Somatic hypermutation of the T cell receptor V beta gene in microdissected splenic white pulps from HIV-1-positive patients. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Somatic hypermutation of the T cell receptor V beta gene in microdissected splenic white pulps from HIV-1-positive patients.

Eur J Immunol. 1998 May;28(5):1604-10. Unique Identifier : AIDSLINE MED/98264629
Cheynier R; Henrichwark S; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris, France.

Abstract: Somatic mutation of rearranged immunoglobulin V genes occurs in germinal centers (GC), resulting in affinity maturation of the immune response. Rearranged T cell receptor (TCR) genes were thought to be excluded from this process despite similarities in their gene structure. Somatic mutations were found among TCR V alpha (TCRAV) chains of antigen-specific T cells localized in GC of mice. Here, somatically mutated TCR V beta 3 (TCRBV) chains are identified among microdissected splenic white pulps from HIV-positive individuals. Both the frequency and the nature of the base substitutions were found to be similar to those of mutated immunoglobulin VH genes. This was true for intrinsic mutations in the TCR framework regions as well as for mutations underlying selective pressures in the TCRBV5 gene segment. The concentration of mutations and a preference for replacement mutations in complementarity determining regions of expanded clones were indicative of a positive selection process.
Keywords: *Dissection *HIV Seropositivity/IMMUNOLOGY *Mutation/IMMUNOLOGY *Receptors, Antigen, T-Cell, alpha-beta/GENETICS *Spleen/METABOLISMKWDdissectionKWDhivseropositivity/immunologyKWDmutation/immunologyKWDreceptors,antigen,t-cell,alpha-beta/geneticsKWDspleen/metabolism
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Copyright © 1998 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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