1998

Foreign peptides expressed in engineered chimeric self molecules.: Biotechnol Genet Eng Rev. 1998;15:159-98. Unique Identifier : AIDSLINE MED/98234691; Casares S; Bot A; Brumeanu TD; Bona CA; Department of Microbiology, Mount Sinai School of Medicine, New York,; NY 10029, USA.
How the MHC selects Th1/Th2 immunity.: Immunol Today. 1998 Apr;19(4):157-63. Unique Identifier : AIDSLINE MED/98237948; Murray JS; Dept of Microbiology, University of Kansas, Lawrence 66045, USA.; While the effects of cytokines on T helper 1 (Th1)/Th2 differentiation are well documented, it is less clear why a dichotomy of effector cytokine production would initiate from antigen-specific lymphocytes. Nevertheless, in defined experimental systems, the interaction between T-cell receptor TCR), peptide and major h
HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine.: Biotechnol Appl Biochem. 1998 Apr;27 ( Pt 2):89-95. Unique Identifier : AIDSLINE MED/98231061; Jelonek MT; Maskrey JL; Cummins LM; Arora Y; Steimer KS; White-Scharf M; Keller MA; Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical; Center, Torrance 90509, USA.; The murine model was developed to assess the effects of maternally transferred HIV hyperimmune globulin or human intravenous immune globulin on the immunization of the offspring at 18-21 days of age with rgp 120SF2-complete Freund s adjuvant. Either HIV hyperimmune globulin or intravenous immune globulin was administe
The athlete: an immunocompromised host.: Adv Pediatr Infect Dis. 1997;13:79-99. Unique Identifier : AIDSLINE MED/98205952; Hughes WT; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee, USA.
Three-dimensional structure of HIV-1 Rev protein filaments.: J Struct Biol. 1998 Jan;121(1):41-52. Unique Identifier : AIDSLINE MED/98234702; Watts NR; Misra M; Wingfield PT; Stahl SJ; Cheng N; Trus BL; Steven AC; Williams RW; Laboratory of Structural Biology Research, National Institute of; Arthritis and Musculoskeletal and Skin Diseases, National Institutes; of Health, Bethesda, Maryland 20892, USA.; The HIV-1 Rev protein facilitates the export of incompletely spliced and unspliced viral mRNAs from the nucleus. Rev polymerizes into two types of filaments in vitro. In the presence of RNA, Rev forms poorly ordered structures, while in the absence of RNA it polymerizes into regular hollow filaments. We have determine
Relapse prevention as an interventive model for HIV risk reduction in gay and bisexual men.: AIDS Educ Prev. 1998 Feb;10(1):1-18. Unique Identifier : AIDSLINE MED/98165993; Roffman RA; Stephen RS; Curtin L; Gordon JR; Craver JN; Stern M; Beadnell B; Downey L; School of Social Work, University of Washington, Seattle 98105-6299,; USA.; Despite considerable self-initiated HIV risk reduction among men who have sex with men, little is known about how to design interventions that will effectively assist individuals from this population in maintaining safer sex behaviors over time. The present study evaluated the effectiveness of a 17-session group couns
Effectiveness of an HIV risk reduction counseling intervention for out-of-treatment drug users.: AIDS Educ Prev. 1998 Feb;10(1):19-33. Unique Identifier : AIDSLINE MED/98165994; Kotranski L; Semaan S; Collier K; Lauby J; Halbert J; Feighan K; Division of Research and Evaluation, Philadelphia Health Management; Corporation, PA 19102-5085, USA.; This study examined and compared the effectiveness of two counseling interventions designed to reduce the HIV drug and sexual risk behaviors of 684 out-of-treatment drug users recruited from South Philadelphia, PA. All study participants received a standard intervention and one half were randomly assigned to also rece
Factors related to condom use among four groups of female sex workers in Bali, Indonesia.: AIDS Educ Prev. 1998 Feb;10(1):34-45. Unique Identifier : AIDSLINE MED/98165995; Ford K; Wirawan DN; Fajans P; Department of Epidemiology, School of Public Health, University of; Michigan, Ann Harbor 48109-2029, USA. kford@sph.umich.edu; This article tests a behavioral model of condom use for four groups of female commercial sex workers. Data were drawn from a study of 614 female sex workers conducted in Bali, Indonesia . AIDS knowledge, risk behaviors, and factors related to condom use varied substantially among
Cultural feasibility studies in preparation for clinical trials to reduce maternal-infant HIV transmission in Haiti.: AIDS Educ Prev. 1998 Feb;10(1):46-62. Unique Identifier : AIDSLINE MED/98165996; Coreil J; Losikoff P; Pincu R; Mayard G; Ruff AJ; Hausler HP; Desormeau J; Davis H; Boulos R; Halsey NA; College of Public Health, University of South Florida, Tampa 33612,; USA.; A cultural feasibility study is defined as one that investigates scientific as well as ethical, behavioral, and social issues in the design of clinical trials. The value of such a broadly defined assessment is illustrated through the presentation of two case studies conducted to prepare for clinical trials to reduce m
Sources of information for HIV prevention program managers: a national survey.: AIDS Educ Prev. 1998 Feb;10(1):63-74. Unique Identifier : AIDSLINE MED/98165997; Goldstein E; Wrubel J; Faigeles B; DeCarlo P; Center for AIDS Prevention Studies (CAPS), San Francisco, CA 94105,; USA.; This study s objective was to find out if HIV prevention program planners seek out science in designing interventions, and if not, where they turn for prevention information. Researchers conducted a survey of 284 program managers of AIDS prevention programs across the United States . Rey
Assessing the construct validity of the AIDS Attitude Scale.: AIDS Educ Prev. 1998 Feb;10(1):75-89. Unique Identifier : AIDSLINE MED/98165998; Bruce KE; Reid BC; Department of Psychology, University of North Carolina at Wilmington; 28403, USA. bruce@uncwil.edu; To assess the construct validity of the AIDS Attitude Scale (AAS) Shrum, Turner, & Bruce, 1989), we administered it and related attitude scales to introductory psychology students (n = 279) and gay/lesbian support group members (n = 38). A subset of the students (n = 105) participated in a concurrent validity study
Reproductive decisions of women at risk for acquiring HIV infection.: AIDS Educ Prev. 1998 Feb;10(1):90-7. Unique Identifier : AIDSLINE MED/98165999; Ahluwalia IB; DeVellis RF; Thomas JC; Department of Health Behavior and Health Education, University of; North Carolina at Chapel Hill, USA.; Approximately 1 to 1.5 million people in the United States are infected with HIV. The incidence of HIV is increasing among women and children. Little information exists regarding the determinants of reproductive decisions of women at risk of HIV infection. This study investigated the c
Th2-like cytokine activity in dermatitis herpetiformis.: Br J Dermatol. 1998 Feb;138(2):242-7. Unique Identifier : AIDSLINE MED/98265578; Caproni M; Feliciani C; Fuligni A; Salvatore E; Atani L; Bianchi B; Pour SM; Proietto G; Toto P; Coscione G; Amerio P; Fabbri P; Department of Dermatology, University of Florence, Italy.; Dermatitis herpetiformis (DH) is a chronic subepidermal blistering disease, in which a perivascular cellular infiltrate, composed mainly of CD4+ T lymphocytes together with a varying number of neutrophils and eosinophils, is thought to be important in the pathogenesis of blister formation. The aim of this study was to
An indolent penile herpetic ulcer in a patient with previously undiagnosed human immunodeficiency virus infection.: Br J Dermatol. 1998 Feb;138(2):334-6. Unique Identifier : AIDSLINE MED/98265596; Tayal SC; Pattman RS; Mclelland J; Sviland L; Snow MH; Department of Genito-Urinary Medicine, Newcastle General Hospital,; Newcastle Upon Tyne, U.K.; We report a case of an atypical penile herpetic ulcer in a man with previously undiagnosed human immunodeficiency virus (HIV) infection. Swabs of the lesion were negative for herpes simplex virus (HSV) by culture and electron microscopy. However, histopathology of biopsy material showed characteristic herpetic multinu
Streptococcal impetigo induces Th1-preponderant activation of T lymphocytes with subsequent anergy to superantigenic exotoxins in patients with atopic dermatitis [letter]: Br J Dermatol. 1998 Feb;138(2):357-8. Unique Identifier : AIDSLINE MED/98265602; Tokura Y; Ishii-Ginoza M; Seo N; Ito T; Sakurai M; Furukawa F; Takigawa M
Unusual skin ulceration in an HIV-positive patient who had cutaneous syphilis and neurosyphilis [letter]: Br J Dermatol. 1998 Feb;138(2):366-7. Unique Identifier : AIDSLINE MED/98265610; Ajithkumar K
Increased presence of Epstein-Barr virus DNA in ocular fluid samples from HIV negative immunocompromised patients with uveitis.: Br J Ophthalmol. 1998 Mar;82(3):245-51. Unique Identifier : AIDSLINE MED/98265330; Ongkosuwito JV; Van der Lelij A; Bruinenberg M; Wienesen-van Doorn M; Feron EJ; Hoyng CB; de Keizer RJ; Klok AM; Kijlstra A; Department of Ophthalmology, Academic Medical Centre, University of; Amsterdam, Netherlands.; AIMS: To investigate whether routine testing for Epstein-Barr virus (EBV) is necessary in the examination of a patient with uveitis. METHODS: Intraocular EBV DNA was determined in 183 ocular fluid samples taken from patients with AIDS and uveitis, HIV negative immunocompromised uveitis, acute retinal necrosis, toxopla
Sustained release intravitreal ganciclovir implant as salvage treatment in AIDS related cytomegalovirus retinitis [letter]: Br J Ophthalmol. 1998 Mar;82(3):333. Unique Identifier : AIDSLINE MED/98265353; Kamal A; King A; Sylvestri G; Dhillon B
Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex.: Biochemistry. 1998 May 12;37(19):6667-78. Unique Identifier : AIDSLINE MED/98244844; Heuer TS; Brown PO; Department of Biochemistry, Program in Cancer Biology, Stanford; University Medical Center, California 94305-5428, USA.; The virally encoded integrase protein carries out retroviral integration, which requires specific interactions with the two ends of the viral DNA, and also with host DNA that is the target of integration. We attached a photo-cross-linking agent to specific viral and target DNA sites to identify regions of the integras
[The usefulness of abdominal echography in the diagnosis of extrapulmonary tuberculosis in patients with HIV infection]: Enferm Infecc Microbiol Clin. 1998 Feb;16(2):61-5. Unique Identifier : AIDSLINE MED/98247508; Dominguez-Castellano A; Yanez P; Muniain MA; Balonga B; Rios MJ; Rodriguez-Bano J; Bueno C; Perez-Cano R; Servicio de Medicina Interna, Hospital Universitario Virgen; Macarena-San Lazaro, Sevilla. adomin@cica.es; BACKGROUND: The aim of the present study was to analyze the diagnostic profitability of echography as an indicator of extrapulmonary tuberculosis in patients with HIV infection. PATIENTS AND METHODS: HIV positive patients presenting fever of long duration were prospectively studied with an active search for specific e
Inhibition of human immunodeficiency virus type 1 replication by nuclear chimeric anti-HIV ribozymes in a human T lymphoblastoid cell line.: Hum Gene Ther. 1998 Mar 20;9(5):621-8. Unique Identifier : AIDSLINE MED/98211332; Michienzi A; Conti L; Varano B; Prislei S; Gessani S; Bozzoni I; Istituto Pasteur, Fondazione Cenci-Bolognetti, Department of Genetics; and Molecular Biology, University La Sapienza, Rome, Italy.; Human immunodeficiency virus (HIV) infection represents one of the most challenging systems for gene therapy. Thanks to the extended knowledge of the molecular biology of the HIV life cycle, many different strategies have been developed including transdominant modifications of HIV proteins, RNA decoys, antisense RNA,
Eight-year observation and comparative study of specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) subtypes A and B: terminal acquired immunodeficiency syndrome in a cat infected with FIV petaluma strain.: J Vet Med Sci. 1998 Mar;60(3):315-21. Unique Identifier : AIDSLINE MED/98221550; Kohmoto M; Uetsuka K; Ikeda Y; Inoshima Y; Shimojima M; Sato E; Inada G; Toyosaki T; Miyazawa T; Doi K; Mikami T; Department of Veterinary Microbiology, Graduate School of Agriculture; and Life Sciences, University of Tokyo.; Three specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) strains Petaluma, TM1 and TM2, respectively were observed for over 8 years. Without showing any significant clinical signs of immunodeficiency syndrome AIDS) for 8 years and 4 months of asymptomatic phase, the Petaluma-i
Rapid and progressive CD4+ decline in a monkey infected with an SIV+HIV-1 chimeric virus.: J Vet Med Sci. 1998 Mar;60(3):361-3. Unique Identifier : AIDSLINE MED/98221558; Nagamachi D; Igarashi T; Shimada T; Kuwata T; Ui M; Ami Y; Enose Y; Ido E; Fukumoto M; Hayami M; Department of Pathology and Tumor Biology, Graduate School of; Medicine, Kyoto, Japan.; We previously constructed a simian immunodeficiency virus+human immunodeficiency virus type 1 (HIV-1) chimeric virus, NM-3rN to generate a pathogenic HIV-1 in macaque monkeys. During the in vivo passage of this virus in several monkeys, a viral strain, R43-56 was obtained which acquired a better replication ability in
Immunoregulatory activity in adult rat testicular interstitial fluid: relationship with intratesticular CD8+ lymphocytes following treatment with ethane dimethane sulfonate and testosterone implants.: Biol Reprod. 1998 Apr;58(4):935-42. Unique Identifier : AIDSLINE MED/98206800; Hedger MP; Wang J; Lan HY; Atkins RC; Wreford NG; Institute of Reproduction and Development, Monash University, Clayton,; Victoria, Australia. mark.hedger@med.monash.edu.au; Regulation of T-cell traffic and function in the adult rat testis was assessed following treatment with the specific Leydig cell cytoxin, ethane dimethane sulfonate (EDS), and s.c. testosterone implants to prevent Leydig cell recovery. The distribution of T-cell subsets in the testis was determined immunohistochemical
Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor beta on lymphocyte subsets in vitro.: Biol Reprod. 1998 Apr;58(4):943-51. Unique Identifier : AIDSLINE MED/98206801; Tompkins AB; Hutchinson P; de Kretser DM; Hedger MP; Institute of Reproduction and Development, Monash University, Clayton,; Victoria, Australia.; The rat testis is considered to be an immunologically privileged site because of its reduced capacity to support antigen-specific immune responses. To understand this phenomenon, it is essential to characterize both the lymphocyte subpopulations normally present in the testis and their regulation by testicular cytokin
Accidental transmission of HCV and treatment with interferon.: J Gastroenterol Hepatol. 1998 Mar;13(3):238-43. Unique Identifier : AIDSLINE MED/98230159; Takagi H; Uehara M; Kakizaki S; Takahashi H; Takezawa J; Kabeya K; Satoh K; Kojima A; Saito S; Matsumoto T; Hashimoto Y; Abe T; Yamada T; Konaka K; Shimoda R; Takayama H; Takehara K; Nagamine T; Mori M; The First Department of Internal Medicine, Gunma University School of; Medicine, Maebashi, Japan. htakagi@sb.gunma-u.ac.jp; Accidental transmission of contagious pathogens, especially hepatitis C virus (HCV), by needlestick or other means as an occupational hazard for medical staff is of concern. We retrospectively analysed cases of work-related accidental injury with pathogens such as hepatitis B virus (HBV), HCV, syphilis and human immun
[Prevention of hepatitis B--analysis of cost-effectiveness after liver transplantation]: Langenbecks Arch Chir Suppl Kongressbd. 1997;114:1048-50. Unique Identifier : AIDSLINE MED/98235417; Golling M; Arnold JC; Rudek B; Theilmann L; Herfarth C; Otto G; Chirurgische und Medizinische Universitatsklinik Heidelberg.; HBV recurrence, despite immunoprophylaxis which occurred in 67% of our patients, remains the main problem following liver transplantation for HBV infection. Pretransplant viral replication (HBV-DNA) and probably viral mutation may account to some degree for the failures involved in hyperimmunoglobulin prophylaxis. In
Educational preparation of nurses to meet the needs of human immunodeficiency virus (HIV) infected patients.: Br J Theatre Nurs. 1998 Apr;8(1):21-7. Unique Identifier : AIDSLINE MED/98254751; Vials JM; School of Nursing and Midwifery, University of Wolverhampton.
