1998

AIDS in the deaf community, deaf in the AIDS community : creating partnerships. [videorecording]: San Francisco : The Center, 1996 1 videocassette (35 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9717224
Politicas publicas e saude relacionadas a AIDS : seminario : anais.: Rio de Janeiro : IMS/UERJ, 1995 52 p Unique Identifier : AIDSLINE CAT/9703512; Parker RG
Report on the Kenya national KABP survey on AIDS, 1990-1991.: Nairobi, Kenya : Initiatives Publishers, 1995 xv, 92 p. : ill Unique Identifier : AIDSLINE CAT/9712506; Onyango P
La double rencontre : toxicomanie & SIDA.: Ramonville Saint-Agne : Eres, c1996 352 p Unique Identifier : AIDSLINE CAT/9702386; Rouchy JC
AIDS und HIV in der Schweiz : epidemiologische Situation Ende 1995.: Bern : Bundesamt fur Gesundheit, Abt. Epidemiologie und Infektionskrankheiten, Sektion Virale Krankheiten, [1996] 52 p. : ill Unique Identifier : AIDSLINE CAT/9710826; Gebhardt M
Alternativ-Medizin bei AIDS.: Hamburg : Verlag Dr. Kovac, c1997 230 p. : ill Unique Identifier : AIDSLINE CAT/9710340; Zur Lippe C
Aktual'nye problemy VICh-infektsii v Sibiri : sbornik nauchno-prakticheskikh rabot territorial'nykh tsentrov po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami.: Barnaul : Izd-vo Altaiskogo gosuniversiteta, [1995?]- v. : ill Unique Identifier : AIDSLINE CAT/9705522; Obert AS
AIDS, allergy, and rheumatology.: Totowa, NJ : Humana Press, c1997 vii, 102 p (Allergy and immunology ; 3) Unique Identifier : AIDSLINE CAT/9716729; Lane NE
Emerging viruses : AIDS and Ebola : nature, accident, or intentional. Reference ed.: Rockport, MA : Tetrahedron, 1997 xxvi, 563 p. : ill Unique Identifier : AIDSLINE CAT/9712772; Horowitz LG
Questions & answers on AIDS. 3rd ed.: Los Angeles, Calif. : Health Information Press, c1997 xxii, 292 p. : ill Unique Identifier : AIDSLINE CAT/9714910; Frumkin LR; Leonard JM
UNICEF response to AIDS in Uganda : expanded communications programme, 1991-1995 : draft plan of operations.: [Kampala : UNICEF, 1991] ii, 53 leaves Unique Identifier : AIDSLINE CAT/9711345
AIDS : zagrozenia spoleczne : aspekty medyczne, pedagogiczne, kulturowe.: Olsztyn : Wyzsza Szkola Pedagogiczna w Olsztynie, 1993 143 p Unique Identifier : AIDSLINE CAT/9610339; Czaplicki Z
Dangerous inhibitions : how America is letting AIDS become an epidemic of the young.: [Cambridge, Mass.?] : Harvard AIDS Institute, [1997] 43 p. : ill (Monograph series. Occasional paper ; #3) Unique Identifier : AIDSLINE CAT/9713458; Collins C
HIV in Canada : surveillance report for the period 1985-1995.: [Ottawa, Ont.] : National HIV Database Project, Division of HIV/AIDS Surveillance, Bureau of HIV/AIDS and STD, Laboratory Centre for Disease Control, Health Protection Branch, Health Canada, c1997 vi, 16 p. : ill Unique Identifier : AIDSLINE CAT/9713449
Wisconsin comprehensive HIV prevention plan. 1995-: Madison, WI : Wisconsin AIDS/HIV Program, 1994- v. : ill Unique Identifier : AIDSLINE CAT/9617135
Evaluation systemischer Psychotherapie bei der Behandlung psychosomatischer Patienten : Moglichkeiten systemtherapeutischer Interventionen am Beispiel HIV-Infizierter und AIDS erkrankter Patienten.: Munster : Lit Verlag, [1997] vii, 459 p. : ill (Fortschritte der Psychologie ; Bd. 20) Unique Identifier : AIDSLINE CAT/9707687; Vogt-Hillmann M
Nutritional aspects of HIV infection.: New York : Chapman & Hall, 1998 Unique Identifier : AIDSLINE CAT/9800723; Miller TL; Gorbach SL
Wasting und AIDS : die Behandlung der HIV-bedingten Kachexie.: Stuttgart ; New York : Thieme, 1997 viii, 138 p. : ill (HIV-Medizin--Standards of care) Unique Identifier : AIDSLINE CAT/9710862; Jager H
Interim recommendations for deferral of donors at increased risk for HIV-1 Group O infection; guidance document; availability--FDA. Notice.: Fed Regist. 1997 Sep 23;62(184):49695. Unique Identifier : AIDSLINE AHA/98055401; The Food and Drug Administration ( FDA ) is announcing the availability of a guidance document entitled Interim Recommendations for Deferral of Donors at Increased Risk for HIV-1 Group O Infection, dated December 11, 1996. The guidance document, which discusses the appearance in 1996
FASA (Federal Acquisition Streamlining Act of 1994) impact still debated as price list stays on hold.: Hosp Mater Manage. 1997 Sep;22(9):1, 12-3. Unique Identifier : AIDSLINE AHA/98038692; DeJohn P
Controversial issues surrounding the case of HIV infections and AIDS through the use of unheated commercial blood products.: Jpn Hosp. 1997 Jul;16:1-3. Unique Identifier : AIDSLINE AHA/98045577; Morohashi Y; Japan Hospital Association.; It has been reported in the recent years that not a small number of Japanese patients, including 1,792 hemophiliacs, have contracted HIV infections through the use of commercially available unheated blood products, such as factor VIII or IX concentrates. Many of them subsequently developed AIDS, and died shortly there
International forum: Saudi Arabia. Donor screening for HTLV-I in Saudi Arabia: is it cost effective?: Transfus Sci. 1997 Mar;18(1):45-7. Unique Identifier : AIDSLINE HTA/98037880; Bernvil SS; Andrews V; Coulter N; Dept of Pathology and Laboratory Medicine, King Faisal Spec.; Hospital and Research Centre, Riyadh, Saudi Arabia.; After screening over 100,000 blood donations for the presence of anti-HTLV-I antibodies, a final prevalence of 0.0038% was established in a multinational donor population. Among 38,201 donations by Saudi Arabian donors, the prevalence was found to be 0.0052%. Fifty-eight donors were found to be repeat reactive in the
Reliability of a new recombinant immunoblot assay (RIBA HIV-1/HIV-2 SIA) as a supplemental (confirmatory) test for HIV-1 and HIV-2 infections.: Transfus Sci. 1997 Mar;18(1):63-9. Unique Identifier : AIDSLINE HTA/98037883; Mas A; Soriano V; Gutierrez M; Fumanal F; Alonso A; Gonzalez-Lahoz J; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.; The diagnosis of HIV infection is usually determined using serological methods. Positive results in a screening test should be confirmed with more specific supplementary assays, and the Western blot (WB) is the most frequently used. However, problems of WB, particularly in regard to the significance of indeterminate r
Immunotherapy with tumor vaccines in renal cancer (Meeting abstract).: Ann Oncol; 7(Suppl 1):18 1996. Unique Identifier : AIDSLINE ICDB/98625860; Pardoll DM; John Hopkins University School of Medicine, Baltimore, MD; There is mounting evidence that many if not all tumors possess antigens capable of being recognized by T cells. Over the past few years, our group has been analyzing the immune response induced by immunization with tumors engineered to secrete cytokines locally. In a study comparing multiple different cytokine genes,
Blood transfusion effects on predominant Th1 or Th2 type helper cell response in cancer surgery (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A795 1997. Unique Identifier : AIDSLINE ICDB/98637795; Stroehlein MA; Fraunberger P; Stets R; Allgayer H; Tarabichi A; Delanoff C; Gruetzner KU; Wustrow T; Schildberg FW; Heiss MM; Department of Surgery, Klinikum Grosshadern,; Ludwig-Maximilians-University, 81337 Munich, Germany; Blood transfusion immunomodulatory effects are reported in many clinical situations. Underlying mechanisms, especially the difference between autologous and allogeneic blood transfusion, are still unclear. Therefore, patients with curative surgery for colorectal cancer were randomized to an autologous blood group (aut
Phenotypic analysis of human lymphocyte sub-populations post treatment with pi-water (MRN-100) (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A801 1997. Unique Identifier : AIDSLINE ICDB/98637801; Ghoneum M; Namatalla G; Kijima Y; Drew University of Med. and Sc., 1621 E 120 Street, Los Angeles,; CA; We have recently demonstrated that pi-water (MRN-100) is a potent biological response modifier (BRM) that enhances Natural Killer (NK) cell activity in vivo. The MRN-100 is an iron base compound derived from bivalent and trivalent ferrates. In this study a phenotypic analysis of human lymphocyte sub-populations post t
CD30 expression in activated human peripheral blood lymphocytes (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A808 1997. Unique Identifier : AIDSLINE ICDB/98637808; Deyev VV; Podack ER; University of Miami School of Medicine, Miami, FL 33101; To evaluate CD30 expression in relation to Th1 or Th2 lymphokine profile, PBL from healthy donors were activated with anti-CD3 antibodies in the presence of IL-12 or IL-4 respectively. Significant CD30 expression was observed in unsorted PBL or positively selected CD8+ cells after activation with anti-CD3 and IL-12. T
CD-8 T-cells suppress tumorigenicity of E1A transfected murine fibrosarcoma cells (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A811 1997. Unique Identifier : AIDSLINE ICDB/98637811; Sugg SL; Lange J; Fraker DL; Department of Surgery, University of Toronto, Ontario, Canada; Introduction: The early region 1A (E1A) of adenovirus type 2 and 5 (Ad 2,5) was recently found to have tumor suppressive functions. We investigated the hypothesis that suppressed tumorigenicity of E1A transfected murine fibrosarcoma cells is immunologically mediated. Methods: Murine fibrosarcoma cell line 102.4 was tr
Mouse mammary tumor virus (MMTV) antigens expressed in nuclei of variant lymphoma cells (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A1058 1997. Unique Identifier : AIDSLINE ICDB/98638058; Hoch-Marchaim H; Hasson T; Rorman E; Braun E; Hochman J; Hebrew University of Jerusalem, Jerusalem, Israel, 91904; Previous studies demonstrated that retroviral proteins (including Tat, Rev and Rex) are localized to the nucleus. To our knowledge, nuclear localization of proteins translated from env or LTR regions of the Mouse Mammary Tumor Virus (MMTV) has not been reported. Monoclonal antibodies (MAbs) were raised against non-tum
Cellular host range of human herpesvirus 8 (HHV8) (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A1061 1997. Unique Identifier : AIDSLINE ICDB/98638061; Blackbourn D; Lennette E; Witte M; Way D; Klencke B; Levy J; University of California, San Francisco, CA 94143; Objective: To determine the in vitro tropism of HHV8. Methods: Over 40 cells and cell lines were evaluated for their susceptibility to HHV8 infection, including B cells, T cells, epithelial cells and endothelial cells (EC). Infection studies were performed by inoculation with cell-free HHV8. This virus was prepared fr
Status of p53 and WAF1/CIP1 in anogenital lesions harboring human papillomavirus and human immunodeficiency virus (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A1063 1997. Unique Identifier : AIDSLINE ICDB/98638063; Arany I; Yen A; Tyring SK; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston, TX; Human papillomaviruses (HPVs) express various gene products, such as E6 protein which complexes with the p53 tumor suppressor protein and therefore diminishes p53-related regulatory mechanisms. Furthermore, HIV infection is believed to activate latent HPV infection and transcription. Accordingly, we carried out experi
Epstein-Barr virus-induced long-term proliferation of CD4-positive lymphocytes leading to T lymphoblastoid cell lines carrying latent Epstein-Barr virus (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A1066 1997. Unique Identifier : AIDSLINE ICDB/98638066; Guan MX; Henderson EE; Department of Microbiology and Immunology, and the Fels Institute; for Cancer Research and Molecular Biology, Temple University; School of Medicine, Philadelphia, PA 19140; The recent emergence of acquired immunodeficiency syndrome (AIDS)-related, Epstein-Barr virus (EBV)-associated T cell lymphomas as a new pathoclinical entity, conclusively demonstrates that EBV infection of T cells occurs in vivo. Whether the sequence of events leading to the emergence of EBV-carrying T cell lymphomas
Molecular analysis of human T cell leukemogenesis by HTLV-1 Tax protein (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A1075 1997. Unique Identifier : AIDSLINE ICDB/98638075; Petropoulos L; Crepieux P; Lin R; Hiscott J; Molecular Oncology, Lady Davis Inst., McGill University,; Montreal, Canada H3T 1E2; Human T cell Leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia (ATL). The oncogenic potential of HTLV-1 resides in the 40 kD viral Tax protein which has been characterized as a strong transactivator of transcription. One of the targets of interaction for the Tax protein is NF-kappaB/Rel,
