano K; Goto T; Nakai M; Kobayashi T; Yamamoto N; Koyanagi Y; Department of Microbiology, Tokyo Medical and Dental University,; Japan.; Human immunodeficiency virus type 1 (HIV-1) accessory genes including nef, vif, and vpr are important factors that determine the replication and pathogenesis of HIV-1. The state of activation is also important for the replication of HIV-1. We evaluated the properties of nef-, vif-, and vpr-minus macrophage-tropic HIV-
Analysis of the murine leukemia virus R peptide: delineation of the molecular determinants which are important for its fusion inhibition activity.: J Virol. 1997 Nov;71(11):8490-6. Unique Identifier : AIDSLINE /MED98001371; Yang C; Compans RW; Department of Microbiology and Immunology, Emory University School of; Medicine, Atlanta, Georgia 30322, USA.; In previous studies, the C-terminal R peptide of the murine leukemia virus (MuLV) Env protein was shown to be a potent inhibitor of viral fusion activity. In the present study, we investigated the molecular determinants in the MuLV Env protein cytoplasmic tail which are important for the fusion inhibition activity of
The human T-cell leukemia virus type 1 Rex regulatory protein exhibits an impaired functionality in human lymphoblastoid Jurkat T cells.: J Virol. 1997 Nov;71(11):8514-21. Unique Identifier : AIDSLINE /MED98001374; Hamaia S; Casse H; Gazzolo L; Duc Dodon M; Immuno-Virologie Moleculaire et Cellulaire, UMR 5537, Centre National; de la Recherche Scientifique-Universite Claude Bernard Lyon I, Faculte; de Medecine, France.; The Rex protein of human T-cell leukemia virus type 1 (HTLV-1) intervenes in the posttranscriptional regulation of proviral gene expression. Its binding to the Rex response element (XRE) present in the 3 long terminal repeat ensures the coordinate cytoplasmic accumulation of spliced and unspliced forms of viral messe
Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.: J Virol. 1997 Nov;71(11):8522-30. Unique Identifier : AIDSLINE /MED98001375; Valentin H; Lemasson I; Hamaia S; Casse H; Konig S; Devaux C; Gazzolo L; Immuno-Virologie Moleculaire et Cellulaire (UMR 5537), CNRS-UCB Lyon; I, Faculte de Medecine Lyon-RTH, Laennec, France.; Recruitment and extravasation of T cells through the blood-brain barrier are favored by adhesion molecule-mediated interactions of circulating T cells with endothelial cells. Since a common pathological finding in human T-cell leukemia virus type 1 HTLV-1)-associated diseases is the infiltration of HTLV-1-infected T l
An adenovirus-simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge.: J Virol. 1997 Nov;71(11):8531-41. Unique Identifier : AIDSLINE /MED98001376; Buge SL; Richardson E; Alipanah S; Markham P; Cheng S; Kalyan N; Miller CJ; Lubeck M; Udem S; Eldridge J; Robert-Guroff M; Basic Research Laboratory, National Cancer Institute, Bethesda,; Maryland 20892, USA.; Six female rhesus macaques were immunized orally and intranasally at 0 weeks and intratracheally at 12 weeks with an adenovirus type 5 host range mutant (Ad5hr)-simian immunodeficiency virus SIVsm env recombinant and at 24 and 36 weeks with native SIVmac251 gp120 in Syntex adjuvant. Four macaques received the Ad5hr ve
A naturally arising mutation of a potential silencer of exon splicing in human immunodeficiency virus type 1 induces dominant aberrant splicing and arrests virus production.: J Virol. 1997 Nov;71(11):8542-51. Unique Identifier : AIDSLINE /MED98001377; Wentz MP; Moore BE; Cloyd MW; Berget SM; Donehower LA; Division of Molecular Virology, Baylor College of Medicine, Houston,; Texas 77030, USA.; We have isolated a naturally arising human immunodeficiency type 1 (HIV-1) mutant containing a point mutation within the env gene. The point mutation resulted in complete loss of balanced splicing, with dominant production of aberrant mRNAs. The aberrant RNAs arose via activation of normally cryptic splice sites flank
