Dynamics of fine T-cell subsets during HIV disease and after thymic ablation by mediastinal irradiation.

Dynamics of fine T-cell subsets during HIV disease and after thymic ablation by mediastinal irradiation.

Semin Immunol. 1997 Dec;9(6):389-96. Unique Identifier : AIDSLINE MED/98070939
Roederer M; De Rosa SC; Watanabe N; Herzenberg LA; Department of Genetics, Stanford University, Stanford, CA 94305-5125,; USA.

Abstract: The T-cell compartment is considerably more complex than just CD4 and CD8 T cells. Indeed, we can identify dozens of functionally and phenotypically distinct subsets within the peripheral blood of humans. These subsets are differentially affected in diseases which may underly some of the functional defects attributable to the disease. In HIV disease, all thymic-derived T-cell populations are gradually lost at identical rates during late-stage disease progression, while unusual, perhaps extrathymically-derived T cells expand. This expansion may reflect an attempt on the part of the immune system to compensate for the significant insult of HIV infection to the host: the abrogation of normal thymopoiesis and T-cell homeostasis. Copyright 1997 Academic Press Limited.

Keywords: *HIV Infections/IMMUNOLOGY *T-Lymphocyte Subsets/IMMUNOLOGY
980430
M9841830

ÆGIS is made possible through unrestricted grants from Boehringer Ingelheim, iMetrikus, Inc., John M. Lloyd Foundation, the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 1998. This material is designed to support, not replace, the relationship that exists between you and your doctor.

ÆGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 2003. AEGiS. All materials appearing on ÆGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of ÆGiS, or the party credited as the provider of the content.