Isoform-specific O-glycosylation by murine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, in vivo.: Glycobiology. 1998 Apr;8(4):367-71. Unique Identifier : AIDSLINE MED/98165749; Nehrke K; Hagen FK; Tabak LA; Department of Dental Research, School of Dentistry, University of; Rochester, Rochester, NY 14648, USA.; Multiple isoforms of UDP-GalNAc:polypeptide N-acetylgalactosaminyl- transferase (ppGaNTase) have been cloned and expressed from a variety of organisms. In general, these isoforms display different patterns of tissue-specific expression, but exhibit overlapping substrate specificities, in vitro . A peptide substrate, d
The effect of pair formation and variable infectivity on the spread of an infection without recovery.: Math Biosci. 1998 Feb;148(1):83-113. Unique Identifier : AIDSLINE MED/98260117; Kretzschmar M; Dietz K; Institut fur Medizinische Biometrie, Universitat Tubingen, Germany.; mirjam.kretzschmar@rivm.nl; For the spread of an infection without recovery we compare the properties of a model in which contacts are assumed to be instantaneous and every contact is with a new partner to a model with an explicit description of partnership formation and duration. We investigate the dynamic behaviour at the beginning of the epid
Recurrent central diabetes insipidus secondary to cryptococcal meningitis.: J Assoc Acad Minor Phys. 1998;9(1):22-4. Unique Identifier : AIDSLINE MED/98246763; Woredekal Y; Department of Medicine, Brooklyn Veterans Administration Medical; Center, New York, USA.; Meningitis is often associated with hyponatremia due to inappropriate secretion of antidiuretic hormone, and diabetes insipidus is associated with bacterial meningitis. This article describes a patient with acquired immunodeficiency syndrome who experienced recurrent episodes of central diabetes insipidus in associati
Oral hairy leukoplakia with ultrastructural evidence of Merkel-like cells in human tongue epithelium.: Bull Group Int Rech Sci Stomatol Odontol. 1998 Jan-Mar;40(1):24-37. Unique Identifier : AIDSLINE MED/98228858; Cobb M; MacNeill R; Tobin J; Department of Periodontics, School of Dentistry, University of; Missouri-Kansas City, USA. CobbC@smtpgate.umkc.edu; The purpose of this investigation was to examine cells in the stratum basale and subjacent lamina propria of oral hairy leukoplakia (OHL) specimens for previously unreported morphological changes. Tongue biopsy specimens were obtained from ten HIV-positive and five healthy male patients and examined by light (LM) and
An efficient and cost-effective isotope labeling protocol for proteins expressed in Escherichia coli.: J Biomol NMR. 1998 Jan;11(1):97-102. Unique Identifier : AIDSLINE MED/98227443; Cai M; Huang Y; Sakaguchi K; Clore GM; Gronenborn AM; Craigie R; Laboratory of Chemical Physics, National Institute of Diabetes and; Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, MD 20892-0520, USA.; A cost-effective protocol for uniform 15N and/or 13C isotope labeling of bacterially expressed proteins is presented. Unlike most standard protocols, cells are initially grown in a medium containing nutrients at natural abundance and isotopically labeled nutrients are only supplied at the later stages of growth and du
Pregnant women should routinely be offered HIV tests [news]: BMJ. 1998 May 2;316(7141):1333. Unique Identifier : AIDSLINE MED/98273459; Mayor S
Screening for human T cell leukaemia/lymphoma virus among blood donors in Sweden: cost effectiveness analysis.: BMJ. 1998 May 9;316(7142):1417-22. Unique Identifier : AIDSLINE MED/98239599; Tynell E; Andersson S; Lithander E; Arneborn M; Blomberg J; Hansson HB; Krook A; Nomberg M; Ramstedt K; Shanwell A; Bjorkman A; Division of Infectious Diseases, Karolinska Institutet, Danderyd; University Hospital, Danderyd, Sweden. elsa.tynell@inf.ds.sll.se; OBJECTIVE: To analyse the cost effectiveness of a national programme to screen blood donors for infection with the human T cell leukaemia/lymphoma virus. DESIGN: Three models for calculating the costs and benefits of screening were developed. The first model analysed the cost of continuously testing all donations; the
The epidemiology of cancer of the small bowel.: Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):243-51. Unique Identifier : AIDSLINE MED/98180738; Neugut AI; Jacobson JS; Suh S; Mukherjee R; Arber N; Department of Medicine, College of Physicians and Surgeons, Columbia; University, New York, New York 10032, USA.; Despite its anatomical location between two regions of high cancer risk, the small bowel rarely develops a malignant tumor. However, in recent years, small bowel cancer incidence rates have begun to rise. The purpose of this review is to explore the descriptive and analytic epidemiology of small bowel cancer for those
Categorical funding to seamless systems of care: the challenge for community-based primary care providers.: J Case Manag. 1997 Fall;6(3):96-103. Unique Identifier : AIDSLINE MED/98235052; Ulmer C; Lewis-Idema D; Falik M; Raggio TP; Stoessel P; Coughlin T; Butterworth D; Tillman J; MDS Associates, Wheaton, MD 20902, USA.; Integrating categorical funding to design seamless systems of care for individual patients is a challenge faced by many local community-based providers. Providers may choose to develop separate site-specific categorical programs for patients with human immunodeficiency virus (HIV) [e.g., specialized treatment site o
Rabies infection and specific effect of vaccination in mice selected for high and low immunobiological parameters.: Braz J Med Biol Res. 1997 Nov;30(11):1309-13. Unique Identifier : AIDSLINE MED/98193407; Queiroz-da-Silva LH; De-Franco M; Sant'Anna OA; Departamento de Apoio, Curso de Medicina Veterinaria, Universidade; Estadual Paulista, Aracatuba, SP, Brasil.; Innate and acquired resistance to rabies infection was investigated in mice genetically selected for high (H) or low (L) antibody responsiveness from selections I, III and IV and in mice selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction. These mouse lines were infected intramuscularly with
Serological level of ICAM and ELAM adhesion molecules in allergic vascularitis.: Rom J Intern Med. 1997 Jan-Dec;35(1-4):83-8. Unique Identifier : AIDSLINE MED/98223750; Alecu M; Coman G; Galatescu E; Dermatovenereology Center, Scarlat Longhin Clinical Hospital for; Dermatology, Bucharest, Romania.; A 24-patient lot with hypersensitivity vasculitis was investigated for serological determinations of ICAM and ELAM adhesion molecules. Determinations were made in attack and in remission. Over two thirds of the cases presented elevated serological levels of ICAM and ELAM in attack, with twofold higher values than norm
AIDS and HIV infection worldwide.: Commun Dis Rep CDR Wkly. 1997 May 23;7(21):189-90. Unique Identifier : AIDSLINE MED/98166358
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1998 Feb 27;8(9):84. Unique Identifier : AIDSLINE MED/98185084
Socioeconomic influences on the transmission of human immunodeficiency virus infection: the hidden risk.: Arch Fam Med. 1998 May-Jun;7(3):214-7. Unique Identifier : AIDSLINE MED/98255892; Fournier AM; Carmichael C; Department of Family Medicine and Community Health, University of; Miami School of Medicine, Miami Beach, Fla 33101, USA.; Worldwide, and in pockets of poverty in the United States , there is growing evidence that poverty is a major contributor to the spread of human immunodeficiency virus infection. Specific socioeconomic forces contributing to the spread of the infection include the status of women, prost
Longitudinal models for AIDS marker data.: Stat Methods Med Res. 1998 Mar;7(1):13-27. Unique Identifier : AIDSLINE MED/98194458; Boscardin WJ; Taylor JM; Law N; Department of Biostatistics, UCLA 90095-1772, USA.; Over the past decade, researchers have put a great amount of effort into developing suitable models for the analysis of longitudinal CD4 data and other markers of AIDS progression. These models must be general enough to allow for different patterns of change in the marker data. In this paper, we review the existing li
Increasing efficiency from censored survival data by using random effects to model longitudinal covariates.: Stat Methods Med Res. 1998 Mar;7(1):28-48. Unique Identifier : AIDSLINE MED/98194459; Hogan JW; Laird NM; Center for Statistical Sciences, Brown University, Providence, RI; 02912, USA. jhogan@stat.brown.edu; When estimating a survival time distribution, the loss of information due to right censoring results in a loss of efficiency in the estimator. In many circumstances, however, repeated measurements on a longitudinal process which is associated with survival time are made throughout the observation time, and these measu
Malignant melanoma in an HIV-infected man: a case report and literature review.: Cancer Invest. 1998;16(4):217-24. Unique Identifier : AIDSLINE MED/98250917; Aboulafia DM; Section of Hematology/Oncology, Virginia Mason Medical Center,; Seattle, Washington, USA.; Although it is not proven by causative association, several studies indicate that patients with acquired immune deficiency syndrome (AIDS) have a high risk for developing cutaneous malignancies, especially lymphoma and Kaposi s sarcoma. Other malignant cutaneous lesions seen in this patient population include basal-ce
Skin and soft tissue infections in critical care.: Crit Care Clin. 1998 Apr;14(2):251-62. Unique Identifier : AIDSLINE MED/98222629; Hill MK; Sanders CV; Department of Medicine, Louisiana State University School of Medicine,; New Orleans, USA.; Clinicians in the critical care setting see extensive, severe, and often necrotizing infection, as well as atypical or unusual infection that can be misdiagnosed, resulting in delays in treatment. Greater numbers of immunocompromised patients are at risk for both types of infection. A thorough understanding of various
Genetic effects on HIV disease progression [letter]: Nat Med. 1998 May;4(5):536. Unique Identifier : AIDSLINE MED/98244606; Ioannidis JP; O'Brien TR; Rosenberg PS; Contopoulos-Ioannidis DG; Goedert JJ
Are Japanese researchers exploiting Thai HIV patients? [news]: Nat Med. 1998 May;4(5):540. Unique Identifier : AIDSLINE MED/98244610; Saegusa A
Funding for Gallo Institute under threat [news]: Nat Med. 1998 May;4(5):541. Unique Identifier : AIDSLINE MED/98244612; Ault A
Chemokines and HIV-1 second receptors: the therapeutic connection.: Nat Med. 1998 May;4(5):563-8. Unique Identifier : AIDSLINE MED/98244628; Cairns JS; D'Souza MP; Targeted Intervention Branch, Division of AIDS, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
B cells inhibit induction of T cell-dependent tumor immunity.: Nat Med. 1998 May;4(5):627-30. Unique Identifier : AIDSLINE MED/98244640; Qin Z; Richter G; Schuler T; Ibe S; Cao X; Blankenstein T; Max-Delbruck-Center for Molecular Medicine, Berlin, FRG.; Cytotoxic T lymphocyte (CTL) mediated tumor immunity against major histocompatibility antigen (MHC) class I-positive but class II-negative tumors often requires help from CD4+ T cells. These CD4 cells are activated by MHC class II-positive cells that present tumor derived antigens. Considering that different antigen p
Sharps injuries in dental practice.: Prim Dent Care. 1998 Jan;5(1):33-9. Unique Identifier : AIDSLINE MED/98187014; Robinson P; United Medical and Dental Schools of Guy's and St. Thomas's, London.; Sharps injuries are common in dental practice and may allow transmission of blood-borne viruses. The transmission rates of hepatitis B (HBV) to non-vaccinated recipients, hepatitis C (HCV) and human immunodeficiency virus (HIV) after a needlestick injury are 6-30%, 2.7-10% and 0.1-0.3% respectively. Five strategies to
Remune response [letter]: Nat Biotechnol. 1998 Apr;16(4):314. Unique Identifier : AIDSLINE MED/98216555; Trauger R
Binding kinetics and bioassay of RRE mRNA fragments to a peptide containing the recognition domain of HIV-1 Rev.: Biomed Pept Proteins Nucleic Acids. 1996-97;2(3):85-8. Unique Identifier : AIDSLINE MED/98236257; West ML; Ramsdale TE; Centre for Drug Design and Development, University of Queensland, St.; Lucia, Australia.; Surface plasmon resonance techniques have been used to examine the kinetics of binding for two RNA fragments to an RNA binding domain of HIV-1 REv. RBE3 RNA elicited an apparent dissociation constant (KD) of 121 nM while RREIIB41-79 RNA exhibited an apparent dissociation constant (KD) of 2.5 nM. The dissociation rates
Communicable diseases surveillance.: Commun Dis Intell. 1998 Apr 16;22(4):61-7. Unique Identifier : AIDSLINE MED/98244097
Open-label phase I study of combination therapy with zidovudine and interferon-beta in patients with AIDS-related Kaposi's sarcoma: AIDS Clinical Trials Group Protocol 057.: Cytokines Cell Mol Ther. 1998 Mar;4(1):17-23. Unique Identifier : AIDSLINE MED/98217966; Miles S; Levine A; Feldstein M; Carden J; Cabriallas S; Marcus S; Mitsuyasu R; Gill P; Division of Hematology-Oncology, UCLA Clinical AIDS Research and; Education Center, UCLA School of Medicine, USA.; smiles@medl.medsch.ucla.edu; The aim of this study was to identify a safe and tolerable dose of recombinant interferon-beta (IFN-beta) used in conjunction with a fixed dose of zidovudine in patients with early-stage, good-prognosis AIDS-related Kaposi s sarcoma. We conducted a phase I, dose-escalation controlled trial of 22.5, 45 of 90 million un