Improved gene transfer into human cancer cell lines using retrovirus with the gibbon ape leukemia virus envelope and a cationic liposome (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A1188 1997. Unique Identifier : AIDSLINE ICDB/98638188; Kim Y-S; Lim HK; Min JS; Institute for Cancer Research, College of Medicine, Yonsei; University, Seoul 120-752, Korea; Efficient in vivo gene transfer is an important goal for cancer gene therapy. Although adenoviral vectors have proven effective for this purpose in animal models, the ability to achieve comparable gene transfer with retroviral vectors would provide potentially desirable safety and toxicity features for clinical studie
Decreased levels of S-adenosylmethionine (SAM) and hypomethylation of the H-ras gene in transformed pancreatic acinar cells from ddI-treated rats (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A1198 1997. Unique Identifier : AIDSLINE ICDB/98638198; Lyn-Cook BD; Wise C; Green B; Johnson J; Jin B; Sandberg JA; Patterson TA; Slikker W; Divisions of Molecular Epidemiology and Neurotoxicology,; FDA/NCTR, Jefferson, Arkansas 72079; Acute pancreatitis is often detected in AIDS patients given dideoxyinosine (ddI, Videx ), a nucleoside analog. This study was undertaken to determine the molecular effects on normal pancreatic acinar cells in vivo and in vitro from controls and ddI-tre
Selection and characterization of AZT-resistant mutants of DNA Polymerase beta (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A1216 1997. Unique Identifier : AIDSLINE ICDB/98638216; Kosa JL; Sweasy JB; Yale Medical School, New Haven, CT 06520; DNA polymerase beta (Pol beta) is implicated in DNA repair synthesis, a role consistent with its in vitro aptitude for filling short gaps in DNA. Pol beta is inhibited in vitro by the nucleoside analog AZT , which Pol beta incorporates into DNA, result
Human immunodeficiency virus type 1 Tat protein up-regulates interleukin-13 receptor expression on renal cell carcinoma (RCC) cells (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A2038 1997. Unique Identifier : AIDSLINE ICDB/98639038; Husain S; Puri R; Laboratory of Molecular Tumor Biology, Division of Cellular and; Gene Therapies, CBER, FDA, Bethesda, MD 20892; The HIV-1 regulatory gene, tat, encodes an early transactivator protein (Tat) necessary for virus replication. This Tat protein is actively secreted by infected cells. We have recently demonstrated that constitutive expression of the tat gene in a Burkitt lymphoma cell line up-regulates interleukin-4 receptors (IL-4R)
Anti 4-1BB monoclonal antibodies activate T-cells and eradicate established tumors (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A2320 1997. Unique Identifier : AIDSLINE ICDB/98639320; Melero I; Shuford WS; Ashe Newby S; Aruffo A; Ledbetter JA; Hellstrom KE; Mittler RS; and Chen L; Bristol-Myers Squibb Pharmaceutical Research Institute, 3005; First Avenue, Seattle, WA 98121; The 4-1BB glycoprotein is a member of the tumor necrosis factor receptor superfamily and binds to a high affinity ligand expressed on several antigen-presenting cells such as macrophages and activated B-cells. Expression of 4-1BB is restricted to primed CD4+ and CD8+ T-cells and signaling either by binding to its natu
Aberrant Th1 and Th2 cytokine synthesis by normal T cells in Sezary syndrome (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A2323 1997. Unique Identifier : AIDSLINE ICDB/98639323; Lee B-N; Duvic M; Tang C-K; Estrov Z; Reuben JM; University of Texas, M. D. Anderson Cancer Center, Houston, TX; 77030; Cutaneous T cell lymphomas (CTCL), lymphoproliferative helper T cell disorders, include mycosis fungoides (MF) and Sezary syndrome (SS). Sezary cells can be distinguished from normal T cells by their inability to express CD7. Others suggested that proliferation of Sezary cells is dependent upon cytokines acting in an
Mechanisms underlying the thymic involution induced by a murine mammary adenocarcinoma (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A2326 1997. Unique Identifier : AIDSLINE ICDB/98639326; Sun Q; Adkins B; Lobo D; Zacharievich N; Charyulu V; Lopez DM; Department of Microbiology and Immunology, University of Miami; School of Medicine, Miami, FL 33136; A profound thymic atrophy has been observed in mice bearing large adenocarcinomas of the mammary gland. Although there is no decrease in the overall percentages of Thy-1+ cells in tumor bearers, the majority of the remaining cells are of a Thy-1 low phenotype. There was a dramatic decrease in the percentage of double
Transplacental incorporation of 3'-azido-2',3'-dideoxythymidine(AZT) into DNA of fetal CD-1 mice and Erythrocebus patas monkeys (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A2372 1997. Unique Identifier : AIDSLINE ICDB/98639372; Olivero OA; Anderson LM; Diwan BA; Rice JM; Yuspa SH; Laing CP; Chang PK; Jones AB; Poirier MC; LCCTP,NCI,NIH, Bethesda, MD 20892; AZT administration to reduce fetal transmission of HIV in human pregnancy is highly effective and currently in widespread clinical use. In order to explore possible toxic effects to the fetus, AZT incorporation was investigated in fetal DNA of monkeys
Interleukin 18 (interferon gamma-inducing factor) exhibits antitumor effects in mice challenged intraperitoneally with syngeneic Meth A sarcoma (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A2388 1997. Unique Identifier : AIDSLINE ICDB/98639388; Micallef MJ; Hanaya T; Kohno K; Arai S; Tanimoto T; Ikeda M; Kurimoto M; Fujisaki Institute, Hayashibara Biochemical Labs., Okayama 702,; Japan; Interleukin 18 (IL-18, previously interferon gamma-inducing factor) is an 18.2 kD molecule produced by macrophages and related cells which reportedly enhances natural killer (NK) cell activity and T helper (Th) type 1 cytokine production in murine and human immunocompetent cell cultures. We here report that IL-18 exhi
Antibodies to IP-10 and MIG block IL-12-mediated T-cell infiltration and RENCA tumor regression (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A2394 1997. Unique Identifier : AIDSLINE ICDB/98639394; Tannenbaum C; Tubbs R; Finke J; Bukowsi R; Hamilton T; The Cleveland Clinic Foundation, Cleveland, OH 44195; RENCA tumor tissue from IL-12 treated mice express mRNAs encoding the chemokine molecules IP-10 and MIG, are heavily infiltrated with CD8+ T cells, and express the cytolytic molecules perforin and granzyme B. Mice bearing RENCA tumors were treated with IL-12 in the presence or absence of intraperitoneally-administered
Tumor-induced IL10 production in vivo suppresses the development of delayed type hypersensitivity (DTH) to tumor associated antigens (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 38:A2397 1997. Unique Identifier : AIDSLINE ICDB/98639397; Maguire HC Jr; Ketcha KA; Halak BK; Holmes KL; Lattime EC; Thomas Jefferson University, Philadelphia, PA 19107; IL10 inhibits the induction of cell-mediated immunity (CMI) by suppressing antigen presentation to TH1 cells. We have published that biopsy specimens from patients with melanoma and bladder carcinoma express IL10 mRNA and secrete IL10 protein. To assess the role of IL10 in the development of CMI to tumor antigens, we
Cytokine production in response to human papillomavirus (HPV) 16 E6 and E7 peptides in patients (pts) with low-grade squamous intra-epithelial lesions (SIL) and correlation with follow-up cervical cytology (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A1293 1997. Unique Identifier : AIDSLINE ICDB/98643293; Timmins P; Wang Y; Fan Z; Ho G; Fields A; Goldberg G; Runowicz C; Qu W; Kadish A; Albert Einstein College of Medicine, Bronx, NY; Our laboratory has previously demonstrated that the presence of T cell lymphoproliferative (LP) responses to peptides from the E6 and E7 oncogenic proteins of HPV 16 correlated with resolution of HPV Infection, regression of squamous intraepithelial lesions (SIL), and with resolution of SIL by cervical cytology. These
A polyvalent melanoma vaccine induces MAGE-3 and MART-1/Melan-A specific CD8+ T cell responses that correlate with clinical outcome (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A1548 1997. Unique Identifier : AIDSLINE ICDB/98643548; Oratz R; Reynolds SR; Shapiro RL; Harris M; Roses D; Vukmanovic S; Bystryn JC; Depts. of Medicine, Dermatology, Surgery and Pathology, Kaplan; Cancer Center, NYU Medical Center, NY, NY 10016; A critical requirement to use tumor antigens as vaccines is that they stimulate CD8+ T cell responses. In this study, we tested the ability of a shed, polyvalent, melanoma antigen vaccine to induce such responses to the melanoma-associated antigens, MAGE-3 and MART-1/Melan-A. Fifteen HLA-A2+ patients with resected mal
Gene therapy with recombinant adenovirus (rAd) in humans: virological follow-up of patients and medical staff included in the French phase I study (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A1555 1997. Unique Identifier : AIDSLINE ICDB/98643555; Gautier E; Saulnier P; Farace F; LeCesne A; Opolon P; Zitvogel L; Escudier B; Schatz C; Courtney M; LeChevalier T; Tancrede C; Tursz T; Roussy IG; Villejuif and Laboratoire Transgene, Strasbourg, France; In our gene therapy program evaluating the local delivery of therapeutic genes by rAd, 10 patients (pts) (3 at 10(7) and 10(8), 4 at 10(9) pfu) have now been included in the phase I study of intratumoral administration of a rAd-betaGAL in lung cancer. One of the main objectives was to evaluate the safety of rAd-betaGA
The generation of CD4+ and CD8+ T cell responses from patients vaccinated with mutant Ras peptides corresponding to the patient's own Ras mutation (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 16:A1566 1997. Unique Identifier : AIDSLINE ICDB/98643566; Khleif SN; Abrams S; Allegra C; Bastian A; Bergmann E; Bernstein S; Chen A; Chung Y; Hamilton JM; Kohler DR; Morrison G; Schlom J; National Cancer Institute, Bethesda, MD; Cancers in humans are commonly associated with mutations in the Ras genes. These genes produce mutated proteins that are unique to cancer cells; codon 12 mutations form more than 90% of all ras mutations. To determine if peptides reflecting point mutations in Ras oncogenes are immunogenic in human, we conducted a phas
Legal history of emergency medicine from medieval common law to the AIDS epidemic.: Am J Emerg Med. 1997 Nov;15(7):658-70. Unique Identifier : AIDSLINE MED/98043184; Curran WJ; Department of Health Policy and Management, School of Public; Health, Harvard University, Boston, MA, USA.; The early development of legal obligation in emergency medicine is traced through medieval English common law to the first stages of American law after Independence. An identifiable set of legal principles in the nineteenth and early twentieth centuries is described. The movement away from an absence of legal and ethi
Etiology of pediatric ischemic stroke.: Am J Emerg Med. 1997 Nov;15(7):671-9. Unique Identifier : AIDSLINE MED/98043185; Ferrera PC; Curran CB; Swanson H; Department of Emergency Medicine, Albany Medical Center, NY; 12208, USA.
International clinical trials of HIV vaccines: II. phase I trial of an HIV-1 synthetic peptide vaccine evaluating an accelerated immunization schedule in Yunnan, China.: Asian Pac J Allergy Immunol. 1997 Jun;15(2):105-13. Unique Identifier : AIDSLINE MED/98004261; Li D; Forrest BD; Li Z; Xue P; Hanson CV; Duan S; Cheng H; Li M; Wang CY; Koff WC; Ministry of Public Health, Temple of Heaven, Beijing, China.; A Phase 1, double-blind, placebo controlled trial was conducted in Longchuan County, China , to evaluate the safety and immunogenicity of a prototype HIV-1 synthetic peptide vaccine in a target population at risk for HIV infection, and to establish the infrastructure for future large
Immune status in congenital infections by TORCH agents in pregnant Thais.: Asian Pac J Allergy Immunol. 1997 Jun;15(2):93-7. Unique Identifier : AIDSLINE MED/98004259; Taechowisan T; Sutthent R; Louisirirotchanakul S; Puthavathana P; Wasi C; Department of Biology, Faculty of Science, Silpakorn University,; Nakorn Pathom, Thailand.; A cross-sectional, sero-epidemiological survey of the prevalence of antibodies to TORCH agents during various stages of gestation revealed an overall rate of 13-15 percent having antibodies to Toxoplasma gondii; 85-87 percent, to rubella ; 79-81 percent, to herpes simplex virus (HSV); 100 percent, to
[Treatment compliance is the key word in combination therapy. Current image of AIDS (2)]: TVZ. 1997 Sep 20;107(17):498-502. Unique Identifier : AIDSLINE MED/98060333; Tesselaar J; van der Kruk T; Academisch Medisch Centrum te Amsterdam.
