IgA immunity in HIV type 1-infected chimpanzees. II. Mucosal immunity.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

IgA immunity in HIV type 1-infected chimpanzees. II. Mucosal immunity.

AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1273-82. Unique Identifier : AIDSLINE MED/97479763
Black KP; Fultz PN; Girard M; Jackson S; Department of Microbiology, University of Alabama at Birmingham,; 35294-2170, USA.

Abstract: Vaginal wash fluids from chimpanzees cervically infected with HIV-1 and saliva from intravenously and cervically infected chimpanzees were analyzed for total IgA, IgA1, IgA2, IgG, and albumin concentrations and for reactivity against HIV-1. No overt abnormalities were detected in salivary immunoglobulin or albumin concentrations in either group of animals. Anti-HIV IgA and IgA subclass antibodies were demonstrated in saliva from five of six intravenously infected chimpanzees and in two of four cervically infected animals, with titers ranging from 1:5 to 1:20. HIV-specific IgG antibodies could be detected in saliva from half of the systemically infected group, the highest titer being 1:2560, whereas the highest anti-HIV IgG titer in the mucosally infected group was 1:20. Western blot analyses of the first saliva samples obtained after initial virus exposure revealed IgG, IgA, and IgA subclass antibodies directed at the env, gag, or pol gene products in both groups of chimpanzees. Examination of IgG, IgA, IgA1, and IgA2 concentrations in vaginal washes from cervically infected animals showed that IgG levels were highest, but IgA and IgA subclass reactivities against HIV-1 were more prominent than that of IgG. These results demonstrate that systemic infection of chimpanzees with HIV-1 elicits mucosal responses specific for HIV, and vaginal infection of chimpanzees induces a common mucosal immune response reminiscent of that in humans.

Keywords: Albumins/ANALYSIS Animal Blotting, Western Cervix Uteri/VIROLOGY Enzyme-Linked Immunosorbent Assay Female Gene Products, env/IMMUNOLOGY Gene Products, pol/IMMUNOLOGY HIV Antibodies/*ANALYSIS/IMMUNOLOGY HIV Antigens/IMMUNOLOGY HIV Core Protein p24/IMMUNOLOGY HIV Infections/*IMMUNOLOGY HIV-1/*IMMUNOLOGY IgA/ANALYSIS/*IMMUNOLOGY IgG/ANALYSIS/IMMUNOLOGY *Immunity, Mucosal Male Pan troglodytes Saliva/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Vagina/IMMUNOLOGY JOURNAL ARTICLE
980228
M9820726

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