Human salivary histatin-5 exerts potent fungicidal activity against Cryptococcus neoformans. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Human salivary histatin-5 exerts potent fungicidal activity against Cryptococcus neoformans.

Biochim Biophys Acta. 1997 Oct 20;1336(3):367-9. Unique Identifier : AIDSLINE MED/98032985
Tsai H; Bobek LA; Department of Oral Biology, School of Dental Medicine, State; University of New York at Buffalo, 14214, USA.

Abstract: Human salivary histatins (Hsns) have been known to be potent antifungal agents against Candida albicans for more than a decade. Here, we report that Hsns are also effective in killing another medically important opportunistic fungal pathogen, Cryptococcus neoformans, which has become a new threat among the immunocompromised patients, especially AIDS patients. In fact, the cidal activity of Hsn-5 against C. neoformans is as high as that against C. albicans.
Keywords: Amino Acid Sequence Antifungal Agents/*PHARMACOLOGY Candida albicans/DRUG EFFECTS Chromatography, High Pressure Liquid Cryptococcus neoformans/*DRUG EFFECTS Human Microbial Sensitivity Tests Molecular Sequence Data Recombinant Proteins/BIOSYNTHESIS/CHEMISTRY/PHARMACOLOGY Saccharomyces cerevisiae/DRUG EFFECTS *Saliva Salivary Proteins/BIOSYNTHESIS/CHEMISTRY/*PHARMACOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDaminoacidsequenceantifungalagents/KWDpharmacologycandidaalbicans/drugeffectschromatography,highpressureliquidcryptococcusneoformans/KWDdrugeffectshumanmicrobialsensitivitytestsmolecularsequencedatarecombinantproteins/biosynthesis/chemistry/pharmacologysaccharomycescerevisiae/drugeffectsKWDsalivasalivaryproteins/biosynthesis/chemistry/KWDpharmacologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
980228
M9820699

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