Blood transfusion effects on predominant Th1 or Th2 type helper cell response in cancer surgery (Meeting abstract).

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Blood transfusion effects on predominant Th1 or Th2 type helper cell response in cancer surgery (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 38:A795 1997. Unique Identifier : AIDSLINE ICDB/98637795
Stroehlein MA; Fraunberger P; Stets R; Allgayer H; Tarabichi A; Delanoff C; Gruetzner KU; Wustrow T; Schildberg FW; Heiss MM; Department of Surgery, Klinikum Grosshadern,; Ludwig-Maximilians-University, 81337 Munich, Germany

Abstract: Blood transfusion immunomodulatory effects are reported in many clinical situations. Underlying mechanisms, especially the difference between autologous and allogeneic blood transfusion, are still unclear. Therefore, patients with curative surgery for colorectal cancer were randomized to an autologous blood group (autoG) donating blood preop or to an allogenic blood group (alloG). From 24 patients, blood was taken before blood donation, prior to surgery and at day 3 and 8 postop. Using a fluorescence-cytotoxicity assay, NK and LAK activity were determinated. Blood of 56 patients was drawn preop. and at day 7 postop.; sIL-2R, TNF-alpha, sTNF-alphaR, IL-10 and specific IgG following tetanus-toxoid vaccination were measured by ELISA. After similar decline of NK and LAK activity from surgery to day 3 in both groups (p=0.028/0.012), which doubled to day 8 in alloG,in contrast in autoG recovery from day 3 to 8 in was observed. Both groups postop. showed increase of sIL-2R, TNF-alpha (p=0.01), sTNF-alphaR (p=0.02) and tetanus-IgG. Increase in autoG (deltaTNFalpha=4.9 U/ml) was higher than in alloG (2.0 U/ml), whereas sTNF-alphaR and tetanus-IgG were higher in alloG. sTNF-alphaR acts competitively to TNF-alpha, what might explain the reduced TNF-alpha effect in alloG. Patients of alloG showed postop. Ten-fold increase of IL-10 compared to autoG (p=0.019).These findings indicate immunomodulatory potential of blood donation best explained by the hypothesis of Th1/Th2 shift of pre-Th-cells: Allog. blood transfusion might induce Th2 response, whereas autol transfusion might create Th1 type, which is seen to be more beneficial to patients' course after cancer surgery.

Keywords: *Blood Transfusion Colorectal Neoplasms/*IMMUNOLOGY/*SURGERY Human Killer Cells, Lymphokine-Activated/IMMUNOLOGY Killer Cells, Natural/IMMUNOLOGY Receptors, Interleukin-2/IMMUNOLOGY Receptors, Tumor Necrosis Factor/IMMUNOLOGY Th1 Cells/*IMMUNOLOGY Th2 Cells/*IMMUNOLOGY ABSTRACT
980228
M9820769

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1998. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1998. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .