1998

DNA immunization with a bovine rotavirus VP4 gene induces a Th1-like immune response in mice.: Viral Immunol. 1997;10(3):117-27. Unique Identifier : AIDSLINE MED/98003019; Suradhat S; Yoo D; Babiuk LA; Griebel P; Baca-Estrada ME; Department of Veterinary Microbiology, Western College of Veterinary; Medicine, University of Saskatchewan, Saskatoon, Canada.; Immunization with naked plasmid DNA effectively induces both humoral and cell-mediated immunity to vaccine antigens and can confer protection against numerous infectious diseases. To explore the potential use of DNA immunization to induce rotavirus-specific immune responses, we used plasmid DNA encoding the VP4 gene o
Detection of antibodies to a recombinant gag protein derived from human endogenous retrovirus clone 4-1 in autoimmune diseases.: Viral Immunol. 1997;10(3):137-47. Unique Identifier : AIDSLINE MED/98003021; Hishikawa T; Ogasawara H; Kaneko H; Shirasawa T; Matsuura Y; Sekigawa I; Takasaki Y; Hashimoto H; Hirose S; Handa S; Nagasawa R; Maruyama N; Department of Internal Medicine, Juntendo University, School of; Medicine, Tokyo, Japan.; To investigate whether human endogenous retroviruses (HERV) contribute to autoimmune diseases, we prepared a recombinant p30gag protein derived from clone 4-1 of the HERV family, using a baculovirus-vector system. This p30gag protein (CA41B) was approximately 30 kDa, as expected, and reacted with antibodies for p30gag
Kinetics study of human retrovirus antigens expression in T lymphocytic cell lines by indirect immunofluorescence assay.: Viral Immunol. 1997;10(3):149-57. Unique Identifier : AIDSLINE MED/98003022; Gallego S; Recalde A; Gastaldello R; Isa M; Nates S; Medeot S; Institute of Virology Dr. J.M. Vanella, School of Medical Sciences,; National University of Cordoba, Argentina.; Indirect immunofluorescence assay (IFA) is a well-accepted assay for the confirmation of human retrovirus infection. Fluctuations in HIV-1 antigen expression in infected E-B2 cells depending on several factors have been reported. Cells kept in log phase expressed the highest levels of viral antigen. Thus, we studied t
HIV transmission by transplantation of allograft skin: a review of the literature [letter]: Burns. 1997 Aug;23(5):460. Unique Identifier : AIDSLINE MED/98088359; Van Baare J; Mackie DP; Middelkoop E
Induction of neutralizing antibodies against HTLV-I envelope proteins after combined genetic and protein immunizations in mice.: DNA Cell Biol. 1997 Dec;16(12):1439-48. Unique Identifier : AIDSLINE MED/98089068; Grange MP; Armand MA; Audoly G; Thollot D; Desgranges C; INSERM U271, Lyon, France.; Direct DNA inoculation can induce both protective humoral and cellular responses against several viruses. The HTLV-I envelope glycoproteins are the major antigens recognized by sera of HTLV-I infected patients that generate neutralizing immune responses in vitro and in vivo. We compared immune responses elicited after
[Many infectious diseases threaten people's health worldwide. The current picture of AIDS]: TVZ. 1997 Sep 6;107(15-16):442-7. Unique Identifier : AIDSLINE MED/98106659; van der Kruk T; Tesselaar J; Academisch Medisch Centrum, Amsterdam.
[AIDS (news)]: TVZ. 1997 Sep 6;107(15-16):461. Unique Identifier : AIDSLINE MED/98106663
Applications of site-specific chemical modification in the manufacture of biopharmaceuticals: I. An overview.: Biotechnol Appl Biochem. 1997 Dec;26 ( Pt 3):143-51. Unique Identifier : AIDSLINE MED/98089622; Lundblad RL; Bradshaw RA; Baxter Biotech-Hyland Division, Duarte, CA 91010, USA.; The chemical modification of proteins has long been a useful approach to elucidating structure-function relationships. Recently, these same chemistries have been finding application in the preparation of proteins for both diagnostic and therapeutic use. These applications include alterations to introduce new propertie
Retrieval of DNA sequences present at an extremely low frequency.: Biotechniques. 1997 Dec;23(6):1104-9. Unique Identifier : AIDSLINE MED/98083381; Zafiropoulos A; Hatzidakis G; Mavrogiannis L; Klinakis A; Kandilogiannaki M; Krambovitis E; Institute of Molecular Biology and Biotechnology, Heraklion, Crete,; Greece.; We describe a method for retrieving sequences with one or two point mutations of a given target sequence, which are present in a DNA population at a frequency of 1 in 466 x 10(3) and 1 in 28 x 10(3) molecules, respectively. By stringent hybridization to a stable, chemically immobilized probe, a large excess of unrelat
Affinity purification of RNA: sequence-specific capture by nonionic morpholino probes.: Biotechniques. 1997 Dec;23(6):1116-21. Unique Identifier : AIDSLINE MED/98083383; Wages JM Jr; Wages GM; Matthews P; Weller D; Summerton J; AntiVirals, Corvallis, OR, USA.; Nucleic acid isolation for amplification-based diagnostics requires techniques that do not co-purify inhibitors of DNA polymerases. Also, other requirements for an ideal sample preparation technology include ease of use, capability for automation, high recovery and the use of nontoxic reagents. Affinity purification t
Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector.: Hum Gene Ther. 1997 Oct 10;8(15):1797-806. Unique Identifier : AIDSLINE MED/98019061; Svensson EC; Black HB; Dugger DL; Tripathy SK; Goldwasser E; Hao Z; Chu L; Leiden JM; Department of Medicine, University of Chicago, IL 60637, USA.; Erythropoietin (Epo)-responsive anemia is a debilitating complication of chronic renal failure and human immunodeficiency virus (HIV) infection that effects more than 150,000 Americans. Patients with Epo-responsive anemias are currently treated with repeated injections of recombinant human Epo. In the studies describe
Antitumor responses induced by transgenic expression of CD40 ligand.: Hum Gene Ther. 1997 Nov 1;8(16):1935-43. Unique Identifier : AIDSLINE MED/98043307; Grossmann ME; Brown MP; Brenner MK; Division of Bone Marrow Transplantation and Cell and Gene Therapy; Program, St. Jude Children's Research Hospital, Memphis, TN 38105,; USA.; Because CD40 ligand (CD40L) is a co-stimulator molecule for multiple components of the immune response, we wanted to determine whether transgenic expression of the molecule would increase immune responses against a weakly immunogenic murine tumor, neuro-2a. Tumor cells were transduced with a retroviral construct conta
Pathogenesis and pathophysiology of anemia in HIV infection.: Ann Hematol. 1997 Nov-Dec;75(5-6):179-87. Unique Identifier : AIDSLINE MED/98094947; Kreuzer KA; Rockstroh JK; Department of Medicine, University of Bonn, Germany.; Anemia occurs frequently among patients seropositive for human immunodeficiency virus (HIV), but its multifactorial origin complicates its differential diagnosis and adequate treatment. In addition, the etiology of anemia in HIV infection often remains unclear. In recent years several attempts have been undertaken to
Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection.: J Vet Med Sci. 1997 Nov;59(11):1049-51. Unique Identifier : AIDSLINE MED/98073989; Mizuno T; Momoi Y; Endo Y; Nishimura Y; Goto Y; Ohno K; Watari T; Tsujimoto H; Hasegawa A; Department of Veterinary Internal Medicine, Faculty of Agriculture,; University of Tokyo, Japan.; Feline immunodeficiency virus (FIV)-infected cells have been shown to undergo apoptosis by treatment with tumor necrosis factor alpha (TNF-alpha). This study detected a soluble factor which enhanced the apoptosis induced by TNF-alpha treatment. The sensitivity to TNF-alpha in the induction of apoptosis in a feline fib
Diagnosis: malignant syphilis.: Clin Infect Dis. 1997 Dec;25(6):1343, 1447. Unique Identifier : AIDSLINE MED/98093402; Wappner D; Carbia S; Gioseffi L; Schroh R; Losso MH; Department of Internal Medicine, Hospital J. M. Ramos Mejia, Buenos; Aires, Argentina.
Utility of fungal blood cultures for patients with AIDS.: Clin Infect Dis. 1997 Dec;25(6):1350-3. Unique Identifier : AIDSLINE MED/98093404; Mess T; Daar ES; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles,; California 90048, USA.; This study was designed to define the clinical utility of fungal blood cultures for human immunodeficiency virus type 1-infected individuals. A retrospective chart review was performed for all patients admitted to an inpatient AIDS unit who had evidence of an invasive fungal infection. During a 25-month period, 1,162
Oral hairy leukoplakia: clinicopathologic features, pathogenesis, diagnosis, and clinical significance.: Clin Infect Dis. 1997 Dec;25(6):1392-6. Unique Identifier : AIDSLINE MED/98093412; Triantos D; Porter SR; Scully C; Teo CG; Department of Oral Medicine, Eastman Dental Institute for Oral Health; Care Sciences, University of London, United Kingdom.; Oral hairy leukoplakia (OHL) is a lesion frequently, although not exclusively, observed in patients infected by human immunodeficiency viruses (HIV). OHL is clinically characterized by bilateral, often elevated, white patches of the lateral borders and dorsum of the tongue. Histologically, there is profound acanthosis
Reactivation of Chagas' disease in patients with AIDS: report of three new cases and review of the literature.: Clin Infect Dis. 1997 Dec;25(6):1397-400. Unique Identifier : AIDSLINE MED/98093413; Ferreira MS; Nishioka S de A; Silvestre MT; Borges AS; Nunes-Araujo FR; Rocha A; Centro de Ciencias Biomedicas, Universidade Federal de Uberlandia,; Brazil.; Three new cases of reactivation of Chagas disease in patients with AIDS, with central nervous system and/or cardiac involvement, are reported. One patient had histological evidence of acute esophageal and gastric Trypanosoma cruzi myositis, a previously unrecognized finding in patients with reactivated Chagas diseas
Bacteremia due to Campylobacter species: clinical findings and antimicrobial susceptibility patterns.: Clin Infect Dis. 1997 Dec;25(6):1414-20. Unique Identifier : AIDSLINE MED/98093417; Pigrau C; Bartolome R; Almirante B; Planes AM; Gavalda J; Pahissa A; Infectious Diseases Service, Hospitals Vall d'Hebron, Universitat; Autonoma, Barcelona, Spain.; From 1979 to 1996, 58 patients (mean age, 39.4 years) were treated for bacteremia due to Campylobacter species at the Hospitals Vall d Hebron in Barcelona, Spain . Bacteremia was considered to be hospital acquired in 30% of these patients. Almost all the patients (93%) had underlying
Rifampin-monoresistant tuberculosis in New York City, 1993-1994.: Clin Infect Dis. 1997 Dec;25(6):1465-7. Unique Identifier : AIDSLINE MED/98093424; Munsiff SS; Joseph S; Ebrahimzadeh A; Frieden TR; City of New York Department of Health, New York 10007, USA.; All New York City patients whose cultures yielded Mycobacterium tuberculosis with isolated resistance to rifampin in 1993 and 1994 were included in this study. Of the 96 patients, 48 (50%) had primary resistance, 32 (33%) had acquired resistance, and 16 17%) had unclassified resistance; 66% had histories of illicit dr
Acetylator status and tolerance of high-dose trimethoprim-sulfamethoxazole therapy among patients infected with human immunodeficiency virus.: Clin Infect Dis. 1997 Dec;25(6):1477-8. Unique Identifier : AIDSLINE MED/98093432; Smith CL; Brown I; Torraca BM; College of Pharmacy, Department of Pharmacy Practice, Ferris State; University, Big Rapids, Michigan, USA.
Successful desensitization of two patients who previously developed Stevens-Johnson syndrome while receiving trimethoprim-sulfamethoxazole.: Clin Infect Dis. 1997 Dec;25(6):1480. Unique Identifier : AIDSLINE MED/98093434; Douglas R; Spelman D; Czarny D; O'Hehir RE; Department of Allergy and Clinical Immunology, Alfred Hospital,; Prahran, Victoria, Australia.
Acute toxoplasmic meningitis in a patient with AIDS.: Clin Infect Dis. 1997 Dec;25(6):1482-3. Unique Identifier : AIDSLINE MED/98093436; Bach MC; Skarulis GJ; Department of Medicine, Manatee Memorial Hospital, Bradenton, Florida,; USA.