Irradiated IL-2 gene-modified plasmacytoma vaccines are more efficient than live vaccines.: Int J Oncol. 1998 May;12(5):1195-8. Unique Identifier : AIDSLINE MED/98207192; Simova J; Bubenik J; Jandlova T; Indrova M; Institute of Molecular Genetics, Academy of Sciences of the Czech; Republic, Flemingovo nam. 2, 166 37 Prague 6, Czech Republic.; The effect of irradiation on the therapeutic efficacy of IL-2 gene-modified plasmacytoma cells used as a vaccine in the immunotherapy of parental murine plasmacytoma X63-Ag8.653 was examined. Local administration of the IL-2-secreting plasmacytoma irradiated with a dos
It's more than literacy: the assimilation effect of the translation model.: Ethn Health. 1997 Nov;2(4):323-8. Unique Identifier : AIDSLINE MED/98187443; Saini F; Rowling L; Northern Sydney Area Health Service, Royal North Shore Hospital, St; Leonards, Australia.; Availability and access to correct information is a pre-requisite for people to be able to make informed decisions about their health. This paper will examine the effect of the sole reliance on translation in producing health promotion materials for people from Non English Speaking Background (NESB). In
How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis.: Int J Tuberc Lung Dis. 1998 Jan;2(1):10-5. Unique Identifier : AIDSLINE MED/98220574; Mitchison DA; Department of Medical Microbiology, St. George's Hospital Medical; School, London, UK. dmitchis@sghms.ac.uk; OBJECTIVE: To explore mechanisms by which drug resistance might arise as a result of poor compliance during short course chemotherapy. DESIGN: Four theoretical mechanisms are first described. RESULTS: Examples of the way the mechanisms probably operate are taken from: 1) a study of once-weekly chemotherapy with strept
The use of restriction fragment length polymorphism (RFLP) analysis for epidemiological studies of tuberculosis in developing countries.: Int J Tuberc Lung Dis. 1998 Jan;2(1):16-26. Unique Identifier : AIDSLINE MED/98220575; Cohn DL; O'Brien RJ; Research and Surveillance Unit, Global Tuberculosis Programme, World; Health Organization, Geneva, Switzerland.; DNA fingerprinting, of which restriction fragment length polymorphism (RFLP) typing is the most common method used, has permitted novel investigations of the epidemiology and pathogenesis of tuberculosis. The use of IS6110, an insertion sequence which is present in Mycobacterium tuberculosis, is generally considered t
The International Tuberculosis Surveillance Research Unit (TSRU): the first 30 years.: Int J Tuberc Lung Dis. 1998 Jan;2(1):5-9. Unique Identifier : AIDSLINE MED/98220573; Rouillon A; International Union Against Tuberculosis and Lung Disease, Paris,; France. IUATLDParis@compuserve.com
[Methods and perspectives of AIDS prevention among teachers of secondary schools in the village of Namur]: Sante Publique. 1997 Dec;9(4):475-82. Unique Identifier : AIDSLINE MED/98245546; Meremans P; Sace C; Brasseur P; Deccache A; Universite Catholique de Louvain-en-Woluwe, Belgique.; In 1994, ASBL Namur-Entraide-Sida has been involved in a survey through questionnaires for teachers of the whole high schools in Namur ( Belgium ). Its purpose was to better notice what sort of viewpoints and modalities in preventing youngs from aids were developed or not during the
Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella.: Chem Pharm Bull (Tokyo). 1998 Apr;46(4):684-6. Unique Identifier : AIDSLINE MED/98240207; Ohta K; Mizushina Y; Hirata N; Takemura M; Sugawara F; Matsukage A; Yoshida S; Sakaguchi K; Department of Applied Biological Science, Faculty of Science and; Technology, Science University of Tokyo, Japan.; A new sulfolipid, KM043, which belongs to the 6-sulfo-alpha-D-quinovopyranosyl-(1-->3 )-1 ,2 -diacylglycerol SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as a potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1. Its structure was determined on t
Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120.: Chem Pharm Bull (Tokyo). 1998 Apr;46(4):697-703. Unique Identifier : AIDSLINE MED/98240208; Asagarasu A; Uchiyama T; Achiwa K; School of Pharmaceutical Sciences, University of Shizuoka, Japan.; Some HIV-protease inhibitor derivatives having an N-carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CP
Practical synthesis of (2s,3s)-3-amino-2-hydroxy-4-phenylbutyric acid, a key component of HIV protease inhibitors.: Chem Pharm Bull (Tokyo). 1998 Apr;46(4):733-5. Unique Identifier : AIDSLINE MED/98240215; Shibata N; Itoh E; Terashima S; Sagami Chemical Research Center, Sagamihara, Kanagawa, Japan.
Brain HIV burden and length of survival after AIDS diagnosis.: Clin Neuropathol. 1998 Mar-Apr;17(2):95-9. Unique Identifier : AIDSLINE MED/98222115; Soontornniyomkij V; Nieto-Rodriguez JA; Martinez AJ; Kingsley LA; Achim CL; Wiley CA; Department of Pathology (Division of Neuropathology), University of; Pittsburgh, Pennsylvania 15213, USA.; Patients with AIDS in the late stages of disease can develop dementia . Previous studies have suggested HIV encephalitis is the pathological substrate of HIV-associated dementia. We hypothesized that patients who survive longer after the initial diagnosis of AIDS would have a higher
Effects of methylprednisolone and cyclophosphamide pulse therapy on renal infiltrating cells in patients with crescentic glomerulonephritis.: Chin Med J (Engl). 1997 Mar;110(3):206-9. Unique Identifier : AIDSLINE MED/98256698; Tang Z; Zhou H; Yao X; Hu W; Leishi L; Jinling Hospital, School of Medicine, Nanjing University, China.; OBJECTIVE: To investigate the effects of pulse methylprednisolone MP) and monthly intravenous cyclophosphamide (CTX) therapy (MP + CTX) on renal infiltrating cells in patients with rapid progressive glomerular nephritis (RPGN). METHODS: Twelve patients with RPGN (> 50% crescents) were given MP + CTX therapy and receiv
Vaccination with monoclonal anti-idiotypic antibody on immunocompetent mice bearing human ovarian carcinoma.: Chin Med J (Engl). 1997 Apr;110(4):259-63. Unique Identifier : AIDSLINE MED/98256580; Qian H; Wang J; Feng J; Gynecologic Oncology Center, People's Hospital, Beijing Medical; University, China.; OBJECTIVE: To observe the effects of anti-idiotypic monoclonal antibody 6B11 against ovarian carcinoma SKOV3 on immunocompetent mice BCF1 both in vivo and in vitro, so as to investigate the possibility of using it as a tumor vaccine. METHODS: After immunization with 6B11 and normal mice (NM) IgG respectively on 2 grou
Emerging pathogens: the Hong Kong experience.: Chin Med J (Engl). 1997 Jul;110(7):560-6. Unique Identifier : AIDSLINE MED/98256572; Siau H; Yuen KY; Peiris JS; Wong SS; Ho PL; Cao L; Yam WC; Shortridge KF; Chau PY; Im SW; Ng MH; Department of Microbiology, University of Hong Kong, Queen Mary; Hospital Compound.
[Effect of bone xenograft transplantation on total T lymphocyte and its subset counts in mouse blood and spleen]: Chung Hua Wai Ko Tsa Chih. 1996 Aug;34(8):453-6. Unique Identifier : AIDSLINE MED/98256543; Sang H; Hu Y; Xia H; Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical; University, Xi'an.; Fresh calf cancellous bone xenograft (FX), antigen free cancellous bone carrier (BC) and reconstituted bone xenograft RBX) were inplanted in the thigh muscle pouches of Balb/c mice. Histological examinations were done at 7, 14 and 28 days postoperation, and indirect immunofluorescence was used to determine the positiv
Perianal manifestations of human immunodeficiency virus infection: experience with 260 patients.: Dis Colon Rectum. 1998 May;41(5):606-11; discussion 611-2. Unique Identifier : AIDSLINE MED/98254076; Barrett WL; Callahan TD; Orkin BA; Department of Surgery, The George Washington University, Washington,; DC, USA.; PURPOSE: Individuals infected with the human immunodeficiency virus often have disorders affecting the anorectum. These disorders may be complex and difficult to treat. We reported our early experience with 40 human immunodeficiency virus-positive patients with perianal disorders in 1990. We now present our series of
Cytomegalovirus enteritis: a highly lethal condition requiring early detection and intervention.: Dis Colon Rectum. 1998 May;41(5):619-23. Unique Identifier : AIDSLINE MED/98254078; Page MJ; Dreese JC; Poritz LS; Koltun WA; Department of Surgery, Milton S. Hershey Medical Center, Pennsylvania; State University College of Medicine, Hershey 17033-0850, USA.; Cytomegalovirus infection causing symptomatic enteritis is most usually associated with immunosuppressed transplant patients or patients positive for human immunodeficiency virus. Most reports studying this illness are small and do not clearly define the risk factors or mortality rates. METHODS: The present study retr
Affinity capillary electrophoresis investigation of an epitope on human immunodeficiency virus recognized by a monoclonal antibody.: Electrophoresis. 1998 Mar;19(3):415-9. Unique Identifier : AIDSLINE MED/98211519; Qian XH; Tomer KB; Laboratory of Structural Biology, National Institute of Environmental; Health Sciences, Research Triangle Park, NC 27709, USA.; Affinity capillary electrophoresis (ACE) has been used to investigate the epitope on the human immunodeficiency virus (HIV) core protein p24 recognized by the monoclonal antibody (mAb) 13-102-100. The affinity of a series of peptides with N- and C-terminal truncations of the epitope sequence determined by mass spectro
The Ick protein tyrosine kinase is not involved in antibody-mediated CD4 (CDR3-loop) signal transduction that inhibits HIV-1 transcription.: Eur J Immunol. 1998 May;28(5):1445-57. Unique Identifier : AIDSLINE MED/98264612; Coudronniere N; Corbeil J; Robert-Hebmann V; Mesnard JM; Devaux C; CRBM/CNRS UPR 1086-Laboratoire Infections retrovirales et; signalisation cellulaire, Montpellier, France.; Monoclonal antibodies (mAb) that bind to the immunoglobulin CDR3-like region in the D1 domain of the CD4 molecule can inhibit the HIV-1 life cycle in CD4-positive T cells and lymphoblastoid cell lines at the stage of transcription. This antiviral effect requires the integrity of the cytoplasmic tail of CD4 which is kn
Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells.: Eur J Immunol. 1998 May;28(5):1492-8. Unique Identifier : AIDSLINE MED/98264616; Mariani SM; Krammer PH; Division of Immunogenetics, German Cancer Research Center, Heidelberg.; Like other members of the TNF family, TRAIL/Apo-2 ligand induces apoptosis in sensitive target cells in a caspase-dependent fashion. We recently found that TRAIL may be constitutively expressed on the surface of mouse and human tumor cells of T and B origin. To define the pattern of TRAIL expression in normal immune c
Enforced expression of human bcl-2 in CD4+ T cells enhances human herpesvirus 7 replication and induction of cytopathic effects.: Eur J Immunol. 1998 May;28(5):1587-96. Unique Identifier : AIDSLINE MED/98264627; Secchiero P; Bertolaso L; Gibellini D; Ricci D; Bemis K; Capitani S; Gallo RC; Zauli G; Institute of Human Anatomy, University of Ferrara, Italy.; The cytopathic effects (CPE) resulting from the infection of CD4+ T cells by human herpes-virus 7 (HHV-7) comprises two major mechanisms: generation of large polyploid cells, which eventually undergo necrotic lysis, and apoptosis, predominantly occurring in small mononucleated cells. To dissect the relative contributi
Somatic hypermutation of the T cell receptor V beta gene in microdissected splenic white pulps from HIV-1-positive patients.: Eur J Immunol. 1998 May;28(5):1604-10. Unique Identifier : AIDSLINE MED/98264629; Cheynier R; Henrichwark S; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris, France.; Somatic mutation of rearranged immunoglobulin V genes occurs in germinal centers (GC), resulting in affinity maturation of the immune response. Rearranged T cell receptor (TCR) genes were thought to be excluded from this process despite similarities in their gene structure. Somatic mutations were found among TCR V alp
ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains.: Eur J Immunol. 1998 May;28(5):1689-700. Unique Identifier : AIDSLINE MED/98264639; Samson M; Edinger AL; Stordeur P; Rucker J; Verhasselt V; Sharron M; Govaerts C; Mollereau C; Vassart G; Doms RW; Parmentier M; IRIBHN, Universite libre de Bruxelles, Belgium.; Leukocyte chemoattractants act through a rapidly growing subfamily of G protein-coupled receptors. We report the cloning of a novel human gene encoding an orphan receptor (ChemR23) related to the C3a, C5a and formyl Met-Leu-Phe receptors, and more distantly to the subfamilies of chemokine receptors. ChemR23 transcript
Demonstration of identical expanded clones within both CD8+CD28+ and CD8+CD28- T cell subsets in HIV type 1-infected individuals.: Eur J Immunol. 1998 May;28(5):1738-42. Unique Identifier : AIDSLINE MED/98264644; Mugnaini EN; Spurkland A; Egeland T; Sannes M; Brinchmann JE; Institute of Transplantation Immunology, Rikshospitalet National; Hospital, Oslo, Norway.; In HIV-1-infected individuals, the CD8+CD28- T cell subset is considerably expanded and is frequently the largest subset of T cells found in peripheral blood. It has been assumed, but not proven, that CD8+CD28- T cells derive from CD8+CD28+ T cells in vivo. To further study the ontogeny of CD8+CD28- T cells, we have p
Depletion of EBV-infected cells in donor marrow by counterflow elutriation.: Exp Hematol. 1998 May;26(5):395-9. Unique Identifier : AIDSLINE MED/98250537; Gross TG; Hinrichs SH; Davis JR; Mitchell D; Bishop MR; Wagner JE; Department of Pathology/Microbiology, UNMC/Eppley Cancer Center,; University of Nebraska Medical Center, Omaha 68198, USA.; Epstein-Barr virus (EBV)-associated posttransplantation lymphoproliferative disease (PTLD) is a well-recognized complication of T cell-depleted (TCD) allogeneic bone marrow transplantation (BMT). Certain methods of TCD, such as counterflow elutriation (CE), have not been associated with an increased incidence of PTLD.
