Aberrant Th1 and Th2 cytokine synthesis by normal T cells in Sezary syndrome (Meeting abstract).

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Aberrant Th1 and Th2 cytokine synthesis by normal T cells in Sezary syndrome (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 38:A2323 1997. Unique Identifier : AIDSLINE ICDB/98639323
Lee B-N; Duvic M; Tang C-K; Estrov Z; Reuben JM; University of Texas, M. D. Anderson Cancer Center, Houston, TX; 77030

Abstract: Cutaneous T cell lymphomas (CTCL), lymphoproliferative helper T cell disorders, include mycosis fungoides (MF) and Sezary syndrome (SS). Sezary cells can be distinguished from normal T cells by their inability to express CD7. Others suggested that proliferation of Sezary cells is dependent upon cytokines acting in an autocrine/paracrine manner. MF and SS patients have type 1 (IL-2 and IFN-gamma; Th1) and type 2 (IL-4; Th2) cytokine profiles, respectively and transformation from MF to SS may relate to the conversion from a Th1 to a Th2 cytokine profile. To investigate cytokine synthesis in CTCL, we employed a multi-parameter flow cytometry technique to measure cytoplasmic expression of IL-2, IL-4, and IFN-gamma in mitogen-activated normal T and Sezary cells in the peripheral blood (PB) of CTCL patients compared to normal T cells of MF and control subjects. There were no differences in the ability of normal T cells from control and MF donors to synthesize these cytokines. Although the % of Sezary cells of SS patients synthesizing IL-2 was similar to normal T cells of MF and control subjects, the % of normal T cells of SS was significantly lower (p less than 0.05) in their expression of IL-2. On the other hand, the % of Sezary cells from SS donors synthesizing IFN-gamma and IL-4 was significantly lower than normal T cells of both MF and control subjects. These data indicate that in addition to an apparent defect in the synthesis of IFN-gamma and IL-4 by Sezary cells, the normal T cell compartment of SS patients is also defective with respect to cytokine synthesis.

Keywords: Cytokines/*IMMUNOLOGY/*METABOLISM Human Interferon Type II/METABOLISM Interleukins/METABOLISM Lymphoma, T-Cell, Cutaneous/*IMMUNOLOGY/*METABOLISM Mycosis Fungoides/*IMMUNOLOGY/*METABOLISM Sezary Syndrome/*IMMUNOLOGY/*METABOLISM T-Lymphocytes/*METABOLISM *Th1 Cells *Th2 Cells ABSTRACT
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