Cutaneous miliary tuberculosis in the AIDS era [letter]: Clin Infect Dis. 1997 Dec;25(6):1484. Unique Identifier : AIDSLINE MED/98093437; Hudson CP; Wood R; O'Keefe EA
Cutaneous miliary tuberculosis in a patient infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1997 Dec;25(6):1484-6. Unique Identifier : AIDSLINE MED/98093438; Antinori S; Bini T; Galimberti L; Meroni L; Esposito R
Cutaneous infection caused by Mycobacterium gordonae in a human immunodeficiency virus-infected patient receiving antimycobacterial treatment [letter]: Clin Infect Dis. 1997 Dec;25(6):1490-1. Unique Identifier : AIDSLINE MED/98093442; Rusconi S; Gori A; Vago L; Marchetti G; Franzetti F
Central nervous system infections with nontuberculous mycobacteria [letter]: Clin Infect Dis. 1997 Dec;25(6):1496-7. Unique Identifier : AIDSLINE MED/98093447; Cegielski JP; Wallace RJ Jr
[Acceptance of, compliance with and tolerance to antiretroviral treatment in patients with human immunodeficiency virus infection]: An Med Interna. 1997 Sep;14(9):445-9. Unique Identifier : AIDSLINE MED/98056914; Knobel H; Serrano C; Hernandez P; Pavesi M; Diez A; Servicio de Medicina Interna y Enfermedades Infecciosas, Hospital del; Mar., Barcelona.; BACKGROUND: The objective of the study is to assess the acceptance, compliance and side effects of antiretroviral therapy in relation to age, gender, risk group, HIV infection stage and type of treatment. METHODS: This is a cohort-observational study. Inclusion criteria were: consecutive non-selected IIV patients in w
[Pancreatitis associated with cotrimoxazole in an HIV-positive patient (letter)]: An Med Interna. 1997 Sep;14(9):487-8. Unique Identifier : AIDSLINE MED/98056927; Colomina Aviles J; Quintana Tomas L; Arenas Gracia M; Llorca Martinez E
[HIV/AIDS infection in Area 11 of Madrid: a panorama from the primary care viewpoint]: Aten Primaria. 1997 Sep 30;20(5):243-6. Unique Identifier : AIDSLINE MED/98030143; Roset Monros P; Rodriguez Fernandez C; Lobon Agundez C; Martin Alvarez R; Hernando Lopez T; Velazquez Garcia A; Unidad Docente de Medicina Familiar y Comunitaria, Area XI, Madrid.; OBJECTIVES: To find the clinical and epidemiological characteristics of HIV-positive patients and to study the possible differences between patients attended by primary care teams (PCT) and by the hospital specialist unit (SU). DESIGN: A descriptive cross-sectional study. SETTING: Six PCTs in Villaverde, Usera and Car
Profiles of pulp infiltrating lymphocytes at various times throughout feather regeneration in Smyth line chickens with vitiligo.: Autoimmunity. 1997;25(4):193-201. Unique Identifier : AIDSLINE MED/98003012; Shresta S; Smyth JR Jr; Erf GF; Department of Biological Sciences, Smith College, Northampton,; Massachusetts 01063, USA.; Smyth line (SL) chickens develop a spontaneous, autoimmune, posthatch loss of pigment cells (vitiligo) in regenerating feather tissue. Smyth line vitiligo (SLV) is associated with lymphocyte infiltrations prior to and throughout the development of the disorder. It was the purpose of this study to determine the type, r
Humoral and cellular immune response to elastin in patients with systemic sclerosis.: Autoimmunity. 1997;25(4):233-41. Unique Identifier : AIDSLINE MED/98003016; Daskalova M; Taskov H; Dimitrova E; Baydanoff S; Department of Biology and Immunology, Medical University, Pleven.; The humoral immune response against elastin and collagen was studied in parallel with the delayed type hypersensitivity (DTH) reaction to elastin and the percentage of lymphocyte subpopulations in peripheral blood in 20 patients with systemic sclerosis (SSc). An increase of anti-elastin antibodies of all subclasses wa
Truncated recurrent event survival models for methadone data.: Biometrics. 1997 Dec;53(4):1293-303. Unique Identifier : AIDSLINE MED/98085235; Salter A; Solomon PJ; Department of Statistics, University of Adelaide, Australia.; Truncated multivariate survival models are proposed for the analysis of data from the South Australian Methadone Program. Injecting drug users may have several entries to and exists from the program. A marginal approach for recurrent events is found to provide a useful and simplified basis for modeling the retention o
Hazard regression with interval-censored data.: Biometrics. 1997 Dec;53(4):1485-94. Unique Identifier : AIDSLINE MED/98085247; Kooperberg C; Clarkson DB; Department of Statistics, University of Washington, Seattle; 98195-4322, USA.; In a recent paper, Kooperberg, Stone, and Truong (1995a) introduced hazard regression (HARE), in which linear splines and their tensor products are used to estimate the conditional log-hazard function based on possibly censored, positive response data and one or more covariates. Model selection is carried out in an ad
Correlation between the release of IL-2 and granule-associated DNase activity in human lymphomononuclear cells stimulated with immunomodulating peptides and proteins. Role of different antigen-presenting cells.: Cytokine. 1997 Nov;9(11):809-17. Unique Identifier : AIDSLINE MED/98035685; Migliaccio M; Santiago E; Lopez-Moratalla N; Department of Biochemistry, University of Navarra, Pamplona, Spain.; The authors have already described that a series of short peptides, modelled after sequences related to human extracellular matrix (ECM) proteins and sharing some common structural features, activate Th1 clones through a process involving peptide presentation in HLA-DR proteins. Those peptides induce also LAK- and NK-
T-cell homeostasis in HIV-1 infection.: Semin Immunol. 1997 Dec;9(6):381-8. Unique Identifier : AIDSLINE MED/98070938; Margolick JB; Donnenberg AD; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, MD, USA.; Failure of T-cell homeostasis is an important feature of HIV-1 infection. Substantial evidence indicates that T-cell homeostasis is independent of CD4+ and CD8+ subsets, and this may contribute to the decline of CD4+ T cells to low levels in this disease. Moreover, failure of T-cell homeostasis appears to precede the
Dynamics of fine T-cell subsets during HIV disease and after thymic ablation by mediastinal irradiation.: Semin Immunol. 1997 Dec;9(6):389-96. Unique Identifier : AIDSLINE MED/98070939; Roederer M; De Rosa SC; Watanabe N; Herzenberg LA; Department of Genetics, Stanford University, Stanford, CA 94305-5125,; USA.; The T-cell compartment is considerably more complex than just CD4 and CD8 T cells. Indeed, we can identify dozens of functionally and phenotypically distinct subsets within the peripheral blood of humans. These subsets are differentially affected in diseases which may underly some of the functional defects attributabl
Thymic function in HIV-1 disease.: Semin Immunol. 1997 Dec;9(6):397-404. Unique Identifier : AIDSLINE MED/98070940; McCune JM; Gladstone Institute of Virology and Immunology, University of; California, San Francisco, San Francisco, CA 94141-9100, USA.; The thymus involutes over time and is generally considered to be non-functional in adults. If this is the case, T-cell depletion in adult HIV-1 disease would in part be due to insufficient intrathymic production. This review summarizes information relevant to the structure and function of the thymus under normal condi
Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line.: Blood. 1998 Jan 1;91(1):258-65. Unique Identifier : AIDSLINE MED/98077538; Biswas P; Delfanti F; Bernasconi S; Mengozzi M; Cota M; Polentarutti N; Mantovani A; Lazzarin A; Sozzani S; Poli G; AIDS Immunopathogenesis Unit, DIBIT, and the Division of Infectious; Diseases, San Raffaele Scientific Institute, Milan, Italy.; Induction of chemokine gene expression from peripheral blood mononuclear cells (PBMCs) stimulated by proinflammatory cytokines plays an important role in both wound repair and response to infectious agents. In the present study, we show that the proinflammatory cytokine interleukin-6 (IL-6) potently induced mRNA expre
Epidemiology of anemia in human immunodeficiency virus HIV)-infected persons: results from the multistate adult and adolescent spectrum of HIV disease surveillance project.: Blood. 1998 Jan 1;91(1):301-8. Unique Identifier : AIDSLINE MED/98077543; Sullivan PS; Hanson DL; Chu SY; Jones JL; Ward JW; Division of HIV/AIDS Prevention, National Center for HIV, STD, and TB; Prevention, Atlanta, Georgia, USA.; To study the incidence of, the factors associated with, and the effect on survival of anemia in human immunodeficiency virus HIV)-infected persons, we analyzed data from the longitudinal medical record reviews of 32,867 HIV-infected persons who received medical care from January 1990 through August 1996 in clinics, ho
Mechanisms of long-term donor-specific allograft survival induced by pretransplant infusion of lymphocytes.: Blood. 1998 Jan 1;91(1):324-30. Unique Identifier : AIDSLINE MED/98077546; Yang L; Du Temple B; Khan Q; Zhang L; Department of Cellular and Molecular Pathology, Multi Organ; Transplantation Program, The Toronto Hospital Research Institute,; University of Toronto, Toronto, Canada.; Pretransplantation donor-specific transfusion (DST) can enhance allograft survival in man and animals. However, due to the lack of a specific marker to identify donor-reactive cells in vivo in man and normal (nontransgenic) animals, the underlying mechanism remains unknown. In this study, we use 2CF1 transgenic mice e
[A study on disclosure by HIV positives by use of simulation using case vignettes]: Nippon Koshu Eisei Zasshi. 1997 Oct;44(10):749-59. Unique Identifier : AIDSLINE MED/98098821; Arakawa O; Health Administration Center, Shimane University.; AIDS patients/HIV positives have been increasing in Japan , but a large proportion of university students, who have high risk sexual behavior, are not aware of the danger of HIV infection. Because of little disclosure by AIDS patients/HIV positives in Japan, the students have a poor
The effect of exercise on lymphocyte redistribution and leucocyte function in asymptomatic HIV-infected subjects.: Brain Behav Immun. 1997 Sep;11(3):217-27. Unique Identifier : AIDSLINE MED/98086452; Phillips EJ; Ottaway CA; Freedman J; Kardish M; Li J; Singer W; Fong IW; St. Michael's Hospital, Department of Medicine, University of Toronto,; Canada.; This study was undertaken to examine the responsiveness of circulating leucocyte and lymphocyte populations to the physiological demands of exercise in asymptomatic HIV-infected subjects with CD4+ counts greater than 500/microliter. Thirteen subjects infected with HIV and 14 control subjects underwent 20 min of define
Advanced HIV infection treated with zidovudine monotherapy: lifetime values of absolute cost-effectiveness as a pharmacoeconomic reference for future studies evaluating antiretroviral combination treatments. The Osservatorio SIFO sui Farmaci.: Ann Pharmacother. 1997 Dec;31(12):1447-54. Unique Identifier : AIDSLINE MED/98078335; Messori A; Becagli P; Berto V; Trippoli S; Font M; Tosolini F; Venturini F; Martini N; Drug Information Center, Azienda Ospedaliera Careggi, Firenze, Italy.; md3439@mclink.it; OBJECTIVE: This study was undertaken to evaluate the cost and the effectiveness of zidovudine monotherapy in patients with advanced HIV infection and to derive preliminary data on the cost-effectiveness of the triple treatment with saquinavir plus zalcitabine plus zidovudine compared with zidovudine alone. DESIGN: We
Update: trends in AIDS incidence--US, 1996 [news]: Ann Pharmacother. 1997 Dec;31(12):1569. Unique Identifier : AIDSLINE MED/98078360
Commercially motivated renal transplantation: results in 540 patients transplanted in India. The Living Non-Related Renal Transplant Study Group.: Clin Transplant. 1997 Dec;11(6):536-44. Unique Identifier : AIDSLINE MED/98072979; Commercial renal transplantation is widely condemned on moral and ethical grounds. Moreover, previous studies involving small numbers of patients, mostly from tertiary care centers, have reported poor patient and graft survival. The Living Non-Related Renal Transplant Study Group was established to determine the overa
Gene transfer into haemopoietic cells.: Baillieres Clin Haematol. 1997 Sep;10(3):445-65. Unique Identifier : AIDSLINE MED/98083347; Stocking C; Baum C; Abt. Zell- und Virusgenetik, Heinrich-Pette-Institut fur; Experimentelle Virologie und Immunologie, Hamburg, Germany.; The therapeutic potential achievable by efficient transfer and expression of genes into haemopoietic stem cells (HSC) is enormous. In addition to inherited disorders such as haemoglobinopathies and lysosomal storage disorders, this technology can be applied to acquired disorders such as myelosuppression induced by ant
Interleukin-12 inhibits production of interleukin-5 but not of granulocyte/macrophage colony-stimulating factor by antigen-stimulated blood mononuclear cells in allergic bronchial asthmatics.: Int Arch Allergy Immunol. 1998 Jan;115(1):83-90. Unique Identifier : AIDSLINE MED/98090365; Okano Y; Nakamura Y; Sano T; Azuma M; Sone S; 3rd Department of Internal Medicine, University of Tokushima School of; Medicine, Tokushima City, Japan.; Bronchial asthma, characterized by eosinophilic inflammation in airways, may involve Th2-type cytokines such as interleukin-5 IL-5). IL-12, a newly established cytokine, induces IFN-gamma production, which may have a regulatory effect on the production of Th2-type cytokines. We examined the effects of IL-12 on the pro
House dust mite allergen characterisation: implications for T-cell responses and immunotherapy.: Int Arch Allergy Immunol. 1998 Jan;115(1):9-14. Unique Identifier : AIDSLINE MED/98090355; Thomas WR; Smith W; Hales BJ; Division of Molecular Biology, TVW Telethon Institute for Child Health; Research, West Perth, Australia.; T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle
[A missed opportunity (letter)]: Can Fam Physician. 1997 Dec;43:2107, 2109. Unique Identifier : AIDSLINE MED/98088363; Tessier D
The use of multiple antigenic peptide (MAP) in the immunodiagnosis of human immunodeficiency virus infection.: Biochem Mol Biol Int. 1997 Nov;43(4):713-21. Unique Identifier : AIDSLINE MED/98046541; Shin SY; Lee MK; Kim SY; Jang SY; Hahm KS; Peptide Engineering Research Unit, Korea Research Institute of; Bioscience and Biotechnology, KIST, Taejon, Korea.; In order to develop an ELISA system for the antibody detection of HIV-1 or HIV-2 infections, MAPs for HIV-1 gp41(584-618) and HIV-2 gp36(574-602) corresponding to the immunodominant regions of HIV-1 gp41 and HIV-2 gp36 were used as coating antigens in the ELISA. The MAPs were synthesized by the solid phase method usin
Inhibition of interleukin-6-induced human immunodeficiency virus type 1 expression by anti-gp130 monoclonal antibody.: Biochem Mol Biol Int. 1997 Nov;43(4):733-40. Unique Identifier : AIDSLINE MED/98046543; Okamoto M; Yasukawa K; Katsuura K; Baba M; Division of Human Retroviruses, Faculty of Medicine, Kagoshima; University, Japan.; Interleukin 6 (IL-6) has been reported to upregulate the expression of human immunodeficiency virus type 1 (HIV-1) in infected monocyte/macrophages. Since IL-6 signal is transduced through the membrane glycoprotein gp130, we investigated the inhibitory effect of anti-gp130 monoclonal antibody (mAb) on IL-6-induced vir
Employment protection for persons with AIDS: an idea whose time has come.: Nurs Spectr (Wash D C). 1996 Jan 2;6(1):23. Unique Identifier : AIDSLINE MED/98085620; Andreola NM
To test or not to test--keep it a question.: Nurs Spectr (Wash D C). 1997 Apr 7;7(7):20. Unique Identifier : AIDSLINE MED/98093279; Scipio-Bannerman J
Rural human immunodeficiency virus care [letter]: Arch Fam Med. 1998 Jan-Feb;7(1):14. Unique Identifier : AIDSLINE MED/98103927; Goldschmidt RH; Willard CL; Liljestrand P
Adenovirus-induced liver necrosis in a case of AIDS.: Virchows Arch. 1997 Dec;431(6):469-72. Unique Identifier : AIDSLINE MED/98090615; Dombrowski F; Eis-Hubinger AM; Ackermann T; Blumel J; Spengler U; Pfeifer U; Pathologisches Institut, Universitat Bonn, Germany.; Adenovirus-induced liver necrosis is rare. Because the era of AIDS (acquired immunodeficiency syndrome) this entity was seen predominantly in infants suffering from inborn immunodeficiency syndromes or from iatrogenic immunosuppression because of bone marrow or liver transplantation. Here, we report a case of a 30-yea
Incidence of tuberculosis in injection drug users in San Francisco: impact of anergy.: Am J Respir Crit Care Med. 1998 Jan;157(1):19-22. Unique Identifier : AIDSLINE MED/98106051; Daley CL; Hahn JA; Moss AR; Hopewell PC; Schecter GF; San Francisco General Hospital, Department of Medicine, University of; California, San Francisco 94143-0841, USA.; Between 1990 and 1994, we conducted a prospective study in five methadone maintenance clinics in San Francisco to determine the rate of tuberculosis (TB) in injection drug users, including those who were anergic. Of the 1,745 persons seen in the clinics, 1,109 completed an evaluation that included skin testing with tu
Possible mechanism for the generation of the HIV-1-resistant form of the CCR5 delta32 mutant chemokine receptor [letter]: Curr Biol. 1997 Sep 1;7(9):R529-30. Unique Identifier : AIDSLINE MED/97431702; Faulds D; Horuk R
Enveloped viruses: a common mode of membrane fusion?.: Curr Biol. 1997 Sep 1;7(9):R565-9. Unique Identifier : AIDSLINE MED/97431713; Hughson FM; Department of Molecular Biology, Princeton University, Princeton, New; Jersey 08544, USA. fhughson@molbiol.princeton.edu; Viruses use elaborate stratagems to enter cells. The HIV-1 envelope glycoprotein, which mediates both attachment and membrane fusion, has grudgingly begun to yield high-resolution structural information that suggests mechanistic similarities with the hemagglutinin protein of influenza virus.