[Moving forward in AIDS care. 9th annual ANAC Conference in Chicago (Association of Nurses in AIDS Care)]: TVZ. 1997 Feb 15;107(4):105. Unique Identifier : AIDSLINE MED/98054829; Hoeksema K
Nucleic-acid immobilization, recognition and detection at chronopotentiometric DNA chips.: Biosens Bioelectron. 1997;12(7):587-99. Unique Identifier : AIDSLINE MED/98032722; Wang J; Cai X; Rivas G; Shiraishi H; Dontha N; Department of Chemistry and Biochemistry, New Mexico State; University, Las Cruces 88003, USA.; Wide-scale DNA testing requires the development of fast, small, easy-to-use biosensing devices. Various synthetic oligonucleotides and DNA have thus been immobilized onto microfabricated thick-film carbon transducers for performing several new nucleic-acid assay protocols. These include hybridization detection of nucl
Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice.: APMIS. 1997 Nov;105(11):838-42. Unique Identifier : AIDSLINE MED/98055272; Moser C; Johansen HK; Song Z; Hougen HP; Rygaard J; Hoiby N; Department of Clinical Microbiology, Rigshospitalet, Copenhagen,; Denmark.; The chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) is characterized by a pronounced antibody response and microcolonies surrounded by numerous polymorphonuclear neutrophils (PMN). Poor prognosis is correlated with a high antibody response to P. aeruginosa antigens. An animal model of this infect
Mechanism of inactivation of enveloped viruses by the biosurfactant surfactin from Bacillus subtilis.: Biologicals. 1997 Sep;25(3):289-97. Unique Identifier : AIDSLINE MED/97467281; Vollenbroich D; Ozel M; Vater J; Kamp RM; Pauli G; Max-Volmer-Institut fur Biophysikalische Chemie und Biochemie,; Fachgebiet Biochemie und Molekulare Biolopgie, Technische; Universitat Berlin, Franklinstrasse 29, 10587 Berlin, Germany.; The antiviral activity of surfactin, a cyclic lipopeptide antibiotic and biosurfactant produced by Bacillus subtilis, was determined for a broad spectrum of different viruses, Semliki Forest virus (SFV), herpes simplex virus (HSV-1, HSV-2), suid herpes virus (SHV-1), vesicular stomatitis virus (VSV), simian immunodefi
Knowledge of HIV/AIDS modes of transmission and means of protection in different European countries.: Ann Ig. 1997 Jul-Aug;9(4):265-72. Unique Identifier : AIDSLINE MED/98024657; Marquet J; Zantedeschi E; Huynen P; Centre d'Etudes Sociologiques, Facultes Universitaires; Saint-Louis, Bruxelles.; This study was undertaken to assess the state of the european population s knowledge on HIV transmission and means of protection. Data were delivered from different national surveys based on questionnaires administered to general population samples. The results showed that the population s knowledge on HIV/AIDS are in
HIV disease and anesthesiologists' risk: can old dogs learn new tricks? [editorial; comment]: J Clin Anesth. 1997 Nov;9(7):525-6. Unique Identifier : AIDSLINE MED/98006975; Layon AJ
Compliance with gloving in anesthesia: an observational study of gloving practice at induction of general anesthesia [see comments]: J Clin Anesth. 1997 Nov;9(7):527-31. Unique Identifier : AIDSLINE MED/98006976; Ben-David B; Gaitini L; Department of Anesthesia, B'nai Zion Medical Center, Haifa,; Israel.; STUDY OBJECTIVE: To gather direct observational data on anesthesiologists compliance with universal precautions gloving standards during induction of general anesthesia. DESIGN: Prospective, observational study. SETTING: Operating theaters of an Israeli government teaching hospital. SUBJECTS: Over a four-month perio
Role of surgery in multi-drug-resistant tuberculosis: results of 27 cases.: Eur J Cardiothorac Surg. 1997 Oct;12(4):531-4. Unique Identifier : AIDSLINE MED/98036161; Kir A; Tahaoglu K; Okur E; Hatipoglu T; Sureyyapasa Center for Chest Diseases and Thoracic Surgery,; Istanbul, Turkey.; OBJECTIVE: To evaluate the results of resectional surgery as an adjuvant therapy in multi-drug resistant tuberculosis. METHODS: A total of 27 human immunodeficiency virus (HIV)-negative patients with multi-drug resistant tuberculosis underwent resectional surgery between 1993 and 1996. The lesions were bilateral in 16
Child sexual abuse, HIV sexual risk, and gender relations of African-American women.: Am J Prev Med. 1997 Sep-Oct;13(5):380-4. Unique Identifier : AIDSLINE MED/97460889; Wingood GM; DiClemente RJ; Department of Health Behavior, School of Public Health,; University of Alabama, Birmingham 35294-0022, USA.; INTRODUCTION: A cross-sectional study was conducted to examine the association between childhood abuse, HIV-related sexual risks, and gender relations among African-American women. METHODS: The sample 165 African-American women, 18-29 years of age, were recruited by street outreach from a lower socioeconomic community
Quarterly Communicable Disease Review January to March 1997. From the PHLS Communicable Disease Surveillance Unit.: J Public Health Med. 1997 Sep;19(3):354-9. Unique Identifier : AIDSLINE MED/98007012; Hamilton G; Catchpole M; Bartlett CL; Lane C; Joseph C; Duckworth G
Letter from Zambia 'Naught for your comfort' [letter]: J Public Health Med. 1997 Sep;19(3):360-1. Unique Identifier : AIDSLINE MED/98007013; Sims P
Chimpanzee pathogenic strains of HIV type 1 [letter]: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1259. Unique Identifier : AIDSLINE MED/97479760; Prince AM
HIV type 1 strains pathogenic for chimpanzees [letter]: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1261. Unique Identifier : AIDSLINE MED/97479761; Fultz PN
IgA immunity in HIV type 1-infected chimpanzees. I. Systemic immunity.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1263-72. Unique Identifier : AIDSLINE MED/97479762; Black KP; Fultz PN; Girard M; Jackson S; Department of Microbiology, University of Alabama at Birmingham,; 35294-2170, USA.; HIV infection in humans causes various aberrancies in both the cellular and humoral immune systems, including functional abnormalities of B lymphocytes. In many instances, dysfunction occurs in the regulation of serum IgA, resulting in elevated concentrations of this immunoglobulin isotype. To determine whether HIV-1-
IgA immunity in HIV type 1-infected chimpanzees. II. Mucosal immunity.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1273-82. Unique Identifier : AIDSLINE MED/97479763; Black KP; Fultz PN; Girard M; Jackson S; Department of Microbiology, University of Alabama at Birmingham,; 35294-2170, USA.; Vaginal wash fluids from chimpanzees cervically infected with HIV-1 and saliva from intravenously and cervically infected chimpanzees were analyzed for total IgA, IgA1, IgA2, IgG, and albumin concentrations and for reactivity against HIV-1. No overt abnormalities were detected in salivary immunoglobulin or albumin con
Mutations of the HIV type 1 V3 loop under selection pressure with neutralizing monoclonal antibody NM-01.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1283-90. Unique Identifier : AIDSLINE MED/97479764; Yoshida K; Nakamura M; Ohno T; Department of Microbiology, The Jikei University School of; Medicine, Tokyo, Japan.; Variants of human immunodeficiency virus type 1 (HIV-1) were selected for resistance to the neutralizing monoclonal antibody (MAb) NM-01. MAb NM-01 recognizes the center of the third hypervariable domain (V3 loop) of the envelope gp120, and neutralizes diverse HIV-1 strains. In the continuous presence of MAb NM-01, tr
The V1/V2 region of human immunodeficiency virus type 1 modulates the sensitivity to neutralization by soluble CD4 and cellular tropism.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1291-9. Unique Identifier : AIDSLINE MED/97479765; Morikita T; Maeda Y; Fujii S; Matsushita S; Obaru K; Takatsuki K; The Second Department of Internal Medicine, Kumamoto University; School of Medicine, Japan.; A primary isolate (KMT) of human immunodeficiency virus type 1 (HIV-1) resistant to recombinant soluble CD4 (rsCD4) was isolated from an HIV-1-infected individual and grown in a T lymphoid cell line. KMT isolate passaged on CEM cells (KMT/CEM) was still resistant to rsCD4. The V1/V2 and V3 regions of the viral envelop
Longitudinal study of HIV-specific cytotoxic lymphocytes in HIV type 1-infected patients: relative balance between host immune response and the spread of HIV type 1 infection.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1301-12. Unique Identifier : AIDSLINE MED/97479766; Bariou C; Genetet N; Ruffault A; Michelet C; Cartier F; Genetet B; Groupe Universitaire de Recherche en Immunologie Fondamentale et; Appliquee, Universite de Rennes I, France.; To evaluate the contribution of a specific cytotoxic response in the control of HIV infection in relation to clinical status, we performed serial analysis of anti-Env and anti-Gag cytotoxic activity in 13 infected individuals over a 6- to 10-year period, using cryopreserved peripheral blood mononuclear cells (PBMCs).
HIV type 1 envelope glycoprotein 120 carboxy-terminal peptide-induced human T cell lines selectively suppress heterogeneous proliferative T cell responses to soluble antigens.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1313-24. Unique Identifier : AIDSLINE MED/97479767; Wilson SE; Habeshaw JA; Addawe MA; Hounsell EF; Oxford JS; Academic Virology, The London Hospital Medical College, UK.; swilson@hivnet.fhcrc.org; It has been proposed that the highly conserved human immunodeficiency virus type 1 (HIV-1) envelope gp120 carboxy-terminal sequence, TKAKRRVVEREKR (CT120), may represent a functional mimic of the human leukocyte antigen (HLA) class II DR beta-chain third hypervariable region (HVR3) sequence motif located at position 6
Selenium supplementation suppresses tumor necrosis factor alpha-induced human immunodeficiency virus type 1 replication in vitro.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1325-32. Unique Identifier : AIDSLINE MED/97479768; Hori K; Hatfield D; Maldarelli F; Lee BJ; Clouse KA; Division of Cytokine Biology, Center for Biologics Evaluation and; Research, Food and Drug Administration, Rockville, Maryland; 20852, USA.; Selenium is a nutritionally essential trace element that is important for optimal function of the immune system. It is incorporated into selenoproteins as the amino acid selenocysteine and it is known to inhibit the expression of some viruses. In this study, we show that selenium supplementation for 3 days prior to ex
Inhibition of FIV replication by a ribozyme that targets the Rev response element.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1333-9. Unique Identifier : AIDSLINE MED/97479769; Mergia A; Blackwell J; Chari S; Department of Pathobiology, College of Veterinary Medicine,; University of Florida, Gainesville 32610-0145, USA.; The feline immunodeficiency virus (FIV) Rev protein and its cognate sequence the Rev response element (RRE) are essential for virus replication. Thus, the inhibition of either Rev or RRE function can significantly inhibit FIV replication. In the present study, we constructed a ribozyme that targets the RRE sequence an
Fibronectin modulates endothelial response to HIV type 1 Tat.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1341-8. Unique Identifier : AIDSLINE MED/97479770; Cavallaro U; Mariotti M; Wu ZH; Soria MR; Maier JA; Department of Biological and Technological Research, San Raffaele; Institute, Milan, Italy.; The normal function of the endothelium is impaired in HIV-1 infection. Disturbances of the local cytokines as well as the release of HIV-1 Tat by infected mononuclear cells play a role in endothelial dysfunction. We studied the effects of Tat on the human endothelial ECV cell line. In this system, Tat inhibited cell p
Genetic variability of HIV type 1 in Honduras.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1349-50. Unique Identifier : AIDSLINE MED/97479771; Candal DH; Pau CP; Luo CC; Granade T; Stetler H; Amador L; Meza R; Nunez C; Schochetman G; George JR; Centers for Disease Control and Prevention, Public Health; Service, U.S. Department of Health and Human Services, Atlanta,; Georgia 30333, USA.
gag and env sequences of an A/G/H recombinant from a Zairian HIV type 1 isolate.: AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1351-4. Unique Identifier : AIDSLINE MED/97479772; Duchet S; Letourneur F; Loussert-Ajaka I; Chaplain C; Gomas E; Brun-Vezinet F; Simon F; Saragosti S; ICGM, Hopital Cochin, Institut A. Fournier, Paris, France.
The family with AIDS: multiple challenges for caregivers.: Am J Hosp Palliat Care. 1997 Nov-Dec;14(6):293-9. Unique Identifier : AIDSLINE MED/98054435; Williams E; Berrien V; Trubey P; East Hartford Visiting Nurse Association, Inc., Connecticut, USA.; Acquired Immune Deficiency Syndrome (AIDS) continues to increase in the United States , especially among minority groups. The disease is impacting not only individuals, but entire families through multiple infections of family members. This results in simultaneous illness and multiple l
Systemic infection by JC virus in non-HIV induced immunodeficiency without progressive multifocal leukoencephalopathy.: Ann Ital Med Int. 1997 Jan-Mar;12(1):35-8. Unique Identifier : AIDSLINE MED/97430407; Bordin G; Boldorini R; Caldarelli Stefano R; Omodeo-Zorini E; Divisione di Medicina Interna, Azienda Ospedaliera Maggiore della; Carita di Novara.; Reactivation of latent JC virus in immunodeficient subjects can lead to a demyelinating disease following lytic oligodendrocyte infection. It is known as idiopathic CD4+ lymphocytopenia and rarely occurs in immunosuppressed patients who are not infected by HIV. We describe a case of persistent idiopathic CD4+ lymphocy
Definition of pediatric asthma and associated risk factors.: Pediatr Pulmonol Suppl. 1997 Sep;15:9-12. Unique Identifier : AIDSLINE MED/97461820; Martinez FD; Department of Pediatrics, University of Arizona, Tucson, USA.; Significant advances have been made in recent years in understanding the different ways in which asthma is expressed during childhood. There is a large group of children (20% of the population) who present with wheezing during viral infections during the first 3 years of life but whose symptoms disappear after this ag
Toenail onychomycosis in patients with acquired immune deficiency syndrome: treatment with terbinafine.: Br J Dermatol. 1997 Oct;137(4):577-80. Unique Identifier : AIDSLINE MED/98052036; Herranz P; Garcia J; De Lucas R; Gonzalez J; Pena JM; Diaz R; Casado M; Department of Dermatology, La Paz University Hospital, Autonoma; University, Madrid, Spain.; Skin infections caused by dermatophytes are one of the most frequent dermatological complications in patients with acquired immunodeficiency syndrome (AIDS) resulting from infection with human immunodeficiency virus (HIV). Tinea unguium associated with AIDS is characterized by being clinically more aggressive and ther
The prevalence of skin disease in HIV infection and its relationship to the degree of immunosuppression.: Br J Dermatol. 1997 Oct;137(4):595-8. Unique Identifier : AIDSLINE MED/98052040; Uthayakumar S; Nandwani R; Drinkwater T; Nayagam AT; Darley CR; Department of Genitourinary Medicine, Royal Sussex County; Hospital, Brighton, U.K.; A cross-sectional study of human immunodeficiency virus (HIV) positive patients who attended the HIV clinic in Brighton over a 4-month period was carried out to describe the prevalence and severity of skin manifestations in HIV-positive patients and to elucidate their association with the peripheral CD4 cell count and
Aquagenic urticaria and human immunodeficiency virus infection: treatment with stanozolol.: Br J Dermatol. 1997 Oct;137(4):620-2. Unique Identifier : AIDSLINE MED/98052045; Fearfield LA; Gazzard B; Bunker CB; Department of Dermatology, Chelsea and Westminster Hospital,; London, U.K.; We report the first case of aquagenic urticaria in a patient with human immunodeficiency virus (HIV) infection. This is a rare physical urticaria not previously described in this context. The disorder proved unamenable to conventional treatment with antihistamines, but did respond dramatically to stanozolol, suggestin
Mycosis fungoides and Sezary syndrome are not associated with HTLV-I infection: an international study.: Br J Haematol. 1997 Sep;98(4):927-33. Unique Identifier : AIDSLINE MED/97465471; Bazarbachi A; Soriano V; Pawson R; Vallejo A; Moudgil T; Matutes E; Peries J; Molina A; de The H; Schulz TF; Catovsky D; Gill PS; UPR A0043 Hopital Saint-Louis, Paris, France.; Association between mycosis fungoides (MF), its leukaemic variant Sezary syndrome (SS) and the human T-cell lymphotropic virus type-I (HTLV-I) has been controversial, with the reported incidence of infection varying between 0% and nearly 100%. We studied 127 patients (85 MF, 28 SS, five Sezary cell leukaemia, four lym
The haematological features of HIV infection.: Br J Haematol. 1997 Oct;99(1):1-8. Unique Identifier : AIDSLINE MED/98022453; Bain BJ; Imperial College School of Medicine at St Mary's Hospital,; London.
