Inhibition of interleukin-6-induced human immunodeficiency virus type 1 expression by anti-gp130 monoclonal antibody.

Inhibition of interleukin-6-induced human immunodeficiency virus type 1 expression by anti-gp130 monoclonal antibody.

Biochem Mol Biol Int. 1997 Nov;43(4):733-40. Unique Identifier : AIDSLINE MED/98046543
Okamoto M; Yasukawa K; Katsuura K; Baba M; Division of Human Retroviruses, Faculty of Medicine, Kagoshima; University, Japan.

Abstract: Interleukin 6 (IL-6) has been reported to upregulate the expression of human immunodeficiency virus type 1 (HIV-1) in infected monocyte/macrophages. Since IL-6 signal is transduced through the membrane glycoprotein gp130, we investigated the inhibitory effect of anti-gp130 monoclonal antibody (mAb) on IL-6-induced viral expression in monocytic cell lines latently infected with HIV-1. IL-6 significantly induced the expression of HIV-1 in U1 cells, whereas it had no effect in OM-10.1 cells. Flow cytometric analysis revealed that U1 but not OM-10.1 cells expressed gp130 on their surface. The anti-gp130 mAb could inhibit IL-6-induced HIV-1 expression in U1 cells in a dose dependent fashion. These results suggest that blocking the gp130 signal transduction may have therapeutic potential for the treatment of HIV-1 infection.

Keywords: *Antibodies, Monoclonal/PHARMACOLOGY *Antigens, CD/IMMUNOLOGY *HIV-1/IMMUNOLOGY *Interleukin-6/PHARMACOLOGY *Membrane Glycoproteins/IMMUNOLOGY *Monocytes/IMMUNOLOGY *Monocytes/VIROLOGY
980430
M9841815

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