Role of surgery in multi-drug-resistant tuberculosis: results of 27 cases.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Role of surgery in multi-drug-resistant tuberculosis: results of 27 cases.

Eur J Cardiothorac Surg. 1997 Oct;12(4):531-4. Unique Identifier : AIDSLINE MED/98036161
Kir A; Tahaoglu K; Okur E; Hatipoglu T; Sureyyapasa Center for Chest Diseases and Thoracic Surgery,; Istanbul, Turkey.

Abstract: OBJECTIVE: To evaluate the results of resectional surgery as an adjuvant therapy in multi-drug resistant tuberculosis. METHODS: A total of 27 human immunodeficiency virus (HIV)-negative patients with multi-drug resistant tuberculosis underwent resectional surgery between 1993 and 1996. The lesions were bilateral in 16 cases, with a preponderance of cavities on one side. Out of 27 cases, 5 patients had unilaterally destroyed lung; 20 patients underwent pneumonectomy (15 left, 5 right). Lobectomy operations included bilobectomy superior (n = 1), right lower lobectomy (n = 2), right upper lobectomy (n = 3), and left upper lobectomy with superior segmentectomy (n = 1). RESULTS: Because of haemorrhage, 2 cases who underwent a right and left pneumonectomy, respectively, required revision on the first day . Bronchopleural fistula was found in 2 cases with left pneumonectomy. Apical residual space was left in one of the 3 patients who underwent right upper lobectomy. Retreatment protocols resulted in negative cultures and smears in all patients with an average duration of 4 months (1-6 months). A total of 4 patients (16%) completed a retreatment period of 18-24 months with negative cultures. Only 1 patient (3.7%) developed relapse in the 17th month of retreatment. Patients with negative cultures numbered 22 and continued receiving retreatment. CONCLUSIONS: Our results indicate that surgical management of multi-drug resistant tuberculosis, combined with chemotherapy, provides a more favourable outcome than that obtained with medical therapy alone.

Keywords: Adult Antitubercular Agents/THERAPEUTIC USE AIDS-Related Opportunistic Infections/DRUG THERAPY/*SURGERY Combined Modality Therapy Drug Therapy, Combination Female Human Male Pneumonectomy/METHODS Treatment Outcome Tuberculosis, Multidrug-Resistant/DRUG THERAPY/*SURGERY Tuberculosis, Pulmonary/DRUG THERAPY/*SURGERY JOURNAL ARTICLE
980228
M9820733

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