The effect of exercise on lymphocyte redistribution and leucocyte function in asymptomatic HIV-infected subjects.

The effect of exercise on lymphocyte redistribution and leucocyte function in asymptomatic HIV-infected subjects.

Brain Behav Immun. 1997 Sep;11(3):217-27. Unique Identifier : AIDSLINE MED/98086452
Phillips EJ; Ottaway CA; Freedman J; Kardish M; Li J; Singer W; Fong IW; St. Michael's Hospital, Department of Medicine, University of Toronto,; Canada.

Abstract: This study was undertaken to examine the responsiveness of circulating leucocyte and lymphocyte populations to the physiological demands of exercise in asymptomatic HIV-infected subjects with CD4+ counts greater than 500/microliter. Thirteen subjects infected with HIV and 14 control subjects underwent 20 min of defined moderate exercise at estimated 65% of their maximal ventilatory capacity on a bicycle ergometer. Blood samples were obtained for serum cortisol, norepinephrine, lymphocyte subsets (CD4, CD8, CD19, CD16-CD56), and phagocytic function at rest immediately after exercise and 20 min following the cessation of the exercise. The HIV-infected subjects had increased circulating concentrations of CD8 cells (p = .007) and CD16-CD56+ NK cells (p = .02) in response to the exercise, whereas the control group did not. There was a greater increase in monocyte respiratory burst activity following recovery from exercise in the control subjects (p = .016) but not in the HIV-infected subjects. The control subjects experienced an increase in serum cortisol in response to the exercise (p = 006), but the HIV-infected subjects did not. Our results show that the changes in the distribution and function of circulating leucocytes and adrenal neuroendocrine responses to moderate exercise differ in asymptomatic HIV-infected and control subjects.

Keywords: *Exercise/PHYSIOLOGY *HIV Seropositivity/IMMUNOLOGY *HIV Seropositivity/PHYSIOPATHOLOGY *Leukocytes/PHYSIOLOGY *Lymphocytes/PHYSIOLOGY
980430
M9841824

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