Encephalitozoon intestinalis: humoral responses in interferon-gamma receptor knockout mice infected with a microsporidium pathogenic in AIDS patients.: Exp Parasitol. 1998 May;89(1):113-21. Unique Identifier : AIDSLINE MED/98264659; El Fakhry Y; Achbarou A; Desportes-Livage I; Mazier D; INSERM U313, Immunobiologie Cellulaire et Moleculaire des Infections; Parasitaires, CHU Pitie-Salpetriere, Paris, France.; IFN-gamma receptor knockout mice and wild-type mice were infected per os with Encephalitozoon intestinalis. Both groups developed an infection that was chronic in the mutant mice whereas it was only transient in wild-type mice. The infection of mutant mice was characterized by the continual shedding of spores in feces
Genomic organization and promoter characterization of human CXCR4 gene.: FEBS Lett. 1998 Apr 17;426(2):271-8. Unique Identifier : AIDSLINE MED/98258970; Caruz A; Samsom M; Alonso JM; Alcami J; Baleux F; Virelizier JL; Parmentier M; Arenzana-Seisdedos F; Unite d'Immunologie Virale, Institut Pasteur, Paris, France.; CXCR4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. Recently, CXCR4 has drawn unexpected attention as it was recently identified as a co-factor required for entry of lymphotropic HIV isolates in CD4+ T lymphocytes.
Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene.: Genetics. 1998 Mar;148(3):929-36. Unique Identifier : AIDSLINE MED/98198821; Nielsen R; Yang Z; Department of Integrative Biology, University of California, Berkeley; 94720-3140, USA. rasmus@mws4.biol.berkeley.edu; Several codon-based models for the evolution of protein-coding DNA sequences are developed that account for varying selection intensity among amino acid sites. The neutral model assumes two categories of sites at which amino acid replacements are either neutral or deleterious. The positive-selection model assumes
[New herpesviruses HHV 6, 7 and 8 and their clinical significance]: Fortschr Med. 1998 Feb 20;116(5):37-9. Unique Identifier : AIDSLINE MED/98213917; Menz M; Eggers HJ; Universitat zu Koln, Institut fur Virologie, Koln.
Transitions in insurance and employment among people with HIV infection.: Inquiry. 1998 Spring;35(1):36-48. Unique Identifier : AIDSLINE MED/98259304; Fleishman JA; Center for Cost and Financing Studies, Agency for Health Care Policy; and Research, Rockville, MD 20852, USA.; This article examines the extent to which people with HIV infection change their insurance and employment status over time and investigates the correlates of such changes. Data come from the AIDS Cost and Services Utilization Survey, which followed 1,949 HIV-infected adults over an 18-month period that began March 1,
Human papillomavirus and human immunodeficiency virus infections: relation with cervical dysplasia-neoplasia in African women.: Int J Cancer. 1998 May 18;76(4):480-6. Unique Identifier : AIDSLINE MED/98250003; La Ruche G; You B; Mensah-Ado I; Bergeron C; Montcho C; Ramon R; Toure-Coulibaly K; Welffens-Ekra C; Dabis F; Orth G; Programme National de Lutte contre le SIDA, Abidjan, Cote d'Ivoire.; Our study assessed the factors associated with cervical squamous intra-epithelial lesions (SILs) and invasive cervical cancer, with special attention to human immunodeficiency virus (HIV) and human papillomavirus (HPV) infections. Women from 3 outpatient gynecology clinics of Abidjan,
Sulfated glycoglycerolipid from archaebacterium inhibits eukaryotic DNA polymerase alpha, beta and retroviral reverse transcriptase and affects methyl methanesulfonate cytotoxicity.: Int J Cancer. 1998 May 18;76(4):512-8. Unique Identifier : AIDSLINE MED/98250009; Ogawa A; Murate T; Izuta S; Takemura M; Furuta K; Kobayashi J; Kamikawa T; Nimura Y; Yoshida S; First Department of Surgery, Nagoya University School of Medicine,; Japan.; A sulfated glycoglycerolipid, 1-O-(6 -sulfo-alpha-D-glucopyranosyl)-2,3-di-O-phytanyl- sn-glycerol (KN-208), a derivative of the polar lipid isolated from an archaebacterium, strongly inhibited DNA polymerase (pol) alpha and pol beta in vitro among 5 eukaryotic DNA polymerases alpha, beta, gamma, delta, and epsilon).
Thymic anti-tumor effectors in mice cured of lymphoma by cyclophosphamide plus TNF-alpha therapy: phenotypic and functional characterization up to 20 months after initial tumor inoculation.: Int J Cancer. 1998 May 18;76(4):579-86. Unique Identifier : AIDSLINE MED/98250019; Ehrke MJ; Verstovsek S; Pocchiari SK; Krawczyk CM; Ujhazy P; Zaleskis G; Maccubbin DL; Meer JM; Mihich E; Department of Experimental Therapeutics, Grace Cancer Drug Center,; Roswell Park Cancer Institute, Buffalo, NY 14263, USA.; Ehrke@SC3101.Med.Buffalo.edu; As reported previously, cyclophosphamide plus tumor necrosis factor-alpha treatment of C57BL/6 mice bearing advanced EL4 lymphoma induced approx. 60% long-term (i.e., >60 days) survivors. These mice developed protective immunity, as evidenced by 1) rejection (100% survival) of EL4 tumor re-implanted on day 60 (day 0 =
Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats.: Int J Cancer. 1998 May 18;76(4):595-600. Unique Identifier : AIDSLINE MED/98250021; Hatse S; Naesens L; Degreve B; Segers C; Vandeputte M; Waer M; De Clercq E; Balzarini J; Rega Institute for Medical Research, Katholieke Universiteit, Leuven,; Belgium.; The acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective antiretroviral agent which is currently evaluated in its oral prodrug form, bis(POM)PMEA (adefovir dipivoxil), in phase II and III clinical trials in human hepatitis B virus HBV)- and human immunodeficiency virus (H
Psychological distress in HIV-1 disease in relationship to hypocholesterolemia.: Int J Psychiatry Med. 1997;27(2):159-71. Unique Identifier : AIDSLINE MED/98226842; Shor-Posner G; Baldewicz T; Feaster D; Blaney NT; Miguez-Burbano M; Szapocznik J; Goodkin K; Eisdorfer C; Baum MK; Department of Psychiatry and Behavioral Sciences, University of Miami; School of Medicine, FL 33101, USA.; OBJECTIVE: Altered levels of serum cholesterol, which are prevalent in early HIV-1 infection, have been associated with disturbances in mood state and behavior. The objective of this study was to evaluate the relationship of serum cholesterol status and psychological distress in HIV-1 seropositive and seronegative men
[Costs of accidental punctures in hospital health personnel]: Gac Sanit. 1998 Jan-Feb;12(1):29-38. Unique Identifier : AIDSLINE MED/98247528; Solano Bernad VM; Rubio Cebrian S; Hernandez Navarrete MJ; Peral Casado A; Sierra Moros MJ; Castan Cameo S; Arribas Llorente JL; Servicio de Medicina Preventiva, Hospital Miguel Servet, Zaragoza.; OBJECTIVES: The aim of this study was to calculate the average cost of each hepatitis B, C and HIV follow-up carried out in the health personnel that have suffered an exposure to blood and body fluids and to estimate the cost for each of the different types of sources as well as to identify the items that account for
IMS supports name-specific HIV reports.: Iowa Med. 1998 Mar-Apr;88(2):12. Unique Identifier : AIDSLINE MED/98210384
CDC reports first-ever decline in AIDS diagnoses--treatment and prevention advances spur new trend [news]: J Ark Med Soc. 1998 Feb;94(9):388-9. Unique Identifier : AIDSLINE MED/98211139
HIV seropositivity in a burn center's population.: J Burn Care Rehabil. 1998 Mar-Apr;19(2):138-41. Unique Identifier : AIDSLINE MED/98215604; Mele JA 3rd; Linder SA; Calabria R; Ikeda CJ; Division of Plastic and Reconstructive Surgery, Saint Francis Memorial; Hospital, San Francisco, CA 94109, USA.; HIV infection in a patient with burn injuries complicates the care of both the patient and the treating burn team. In the patient, HIV slows wound healing and increases the complications seen with burns. For the treating team, HIV is a hazard that infects the large volume of bodily fluids to which the burn team is pot
In situ polymerase chain reaction amplification of HIV-1 DNA in brain tissue.: J Virol Methods. 1998 Feb;70(2):119-27. Unique Identifier : AIDSLINE MED/98220877; Strappe PM; Wang TH; McKenzie CA; Lowrie S; Simmonds P; Bell JE; Department of Pathology, University of Edinburgh, Western General; Hospital, UK.; A direct in situ polymerase chain reaction (IS-PCR) assay is described for the detection of HIV-1 proviral DNA in formalin fixed paraffin embedded brain tissue. Biotin-16-dUTP is incorporated during the PCR process and microwave pretreatment of tissue sections ensures that no non-specific incorporation into damaged or
Evaluation of 14 commercial HIV-1/HIV-2 antibody assays using serum panels of different geographical origin and clinical stage including a unique seroconversion panel.: J Virol Methods. 1998 Feb;70(2):139-51. Unique Identifier : AIDSLINE MED/98220879; Thorstensson R; Andersson S; Lindback S; Dias F; Mhalu F; Gaines H; Biberfeld G; Swedish Institute for Infectious Disease Control and Karolinska; Institute, Stockholm. rigmor.thorstensson@smi.ki.se; The performance of 14 commercially available HIV-1/2 antibody assays were compared using well-characterized serum panels containing in total 1500 1800 sera. The panels included consecutive HIV-negative blood donor sera from Sweden , unselected blood donor and patient sera from
Diagnosis of human immunodeficiency virus infection by a polymerase chain reaction assay evaluated in patients harbouring strains of diverse geographical origin.: J Virol Methods. 1998 Feb;70(2):153-66. Unique Identifier : AIDSLINE MED/98220880; Van Laethem K; Beuselinck K; Van Dooren S; De Clercq E; Desmyter J; Vandamme AM; Department of Microbiology and Immunology, Rega Institute for Medical; Research and University Hospitals, Katholieke Universiteit Leuven,; Belgium.; Since the development of the highly sensitive polymerase chain reaction, PCR has been increasingly used for the diagnosis of viral infections, including the detection of human immunodeficiency virus (HIV), the causative agent of AIDS. In our laboratory a diagnostic PCR is carried out on proviral HIV-1 DNA using a stan
Development of a syncytia inhibition assay for the detection of antibodies to bovine leukemia virus in naturally infected cattle; comparison with Western blot and agar gel immunodiffusion.: J Virol Methods. 1998 Feb;70(2):177-82. Unique Identifier : AIDSLINE MED/98220882; Johnson M; Rommel F; Mone J; Department of Biology, Millersville University, PA 17551, USA.; A syncytia inhibition assay (SIA) for the detection of antibodies to bovine leukemia virus is described. This test involves specific antibody-mediated inhibition of BLV-induced cytopathic effects in an indicator cell line. A total of 300 sera were screened commercially by agar gel immunodiffusion (AGID) and were then
Effects of chronic growth hormone treatment on energy intake and resting energy metabolism in patients with human immunodeficiency virus-associated wasting--a clinical research center study.: J Clin Endocrinol Metab. 1998 May;83(5):1542-7. Unique Identifier : AIDSLINE MED/98251563; Mulligan K; Tai VW; Schambelan M; Division of Endocrinology, San Francisco General Hospital, California; 94110, USA.; In previous studies, treatment with recombinant human GH (rhGH) produced sustained increases in weight and lean body mass (LBM) and decreases in fat mass in patients with human immunodeficiency virus (HIV)-associated wasting. To evaluate the effects of chronic rhGH treatment on components of energy balance, we recruit
Chronic cryptosporidiosis in patients with AIDS: stable remission and possible eradication after long-term, low dose azithromycin.: J Clin Pathol. 1998 Feb;51(2):138-42. Unique Identifier : AIDSLINE MED/98265398; Dionisio D; Orsi A; Sterrantino G; Meli M; Di Lollo S; Ibba Manneschi L; Trotta M; Pozzi M; Sani L; Leoncini F; Infectious Diseases Unit, Careggi Hospital, Florence, Italy.; AIMS: To investigate the effectiveness of long term, low dose azithromycin treatment for chronic cryptosporidiosis in patients with AIDS. METHODS: Azithromycin was administered as initial daily treatment to 13 patients with AIDS: 6 patients received 500 mg for 30 to 40 days (mean 35); 3 patients received 1000 mg for 2
Differentiation between actinic reticuloid and cutaneous T cell lymphoma by T cell receptor gamma gene rearrangement analysis and immunophenotyping.: J Clin Pathol. 1998 Feb;51(2):154-8. Unique Identifier : AIDSLINE MED/98265401; Bakels V; van Oostveen JW; Preesman AH; Meijer CJ; Willemze R; Department of Dermatology, Free University Hospital, Amsterdam,; Netherlands.; AIMS: Differentiation between actinic reticuloid and cutaneous T cell lymphoma can be extremely difficult. Demonstration of clonal T cell receptor (TCR) gene rearrangements has been suggested as a potential diagnostic criterion, but the results obtained thus far have been conflicting. This study investigated whether T
Follicular mucinosis as a presenting sign of acute myeloblastic leukemia.: J Am Acad Dermatol. 1998 May;38(5 Pt 2):803-5. Unique Identifier : AIDSLINE MED/98252487; Sumner WT; Grichnik JM; Shea CR; Moore JO; Miller WS; Burton CS; Department of Medicine, Duke University Medical Center, Durham, NC; 27710, USA.; Follicular mucinosis is often associated with mycosis fungoides and has been rarely observed to occur with other neoplastic and inflammatory conditions. We describe a 60-year-old patient with follicular mucinosis who later developed acute myelogenous leukemia. This is the first reported case of follicular mucinosis as
