CD30 expression in activated human peripheral blood lymphocytes (Meeting abstract).

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

CD30 expression in activated human peripheral blood lymphocytes (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 38:A808 1997. Unique Identifier : AIDSLINE ICDB/98637808
Deyev VV; Podack ER; University of Miami School of Medicine, Miami, FL 33101

Abstract: To evaluate CD30 expression in relation to Th1 or Th2 lymphokine profile, PBL from healthy donors were activated with anti-CD3 antibodies in the presence of IL-12 or IL-4 respectively. Significant CD30 expression was observed in unsorted PBL or positively selected CD8+ cells after activation with anti-CD3 and IL-12. These lymphocytes produced a large amount of IFN-gamma, but not IL-5, therefore expressing a Th1 type of lymphokine production. IL-4 together with anti-CD3 in contrast induced PBL to secrete IL-5 but not IFN-gamma, and inhibited or had no effect on CD30 expression. The level of CD30 expression and Th profile induced by IL-12 after primary activation could be downregulated in part by IL-4 during secondary stimulation. Similarly, cells activated with IL-4 that are CD30 low can be induced to express CD30 by IL-12 in secondary activation. Costimulation with anti-CD28 antibodies also upregulated CD30 expression and lymphokine production in anti-CD3 activated lymphocytes.

Keywords: Antibodies/IMMUNOLOGY Antigens, CD30/*METABOLISM Human Interferon Type II/METABOLISM Interleukin-4/PHARMACOLOGY Interleukin-5/METABOLISM *Lymphocyte Transformation Lymphocytes/*IMMUNOLOGY Th1 Cells/IMMUNOLOGY ABSTRACT
980228
M9820767

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