Frequency of Bcl-2 rearrangements in peripheral blood of HIV-infected individuals [letter]: Br J Haematol. 1997 Nov;99(2):465-6. Unique Identifier : AIDSLINE MED/98041623; Liu Y; Cortopassi G; Goedert JJ; Rabkin CS
Application of human liver microsomes in metabolism-based drug-drug interactions: in vitro-in vivo correlations and the Abbott Laboratories experience.: Adv Pharmacol. 1997;43:65-101. Unique Identifier : AIDSLINE MED/98000220; Rodrigues AD; Wong SL; Drug Metabolism Department, Abbott Laboratories, Abbott Park,; Illinois 60064-3500, USA.
Prognosis of Kaposi's sarcoma as an initial and later AIDS associated illness.: Ann Oncol. 1997 Sep;8(9):871-5. Unique Identifier : AIDSLINE MED/98023842; Padiglione A; Goldstein D; Law MG; Hoy JF; Kaldor JM; Mijch AM; Fairfield Hospital, Melbourne, Australia.; BACKGROUND: The natural history of Kaposi s sarcoma (KS) as a primary presentation of AIDS has been well defined, but little is known about the prognosis of KS following a different AIDS defining illness (ADI). PATIENTS AND METHODS: Retrospective review of 852 consecutive individuals diagnosed with AIDS at Fairfield H
The association of complementary ribonucleic acids can be strongly increased without lowering Arrhenius activation energies or significantly altering structures.: Biochemistry. 1997 Nov 4;36(44):13552-7. Unique Identifier : AIDSLINE MED/98022748; Nedbal W; Homann M; Sczakiel G; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Heidelberg, Germany.; The association rates of complementary nucleic acids can be increased by 2-3 orders of magnitude in vitro by cellular proteins and low molecular weight compounds including cetyltrimethylammonium bromide (CTAB). In this work, we provide experimental evidence that the CTAB-mediated enhancement of RNA-RNA annealing by ap
RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase: evidence of discrimination between DNA and RNA substrates.: Biochemistry. 1997 Nov 18;36(46):14056-63. Unique Identifier : AIDSLINE MED/98039136; Kerr SG; Anderson KS; Department of Pharmacology, 333 Cedar Street, Yale University; School of Medicine, New Haven, Connecticut 06520-8066, USA.; The RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase has been investigated using pre-steady-state kinetics under single turnover conditions. In contrast to previous estimates of low replication fidelity of HIV-1 reverse transcriptase, the present study finds the enzyme to be more highly discrimina
Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance.: Biochemistry. 1997 Nov 18;36(46):14064-70. Unique Identifier : AIDSLINE MED/98039137; Kerr SG; Anderson KS; Department of Pharmacology, 333 Cedar Street, Yale University; School of Medicine, New Haven, Connecticut 06520-8066, USA.; There is lack of a correlation between biochemical studies and the observed clinical resistance of AIDS patients on long term AZT therapy. Mutant HIV-1 reverse transcriptase in the viral isolates from these patients shows a 100-fold decrease in sensit
Conformation of the trypanocidal pharmaceutical suramin in its free and bound forms: transferred nuclear overhauser studies.: Biochemistry. 1997 Nov 18;36(46):14202-17. Unique Identifier : AIDSLINE MED/98039153; Polenova T; Iwashita T; Palmer AG 3rd; McDermott AE; Department of Chemistry, Columbia University, New York, New York; 10027, USA.; Suramin is a lead compound for treatment of cancer, HIV, and trypanosomiasis. The conformations of suramin in its free form and bound to phosphoglycerate kinases from T. brucei and S. cerevisae, have been studied in aqueous solutions using nuclear Overhauser effect (NOE) and transferred NOE NMR spectroscopies. The NOE
Type and extent of myocardial injury related to brain damage and its significance in heart transplantation: a morphometric study.: J Heart Lung Transplant. 1997 Oct;16(10):994-1000. Unique Identifier : AIDSLINE MED/98027133; Baroldi G; Di Pasquale G; Silver MD; Pinelli G; Lusa AM; Fineschi V; Department of Cardiology De Gasperis, Niguarda Hospital,; University of Milan, Italy.; BACKGROUND: Focal myocardial necrosis reported in patients who died of brain lesions and in donor hearts soon after insertion has been attributed to catecholamine-related injury induced before operation, or in the perioperative period. Interpretation of the morphofunctional type of myocardial injury observed and its q
Effects on mollicutes (wall-less bacteria) of synthetic peptides comprising a signal peptide or a membrane fusion peptide, and a nuclear localization sequence (NLS) -- a comparison with melittin.: Biochim Biophys Acta. 1997 Oct 23;1329(2):357-69. Unique Identifier : AIDSLINE MED/98037478; Beven L; Chaloin L; Vidal P; Heitz F; Wroblewski H; Groupe Membranes et Osmoregulation, UPRES-A CNRS No. 6026,; Universite de Rennes 1, Campus de Beaulieu, France.; In order to investigate the effect of primary amphipathic peptides on mollicutes (wall-less bacteria), we have synthesised five molecules (P1, P2, P3, JM123, and JM133) comprising a 16 to 18-residue hydrophobic sequence and the nuclear localization sequence (NLS) PKKKRKV of simian virus 40 large-T antigen, C-terminate
Human salivary histatin-5 exerts potent fungicidal activity against Cryptococcus neoformans.: Biochim Biophys Acta. 1997 Oct 20;1336(3):367-9. Unique Identifier : AIDSLINE MED/98032985; Tsai H; Bobek LA; Department of Oral Biology, School of Dental Medicine, State; University of New York at Buffalo, 14214, USA.; Human salivary histatins (Hsns) have been known to be potent antifungal agents against Candida albicans for more than a decade. Here, we report that Hsns are also effective in killing another medically important opportunistic fungal pathogen, Cryptococcus neoformans, which has become a new threat among the immunocompr
Antigenic determination fragments of alpha-momorcharin.: Biochim Biophys Acta. 1997 Oct 20;1336(3):419-24. Unique Identifier : AIDSLINE MED/98032991; Leung KC; Meng ZQ; Ho WK; Department of Biochemistry, Chinese University of Hong Kong,; Shatin, N.T.; Alpha momorcharin is a protein isolated from the bitter gourd. It has a number of biological activities including induction of abortion, inhibition of tumor growth and anti-HIV. All these activities may be related to the ribosome-inhibiting activity of the protein. Repeated use of alphaMMC can elicit an antigenic resp
The inhibitory action of fatty acids on DNA polymerase beta.: Biochim Biophys Acta. 1997 Oct 20;1336(3):509-21. Unique Identifier : AIDSLINE MED/98033001; Mizushina Y; Yoshida S; Matsukage A; Sakaguchi K; Department of Applied Biological Science, Faculty of Science and; Technology, Science University of Tokyo, Japan.; We found previously that long-chain fatty acids could inhibit eukaryotic DNA polymerase activities in vitro [1,2]. The purpose of the present study was to investigate the mode of this inhibition in greater detail. Among the C18 to C24 fatty acids examined, the strongest inhibitor was a C24 fatty acid, nervonic acid (N
Members of the AAA-gene family are involved in early embryogenesis of vertebrates.: Biochim Biophys Acta. 1997 Oct 9;1354(1):1-6. Unique Identifier : AIDSLINE GENBANK/X81986; Nacken W; Institute of Experimental Dermatology, Munster Medical School,; Germany. nacken@uni-muenster.de; Here the nucleotide sequence of three cDNAs from Xenopus laevis are reported. The corresponding genes belong to the AAA-family of genes showing the strongest sequence homology to the human HIV-1 Tat binding protein 1 (TBP-1) and to the yeast SUG1 gene, respectively. Analysis of their expression pattern indicate that t
[Etiology of enteritis in a university general hospital in Barcelona (1992-1995)]: Enferm Infecc Microbiol Clin. 1997 Aug-Sep;15(7):349-56. Unique Identifier : AIDSLINE MED/98024677; Prats G; Llovet T; Munoz C; Sole R; Mirelis B; Izquierdo C; Rodriguez P; Sabanes ME; Rabella N; Pericas R; Sanchez F; Margall N; Navarro F; Coll P; Servicio de Microbiologia, Hospital de la Santa Creu i Sant Pau,; Universitat Autonoma de Barcelona.; BACKGROUND: The aim of the study was to describe the etiology of enteropathogenic agents over a four-year period (1992-1995) in a University Hospital in Barcelona. METHODS: We studied 12,793 stool samples, 4519 were obtained from patients under 15 years and 8274 were obtained from patients over 14 years. The specimens
[Intensive care for patients with the human immunodeficiency virus]: Enferm Infecc Microbiol Clin. 1997 Aug-Sep;15(7):373-7. Unique Identifier : AIDSLINE MED/98024682; Esteban J; Mateo O; Perez V; Perez G; Alvarez M; Melero J; Servicio de Medicina Interna, Hospital Universitario de Getafe,; Madrid.; BACKGROUND: HIV infection is of special importance in Spain , occasionally requiring the use of intensive care units (ICU) in the management of these cases. METHODS: A retrospective review of the seropositive HIV patients was carried out of those requiring ICU admission in the author
[HIV infection and porphyria cutanea tarda (letter)]: Enferm Infecc Microbiol Clin. 1997 Aug-Sep;15(7):392-3. Unique Identifier : AIDSLINE MED/98024690; Sanchez Angulo JI; Cuesta Lopez MJ; Zapata Lopez A; Perez Cortes S
[Severe community-acquired pneumonia]: Enferm Infecc Microbiol Clin. 1997 Oct;15 Suppl 3:41-6. Unique Identifier : AIDSLINE MED/98009349; Insausti J; Olaechea P; Barado J; Servicio de Medicina Intensiva, Hospital de Navarra,; Pamplona-Iruna.; There is no precise definition for severe community-acquired pneumonia (SEHP), but there are a number of factors which are associated with a greater severity, and which therefore recommended the admission of these patients in an intensive care unit (ICU). In the present article, we mainly refer to SEHP in the immune c
Measuring outcomes in genitourinary medicine: an introduction [editorial; comment]: Int J STD AIDS. 1997 Nov;8(11):661-2. Unique Identifier : AIDSLINE MED/98029965; Evans D; Patel R; Woodward N
Key issues in outcomes measurement [editorial] [see comments]: Int J STD AIDS. 1997 Nov;8(11):663-7. Unique Identifier : AIDSLINE MED/98029966; Long AF; Exploring and monitoring outcomes within routine clinical practice is central to high quality patient care. It is however a complex and challenging task. Multiple interests in outcomes information are apparent and different perspectives on what counts as an effective intervention or successful outcome. The paper p
The oral manifestations of HIV infection.: Int J STD AIDS. 1997 Nov;8(11):668-74. Unique Identifier : AIDSLINE MED/98029967; Robinson PG; Department of Oral Medicine and Pathology, United Medical School,; Guy's Hospital, London, UK.
The prevalence of serological markers for syphilis amongst a sample of Spanish prostitutes.: Int J STD AIDS. 1997 Nov;8(11):675-80. Unique Identifier : AIDSLINE MED/98029968; Estebanez P; Zunzunegui MV; Grant J; Fitch K; Aguilar MD; Colomo C; Pueyo I; Lorenzo M; London School of Hygiene and Tropical Medicine.; The results of a multicentre study of 1668 Spanish prostitutes are described with regard to syphilis infection. For those women who permitted serological tests (n = 1095), 30.59% (confidence interval (CI): 30.55%-30.63%) were positive for markers indicating current or prior infection. After adjustment was made for oth
Improvement in AIDS knowledge, perceptions and risk behaviours over a short period in a rural community of Senegal.: Int J STD AIDS. 1997 Nov;8(11):681-7. Unique Identifier : AIDSLINE MED/98029969; Lagarde E; Pison G; Enel C; Laboratoire d'Anthropologie Biologique (UMR 152, CNRS), Museum; National d'Histoire Naturelle, France.; The objective of this paper is to assess knowledge, perceptions and behavioural changes in response to AIDS in a rural community in the south of Senegal , comparing 2 cross-sectional surveys using standardized questionnaires and performed in 1990-1992 and 1994. An AIDS-related know
Awareness of sexually transmitted disease among women and service providers in rural Bangladesh.: Int J STD AIDS. 1997 Nov;8(11):688-96. Unique Identifier : AIDSLINE MED/98029970; Khan MA; Rahman M; Khanam PA; Barkat-e-Khuda; Kane TT; Ashraf A; MCH-FP Extension Project (Rural), International Centre for; Diarrhoeal Disease Research, Bangladesh (ICDDR,B).; Sexually transmitted disease (STD) in rural Bangladesh is currently a topic of great concern. To date, little information is available in the literature regarding its prevalence. It is now known, however, that the current level of STD awareness among the rural population with r
Infection by hepatitis B and C virus in female and transsexual Greek prostitutes with serological evidence of active syphilis.: Int J STD AIDS. 1997 Nov;8(11):697-9. Unique Identifier : AIDSLINE MED/98029971; Tsakris A; Kyriakis KP; Chryssou S; Papoutsakis G; Venereal Diseases Clinic, Ministry of Health, Athens, Greece.; Two hundred and thirty female and 43 male-to-female transsexual Greek prostitutes were screened for serological evidence of active syphilis as judged by positivity in both rapid plasma reagin (RPR) test and treponemal (FTA-ABS and TPHA) tests. The rate of active syphilis was 20.9% in the male-to-female transsexual pro
Indirect calorimetry, body composition and small bowel function in asymptomatic HIV-seropositive women.: Int J STD AIDS. 1997 Nov;8(11):700-3. Unique Identifier : AIDSLINE MED/98029972; Sharpstone D; Ross H; Hancock M; Phelan M; Crane R; Gazzard B; Department of HIV/GUM, Chelsea and Westminster Hospital, London,; UK.; Extrapolation of data from energy balance studies in HIV-seropositive men to HIV-seropositive women may be inaccurate due to gender differences in body composition, hormones and metabolism. If women have a different metabolic response to the human immunodeficiency virus (HIV), nutritional advice may differ from HIV-se
Prolonged survival with HIV-1 related nasal non-Hodgkin's lymphoma.: Int J STD AIDS. 1997 Nov;8(11):704-6. Unique Identifier : AIDSLINE MED/98029973; Dilke-Wing GM; Monteiro EF; Department of Genitourinary Medicine, General Infirmary, Leeds,; UK.
