HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine.

Biotechnol Appl Biochem. 1998 Apr;27 ( Pt 2):89-95. Unique Identifier : AIDSLINE MED/98231061
Jelonek MT; Maskrey JL; Cummins LM; Arora Y; Steimer KS; White-Scharf M; Keller MA; Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical; Center, Torrance 90509, USA.

Abstract: The murine model was developed to assess the effects of maternally transferred HIV hyperimmune globulin or human intravenous immune globulin on the immunization of the offspring at 18-21 days of age with rgp 120SF2-complete Freund's adjuvant. Either HIV hyperimmune globulin or intravenous immune globulin was administered intraperitoneally to post-partum BALB/c mice and was transferred via milk to the offspring. Both HIV hyperimmune globulin and intravenous immune globulin inhibited the offspring anti-rgp 120SF2 IgG response to the vaccine. The HIV hyperimmune globulin inhibition persisted for 28 days after immunization while the intravenous immune globulin inhibition was still present at 63 days after immunization. In addition, the intravenous immune globulin had a more generalized immunosuppressive effect, inhibiting the IgG response to both rpg 120SF2 and an additional protein antigen, hen egg-white lysozyme. Effects of maternal or exogenously administered pre-existing antibody, including control antibodies (intravenous immune globulin), on the newborn response to HIV and other vaccines must be carefully evaluated when vaccine studies proceed in newborns.
Keywords: *AIDS Vaccines/PHARMACOLOGY *HIV Antibodies/PHARMACOLOGY *Immunity, Maternally-Acquired/DRUG EFFECTS *Immunoglobulins, Intravenous/PHARMACOLOGYKWDaidsvaccines/pharmacologyKWDhivantibodies/pharmacologyKWDimmunity,maternally-acquired/drugeffectsKWDimmunoglobulins,intravenous/pharmacology
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