The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export.: Curr Biol. 1997 Sep 1;7(9):619-28. Unique Identifier : AIDSLINE MED/97431683; Saavedra C; Felber B; Izaurralde E; Department of Molecular Biology, University of Geneva, 30 quai; Ernest-Ansermet, 1211 Geneva 4, Switzerland.; BACKGROUND: A hallmark of retroviral gene expression is that unspliced retroviral genomic RNA is exported to the cytoplasm, whereas endogenous intron-containing cellular RNAs are usually retained in the nucleus. In complex retroviruses, such as human immunodeficiency virus-1 (HIV-1), nuclear export is accomplished by
TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.: Curr Biol. 1997 Sep 1;7(9):652-60. Unique Identifier : AIDSLINE MED/97431687; Loetscher M; Amara A; Oberlin E; Brass N; Legler D; Loetscher P; D'Apuzzo M; Meese E; Rousset D; Virelizier JL; Baggiolini M; Arenzana-Seisdedos F; Moser B; Theodor-Kocher Institute University of Bern P.O. Box 99, CH-3000 Bern; 9, Switzerland.; BACKGROUND: Chemokines bind to specific receptors and mediate leukocyte migration to sites of inflammation. Recently, some chemokine receptors, notably CXCR4 and CCR5, have been shown to be essential fusion factors on target cells for infection by human immunodeficiency virus (HIV); the chemokines bound by these recep
Axonal sprouting in hippocampus of cats infected with feline immunodeficiency virus (FIV).: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):1-8. Unique Identifier : AIDSLINE MED/98097252; Mitchell TW; Buckmaster PS; Hoover EA; Whalen LR; Dudek FE; Department of Anatomy and Neurobiology, College of Veterinary Medicine; and Biomedical Sciences, Colorado State University, Fort Collins; 80523, USA.; Neurologic dysfunction and neuropathology are common findings in patients infected with HIV and in cats infected with feline immunodeficiency virus (FIV). The pathogenesis of lentivirus-associated alterations in the central nervous system CNS) is multifactorial. Because seizures, alterations in memory, and behavioral
In vitro selection of HIV-1 resistant to an anti-CD4 monoclonal antibody that inhibits virus transcription.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):17-26. Unique Identifier : AIDSLINE MED/98097254; Coudronniere N; David C; Hirn M; Devaux C; Laboratoire d'Immunologie des Infections Retrovirales, Institut de; Biologie, Montpellier, France.; Phase I studies using monoclonal antibodies (mAbs) that bind to the Ig-CDR3-like loop in domain 1 of CD4 (e.g., 13B8-2 mAb) have already been documented for HIV-1-infected patients. In vitro, such mAbs do not inhibit virus to cell fusion but are able to inhibit virus envelope-mediated syncytia formation. Moreover, the
Neutralizing antibodies against HIV determined by amplification of viral long terminal repeat sequences from cells infected in vitro by nonneutralized virions.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):27-34. Unique Identifier : AIDSLINE MED/98097255; Yang G; D'Souza MP; Vyas GN; Department of Laboratory Medicine, University of California, San; Francisco 94143, USA.; Based on the earliest intracellular synthesis of nascent HIV-1 long terminal repeat (LTR) fragments, we have established a heminested polymerase chain reaction (HNPCR) amplification of the 5 LTR sequences (LTR-HNPCR) for molecular assay of virus-neutralizing antibodies (VNAb). We incubated HIV antibodies with virus i
Repeated emergency department use by HIV-infected persons: effect of clinic accessibility and expertise in HIV care.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):35-41. Unique Identifier : AIDSLINE MED/98097256; Markson LE; Houchens R; Fanning TR; Turner BJ; Center for Research in Medical Education and Health Care and Division; of General Internal Medicine, Jefferson Medical College, Philadelphia,; Pennsylvania 19107-5083, USA.; Repeated emergency department (ED) visits by HIV-infected persons may signify poor access to care or treatment from inexperienced ambulatory providers. We examined features of 157 clinics following 6820 HIV-infected patients and associations with repeated (> or =2) ED visits by these patients in the year before their
Heterosexual HIV-1 transmission and viral load in hemophilic patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):42-5. Unique Identifier : AIDSLINE MED/98097257; Ragni MV; Faruki H; Kingsley LA; Department of Medicine, University of Pittsburgh School of Medicine; and The Hemophilia Center of Western Pennsylvania, 15213-4306, USA.; Only one fifth or fewer of the female sexual partners of HIV-1-infected men with hemophilia become infected. The risk factors associated with heterosexual transmission of HIV-1 are not well understood. To investigate the hypothesis that HIV-1 viral load may be related to heterosexual HIV-1 transmission, we measured HI
Severe hyperglycemia in an HIV clinic: preexisting versus drug-associated diabetes mellitus.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):46-50. Unique Identifier : AIDSLINE MED/98097258; Kilby JM; Tabereaux PB; Department of Medicine, University of Alabama at Birmingham,; 35294-2050, USA.; We determined the frequency and clinical nature of severe hyperglycemia in a university clinic for HIV-1-infected patients. The medical records of 1392 adult HIV-infected patients were reviewed for cases of severe hyperglycemia, defined as two or more serum glucose values >250 mg/dl or diabetes treatment during clinic
Association between serum total cholesterol and HIV infection in a high-risk cohort of young men.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):51-7. Unique Identifier : AIDSLINE MED/98097259; Claxton AJ; Jacobs DR Jr; Iribarren C; Welles SL; Sidney S; Feingold KR; Division of Epidemiology, School of Public Health, University of; Minnesota, Minneapolis 55454-1015, USA.; Low serum total cholesterol (TC) is associated with a variety of nonatherosclerotic diseases, but the association of TC with infectious disease has been little studied. In this study, we examined the relationship between serum TC and HIV infection in members of a large health maintenance organization in Northern Calif
Phylogenetic analysis of the nef gene reveals a distinctive monophyletic clade in Korean HIV-1 cases.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):58-68. Unique Identifier : AIDSLINE MED/98097260; Kang MR; Cho YK; Chun J; Kim YB; Lee I; Lee HJ; Kim SH; Kim YK; Yoon K; Yang JM; Kim JM; Shin YO; Kang C; Lee JS; Choi KW; Kim DG; Fitch WM; Kim S; Institute for Molecular Biology and Genetics and Medical College,; Seoul National University, Korea.; To study the genetic variation of the HIV-1 strains prevalent in South Korea , we analyzed the nef sequences derived from 46 HIV-1-positive individuals living in various geographic regions in Korea. Phylogenetic analysis revealed fou
Epstein-Barr virus DNA in the blood of infants, young children, and adults by age and HIV status.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):69-72. Unique Identifier : AIDSLINE MED/98097261; Brandt CD; Sison AV; Rakusan TA; Saxena ES; Kaufman TE; O'Donnell RM; Sever JL; Center for Virology, Immunology, and Infectious Diseases Research,; Children's Research Institute, Washington, DC, USA. brandtcd@aol.com; Polymerase chain reaction (PCR) methodology was used to detect Epstein-Barr virus (EBV) DNA in peripheral blood mononuclear cells (PBMCs) from children and adults whose HIV status (i.e., infected or uninfected) is known. Initial EBV infections especially occurred in children between the ages of 7 and 24 months. EBV-po
Epidemiology of HIV-1 infection in opiate users in Northern Thailand.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):73-8. Unique Identifier : AIDSLINE MED/98097262; Celentano DD; Jittiwutikorn J; Hodge MJ; Beyrer C; Nelson KE; The Johns Hopkins University, Baltimore, Maryland 21205, USA.; Characterizing the epidemiology of HIV-1 infection in Northern Thai opiate users is important in developing control strategies in this ethnically diverse and culturally distinct region. A cross-sectional survey of drug users first admitted between 1993 and 1995 at the Northern Drug Dependence Treatment Center, Mae Rim
Association between Cryptosporidium infection and animal exposure in HIV-infected individuals.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):79-82. Unique Identifier : AIDSLINE MED/98097263; Glaser CA; Safrin S; Reingold A; Newman TB; AIDS Prevention Studies and Pediatric Infectious Disease, University; of California, San Francisco, USA.; Cryptosporidium causes a debilitating illness in immunocompromised individuals, yet the source of sporadic Cryptosporidium infections is unknown. Because early cases of cryptosporidiosis were associated with animals, and pets are a source of companionship to individuals with AIDS, determination of the risk of cryptosp
Economic evaluation of an HIV prevention intervention for gay and bisexual male adolescents.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):83-90. Unique Identifier : AIDSLINE MED/98097264; Tao G; Remafedi G; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; The objective of this study was to evaluate the cost-effectiveness of an HIV prevention intervention for gay and bisexual male adolescents. The intervention included individualized risk assessment and counseling, peer education, optional HIV testing, and referrals to needed services. From 1989 to 1994, 501 male volunt
HIV Tat protein requirements for transactivation and repression of transcription are separable.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):9-16. Unique Identifier : AIDSLINE MED/98097253; Brown JA; Howcroft TK; Singer DS; Experimental Immunology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; The HIV Tat protein, primarily characterized as a transcriptional activator of the viral long terminal repeat (LTR), is also a potent repressor of major histocompatibility complex (MHC) class I transcription. In the present study, we demonstrate that these two functional activities are distinct and mediated by discret
Effect on serologic reactivity of P-to-W substitution in the apex of the V3 loop of the HIV-1 subtype B glycoprotein [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):91-2. Unique Identifier : AIDSLINE MED/98097265; Vanden Haesevelde M; DeLeys RJ; Van Geel A; Vanderborght B; de Sa M; Van Eynde G; Saman E
Lack of correlation between vertical transmission of HIV-1 and maternal antibody titers against autologous virus in human monocyte-derived macrophages [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):92-4. Unique Identifier : AIDSLINE MED/98097266; Mabondzo A; Narwa R; Roques P; Gras GS; Herve F; Parnet-Mathieu F; Lasfargues G; Courpotin C; Dormont D
Epidemiology of plantar verrucae in HIV-infected individuals [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):94-5. Unique Identifier : AIDSLINE MED/98097267; Kenyon E; Loveland L; Kilpatrick R; Barbosa P
Herpes simplex virus types 1 and 2, chlamydia, syphilis, and toxoplasma in pregnant Japanese women with HTLV-I [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):95-7. Unique Identifier : AIDSLINE MED/98097268; Hashido M; Lee FK; Nahmias AJ; Inouye S; Miyata K; Nagata Y; Sonoda S; Kawana T
Study of HTLV-I prevalence in patients with sexually transmitted diseases in Perm and Ekaterinburg, Russia [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):97-8. Unique Identifier : AIDSLINE MED/98097269; Sankov MN; Bobkova MR; Khanina TA; Bobkov AF; Zverev SY; Terskikh VA
[The discovery of three novel human viruses, human herpesviruses 6, 7, and 8]: Bull Acad Natl Med. 1997 Jun-Jul;181(6):1009-22. Unique Identifier : AIDSLINE MED/98064365; Agut H; Calvez V; Fillet AM; Huraux JM; Laboratoire de Virologie, CERVI, Groupe Hospitalier Pitie-Salpetriere,; Paris. henri.agut@psl.ap-hop-paris.fr; Three novel human herpesviruses have been discovered in the last years: human herpesvirus 6 (HHV-6) in 1986, human herpesvirus 7 HHV-7) in 1990, human herpesvirus 8 (HHV-8) in 1994. HHV-6 and HHV-7 were identified after their isolation from blood lymphocyte cultures, while HHV-8 was first detected by means of a specif
[Human herpesvirus 8 and associated diseases: Kaposi's sarcoma, body cavity based lymphoma and multicentric Castleman disease: clinical and molecular epidemiology]: Bull Acad Natl Med. 1997 Jun-Jul;181(6):1023-34. Unique Identifier : AIDSLINE MED/98064366; Gessain A; Departement des Retrovirus, Institut Pasteur, Paris.; agessain@pasteur.fr; A new human virus belonging to the herpesvirinae family was recently isolated and characterized. This virus called human herpesvirus 8 is considered as the etiological agent or as a major cofactor of all the clinical forms (HIV associated or not) of Kaposi s sarcoma. HHV8 is also associated with rare B cell lymphomas
[Importance of measurement of plasma viral load for the therapeutic follow-up of children infected with HIV-1. Study of its evolution according to modifications of treatment in 55 children]: Bull Acad Natl Med. 1997 Jun-Jul;181(6):1163-74; discussion 1174-6. Unique Identifier : AIDSLINE MED/98064376; Lasfargues G; Courpotin C; Nicolas JC; Dollfus C; Service d'hematologie et d'oncologie pediatrique, Hopital; Armand-Trousseau, Paris.; Since 1987 we started to treat all vertically HIV-1 infected newborns by an antiretroviral therapy as soon as the diagnosis was confirmed. From the study of 55 HIV-1 infected children followed at Armand Trousseau Hospital (Paris, France ) we retrospectively evaluated the use of the
[Effectiveness of measures taken in France to reduce the risks of heroin addiction via intravenous route]: Bull Acad Natl Med. 1997 Jun-Jul;181(6):1177-85; discussion 1186-9. Unique Identifier : AIDSLINE MED/98064377; Henrion R; French policy towards illicit drug use is based on abstinence, and on withdrawal for drug-dependent users. Its basis is the December 31, 1970 law, which is still applicable, and prohibits the use of theses drugs, even in private. It provides for prison sentences for users who do not accept to be treated. Under the pre
[The desire for pregnancy in couples where the woman is HIV seronegative and her spouse is seropositive]: Bull Acad Natl Med. 1997 Jun-Jul;181(6):1243-54. Unique Identifier : AIDSLINE MED/98064380; Henrion R
[Thematic meeting. "Herpes virus and oncogenesis"]: Bull Acad Natl Med. 1997 Jun-Jul;181(6):975-8; discussion 979-80. Unique Identifier : AIDSLINE MED/98064362; de The G; Institut Pasteur, Paris.