Anaphylactoid reaction to ciprofloxacin.: Int J STD AIDS. 1997 Nov;8(11):707-8. Unique Identifier : AIDSLINE MED/98029974; Clutterbuck DJ; McMillan A; Department of Medicine, Edinburgh Royal Infirmary, UK.
Is there a role for positron emission tomography scanning in HIV-positive patients with Kaposi's sarcoma and lymphadenopathy: two case reports.: Int J STD AIDS. 1997 Nov;8(11):709-12. Unique Identifier : AIDSLINE MED/98029975; Kulasegaram R; Saunders K; Bradbeer CS; O'Doherty M; Department of Genitourinary Medicine, St Thomas' Hospital,; London, UK.
Acceptability of genitourinary medicine services in Middlesbrough, England.: Int J STD AIDS. 1997 Nov;8(11):713-4. Unique Identifier : AIDSLINE MED/98029976; Opaneye AA; Department of Genitourinary Medicine, Middlesbrough General; Hospital, UK.
Moritz Kaposi (1837-1902).: Int J STD AIDS. 1997 Nov;8(11):715-7. Unique Identifier : AIDSLINE MED/98029977; Oriel JD; University College, London, UK.; Today, Kaposi is remembered for giving the first description of the angiosarcoma which bears his name. During his lifetime, he was acknowledged as one of the great masters of the Vienna School of Dermatology, a superb clinician and renowned teacher.
Attitudes towards HIV testing of patients attending hospital [letter]: Int J STD AIDS. 1997 Nov;8(11):729-30. Unique Identifier : AIDSLINE MED/98029978; McAdam C; Richardson A; Lewis S; Gore S; Brettle R
Heterosexual gonorrhoea and sexual behaviour [letter]: Int J STD AIDS. 1997 Nov;8(11):730. Unique Identifier : AIDSLINE MED/98029979; Opaneye A
Brain abscess.: Clin Infect Dis. 1997 Oct;25(4):763-79; quiz 780-1. Unique Identifier : AIDSLINE MED/98019635; Mathisen GE; Johnson JP; Infectious Disease Service, UCLA-Olive View Medical Center,; Department of Medicine, Sylmar, California 91342, USA.; The past 20 years have seen major advances in the diagnosis and management of brain abscess, with a corresponding improvement in the survival rates. The advances in radiographic scanning, the availability of new antimicrobials, and the development of novel surgical techniques have all contributed to the decreases in a
Human immunodeficiency virus/AIDS Medicaid managed care network.: Clin Infect Dis. 1997 Oct;25(4):803-4. Unique Identifier : AIDSLINE MED/98019638; Bartlett JG; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.
Point prevalence of oropharyngeal carriage of fluconazole-resistant Candida in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1997 Oct;25(4):843-6. Unique Identifier : AIDSLINE MED/98019647; Martins MD; Lozano-Chiu M; Rex JH; Department of Internal Medicine, University of Texas Medical; School, Houston, USA.; To estimate the prevalence of both clinically evident and asymptomatic carriage of fluconazole-resistant Candida, we prospectively surveyed 128 adults infected with human immunodeficiency virus (HIV). The patients had an average CD4 cell count of 206/mm3. Ninety-seven isolates of Candida were obtained from the orophar
Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation.: Clin Infect Dis. 1997 Oct;25(4):908-10. Unique Identifier : AIDSLINE MED/98019654; Marr KA; White TC; van Burik JA; Bowden RA; Division of Infectious Diseases, University of Washington,; Seattle Biomedical Research Institute.; Oral candidiasis due to azole-resistant Candida albicans is an increasing problem in patients with AIDS who received prolonged periods of fluconazole prophylaxis. Infection with C. albicans is also frequent in patients undergoing transplantation. However, azole resistance has not been appreciated as a major problem fo
Successful treatment of Edwardsiella tarda prosthetic valve endocarditis in a patient with AIDS.: Clin Infect Dis. 1997 Oct;25(4):918-9. Unique Identifier : AIDSLINE MED/98019657; Nettles RE; Sexton DJ; Department of Medicine, Duke University Medical Center, Durham,; North Carolina, USA.
Primary septic arthritis and osteomyelitis due to Mycobacterium avium complex in a patient with AIDS.: Clin Infect Dis. 1997 Oct;25(4):925-6. Unique Identifier : AIDSLINE MED/98019662; Sheppard DC; Sullam PM; Department of Medicine, Veterans Administration Medical Center,; San Francisco, USA.
Microsporidium species in pulmonary cavitary lesions of AIDS patients infected with Rhodococcus equi.: Clin Infect Dis. 1997 Oct;25(4):926-7. Unique Identifier : AIDSLINE MED/98019663; Lanzafame M; Bonora S; Di Perri G; Allegranzi B; Guasparri I; Cazzadori A; Ferrari S; Vento S; Concia E; Institute of Immunology and Infectious Diseases, University of; Verona, Italy. p6
Cervical cytomegalovirus infection in a woman with AIDS.: Clin Infect Dis. 1997 Oct;25(4):930-1. Unique Identifier : AIDSLINE MED/98019666; Walker N; Department of Internal Medicine, University of Cincinnati School; of Medicine, Ohio 45267-0535, USA.
Unusual prolonged hypocalcemia due to foscarnet in a patient with AIDS.: Clin Infect Dis. 1997 Oct;25(4):932-3. Unique Identifier : AIDSLINE MED/98019667; Guillaume MP; Karmali R; Bergmann P; Cogan E; Department of Internal Medicine, Hopital Universitaire Brugmann,; Universite Libre de Bruxelles, Belgium.
Hypertrophy of the breasts in a patient treated with indinavir.: Clin Infect Dis. 1997 Oct;25(4):937-8. Unique Identifier : AIDSLINE MED/98019671; Herry I; Bernard L; de Truchis P; Perronne C; Service des Maladies Infectieuses, Hopital de Garches, France.
Primary amebic meningoencephalitis in a patient with AIDS: unusual protozoological findings [letter; comment]: Clin Infect Dis. 1997 Oct;25(4):943-4. Unique Identifier : AIDSLINE MED/98019677; De Jonckheere JF; Brown S
Preface to the 1997 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. USPHS/IDSA Prevention of Opportunistic Infections Working Group.: Clin Infect Dis. 1997 Oct;25 Suppl 3:S299-312. Unique Identifier : AIDSLINE MED/98019679
1997 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: disease-specific recommendations. USPHS/IDSA Prevention of Opportunistic Infections Working Group.: Clin Infect Dis. 1997 Oct;25 Suppl 3:S313-35. Unique Identifier : AIDSLINE MED/98019680
Discovery and analysis of inhibitors of the human immunodeficiency integrase.: Drug Des Discov. 1997 May;15(1):17-24. Unique Identifier : AIDSLINE MED/97473986; Hazuda D; Felock PJ; Hastings JC; Pramanik B; Wolfe AL; Department of Antiviral Research, Merck Research Laboratories,; West Point, PA 19446, USA.; An essential step in the replication of retroviruses is the integration of a DNA copy of the viral genome into the genome of the host cell. Integration encompasses a series of ordered endonucleolytic and DNA strand transfer reactions catalyzed by the viral enzyme, integrase. The requirement for integrase activity in t
2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations.: Drug Des Discov. 1997 May;15(1):49-61. Unique Identifier : AIDSLINE MED/97473989; Domagala JM; Gogliotti R; Sanchez JP; Stier MA; Musa K; Song Y; Loo J; Reily M; Tummino P; Harvey P; Hupe D; Sharmeen L; Mack D; Scholten J; Saunders J; McQuade T; Department of Chemistry, Parke Davis Pharmaceutical Research,; Division of Warner Lambert Company, Ann Arbor, Michigan 48105,; USA.; Substituted 2,2 -dithiobisbenzamides and 2-benzisothiazolones were prepared and shown to possess low microM activity with high therapeutic indices against HIV-1, HIV-2 and SIV in cell culture. The mechanism of antiviral action was determined to be directed toward the nucleocapsid protein (NCp7), which contains two zin
[Frequency and characteristics of patients treated with zidovudine and absence of progression of HIV infection]: An Med Interna. 1997 Jun;14(6):282-5. Unique Identifier : AIDSLINE MED/97415874; Soriano V; Heredia A; Mas A; Vallejo A; Garcia-Lerma G; Bravo R; Gomez-Cano M; Villalba N; Moreno V; Laguna F; Valencia E; Martinez P; Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; BACKGROUND: the efficacy of zidovudine (ZDV) is lost in many treated individuals after a few weeks or months of monotherapy. The development of drug resistance seems to explain this adverse event. However, some individuals seem to persistently benefit clinically and immunologically from ongoing ZDV monotherapy. The de
[Treatment with interferon of chronic active hepatitis in patients with HIV infection]: An Med Interna. 1997 Jun;14(6):297-8. Unique Identifier : AIDSLINE MED/97415877; Pizarro Portillo A; Novella Arribas B; Sanz Sanz J; Servicio de Medicina Interna-Infecciosas, Hospital Universitario; de la Princesa, Madrid.; Clinical records of 14, CD4 cell counts > 400/mm3, mild symptoms or asymptomatic, HIV infected patients and with chronic active hepatitis (identified by hepatic biopsy) were under review. Four of them were infected with HBV, 8 with HCV, 1 with HDV and other one with HBV + HCV + HDV. They were treated with alpha interf
[Tuberculosis and HIV infection: pathogenesis (2nd of 3 parts)]: An Med Interna. 1997 Jun;14(6):310-6. Unique Identifier : AIDSLINE MED/97415882; Martinez Vazquez JM; Cabarcos Ortiz de Barron A; Barrio Gomez E; Servicio de Medicina Interna, Complejo Hospitalario Universitario; de Santiago, Santiago de Compostela, La Coruna.
[Course and prognosis of levels of CD4 molecules in HIV-infected patients]: An Med Interna. 1997 Jul;14(7):345-7. Unique Identifier : AIDSLINE MED/97410539; Pinilla Moraza J; Anton Botella F; Labarga Echeverria P; Sadaba Delgado C; Gimeno Villar C; Mugica Vargas M; Servicio de Medicina Interna, Complejo Hospitalario San; Millan-San Pedro, Logrono, La Rioja.; OBJECTIVE: To measure CD4 molecule concentration on lymphocyte surface. And observe its evolution during one year, in HIV infected patients. To assess the importance of this measure as a prognostic marker for disease progression, compared with the total number of CD4 lymphocytes. METHODS: Clinical and analytical data
[Cardiopathy and human immunodeficiency virus infection: report of 2 cases]: An Med Interna. 1997 Jul;14(7):357-9. Unique Identifier : AIDSLINE MED/97410543; Suarez Ortega S; Conde Martel A; Vargas Garcia R; Lopez y Juan L; Perez Correa S; Saade ME; Servicio de Medicina Interna, Complejo Hospitalario Las Palmas; Norte, Hospital El Sabinal, Las Palmas de Gran Canaria.; Two patients with immune deficiency virus infection and cardiac manifestation are presented. The first was admitted by encephalopathy. On the first days of hospital stay were observed episodes of supraventricular tachycardia with echocardiography normal. An initial improvement made us suppose the clinical context in r
[Tuberculosis and HIV infection: from clinical care to prevention (third of three parts)]: An Med Interna. 1997 Jul;14(7):363-8. Unique Identifier : AIDSLINE MED/97410545; Martinez Vazquez JM; Cabarcos Ortiz de Barron A; Barrio Gomez E; Servicio de Medicina Interna, Complejo Hospitalario Universitario; de Santiago, Santiago de Compostela, La Coruna.
