B cells inhibit induction of T cell-dependent tumor immunity.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

B cells inhibit induction of T cell-dependent tumor immunity.

Nat Med. 1998 May;4(5):627-30. Unique Identifier : AIDSLINE MED/98244640
Qin Z; Richter G; Schuler T; Ibe S; Cao X; Blankenstein T; Max-Delbruck-Center for Molecular Medicine, Berlin, FRG.

Abstract: Cytotoxic T lymphocyte (CTL) mediated tumor immunity against major histocompatibility antigen (MHC) class I-positive but class II-negative tumors often requires help from CD4+ T cells. These CD4 cells are activated by MHC class II-positive cells that present tumor derived antigens. Considering that different antigen presenting cells, such as B cells, macrophages and dendritic cells compete for antigen and influence the outcome of an immune response, we analyzed tumor immunity in B cell-deficient mice. These mice appear normal with regard to T cell immunity and tolerance to some pure foreign antigens. We show here that the low immunogenicity of tumors is caused by B cells whose presence in the priming phase results in disabled CD4+ T cell help for CTL mediated tumor immunity. Instead, in the presence of B cells, a non-protective humoral immune response is induced. Our results may explain the enigmatic observation that tumor-reactive antibodies occur frequently in cancer patients.

Keywords: *Adenocarcinoma/IMMUNOLOGY *B-Lymphocytes/IMMUNOLOGY *Mammary Neoplasms, Experimental/IMMUNOLOGY *T-Lymphocytes/IMMUNOLOGY
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