Anti-HIV genetic treatment of antigen-specific human CD4 lymphocytes for adoptive immunotherapy of opportunistic infections in AIDS.: Gene Ther. 1997 Nov;4(11):1216-24. Unique Identifier : AIDSLINE MED/98086582; Manca F; Fenoglio D; Franchin E; Saverino D; Li Pira G; Buffa F; Bignardi D; Del Pup L; Palu G; Department of Immunology, San Martino Hospital, University of Genoa,; Italy.; HIV-1 infection results in the loss of CD4+ T helper lymphocytes which make up the immune repertoire. This leads to opportunistic infections that define AIDS. Here, we show that CD4 T cell lines from normal donors with specificity for different antigens can be rendered resistant to HIV-1 replication by retroviral tran
Inhibition of HIV-1 replication by a Tat transdominant negative mutant in human peripheral blood lymphocytes from healthy donors and HIV-1-infected patients.: Gene Ther. 1997 Nov;4(11):1261-9. Unique Identifier : AIDSLINE MED/98086588; Rossi C; Balboni PG; Betti M; Marconi PC; Bozzini R; Grossi MP; Barbanti-Brodano G; Caputo A; Department of Experimental and Diagnostic Medicine, University of; Ferrara, Italy.; It was previously shown that a tat mutant (tat22) where cysteine 22 is substituted by glycine behaves as a transdominant negative mutant in Jurkat T cells lytically or latently infected by HIV-1. In this study we demonstrate that tat22 controls HIV-1 replication in primary cells. This effect was observed both after in
Cervical carcinoma cells transfected with the CD80 gene elicit a primary cytotoxic T lymphocyte response specific for HPV 16 E7 antigens.: Cancer Gene Ther. 1997 Nov-Dec;4(6):377-82. Unique Identifier : AIDSLINE MED/98072906; Kaufmann AM; Gissmann L; Schreckenberger C; Qiao L; Department of Microbiology and Immunology, Stritch School of Medicine,; Loyola University Medical Center, Maywood, Illinois 60153, USA.; Cervical carcinoma is strongly associated with human papillomavirus (HPV) type 16, and the transforming viral genes E6 and F7 are steadily expressed by the tumor cells. Therefore these viral oncogenes may be regarded as tumor-associated antigens. Our previous studies showed that cervical cancer cells after introductio
Identification of aptamers against the DNA template for in vitro transcription of the HIV-1 TAR element.: Antisense Nucleic Acid Drug Dev. 1997 Aug;7(4):369-80. Unique Identifier : AIDSLINE MED/97448864; Boiziau C; Dausse E; Mishra R; Duconge F; Toulme JJ; INSERM U 386, IFR Pathologies Infectieuses, Universite Victor Segalen,; Bordeaux, France.; We have extracted from a random population of about 10(9) oligodeoxynucleotides a series of 21-mers that are able to bind to a folded DNA 76-mer used as a template for in vitro transcription of the TAR element of the retrovirus HIV-1, by the T7 RNA polymerase. Five aptastrucs, that is, aptamers able to bind to the str
Progress toward the structure and therapeutic use of the hairpin ribozyme.: Antisense Nucleic Acid Drug Dev. 1997 Aug;7(4):403-11. Unique Identifier : AIDSLINE MED/97448867; Earnshaw DJ; Gait MJ; Medical Research Council, Laboratory of Molecular Biology, Cambridge,; UK.; The hairpin ribozyme is one of a number of small catalytic RNAs that are excellent paradigms for RNA structure-function analysis and have potential also as therapeutic agents. This review outlines current understanding of the structure of the hairpin ribozyme and its basis for catalytic activity. Included also is a di
The design of antisense RNA.: Antisense Nucleic Acid Drug Dev. 1997 Aug;7(4):439-44. Unique Identifier : AIDSLINE MED/97448871; Sczakiel G; Deutsches Krebsforschungszentrum, Heidelberg, Germany.; Antisense nucleic acids comprise short-chain synthetic oligonucleotides, often oligodeoxyribonucleotides (ODN) of less than approximately 30 nucleotides and substantially longer sequences formed by ribonucleic acids (RNA). Both groups differ with respect to several properties, including their generation, the mode of d
Studies on the placental transfer of cell-free human immunodeficiency virus and p24 antigen in an ex vivo human placental model.: J Soc Gynecol Investig. 1994 Jan-Mar;1(1):45-8. Unique Identifier : AIDSLINE MED/98081015; Bawdon RE; Gravell M; Hamilton R; Sever J; Miller R; Gibbs CJ; Department of Obstetrics and Gynecology, University of Texas; Southwestern Medical Center, Dallas 75235-9032, USA.; OBJECTIVE: We studied whether the human placenta has the structural integrity to impede transplacental passage of cell-free human immunodeficiency virus (HIV)-1 or p24 antigen from the maternal to the fetal circulation. METHODS: Nine term human placentas from uncomplicated vaginal or cesarean section deliveries were s
Aetiology of Kaposi's sarcoma: current understanding and implications for therapy.: Mol Med Today. 1997 Nov;3(11):488-94. Unique Identifier : AIDSLINE MED/98092592; Boshoff C; Weiss RA; Institute of Cancer Research, Chester Beatty Laboratories, London, UK,; cboshoff@icr.uk.ac; Kaposi s sarcoma is an angiogenic neoplasm composed of endothelial and spindle cells. The enormous increase in Kaposi s sarcoma with HIV infection, and recent discovery that a new human herpesvirus (Kaposi s sarcoma-associated herpesvirus, also called human herpesvirus 8) is present in this tumor, has activated intens
Liver disease in the immunocompromised patient.: Pathology (Phila). 1994;3(1):185-206. Unique Identifier : AIDSLINE MED/98082468; Robert ME; Department of Pathology, Yale University School of Medicine, New; Haven, CT 06520-8023, USA.; This chapter reviews the most common diseases of the liver that are associated immunodeficiencies resulting from AIDS, chemotherapy and radiation, and bone marrow and solid organ transplantation. Conditions described include liver disease, infection, venoocclusive disease, graft versus host disease, and others.
Individual differences in peripheral blood immunological and hormonal measures in adult male rhesus macaques (Macaca mulatta): evidence for temporal and situational consistency.: Am J Primatol. 1998;44(1):29-41. Unique Identifier : AIDSLINE MED/98106726; Capitanio JP; Mendoza SP; Lerche NW; California Regional Primate Research Center, University of California,; Davis 95616, USA. jpcapitanio@ucdavis.edu; A growing body of research has indicated that consistent individual differences exist in physiological systems with which the immune system interacts. Few data have been reported that demonstrate stable individual differences in immunological measures, however. In the present study, enumerative measures of immune syst
Synthesis of L-ribofuranosyl C-nucleosides.: Carbohydr Res. 1997 Aug 25;303(1):33-8. Unique Identifier : AIDSLINE MED/98005665; Liang C; Ma T; Cooperwood JS; Du J; Chu CK; Department of Medicinal Chemistry, College of Pharmacy, University of; Georgia, Athens 30602, USA.; C-Nucleosides, 4-amino-8-(beta-L-ribofuranosyl)pyrazolo[1, 5-a]-1,3,5-triazine (12) and 4-amino-7-(beta-L-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidine L-9-deazaadenosine, 22), were synthesized from the key intermediate, 3-dimethylamino-2-(2,3-O-isopropylidene-5-O-trityl-L-ribofuranosy- l) acrylonitrile (8), which was pr
HIV testing among Haitian women: lessons in the recognition of risk.: Health Educ Behav. 1997 Dec;24(6):736-45. Unique Identifier : AIDSLINE MED/98073085; Wingerd JL; Page JB; Department of Psychiatry, University of Miami, Coral Gables, FL, USA.; JWingerd@bellsouth.net; Haitian women in Miami, Florida, responded to recruitment for testing of HIV antibody serostatus in ways that demonstrated the value of ethnographic methods for studying reactions to this kind of test, especially pre- and posttest counseling sessions. A total of 155 women between 14 and 61 years old, recruited in Miam
Specific cleavage of hybrid proteins by proteinase encoded by the KEX2 gene.: Biochemistry (Mosc). 1997 Aug;62(8):850-7. Unique Identifier : AIDSLINE MED/98024628; Bessmertnaya LYa; Loiko II; Goncharova TI; Ivanov NV; Rumsh LD; Antonov VK; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian; Academy of Sciences, Moscow, Russia. mila@enzyme.siobc.ras.ru; A method for isolation of the KEX2-gene-encoded membrane-bound proteinase from alpha-cells of Saccharomyces cerevisiae yeast has been modified. The isolated enzyme hydrolyzes peptides and proteins with basic amino acid pairs which are cleaved at the C-ends of their peptide bonds. Because KEX2 proteinase is located wit
Cytokines and anaemia in human immunodeficiency virus infection.: Cytokines Cell Mol Ther. 1997 Sep;3(3):179-86. Unique Identifier : AIDSLINE MED/98088415; Means RT Jr; Hematology/Oncology Division, University of Cincinnati College of; Medicine, OH, USA. rmeansjr@mail.one.net; The anaemia that is a common complication of human immunodeficiency virus (HIV) infection bears many similarities to the anaemia of chronic disease. These similarities include an impaired erythropoietin (EPO) response to anaemia, reduced concentrations of marrow progenitors giving rise to erythroid colonies, abnormali
In vitro generation of human dendritic cells and cell therapy.: Cytokines Cell Mol Ther. 1997 Sep;3(3):187-96. Unique Identifier : AIDSLINE MED/98088416; Gluckman JC; Canque B; Chapuis F; Rosenzwajg M; Laboratoire d'Immunologie Biologique, hopital de la Pitie-Salpetriere,; Paris, France. jeanclaude.gluckman@psl.ap-hop.paris.fr; Dendritic cells (DC) are the most potent antigen-presenting cells: they, only, can prime naive T lymphocytes and even elicit generation of cytotoxic T lymphocytes to soluble antigens. Thus ex vivo antigen-pulsed DC represent a potentially powerful tool to elicit T-cell mediated responses against viral or tumor-associa
Synthesis and CD studies of an 88-residue peptide containing the main receptor binding site of HTLV-I SU-glycoprotein.: J Pept Sci. 1997 Sep-Oct;3(5):347-53. Unique Identifier : AIDSLINE MED/98053397; Goetz M; Geoffre S; Busetta B; Manigand C; Nespoulous C; Londos-Gagliardi D; Guillemain B; Hospital M; Unite de Biophysique Structurale, CNRS, Universite de Bordeaux,; France.; Essential HTLV-1 biological functions, like host-cell receptor recognition, depend on the structural motives on the surface glycoprotein gp46. We defined a peptide of 88 amino acids [Arg147-Leu234] corresponding to the central part of the protein sequence, where major neutralizing epitopes are localized. After evaluat
The design of a specific ligand of HIV gp120.: J Pept Sci. 1997 Sep-Oct;3(5):383-90. Unique Identifier : AIDSLINE MED/98053401; Scarselli M; Facchiano A; Russo G; Molinari H; Ragona L; Zetta L; Niccolai N; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; The crystal structure of CD4 suggested that the C/G38 and C/L44 replacements with the consequent cystine bridge formation are compatible with the native structure of that molecular moiety. As the NQGSF sequence, corresponding to the 39-43 fragment of human CD4 protein, was found to be involved in the HIV gp120 interac
Control of herpetic stromal keratitis using CTLA4Ig fusion protein.: Clin Immunol Immunopathol. 1998 Jan;86(1):88-94. Unique Identifier : AIDSLINE MED/98096413; Gangappa S; Manickan E; Rouse BT; Department of Microbiology, College of Veterinary Medicine, University; of Tennessee, Knoxville 37996-0845, USA.; Herpetic stromal keratitis (HSK) is an immunoinflammatory lesion in the cornea of the eye set off by infection with herpes simplex virus (HSV). The disease appears to be orchestrated by CD4+ T cells of the Th1 phenotype but the identity of target antigens involved in HSK remains unknown. In this proposal, we investiga
Adherence to clinical guidelines for the therapeutic management of HIV disease.: Clin Invest Med. 1997 Dec;20(6):381-7. Unique Identifier : AIDSLINE MED/98075556; Heath KV; Hogg RS; Singer J; Schechter MT; O'Shaughnessy MV; Montaner JS; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's; Hospital.; OBJECTIVE: To determine the knowledge of HIV-disease management and the adherence to contemporary guidelines among British Columbia physicians whose practices focused on HIV/AIDS. DESIGN: Self-administered mail survey. PARTICIPANTS: All 659 physicians registered in a province-wide HIV/AIDS drug treatment program. OUTC
[A case of polyneuropathy with B-CLL and HTLV-I associated myelopathy (HAM)]: Rinsho Shinkeigaku. 1997 Aug;37(8):701-3. Unique Identifier : AIDSLINE MED/98067939; Akamatsu MM; Mitsui Y; Kihara M; Ohtsuka K; Takahashi M; Department of Neurology, Kinki University School of Medicine.; We report a case of polyneuropathy associated with chronic B lymphoid leukemia (B-CLL) and HAM. A 65-year-old man had an initial onset with polyneuropathy, then myelopathy appeared. High HTLV-I antibody and anti-ganglioside antibodies were observed. The biopsy examination of the sural nerve showed mainly demyelinated