[Treatment of drug dependence at the health center: 10 years' experience (editorial)]: Aten Primaria. 1997 Sep 15;20(4):159-60. Unique Identifier : AIDSLINE MED/98011091; Mendive Arbeloa JM
[Social work students' knowledge about HIV (letter)]: Aten Primaria. 1997 Sep 15;20(4):209-10. Unique Identifier : AIDSLINE MED/98011101; Sainz Martin M; Rodriguez Caravaca G; Hernandez Martin G; Morales Loro I; Villar del Campo I; Ferreres Castiel J
Permeabilization and fusion of uncharged lipid vesicles induced by the HIV-1 fusion peptide adopting an extended conformation: dose and sequence effects.: Biophys J. 1997 Oct;73(4):1977-86. Unique Identifier : AIDSLINE MED/97475942; Pereira FB; Goni FM; Muga A; Nieva JL; Department of Biochemistry and Molecular Biology, University of; the Basque Country, Bilbao, Spain.; The peptide HIV(arg), corresponding to a sequence of 23 amino acid residues at the N-terminus of HIV-1 gp41 (LAV1a strain), has the capacity to destabilize negatively charged large unilamellar vesicles. As revealed by infrared spectroscopy, the peptide associated with those vesicles showed conformational polymorphism:
Graphs in sequence spaces: a review of statistical geometry.: Biophys Chem. 1997 Jun 30;66(2-3):111-31. Unique Identifier : AIDSLINE MED/98028764; Nieselt-Struwe K; Institut f. Zoologie, Univ. Munchen, Germany.; Statistical geometry is a method of comparative sequence analysis of genes. Based on the concept of the sequence space of nucleic acids it computes the geometries of sequence sets, mainly quartets, by combining both the vertical and horizontal information content of the sequences. The geometries can be used to deduce,
Kinetic investigations by fluorescence correlation spectroscopy: the analytical and diagnostic potential of diffusion studies.: Biophys Chem. 1997 Jun 30;66(2-3):211-28. Unique Identifier : AIDSLINE MED/98028768; Schwille P; Bieschke J; Oehlenschlager F; Max-Planck-Institut fur Biophysikalische Chemie, Abteilung; Biochemische Kinetik, Gottingen, Germany.; This review demonstrates the large analytical and diagnostic potential of fluorescence correlation spectroscopy applied to freely diffusing biomolecules in solution. All applications discussed here in detail are based on changes in the diffusion characteristics of fluorescenctly labeled complementary strands of nuclei
Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer.: Biopolymers. 1997;44(2):125-38. Unique Identifier : AIDSLINE MED/98016377; Ding J; Hughes SH; Arnold E; Center for Advanced Biotechnology and Medicine (CABM),; Piscataway, NJ, USA.; The conformation of the DNA and the interactions of the nucleic acid with the protein in a complex of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and 19-mer/18-mer double-stranded DNA template-primer (dsDNA) are described. The structure of this HIV-1 RT complex with dsDNA serves as a useful
Natural killer T cells: a potent cytokine-producing cell population.: Eur Cytokine Netw. 1997 Sep;8(3):229-37. Unique Identifier : AIDSLINE MED/98004340; Leite-de-Moraes MC; Dy M; CNRS URA 1461, Universite Rene-Descartes, Paris V, France.; Natural killer (NK) T cells constitute a subset of TCRalphabeta+ T lymphocytes characterized by natural killer surface receptor expression as well as by a restricted TCR repertoire. This population is capable both of secreting several cytokines, especially IL-4 and IFN-gamma, shortly after stimulation and of killing t
Biological properties and therapeutic applications of interleukin-12.: Eur Cytokine Netw. 1997 Sep;8(3):305-7. Unique Identifier : AIDSLINE MED/98004355; Trinchieri G; The Wistar Institute, Philadelphia, PA 19014, USA.
Immunointervention based on Th2-type cytokines in HIV infection.: Eur Cytokine Netw. 1997 Sep;8(3):315-6. Unique Identifier : AIDSLINE MED/98004358; Galanaud P; Fior R; Boue F; Emilie D; Unite INSERM 131 et Service de Medecine Interne et Immunologie; Clinique, Hopital Antoine-Beclere, Institut Paris-Sud sur les; Cytokines, Clamart, France.
Will a presidential public apology be needed for HIV/AIDS care in the future? [editorial]: J Assoc Nurses AIDS Care. 1997 Nov-Dec;8(6):27-8. Unique Identifier : AIDSLINE MED/98019811; Porche DJ
Correlates of spiritual well-being in terminally ill persons with AIDS and terminally ill persons with cancer.: J Assoc Nurses AIDS Care. 1997 Nov-Dec;8(6):31-42. Unique Identifier : AIDSLINE MED/98019812; Pace JC; Stables JL; Emory University, Atlanta, Georgia, USA.; In an effort to determine if terminally ill patients with AIDS had greater religious and spiritual care needs than other terminally ill patient populations, particularly those with cancer, a study was conducted in a community-based hospice in the southeast. The purpose of the study was to compare the perceptions of sp
Reconstruction case management.: J Assoc Nurses AIDS Care. 1997 Nov-Dec;8(6):43-5. Unique Identifier : AIDSLINE MED/98019813; Sowell RL
Development of an HIV educational needs assessment tool.: J Assoc Nurses AIDS Care. 1997 Nov-Dec;8(6):46-51. Unique Identifier : AIDSLINE MED/98019814; Nokes KM; Kendrew J; Rappaport A; Jordan D; Rivera L; CUNY Hunter College, USA.; The learning needs of persons with HIV/AIDS continue to grow more complex as new treatments are developed and HIV disease shifts from being a terminal to a chronic illness. Clinicians could use a simple tool to help them to focus on what clients think is important to know about living with HIV/AIDS. This article descr
The role of self-esteem in safer sexual practices.: J Assoc Nurses AIDS Care. 1997 Nov-Dec;8(6):64-70. Unique Identifier : AIDSLINE MED/98019815; Cole FL; University of Texas-Houston Health Science Center, School of; Nursing, USA.; Self-esteem appears in the literature as a variable that influences the practice of risky sexual behaviors. It is often assumed that higher levels of self-esteem are associated with safer sexual behaviors, especially those that prevent the spread of HIV. The research literature was reviewed to examine the relationship
Nutritional issues and HIV/AIDS: assessment and treatment strategies.: J Assoc Nurses AIDS Care. 1997 Nov-Dec;8(6):71-80. Unique Identifier : AIDSLINE MED/98019816; Walsek C; Zafonte M; Bowers JM; NIH National Cancer Institute, USA.; Ongoing nutritional assessment is vital in the care of adults and children with HIV infection. Nutritional deficiency is a common manifestation of HIV disease and results from a variety of factors. Nurses caring for individuals with HIV infection in a variety of settings can be instrumental in identifying nutritional
Ritonavir (Norvir).: J Assoc Nurses AIDS Care. 1997 Nov-Dec;8(6):81-3. Unique Identifier : AIDSLINE MED/98019817; Porche DJ; Nicholls State University, Thibodaux, Louisiana, USA.
Heterosexual transmission of HIV in women.: J Assoc Nurses AIDS Care. 1997 Nov-Dec;8(6):84-7. Unique Identifier : AIDSLINE MED/98019818; Gaskins SW; Capstone College of Nursing, University of Alabama, Tuscaloosa,; USA.
Adherence as a particular issue with protease inhibitors.: J Assoc Nurses AIDS Care. 1997;8 Suppl:10-7. Unique Identifier : AIDSLINE MED/98019805; Katzenstein DA; Stanford University Medical Center, CA, USA.; Suboptimal therapeutic doses of HIV protease inhibitors lead to the emergence of drug resistance and reduced drug efficacy. It is imperative, then, that patients and clinicians alike are fully educated about the importance of patients taking all the pills in these n
Antiretroviral therapy: factors associated with adherence.: J Assoc Nurses AIDS Care. 1997;8 Suppl:18-23. Unique Identifier : AIDSLINE MED/98019806; Williams A; Yale School of Nursing, New Haven, CT, USA.; Clinical effectiveness of the new highly active antiretroviral therapies depends in large part on patients ability to adhere to demanding medication regimens because the suboptimal drug levels associated with nonadherence are, in turn, associated with the development of antiretroviral resistance. However, definitions
The case manager's role in adherence.: J Assoc Nurses AIDS Care. 1997;8 Suppl:24-8. Unique Identifier : AIDSLINE MED/98019807; Wolfe GS; Physician Disease Management, Washington, DC, USA.; The nurse as case manager has a responsibility to help patients become fully informed before making decisions about specific antiretroviral therapy regimens. In addition, the case manager can help patients assess their current situation with regard to the possibility of taking and adhering to complex antiretroviral re
HIV drug adherence: special situations.: J Assoc Nurses AIDS Care. 1997;8 Suppl:29-36. Unique Identifier : AIDSLINE MED/98019808; Lyons C; San Francisco General Hospital, USA.; Among the highly diverse population of persons living with HIV/AIDS are individuals with particularly challenging life circumstances that can be called special situations. Substance abuse and homelessness are examples of special situations that require additional consideration when attempting to determine the approp
Adherence to prescribed HIV-1 protease inhibitors in the home setting.: J Assoc Nurses AIDS Care. 1997;8 Suppl:37-45. Unique Identifier : AIDSLINE MED/98019809; Ungvarski P; HIV Infection Visiting Nurse Service of New York, USA.; The issue of adherence to any therapy prescribed by a health care provider is multidimensional and includes personal challenges that exist in the daily life of any client, as well as the individual practices and attitudes of the health care provider. In addition, since most health is delivered in congregate settings s
HIV therapeutics: confronting adherence.: J Assoc Nurses AIDS Care. 1997;8 Suppl:46-58. Unique Identifier : AIDSLINE MED/98019810; Katzenstein DA; Lyons C; Molaghan JP; Ungvarski P; Wolfe GS; Williams A; Stanford University Medical Center, CA, USA.
Adherence issues in HIV therapeutics. Introduction: the situation.: J Assoc Nurses AIDS Care. 1997;8 Suppl:7-9. Unique Identifier : AIDSLINE MED/98019804; Molaghan JB; AIDS Clinic, San Francisco General Hospital, USA.
Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma.: Blood. 1997 Dec 1;90(11):4278-82. Unique Identifier : AIDSLINE MED/98043616; Said JW; Rettig MR; Heppner K; Vescio RA; Schiller G; Ma HJ; Belson D; Savage A; Shintaku IP; Koeffler HP; Asou H; Pinkus G; Pinkus J; Schrage M; Green E; Berenson JR; Departments of Pathology and Medicine, the Division of; Hematology/Oncology, UCLA School of Medicine, Veterans Affairs; West Los Angeles Medical Center, Los Angeles, CA, USA.; We have recently demonstrated the presence of Kaposi s sarcoma-associated herpesvirus (KSHV) in cultured bone marrow (BM) stromal dendritic cells from all patients with myeloma studied. To show that these findings were not an artifact of tissue culture, we performed in situ hybridization (ISH) and polymerase chain rea
Gene transfer into marrow repopulating cells: comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons.: Blood. 1997 Dec 1;90(11):4638-45. Unique Identifier : AIDSLINE MED/98043655; Kiem HP; Heyward S; Winkler A; Potter J; Allen JM; Miller AD; Andrews RG; Clinical Research and Molecular Medicine Divisions, Fred; Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.; Many diseases might be treated by gene therapy targeted to the hematopoietic system, but low rates of gene transfer achieved in humans and large animals have limited the application of this technique. We have developed a competitive hematopoietic repopulation assay in baboons to evaluate methods for improving gene tra
Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in mice.: Blood. 1997 Dec 1;90(11):4651-60. Unique Identifier : AIDSLINE MED/98043657; Yang YG; Sergio JJ; Pearson DA; Szot GL; Shimizu A; Sykes M; BMT Section, Transplantation Biology Research Center, Surgical; Service, Massachusetts General Hospital/Harvard Medical School,; Boston, MA 02129, USA.; We have recently demonstrated that a single injection of 4,900 IU of interleukin-12 (IL-12) on the day of bone marrow transplantation (BMT) markedly inhibits acute graft-versus-host disease (GVHD) in a fully major histocompatibility complex plus minor antigen-mismatched BMT model (A/J --> B10, H-2(a) --> H-2(b)), in w
[A survey on sexual awareness and behaviour of residents of a provincial city]: Nippon Koshu Eisei Zasshi. 1997 Jul;44(7):499-508. Unique Identifier : AIDSLINE MED/97460290; Uchino H; Omachi Health Center, Nagano Prefecture.; For better understanding of the sexual behaviours that are high-risk in terms of HIV infection, a random sample of 200 people aged above 20 and below 60 years, from a population of 23,700, was selected in the provincial city of Nagano and surveyed by visitation. The responses of 156 people (a rate of response of 78%)
AIDS in Croatia compared with global HIV status [letter]: Acta Paediatr. 1997 Sep;86(9):1025. Unique Identifier : AIDSLINE MED/98001460; Rojnic N; Putarek K; Vuk T; Gjenero-Margan I; Grgicevic D; Malcic I
Errors of homeostasis and deregulated apoptosis.: Curr Opin Genet Dev. 1997 Oct;7(5):589-96. Unique Identifier : AIDSLINE MED/98050127; Rinkenberger JL; Korsmeyer SJ; Department of Anatomy, University of California, San Francisco; 94143-0750, USA. rinken@itsa.ucsf.edu; Apoptosis research has accelerated with the discovery of genes within a common cell death pathway and evidence for their inter-relationship. Breakthroughs include insights into the mechanism of action of the Bcl-2 family, caspases and their targets, and death receptor complexes. Deregulation of apoptosis is evident in
The potential for heparin and its derivatives in the therapy and prevention of HIV-1 infection.: Glycoconj J. 1997 Aug;14(5):639-42. Unique Identifier : AIDSLINE MED/97442148; Rider CC; Division of Biochemistry, Royal Holloway University of London,; Egham, Surrey, UK. c.rider@vms.rhbnc.ac.uk; Heparin is one of several sulphated polysaccharides which potently inhibit replication of the human immunodeficiency virus type 1 (HIV-1) in cultures of CD4+ve human cells. The EC50 value is around 5 microg ml(-1). We have demonstrated that heparin binds to recombinant gp120, the envelope glycoprotein of HIV-1, at a s
Protective roles of eosinophils in Nippostrongylus brasiliensis infection.: Int Arch Allergy Immunol. 1997 Oct;114 Suppl 1:45-50. Unique Identifier : AIDSLINE MED/98028555; Shin EH; Osada Y; Chai JY; Matsumoto N; Takatsu K; Kojima S; Department of Parasitology, Institute of Medical Science,; University of Tokyo, Japan.; Nippostrongylus brasiliensis infection is characterized by blood and tissue eosinophilia induced by interleukin (IL)-5 secreted from CD4+ T cells. However, it is still obscure whether eosinophils play an important role in the protection against N. brasiliensis infection. In this study we attempted to determine whether
[African histoplasmosis with ganglionic localisation. Apropos of 1 case in an HIV negative patient]: Bull Soc Pathol Exot. 1997;90(3):182-3. Unique Identifier : AIDSLINE MED/98023870; Koffi N; Boka JB; Anzouan-Kacou JB; Aka-Danguy E; Service de pneumologie, CHU de Cocody, Abidjan, Cote d'Ivoire.; This study concerns one case of ganglionary African histoplasmosis observed in a pregnant woman. The diagnosis of this histoplasmosis case has been based on histological presentation. This patient has a HIV negative serologic reaction. The histoplasmosis clinical presentation is like tuberculosis, so its diagnosis is
[Buschke-Loewenstein tumor. Apropos of 2 cases in Cotonou, Benin]: Bull Soc Pathol Exot. 1997;90(3):184-5. Unique Identifier : AIDSLINE MED/98023871; Yedomon HG; Hodonou R; Do Ango-Padonou F; Akpo C; Goudote E; Bourlond A; Service de dermatologie, C.N.H.U., Cotonou, Benin.; About two cases of Buschke-Loewenstein tumor--one of the penis in man infected with HIV and another of perianal area-, the authors insist on the relative frequency of Buschke-Loewenstein tumor in non-circumcised and homosexual groups. They emphasize the continuous precancerous spectrum of Buschke-Loewenstein tumor.