Immunoglobulin V(H) usage during primary infection of rhesus monkeys with chimeric simian-human immunodeficiency viruses.: J Virol. 1997 Nov;71(11):8582-91. Unique Identifier : AIDSLINE /MED98001381; Margolin DH; Reimann KA; Sodroski J; Karlsson GB; Tenner-Racz K; Racz P; Letvin NL; Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center,; Boston, Massachusetts 02215, USA.; It has been suggested that naive immunoglobulins encoded by the V(H)3 gene family interact aberrantly with human immunodeficiency virus type 1 (HIV-1) gp120 via a superantigenic epitope, causing initial expansion and eventual depletion of V(H)3-expressing B cells. However, this possibility has not been prospectively a
Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.: J Virol. 1997 Nov;71(11):8615-23. Unique Identifier : AIDSLINE /MED98001384; Cao H; Kanki P; Sankale JL; Dieng-Sarr A; Mazzara GP; Kalams SA; Korber B; Mboup S; Walker BD; AIDS Research Center and Infectious Disease Unit, Massachusetts; General Hospital and Harvard Medical School, Boston 02114, USA.; Despite recent advances in antiviral therapy for human immunodeficiency virus (HIV) infection, successful global intervention will require an effective vaccine. Expanding evidence suggests that cytotoxic T-lymphocyte (CTL) responses will be an important component of such a vaccine. The varying geographic distribution
Immunopathologic changes in the thymus during the acute stage of experimentally induced feline immunodeficiency virus infection in juvenile cats.: J Virol. 1997 Nov;71(11):8632-41. Unique Identifier : AIDSLINE /MED98001386; Woo JC; Dean GA; Pedersen NC; Moore PF; Department of Pathology, School of Veterinary Medicine, University of; California, Davis 95616, USA.; The feline thymus is a target organ and site of viral replication during the acute stage of feline immunodeficiency virus (FIV) infection. This was demonstrated by histologic, immunohistologic, flow cytometric, and virologic tests. Thymic lesions developed after 28 days postinoculation (p.i.) and included thymitis, pr
Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses.: J Virol. 1997 Nov;71(11):8642-56. Unique Identifier : AIDSLINE /MED98001387; Kuhmann SE; Platt EJ; Kozak SL; Kabat D; Department of Biochemistry and Molecular Biology, Oregon Health; Sciences University, Portland 97201-3098, USA.; CCR5, a receptor for the CC chemokines RANTES, Mip1alpha, and Mip1beta, has been identified as a coreceptor for infections by macrophage-tropic isolates of human immunodeficiency virus type 1 HIV-1). To study its structure and function, we isolated cDNA clones of human, African green monkey (AGM), and NIH/Swiss mouse
Divergent transcriptional regulation among expanding human immunodeficiency virus type 1 subtypes.: J Virol. 1997 Nov;71(11):8657-65. Unique Identifier : AIDSLINE /MED98001388; Montano MA; Novitsky VA; Blackard JT; Cho NL; Katzenstein DA; Essex M; Harvard AIDS Institute, Department of Immunology and Infectious; Diseases, Harvard School of Public Health, Boston, Massachusetts; 02115, USA.; The current AIDS pandemic represents the uneven spread of multiple genetically related subtypes (A to J) of human immunodeficiency virus type 1 (HIV-1). Notably, HIV-1 E in southeast Asia and HIV-1 C in sub-Saharan Africa are expanding faster and are likely of greater global significance than the HIV-1 B subtype preva
Evidence that resolution of rotavirus infection in mice is due to both CD4 and CD8 cell-dependent activities.: J Virol. 1997 Nov;71(11):8735-42. Unique Identifier : AIDSLINE /MED98001397; McNeal MM; Rae MN; Ward RL; Division of Infectious Diseases, Children's Hospital Medical Center,; Cincinnati, Ohio 45229, USA.; The effector functions responsible for resolution of shedding in mice orally inoculated with the murine rotavirus strain EDIM were identified in B-cell-deficient and normal BALB/c mice after monoclonal antibody (MAb) depletion of CD4 and CD8 cells. When depleted of CD8 cells, B-cell-deficient muMt mice resolved their