The fidelity of misinsertion and mispair extension throughout DNA synthesis exhibited by mutants of the reverse transcriptase of human immunodeficiency virus type 2 resistant to nucleoside analogs.: Eur J Biochem. 1997 Nov 15;250(1):106-14. Unique Identifier : AIDSLINE MED/98092294; Taube R; Avidan O; Hizi A; Department of Cell Biology and Histology, Sackler School of Medicine,; Tel Aviv University, Israel.; The AIDS-causing retroviruses, human immunodeficiency virus types 1 and type 2 (HIV-1 and HIV-2, respectively) undergo extensive genetic variations, which effect their pathogenesis and resistance to drug therapy. It was postulated that this genetic hypervariability results from high rates of viral replication in conju
Chlamydia pneumoniae respiratory infections among patients infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1997 Oct;16(10):720-6. Unique Identifier : AIDSLINE MED/98069014; Comandini UV; Maggi P; Santopadre P; Monno R; Angarano G; Vullo V; Department of Infectious and Tropical Diseases, University La Sapienza; of Rome, Italy.; Thirteen cases of Chlamydia pneumoniae infection in patients seropositive for the human immunodeficiency virus (HIV) are described. The occurrence, the clinical spectrum, and the significance of the infection during HIV disease are compared with data reported in the literature. Chlamydia pneumoniae infection was estab
Efficacy of different methods for detection of low Cryptosporidium parvum oocyst numbers or antigen concentrations in stool specimens.: Eur J Clin Microbiol Infect Dis. 1997 Oct;16(10):732-6. Unique Identifier : AIDSLINE MED/98069016; Ignatius R; Eisenblatter M; Regnath T; Mansmann U; Futh U; Hahn H; Wagner J; Institut fur Medizinische Mikrobiologie und Infektionsimmunologie,; Klinikum Benjamin Franklin, Freien Universitat Berlin, Germany.; The detection of Cryptosporidium parvum oocysts in stool specimens by acid-fast (AF) stains or immunofluorescence assays IFA) requires the presence of large numbers of oocysts. To determine whether new commercially available enzyme immunoassays EIAs) are more sensitive alternatives, three EIAs, a direct IFA, and the m
Low prevalence of active parvovirus B19 infection in HIV-infected patients.: Eur J Clin Microbiol Infect Dis. 1997 Oct;16(10):760-2. Unique Identifier : AIDSLINE MED/98069024; Raguin G; Leruez-Ville M; Gregoire V; Deplanche M; Leport C; Morinet F; Vilde JL; Service de Maladies Infectieuses et Tropicales, Hopital Bichat-Claude; Bernard, Paris, France.; In a prospective study to determine the prevalence of parvovirus B19 in adult patients positive for the human immunodeficiency virus, a series of 55 consecutively presenting patients was tested for antibodies to parvovirus B19 and parvovirus B19 DNA. Specific IgG antibodies were detected in 96% of cases; specific IgM
Human T-cell lymphotropic virus infection in pregnant women in Spain [letter]: Eur J Clin Microbiol Infect Dis. 1997 Oct;16(10):771-3. Unique Identifier : AIDSLINE MED/98069027; Tuset C; Gutierrez M; Carbonell C; Tuset T; Soriano V
Pulmonary coinfection by Salmonella enteritidis and Pneumocystis carinii in a patient with the acquired immunodeficiency syndrome [letter]: Eur J Clin Microbiol Infect Dis. 1997 Oct;16(10):773-4. Unique Identifier : AIDSLINE MED/98069028; Salelles P; Roig P; Orti A; Navarro V; Ortiz de la Tabla V; Galant J; Merino J
Pleural disease and acquired immune deficiency syndrome.: Eur Respir J. 1997 Nov;10(11):2638-43. Unique Identifier : AIDSLINE MED/98086076; Light RW; Hamm H; Pulmonary Disease Program, St Thomas Hospital, Nashville, TN, USA.; Patients with acquired immune deficiency syndrome (AIDS) do not frequently have pleural complications. However, pneumothorax is a troublesome complication of patients with AIDS. At some medical centres, more than 50% of patients with spontaneous pneumothorax have AIDS. Most patients with spontaneous pneumothorax and A
Female genital mutilation: the potential for increased risk of HIV infection.: Int J Gynaecol Obstet. 1997 Nov;59(2):153-5. Unique Identifier : AIDSLINE MED/98092180; Kun KE; NJ Women and AIDS Network, New Brunswick, USA.
Spinal cord compression by heterotopic ossification associated with pseudohypoparathyroidism.: J Int Med Res. 1997 Nov-Dec;25(6):364-8. Unique Identifier : AIDSLINE MED/98088609; Yamamoto Y; Noto Y; Saito M; Ichizen H; Kida H; Department of Internal Medicine, Kanazawa National Hospital, Japan.; This report describes a 37-year-old man presenting with a gait disturbance due to spastic paraparesis. Physical findings showed typical features of Albright s hereditary osteodystrophy, including short stature, obesity, brachydactyly and dental hypoplasia. He was diagnosed as having pseudohypoparathyroidism type Ia, oi
High mucosal levels of tumor necrosis factor alpha messenger RNA in AIDS-associated cytomegalovirus-induced esophagitis.: Gastroenterology. 1998 Jan;114(1):77-82. Unique Identifier : AIDSLINE MED/98089822; Wilcox CM; Harris PR; Redman TK; Kawabata S; Hiroi T; Kiyono H; Smith PD; Department of Medicine, University of Alabama School of Medicine,; Birmingham, USA.; BACKGROUND & AIMS: To evaluate the role of tumor necrosis factor alpha (TNF-alpha), a key inflammatory cytokine, in cytomegalovirus-associated gastrointestinal disease, we quantitated the level of TNF-alpha messenger RNA (mRNA) in esophageal mucosa from patients with cytomegalovirus-associated esophagitis and acqui
5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II [see comments]: Genes Dev. 1997 Dec 15;11(24):3306-18. Unique Identifier : AIDSLINE MED/98070332; McCracken S; Fong N; Rosonina E; Yankulov K; Brothers G; Siderovski D; Hessel A; Foster S; Shuman S; Bentley DL; Amgen Institute and Ontario Cancer Institute, Toronto, Ontario M5G; 2C1, Canada.; We have investigated the role of the RNA Polymerase II (Pol II) carboxy-terminal domain (CTD) in mRNA 5 capping. Transcripts made in vivo by Pol II with a truncated CTD had a lower proportion of capped 5 ends than those made by Pol II with a full-length CTD. In addition, the enzymes responsible for cap synthesis, RN
Histone acetyltransferases regulate HIV-1 enhancer activity in vitro.: Genes Dev. 1997 Dec 15;11(24):3327-40. Unique Identifier : AIDSLINE MED/98070334; Sheridan PL; Mayall TP; Verdin E; Jones KA; The Salk Institute for Biological Studies, La Jolla, California; 92037-1099, USA.; Specific inhibitors of histone deacetylase, such as trichostatin A (TSA) and trapoxin (TPX), are potent inducers of HIV-1 transcription in latently infected T-cell lines. Activation of the integrated HIV-1 promoter is accompanied by the loss or rearrangement of a positioned nucleosome (nuc-1) near the viral RNA start
Hepatitis C viral infection in the immunosuppressed patient.: Hepatology. 1998 Jan;27(1):2-6. Unique Identifier : AIDSLINE MED/98085878; Collier J; Heathcote J; The Toronto Hospital, University of Toronto, Ontario, Canada.
Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients.: Hepatology. 1998 Jan;27(1):223-7. Unique Identifier : AIDSLINE MED/98085910; Booth JC; Kumar U; Webster D; Monjardino J; Thomas HC; Academic Department of Medicine, St. Mary's Hospital Medical School,; Imperial College of Science, Technology and Medicine, London, England,; UK.; The hypervariable region (HVR) of the E2/NS1 region of hepatitis C virus (HCV) varies greatly between viral isolates with high rates of genomic change reported during the course of chronic infection. The HVR is thought to encode a structurally unconstrained envelope protein containing several linear B cell epitopes re
HLA-DR-positive dendritic cells of the normal human choroid plexus: a potential reservoir of HIV in the central nervous system.: Hum Pathol. 1998 Jan;29(1):88-93. Unique Identifier : AIDSLINE MED/98105884; Hanly A; Petito CK; Department of Pathology, University of Miami School of Medicine, FL; 33136, USA.; In a previous study of choroid plexus (CPx) from patients with the acquired immunodeficiency syndrome (AIDS), we found a population of stromal cells infected with the human immunodeficiency virus (HIV). To determine whether these represented antigen-presenting dendritic cells, we examined the phenotype of normal human
Characterization of the murine H2-M3wt-restricted CD8 response against a hydrophobic, protease-resistant, phospholipid-associated antigen from Listeria monocytogenes.: Immunol Rev. 1997 Aug;158:123-8. Unique Identifier : AIDSLINE MED/97459309; Kurlander R; Nataraj C; Department of Medicine, Duke Medical Center, Durham, North Carolina; 27710, USA. kurla001@mc.duke.edu; Mice infected with Listeria monocytogenes (LM) generate protective CD8 cells of varying specificity. One subset, unlike conventional LM-immune CD8 cells, can respond to antigen-presenting cells (APC) treated with heat-killed LM HKLM). These cells proved to have surprisingly uniform specificity, recognizing a product w
Acquired immunity to an intracellular pathogen: immunologic recognition of L. monocytogenes-infected cells.: Immunol Rev. 1997 Aug;158:137-46. Unique Identifier : AIDSLINE MED/97459311; Bouwer HG; Barry RA; Hinrichs DJ; Earle A. Chiles Research Institute, Portland, Oregon, USA.; bouwera@ohsu.edu; Listeria monocytogenes (L. monocytogenes) is a pathogenic bacterium, and subclinical infection in mice is utilized as a prototypic model to investigate the development and expression of acquired resistance to facultative intracellular organisms. A key virulence factor of L. monocytogenes is the hemolysin listeriolysin
Interleukin-4 and listeriosis.: Immunol Rev. 1997 Aug;158:95-105. Unique Identifier : AIDSLINE MED/97459306; Kaufmann SH; Emoto M; Szalay G; Barsig J; Flesch IE; Department of Immunology, University of Ulm, Germany.; Stefan.Kaufmann@Medizin.Uni-Uhn.De; Experimental infection of mice with Listeria monocytogenes (L. monocytogenes) has served as an appropriate model for analyzing Th1-cell-driven immune responses. Generally, Th2 responses are absent and IL-4 is not detectable. Here, we describe experimental settings under which IL-4 is detectable in listeriosis. Our dat
Cytokine production in saquinavir treated mice.: Int J Immunopharmacol. 1997 Apr;19(4):243-8. Unique Identifier : AIDSLINE MED/98041109; Pacifici R; Di Carlo S; Bacosi A; Pichini S; Zuccaro P; Clinical Biochemistry Department, Istituto Superiore di Sanita, Roma,; Italy.; The effects of chronic and acute saquinavir treatment on murine cytokine production were investigated in both plasma and splenocyte cultures. Cytokine plasma levels were below the detection limit in both saquinavir treated mice and in control mice with the exception of IFN-gamma, whose levels were detectable in 15 day
Presumed multifocal cryptococcol choroidopathy prior to specific systemic manifestation.: Int Ophthalmol. 1997;21(2):75-8. Unique Identifier : AIDSLINE MED/98069062; Rostomian K; Dugel PU; Kolahdouz-Isfahani A; Thach AB; Smith RE; Rao NA; Department of Ophthalmology, Doheny Eye Institute, University of; Southern California School of Medicine, Los Angeles, USA.; PURPOSE: Disseminated cryptococcosis is a major cause of morbidity and mortality in immunocompromised individuals, especially those with the acquired immunodeficiency syndrome AIDS). Early diagnosis and treatment greatly improves the outcome, so clinical clues that lead to prompt diagnosis are important. METHODS: Thre
Reduction of disease causative T-cells in experimental autoimmune disease models by a new antirheumatic drug, TAK-603.: Immunopharmacology. 1997 Oct;37(2-3):167-74. Unique Identifier : AIDSLINE MED/98067039; Ohta Y; Fukuda S; Makino H; Pharmaceutical Research Laboratories, Takeda Chemical Industries,; Ltd., Osaka, Japan.; We investigated the mode of action of a new quinoline derivative, TAK-603 (ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmeth yl) quinoline-3-carboxylate), in adjuvant arthritis (AA), a model of rheumatoid arthritis. AA rat splenocytes transferred the arthritis to normal syngeneic rats upon inoculat
A dimeric form of soluble recombinant sheep LFA-3(CD58) inhibits human T-cell proliferation by generating regulatory T cells.: Immunopharmacology. 1997 Oct;37(2-3):209-20. Unique Identifier : AIDSLINE MED/98067044; Yamashita K; Kakutani T; Ohashi T; Saibara T; Kaneka Corporation, Takasago Research Laboratories, Research; Institute, Hyogo, Japan.; We recently observed that the soluble recombinant from of sheep LFA-3, termed sLFA-3 is biologically active as determined by E-rosette inhibition and inhibition of human T-cell proliferation in response to the recall antigen. In the present study, we examined the immunosuppressive properties of a derivative of sLFA-3,
Current issues in the treatment and prophylaxis of Pneumocystis carinii pneumonia in HIV infection.: J Antimicrob Chemother. 1997 Sep;40(3):315-8. Unique Identifier : AIDSLINE MED/97478186; Morris-Jones SD; Easterbrook PJ; Department of HIV and Genitourinary Medicine, Chelsea & Westminster; Hospital, London, UK.