Degos disease in a patient with acquired immunodeficiency syndrome.: J Am Acad Dermatol. 1998 May;38(5 Pt 2):852-6. Unique Identifier : AIDSLINE MED/98252499; Requena L; Farina C; Barat A; Department of Dermatology, Fundacion Jimenez Diaz, Universidad; Autonoma, Madrid, Spain.; Malignant atrophic papulosis is a rare disorder characterized by pathognomonic cutaneous lesions that consist of infarctive thrombosis. Visceral involvement often occurs; the gastrointestinal tract and the central nervous system are most frequently involved. Malignant atrophic papulosis has not been previously describ
Evaluation of an HIV/AIDS continuing education program.: J Contin Educ Nurs. 1998 Mar-Apr;29(2):85-93. Unique Identifier : AIDSLINE MED/98243583; Sowell R; Seals G; Wilson B; Robinson C; Department of Administrative and Clinical Nursing, University of South; Carolina, Columbia, USA.; An HIV/AIDS education model was implemented for rural nurses as a demonstration project in Georgia. The overall goal of the project was to increase the quality of and access to HIV/AIDS-specific services in rural communities. Public health and community nurses were the focus of this effort due to their current roles i
HIV-associated eosinophilic pustular folliculitis: successful treatment of a Japanese patient with UVB phototherapy.: J Dermatol. 1998 Mar;25(3):178-84. Unique Identifier : AIDSLINE MED/98236594; Misago N; Narisawa Y; Matsubara S; Hayashi S; Department of Internal Medicine, Saga Medical School, Japan.; We report the successful treatment with ultraviolet B phototherapy of a patient with HIV-associated eosinophilic pustular folliculitis. We were able to observe the clinical and therapeutic course for about one year and three months. This 35-year-old homosexual Japanese man presented with disseminated, discrete, follic
Neutrophil eccrine hidradenitis in a patient with AIDS.: J Dermatol. 1998 Mar;25(3):199-200. Unique Identifier : AIDSLINE MED/98236598; Krischer J; Rutschmann O; Roten SV; Harms M; Saurat JH; Pechere M; Clinic of Dermatology, University Hospital Geneva, Switzerland.; Neutrophilic eccrine hidradenitis (NEH), first described as a rare, transient, and benign complication of various chemotherapy regimens for acute leukemia, has also been observed in other conditions, including three HIV-positive patients and even in otherwise healthy individuals (1-3). A similar histological pattern w
AIDS discourse: a critical reading of mainstream press surveillance of marginal identity.: J Homosex. 1998;35(1):75-93. Unique Identifier : AIDSLINE MED/98185606; Myrick R; Department of Communication, Auburn University, AL 36849-5211, USA.; This article examines the discursive strategies used by two major daily newspapers from the South from 1981 to 1994 as they construct the story of AIDS and represent gay identity and desire to the general public. The research employs a cultural studies approach to communication to analyze power relationships at work
"Semi-straight sort of sex": class and gay community attachment explored within a framework of older homosexually active men.: J Homosex. 1998;35(2):65-83. Unique Identifier : AIDSLINE MED/98185610; Chapple MJ; Kippax S; Smith G; School of Behavioural Sciences, Macquarie University, Sydney NSW,; Australia.; Gay Community Attachment has proved a significant predictor of successful behavior change among gay-identifying men in response to HIV/AIDS. Related work at Macquarie University, Sydney, Australia , indicated that attachment to gay community is not a simple issue; rather, complex
Mycobacterium terrae: a potential surrogate for Mycobacterium tuberculosis in a standard disinfectant test.: J Hosp Infect. 1998 Mar;38(3):183-92. Unique Identifier : AIDSLINE MED/98222253; Griffiths PA; Babb JR; Fraise AP; Hospital Infection Research Laboratory, City Hospital NHS Trust,; Birmingham, UK.; The susceptibility of Mycobacterium tuberculosis and Mycobacterium avium-intracellulare to the disinfections used for spillage and heat sensitive instruments has received much attention in recent years. The use of clinical isolates of M. tuberculosis and M. avium-intracellulare as test organisms is considered unsuitab
Immunologic abnormalities exhibited in IL-7 transgenic mice with dermatitis.: J Invest Dermatol. 1998 May;110(5):740-5. Unique Identifier : AIDSLINE MED/98239141; Uehira M; Matsuda H; Nakamura A; Nishimoto H; Shionogi Institute for Medical Science, Osaka, Japan.; Interleukin (IL)-7 transgenic mice, which we established previously, developed severe dermatitis characterized by massive infiltration of gammadelta T cells in the dermal lesion. To fully understand the pathology of this intriguing skin disease, we examined several immunologic features of dermis infiltrating lymphocyt
Mutations in the cytomegalovirus UL97 gene associated with ganciclovir-resistant retinitis.: J Infect Dis. 1998 May;177(5):1176-81. Unique Identifier : AIDSLINE MED/98253832; Liu W; Kuppermann BD; Martin DF; Wolitz RA; Margolis TP; F. I. Proctor Foundation and the Department of Ophthalmology,; University of California at San Francisco, 94143-0944, USA.; Vitreous from patients with cytomegalovirus ( CMV ) retinitis was studied in order to identify mutations in the CMV UL97 gene associated with clinical resistance to ganciclovir. Point mutations known to confer resistance (V460,
Lack of reactivation of cytomegalovirus (CMV) retinitis after stopping CMV maintenance therapy in AIDS patients with sustained elevations in CD4 T cells in response to highly active antiretroviral therapy.: J Infect Dis. 1998 May;177(5):1182-7. Unique Identifier : AIDSLINE MED/98253833; Macdonald JC; Torriani FJ; Morse LS; Karavellas MP; Reed JB; Freeman WR; Department of Ophthalmology, University of California, San Diego,; School of Medicine, USA.; The suppression of human immunodeficiency virus (HIV) replication and elevation in CD4 cells observed with protease inhibitor combination regimens known as HAART (highly active antiretroviral therapy) may allow AIDS patients to undergo an immune recovery that allows them to suppress the progression of
Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance.: J Infect Dis. 1998 May;177(5):1207-13. Unique Identifier : AIDSLINE MED/98253837; Maeda Y; Venzon DJ; Mitsuya H; Experimental Retrovirology Section, Medicine Branch, National Cancer; Institute, National Institutes of Health, Bethesda, Maryland 20892,; USA.; Investigations were done to determine whether the replication kinetics of human immunodeficiency virus (HIV)-1 were altered when the virus acquired a set or subsets of five mutations (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene conferring resistance to multiple dideoxynucleosides. In the absence of drugs, the
Distinct determinants of human immunodeficiency virus type 1 RNA and DNA loads in vaginal and cervical secretions.: J Infect Dis. 1998 May;177(5):1214-20. Unique Identifier : AIDSLINE MED/98253838; Iversen AK; Larsen AR; Jensen T; Fugger L; Balslev U; Wahl S; Gerstoft J; Mullins JI; Skinhoj P; Department of Infectious Diseases, Rigshospitalet, National University; Hospital, Copenhagen, Denmark. aifrhm@inet.uni-c.dk; The relationship between human immunodeficiency virus type 1 HIV-1) viral RNA and proviral DNA load in vagina and cervix and that found in the plasma and peripheral blood mononuclear cells PBMC) was investigated in 28 HIV-1-infected women. Of the patients, 64% had > or = 1 HIV-1 RNA-positive genital sample, while 71%
Measurement of human immunodeficiency virus type 1 plasma virus load based on reverse transcriptase (RT) activity: evidence of variabilities in levels of virion-associated RT.: J Infect Dis. 1998 May;177(5):1221-9. Unique Identifier : AIDSLINE MED/98253839; Garcia Lerma JG; Yamamoto S; Gomez-Cano M; Soriano V; Green TA; Busch MP; Folks TM; Heneine W; HIV/Retrovirus Diseases Branch, Division of AIDS, STD, and TB; Laboratory Research, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; Virus load based on levels of functional reverse transcriptase RT) was measured in plasma from 50 human immunodeficiency virus HIV) type 1-infected persons, in 87 samples from 10 HIV-1 seroconversion panels, and in 100 uninfected persons by use of Amp-RT, an ultrasensitive RT assay. Of the 50 clinical samples, 38 (76%
Immune responses to human immunodeficiency virus (HIV) type 1 induced by canarypox expressing HIV-1MN gp120, HIV-1SF2 recombinant gp120, or both vaccines in seronegative adults. NIAID AIDS Vaccine Evaluation Group.: J Infect Dis. 1998 May;177(5):1230-46. Unique Identifier : AIDSLINE MED/98253840; Clements-Mann ML; Weinhold K; Matthews TJ; Graham BS; Gorse GJ; Keefer MC; McElrath MJ; Hsieh RH; Mestecky J; Zolla-Pazner S; Mascola J; Schwartz D; Siliciano R; Corey L; Wright PF; Belshe R; Dolin R; Jackson S; Xu S; Fast P; Walker MC; Stablein D; Excler JL; Tartaglia J; Paoletti E; et al; Johns Hopkins University School of Public Health, Baltimore, Maryland,; USA. mclement@jhsph.edu; A safety and immunogenicity trial was conducted in vaccinia-immune and vaccinia-naive human immunodeficiency virus HIV)-uninfected adults who were randomized to receive 10(6) or 10(7) TCID50 of canarypox (ALVAC) vector expressing HIV-1MN gp160 or 10(5.5) TCID50 of ALVAC-rabies virus glycoprotein control at 0 and 1 or
Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection.: J Infect Dis. 1998 May;177(5):1247-59. Unique Identifier : AIDSLINE MED/98253841; Van Rompay KK; Berardi CJ; Dillard-Telm S; Tarara RP; Canfield DR; Valverde CR; Montefiori DC; Cole KS; Montelaro RC; Miller CJ; Marthas ML; California Regional Primate Research Center, Department of Pathology,; Microbiology, and Immunology, School of Veterinary Medicine,; University of California, Davis 95616-8542, USA.; To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus
The in vitro induction of human immunodeficiency virus (HIV) replication in purified protein derivative-positive HIV-infected persons by recall antigen response to Mycobacterium tuberculosis is the result of a balance of the effects of endogenous interleukin-2 and proinflammatory and antiinflammatory cytokines.: J Infect Dis. 1998 May;177(5):1332-8. Unique Identifier : AIDSLINE MED/98253853; Goletti D; Weissman D; Jackson RW; Collins F; Kinter A; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 20892-2520, USA.; Coinfection with Mycobacterium tuberculosis and human immunodeficiency virus (HIV) is a serious problem, particularly in developing countries. Recently, M. tuberculosis and purified protein derivative (PPD) were demonstrated to induce HIV replication in CD8 T cell-depleted peripheral blood mononuclear cells from HIV-p
A cloned antigen (recombinant K39) of Leishmania chagasi diagnostic for visceral leishmaniasis in human immunodeficiency virus type 1 patients and a prognostic indicator for monitoring patients undergoing drug therapy.: J Infect Dis. 1998 May;177(5):1339-44. Unique Identifier : AIDSLINE MED/98253854; Houghton RL; Petrescu M; Benson DR; Skeiky YA; Scalone A; Badaro R; Reed SG; Gradoni L; Corixa Corp., Seattle, Washington 98104, USA. houghton@corixa.com; Serologic assays using crude antigens for the diagnosis of visceral leishmaniasis in human immunodeficiency virus type 1 HIV)-seropositive patients have been shown to lack sensitivity and specificity, particularly in AIDS patients. Antibodies to a cloned antigen, recombinant (r) K39, of Leishmania chagasi are specific
Naive human T cells develop into Th1 or Th0 effectors and exhibit cytotoxicity early after stimulation with Leishmania-infected macrophages.: J Infect Dis. 1998 May;177(5):1345-51. Unique Identifier : AIDSLINE MED/98253855; Russo DM; Chakrabarti P; Burns JM Jr; Department of Microbiology, Meharry Medical College, Nashville,; Tennessee 37208, USA.; Studies of human disease suggest that naturally acquired immunity is the predominant outcome of Leishmania infection. Normally protective immune mechanisms activated during asymptomatic or self-healing infections may be minimal in patients who develop disease. To explore early immune responses, an in vitro model of hu
Albendazole for treatment and prophylaxis of microsporidiosis due to Encephalitozoon intestinalis in patients with AIDS: a randomized double-blind controlled trial.: J Infect Dis. 1998 May;177(5):1373-7. Unique Identifier : AIDSLINE MED/98253859; Molina JM; Chastang C; Goguel J; Michiels JF; Sarfati C; Desportes-Livage I; Horton J; Derouin F; Modai J; Division of Infectious Diseases, Hopital Saint-Louis, Paris, France.; molina@chu-stlouis.fr; A double-blind placebo-controlled trial was conducted to assess the efficacy and safety of albendazole (400 mg twice daily for 3 weeks) for the treatment of Encephalitozoon intestinalis infection in patients with AIDS. Clearance of microsporidia from the intestinal tract was obtained in 4 of 4 patients in the albendaz
Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment.: J Infect Dis. 1998 May;177(5):1382-5. Unique Identifier : AIDSLINE MED/98253861; Niesters HG; Honkoop P; Haagsma EB; de Man RA; Schalm SW; Osterhaus AD; Department of Gastroenterology, University Hospital Rotterdam, The; Netherlands. niesters@viro.fgg.eur.nl; Lamivudine has been shown to be a potent and nontoxic inhibitor of hepatitis B virus (HBV) replication in chronically infected patients. During prolonged treatment, drug resistance may develop, related to a mutation of Met to Val or Ile in the YM552DD
Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1.: J Infect Dis. 1998 May;177(5):1386-90. Unique Identifier : AIDSLINE MED/98253862; Rosenstein IJ; Stafford MK; Kitchen VS; Ward H; Weber JN; Taylor-Robinson D; Department of Genitourinary Medicine and Communicable Diseases; Jefferiss Research Trust Laboratories), Imperial College School of; Medicine at St. Mary's, London, United Kingdom. ijr30@ic.ac.uk; The effect on normal vaginal flora of three intravaginal microbicides potentially active against human immunodeficiency virus type 1 was examined. Volunteers received dextrin sulfate D2S), nonoxynol-9 (N-9), or docusate sodium in separate placebo-controlled studies. High vaginal swabs were obtained for bacterial cultu
A new look at T cells.: J Exp Med. 1998 May 4;187(9):1367-71. Unique Identifier : AIDSLINE MED/98234418; McMichael AJ; O'Callaghan CA; Institute of Molecular Medicine, Nuffield Department of Medicine, John; Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.; andrew.mcmichael@ndm.ox.ac.uk
Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex.: J Exp Med. 1998 May 4;187(9):1373-81. Unique Identifier : AIDSLINE MED/98234419; Kuroda MJ; Schmitz JE; Barouch DH; Craiu A; Allen TM; Sette A; Watkins DI; Forman MA; Letvin NL; Harvard Medical School, Division of Viral Pathogenesis, Department of; Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; 02215, USA.; A tetrameric recombinant major histocompatibility complex (MHC) class I-peptide complex was used as a staining reagent in flow cytometric analyses to quantitate and define the phenotype of Gag-specific cytotoxic T lymphocytes (CTLs) in the peripheral blood of simian immunodeficiency virus macaque (SIVmac)-infected rhe
Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.: J Exp Med. 1998 May 4;187(9):1383-93. Unique Identifier : AIDSLINE MED/98234420; Gallimore A; Glithero A; Godkin A; Tissot AC; Pluckthun A; Elliott T; Hengartner H; Zinkernagel R; Institute of Experimental Immunology, CH-8091, Zurich, Switzerland.; awen.gallimore@ndm.ox.ac.uk; This study describes the construction of soluble major histocompatibility complexes consisting of the mouse class I molecule, H-2Db, chemically biotinylated beta2 microglobulin and a peptide epitope derived from the glycoprotein (GP; amino acids 33-41) of lymphocytic choriomeningitis virus (LCMV). Tetrameric class I c
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo.: J Exp Med. 1998 May 4;187(9):1395-402. Unique Identifier : AIDSLINE MED/98234421; Callan MF; Tan L; Annels N; Ogg GS; Wilson JD; O'Callaghan CA; Steven N; McMichael AJ; Rickinson AB; Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3; 9DS, United Kingdom.; Primary infection with virus can stimulate a vigorous cytotoxic T cell response. The magnitude of the antigen-specific component versus the bystander component of a primary T cell response remains controversial. In this study, we have used tetrameric major histocompatibility complex-peptide complexes to directly visua
A role for Fas in negative selection of thymocytes in vivo.: J Exp Med. 1998 May 4;187(9):1427-38. Unique Identifier : AIDSLINE MED/98234424; Kishimoto H; Surh CD; Sprent J; Department of Immunology, IMM4, The Scripps Research Institute, 10550; North Torrey Pines Road, La Jolla, California 92037, USA.; To seek information on the role of Fas in negative selection, we examined subsets of thymocytes from normal neonatal mice versus Fas-deficient lpr/lpr mice injected with graded doses of antigen. In normal mice, injection of 1-100 microg of staphylococcal enterotoxin B (SEB) induced clonal elimination of SEB-reactive V
Disturbed CD4+ T cell homeostasis and in vitro HIV-1 susceptibility in transgenic mice expressing T cell line-tropic HIV-1 receptors.: J Exp Med. 1998 May 4;187(9):1439-49. Unique Identifier : AIDSLINE MED/98234425; Sawada S; Gowrishankar K; Kitamura R; Suzuki M; Suzuki G; Tahara S; Koito A; PRESTO, Japan Science and Technology Corporation, and Tsukuba Life; Science Center, The Institute of Physical and Chemical Research; (RIKEN), Tsukuba, Ibaraki 305, Japan. sawada@rtcmain.rtc.riken.go.jp; T cell line-tropic (T-tropic) HIV type 1 strains enter cells by interacting with the cell-surface molecules CD4 and CXCR4. We have generated transgenic mice predominantly expressing human CD4 and CXCR4 on their CD4-positive T lymphocytes (CD4+ T cells). Their primary thymocytes are susceptible to T-tropic but not to m
Overexpression of Ki-67 and cyclins A and B1 in JC virus-infected cells of progressive multifocal leukoencephalopathy.: J Neuropathol Exp Neurol. 1998 Mar;57(3):226-30. Unique Identifier : AIDSLINE MED/98260841; Ariza A; Mate JL; Isamat M; Calatrava A; Fernandez-Vasalo A; Navas-Palacios JJ; Department of Pathology, Hospital Germans Trias i Pujol, Autonomous; University of Barcelona, Spain.; Both SV40 and JC virus (JCV) appropriate the host cell replicative machinery to attend to their own reproductive needs. SV40 large T antigen is able to induce the expression of cyclins A, B1, and E (but not of cylin D1) in transfected diploid cells. Whether JCV infection influences cyclin expression in a similar fashi
Cancer in human immunodeficiency virus-infected children: a case series from the Children's Cancer Group and the National Cancer Institute.: J Clin Oncol. 1998 May;16(5):1729-35. Unique Identifier : AIDSLINE MED/98246297; Granovsky MO; Mueller BU; Nicholson HS; Rosenberg PS; Rabkin CS; Division of Cancer Epidemiology and Genetics, National Cancer; Institute, Bethesda, MD, USA. granovsm@epndce.nci.nih.gov; PURPOSE: To describe the spectrum of malignancies in human immunodeficiency virus (HIV)-infected children and the clinical outcome of patients with these tumors. METHODS: We retrospectively surveyed the Children s Cancer Group (CCG) and the National Cancer Institute (NCI) for cases of cancer that occurred between July
Prospective randomized trial of two dose levels of interferon alfa with zidovudine for the treatment of Kaposi's sarcoma associated with human immunodeficiency virus infection: a Canadian HIV Clinical Trials Network study.: J Clin Oncol. 1998 May;16(5):1736-42. Unique Identifier : AIDSLINE MED/98246298; Shepherd FA; Beaulieu R; Gelmon K; Thuot CA; Sawka C; Read S; Singer J; Department of Medicine of the Toronto Hospital, Canada.; fshepherd@torhosp.toronto.on.ca; PURPOSE: Interferon alfa alone has shown antitumor activity against Kaposi s sarcoma (KS), and phase I and II clinical trials showed that interferon and zidovudine could be administered safely to patients with human immunodeficiency virus HIV)-associated KS. These observations led to our trial of zidovudine with two d
World Health Organization. Guidelines for counselling people about Human Immunodeficiency Virus [letter]: J Palliat Care. 1998 Spring;14(1):55. Unique Identifier : AIDSLINE MED/98236629; Bayes R
Striving for balance: palliative care patients' experiences of making everyday choices.: J Palliat Care. 1998 Spring;14(1):7-17. Unique Identifier : AIDSLINE MED/98236621; Bottorff JL; Steele R; Davies B; Garossino C; Porterfield P; Shaw M; School of Nursing, University of British Columbia, Vancouver, Canada.; A fundamental principle of palliative care is the provision of patient-centred care, an approach explicitly based on the patient s perspective. Although much attention has been given to determining patients preferences for involvement in medical decisions, choices related to personal and nursing care routines have be
T-cells and HLA-class II expression in the large intestine of infants in the early postnatal period.: J Pediatr Gastroenterol Nutr. 1998 Apr;26(4):422-8. Unique Identifier : AIDSLINE MED/98211867; Ormala T; Rintala R; Savilahti E; Department of Pediatrics, Kuopio University Hospital, Finland.; BACKGROUND: There is only limited knowledge of the development of the immune responses of the gut in very young infants after exposure to bacterial and food antigens at birth. METHODS: In this study, 49 large intestinal biopsy specimens, which were judged to have normal morphology, were taken from 49 young infants. El
Nutrition and the client with AIDS.: J Pract Nurs. 1998 Mar;48(1):16-25; quiz 26-8. Unique Identifier : AIDSLINE MED/98235059; Davidhizar R; Dunn C; The nutritional problems that go along with HIV infection and AIDS are significant and in fact contribute to death. Nutrition not only affects overall health but one s ability to respond to therapies and quality of life. Malnutrition and wasting syndrome result from compromised nutritional status. Early detection an
Membrane-induced alterations in HIV-1 Gag and matrix protein-protein interactions.: J Mol Biol. 1998 Mar 27;277(2):161-9. Unique Identifier : AIDSLINE MED/98181018; Scarlata S; Ehrlich LS; Carter CA; Department of Physiology and Biophysics, S.U.N.Y. Stony Brook, NY; 11794, USA.; The matrix (MA) domain of human immunodeficiency virus type 1 HIV-1) contains sequences that direct association with the nucleus at early times in the virus replication cycle and with the plasma membrane at late times in the cycle. Localization to these sites is critical for functions related to the establishment of t
Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation.: J Mol Biol. 1998 Mar 27;277(2):179-97. Unique Identifier : AIDSLINE MED/98181020; Wu-Baer F; Lane WS; Gaynor RB; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas, TX 75235-8594, USA.; The transactivator protein Tat stimulates transcriptional elongation from the HIV-1 LTR. One mechanism by which Tat increases HIV-1 transcription is by interacting with RNA polymerase II and TFIIH to increase phosphorylation of the polymerase C-terminal domain. Recent studies indicate that specific elongation factors
CIS elements and trans-acting factors required for minus strand DNA transfer during reverse transcription of the genomic RNA of murine leukemia virus.: J Mol Biol. 1998 Mar 27;277(2):225-35. Unique Identifier : AIDSLINE MED/98181023; Allain B; Rascle JB; de Rocquigny H; Roques B; Darlix JL; Ecole Normale Superieure de Lyon, 46 allee d'Italie, Lyon, 69364,; France.; During reverse transcription of the retroviral genomic RNA, two obligatory DNA strand transfers take place to synthesize the complete proviral DNA with two LTRs. We have previously shown that using an in vitro system made up of two viral RNAs mimicking the 5 and 3 regions of the retroviral genome, both nucleocapsid
Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistance-conferring mutations in interactions with nucleoside analog triphosphates.: J Mol Biol. 1998 Mar 27;277(2):237-47. Unique Identifier : AIDSLINE MED/98181024; Quan Y; Gu Z; Li X; Liang C; Parniak MA; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.; Resistance of HIV-1 reverse transcriptase (RT) to nucleoside analogs (e.g. AZT , ddC and 3TC ) is conferred by variou
Evolutionary rate and genetic heterogeneity of human T-cell lymphotropic virus type II (HTLV-II) using isolates from European injecting drug users.: J Mol Evol. 1998 May;46(5):602-11. Unique Identifier : AIDSLINE MED/98213688; Salemi M; Vandamme AM; Gradozzi C; Van Laethem K; Cattaneo E; Taylor G; Casoli C; Goubau P; Desmyter J; Bertazzoni U; Rega Institute for Medical Research and University Hospitals,; Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000; Leuven, Belgium. marco.salemi@uz.kuleuven.ac.be; Seven new Italian and two new British HTLV-II isolates were obtained from injecting drug users and the entire long terminal repeat (LTR) region was sequenced. Restriction analysis showed that all the Italian isolates are of the IIb subtype, whereas the British isolates are of the IIa subtype. To understand whether the
Abstinence and safer sex HIV risk-reduction interventions for African American adolescents: a randomized controlled trial [see comments]: JAMA. 1998 May 20;279(19):1529-36. Unique Identifier : AIDSLINE MED/98266933; Jemmott JB 3rd; Jemmott LS; Fong GT; Department of Psychology, Princeton University, NJ 08544-1010, USA.; jemmott@princeton.edu; CONTEXT: African American adolescents are at high risk of contracting sexually transmitted infection with human immunodeficiency virus (HIV), but which behavioral interventions to reduce risk are most effective and who should conduct them is not known. OBJECTIVE: To evaluate the effects of abstinence and safer-sex HIV
Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects.: JAMA. 1998 May 20;279(19):1554-9. Unique Identifier : AIDSLINE MED/98266937; Wistuba II; Behrens C; Milchgrub S; Virmani AK; Jagirdar J; Thomas B; Ioachim HL; Litzky LA; Brambilla EM; Minna JD; Gazdar AF; Hamon Center for Therapeutic Oncology Research, University of Texas; Southwestern Medical Center, Dallas 75235-8593, USA.; CONTEXT: Human immunodeficiency virus (HIV) infection has been associated with an increasing incidence of malignancy, and HIV-infected persons have an increased incidence of primary lung carcinoma compared with the general population. OBJECTIVE: To investigate the molecular changes present in HIV-associated lung tumor
Preventing sexually transmitted infections among adolescents: a clash of ideology and science [editorial; comment]: JAMA. 1998 May 20;279(19):1574-5. Unique Identifier : AIDSLINE MED/98266941; DiClemente RJ
[Hairy leukoplakia in immunodeficiency not due to HIV (letter; comment)]: Med Clin (Barc). 1998 Feb 28;110(7):279. Unique Identifier : AIDSLINE MED/98224056; Aneiros Cachaza J; Fernandez Feijoo MV; Carvia Ponsaille R
The Swedish HIV epidemics seen in the rear view: small "nuclear groups" are responsible for the transmission in the country]: Lakartidningen. 1998 Apr 8;95(15):1628-9. Unique Identifier : AIDSLINE MED/98261833; Giesecke J
[A HIV epidemics threatens Asia]: Lakartidningen. 1998 Apr 8;95(15):1682-3. Unique Identifier : AIDSLINE MED/98261849; Christenson B; Lundbergh P; Smittskyddsenheten, Karolinska sjukhuset, Stockholm.