Evolutionary variants of the human immunodeficiency virus type 1 V3 region characterized by using a heteroduplex tracking assay.: J Virol. 1997 Nov;71(11):8750-8. Unique Identifier : AIDSLINE /MED98001399; Nelson JA; Fiscus SA; Swanstrom R; Lineberger Comprehensive Cancer Center, University of North Carolina; at Chapel Hill, 27599, USA.; Syncytium-inducing (SI) variants of human immunodeficiency virus type 1 (HIV-1) are evolutionary variants that are associated with rapid CD4+ cell loss and rapid disease progression. The heteroduplex tracking assay (HTA) was used to detect evolutionary V3 variants by amplifying the V3 sequences from viral RNA derived
Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.: J Virol. 1997 Nov;71(11):8846-51. Unique Identifier : AIDSLINE /MED98001410; Sharma PL; Crumpacker CS; Division of Infectious Disease, Beth Israel Deaconess Medical Center,; Harvard Medical School, Boston, Massachusetts 02215, USA.; psharma@bidmc.harvard.edu; The Leu-74 to Val (Leu74Val) mutation in human immunodeficiency virus type 1 reverse transcriptase (RT) develops as a consequence of didanosine (ddI) therapy and is associated with a decreased susceptibility to ddI. In this report, we provide evidence that the ddI-associated Leu74Val mutation confers a replication dis
Susceptibility of human immunodeficiency virus type 1 group O isolates to antiretroviral agents: in vitro phenotypic and genotypic analyses.: J Virol. 1997 Nov;71(11):8893-8. Unique Identifier : AIDSLINE /MED98001419; Descamps D; Collin G; Letourneur F; Apetrei C; Damond F; Loussert-Ajaka I; Simon F; Saragosti S; Brun-Vezinet F; Laboratoire de Virologie, Hopital Bichat-Claude Bernard, Paris,; France. diane.descamps@bch-ap-hop-paris.fr; We investigated the phenotypic and genotypic susceptibility of 11 human immunodeficiency virus type 1 (HIV-1) group O strains to nucleoside and nonnucleoside reverse transcriptase (RT) inhibitors and protease inhibitors in vitro. Phenotypic susceptibility was determ
Cross-clade human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte responses in HIV-infected Zambians.: J Virol. 1997 Nov;71(11):8908-11. Unique Identifier : AIDSLINE /MED98001422; Betts MR; Krowka J; Santamaria C; Balsamo K; Gao F; Mulundu G; Luo C; N'Gandu N; Sheppard H; Hahn BH; Allen S; Frelinger JA; Department of Microbiology and Immunology, University of North; Carolina at Chapel Hill, 27599-7290, USA.; We have examined cross-clade HIV-specific cytotoxic T-lymphocyte CTL) activity in peripheral blood of eight Zambian individuals infected with non-B-clade human immunodeficiency virus type 1 HIV-1). Heteroduplex mobility assay and partial sequence analysis of env and gag genes strongly suggests that all the HIV-infecte
Mutational analysis of human T-cell leukemia virus type 2 Tax.: J Virol. 1997 Nov;71(11):8912-7. Unique Identifier : AIDSLINE /MED98001423; Ross TM; Minella AC; Fang ZY; Pettiford SM; Green PL; Department of Microbiology and Immunology, Vanderbilt University; School of Medicine, Nashville, Tennessee 37232-2363, USA.; A mutational analysis of human T-cell leukemia virus type 2 HTLV-2) Tax (Tax-2) was performed to identify regions within Tax-2 important for activation of promoters through the CREB/ATF or NF-kappaB/Rel signaling pathway. Tax-2 mutations within the putative zinc-binding region as well as mutations at the carboxy termi
Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells.: J Virol. 1997 Nov;71(11):8918-22. Unique Identifier : AIDSLINE /MED98001424; Kaneko H; Neoh LP; Takeda N; Akimoto H; Hishikawa T; Hashimoto H; Hirose S; Karaki S; Takiguchi M; Nakauchi H; Kaneko Y; Yamamoto N; Sekigawa I; Department of Internal Medicine and Rheumatology, Juntendo University; School of Medicine, Tokyo, Japan.; We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease
Export of hepatitis B virus RNA on a Rev-like pathway: inhibition by the regenerating liver inhibitory factor IkappaB alpha.: J Virol. 1997 Nov;71(11):8933-9. Unique Identifier : AIDSLINE /MED98001427; Roth J; Dobbelstein M; ZIM, Gastroenterologie, Klinikum der Universitat Marburg, Germany.; Nuclear export of hepatitis B virus (HBV) RNA is mediated by a specific RNA element but, in contrast to lentivirus genomic RNA, does not depend on viral proteins. We show that nonetheless, the export of HBV RNA can be blocked by competitive inhibitors of Rev-mediated lentivirus RNA export, suggesting that the export p
