Adenovirus-induced liver necrosis in a case of AIDS.

Adenovirus-induced liver necrosis in a case of AIDS.

Virchows Arch. 1997 Dec;431(6):469-72. Unique Identifier : AIDSLINE MED/98090615
Dombrowski F; Eis-Hubinger AM; Ackermann T; Blumel J; Spengler U; Pfeifer U; Pathologisches Institut, Universitat Bonn, Germany.

Abstract: Adenovirus-induced liver necrosis is rare. Because the era of AIDS (acquired immunodeficiency syndrome) this entity was seen predominantly in infants suffering from inborn immunodeficiency syndromes or from iatrogenic immunosuppression because of bone marrow or liver transplantation. Here, we report a case of a 30-year-old woman with AIDS who developed fever and rapidly progressing liver failure. A frozen section from a needle biopsy of the liver allowed a quick diagnosis of viral liver necrosis. The light-microscopic and electron microscopic aspects were typical of adenovirus infection and should be known to the surgical pathologist. The diagnosis was confirmed by immunohistochemistry and DNA hybridization analysis.

Keywords: *Acquired Immunodeficiency Syndrome/COMPLICATIONS *Adenoviridae Infections/COMPLICATIONS *Liver/PATHOLOGY
980430
M9841811

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