[Importance of measurement of plasma viral load for the therapeutic follow-up of children infected with HIV-1. Study of its evolution according to modifications of treatment in 55 children]
Bull Acad Natl Med. 1997 Jun-Jul;181(6):1163-74; discussion 1174-6. Unique Identifier : AIDSLINE MED/98064376 Lasfargues G; Courpotin C; Nicolas JC; Dollfus C; Service d'hematologie et d'oncologie pediatrique, Hopital; Armand-Trousseau, Paris.
Abstract:
Since 1987 we started to treat all vertically HIV-1 infected newborns by an antiretroviral therapy as soon as the diagnosis was confirmed. From the study of 55 HIV-1 infected children followed at Armand Trousseau Hospital (Paris, France) we retrospectively evaluated the use of the plasma viral load as a marker of the treatment efficiency. This parameter and CD4 counts were measured the day of any modification in antiviral therapy Day 0), 1 and 3 months later (M1 and M3) and every 3 months as long as possible. In the 3 groups of treatment modifications a decrease in plasma viral load was observed. A statistically significant increase in CD4 counts was only observed in the group treated with the association of 2 nucleoside analogues and 1 proteinase inhibitor. This group demonstrated the most important decrease in plasma viral load (> 0.7 log 10 Eq Cop/ml). This leads us to propose to the "ANRS" a protocol study for the treatment of all vertically HIV-1 infected children by the association of 3 nucleoside analogues and 1 proteinase inhibitor as early as 8 weeks post natal when the HIV infection is confirmed.
Keywords: *Acquired Immunodeficiency Syndrome/DRUG THERAPY *HIV-1 *Viral Load 980430
M9841785
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