From the Centers for Disease Control and Prevention. Update: trends in AIDS incidence--United States, 1996.: JAMA. 1997 Nov 12;278(18):1485-6. Unique Identifier : AIDSLINE /MED98028587
Involvement of CD8+ RT1.B+ and CD4+ RT1.B+ cells of cervical lymph nodes in the immune response after corneal transplantation in the rat.: Jpn J Ophthalmol. 1997 Jul-Aug;41(4):209-16. Unique Identifier : AIDSLINE /MED97449416; Okada K; Mishima HK; Kawano MM; Mizote H; Minamoto A; Department of Ophthalmology, Hiroshima University School of Medicine,; Japan.; Graft rejection reactions have been observed with concomitant lymphocyte infiltrations after allogenic corneal transplantation, although the cornea is considered to be relatively protected from the systemic immune response. In order to characterize the lymphocytes that accumulate in cervical lymph nodes following tran
Interpersonal psychotherapy: current status.: Keio J Med. 1997 Sep;46(3):105-10. Unique Identifier : AIDSLINE /MED97481020; Weissman MM; Department of Epidemiology in Psychiatry, College of Physicians and; Surgeons, Columbia University, New York, NY, USA.; Weissman@child.cpmc.columbia edu; Interpersonal psychotherapy (IPT), a time-limited treatment for major depression, was developed, defined in a manual, and tested in randomized clinical trials by the late Gerald L Klerman, MD, and collaborators. It has subsequently been modified for different age groups (adolescents-elderly), types of mood disorders (
Correlation of major histocompatibility complex with opportunistic infections in simian immunodeficiency virus-infected rhesus monkeys.: Lab Invest. 1997 Oct;77(4):305-9. Unique Identifier : AIDSLINE /MED98016385; Baskin GB; Bontrop RE; Niphuis H; Noort R; Rice J; Heeney JL; Department of Pathology, Tulane Regional Primate Research Center,; Tulane University, Covington, Louisiana 70433, USA.; The role of the major histocompatibility complex (MHC) in the pathogenesis of AIDS is complex because of compounding variables within the virus, host, and environment. Important variables can be controlled by using the experimental animal model of AIDS induced by simian immunodeficiency virus in rhesus monkeys Macaca
[Direct pharmaceutical costs, diagnostic related groups and CD4 cell count in hospitalized HIV-infected patients]: Med Clin (Barc). 1997 Sep 27;109(10):361-3. Unique Identifier : AIDSLINE /MED98025963; Serrais J; Mallolas J; Ribas J; Servicio de Farmacia, Hospital Clinic i Provincial, Barcelona.; BACKGROUND: To estimate the direct pharmaceutical costs of the HIV-infected patients admitted in the HCP, the variability and the relation between CD4 cell count. PATIENTS AND METHODS: We collected for each patient admitted to Department of infectious Diseases between 1/1/93 to 12/12/94 the direct pharmaceutical cost
[Spinal cord compression in non-Hodgkin's lymphoma. A study of 10 patients]: Med Clin (Barc). 1997 Sep 27;109(10):375-7. Unique Identifier : AIDSLINE /MED98025967; Vela D; Ribera JM; Florensa R; Arellano A; Vaquero M; Batlle M; Flores A; Milla F; Feliu E; Servicio de Hematologia, Hospital Universitario Germans Trias i Pujol,; Universidad Autonoma de Barcelona.; Spinal cord compression is an infrequent event in patients with non-Hodgkin s lymphomas (NHL) and early diagnosis and therapy are required. The main clinical and histologic characteristics as well as the response to therapy in 10 NHL patients with spinal cord compression diagnosed at a single center in a 7-year period
[Lymphomas associated with human immunodeficiency virus infection: a brief biography of an opportunistic tumor]: Med Clin (Barc). 1997 Sep 27;109(10):378-87. Unique Identifier : AIDSLINE /MED98025968; Sanchez Fayos J; Roman Barbero A; Sanchez-Fayos Calabuig P; Servico de Hematologia, Fundacion Jimenez Diaz, Universidad Autonoma; de Madrid.
