Genomic organization and promoter characterization of human CXCR4 gene. NLM AIDSLINE Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

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Genomic organization and promoter characterization of human CXCR4 gene.

FEBS Lett. 1998 Apr 17;426(2):271-8. Unique Identifier : AIDSLINE MED/98258970
Caruz A; Samsom M; Alonso JM; Alcami J; Baleux F; Virelizier JL; Parmentier M; Arenzana-Seisdedos F; Unite d'Immunologie Virale, Institut Pasteur, Paris, France.

Abstract: CXCR4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. Recently, CXCR4 has drawn unexpected attention as it was recently identified as a co-factor required for entry of lymphotropic HIV isolates in CD4+ T lymphocytes. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. To investigate the mechanisms controlling both the constitutive and induced expression of CXCR4 receptors we have isolated and characterized the promoter region and determined the genomic structure of the human gene. The CXCR4 gene contains two exons separated by an intronic sequence. A 2.6 kb 5'-flanking region located upstream the CXCR4 open reading frame contains a TATA box and the transcription start site characteristic of a functional promoter. This region also contains putative consensus binding sequences for different transcription factors, some of them associated with the hemopoiesis and lymphocyte development.
Keywords: *Receptors, CXCR4/GENETICSKWDreceptors,cxcr4/genetics
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