[HIV in Africa is transmitted with varying intensity]: Lakartidningen. 1998 Apr 8;95(15):1684. Unique Identifier : AIDSLINE MED/98261850; Christenson B; Lundbergh P; Smittskyddsenheten, Karolinska sjukhuset, Stockholm.
Undefined CD4 lymphocytopenia without clinical complications. A report of two cases.: Panminerva Med. 1998 Mar;40(1):69-71. Unique Identifier : AIDSLINE MED/98234844; Cascio G; Massobrio AM; Cascio B; Anania A; Department of Internal Medicine, University of Turin, Italy.; A form of idiopathic CD4 lymphocytopenia (ICL) has been recently described. Its diagnostic criteria have been defined by the Centers for Disease Control (CDC), Atlanta. Associations of ICL with hepatitis C infection have been reported, while some ICL patients have presented abnormalities partly similar to those observ
Imported tropical diseases in subjects with HIV infection.: Panminerva Med. 1998 Mar;40(1):72-4. Unique Identifier : AIDSLINE MED/98234845; Manfredi R; Mastroianni A; Coronado OV; Chiodo F; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; The authors report a case of Plasmodium falciparum malaria and a case of lymphatic filariasis caused by Brugia malayi, imported by HIV-infected patients during trips in endemic countries. The clinical and laboratory picture, as well as treatment response of imported malaria and filariasis did not differ significantly
Inhibition of polyadenylation by stable RNA secondary structure.: Nucleic Acids Res. 1998 Apr 15;26(8):1870-6. Unique Identifier : AIDSLINE MED/98186825; Klasens BI; Das AT; Berkhout B; Department of Human Retrovirology, Academic Medical Center, University; of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, PO Box 22700, 1100; DE Amsterdam, The Netherlands.; The presence of a polyadenylation signal in the repeat (R) region of the HIV-1 genome, which is located at both the 5 and 3 ends of the viral transcripts, requires differential regulation of polyadenylation. The HIV-1 poly(A) site can fold in a stable stem-loop structure that is well-conserved among different human
Mismatched nucleotides may facilitate expansion of trinucleotide repeats in genetic diseases.: Nucleic Acids Res. 1998 Apr 15;26(8):1980-4. Unique Identifier : AIDSLINE MED/98186839; Nakayabu M; Miwa S; Suzuki M; Izuta S; Sobue G; Yoshida S; Department of Neurology and Laboratory of Cancer Cell Biology,; Institute of Disease Mechanism and Control, Nagoya University School; of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.; We have studied the contribution of mismatch sequences to the trinucleotide repeat expansion that causes hereditary diseases. Using an oligonucleotide duplex, (CAG)5/(CTG)5, as a template-primer, DNA synthesis was carried out using either Escherichia coli DNA polymerase I (Klenow fragment) or human immunodeficiency vi
NMR evidence for a base triple in the HIV-2 TAR C-G.C+ mutant-argininamide complex.: Nucleic Acids Res. 1998 Apr 15;26(8):1991-5. Unique Identifier : AIDSLINE MED/98186841; Brodsky AS; Erlacher HA; Williamson JR; MIT Department of Chemistry, Building 56-546, Cambridge, MA 02139,; USA.; Formation of a specific complex between the HIV Tat protein and the small RNA element TAR is critical for activation of viral transcription. A model complex for this interaction composed of HIV-2 TAR and the amide derivative of arginine has been developed to study how Tat and TAR interact specifically. We have previou
The association between cryptococcal variety and immunocompetent and immunocompromised hosts.: Pharmacotherapy. 1998 Mar-Apr;18(2):255-64. Unique Identifier : AIDSLINE MED/98204705; Peachey PR; Gubbins PO; Martin RE; Arkansas Poison Control/Drug Information Center, Little Rock, USA.; The varieties of Cryptococcus neoformans serotypes are neoformans and gattii. Data suggest an association between cryptococcal variety and host immune status. In addition, the two varieties differ in their epidemiology and pathogenicity. Furthermore, symptoms, outcome, and response of cryptococcosis to antifungal ther
Age-related macular degeneration. Can we stem this worldwide public health crisis?: Postgrad Med. 1998 May;103(5):153-6, 161-4. Unique Identifier : AIDSLINE MED/98253217; Starr CE; Guyer DR; Yannuzzi LA; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston,; USA.; Age-related macular degeneration, the leading cause of legal blindness in people over age 60 worldwide, represents a public health crisis that deserves the attention and understanding of all physicians. The dry form of the disease is more common than the wet, but the wet form causes the most severe vision loss. Other
Outpatient management of HIV-infected adults. The varied challenges for primary care.: Postgrad Med. 1998 May;103(5):219-28. Unique Identifier : AIDSLINE MED/98253221; Myers RA Jr; Inpatient HIV Service, Maricopa Medical Center, Phoenix, AZ 85010,; USA. ramyers95@aol.com; Care of persons infected with HIV presents many challenges to primary care physicians. In addition to keeping current on the rapidly advancing medical aspects of the disease, physicians also must be prepared to recognize the complex psychosocial issues that confront their patients. In this article, Dr Myers reviews es
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4831-6. Unique Identifier : AIDSLINE MED/98226727; Lubkowski J; Yang F; Alexandratos J; Wlodawer A; Zhao H; Burke TR Jr; Neamati N; Pommier Y; Merkel G; Skalka AM; Macromolecular Structure Laboratory, Advanced BioScience; Laboratories-Basic Research Program, National Cancer; Institute-Frederick Cancer Research and Development Center, Frederick,; MD 21702, USA.; The x-ray structures of an inhibitor complex of the catalytic core domain of avian sarcoma virus integrase (ASV IN) were solved at 1.9- to 2.0-A resolution at two pH values, with and without Mn2+ cations. This inhibitor (Y-3), originally identified in a screen for inhibitors of the catalytic activity of HIV type 1 int
CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5205-10. Unique Identifier : AIDSLINE MED/98226793; Kornbluth RS; Kee K; Richman DD; Department of Medicine, University of California, San Diego, and; Department of Veterans Affairs Medical Center, La Jolla, CA 92093,; USA. rkornbluth@ucsd.edu; beta-chemokines play an important role in the development of immunologic reactions. Macrophages are major beta-chemokine-producing cells during T-cell directed, delayed-type hypersensitivity reactions in tissues, and have been reported to be important producers of beta-chemokines in the lymph nodes of HIV-1-infected i
Generation of CD8 suppressor factor and beta chemokines, induced by xenogeneic immunization, in the prevention of simian immunodeficiency virus infection in macaques.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5223-8. Unique Identifier : AIDSLINE MED/98226796; Wang Y; Tao L; Mitchell E; Bogers WM; Doyle C; Bravery CA; Bergmeier LA; Kelly CG; Heeney JL; Lehner T; Department of Immunology, United Medical and Dental Schools of Guy's; and St. Thomas' Hospitals, London SE1 9RT, United Kingdom.; Previous xenogeneic immunization experiments in rhesus macaques with simian immunodeficiency virus (SIV) grown in human CD4(+) T cells consistently elicited protection from challenge with live SIV. However, the mechanism of protection has not been established. We present evidence that xenogeneic immunization induced s
The CCR5 receptor acts as an alloantigen in CCR5Delta32 homozygous individuals: identification of chemokineand HIV-1-blocking human antibodies.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5241-5. Unique Identifier : AIDSLINE MED/98226799; Ditzel HJ; Rosenkilde MM; Garred P; Wang M; Koefoed K; Pedersen C; Burton DR; Schwartz TW; Department of Clinical Immunology, Copenhagen University Hospital,; Rigshospitalet, DK-2200 Copenhagen, Denmark. hditzel@scripps.edu; The chemokine receptor CCR5 is the major coreceptor for infection by macrophage-tropic R5 HIV-1. A 32-bp deletion in the gene coding for CCR5 (CCR5Delta32) occurs with a frequency of 10% in the Caucasian population and results in a receptor protein that is truncated and not expressed at the cell surface. CCR5Delta32 h
HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator.: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5281-6. Unique Identifier : AIDSLINE MED/98226806; Felzien LK; Woffendin C; Hottiger MO; Subbramanian RA; Cohen EA; Nabel GJ; Departments of Internal Medicine and Biological Chemistry, Howard; Hughes Medical Institute, University of Michigan Medical Center, Ann; Arbor, MI 48109-0650, USA.; The accessory protein, Vpr, is a virion-associated protein that is required for HIV-1 replication in macrophages and regulates viral gene expression in T cells. Vpr causes arrest of cell cycle progression at G2/M, presumably through its effect on cyclin B1.Cdc2 activity. Here, we show that the ability of Vpr to activa
[The importance of HIV in the Spanish woman (editorial)]: Rev Clin Esp. 1998 Feb;198(2):55-6. Unique Identifier : AIDSLINE MED/98219627; Palacios S; Cifuentes I
[Primary adrenal failure and AIDS: report of 11 cases and review of the literature]: Rev Clin Esp. 1998 Feb;198(2):74-9. Unique Identifier : AIDSLINE MED/98219631; Baraia-Etxaburu Artetxe J; Astigarraga Aguirre B; Elorza Olabegova R; Teira Cobo R; Yoldi Arrieta A; Cisterna Cancer R; Bustamante Murga V; Santamaria Jauregui JM; Seccione de Enfermedades Infecciosas, Hospital de Basurto, Bilbao.; OBJECTIVE: To know the prevalence of adrenal insufficiency (AI) in our patients with acquired immunodeficiency syndrome (AIDS) and to compare the clinical manifestations with those reported in previous series in the literature. PATIENTS AND METHODS: Retrospective study with review of clinical records of patients with
[Acute pancreatitis and infection with the human immunodeficiency virus]: Rev Clin Esp. 1998 Mar;198(3):133-9. Unique Identifier : AIDSLINE MED/98247581; Sanchez Munoz LA; Ferrero Beneitez OL; Perez Boillos MJ; Munoz Sanchez J; Teira Cobo R; Baraia-Etxaburu J; Zubero Sulibarria Z; Santamaria Jauregui JM; Seccion de Enfermedades Infecciosas, Hospital de Basurto, Bilbao,; Vizcaya.; BACKGROUND: Retrospective study of the etiology and evolution of 40 episodes of acute pancreatitis in 28 patients infected with the human immunodeficiency virus (HIV). RESULTS: AIDS criteria were met by 89.3% of patients. The likely etiology was an opportunist infection in 32.5% of episodes, drug use in 22.5%, and bil
[Increase in transaminases in HIV infection. Toxic liver cell damage with trimethoprim/sulfamethoxazole administration in HIV infection]: Schweiz Rundsch Med Prax. 1998 Mar 4;87(10):361-2. Unique Identifier : AIDSLINE MED/98207455; Junghanss BG; Departement fur Innere Medizin, Kantonsspital Basel.
Improved humoral and cellular immune responses against the gp120 V3 loop of HIV-1 following genetic immunization with a chimeric DNA vaccine encoding the V3 inserted into the hepatitis B surface antigen.: Scand J Immunol. 1998 Apr;47(4):289-95. Unique Identifier : AIDSLINE MED/98260936; Fomsgaard A; Nielsen HV; Bryder K; Nielsen C; Machuca R; Bruun L; Hansen J; Buus S; Department of Virology, Statens Serum Institut, Copenhagen, Denmark.; The gp120-derived V3 loop of HIV-1 is involved in co-receptor interaction, it guides cell tropism, and contains an epitope for antibody neutralization. Thus, HIV-1 V3 is an attractive vaccine candidate. The V3 of the MN strain (MN V3) contains both B- and T-cell epitopes, including a known mouse H-2d-restricted cytoto
Blockade of B7-2, not B7-1, inhibits purified protein derivative-primed T-lymphocyte responses but fails to influence the proportion of Th1 versus Th2 subsets.: Scand J Immunol. 1998 Apr;47(4):355-62. Unique Identifier : AIDSLINE MED/98260944; Shortt J; Hart DN; Watson JD; Baird MA; Department of Pathology, Dunedin School of Medicine, New Zealand.; The ability to select for a cell-mediated response rather than antibody production following infection with intracellular mycobacteria, would be an advantage in preventing the occurrence of disease. Recent work suggests that the two members of the B7 family of costimulatory molecules, B7-1 and B7-2, may differentially
Genetic evaluation of suspected cases of transient HIV-1 infection of infants.: Science. 1998 May 15;280(5366):1073-7. Unique Identifier : AIDSLINE MED/98248614; Frenkel LM; Mullins JI; Learn GH; Manns-Arcuino L; Herring BL; Kalish ML; Steketee RW; Thea DM; Nichols JE; Liu SL; Harmache A; He X; Muthui D; Madan A; Hood L; Haase AT; Zupancic M; Staskus K; Wolinsky S; Krogstad P; Zhao J; Chen I; Koup R; Ho D; Roberts NJ Jr; et al; Department of Pediatrics, University of Rochester, Rochester, NY; 14642, USA. lfrenkel@u.washington.edu; Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants
Autoantibodies and common viral illnesses.: Semin Arthritis Rheum. 1998 Apr;27(5):263-71. Unique Identifier : AIDSLINE MED/98232423; Hansen KE; Arnason J; Bridges AJ; University of Wisconsin Hospital and Clinics, Madison 53792, USA.; OBJECTIVES: To review the literature about common autoantibodies produced in association with viral infection. METHODS: Medline review of the medical literature published in English. RESULTS: Common viral infections are often associated with low-titer, polyspecific autoantibodies. However, high-titer antinuclear antib
Toxoplasmosis.: Semin Roentgenol. 1998 Jan;33(1):81-5. Unique Identifier : AIDSLINE MED/98177334; Dunn IJ; Palmer PE; Department of Radiology, University of British Columbia, Vancouver,; Canada.