[Diabetes insipidus and HIV infection (letter)]: Med Clin (Barc). 1997 Sep 27;109(10):396-7. Unique Identifier : AIDSLINE /MED98025971; Reus S; Gil MT; Boix V; Portilla J
[Q fever in patients with HIV infection (letter)]: Med Clin (Barc). 1997 Oct 4;109(11):437-8. Unique Identifier : AIDSLINE /MED98003737; Rivero A; Clavijo E; Santos J; Parra A
[Vertebral osteomyelitis as an atypical presentation of pneumococcal infection in a patient with HIV infection (letter)]: Med Clin (Barc). 1997 Sep 13;109(8):318. Unique Identifier : AIDSLINE /MED97480832; Clavo Sanchez A; Geraldia Lama M; Serrano Gonzalez A; Giron Gonzalez JA
[HIV-negative patients with atypical pulmonary mycobacterium infection. Unfavourable prognosis for M avium infection]: Lakartidningen. 1997 Sep 24;94(39):3398-401. Unique Identifier : AIDSLINE /MED98005783; Heurlin N; Petrini B; Lung- och allergikliniken, HKL-divisionen, Huddinge sjukhus.
Severe hepatitis in patients with AIDS and haemophilia B treated with indinavir [letter; comment]: Lancet. 1997 Aug 2;350(9074):364. Unique Identifier : AIDSLINE /MED97395517; Matsuda J; Gohchi K
Regulation of the response to HIV-1 needs a combined approach [news]: Lancet. 1997 Oct 4;350(9083):1009. Unique Identifier : AIDSLINE /MED97470108; Morris K
Chronic infections and coronary heart disease [letter; comment]: Lancet. 1997 Oct 4;350(9083):1030. Unique Identifier : AIDSLINE /MED97470116; Constans J; Seigneur M; Blann A; Conri C
Combination therapies for HIV infection and genomic drug resistance [comment]: Lancet. 1997 Oct 4;350(9083):970-1. Unique Identifier : AIDSLINE /MED97470089; Katzenstein D; Stanford University Medical Center, CA 94305, USA.
HIV-1 viral load, phenotype, and resistance in a subset of drug-naive participants from the Delta trial. The National Virology Groups. Delta Virology Working Group and Coordinating Committee [see comments]: Lancet. 1997 Oct 4;350(9083):983-90. Unique Identifier : AIDSLINE /MED97470096; Brun-Vezinet F; Boucher C; Loveday C; Descamps D; Fauveau V; Izopet J; Jeffries D; Kaye S; Krzyanowski C; Nunn A; Schuurman R; Seigneurin JM; Tamalet C; Tedder R; Weber J; Weverling GJ; Hopital-Bichat-Claude Bernard, Paris, France.; BACKGROUND: The Delta trial showed that combination therapy zidovudine plus didanosine and zidovudine plus zalcitabine) substantially lengthened life and reduced disease progression compared with zidovudine monotherapy. We did a nested virological study in three countr
HIV-1 in semen: an isolated virus reservoir [letter]: Lancet. 1997 Oct 18;350(9085):1141. Unique Identifier : AIDSLINE /MED98003104; Byrn RA; Zhang D; Eyre R; McGowan K; Kiessling AA
HHV-8 and multiple myeloma in France [letter]: Lancet. 1997 Oct 18;350(9085):1144.