[Bullous toxidermatosis and HIV infection in hospital environment in Lome (Togo)]: Bull Soc Pathol Exot. 1997;90(3):186-8. Unique Identifier : AIDSLINE MED/98023872; Pitche P; Ategbo S; Gbadoe A; Bassuka-Parent A; Mouzou B; Tchangai-Walla K; Service de dermatologie-venereologie, CHU-Tokion, Lome, Togo.; A transversal study allowed to analyse the different features of severe bullous toxicodermatosis, and its relations with HIV infection. Since March 1992 to December 1995, 15 patients were hospitalized in Lome Teaching Hospital for severe bullous toxicodermatosis: 16 cases of Lyell s syndrome, 8 cases of Stevens-Johnso
Fatigue and depression: assessment in human immunodeficiency virus disease.: Nurse Pract Forum. 1997 Sep;8(3):121-5. Unique Identifier : AIDSLINE MED/98045496; Soucy MD; University of Texas Health Science Center at San Antonio, USA.; Fatigue and depression have devastating and debilitating effects on functional status, social and occupational functioning, and quality of life in persons with human immunodeficiency virus disease. Contributing factors involved are multifaceted and bidirectional in nature. Thorough assessment of fatigue and depression
Ethics and international research [editorial]: BMJ. 1997 Oct 18;315(7114):965-6. Unique Identifier : AIDSLINE MED/98031991; Halsey NA; Sommer A; Henderson DA; Black RE
Improving ethnic data within surveillance must be priority [letter]: BMJ. 1997 Nov 1;315(7116):1160. Unique Identifier : AIDSLINE MED/98042315; Nicoll A; Catchpole M; Watson JM
Prevalence of HIV-1 infection among heterosexual men and women attending genitourinary clinics in Scotland: unlinked anonymous testing.: BMJ. 1997 Nov 15;315(7118):1281-2. Unique Identifier : AIDSLINE MED/98051495; Scott G; Goldberg D; Weir M; Cameron S; Peutherer J; Carrington D; Follett E; Leadbetter G; Scoular A; Department of Genitourinary Medicine, Royal Infirmary, Edinburgh.
Multidrug resistant tuberculosis and HIV: a personal experience.: BMJ. 1997 Nov 15;315(7118):1317. Unique Identifier : AIDSLINE MED/98051526; Mayho P
Clinical indications of multiple integrations of human T-cell lymphotropic virus type I proviral DNA in adult T-cell leukemia/lymphoma.: Leuk Lymphoma. 1997 Sep;27(1-2):43-51. Unique Identifier : AIDSLINE MED/98039032; Shimamoto Y; Department of Internal Medicine, Saga Medical School, Nabeshima,; Japan.; In this review, we discuss the possible relationship between the clinical characteristics and the multiple integration of human T-cell lymphotropic virus type I (HTLV-I) proviral DNA in patients with adult T-cell leukemia/lymphoma (ATL). Some patients with ATL show multiple HTLV-I integrations and exhibit clinical cha
Viral gene expression and pathogenesis in three emerging diseases: HIV and AIDS; HTLV-I and HAM/TSP; and HHV-8 and Kaposi's sarcoma.: FEMS Immunol Med Microbiol. 1997 Aug;18(4):301-5. Unique Identifier : AIDSLINE MED/98006389; Haase AT; Department of Microbiology, University of Minnesota UMHC196,; Minneapolis 55455, USA. ashley@lenti.med.umn.edu
Emerging parasitic infections.: FEMS Immunol Med Microbiol. 1997 Aug;18(4):313-7. Unique Identifier : AIDSLINE MED/98006391; James SL; Division of Microbiology and Infectious Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, MD 20892, USA. sj13Y@nih.gov
Repair of an osteochondral tumor of the talus utilizing a fresh-frozen cadaveric graft.: J Foot Ankle Surg. 1997 Sep-Oct;36(5):375-80; discussion 396. Unique Identifier : AIDSLINE MED/98019765; Thomas MI; Anderson JC; Hatch DJ; McGarry JJ; Stone PA; Paden MH; Presbyterian/St. Lukes Podiatric Surgical Residency Program,; Denver, Colorado, USA.; A case involving a benign osteochondral tumor of the talar dome is presented. Graft considerations are reviewed and some of their specific characteristics are highlighted. Selection of a fresh-frozen cadaveric graft in this case was based on the goal of maintaining articular congruity in the ankle joint. The authors
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors.: Nat Genet. 1997 Nov;17(3):314-7. Unique Identifier : AIDSLINE MED/98016416; Kafri T; Blomer U; Peterson DA; Gage FH; Verma IM; Laboratory of Genetics, Salk Institute, La Jolla, California; 92037, USA.; Successful gene therapy approaches will require efficient gene delivery and sustained expression of the transgene in recipients. A variety of methods, ranging from direct DNA delivery to infection with recombinant viruses containing foreign genes, have been developed, but they all have some major limitations that rest
The confidentiality of HIV-related information: Pennsylvania's Act 148.: Medsurg Nurs. 1997 Oct;6(5):294-5. Unique Identifier : AIDSLINE MED/98045464; Tyler JM; Schubert, Bellwoar, Cahill & Quinn, Philadelphia, PA, USA.
[HIV virus detection in ejaculates collected at different times in seropositive patients]: Contracept Fertil Sex. 1997 Sep;25(9):725-9. Unique Identifier : AIDSLINE MED/98023522; Brechard N; Galea P; Silvy F; Amram M; Chermann JC; Laboratoire d'Analyses de Biologie Medicale, Marseille.; Ejaculates from 22 seropositive males were collected at various times 1 to 11 ejaculates for each in one year period of time. After fractionation, no virus is detected in mobile and living spermatozoa. Moreover, HIV is not always found in all ejaculates from the same patient.
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1997 Sep 26;7(39):355-6. Unique Identifier : AIDSLINE MED/98005743
Changes in the incidence of AIDS and in AIDS deaths: the effects of antiretroviral treatment.: Commun Dis Rep CDR Wkly. 1997 Oct 24;7(43):381. Unique Identifier : AIDSLINE MED/98019981
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1997 Oct 24;7(43):389-92. Unique Identifier : AIDSLINE MED/98019983
PNG on verge of AIDS epidemic [news]: Aust Nurs J. 1997 Oct;5(4):16. Unique Identifier : AIDSLINE MED/98047622
Follicular dendritic cell sarcoma complicated by hyaline-vascular type Castleman's disease in a schizophrenic patient.: Pathol Int. 1997 Oct;47(10):703-6. Unique Identifier : AIDSLINE MED/98026959; Katano H; Kaneko K; Shimizu S; Saito T; Irie T; Mori S; Department of Pathology, Omiya Red Cross Hospital, Japan.; katano@Ims.u-tokyo.ac.jp; Follicular dendritic cell (FDC) sarcoma is an exceedingly rare neoplasm of unknown pathogenesis. A case of FDC sarcoma complicated by the hyaline-vascular type Castleman s disease occurring in a schizophrenic male is presented. Swelling of the left cervical lymph node appeared in a 44-year-old male schizophrenic who h
[Educational communication between nurses and students about sexual health promotion]: Rev Lat Am Enfermagem. 1997 Jul;5(3):71-81. Unique Identifier : AIDSLINE MED/98038104; Oliveira MA; Bueno SM; Escola de Enfermagem de Ribeirao Preto, Universidade de Sao; Paulo.; As school has been a crucial space for the development of knowledge and abilities in order to assure changes of behavior and considering the lack of reports about sexuality and STD/AIDS to the students, the present study aims to search scholars from three classes of high school, from a town surrounding the city of Rib
Effect of a mistletoe extract (Iscador QuFrF) on viability and migratory behavior of human peripheral CD4+ and CD8+ T lymphocytes in three-dimensional collagen lattices.: In Vitro Cell Dev Biol Anim. 1997 Oct;33(9):710-6. Unique Identifier : AIDSLINE MED/98023124; Nikolai G; Friedl P; Werner M; Niggemann B; Zanker KS; Institute of Immunology, University of Witten/Herdecke, Germany.; Migration and tissue distribution of immunocompetent cells may be critical prerequisites for efficient immune surveillance. The effect of various concentrations of the mistletoe extract Iscador QuFrF on the locomotory behavior and viability of immunomagnetically isolated human CD4+ and CD8+ T lymphocytes within three-
Reality is hard to ignore.: Revolution. 1997 Fall;7(3):48-9. Unique Identifier : AIDSLINE MED/98046169; Arnold LM
The effect of segmental bronchoprovocation with allergen on airway lymphocyte function.: Am J Respir Crit Care Med. 1997 Nov;156(5):1421-8. Unique Identifier : AIDSLINE MED/98039924; Kelly EA; Rodriguez RR; Busse WW; Jarjour NN; Department of Medicine, University Wisconsin School of Medicine,; Madison 53972, USA.; We hypothesized that allergen-induced airway eosinophilia is linked to activation or recruitment of T cells in the airway and generation of interleukin-5 (IL-5). To evaluate this hypothesis, we performed bronchoscopy with segmental antigen bronchoprovocation in 12 atopic subjects. Bronchoalveolar lavage (BAL) was done
Tuberculosis control policies in major metropolitan health departments in the United States. VI. Standard of practice in 1996.: Am J Respir Crit Care Med. 1997 Nov;156(5):1487-94. Unique Identifier : AIDSLINE MED/98039934; Leff DR; Leff AR; Medill School of Journalism, Northwestern University, Evanston,; Illinois, USA.; Since 1980, we have surveyed at 4-yr intervals the metropolitan health departments initially reporting > 250 cases of tuberculosis to determine the perceived standard of practice for tuberculosis control and the factors affecting formulation of treatment policies. Between 1992 and 1996, use of supervised short-course
Role of bronchoalveolar lavage in predicting survival of patients with human immunodeficiency virus infection.: Am J Respir Crit Care Med. 1997 Nov;156(5):1501-7. Unique Identifier : AIDSLINE MED/98039936; Agostini C; Adami F; Poulter LW; Israel-Biet D; Freitas e Costa M; Cipriani A; Sancetta R; Lipman MC; Juvin K; Teles-Araujo AD; Cadrobbi P; Masarotto G; Semenzato G; Padua University School of Medicine, Department of Clinical and; Experimental Medicine, Italy.; In this multicenter study, we investigated the prognostic factors that influence the risk of death in patients with human immunodeficiency virus (HIV) infection. Clinical and laboratory indices obtained from 161 HIV-seropositive patients who underwent a detailed morphologic and immunophenotypic evaluation of bronchoal
Sarcoidosis: TNF-alpha release from alveolar macrophages and serum level of sIL-2R are prognostic markers.: Am J Respir Crit Care Med. 1997 Nov;156(5):1586-92. Unique Identifier : AIDSLINE MED/98039949; Ziegenhagen MW; Benner UK; Zissel G; Zabel P; Schlaak M; Muller-Quernheim J; Research Center Borstel, Medical Hospital, Germany.; At the time of diagnosis, many sarcoidosis patients have no clinical indication for corticosteroid therapy, and prognostic parameters predicting deterioration are missing. In the present study, we investigated parameters derived from bronchoalveolar lavage (BAL) and serum in 77 patients with recently diagnosed sarcoid
TCR V beta families in T cell clones from sarcoid lung parenchyma, BAL, and blood.: Am J Respir Crit Care Med. 1997 Nov;156(5):1593-600. Unique Identifier : AIDSLINE MED/98039950; Zissel G; Baumer I; Fleischer B; Schlaak M; Muller-Quernheim J; Research Center Borstel, Medical Hospital, Germany.; The TCR repertoire and the CD4/CD8 ratio of clones from peripheral blood (PB), transbronchial biopsies (TBB), and bronchoalveolar lavage (BAL) of 16 sarcoid patients was analyzed by staining the clones with monoclonal antibodies against nine V beta-families. We observed a striking increase in the CD4/CD8 ratio of the
Inflammatory cells in the bronchial glands of smokers with chronic bronchitis.: Am J Respir Crit Care Med. 1997 Nov;156(5):1633-9. Unique Identifier : AIDSLINE MED/98039956; Saetta M; Turato G; Facchini FM; Corbino L; Lucchini RE; Casoni G; Maestrelli P; Mapp CE; Ciaccia A; Fabbri LM; Institute of Occupational Medicine, University of Padua, Italy.; To characterize the inflammatory process in the bronchial glands of smokers with chronic sputum production, we examined lobar bronchi from 18 subjects undergoing lung resection for localized pulmonary lesions, all with a history of cigarette smoking. Nine of the subjects had symptoms of chronic bronchitis and chronic
HIV/AIDS in aging: concerns and challenges.: S C Nurse. 1996 Apr-Jun;3(2):17, 20-1. Unique Identifier : AIDSLINE MED/98052965; Murrow E; School of Nursing Clemson University, USA.