Telephone support groups for HIV-positive mothers whose children have died of AIDS.: Soc Work. 1998 May;43(3):279-85. Unique Identifier : AIDSLINE MED/98260238; Wiener LS; Pediatric HIV Psychosocial Support Program, National Cancer Institute,; National Institutes of Health, Bethesda, MD, USA.; wienerl@pbmac.nci.nih.gov
The high-risk sexual practices of crack-smoking sex workers recruited from the streets of three American cities. The Multicenter Crack Cocaine and HIV Infection Study Team.: Sex Transm Dis. 1998 Apr;25(4):187-93. Unique Identifier : AIDSLINE MED/98225908; Jones DL; Irwin KL; Inciardi J; Bowser B; Schilling R; Word C; Evans P; Faruque S; McCoy HV; Edlin BR; Department of Sociology, Emory University, Atlanta, Georgia.; BACKGROUND AND OBJECTIVES: Small ethnographic and clinic-based studies indicate that crack-smoking sex workers are at high risk for human immunodeficiency virus (HIV) and sexually transmitted diseases (STD). STUDY GOALS: To examine the prevalence of risky sexual behaviors and HIV and STD in a large sample of street-re
The value of workplace versus income in determining HIV status and other STDs among a sample of Spanish sex workers.: Sex Transm Dis. 1998 Apr;25(4):194-5. Unique Identifier : AIDSLINE MED/98225909; Estebanez P; Grant JC; London School of Hygiene & Tropical Medicine.
Clinico-epidemiologic features of granuloma inguinale in the era of acquired immune deficiency syndrome.: Sex Transm Dis. 1998 Apr;25(4):196-200. Unique Identifier : AIDSLINE MED/98225910; Jamkhedkar PP; Hira SK; Shroff HJ; Lanjewar DN; Department of Skin/STD, Sir J. J. Hospital, Mumbai, India.; BACKGROUND AND OBJECTIVES: Granuloma Inguinale (GI) is an endemic sexually transmitted disease (STD) in India . With increasing prevalence of human immunodeficiency virus (HIV) among patients with STD at a clinic in Mumbai, a study was conducted to determine clinico-epidemiologic fea
The acceptability of oral fluid testing for HIV antibodies. A pilot study in gay bars in a predominantly rural state.: Sex Transm Dis. 1998 Apr;25(4):211-5. Unique Identifier : AIDSLINE MED/98225912; Sy FS; Rhodes SD; Choi ST; Drociuk D; Laurent AA; Naccash RM; Kettinger LD; University of South Carolina School of Public Health, Columbia 29208,; USA.; BACKGROUND: One barrier for individuals desiring human immunodeficiency virus (HIV) antibody testing has been the lack of alternatives to blood HIV testing. Oral fluid HIV testing provides another testing option. OBJECTIVES: To evaluate the acceptability of oral fluid testing for HIV antibodies in a gay bar outreach s
Heterosexual intercourse in a French prison [letter]: Sex Transm Dis. 1998 Apr;25(4):217. Unique Identifier : AIDSLINE MED/98225913; Rotily M; Gore S; Weilandt C
[Kaposi sarcoma-associated Herpesvirus infection of dendritic cells in bone marrow in patients with myelomatosis]: Ugeskr Laeger. 1998 Apr 6;160(15):2264-5. Unique Identifier : AIDSLINE MED/98261899; Abildgaard N; Nielsen JL; Arhus Universitetshospital, Arhus Amtssygehus, medicinsk haematologisk; afdeling B.
[Providing patients with their diagnostic test results. A vignette study in general practice]: Ugeskr Laeger. 1998 Apr 20;160(17):2543-5. Unique Identifier : AIDSLINE MED/98261911; Nexoe J; Falk-Petersen HE; Klit S; Larsen NJ; Winthereik M; Odense Universitet, Specialeuddannelsen i Almen Medicin.; The communication of results of HIV tests and chest-X-rays because of persistent coughing are of particular interest because potential life-threatening disease may be disclosed. For HIV tests it is recommended that the result is communicated to the patient in the doctor s office face to face. In this questionnaire stu
[Role of Danish general practitioners in the prevention of AIDS]: Ugeskr Laeger. 1998 Apr 20;160(17):2546-50. Unique Identifier : AIDSLINE MED/98261912; Sandbaek A; Kragstrup J; Odense Universitet, Fagomr~adet og Forskningsenheden for Almen; Medicin.; The study describes Danish general practitioners perception of their own role and their actual behaviour in the prevention of HIV/AIDS. Data collection was carried out by questionnaire and prospective registration of consultations dealing with HIV/AIDS during a two-week period. The results showed that most of the GPs
The cells observed inside capsules of larvae in the course of experimental trichinellosis in mice.: Wiad Parazytol. 1997;43(3):251-6. Unique Identifier : AIDSLINE MED/98218372; Karmanska K; Houszka M; Widyma A; Stefaniak E; W. Stefanski Institute of Parasitology, Polish Academy of Science,; Wroclaw, Poland.; In the course of trichinellosis in mice the numerous cells inside larval capsules were observed. Beginning on 14 day post infection dpi) they were seen in about 7% of infected muscles fibers but at 21 dpi the percentage of capsules with the cells amounted to 77. In the next stage of infection the number of capsules co
Identification of potential CD8+ T-cell epitopes of the 19 kDa and AhpC proteins from Mycobacterium tuberculosis. No evidence for CD8+ T-cell priming against the identified peptides after DNA-vaccination of mice.: Vaccine. 1998 Apr;16(7):692-7. Unique Identifier : AIDSLINE MED/98223781; Erb KJ; Kirman J; Woodfield L; Wilson T; Collins DM; Watson JD; LeGros G; Malaghan Institute of Medical Research, Wellington, New Zealand.; Mycobacterium tuberculosis is one of the major killers among infectious agents. It is of great importance to develop an efficient vaccine against M. tuberculosis since the only available vaccine, M. bovis-BCG, has a low efficacy. Furthermore, the emergence of multi-drug-resistant M. tuberculosis strains makes it diffi
Apoptosis in asymptomatic HIV-1 seropositives immunized with HIV-1 env glycoprotein (gp160): effects of administration of Zidovudine in vivo and interleukin-2 in vitro.: Vaccine. 1998 Apr;16(7):715-21. Unique Identifier : AIDSLINE MED/98223784; Pierdominici M; Mollicone B; Ricci G; Oliva A; D'Offizi G; Giovannetti A; Aiuti F; Pandolfi F; University of Rome La Sapienza, Italy. pandolfi@axrma.uniroma1.it; In this paper we report the effects of VaxSyn (Protein Sciences Corp.) immunization on spontaneous apoptosis occurring in vitro after culture of PBMC in medium alone in 30 HIV-seropositive patients enrolled in a double-blind clinical trial that included three groups: treatment with VaxSyn,
Whole-killed gp120-depleted HIV-1 antigen in a murine model for prophylactic vaccination.: Vaccine. 1998 Apr;16(7):727-31. Unique Identifier : AIDSLINE MED/98223786; Lanza P; Moss RB; Giermakowska W; Hancock RB; Richieri SP; Theofa G; Jensen FC; Salk PL; Carlo DJ; Immune Response Corporation, Carlsbad, CA 92008, USA.; In this study, the effects were examined of dose and adjuvant of whole-killed gp120-depleted HIV-1 antigen on antibody and cytokine responses in a murine model. Immunization with increasing doses of inactivated HIV-1 antigen in Incomplete Freund s Adjuvant (IFA) resulted in increased production of IL-4 and IgG1 antibo
Early neuropsychological impairment in HIV-seropositive intravenous drug users: evidence from the Italian Multicentre Neuropsychological HIV Study.: Acta Psychiatr Scand. 1998 Feb;97(2):132-8. Unique Identifier : AIDSLINE MED/98177086; Starace F; Baldassarre C; Biancolilli V; Fea M; Serpelloni G; Bartoli L; Maj M; Department of Psychiatry, University of Naples, Italy.; The aim of the Italian Multicentre Neuropsychological HIV Study is to assess the prevalence and natural history of cognitive deficit in intravenous drug users (i.v.DUs) during the asymptomatic phase of HIV infection. The study is currently being conducted in four centres (Napoli, Benevento, Verona and Pavia) whose cat
Individualized strategies in the era of combination antiretroviral therapy.: J Am Board Fam Pract. 1998 Mar-Apr;11(2):158-64. Unique Identifier : AIDSLINE MED/98203836; Goldschmidt RH; Balano KB; Legg JJ; Dong BJ; Family Practice Residency Program, San Francisco General Hospital, CA; 94110, USA.
Put to sleep.: J Am Board Fam Pract. 1998 Mar-Apr;11(2):165. Unique Identifier : AIDSLINE MED/98203837; Magill MK; Department of Family and Preventive Medicine, University of Utah; School of Medicine, Salt Lake City 84132, USA.
Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma.: Am J Pathol. 1998 May;152(5):1187-97. Unique Identifier : AIDSLINE MED/98248302; Nagano H; Libby P; Taylor MK; Hasegawa S; Stinn JL; Becker G; Tilney NL; Mitchell RN; Department of Surgery, Brigham and Women's Hospital, Harvard Medical; School, Boston, Massachusetts 02115, USA.; This study evaluated the contribution of acute parenchymal rejection and interferon (IFN)-gamma to the development of graft arterial disease (GAD) in totally allogeneic murine cardiac transplants. BALB/c (H-2d) hearts were transplanted into wild-type C57BL/6 (B6, H-2b) or B6 IFN-gamma-deficient (GKO) recipient mice. A
Interleukin-12 promotes activation of effector cells that induce a severe destructive granulomatous form of murine experimental autoimmune thyroiditis.: Am J Pathol. 1998 May;152(5):1347-58. Unique Identifier : AIDSLINE MED/98248317; Braley-Mullen H; Sharp GC; Tang H; Chen K; Kyriakos M; Bickel JT; Department of Internal Medicine, University of Missouri-Columbia; School of Medicine, 65212, USA. helen_mullen@muccmail.missouri.edu; Granulomatous inflammatory lesions are a major histopathological feature of a wide spectrum of human infectious and autoimmune diseases. Experimental autoimmune thyroiditis (EAT) with granulomatous histopathological features can be induced by mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MT
IGF-I alters lymphocyte survival and regeneration in thymus and spleen after dexamethasone treatment.: Am J Physiol. 1998 Apr;274(4 Pt 2):R912-20. Unique Identifier : AIDSLINE MED/98236865; Hinton PS; Peterson CA; Dahly EM; Ney DM; Department of Nutritional Sciences, University of Wisconsin-Madison; 53706, USA.; Insulin-like growth factor I (IGF-I) is a growth factor for the immune system, increasing lymphocyte number and function via greater lymphocyte generation and/or survival. We investigated the effects of IGF-I on lymphocyte survival and regeneration in the thymus and spleen after dexamethasone (Dex) treatment in rats m
Cross-national comparisons of sexual behavior surveys--methodological difficulties and lessons for prevention [editorial]: Am J Public Health. 1998 May;88(5):730-1. Unique Identifier : AIDSLINE MED/98246825; Spira A; Bajos N; Giami A; Michaels S
Modification of the clinical course of intestinal microsporidiosis in acquired immunodeficiency syndrome patients by immune status and anti-human immunodeficiency virus therapy.: Am J Trop Med Hyg. 1998 May;58(5):555-8. Unique Identifier : AIDSLINE MED/98258387; Conteas CN; Berlin OG; Speck CE; Pandhumas SS; Lariviere MJ; Fu C; Division of Gastroenterology, Southern California Permanente Medical; Group, Los Angeles 90027, USA.; The clinical course of 37 Enterocytozoon bieneusi-infected acquired immunodeficiency syndrome patients with diarrhea was studied. Parasite clearance was seen in 15 patients (40.5%). Clearance of E. bieneusi resulted in a 25-100% reduction in episodes of diarrhea, suggesting that microsporidia are true pathogens. Univa
Examination of the prevalence and seasonal variation of intestinal microsporidiosis in the stools of persons with chronic diarrhea and human immunodeficiency virus infection.: Am J Trop Med Hyg. 1998 May;58(5):559-61. Unique Identifier : AIDSLINE MED/98258388; Conteas CN; Berlin OG; Lariviere MJ; Pandhumas SS; Speck CE; Porschen R; Nakaya T; Division of Gastroenterology, Southern California Permanente Medical; Group, Los Angeles 90027, USA.; The epidemiology of human microsporidiosis is poorly understood and environmental factors affecting transmission of the organism have not been fully elucidated. Temporal variation in the prevalence of microsporidia in the stool of patients with human immunodeficiency v
Evaluation of the protective efficacy of a recombinant dengue envelope B domain fusion protein against dengue 2 virus infection in mice.: Am J Trop Med Hyg. 1998 May;58(5):655-62. Unique Identifier : AIDSLINE MED/98258404; Simmons M; Nelson WM; Wu SJ; Hayes CG; Naval Medical