How the MHC selects Th1/Th2 immunity. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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How the MHC selects Th1/Th2 immunity.

Immunol Today. 1998 Apr;19(4):157-63. Unique Identifier : AIDSLINE MED/98237948
Murray JS; Dept of Microbiology, University of Kansas, Lawrence 66045, USA.

Abstract: While the effects of cytokines on T helper 1 (Th1)/Th2 differentiation are well documented, it is less clear why a dichotomy of effector cytokine production would initiate from antigen-specific lymphocytes. Nevertheless, in defined experimental systems, the interaction between T-cell receptor TCR), peptide and major histocompatibility complex (MHC) can determine Th1/Th2 dominance. Here, Joseph Murray discusses how TCR affinity and ligand density might interface with innate forces in the selection of CD4+ T-cell functions.
Keywords: *Immunity, Cellular/IMMUNOLOGY *Major Histocompatibility Complex/IMMUNOLOGY *Th1 Cells/IMMUNOLOGY *Th2 Cells/IMMUNOLOGYKWDimmunity,cellular/immunologyKWDmajorhistocompatibilitycomplex/immunologyKWDth1cells/immunologyKWDth2cells/immunology
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Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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