The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains.: J Biol Chem. 1998 Jan 2;273(1):386-91. Unique Identifier : AIDSLINE MED/98079073; Horuk R; Hesselgesser J; Zhou Y; Faulds D; Halks-Miller M; Harvey S; Taub D; Samson M; Parmentier M; Rucker J; Doranz BJ; Doms RW; Departments of Immunology, Pharmacology, and Cell Biology, Berlex; Biosciences, Richmond, California 94804, USA. Horuk@crl.com; Using a chemokine receptor model based on known receptor sequences, we identified several members of the seven transmembrane domain G-protein superfamily as potential chemokine receptors. The orphan receptor ChemR1, which has recently been shown to be a receptor for the CC chemokine I-309, scored very high in our mode
Conformational changes in cell surface HIV-1 envelope glycoproteins are triggered by cooperation between cell surface CD4 and co-receptors.: J Biol Chem. 1998 Jan 2;273(1):404-9. Unique Identifier : AIDSLINE MED/98079076; Jones PL; Korte T; Blumenthal R; Section of Membrane Structure and Function, Laboratory of Experimental; and Computational Biology, Division of Basic Sciences, National Cancer; Institute, National Institutes of Health, Frederick, Maryland 21702,; USA.; We have continuously measured CD4-induced conformational changes of cell surface-expressed human immunodeficiency virus type-1 envelope glycoprotein gp120-gp41 in situ using 4,4 -dianilino-1, 1 -binaphthyl-5,5 -disulfonic acid, a fluorescent probe that binds to hydrophobic groups. CD4-expressing human T cell lines ind
Quantification of cytomegalovirus DNA in peripheral blood leukocytes by a branched-DNA signal amplification assay.: J Clin Microbiol. 1997 Nov;35(11):2740-4. Unique Identifier : AIDSLINE MED/98010207; Chernoff DN; Miner RC; Hoo BS; Shen LP; Kelso RJ; Jekic-McMullen D; Lalezari JP; Chou S; Drew WL; Kolberg JA; Chiron Diagnostics, Emeryville, California 94608-2916, USA.; david_chernoff@cc.chiron.com; Quantification of cytomegalovirus ( CMV ) DNA in blood may aid in the identification of patients at highest risk for developing CMV disease, the evaluation of new therapeutics, and the prompt recognition of drug-resistant CMV s
Sequences of Pneumocystis carinii f. sp. hominis strains associated with recurrent pneumonia vary at multiple loci.: J Clin Microbiol. 1997 Nov;35(11):2745-7. Unique Identifier : AIDSLINE MED/98010208; Keely SP; Stringer JR; Department of Molecular Genetics, Biochemistry and Microbiology,; University of Cincinnati College of Medicine, Ohio 45267-0524, USA.; The sequences of the internal transcribed spacer (ITS) of Pneumocystis carinii f. sp. hominis strains from 7 of 15 AIDS patients were found to vary during discrete episodes of P. carinii pneumonia. Changes in the ITS sequence correlated with changes in the mitochondrial large-subunit rRNA sequence. The coincidence of
Rapid detection of Pneumocystis carinii in bronchoalveolar lavage specimens from human immunodeficiency virus-infected patients: use of a simple DNA extraction procedure and nested PCR.: J Clin Microbiol. 1997 Nov;35(11):2748-51. Unique Identifier : AIDSLINE MED/98010209; Rabodonirina M; Raffenot D; Cotte L; Boibieux A; Mayencon M; Bayle G; Persat F; Rabatel F; Trepo C; Peyramond D; Piens MA; Departement de Parasitologie et de Mycologie, Universite; Claude-Bernard, Lyon, France. liou@cismsun.univ-lyon1.fr; We report on the development of a rapid nested PCR protocol for the detection of Pneumocystis carinii DNA in bronchoalveolar lavage (BAL) specimens in which the protocol included the use of a commercially available DNA extraction kit (GeneReleaser). GeneReleaser enabled us to obtain amplification-ready DNA within 20 m
Inhibitory effects of polyoxyethylene stearate, PANTA, and neutral pH on growth of Mycobacterium genavense in BACTEC primary cultures.: J Clin Microbiol. 1997 Nov;35(11):2791-4. Unique Identifier : AIDSLINE MED/98010218; Realini L; Van Der Stuyft P; De Ridder K; Hirschel B; Portaels F; Division of Infectious Diseases, Hopital Cantonal, Geneva,; Switzerland. realini@itg.be; We report on the influences of polyoxyethylene stearate (POES), PANTA, and pH on primary cultures of Mycobacterium genavense in BACTEC vials. As a model for primary cultures from tissue, seven different strains first isolated from AIDS patients (five from Switzerland and two f
Quantification of human immunodeficiency virus type 1 RNA from dried plasma spots collected on filter paper.: J Clin Microbiol. 1997 Nov;35(11):2795-801. Unique Identifier : AIDSLINE MED/98010219; Cassol S; Gill MJ; Pilon R; Cormier M; Voigt RF; Willoughby B; Forbes J; Ottawa General Hospital Research Institute and the University of; Ottawa, Ontario, Canada.; To assess dried plasma spots (DPSs) as a source of material for virus quantification, human immunodeficiency virus type 1 (HIV-1) RNA levels were quantified in matched DPS and liquid plasma samples from 73 infected patients, including 5 neonates and 4 adult patients with acute HIV-1 infection. Quantifications were per
Detection of rifampin resistance by single-strand conformation polymorphism analysis of cerebrospinal fluid of patients with tuberculosis of the central nervous system.: J Clin Microbiol. 1997 Nov;35(11):2802-6. Unique Identifier : AIDSLINE MED/98010220; Scarpellini P; Braglia S; Brambilla AM; Dalessandro M; Cichero P; Gori A; Lazzarin A; Infectious Diseases Division, San Raffaele Scientific Institute,; Milan, Italy. scarpep@hsr.it; Mutations in a 69-bp region of the rpoB gene of Mycobacterium tuberculosis are associated with rifampin resistance (Rif[r]). These have been detected with mycobacterial DNA extracted from bacterial suspensions or respiratory specimens that were acid-fast smear positive. We experimented with a strategy for the rapid de
Performance of the Amplicor human immunodeficiency virus type 1 PCR and analysis of specimens with false-negative results.: J Clin Microbiol. 1997 Nov;35(11):2846-53. Unique Identifier : AIDSLINE MED/98010228; Barlow KL; Tosswill JH; Parry JV; Clewley JP; Virus Reference Division, Central Public Health Laboratory, London,; United Kingdom.; Over a 4-year period, the Roche Amplicor kit was used in a United Kingdom reference laboratory for the detection or confirmation of human immunodeficiency virus (HIV) type 1 infection, particularly in infants born to HIV-infected mothers. Of 408 specimens from adults and older children
Comparison of a photometric method with standardized methods of antifungal susceptibility testing of yeasts.: J Clin Microbiol. 1997 Nov;35(11):2878-82. Unique Identifier : AIDSLINE MED/98010234; Clancy CJ; Nguyen MH; Department of Medicine, College of Medicine, University of Florida,; and the Veterans Affairs Medical Center, Gainesville 32610, USA.; We determined the fluconazole MICs for 101 clinical isolates of Candida and Cryptococcus neoformans using the macro- and microdilution methods recommended by the National Committee for Clinical Laboratory Standards. We compared the MICs obtained by these methods with those obtained by a photometric assay that quantifi
Seroprevalence of Bartonella henselae infection and correlation with disease status in cats in Switzerland.: J Clin Microbiol. 1997 Nov;35(11):2883-5. Unique Identifier : AIDSLINE MED/98010235; Glaus T; Hofmann-Lehmann R; Greene C; Glaus B; Wolfensberger C; Lutz H; Department of Veterinary Internal Medicine, University of Zurich,; Switzerland.; The prevalence of infection with Bartonella henselae was investigated in cats from different areas of Switzerland . Serum samples of 728 cats were examined for antibodies to B. henselae by immunofluorescent antibody testing, and the results were analyzed with a view to a possib
Effects of specimen collection, processing, and storage conditions on stability of human immunodeficiency virus type 1 RNA levels in plasma.: J Clin Microbiol. 1997 Nov;35(11):2886-93. Unique Identifier : AIDSLINE MED/98010236; Ginocchio CC; Wang XP; Kaplan MH; Mulligan G; Witt D; Romano JW; Cronin M; Carroll R; Department of Medicine, North Shore University Hospital, Manhasset,; New York 11030, USA. cginocch@nshs.edu; To define the optimal blood collection parameters for plasma human immunodeficiency virus type 1 (HIV-1) viral load testing, plasma HIV-1 RNA levels were quantitated with the NASBA HIV-1 RNA QT System from blood specimens that were collected, processed, and stored under a variety of conditions that might have affected
Scytalidium dimidiatum and Lecythophora hoffmannii: unusual causes of fungal infections in a patient with AIDS.: J Clin Microbiol. 1997 Nov;35(11):2949-52. Unique Identifier : AIDSLINE MED/98010248; Marriott DJ; Wong KH; Aznar E; Harkness JL; Cooper DA; Muir D; Department of Medical Microbiology and Infectious Diseases, St.; Vincent's Hospital, Sydney, Australia.; Immunocompromised patients are susceptible to infections by fungi that seldom cause disease in humans. We describe a human immunodeficiency virus-infected patient who had simultaneous infections with two fungi which are rare causes of serious infection: Lecythophora hoffmannii, causing chronic sinusitis, and Scytalidi
Characterization to species level of Mycobacterium avium complex strains from human immunodeficiency virus-positive and -negative patients.: J Clin Microbiol. 1997 Nov;35(11):3001-3. Unique Identifier : AIDSLINE MED/98010263; Kyriakopoulos AM; Tassios PT; Matsiota-Bernard P; Marinis E; Tsaousidou S; Legakis NJ; Department of Microbiology, Medical School, University of Athens,; Greece.; Forty human clinical Mycobacterium avium-M. intracellulare complex strains isolated in Greece were characterized to the species level by PCR with three sets of primers specific for one or both species. M. avium predominated in both
Absence of human herpesvirus 8 DNA in benign and malignant endothelial lesions [letter]: J Clin Microbiol. 1997 Nov;35(11):3010. Unique Identifier : AIDSLINE MED/98010267; Viviano E; Romano N; Sorce M; Castelli E; Marasa L
Typing of Pneumocystis carinii f. sp. hominis by single-strand conformation polymorphism of four genomic regions.: J Clin Microbiol. 1997 Dec;35(12):3086-91. Unique Identifier : AIDSLINE MED/98060420; Hauser PM; Francioli P; Bille J; Telenti A; Blanc DS; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; Philippe.Hauser@chuv.hospvd.ch; To better investigate Pneumocystis carinii f. sp. hominis epidemiology, we have developed a molecular typing method. Because of the limited genetic variability of the P. carinii hominis genome, a multitarget approach was used. Four variable regions of the genome were amplified by PCR, polymorphism in each region was a
Comparison of the Amplicor HIV-1 monitor test and the nucleic acid sequence-based amplification assay for quantitation of human immunodeficiency virus RNA in plasma, serum, and plasma subjected to freeze-thaw cycles.: J Clin Microbiol. 1997 Dec;35(12):3288-91. Unique Identifier : AIDSLINE MED/98060457; Griffith BP; Rigsby MO; Garner RB; Gordon MM; Chacko TM; National Virology Reference Laboratory, VA Connecticut Health Care; System, West Haven Campus, 06516, USA.; The Amplicor HIV-1 Monitor test was compared to the nucleic acid sequence-based amplification (Nasba) assay system for the quantitation of human immunodeficiency virus (HIV) RNA in three different types of clinical samples: plasma, serum, and plasma subjected to freeze-and-thaw cycles. Each assay detected HIV RNA in t
HIV-1 protease inhibitors and the MDR1 multidrug transporter [editorial]: J Clin Invest. 1998 Jan 15;101(2):287-8. Unique Identifier : AIDSLINE MED/98099765; Lee CG; Gottesman MM
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.: J Clin Invest. 1998 Jan 15;101(2):289-94. Unique Identifier : AIDSLINE MED/98099766; Kim RB; Fromm MF; Wandel C; Leake B; Wood AJ; Roden DM; Wilkinson GR; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt; University School of Medicine, Nashville, Tennessee 37232-6602, USA.; Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral absorption and variable tissue distribution, both of which are largely unexplained, complicate their use. We tested the hypothesis that P-glycopr
Isolation of mycobacterium-reactive CD1-restricted T cells from patients with human immunodeficiency virus infection.: J Clin Invest. 1998 Jan 15;101(2):383-9. Unique Identifier : AIDSLINE MED/98099777; Gong J; Stenger S; Zack JA; Jones BE; Bristol GC; Modlin RL; Morrissey PJ; Barnes PF; Center for Pulmonary and Infectious Disease Control, The University of; Texas Health Center, Tyler, Texas 75710, USA.; Because CD1-restricted T cells lack CD4 but produce IFN-gamma in response to nonpeptide mycobacterial antigens, they could play a unique role in immunity to tuberculosis. We studied CD1-restricted T cells in the context of HIV infection by expanding CD4(-) T cell lines from 10 HIV-infected patients. Upon stimulation w
Plasma cytomegalovirus (CMV) DNA load predicts CMV disease and survival in AIDS patients.: J Clin Invest. 1998 Jan 15;101(2):497-502. Unique Identifier : AIDSLINE MED/98099790; Spector SA; Wong R; Hsia K; Pilcher M; Stempien MJ; University of California at San Diego, La Jolla, California 92093,; USA. saspector@ucsd.edu; In this study, baseline plasma from 619 persons with acquired immunodeficiency syndrome (AIDS) (median CD4+ lymphocyte count 21/microl) who participated in a trial to determine the efficacy of oral ganciclovir for cytomegalovirus (
The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells.: J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):792-801. Unique Identifier : AIDSLINE MED/98099326; Punnonen J; Yssel H; de Vries JE; Human Immunology Department, DNAX Research Institute of Molecular and; Cellular Biology, Inc., Palo Alto, CA 94304-1104, USA.; The relative contribution of IL-4 and IL-13 to the regulation of IgE synthesis has remained relatively poorly characterized, partially because of lack of suitable animal models. We have studied the roles of IL-4 and IL-13 in human IgE synthesis induced by supernatants derived from activated CD4+ or CD8+ T cell clones.
Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation.: J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):838-45. Unique Identifier : AIDSLINE MED/98099332; Munoz-Fernandez MA; Navarro J; Garcia A; Punzon C; Fernandez-Cruz E; Fresno M; Division of Immunology, Hospital Universitario Gregorio Maranon,; Madrid, Spain.; Tumor necrosis factor (TNF)-alpha controls T-cell activation and is a major inducer of human immunodeficiency virus (HIV)-1 replication in chronically infected cells. Therefore, we have investigated its role in primary cultures of HIV-infected human T lymphocytes by using neutralizing anti-TNF-alpha antibodies or TNF-
Simple diagnosis of graft-versus-host disease.: J Allergy Clin Immunol. 1997 Dec;100(6 Pt 2):S70-2. Unique Identifier : AIDSLINE MED/98101498; Hiraoka A; Kawakami M; Fukuda H; Nakamura H; Karasuno T; Teshima H; Masaoka T; Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.; BACKGROUND: Among patients undergoing allogeneic bone marrow transplantation, we previously detected an increase of CD8+S6F1+ and CD8+CD57- cells with the onset of acute graft-versus-host disease. OBJECTIVE: This study was an attempt to develop a simple laboratory test for graft-versus-host disease. METHODS: We analyz
Human granulocyte-macrophage colony-stimulating factor hGM-CSF)-dependent in vitro and in vivo proliferation and differentiation of all hematopoietic progenitor cells in hGM-CSF receptor transgenic mice.: J Allergy Clin Immunol. 1997 Dec;100(6 Pt 2):S79-86. Unique Identifier : AIDSLINE MED/98101501; Nishijima I; Watanabe S; Nakahata T; Arai K; The Department of Molecular and Developmental Biology, Institute of; Medical Science, The University of Tokyo, Japan.; To examine the relation between receptor expression and differentiation of hematopoietic cells, we produced transgenic mice that constitutively expressed the human granulocyte-macrophage colony stimulating factor (hGM-CSF) receptor at almost all stages of hematopoietic cell development. The high-affinity GM-CSF recept
Engrafted maternal T cells in human severe combined immunodeficiency: evidence for a TH2 phenotype and a potential role of apoptosis on the restriction of T-cell receptor variable beta repertoire.: J Allergy Clin Immunol. 1998 Jan;101(1 Pt 1):131-4. Unique Identifier : AIDSLINE MED/98109569; Plebani A; Stringa M; Priglione I; Facchetti P; Ghiotto F; Airoldi I; Giacchino R; Cristina E; Porta F; Grossi CE; Pistoia V; Department of Pediatrics, Scientific Institute G. Gaslini, Genova,; Italy.
[Measles and pregnancy. Apropos of 16 cases in Burkina Faso]: J Gynecol Obstet Biol Reprod (Paris). 1997;26(6):606-9. Unique Identifier : AIDSLINE MED/98064249; Dao B; Koalaga AP; Ki Zerbo G; Bambara M; Bazie AJ; Service de Gynecologie-Obstetrique, Centre Hospitalier National Souro; Sanou, Bobo Dioulasso, Burkina Faso.; We report an epidemic of 16 cases of measles during pregnancy. The risk factors for such an association and the materno-fetal outcomes are presented. The mean age of the patients was 20.6 years, with a mean gravidity and parity of 2.1 and 1.1 respectively. The mean clinical features were: conjunctivitis, hyperthermia
Detection of serum antibodies against phosphocholine-containing aminoglycoglycerolipid specific to Mycoplasma fermentans in HIV-1 infected individuals.: J Immunol Methods. 1997 Oct 13;208(1):103-13. Unique Identifier : AIDSLINE MED/98095051; Li JL; Matsuda K; Takagi M; Yamamoto N; Department of Microbiology, Tokyo Medical and Dental University,; Japan.; Mycoplasma fermentans has been associated with acquired immunodeficiency syndrome (AIDS). The lipids extracted from five strains of M. fermentans and eight other species of mycoplasmas were investigated. By using high-performance thin-layer chromatography (HPTLC) and immunostaining on HPTLC-plates with polyclonal and
Single point dilution method for the quantitative analysis of antibodies to the gag24 protein of HIV-1.: J Immunol Methods. 1997 Oct 13;208(1):43-8. Unique Identifier : AIDSLINE MED/98095044; Palenzuela DO; Benitez J; Rivero J; Serrano R; Ganzo O; Division de Immunotecnologia y Diagnostico, Centro de Ingenieria; Genetica y Biotecnologia, La Habana, Cuba. lab.diagnostico@cigb.edu.cu; In the present work a concept proposed in 1992 by Dopotka and Giesendorf was applied to the quantitative analysis of antibodies to the p24 protein of HIV-1 in infected asymptomatic individuals and AIDS patients. Two approaches were analyzed, a linear model OD = b0 + b1.log(titer) and a nonlinear log(titer) = alpha.OD
Limiting dilution analysis of primary cytotoxic T-cell precursors.: J Immunol Methods. 1997 Oct 13;208(1):85-90. Unique Identifier : AIDSLINE MED/98095049; Zauderer M; Singer A; Cancer Center, University of Rochester Medical Center, NY 14642, USA.; mzauderer@cc.urmc.rochester.edu; An efficient colorimetric assay has been adapted for limiting dilution analysis of cytotoxic T-cell precursors. Application of this assay in a suitable experimental model of thymic education could be especially useful in identifying factors that shape the CD8 T-cell repertoire. The essential elements of such a model a
Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity.: J Exp Med. 1998 Jan 19;187(2):271-5. Unique Identifier : AIDSLINE MED/98095708; Schulz O; Sewell HF; Shakib F; Division of Molecular and Clinical Immunology, Faculty of Medicine and; Health Sciences, University of Nottingham, United Kingdom.; Recent reports have indicated that the cysteine protease activity of Der p 1 may play a significant role in its ability to elicit IgE antibody responses, mainly through cleavage of membrane CD23 on B cells and interleukin (IL)-4 synthesis and secretion from mast cells and basophils. Here we demonstrate for the first t
Frequencies of GB virus C/hepatitis G virus genomes and of specific antibodies in German risk and non-risk populations.: J Med Virol. 1997 Nov;53(3):218-24. Unique Identifier : AIDSLINE MED/98032589; Nubling CM; Bialleck H; Fursch AJ; Scharrer I; Schramm W; Seifried E; Schmidt U; Staszewski S; Lower J; Paul-Ehrlich-Institut, Langen, Germany. Nuebling@em.uni-frankfurt.de; The prevalence of the new flavivirus GB virus C/hepatitis virus G GBV-C/HGV) in different German populations was investigated by detection of viral genomes and anti-E2 antibodies. While blood donors had an overall prevalence of 10.4% there were increased rates for hemophiliacs (54.7%), hemodialysis patients (30.2%), m
Detection of hepatitis C virus genomic sequences in the cerebrospinal fluid of HIV-infected patients.: J Med Virol. 1997 Nov;53(3):252-4. Unique Identifier : AIDSLINE MED/98032595; Morsica G; Bernardi MT; Novati R; Uberti Foppa C; Castagna A; Lazzarin A; Infectious Diseases Department, San Raffaele Scientific Institute,; Milan, Italy.; To assess the presence of hepatitis C virus (HCV) in the central nervous system (CNS), HCV-RNA was sought in paired serum and cerebrospinal fluid (CSF) samples of 21 HIV/HCV-positive patients: HCV-RNA was detected in the serum of 19/21 patients 90.4%), and in the CSF of five of the 19 serum-positive patients. The pres
HIV-1 dynamics after transient antiretroviral therapy: implications for pathogenesis and clinical management.: J Med Virol. 1997 Nov;53(3):261-5. Unique Identifier : AIDSLINE MED/98032597; Phillips AN; McLean A; Johnson MA; Tyrer M; Emery V; Griffiths P; Bofill M; Janossy G; Loveday C; Department of Primary Care and Population Sciences, Royal Free; Hospital of Medicine, London, UK.; Simple models of CD4 lymphocyte interactions with human immunodeficiency virus (HIV) lead to the hypothesis that progression of HIV infection involves an increase in viral replicative capacity, due either to changes in the virus or in the host environment, or both. In order to consider how changes in plasma virus load
Detection rate and intratumoral virus load of human herpesvirus-8 in immunodeficiency-related B-cell lymphoid malignancies.: J Med Virol. 1997 Nov;53(3):277-81. Unique Identifier : AIDSLINE MED/98032600; Feuillard J; Aubin JT; Poirel L; Davi F; Kujas M; Rousselet MC; Angonin R; Raphael M; Agut H; Service d'Hematologie Biologique, Centre Hospitalier Avicenne,; Bobigny, France.; Human herpesvirus-8 (HHV-8), associated with Kaposi s sarcoma, primary effusion lymphoma, and Castleman s disease, has been found in circulating B-cells and might have a causative role in B-cell malignancies associated with immunodeficiency syndromes. We determined the rate of detection and intratumoral virus load of
Serum HBeAg quantitation during antiviral therapy for chronic hepatitis B.: J Med Virol. 1997 Nov;53(3):282-7. Unique Identifier : AIDSLINE MED/98032601; Heijtink RA; Kruining J; Honkoop P; Kuhns MC; Hop WC; Osterhaus AD; Schalm SW; Department of Virology, Erasmus University, Rotterdam, The; Netherlands.; Hepatitis Be antigen (HBeAg) seroconversion is considered the principal short-term goal of antiviral therapy in chronic hepatitis B. To test whether the pre- and per-treatment HBeAg quantitation has a higher predictive value than that of hepatitis B virus DNA (HBV-DNA) quantitation for the outcome of antiviral therapy
Saniculoside N from Sanicula europaea L.: J Nat Prod. 1997 Nov;60(11):1170-3. Unique Identifier : AIDSLINE MED/98054594; Arda N; Goren N; Kuru A; Pengsuparp T; Pezzuto JM; Qiu SX; Cordell GA; Department of Biology, Faculty of Science, University of Istanbul,; Turkey.; Extracts from the aerial parts of Sanicula europaea L. were investigated for their anti-HIV activity, and the 50% ethanolic extract was shown to exhibit the highest activity. A new triterpene saponin glycoside, 21 beta-(angeloyloxy)-3-O-[beta-D-arabinopyranosyl(1-->4)-beta- D-glucopyranosyl (1-->3)-beta-D-glucuronopyr
Epidemiology of onychomycosis in special-risk populations.: J Am Podiatr Med Assoc. 1997 Dec;87(12):546-50. Unique Identifier : AIDSLINE MED/98086994; Levy LA; California College of Podiatric Medicine, San Francisco 94115-4000,; USA.; A person s susceptibility to onychomycosis and the course of the disease once the nails are infected are functions of the interaction of the fungal agent, the host, and environmental factors. The disease is reported to have an overall prevalence of 2% to 13%, but the prevalence is much higher in certain populations, s
What the licensed practical/vocational nurse should know about pharmacological therapy for AIDS sufferers.: J Pract Nurs. 1997 Dec;47(4):48-57; quiz 58-60. Unique Identifier : AIDSLINE MED/98106604; Edwards J Sr; Cook E; Shearer R; Davidhizer R; Bethel College, Mishawaka, IN, USA.; Illnesses can rob persons of their dignity and pride. Nowhere has this been more apparent than with people who suffer from Acquired Immunodeficiency Syndrome (AIDS). Because AIDS is a progressive and debilitating disease whose fatal outcome seems hopeless, it is often hard for the sufferer to maintain a sense of human
Gene transfer to human rheumatoid synovial tissue engrafted in SCID mice [see comments]: J Rheumatol. 1997 Nov;24(11):2076-9. Unique Identifier : AIDSLINE MED/98041711; Jorgensen C; Demoly P; Noel D; Mathieu M; Piechaczyc M; Gougat C; Bousquet J; Sany J; Service d'Immuno-Rhumatologie, Hopital Lapeyronie, Unite INSERM U291,; Montpellier, France.; OBJECTIVE: To assess the feasibility of gene therapy in rheumatoid arthritis (RA) and determine the appropriate vector. METHODS: Human rheumatoid synovial tissue from 6 patients with RA was transduced ex vivo with a recombinant retroviral vector pMFG.nlsLacZ) containing the Escherichia coli beta-galactosidase beta-gal
Digital necrosis in acquired immune deficiency syndrome vasculopathy treated with recombinant tissue plasminogen activator.: J Rheumatol. 1997 Nov;24(11):2258-61. Unique Identifier : AIDSLINE MED/98041743; Roh SS; Gertner E; University of Minnesota Medical School, St. Paul-Ramsey Medical; Center, 55101-2595, USA.; Widespread digital ischemic changes and gangrene of the hands and feet is an uncommon but dramatic presentation in patients with human immunodeficiency virus (HIV) infection. We describe a patient in whom these clinical findings were associated with elevated serum endothelin levels. Because endothelin may affect the f
Raynaud's phenomenon and digital gangrene as a consequence of treatment for Kaposi's sarcoma.: J Rheumatol. 1997 Dec;24(12):2371-5. Unique Identifier : AIDSLINE MED/98076126; Hladunewich M; Sawka C; Fam A; Franssen E; Division of Medical Oncology/Hematology, Toronto-Sunnybrook Regional; Cancer Centre, Toronto, Canada.; OBJECTIVE. To analyze the clinical features and to identify factors associated with the development of Raynaud s phenomenon RP) in patients receiving chemotherapy for human immunodeficiency virus (HIV) related Kaposi s sarcoma. METHODS. A retrospective cohort study of all patients with Kaposi s sarcoma treated with ch
Coexisting SLE and HIV infection [letter]: J Rheumatol. 1997 Dec;24(12):2490. Unique Identifier : AIDSLINE MED/98076152; Hirohata S
Prevalence and characteristics of rheumatic manifestations in patients infected with human immunodeficiency virus undergoing antiretroviral therapy [letter]: J Rheumatol. 1997 Dec;24(12):2492. Unique Identifier : AIDSLINE MED/98076155; Berman A; Cahn P; Perez H; Spindler A; Lucero E; Paz S; Espinoza LR
Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.: J Mol Biol. 1997 Dec 19;274(5):693-707. Unique Identifier : AIDSLINE MED/98070609; Henderson BR; Percipalle P; MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH,; England.; The human immunodeficiency virus type 1 (HIV-1) Rev protein binds to unspliced HIV-1 pre-mRNA and exports it from the nucleus. Rev itself can shuttle between the nucleus and cytoplasm. This bi-directional transport is mediated by two specific Rev sequences: a nuclear localisation signal (NLS), which overlaps the RNA
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.: J Mol Biol. 1997 Dec 19;274(5):738-47. Unique Identifier : AIDSLINE MED/98070612; Maga G; Amacker M; Ruel N; Hubscher U; Spadari S; Institute of Biochemical and Evolutionary Genetics I.G.B.E.-C.N.R.,; Pavia, I-27100, Italy.; The kinetic parameters governing the inhibition by Nevirapine of the RNA-dependent DNA synthesis catalyzed by HIV-1 reverse transcriptase have been determined by steady-state kinetic analysis with the wild-type enzyme and with mutant reverse transcriptases containing the single amino acid substitutions L100I, K103N, V
Lymphocytosis-producing factor [letter]: J Natl Med Assoc. 1997 Nov;89(11):711. Unique Identifier : AIDSLINE MED/98043042; Jordan WC
Evolution of case management of patients with HIV infection in France, 1995-1996. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine (GECSA) [letter]: JAMA. 1998 Jan 28;279(4):276. Unique Identifier : AIDSLINE MED/98111170; Spira R; Leroy V; Lacoste D; Salamon R; Dabis F
CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. French Pediatric HIV Infection Study Group [see comments]: JAMA. 1998 Jan 28;279(4):277-80. Unique Identifier : AIDSLINE MED/98111171; Misrahi M; Teglas JP; N'Go N; Burgard M; Mayaux MJ; Rouzioux C; Delfraissy JF; Blanche S; Laboratory of Hormonology and Molecular Biology, the Institut National; de la Sante et de la Recherche Medicale, Unite 292, Paris, France.; CONTEXT: Studies suggest that adults with the CCR5delta32 deletion are less likely to become infected with the human immunodeficiency virus (HIV) and to develop HIV-related disease progression, but the effect of the mutation in children is not known. OBJECTIVE: To study the effect of the CCR5 chemokine receptor mutant
Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials [see comments]: JAMA. 1998 Jan 28;279(4):281-6. Unique Identifier : AIDSLINE MED/98111172; Ioannidis JP; HIV Research Branch, Division of AIDS, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda, Md; 20892, USA. ji24m@nih.gov; CONTEXT: Medical evidence may be biased over time if completion and publication of randomized efficacy trials are delayed when results are not statistically significant. OBJECTIVE: To evaluate whether the time to completion and the time to publication of randomized phase 2 and phase 3 trials are affected by the statis
Chemokine receptors and genetic variability: another leap in HIV research [editorial; comment]: JAMA. 1998 Jan 28;279(4):317-8. Unique Identifier : AIDSLINE MED/98111179; O'Brien TR; Goedert JJ
[Support system for diagnosing hematologic malignancies]: Rinsho Byori. 1997 Nov;45(11):1031-7. Unique Identifier : AIDSLINE MED/98058364; Sugahara K; Tsuruda K; Yamada Y; Kamihira S; Central Diagnostic Laboratory, Nagasaki University Hospital.; We established a Southern blot hybridization using a DIG-labeled probe to detect monoclonal integration of HTLV-1 proviral genome. DIG was labeled by the PCR method and this probe was as sensitive as the 32P-labeled probe and able to detect only 1.6% of ATL cells. The clinical diagnoses of 44 patients with monoclonal
[Molecular pathomechanism of HTLV-I infectious diseases]: Rinsho Byori. 1997 Nov;45(11):1048-56. Unique Identifier : AIDSLINE MED/98058366; Kitajima I; Department of Laboratory Medicine, Kagoshima University of School of; Medicine.; Human T-cell lymphotropic virus type I(HTLV-I) is a type C retrovirus, closely associated with adult T-cell leukemia. In the past few years, studies have revealed an association between the virus and disorders of organ systems including myelopathy, polymyositis, alveolitis, and Sjogren s syndrome. In addition, we have
[Serum levels of soluble tumor necrosis factor receptors as markers for disease progression of human immunodeficiency virus infection]: Rinsho Byori. 1997 Nov;45(11):1085-90. Unique Identifier : AIDSLINE MED/98058372; Hattori M; Tateyama M; Oishi T; Miyasaka S; Fukutake K; Department of Clinical Pathology, Tokyo Medical College.; We studied whether the serum levels of soluble tumor necrosis factor receptor(sTNFR) type I or II correlate with clinical progression of human immunodeficiency virus type 1(HIV-1) infection. Serum levels of sTNFR type I and II were measured by an enzyme-linked immunosorbent assay in sixty five patients with HIV-1 infe
Distribution of bovine immunodeficiency virus in the organs of experimentally infected cows.: Jpn J Vet Res. 1997 Nov;45(3):163-7. Unique Identifier : AIDSLINE MED/98094417; Tajima M; Sato N; Kirisawa R; Onuma M; Maede Y; Department of Veterinary Clinical Sciences, Graduate School of; Veterinary Medicine, Hokkaido University, Sapporo, Japan.; motoshi@vetmed.hokudai.ac.jp; The distribution of bovine immunodeficiency virus (BIV) in the organs of experimentally infected cows was investigated by use of nested polymerase chain reaction (PCR). Two cows (Nos. 1 and 2) experimentally infected with BIV were alive without any clinical symptoms of BIV infection for 28 months. Viral and proviral g
Paraproteinemia, plasmacytoma, myeloma and HIV infection.: Leukemia. 1997 Dec;11(12):2150-6. Unique Identifier : AIDSLINE MED/98107523; Fiorino AS; Atac B; Medical Scientist Training Program, Albert Einstein College of; Medicine, Bronx, NY, USA.; We have identified by MEDLINE search the cases of gammaglobinopathy and plasma cell malignancy in HIV-positive patients reported in the English language literature. The average age at presentation among HIV-positive patients with plasma cell disorders is 33 years, far younger than the average age of presentation in th
First case of plasma-cell leukaemia co-existing with human immunodeficiency virus infection [letter]: Leukemia. 1998 Jan;12(1):103-4. Unique Identifier : AIDSLINE MED/98097429; Heuberger L; Costello RT; Petit N; Fripiat F; Gastaut JA
Reconstitution of peripheral blood lymphocyte subsets in the long-term disease-free survivors of patients with acute myeloblastic leukemia.: Leukemia. 1998 Jan;12(1):52-8. Unique Identifier : AIDSLINE MED/98097420; Ohnishi K; Yamanishi H; Naito K; Utsumi M; Yokomaku S; Hirabayashi N; Ohno R; Department of Medicine III, Hamamatsu University School of Medicine,; Japan.; The number of long-term survivors of patients with acute myeloblastic leukemia (AML) has increased as a result of the progress of chemotherapy. We examined the recovery of peripheral blood lymphocytes (PBL) subset after chemotherapy to clarify the reconstitution of the immune system in AML. Thirty patients with AML in
Human immunodeficiency virus infection and pulmonary hypertension: two new cases and a review of 86 reported cases.: Mayo Clin Proc. 1998 Jan;73(1):37-45. Unique Identifier : AIDSLINE MED/98103913; Mesa RA; Edell ES; Dunn WF; Edwards WD; Department of Internal Medicine, Mayo Clinic Rochester, Minnesota; 55905, USA.; In this article, we describe pulmonary hypertension in two men 31 and 43 years of age) with human immunodeficiency virus (HIV) infection who were examined at Mayo Clinic Rochester. Among 88 reported cases (including the two current ones) of HIV- or acquired immunodeficiency syndrome (AIDS)-associated pulmonary hyperte
A year of transformation in HIV/AIDS.: Lancet. 1995 Dec 23-30;346 Suppl:s12. Unique Identifier : AIDSLINE MED/98119210; Montaner JS; Schechter MT; Faculty of Medicine, University of British Columbia, Vancover, BC,; Canada.
Respiratory medicine. Huffing and puffing.: Lancet. 1995 Dec 23-30;346 Suppl:s21. Unique Identifier : AIDSLINE MED/98119219; Warren P; Khalil N; Respiratory Hospital, Winnipeg, Manitoba, Canada.
Cost-effectiveness of improved treatment services for sexually transmitted diseases in preventing HIV-1 infection in Mwanza Region, Tanzania.: Lancet. 1997 Dec 20-27;350(9094):1805-9. Unique Identifier : AIDSLINE MED/98089852; Gilson L; Mkanje R; Grosskurth H; Mosha F; Picard J; Gavyole A; Todd J; Mayaud P; Swai R; Fransen L; Mabey D; Mills A; Hayes R; London School of Hygiene and Tropical Medicine, UK.; BACKGROUND: A community-randomised trial was undertaken to assess the impact, cost, and cost-effectiveness of averting HIV-1 infection through improved management of sexually transmitted diseases (STDs) by primary-health-care workers in Mwanza Region, Tanzania . METHODS: The impac
Indinavir in cerebrospinal fluid of HIV-1-infected patients [letter]: Lancet. 1997 Dec 20-27;350(9094):1823. Unique Identifier : AIDSLINE MED/98089862; St~ahle L; Martin C; Svensson JO; Sonnerborg A
Another HIV-1 trial loses placebo control [news]: Lancet. 1997 Dec 20-27;350(9094):1831. Unique Identifier : AIDSLINE MED/98089865; Kigotho AW
HIV/AIDS: protease inhibitors vindicated.: Lancet. 1997;350 Suppl 3:SIII10. Unique Identifier : AIDSLINE MED/98089923; Volberding PA; UCSF AIDS program, San Francisco General Hospital, CA 94110, USA.
Public health: leadership is a global issue.: Lancet. 1997;350 Suppl 3:SIII23. Unique Identifier : AIDSLINE MED/98089936; Mann JM; Francois-Xavier Bagnoud Center for Health and Human Rights, Harvard; School of Public Health, Boston, MA 02115, USA.
Sexually transmitted diseases: treating the whole syndrome.: Lancet. 1997;350 Suppl 3:SIII25. Unique Identifier : AIDSLINE MED/98089938; Laga M; Dallabetta G; STD/HIV Research and Intervention Unit, Institute of Tropical; Medicine, Antwerp, Belgium.
HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene [see comments]: Lancet. 1998 Jan 3;351(9095):14-8. Unique Identifier : AIDSLINE MED/98095008; Quillent C; Oberlin E; Braun J; Rousset D; Gonzalez-Canali G; Metais P; Montagnier L; Virelizier JL; Arenzana-Seisdedos F; Beretta A; Centre Integre de Recherches Biocliniques sur le SIDA, Hopital St; Joseph, Paris, France.; BACKGROUND: Despite multiple exposures to HIV-1, some individuals remain uninfected, and their peripheral-blood mononuclear cells PBMC) are resistant to in-vitro infection by primary HIV-1 isolates. Such resistance has been associated with a homozygous 32-base-pair deletion (delta 32) in the C-C chemokine receptor gen
Chemokine-receptor polymorphisms: clarity or confusion for HIV-1 prognosis? [comment]: Lancet. 1998 Jan 3;351(9095):2-3. Unique Identifier : AIDSLINE MED/98095001; Garred P; Department of Clinical Immunity, Rigshospitalet, Copenhagen, Denmark.
Model for sexual health found in India's West Bengal [news]: Lancet. 1998 Jan 3;351(9095):46. Unique Identifier : AIDSLINE MED/98119183; Kumar S
Antiretroviral therapy in sub-Saharan Africa [letter]: Lancet. 1998 Jan 3;351(9095):68. Unique Identifier : AIDSLINE MED/98095034; Muller O; Corrah T; Katabira E; Plummer F; Mabey D
Intestinal parasites in AIDS and +HIV patients in Uberlandia, Minas Gerais, Brazil.: Mem Inst Oswaldo Cruz. 1996 Nov-Dec;91(6):685-6. Unique Identifier : AIDSLINE MED/97429294; Costa-Cruz JM; Ferreira MS; Rossin IR; Departamento de Patologia, Centro de Ciencias Biomedicas, Universidade; Federal de Uberlandia, MG, Brasil.
HIV-1 isolation from plasma specimens. HEC/FIOCRUZ AIDS Clinical Research Group.: Mem Inst Oswaldo Cruz. 1996 Nov-Dec;91(6):745-6. Unique Identifier : AIDSLINE MED/97429307; Costa CI; Morgado MG; Santos VG; Bongertz V; Departamento de Imunologia, Hospital Evandro Chagas, Instituto Oswaldo; Cruz, Rio de Janeiro, Brasil.
The Rio de Janeiro HIV vaccine site-II. Recruitment strategies and socio-demographic data of a HIV negative homosexual and bisexual male cohort in Rio de Janeiro, Brazil.: Mem Inst Oswaldo Cruz. 1997 Jan-Feb;92(1):39-46. Unique Identifier : AIDSLINE MED/97447986; Sutmoller F; de Souza CT; Monteiro JC; Penna T; Hospital Evandro Chagas, Instituto Oswaldo Cruz, Rio de Janeiro,; Brasil.; The initial effort of the Brazilian Ministry of Health to be an active partner in the world effort in the preparation of future accurate human immune deficiency virus (HIV) efficacy trials was the establishment of a multi-centered cohort of homosexual and bisexual men. An open cohort was established to determine the H
[Detection and characteristics of sequences of human chromosome 19, having partial similarity with human immunodeficiency virus type 1 tat/rev regulatory genes]: Mol Biol (Mosk). 1997 Sep-Oct;31(5):814-9. Unique Identifier : AIDSLINE MED/98012316; Khaidarova NV; Alekseevskaia OD; Tarantul VZ
[Theoretical study of peptide spatial structure--fragments of the base antigenic determinant of HIV-1 gp120 protein. I. Peptides rp142 and rp342]: Mol Biol (Mosk). 1997 Sep-Oct;31(5):861-71. Unique Identifier : AIDSLINE MED/98012322; Andrianov AM
[Theoretical study of peptide spatial structure--fragments of the base antigenic determinant of HIV-1 gp120 protein. II. Hexapeptide Gly-Pro- Gly-Arg-Ala-Phe]: Mol Biol (Mosk). 1997 Sep-Oct;31(5):872-9. Uniq