Cytokines and anaemia in human immunodeficiency virus infection.

Cytokines and anaemia in human immunodeficiency virus infection.

Cytokines Cell Mol Ther. 1997 Sep;3(3):179-86. Unique Identifier : AIDSLINE MED/98088415
Means RT Jr; Hematology/Oncology Division, University of Cincinnati College of; Medicine, OH, USA. rmeansjr@mail.one.net

Abstract: The anaemia that is a common complication of human immunodeficiency virus (HIV) infection bears many similarities to the anaemia of chronic disease. These similarities include an impaired erythropoietin (EPO) response to anaemia, reduced concentrations of marrow progenitors giving rise to erythroid colonies, abnormalities of reticuloendothelial iron metabolism, and correction of anaemia with recombinant human EPO. A model has been developed in which the pathophysiologic processes producing the anaemia of chronic disease may be attributed to actions of the cytokines that mediate the immune response, such as interleukin-1, tumor necrosis factor and the interferons. These cytokines are also implicated in HIV-related anaemia. In this review, the applicability of this cytokine-mediated anaemia model to the anaemia of HIV infection is explored.

Keywords: *Anemia/ETIOLOGY *Cytokines/PHYSIOLOGY *HIV Infections/COMPLICATIONS
980430
M9841768

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