HIV, hepatitis--B, hepatitis--C, blood-borne diseases nurses' risks, rights, and responsibilities.: S C Nurse. 1996 Apr-Jun;3(2):35. Unique Identifier : AIDSLINE MED/98052972
[Anthropometric characteristics of HIV infected malnourished children in Ivory Coast]: Sante. 1997 Jul-Aug;7(4):236-8. Unique Identifier : AIDSLINE MED/98015318; Beau JP; Imboua-Coulibaly L; CHU de Treichville, Abidjan, Cote d'Ivoire.; Stunting and weight-loss are common complications of HIV infection in children. The aim of this study was to assess whether stunting, assessed using a height-for-age index, is a discriminating factor for HIV in malnourished children. This is a retrospective study of 66 children, all older than 15 months, with marasmus
[Human intestinal microsporidiosis in Bamako (Mali): the presence of Enterocytozoon bieneusi in HIV seropositive patients]: Sante. 1997 Jul-Aug;7(4):257-62. Unique Identifier : AIDSLINE MED/98015322; Maiga I; Doumbo O; Dembele M; Traore H; Desportes-Livage I; Hilmarsdottir I; Giboyau E; Maiga L; Kassambara L; el Fakhry Y; Datry A; Gentilini M; Pichard E; Laboratoire de biologie medicale, Hopital national du Point G,; Bamako, Mali.; A study was conducted between 1993 and 1996 in Bamako to determine the rate of occurrence of microsporidia in 88 patients. Most (80%) had chronic diarrhea associated with weight loss and 87.5% were HIV-positive. Intestinal microsporidia were detected in 32% of the patients infected with HIV-1, HIV-2, or coinfected wit
Successful treatment of cutaneous Kaposi's sarcoma by the 585-nm pulsed dye laser.: Dermatol Surg. 1997 Oct;23(10):973-5. Unique Identifier : AIDSLINE MED/98020380; Marchell N; Alster TS; Washington Institute of Dermatologic Laser Surgery, DC, USA.; The clinical appearance of Kaposi s sarcoma (KS) can cause significant disfigurement and lead to functional impairment, particularly if the lesions ulcerate and become secondarily infected. We describe a patient with a KS plaque on the face that was successfully treated with 585-nm pulsed dye laser (PDL) therapy. No r
Histopathologic findings in the lymphoid and reticuloendothelial system in pediatric HIV infection: a postmortem study.: Pediatr Pathol Lab Med. 1997 Nov-Dec;17(6):845-56. Unique Identifier : AIDSLINE MED/98015267; Quijano G; Siminovich M; Drut R; Servicio de Patologia, Hospital de Ninos Superiora Sor Maria; Ludovica, La Plata, Argentina.; The present report describes the histopathological features of lymphoreticular tissues in 29 pediatric autopsies of human immunodeficiency virus (HIV)-infected patients. Mean age for the whole group was 1.77 years; 68.9% and 62% of the cases were 2 years old or less and 1 year old or less at the time of death, respect
Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues.: Bioorg Med Chem. 1997 Aug;5(8):1715-23. Unique Identifier : AIDSLINE MED/97459097; Chen DF; Zhang SX; Xie L; Xie JX; Chen K; Kashiwada Y; Zhou BN; Wang P; Cosentino LM; Lee KH; Department of Pharmacognosy, Shanghai Medical University,; People's Republic of China.; Bioactivity-directed fractionation of an ethanolic extract of the stems of Kadsura interior led to the isolation and identification of 12 known lignans (1-12). Seven of these compounds (1, 6, 8-12) were active as anti-HIV agents. Gomisin-G (11) exhibited the most potent anti-HIV activity with EC50 and therapeutic inde
Viruses and apoptosis.: Br Med Bull. 1997;53(3):509-21. Unique Identifier : AIDSLINE MED/98041412; Young LS; Dawson CW; Eliopoulos AG; CRC Institute for Cancer Studies, University of Birmingham; Medical School, UK.; Virus infection and replication are often associated with apoptosis and this effect is likely to be responsible for much of the pathology associated with infectious disease. Many viruses encode proteins which can inhibit apoptosis thereby either prolonging the survival of infected cells such that the production of pro
AIDS and the death receptors.: Br Med Bull. 1997;53(3):604-16. Unique Identifier : AIDSLINE MED/98041418; Peter ME; Ehret A; Berndt C; Krammer PH; Tumorimmunology Program, German Cancer Research Center,; Heidelberg, Germany.; Activation-induced cell death (AICD) of T cells involves the CD95 receptor/ligand system. T cell activation through the T cell receptor results in expression of the CD95 ligand (CD95L) that acts on CD95+ cells by direct binding and in a paracrine or autocrine fashion. In AIDS, upregulation of CD95L in T cells is accel
A model for analysis of the nurse-patient interactive process (MAIP).: J Psychiatr Ment Health Nurs. 1997 Aug;4(4):303-6. Unique Identifier : AIDSLINE MED/98029120; Moreira AS; Rodrigues AR; Coler MS; Department of Public Health and Psychiatric Nursing, Federal; University of Paraiba, Brazil.; A model for analysis of the nurse-patient interactive process (MAIP), based on the analysis of the content of that interaction, is proposed as a method for determining appropriate psychosocial nursing diagnoses for the patient. The model focuses on the qualitative aspects of the phenomenon of interaction. The MAIP per
Ethical issues experienced by HIV-infected African-American women.: Nurs Ethics. 1997 Sep;4(5):394-402. Unique Identifier : AIDSLINE MED/98009609; Smith KV; Russell J; University of Missouri-Kansas City, School of Nursing 64108-2676,; USA.; The epidemic of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) has led to many ethical problems. Most studies have focused on the ethical issues faced by nurses who provide care to persons with AIDS (PWA), rather than the ethical issues faced by PWAs themselves. The purpose of this st
Mortality experience of a young petrochemical industry cohort. 1979-1992 follow-up study of US-based employees.: J Occup Environ Med. 1997 Oct;39(10):970-82. Unique Identifier : AIDSLINE MED/98003662; Huebner WW; Schnatter AR; Nicolich MJ; Jorgensen G; Exxon Biomedical Sciences, Inc., East Millstone NJ 08875-2350,; USA.; This retrospective study examines the mortality patterns of a relatively young cohort of 81,746 former and current petrochemical company employees. Standardized mortality ratios (SMR) for 1979 through 1992 are generally from about unity to well below unity for major causes and numerous specific causes of death studied
Itraconazole maintenance treatment for histoplasmosis in AIDS: a prospective, multicenter trial.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):100-7. Unique Identifier : AIDSLINE MED/98019136; Hecht FM; Wheat J; Korzun AH; Hafner R; Skahan KJ; Larsen R; Limjoco MT; Simpson M; Schneider D; Keefer MC; Clark R; Lai KK; Jacobson JM; Squires K; Bartlett JA; Powderly W; Albert Einstein College, Bronx, New York, U.S.A.; PURPOSE: To study the efficacy and safety of maintenance treatment with itraconazole for disseminated histoplasmosis in patients with AIDS. PATIENTS AND METHODS: This was a prospective, multicenter, open-label study conducted at university-based hospitals participating in the AIDS Clinical Trial Group (ACTG). Forty-si
Assessment of the changing willingness to participate in phase III HIV vaccine trials among men who have sex with men.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):108-15. Unique Identifier : AIDSLINE MED/98019137; Bartholow BN; MacQueen KM; Douglas JM Jr; Buchbinder S; McKirnan D; Judson FN; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, U.S. Department of Health and; Human Services, Atlanta, Georgia 30333, U.S.A. bnb1@cdc.gov; This paper describes the willingness of 1267 men who have sex with men (MSM) enrolled in a prospective HIV vaccine preparedness study from Chicago, Denver, and San Francisco to enroll in HIV vaccine efficacy trials. Respondents were interviewed at baseline and followed-up at 6, 12, and 18 months. At each visit respond
Estimating the number of AIDS-defining opportunistic illness diagnoses from data collected under the 1993 AIDS surveillance definition.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):116-21. Unique Identifier : AIDSLINE MED/98019138; Karon JM; Green TA; Hanson DL; Ward JW; National Center for HIV, STD, and TB Prevention-Surveillance and; Epidemiology, Centers for Disease Control and Prevention, United; States Department of Health and Human Services, Atlanta, Georgia; 30333, U.S.A.; Expansion of the surveillance definition for AIDS in the United States in 1993 caused a substantial distortion in the trend in AIDS incidence, mainly because CD4-positive (CD4+) T-lymphocyte criteria were added to the definition. To evaluate trends in the rate at which HIV-infected per
Redefining the growth of the heterosexual HIV/AIDS epidemic in Chicago.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):122-6. Unique Identifier : AIDSLINE MED/98019139; Murphy JT; Mueller GE; Whitman S; Epidemiology Program, Chicago Department of Public Health,; Illinois 60604, U.S.A.; A dramatic shift in the relative distribution of the five categories of heterosexual transmission for AIDS cases diagnosed in Chicago since 1991 prompted a mode-of-transmission validation study of what had become the most frequently reported heterosexual exposure: heterosexual relations with a person with AIDS (PWA) o
Strategies for universalistic and targeted HIV prevention.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):127-36. Unique Identifier : AIDSLINE MED/98019140; Des Jarlais DC; Padian N; Beth Israel Medical Center, New York, New York 10003, U.S.A.; The controversy over targeted versus universalistic programs for HIV prevention has persisted throughout the history of the HIV/AIDS epidemic in the United States and in some European countries. Building on previous analyses, we outline methods for integrating universalistic and ta
Effect of natural HIV-1 envelope V1-V2 sequence diversity on the binding of V3-specific and non-V3-specific antibodies.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):69-73. Unique Identifier : AIDSLINE GENBANK/U76696; Rencher SD; Hurwitz JL; Department of Immunology, St. Jude Children's Research Hospital,; University of Memphis, Tennessee, U.S.A.; In past years, much attention has been paid to the HIV-1 envelope (env) protein variable region 3 (V3), termed the principal neutralizing determinant. HIV-1 vaccines were often designed to target V3, and vaccine efficacy was often measured with V3-based assays. Thus, some disappointment resulted when volunteers in fir
Rapid and selective depletion of CD4+ T lymphocytes and preferential loss of memory cells on interaction of mononuclear cells with HIV-1 glycoprotein-expressing cells.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):74-82. Unique Identifier : AIDSLINE MED/98019133; Heinkelein M; Muller M; Kutsch O; Sopper S; Jassoy C; Institute for Virology and Immunobiology, Julius-Maximilians; University, Wurzburg, Germany.; Contact of HIV glycoprotein-expressing cells with CD4+ T lymphocytes in vitro causes cell-cell fusion and/or cytopathogenicity. The question of whether this process similarly underlies the death of helper T cells in vivo has not yet been resolved. To investigate the loss of uninfected CD4+ T cells in an environment th
Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):83-92. Unique Identifier : AIDSLINE MED/98019134; Liu Z; Cumberland WG; Hultin LE; Prince HE; Detels R; Giorgi JV; Department of Epidemiology, Los Angeles Center Multicenter AIDS; Cohort Study, UCLA School of Public Health, California, U.S.A.; The prognostic value of several immunologic markers were compared in Los Angeles Multicenter AIDS Cohort Study (MACS) participants, most of whom had been infected with HIV for >8 years. Markers studied included CD4+ cell number, flow cytometric measurements of CD8+ cell expression of CD38 and HLA-DR antigens, and seru
Prognostic value of serum HIV-RNA levels at virologic steady state after seroconversion: relation to CD4 cell count and clinical course of primary infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Oct 1;16(2):93-9. Unique Identifier : AIDSLINE MED/98019135; Pedersen C; Katzenstein T; Nielsen C; Lundgren JD; Gerstoft J; Department of Infectious Diseases, Odense University Hospital,; Denmark.; The objectives of this study were to evaluate the prognostic value of a single serum HIV-RNA measurement 6-24 months after HIV seroconversion, and to investigate whether any differences in outcome related to the clinical course of primary infection could be explained by presumed steady-state HIV-RNA levels at 6-24 mon
Enhancement of natural killer and antibody-dependent cytolytic activities of the peripheral blood mononuclear cells of HIV-infected patients by recombinant IL-15.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Nov 1;16(3):137-45. Unique Identifier : AIDSLINE MED/98050930; Loubeau M; Ahmad A; Toma E; Menezes J; Department of Microbiology and Immunology, University of Montreal; and Ste-Justine Hospital, Quebec, Canada.; Natural killer (NK) cells are an important subset of lymphocytes capable of killing virus-infected target cells without prior sensitization. HIV-infected individuals show impairment of their NK cell activity. Although the mechanism responsible for this defect remains unclear, NK cytotoxicity of lymphocytes from these
HIV-1 proviral DNA load across neuroanatomic regions of individuals with evidence for HIV-1-associated dementia.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Nov 1;16(3):146-52. Unique Identifier : AIDSLINE MED/98050931; Fujimura RK; Goodkin K; Petito CK; Douyon R; Feaster DJ; Concha M; Shapshak P; Department of Psychiatry, University of Miami School of Medicine,; Florida 33136, U.S.A.; A definitive relation between HIV-1 load and the clinical diagnosis of HIV-1-associated dementia (HAD) has not yet been established. Knowledge of the neuroanatomic distribution of HIV-1 load in the brain of individuals with HAD and HIV-1 encephalitis may facilitate elucidation of t
Regional differences in use of antiretroviral agents and primary prophylaxis in 3122 European HIV-infected patients. EuroSIDA Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Nov 1;16(3):153-60. Unique Identifier : AIDSLINE MED/98050932; Lundgren JD; Phillips AN; Vella S; Katlama C; Ledergerber B; Johnson AM; Reiss P; Gatell J; Clumeck N; Dietrich M; Benfield TL; Nielsen JO; Pedersen C; University of Copenhagen, Hvidovre Hospital, Denmark.; EuroSIDA@inet.uni-c.dk; Little is known about how widely HIV-related drugs are used outside controlled clinical trials. We ther