Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection.

Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection.

J Vet Med Sci. 1997 Nov;59(11):1049-51. Unique Identifier : AIDSLINE MED/98073989
Mizuno T; Momoi Y; Endo Y; Nishimura Y; Goto Y; Ohno K; Watari T; Tsujimoto H; Hasegawa A; Department of Veterinary Internal Medicine, Faculty of Agriculture,; University of Tokyo, Japan.

Abstract: Feline immunodeficiency virus (FIV)-infected cells have been shown to undergo apoptosis by treatment with tumor necrosis factor alpha (TNF-alpha). This study detected a soluble factor which enhanced the apoptosis induced by TNF-alpha treatment. The sensitivity to TNF-alpha in the induction of apoptosis in a feline fibroblastoid cell line (CRFK) cells was significantly enhanced when the culture supernatant of FIV-infected CRFK cells or plasma samples from FIV-infected cats was added to the culture. These findings suggested that FIV infection induces production of a soluble factor which enhances CRFK cells sensitivity to TNF-alpha induction of apoptosis both in vitro and in vivo. This factor may contribute to the loss of lymphocytes in cats infected with FIV.

Keywords: *Apoptosis/PHYSIOLOGY *Immunodeficiency Virus, Feline/PHYSIOLOGY
980430
M9841853

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