Prevalence of congenital CMV in children born to HIV-infected women. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Prevalence of congenital CMV in children born to HIV-infected women.

Int Conf AIDS. 1998;12:43 (abstract no. 12161). Unique Identifier : AIDSLINE ICA12/98386936
Lozano JS; Ramos Amador JT; Bodas A; Rodriguez-Cerrato V; Ruiz-Contreras J; Otero J; Hospital 12 de Octubre DPTO Pediatria CTRA de Andalucia Km.5,; Madrid, Spain.

Abstract: BACKGROUND: The rate of congenital cytomegalovirus (CMV) infection in infants born to HIV-infected women is unknown. OBJECTIVES: 1) To determine the rate of congenital transmission of CMV in perinatally HIV-exposed children and 2) to evaluate possible risk factors associated with congenital CMV infection in this population. PATIENTS AND METHODS: We prospectively studied the cohort of children born to HIV-infected women between 1987-1997. Newborn CMV urine cultures were scheduled at birth and serially thereafter. Congenital CMV infection was defined as a positive CMV culture obtained during the first 3 weeks of life. We only analyzed the cohort of children born at our hospital followed from birth. RESULTS: Ten children out of 156 born to HIV-infected mothers had a congenital CMV infection (transmission rate 6.4%, CI 95: 3.3-11.1%). CD4 cell counts and viral load were not different between transmitting and nontransmitting mothers. We found a significant association between duration of rupture of obstetric membranes and both CMV-infection and HIV-infection. Overall 21 children (13.5%) became HIV-infected. Five (23.8%) of these 21 children were diagnosed with congenital CMV infection, whereas only 5 (3.7%) of 135 children who seroreverted had a congenital CMV infection (p = 0.005; Fisher exact test) CONCLUSIONS: The prevalence of congenital CMV infection in children born to HIV-infected women between 1987-1997 in our hospital was 6.4%, higher than the prevalence in the general population in our setting. Univariate analysis showed an association between perinatal transmission of HIV and CMV. Whether CMV is an independent risk factor for HIV-transmission or not remains to be elucidated.
Keywords: MEETING ABSTRACTS AIDS-Related Opportunistic Infections/CONGENITAL/*EPIDEMIOLOGY/ TRANSMISSION Cohort Studies Cytomegalovirus Infections/CONGENITAL/*EPIDEMIOLOGY/TRANSMISSION *Disease Transmission, Vertical Female Human Infant, Newborn Pregnancy Prevalence Prospective Studies Risk Factors Spain/EPIDEMIOLOGYKWDmeetingabstractsaids-relatedopportunisticinfections/congenital/KWDepidemiology/transmissioncohortstudiescytomegalovirusinfections/congenital/KWDepidemiology/transmissionKWDdiseasetransmission,verticalfemalehumaninfant,newbornpregnancyprevalenceprospectivestudiesriskfactorsspain/epidemiology
981230
M98C6167

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