Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella.

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella.

Chem Pharm Bull (Tokyo). 1998 Apr;46(4):684-6. Unique Identifier : AIDSLINE MED/98240207
Ohta K; Mizushina Y; Hirata N; Takemura M; Sugawara F; Matsukage A; Yoshida S; Sakaguchi K; Department of Applied Biological Science, Faculty of Science and; Technology, Science University of Tokyo, Japan.

Abstract: A new sulfolipid, KM043, which belongs to the 6-sulfo-alpha-D-quinovopyranosyl-(1-->3')-1',2'-diacylglycerol SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as a potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1. Its structure was determined on the basis of spectroscopic and gas chromatographic analyses. The inhibition was dose-dependent, and complete (more than 90%) inhibition of DNA polymerase alpha (pol. alpha), DNA polymerase beta (pol. beta) and HIV-reverse transcriptase type 1 (HIV-RT) was observed at concentrations of 5, 10, and 30 microM, respectively.

Keywords: *Algae, Red/CHEMISTRY *DNA-Directed DNA Polymerase/ANTAGONISTS & INHIB *Glycolipids/ISOLATION & PURIF *HIV-1 Reverse Transcriptase/ANTAGONISTS & INHIB *Reverse Transcriptase Inhibitors/ISOLATION & PURIF
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M9881142

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